Frances Ashcroft

Q: What Schools Are Affiliated With Frances Ashcroft

Frances Ashcroft is affiliated with the following schools: University of Cambridge, University of Leicester, University of Bristol, University of Oxford, University College London, Gifu University

Frances Ashcroft's AcademicInfluence.com Rankings

Frances Ashcroft

Biology

#1664

World Rank

#2723

Historical Rank

Physiology

#31

World Rank

#111

Historical Rank

Genetics

#252

World Rank

#302

Historical Rank

biology Degrees

Download Badge

Biology

Why Is Frances Ashcroft Influential?

(Suggest an Edit or Addition)

According to Wikipedia, Dame Frances Mary Ashcroft is a British ion channel physiologist. She is Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology at the University of Oxford. She is a fellow of Trinity College, Oxford, and is a director of the Oxford Centre for Gene Function. Her research group has an international reputation for work on insulin secretion, type II diabetes and neonatal diabetes. Her work with Andrew Hattersley has helped enable children born with diabetes to switch from insulin injections to tablet therapy.

(See a Problem?)

Frances Ashcroft's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

VIII. References (1955) (1393)
The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase (2007) (1375)
Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells (1984) (1095)
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. (2004) (1091)
Electrophysiology of the pancreatic beta-cell. (1989) (1078)
Adenosine 5'-triphosphate-sensitive potassium channels. (1988) (912)
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. (2006) (910)
Crystal Structure of the Potassium Channel KirBac1.1 in the Closed State (2003) (807)
Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor (1997) (786)
Diabetes Mellitus and the β Cell: The Last Ten Years (2012) (754)
Properties and functions of ATP-sensitive K-channels. (1990) (696)
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. (2007) (638)
Overexpression of Fto leads to increased food intake and results in obesity (2010) (632)
ATP-sensitive potassium channelopathies: focus on insulin secretion. (2005) (546)
ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis (2001) (526)
Sulfonylurea stimulation of insulin secretion. (2002) (444)
Correlating structure and function in ATP-sensitive K+ channels (1998) (424)
ATP-sensitive K+ channels and insulin secretion: their role in health and disease (1999) (416)
Cloning and functional expression of the cDNA encoding a novel ATP‐sensitive potassium channel subunit expressed in pancreatic β‐cells, brain, heart and skeletal muscle (1995) (408)
Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy. (2005) (401)
Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells (1993) (397)
PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism (2007) (393)
From molecule to malady (2006) (376)
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men. (2018) (367)
The essential role of the Walker A motifs of SUR1 in K‐ATP channel activation by Mg‐ADP and diazoxide (1997) (336)
A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene (2009) (318)
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. (2006) (307)
Exocytosis elicited by action potentials and voltage‐clamp calcium currents in individual mouse pancreatic B‐cells. (1993) (297)
Control of pancreatic β cell regeneration by glucose metabolism. (2011) (290)
The sulfonylurea receptor. (1992) (267)
Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels. (1998) (261)
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1. (2000) (252)
A Novel Method for Measurement of Submembrane ATP Concentration* (2000) (251)
Inwardly rectifying potassium channels. (1999) (246)
Molecular determinants of KATP channel inhibition by ATP (1998) (246)
The ATP‐sensitivity of K+ channels in rat pancreatic B‐cells is modulated by ADP (1986) (245)
Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features. (2004) (231)
Stimulus–secretion coupling in pancreatic β cells (1994) (229)
Overlapping distribution of KATP channel‐forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain (1997) (226)
KATP channels and islet hormone secretion: new insights and controversies (2013) (224)
Functional analysis of a structural model of the ATP‐binding site of the KATP channel Kir6.2 subunit (2005) (206)
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose (2014) (204)
Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects. (2007) (199)
A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes. (2006) (198)
Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel. (1999) (193)
New windows on the mechanism of action of K(ATP) channel openers. (2000) (189)
Relapsing diabetes can result from moderately activating mutations in KCNJ11. (2005) (186)
Properties of cloned ATP‐sensitive K+ currents expressed in Xenopus oocytes. (1997) (183)
A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1 (2003) (180)
Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes (2013) (180)
MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit. (1998) (180)
3‐D structural and functional characterization of the purified KATP channel complex Kir6.2–SUR1 (2005) (175)
Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP (1998) (174)
Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels (1996) (169)
FTO influences adipogenesis by regulating mitotic clonal expansion (2015) (168)
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells (2019) (167)
Simultaneous recordings of glucose dependent electrical activity and ATP‐regulated K+‐currents in isolated mouse pancreatic β‐cells (1990) (166)
Ion channels and disease (1999) (162)
The Interaction of nucleotides with the tolbutamide block of cloned atp‐sensitive k+ channel currents expressed in xenopus oocytes: a reinterpretation (1997) (160)
Phentolamine block of KATP channels is mediated by Kir6.2. (1997) (158)
Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells. (1993) (156)
Orexin Excites GABAergic Neurons of the Arcuate Nucleus by Activating the Sodium—Calcium Exchanger (2003) (153)
SYMPOSIUM REVIEW: The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet (2010) (152)
