Frances M. Leslie
#163,156
Most Influential Person Now
Frances M. Leslie's AcademicInfluence.com Rankings
Frances M. Lesliemedical Degrees
Medical
#3315
World Rank
#3782
Historical Rank
Pharmacology
#410
World Rank
#463
Historical Rank

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Medical
Frances M. Leslie's Degrees
- PhD Pharmacology University of California, Irvine
- Bachelors Biological Sciences University of California, Irvine
Why Is Frances M. Leslie Influential?
(Suggest an Edit or Addition)Frances M. Leslie's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Brain monoglyceride lipase participating in endocannabinoid inactivation (2002) (1301)
- Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus (2002) (697)
- Distribution of dynorphin and enkephalin peptides in the rat brain (1986) (519)
- The dynamic effects of nicotine on the developing brain. (2009) (509)
- EFFECT OF MORPHINE ON ADRENERGIC TRANSMISSION IN THE MOUSE VAS DEFERENS. ASSESSMENT OF AGONIST AND ANTAGONIST POTENCIES OF NARCOTIC ANALGESICS (1975) (391)
- Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain (2001) (356)
- Dependence of Olfactory Bulb Neurogenesis on Prokineticin 2 Signaling (2005) (308)
- Nicotine and the adolescent brain (2015) (306)
- Trophic stimulation of cultured neurons from neonatal rat brain by epidermal growth factor. (1987) (295)
- Impulsive and Self-Conscious: Adolescents' Vulnerability to Advertising and Promotion (2005) (288)
- Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats (2004) (279)
- Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons (2002) (259)
- Nicotine and brain development. (2008) (248)
- Acetaldehyde Enhances Acquisition of Nicotine Self-