A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in Finland. (1999) (151)
Metabolic regulation of the pancreatic beta-cell ATP-sensitive K+ channel: a pas de deux. (2004) (151)
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion. (2014) (149)
Role for the obesity-related FTO gene in the cellular sensing of amino acids (2013) (149)
Mechanism of Cloned ATP-sensitive Potassium Channel Activation by Oleoyl-CoA* (1998) (147)
ATP‐sensitive K+ channels in rat pancreatic beta‐cells: modulation by ATP and Mg2+ ions. (1989) (145)
Perspectives in Diabetes Activating Mutations in Kir 6 . 2 and Neonatal Diabetes New Clinical Syndromes , New Scientific Insights , and New Therapy (2005) (143)
Mechanisms of the glycaemic effects of sulfonylureas. (1996) (141)
ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion. (1990) (140)
Deletion of Nicotinamide Nucleotide Transhydrogenase (2006) (140)
Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic β -cells (1989) (137)
SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator (2009) (136)
Electrogenic arginine transport mediates stimulus‐secretion coupling in mouse pancreatic beta‐cells. (1997) (135)
Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse (2013) (133)
Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules (2009) (124)
Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 2006;55:2153–2156 (2014) (118)
PIP2-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations† (2009) (118)
A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome (2005) (115)
Ion channels and disease : channelopathies (2000) (114)
Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. (2014) (114)
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. (2008) (114)
Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels. (2000) (113)
Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11 (2007) (112)
Differential sensitivity of beta-cell and extrapancreatic KATP channels to gliclazide (1999) (111)
The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady. (2007) (110)
A novel mutation causing DEND syndrome (2007) (109)
Type 2 diabetes mellitus: not quite exciting enough? (2004) (109)
Direct Photoaffinity Labeling of the Kir6.2 Subunit of the ATP-sensitive K+ Channel by 8-Azido-ATP* (1999) (107)
Q&A: insulin secretion and type 2 diabetes: why do β-cells fail? (2015) (103)
R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion (2007) (102)
Mutations within the P-Loop of Kir6.2 Modulate the Intraburst Kinetics of the Atp-Sensitive Potassium Channel (2001) (97)
Involvement of the N‐terminus of Kir6.2 in coupling to the sulphonylurea receptor (1999) (96)
Muscle Dysfunction Caused by a KATP Channel Mutation in Neonatal Diabetes Is Neuronal in Origin (2010) (95)
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion (2019) (94)
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. (2008) (94)
Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in white caucasian subjects or evidence of abnormal function when expressed in vitro (1996) (89)
Potassium channel regulation (2003) (88)
Identification of residues contributing to the ATP binding site of Kir6.2 (2003) (86)
Effect of repaglinide on cloned beta cell, cardiac and smooth muscle types of ATP-sensitive potassium channels (2001) (86)
Long-Term Exposure to Glucose and Lipids Inhibits Glucose-Induced Insulin Secretion Downstream of Granule Fusion With Plasma Membrane (2007) (85)
The antimalarial agent mefloquine inhibits ATP‐sensitive K‐channels (2000) (84)
Calcium dependence of the inactivation of calcium currents in skeletal muscle fibers of an insect. (1981) (83)
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells (2016) (83)
Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1. (2002) (82)
The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying K+ channel Kir6.1 expressed in human embryonic kidney cells. (1996) (82)
FTO Is Expressed in Neurones throughout the Brain and Its Expression Is Unaltered by Fasting (2011) (81)
K(ATP) channels and insulin secretion: a key role in health and disease. (2006) (79)
Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells (2001) (79)
Insulin : molecular biology to pathology (1992) (77)
Ca(2+)‐ and GTP‐dependent exocytosis in mouse pancreatic beta‐cells involves both common and distinct steps. (1996) (77)
Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues. (2000) (77)
Identification of the PIP2‐binding site on Kir6.2 by molecular modelling and functional analysis (2007) (76)
Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits. (1997) (76)
Involvement of the N‐terminus of Kir6.2 in the inhibition of the KATP channel by ATP (1999) (74)
Calcium and potassium currents in muscle fibres of an insect (Carausius morosus). (1982) (73)
How ATP Inhibits the Open KATP Channel (2008) (73)
Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. (1998) (71)
Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents (2015) (71)
Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression (2014) (71)
Electrical Inhibition of Identified Anorexigenic POMC Neurons by Orexin/Hypocretin (2007) (71)
Focus on Kir6.2: a key component of the ATP-sensitive potassium channel. (2005) (71)
Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP. (2005) (71)
Asymmetric Switching in a Homodimeric ABC Transporter: A Simulation Study (2010) (70)
Calcium inactivation in skeletal muscle fibres of the stick insect, Carausius morosus. (1982) (70)
Glucagon-Like Peptide 1 Stimulates Hypothalamic Proopiomelanocortin Neurons (2007) (70)
Identification and electrophysiology of isolated pars compacta neurons from guinea-pig substantia nigra (1991) (70)
Glimepiride block of cloned β‐cell, cardiac and smooth muscle KATP channels (2001) (69)
Neonatal Diabetes and the KATP Channel: From Mutation to Therapy (2017) (67)
Molecular Defects in Insulin Secretion in Type-2 Diabetes (2004) (67)
Modeling K(ATP) channel gating and its regulation. (2009) (67)
Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP‐sensitive potassium channel (2001) (66)
Metabolic inhibition and low internal ATP activate K-ATP channels in rat dopaminergic substantia nigra neurones (1995) (66)
Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress. (2006) (65)
Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2–SUR1 interactions (2005) (64)
Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells? (2017) (63)
Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes (2006) (62)
Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects (2006) (62)
Studies of the ATPase activity of the ABC protein SUR1 (2007) (62)
ATP Sensitivity of the ATP-Sensitive K+ Channel in Intact and Permeabilized Pancreatic β-Cells (2006) (62)
Cholecystokinin Tunes Firing of an Electrically Distinct Subset of Arcuate Nucleus Neurons by Activating A-Type Potassium Channels (2002) (61)
Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes (2016) (61)
Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants. (2003) (61)
Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels (2006) (60)
Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K+-channels in mouse pancreatic β-cells (1991) (59)
CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease (2009) (59)
Mapping of the Physical Interaction between the Intracellular Domains of an Inwardly Rectifying Potassium Channel, Kir6.2* (1999) (59)
The ligand‐sensitive gate of a potassium channel lies close to the selectivity filter (2003) (58)
ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer (2003) (58)
Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome. (2007) (56)
The dependence on intracellular ATP concentration of ATP‐sensitive K‐channels and of Na,K‐ATPase in intact HIT‐T15β‐cells (1989) (54)
Identification of four trp 1 gene variants murine pancreatic beta-cells (1997) (53)
New insights into KATP channel gene mutations and neonatal diabetes mellitus (2020) (53)
Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes (2017) (53)
Characterization and variation of a human inwardly‐rectifying K‐channel gene (KCNJ6): a putative ATP‐sensitive K‐channel subunit (1995) (53)
Malate transport and vacuolar ion channels in CAM plants. (1997) (52)
Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance (2008) (52)
Voltage‐activated calcium and potassium currents in human pancreatic beta‐cells. (1991) (52)
Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil. (2000) (52)
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production (2019) (52)
Single Ca channel currents in mouse pancreatic B-cells (1988) (51)
The role of lysine 185 in the Kir6.2 subunit of the ATP‐sensitive channel in channel inhibition by ATP (1999) (50)
Functional Analysis of a Mutant Sulfonylurea Receptor, SUR1-R1420C, That Is Responsible for Persistent Hyperinsulinemic Hypoglycemia of Infancy* (2000) (49)
A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic β-cells (1995) (49)
Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes (2007) (48)
Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia. (1995) (48)
A touching case of channel regulation: the ATP-sensitive K+ channel (1998) (48)
Cloning and functional expression of the cDNA encoding an inwardly‐rectifying potassium channel expressed in pancreatic β‐cells and in the brain (1995) (48)
Structural basis for the interference between nicorandil and sulfonylurea action. (2001) (47)
New uses for old drugs: neonatal diabetes and sulphonylureas. (2010) (46)
Potent and selective activation of the pancreatic beta-cell type KATP channel by two novel diazoxide analogues (2003) (46)
Molecular Mechanism of Sulphonylurea Block of KATP Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes (2013) (45)
Altered functional properties of KATP channel conferred by a novel splice variant of SUR1 (1999) (45)
Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes (2016) (45)
Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice (1998) (44)
Functional identification of islet cell types by electrophysiological fingerprinting (2017) (44)
ATP‐sensitive K+ channels in human isolated pancreatic B‐cells (1987) (43)
Mapping the architecture of the ATP‐binding site of the KATP channel subunit Kir6.2 (2004) (43)
Behavioral phenotyping of mice lacking the KATP channel subunit Kir6.2 (2006) (41)
Exciting Times for PIP2 (1998) (41)
Life at the extremes (2021) (41)
Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification (1998) (41)
Regulation of glucagon release from pancreatic A-cells. (1991) (41)
Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study. (2007) (40)
Identification of four trp1 gene variants murine pancreatic beta-cells. (1997) (40)
Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A. (2000) (40)
Functional Effects of Mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy (2006) (39)
Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding (2002) (39)
Dynamic Sensitivity of ATP-sensitive K+Channels to ATP* (2001) (39)
A Metabolic Sensor in Action: News From the ATP-Sensitive K+-Channel (1997) (38)
Rubidium and sodium permeability of the ATP‐sensitive K+ channel in single rat pancreatic beta‐cells. (1989) (38)
Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide. (2000) (38)
Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism (2009) (38)
Activation of the KATP channel by Mg-nucleotide interaction with SUR1 (2010) (37)
Inhibition of ATP-sensitive K+ channels by taurine through a benzamido-binding site on sulfonylurea receptor 1. (2004) (37)
Inward rectification in the transverse tubular system of frog skeletal muscle studied with potentiometric dyes. (1985) (37)
Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating. (2005) (37)
A mutation (R826W) in nucleotide‐binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes (2008) (36)
Introduction. The blurred boundary between channels and transporters (2009) (36)
Ion channels in viruses (2000) (36)
Miniglucagon (Glucagon 19–29), a Potent and Efficient Inhibitor of Secretagogue-induced Insulin Release through a Ca2+Pathway* (1999) (36)
Insulin secretion from beta-cells is affected by deletion of nicotinamide nucleotide transhydrogenase. (2009) (36)
A Kir6.2 Mutation Causing Neonatal Diabetes Impairs Electrical Activity and Insulin Secretion From INS-1 β-Cells (2006) (36)
Expression of functionally active ATP‐sensitive K‐channels in insect cells using baculovirus (1998) (35)
Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain. (2004) (35)
Expression of voltage‐gated K+ channels in insulin‐producing cells (1990) (34)
Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules (2011) (34)
Tamoxifen administration in pregnant mice can be deleterious to both mother and embryo (2019) (33)
Identification of a functionally important negatively charged residue within the second catalytic site of the SUR1 nucleotide-binding domains. (2004) (33)
ATP Modulation of ATP-sensitive Potassium Channel ATP Sensitivity Varies with the Type of SUR Subunit* (2001) (33)
Switching to Sulphonylureas in Children With iDEND Syndrome Caused by KCNJ11 Mutations Results in Improved Cerebellar Perfusion (2013) (33)
Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels. (2001) (33)
A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1 (2013) (33)
Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2 (2001) (32)
Life at the Extremes: The Science of Survival (2001) (32)
The essential role of the Walker A motifs of SUR 1 in K-ATP channel activation by Mg-ADP and diazoxide result in the closure of K-ATP channels in the β-cell plasma (1997) (32)
Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels (2006) (32)
Changes in Gene Expression Associated with FTO Overexpression in Mice (2014) (32)
Kir6.2‐dependent high‐affinity repaglinide binding to β‐cell KATP channels (2005) (31)
Gating of a muscle K+ channel and its dependence on the permeating ion species (1981) (31)
Inhibition of ATP‐sensitive potassium channels by haloperidol (2004) (30)
Mutational Analysis of CLC-5, Cofilin and CLC-4 in Patients with Dent’s Disease (2009) (30)
Autosomal Dominant Hypercalciuria in a Mouse Model Due to a Mutation of the Epithelial Calcium Channel, TRPV5 (2013) (30)
Heteromeric channel formation and Ca2+‐free media reduce the toxic effect of the weaver Kir 3.2 allele (1996) (29)
Tolbutamide reverses membrane hyperpolarisation induced by activation of D2 receptors and GABAB receptors in isolated substantia nigra neurones (1990) (29)
Quantal analysis of 5‐hydroxytryptamine release from mouse pancreatic β‐cells (1999) (29)
Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy. (2007) (29)
Low‐voltage‐activated A‐current controls the firing dynamics of mouse hypothalamic orexin neurons (2004) (29)
A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications (2008) (29)
Block of ATP‐sensitive K+ channels in isolated mouse pancreatic β‐cells by 2,3‐butanedione monoxime (1993) (29)
Effects of intracellular pH on ATP‐sensitive K+ channels in mouse pancreatic beta‐cells. (1994) (28)
Amantadine and sparteine inhibit ATP‐regulated K‐currents in the insulin‐secreting β‐cell line, HIT‐T15 (1991) (28)
A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse (2010) (28)
The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener. (2002) (28)
Pharmacological Inhibition of FTO (2015) (28)
No Evidence for Mutations in a Putative β-Cell ATP-Sensitive K+ Channel Subunit in MODY, NIDDM, or GDM (1995) (27)
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population (2003) (26)
Two types of Ca channel in rat pancreatic β-cells (2004) (26)
Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia (2018) (26)
Ca 2+ -activated K + channels (2000) (25)
T-system optical signals associated with inward rectification in skeletal muscle (1983) (25)
Analysis of the differential modulation of sulphonylurea block of β‐cell and cardiac ATP‐sensitive K+ (KATP) channels by Mg‐nucleotides (2003) (25)
Mutations of the Same Conserved Glutamate Residue in NBD2 of the Sulfonylurea Receptor 1 Subunit of the KATP Channel Can Result in Either Hyperinsulinism or Neonatal Diabetes (2011) (23)
Metabolic Regulation of the Pancreatic -Cell ATP-Sensitive K Channel (2004) (23)
Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk (2016) (23)
An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1. (2009) (23)
A potassium channel modulated by glucose metabolism in rat pancreatic beta-cells. (1986) (21)
Variable phenotypic spectrum of diabetes mellitus in a family carrying a novel KCNJ11 gene mutation (2008) (21)
Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats (2008) (21)
Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes (2014) (21)
The Nucleotide-Binding Sites of SUR1: A Mechanistic Model (2015) (21)
ATP-sensitive K-channels in HIT T15 β-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding (1989) (20)
MgATP activates the b cell KATP channel by interaction with its SUR 1 subunit (1998) (20)
In vitro mechanism of action on insulin release of S‐22068, a new putative antidiabetic compound (1999) (20)
Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: A mechanistic study (2014) (20)
Interaction between mutations in the slide helix of Kir6.2 associated with neonatal diabetes and neurological symptoms. (2010) (19)
Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic beta-cells. (1999) (19)
Voltage-gated Na + channels (2000) (19)
Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin‐secreting β‐cell line, HIT T15 (1988) (19)
Low extracellular magnesium does not impair glucose-stimulated insulin secretion (2019) (18)
The ATP- and tolbutamide-sensitivity of the ATP-sensitive K-channel from human pancreatic B cells (1989) (18)
The beta-cell sulfonylurea receptor. (1993) (18)
Functional analysis of two Kir6.2 (KCNJ11) mutations, K170T and E322K, causing neonatal diabetes (2007) (18)
The influence of the permeant ions thallous and potassium on inward rectification in frog skeletal muscle. (1983) (18)
ATP-sensitive K channels in guinea-pig isolated substantia nigra neurones are modulated by cellular metabolism (1990) (17)
Two types of Ca channel in rat pancreatic beta-cells. (1990) (17)
A mutation causing increased KATP channel activity leads to reduced anxiety in mice (2014) (17)
FTO demethylase activity is essential for normal bone growth and bone mineralization in mice (2018) (17)
Magnesium deficiency prevents high-fat-diet-induced obesity in mice (2018) (16)
Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8lc00417j (2018) (16)
A conserved tryptophan at the membrane–water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated (2011) (16)
Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding (2018) (16)
Interaction of stilbene disulphonates with cloned KATP channels (2001) (16)
Glucose regulates the effects of leptin on hypothalamic POMC neurons (2008) (16)
Inactivation of calcium currents in skeletal muscle fibres of an insect depends on calcium entry (1980) (16)
Gap junction channels (2000) (15)
Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes (2003) (15)
Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies (2010) (15)
A mutation in the ATP‐binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit (2007) (15)
THE GLUCOSE-SENSITIVE POTASSIUM CHANNEL IN RAT PANCREATIC BETA-CELLS IS INHIBITED BY INTRACELLULAR ATP (1985) (15)
Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas. (2002) (14)
A microflow superfusion system for use with excised membrane patches (1987) (14)
INWARD RECTIFICATION IN SKELETAL MUSCLE FIBRES (1981) (14)
Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BΔ31 (2002) (14)
Interaction of Vanadate with the Cloned Beta Cell KATP Channel* (1999) (14)
The effect of tolbutamide on cerebral blood flow during hypoxia and hypercapnia in the anaesthetized rat (1993) (13)
EFFECTS OF INTERNAL MG-2+ ON ATP-SENSITIVE K-CHANNELS IN ISOLATED RAT PANCREATIC B-CELLS (1987) (13)
Mosaic Paternal Uniparental Isodisomy and an ABCC8 Gene Mutation in a Patient With Permanent Neonatal Diabetes and Hemihypertrophy (2008) (13)
Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+ (2018) (13)
Binding of sulphonylureas to plasma proteins – A KATP channel perspective (2018) (13)
An ABCC8 Nonsense Mutation Causing Neonatal Diabetes Through Altered Transcript Expression (2017) (13)
Transporters, channels and human disease. (1993) (13)
NEM modification prevents high‐affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1 (1999) (13)
Stimulus-Secretion Coupling in Pancreatic p Cells (1994) (13)
Direct interaction of Na‐azide with the KATP channel (2000) (12)
Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry (2019) (12)
CHAPTER 27 – THE SULFONYLUREA RECEPTOR: AN ABCC TRANSPORTER THAT ACTS AS AN ION CHANNEL REGULATOR (2003) (12)
Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles (2013) (11)
Calcium Action Potentials in the Skeletal Muscle Fibres of the Stick Insect Carausius Morosus (1981) (11)
The Ba2+ block of the ATP-sensitive K+ current of mouse pancreaticβ-cells (1996) (11)
Modification of K-ATP channels in pancreatic beta-cells by trypsin. (1993) (11)
Determination of the molecular mass of the native β‐cell sulfonylurea receptor (1994) (10)
Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels (2016) (10)
Epithelial Na + channel (2000) (10)
Evaluating inositol phospholipid interactions with inward rectifier potassium channels and characterising their role in disease (2020) (10)
Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels. (2005) (10)
Modification of K-ATP channels in pancreatic β-cells by trypsin (1993) (10)
Ca2+ channels and excitation-contraction coupling. (1991) (10)
The Kir6.2‐F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits (2007) (9)
The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids. (2010) (9)
Gain-of-Function Mutations in the KATP Channel (KCNJ11) Impair Coordinated Hand-Eye Tracking (2013) (9)
Single Calcium Channel Activity in Mouse Pancreatic β‐Cells (1989) (9)
How ion channels work (2000) (9)
A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening (2012) (9)
THE EFFECT OF CHANGES IN INTRACELLULAR ATP CONCENTRATION ON THE ACTIVITIES OF ATP-SENSITIVE K-CHANNELS AND OF NA-K-ATPASE IN INTACT HIT-T15 B-CELLS (1989) (9)
Shedding new light on brain metabolism and glial function (2002) (8)
Human a-endosulfine , a possible regulator of sulfonylurea-sensitive KATP channel : Molecular cloning , expression and biological properties (1998) (8)
The Yin and Yang of the K(ATP) channel. (2000) (8)
The Ba 2 + block of the ATP-sensitive K + current of mouse pancreatic b-cells (8)
The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C‐terminal 42 amino acids (2010) (8)
Inwardly rectifying K + channels (2000) (7)
Voltage-gated K + channels (2000) (7)
Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment (2018) (7)
Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31. (2002) (7)
Mice expressing a human KATP channel mutation have altered channel ATP sensitivity but no cardiac abnormalities (2012) (7)
THE ROLE OF THE ATP-SENSITIVE K-CHANNEL IN STIMULUS-RESPONSE COUPLING IN THE PANCREATIC BETA-CELL (1989) (7)
Keeping the heart going: a new role for KATP channels (2006) (6)
The KCNJ11-E23K Gene Variant Hastens Diabetes Progression by Impairing Glucose-Induced Insulin Secretion (2021) (6)
Calcium currents in insulin-secreting beta-cells. (1989) (6)
The Ba2+ block of the ATP-sensitive K+ current of mouse pancreatic beta-cells. (1996) (6)
RUBIDIUM ACTS AS A PERMEANT BLOCKER OF THE GLUCOSE AND ATP-SENSITIVE K-CHANNEL IN RAT PANCREATIC BETA-CELLS (1986) (6)
Tolbutamide reverses hypoglycaemia-induced hyperpolarization in guinea-pig isolated substantia nigra neurones (1990) (6)
Studying ion channels (2000) (6)
The Electrical Constants of the Skeletal Muscle Fibres of the Stick Insect, Carausius Morosus (1980) (6)
From gene to protein (2000) (5)
The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel (2021) (4)
Sweet news for hypoglycemic babies (1996) (4)
Mouse Models of β-cell KATP Channel Dysfunction. (2013) (4)
Role of the C‐terminus of SUR in the differential regulation of β‐cell and cardiac KATP channels by MgADP and metabolism (2018) (4)
Ion channels in lymphocytes. (1984) (4)
Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells (2022) (4)
Cystic fibrosis transmembrane conductance regulator (2000) (4)
Heterogeneity of beta-cell Ca2+ responses to glucose. (1997) (4)
Effects of protein phosphorylation on the sulphonylurea receptor of the pancreatic beta-cell. (1997) (4)
REDUCED INTERNAL ATP CONCENTRATIONS AND MITOCHONDRIAL INHIBITION ACTIVATE K+-ATP CHANNELS IN ISOLATED DOPAMINERGIC SUBSTANTIA-NIGRA NEURONS FROM THE RAT (1993) (4)
CATIONIC AMINO-ACID TRANSPORTERS EXPRESSED IN PANCREATIC BETA-CELLS (1995) (4)
Lipid remodelling and an altered membrane proteome may drive the effects of EPA and DHA treatment on skeletal muscle glucose uptake and protein accretion (2017) (4)
Two types of potassium channel regulated by ATP in pancreatic B cells isolated from a type-2 diabetic human (1993) (4)
Potassium channel regulation Structural insights into the function of the nucleotide-binding domains of the human sulphonylurea receptor (2013) (4)
Calcium currents of frog and insect skeletal muscle fibres measured during voltage clamp. (1982) (3)
THE EFFECT OF INTRACELLULAR PH ON ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS (1993) (3)
Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail? (2019) (3)
OXIDATIVE STRESS REDUCES FAST INACTIVATION OF AN A-CURRENT IN ISOLATED DOPAMINERGIC SUBSTANTIA-NIGRA NEURONS FROM RAT (1994) (3)
Heterogeneity of beta-cell secretion. Possible involvement of K-ATP channels. (1997) (3)
EXOCYTOSIS MONITORED BY SIMULTANEOUS MEASUREMENT OF CELL CAPACITANCE AND 5-HT RELEASE IN ISOLATED MOUSE PANCREATIC BETA-CELLS (1994) (3)
The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation (2015) (3)
Crystal structure of an inward rectifier potassium channel (2003) (3)
TOLBUTAMIDE, AN INHIBITOR OF ATP-SENSITIVE K-CHANNELS, EXCITES CAROTID-BODY CHEMORECEPTORS IN THE CAT (1987) (3)
INACTIVATION OF CALCIUM CURRENTS IN INSECT SKELETAL MUSCLE (1981) (3)
Determination of the molecular mass of the native beta-cell sulfonylurea receptor. (1994) (3)
Heterogeneity of β-Cell Secretion (1997) (3)
INWARD RECTIFICATION IN THE T-SYSTEM OF FROG SKELETAL-MUSCLE (1983) (3)
A cytosolic factor that inhibits KATP channels expressed in Xenopus oocytes by impairing Mg‐nucleotide activation by SUR1 (2009) (3)
A mouse model of neonatal diabetes caused by the K-ATP channel mutation Kir6.2-V59M (2008) (3)
Effects of internal chloride on ATP-sensitive K-channels in mouse pancreatic β-cells (1994) (2)
Coincidence of a Novel KCNJ11 Missense Variant R365H With a Paternally Inherited 6q24 Duplication in a Patient With Transient Neonatal Diabetes (2008) (2)
VOLTAMMETRIC MONITORING OF 5-HT SECRETION FROM ISOLATED MOUSE PANCREATIC BETA-CELLS (1994) (2)
The spark of life (2014) (2)
ATP-SENSITIVE K-CHANNELS IN HIT-T15 INSULIN SECRETING CELLS (1988) (2)
2 CATIONIC AMINO-ACID TRANSPORTERS EXPRESSED IN PANCREATIC BETA-CELLS (1995) (2)
VOLTAGE-ACTIVATED CALCIUM AND POTASSIUM CURRENTS IN HUMAN ISOLATED PANCREATIC BETA-CELLS (1989) (2)
Monitoring glycolytic dynamics in single cells using a fluorescent biosensor for fructose 1,6-bisphosphate (2022) (2)
MOBILIZATION OF INTRACELLULAR CALCIUM BY CAFFEINE IN SINGLE-MOUSE PANCREATIC BETA-CELLS (1995) (2)
Ca2+-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers (1992) (2)
Phentolamine block of ATP-sensitive K+ channels does not involve interaction with the sulphonylurea receptor, SUR1. (1997) (2)
Cell-attached patch recordings from single cells isolated from guinea-pig substantia nigra (1987) (2)
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population (2003) (2)
Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP (2001) (1)
Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time. (2020) (1)
Calcium currents in insect muscle [proceedings]. (1979) (1)
Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail? (2019) (1)
Rosalind Franklin and Photograph 51 (2015) (1)
Potent and selective activation of beta-cell Type ATP-sensitive potassium channels by NN414, a novel diazoxide analogue. (2002) (1)
Chapter 15 – Acetylcholine receptors (2000) (1)
Isolation and characterization of single neurones from guinea-pig substantia nigra (1990) (1)
The antimalarial drugs mefloquine and halofantrine inhibit ATP-sensitive potassium channels (1997) (1)
Rapid Publication I d e n t i fication of the High-Affinity Tolbutamide Site on the SUR1 Subunit of the K AT P C h a n n e l (1999) (1)
Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice (2020) (1)
EFFECTS OF DIVALENT-CATIONS ON SECRETION FROM ISOLATED MOUSE PANCREATIC BETA-CELLS (1994) (1)
Mapping the architecture of the ATP-binding site of Kir6.2 (2002) (1)
GLUCOSE MODULATES L-TYPE CA CHANNELS IN MURINE ISOLATED PANCREATIC BETA-CELLS (1989) (1)
Thiol reagents and ATP do not interact with C717 in the SUR1 subunit of the beta-cell K-ATP channel (1997) (1)
Metabolic regulation of insulin secretion in health and disease (2021) (1)
Characterisation of new K-ATP-channel mutations associated with congenital hyperinsulinism in the Finnish population (vol 46, pg 241, 2003) (2004) (1)
HUMAN PANCREATIC B-CELLS POSSESS 2 TYPES OF CA-CHANNEL (1992) (1)
Protein kinase C does not influence the tolbutamide sensitivity of K-ATP currents (1996) (1)
Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1B D 31 (2002) (1)
ATP-SENSITIVE POTASSIUM CHANNELS AND DIABETES: FROM MOLECULE TO MALADY (2009) (1)
Dissection-independent production of Plasmodium sporozoites from whole mosquitoes (2021) (1)
Correction to ‘Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels’ (2016) (1)
Voices: Insulin and beyond. (2021) (1)
Enhanced PIP3 signaling in POMC neurons causes diet-sensitive obesity as the consequence of neuronal silencing via KATP channel activation (2006) (1)
Stimulation of insulin release by a new compound S-22068. Evidence for a novel imidazoline binding site in beta cells (1998) (1)
FURTHER-STUDIES OF ATP-MODULATION OF K-CHANNELS IN RAT ISOLATED PANCREATIC-B CELLS (1987) (1)
Molecular basis of Kir6.2 mutations causing neonatal diabetes and neonatal diabetes with neurological features (2005) (1)
ATP-regulated K channels modulate electrical activity in mouse isolated pancreatic β-cells (1990) (1)
MODULATION OF L-TYPE CA CHANNELS IN MURINE PANCREATIC B-CELLS BY GLUCOSE-METABOLISM (1989) (1)
Inspiring the scientists of tomorrow (2013) (0)
Does Nicotinamide nucleotide transhydrogenase have a role in insulin secretion (2005) (0)
Voltage-gated Ca 2+ channels (2000) (0)
An Infant with a Novel Kir6.2 Mutation Causing Neonatal Diabetes and Unexplained Lack of Response to Sulphonylurea (2014) (0)
Q&A: insulin secretion and type 2 diabetes: why do β-cells fail? (2015) (0)
Dissection-independent production of a protective whole-sporozoite malaria vaccine (2020) (0)
Nucleotide Modulation of KATP Channels Disentangled with FRET (2019) (0)
DIFFERENT TYPES OF MEMBRANE RETRIEVAL IN SINGLE-MOUSE PANCREATIC BETA-CELLS (1995) (0)
Differential activation of cloned K-ATP channels by nicorandil (2001) (0)
EXOCYTOSISELICITEDBY ACTION POTENTIALSAND VOLTAGE- CLAMP CALCIUM CURRENTS ININDIVIDUALMOUSE PANCREATIC B-CELLS (1993) (0)
SUR mutation in type 1 diabetes: autoimmunity prevents sulfonylurea rescue of diabetes caused by SUR1 mutation. Results from the Hvidore Study Group (2008) (0)
Cellular Neurophysiology C37‐C58, PC19‐PC32 (2004) (0)
Visualizing Adenine Nucleotide Regulation of the K ATP Channel (2018) (0)
Women in Metabolism: Part 3. (2015) (0)
ATP-sensitive potassium channels and neonatal diabetes: a treatable channelopathy (2011) (0)
THE ROLE OF ION CHANNELS IN STIMULUS-SECRETION COUPLING IN PANCREATIC BETA-CELLS (1990) (0)
C 24 Calcineurin A α regulates Kir 6 . 1 / SUR 2 B in HEK 293 cells through an interaction with protein kinase A (2005) (0)
C 24 Calcineurin A α regulates Kir 6 . 1 / SUR 2 B in HEK 293 cells through an interaction with protein kinase A (2005) (0)
RUNDOWN OF ATP-SENSITIVE K-CURRENTS IN MOUSE PANCREATIC BETA-CELLS (1992) (0)
Differential Nucleotide Activation of Kir6.2/SUR2A (Cardiac) and Kir6.2/SUR2B (Smooth Muscle) KATP Channels (2001) (0)
SINGLE CHANNEL RECORDINGS FROM HUMAN ISOLATED PANCREATIC B-CELLS (1987) (0)
New insights into the tissue specificity of sulphonylureas (2001) (0)
Probing the structure and function of the K-ATP channel with thiol reagents. (2001) (0)
Mouse models of b-cell K ATP channel (2013) (0)
The ATP-sensitive potassium channel: a metabolic sensor (2001) (0)
Chapter 16 – Glutamate receptors (2000) (0)
A ragbag of channels (2000) (0)
Correction: Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents (2019) (0)
Cloning of the human SUR1 and Kir6.2 gene promoters (1997) (0)
Interactions between nicorandil and sulphonylureas: a structural basis. (2001) (0)
Functional coupling between Kir6.2 and SUR1 is prerequisite for [H-3]repaglinide, but not [H-3]glibenclamide, binding to pancreatic ATP-sensitive potassium (K-ATP) channels. (2003) (0)
A model for regulation of the beta-cell ATP-sensitive K+-channel by nucleotides and diazoxide. (1997) (0)
IMPAIRED BETA-CELL FUNCTION BUT NOT SELECTIVE GLUCOSE INSENSITIVITY IN DIET-TREATED TYPE-2 DIABETIC SUBJECTS (1993) (0)
CORRELATION OF INTERNAL CALCIUM TRANSIENTS, EXOCYTOSIS AND THE RELEASE OF GRANULE CONTENTS IN PANCREATIC BETA-CELLS (1994) (0)
Successful therapy with glibenclamid in a patient with a muation of KIR 6.2 subunit of the ATP-sensitive potassium channel (2006) (0)
Hyperglycaemia adversely affects mitochondrial function in pancreatic islets (2018) (0)
Dominantly inherited form of hyperinsulinism caused by a gene mutation in the sulfonylurea receptor 1 (2000) (0)
Regulation of K-ATP channels by nucleotides and drugs (2000) (0)
Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With KCNJ11-Related Neonatal Diabetes. Diabetes Care 2014;37:3333–3335 (2019) (0)
CHARACTERIZATION OF AN INWARDLY RECTIFYING K+ CHANNEL EXPRESSED IN PANCREATIC BETA-CELLS (1995) (0)
EFFECTS OF TRYPSIN ON ATP-DEPENDENT-K+ CHANNELS FROM PANCREATIC BETA-CELLS (1992) (0)
The open state of KirBac3.1 observed by cryo-electron microscopy (2007) (0)
Insulin Induced Hypoglycemia: Shedding Light on the Role of Somatostatin (2014) (0)
Regulation of insulin and glucagon secretion in a mouse model of neonatal diabetes (2013) (0)
Insulin prevents counter-regulatory glucagon secretion by stimulation of somatostatin release (2013) (0)
High Resolution AFM of KcsA Structure and Clustering in a Lipid Bilayer (2009) (0)
Erratum: Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects (Diabetes (2006) 55, (1705-1712)) (2007) (0)
Ion channels as lethal agents (2000) (0)
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion (2019) (0)
EFFECTS OF MAGNESIUM-IONS ON ATP-SENSITIVE K-CHANNELS FROM RAT PANCREATIC B-CELLS (1988) (0)
DETERMINATION OF THE MOLECULAR-MASS OF THE BETA-CELL SULFONYLUREA RECEPTOR (1993) (0)
Ba currents through L-type Ca channels in isolated mouse pancreatic β-cells (1991) (0)
Oxygen Consumption Rate (OCR), Extracellular Acidification Rate (ECAR) of C2C12, and wild-type and FTO knockout MEFs treated with 1 μM IOX3 or an equivalent amount of vehicle control for 16 hours. (2015) (0)
A mutation in the ATP-binding site of the K-ATP channel alters coupling with SUR2A (2007) (0)
Gaba A receptors (2000) (0)
Twenty questions: Highlighting the pitfalls and possibilities of drug research (2004) (0)
DUAL EFFECTS OF PROTEIN-PHOSPHORYLATION ON THE BINDING-ACTIVITY OF THE SULFONYLUREA RECEPTOR (1992) (0)
Dynamic sensitivity of K-ATP channels to ATP (2001) (0)
Modern concepts on the molecular mechanisms of sulfonylurea effect on KITP channels (2001) (0)
CA-INDEPENDENT STIMULATION OF EXOCYTOSIS BY GTP IN SINGLE-MOUSE PANCREATIC BETA-CELLS (1994) (0)
Investigation of Protonation Effects on ATP Binding in ABC Transporters (2010) (0)
Inhibition of cloned K-ATP channels by stilbene disulphonates (2000) (0)
ADP MODULATES THE ATP-SENSITIVITY OF THE K-CHANNEL CLOSED BY GLUCOSE IN ISOLATED RAT PANCREATIC B-CELLS (1986) (0)
Gating and ATP-sensitivity of the cloned beta-cell K-ATP channel (1998) (0)
Differential Metabolic and Nucleotide Sensitivity of Beta-Cell and Cardiac K ATP Channels (2018) (0)
The role of nicotinamide nucleotide transhydrogenase in insulin secretion and impaired glucose tolerance (2005) (0)
Erratum: Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel (British Journal of Pharmacology (2001) 132 (1542-1548)) (2011) (0)
Rat isolated pancreatic β-cells possess both L- and T-type Ca channels (1990) (0)
Stochastic Switching Into Hydrolytically Active Conformations In A Homodimeric ABC Exporter (2009) (0)
KATP channels and insulin secretion (2012) (0)
Glucokinase activity in diabetes: too much of a good thing? (2022) (0)
Influences: Find a friend (2018) (0)
ATP-sensitive K + channels : a link between B-cell metabolism and insulin secretion 109 (2009) (0)
A High-Throughput Assay for Modulators of NNT Activity in Permeabilized Yeast Cells (2011) (0)
Two novel Kir6.2 mutations affecting the ATP sensitivity of the K-ATP channel are the cause of Permanent Neonatal Diabetes. (2005) (0)
Studies on Cloned Cardiac and -Cell K AT P C h a n n e l s (1998) (0)
Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons (Journal of Neuroscience (July 4, 2007) (7125-7129)) (2008) (0)
Modulation of gating of the cloned beta-cell K-ATP channel (1998) (0)
A novel SUR1/Kir6.2 specific K-ATP channel opener (2001) (0)
Two types of gating in inward rectifiers: The case of the K-ATP channel. (2001) (0)
Patch-Clamp Fluorometry Defines a Role for SUR1 in Nucleotide Inhibition of KATP Channels (2020) (0)
The extent of K-ATP channel block by MgATP correlates with the clinical phenotype caused by gain-of-function KCNJ11 mutations (2005) (0)
Chapter 19 – Water channels (2000) (0)
Ligand-gated Ca 2+ channels (2000) (0)
MgADP hydrolysis is required for MgADP activation of the cloned beta-cell K-ATP channel expressed in Xenopus oocytes (1997) (0)
Structure-function studies of the fast gating kinetics of the cloned ATP-sensitive potassium channel, Kir6.2/SUR1 (2001) (0)
The anti-malarial drugs Mefloquine and Halofantrine inhibit ATP-sensitive potassium channels (1997) (0)
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells (2019) (0)
INWARDLY RECTIFYING K+ CURRENTS IN OOCYTES CO-EXPRESSING KIR3.1 AND KIR3.2 (1995) (0)
Investigating the PIP2 Binding Site in Kir Channels Via Multi-Scale Biomolecular Simulations (2010) (0)
Nucleotide modulation of pinacidil stimulation of cloned KATP channels (2000) (0)
SUBSTRATE-DEPENDENT CHANGES IN MITOCHONDRIAL-FUNCTION, [CA-2+]I AND KATP CHANNELS IN MOUSE PANCREATIC BETA-CELLS INVITRO (1993) (0)
Cell Metabolism Glycolysis Control of b Cell Regeneration and Mass (2011) (0)
NO EVIDENCE FOR MUTATIONS IN THE BETA-CELL ATP-SENSITIVE POTASSIUM CHANNEL IN MODY, NIDDM OR GESTATIONAL DIABETES (1995) (0)
Ca(2+)-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers. (1990) (0)
Erratum: Glucose regulates the effects of leptin on hypothalamic POMC neurons (Proceedings of the National Academy of Sciences of the United States of America (2008) 105 (9811-9816)) (2009) (0)
THE EFFECT OF INTRACELLULAR PROTONS ON ATP-SENSITIVE K+ CHANNELS IN MOUSE PANCREATIC BETA-CELLS (1993) (0)
Dual effects of Na-azide on the whole-cell K-ATP current in isolated mouse pancreatic beta-cells (1997) (0)
Functional analysis of a mutant sulphonylurea receptor associated with a mild form of persistent hyperinsulinaemic hypoglycaemia of infancy (2000) (0)
Interaction of MgATP with the sulphonylurea subunit activates ATP sensitive K-channels receptor (1998) (0)
Transient receptor potential cation channel, subfamily Vanilloid, member 5 (Trpv5) mutation (Ser682Pro) results in loss of apical membrane expression in the distal convoluted tubule, thereby resulting in hypercalciuria (2010) (0)
Endocytosis involves a CLC-5 and KIF3B interaction: relevance to thyroid and renal tubular function (2008) (0)
INWARD RECTIFICATION IN FROG-MUSCLE - FURTHER ANALYSIS OF ITS EFFECT ON RADIAL POTENTIAL SPREAD (1984) (0)
PERMEABILITY OF SINGLE GLUCOSE-SENSITIVE K-CHANNEL TO RUBIDIUM IONS (1986) (0)
Contents Vol. 112, 2009 (2009) (0)
Exocytosis in isolated mouse pancreatic beta-cells (1996) (0)
Cyclic nucleitide-gated channels (2000) (0)
Chapter 17 – Glycine receptors (2000) (0)
PERSPECTIVES (2000) (0)
A variant of SUR1 may constitute part of the ATP-sensitive potassium channel of hypothalamic neurons (1999) (0)
Autoantibodies to ion channels (2000) (0)
Markedly Increased Repaglinide Binding Affinity for SUR1 by Co-Expression with Kir6.2 (2002) (0)
Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice. (2020) (0)
Mechanism of K-ATP channel inhibition by ATP (1998) (0)
Different effects of insulin on electrically distinct hypothalamic arcuate nucleus (ARC) neurones (2002) (0)
High-affinity block of K-ATP channels of mouse isolated pancreatic beta-cells but not rat heart or arterial smooth muscle cells by the sulphonylurea gliclazide (2001) (0)
A novel role for FTO in adipogenesis (2014) (0)
thrifty phenotype: effect of gender glycerol-3-phosphate dehydrogenase gene exhibit a Mice with deletion of the mitochondrial (2006) (0)
Retractions and Correction (2009) (0)
Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels. (2001) (0)
L-TYPE CA-CHANNEL ACTIVITY RECORDED AT A LOW DIVALENT-CATION CONCENTRATION (1991) (0)
Metabolic regulation of cloned KATP channels expressed in Xenopus oocytes (2001) (0)
The functional effects of naturally occurring KNCJ11 mutations associated with neonatal diabetes on cloned cardiac K-ATP channels (2005) (0)
The N-terminus of Kir6.2 is involved in coupling to SUR1 (1999) (0)
A Novel, Spectroscopic Window into Nucleotide Activation of KATP Channels (2017) (0)
Voltage-gated Cl − channels (2000) (0)
ATP-dependent interaction of the cytosolic domains of Kir6.2 revealed by fluorescence resonance energy transfer (2003) (0)
Permanent neonatal diabetes caused by an in-frame deletion in the N-terminus of Kir6.2 (2008) (0)
Modulation of tolbutamide sensitivity of K-ATP currents in mouse pancreatic beta-cells by intracellular nucleotides and magnesium (1996) (0)
Photoaffinity Labeling of Kir 6 . 2 y [ g-32 P ] ATP-[ g ] 4-Azidoanilide (2000) (0)
A dominant mutation in the obesity susceptibility gene FTO results in reduced fat mass with enhanced lipid and carbohydrate metabolism (2009) (0)
Molecular and biophysical identity of orexin/hypocretin neurons (2004) (0)
Retraction for Ma et al., Glucose regulates the effects of leptin on hypothalamic POMC neurons (2009) (0)
GLUCOSE INHIBITS POTASSIUM CHANNEL ACTIVITY IN SINGLE-RAT PANCREATIC-ISLET CELLS (1985) (0)
Understanding Molecular Mechanisms for Diabetes and Obesity through Mouse Models (2014) (0)
How does chronic hyperglycaemia impair-cell metabolism and thereby induce loss of both-cell function and-cell mass ? (2017) (0)
The sulphonylurea receptor (SUR): how does an ABC transporter regulate a K+ channel? (2010) (0)
Interactions between tolbutamide and nucleotides on cloned K-ATP channels. (1997) (0)

This paper list is powered by the following services:

Other Resources About Frances Ashcroft

en.wikipedia.org

What Schools Are Affiliated With Frances Ashcroft?

Frances Ashcroft is affiliated with the following schools:

Frances Ashcroft's Academic­Influence.com Rankings

Why Is Frances Ashcroft Influential?

Frances Ashcroft's Published Works

Published Works

Other Resources About Frances Ashcroft

What Schools Are Affiliated With Frances Ashcroft?

Frances Ashcroft's AcademicInfluence.com Rankings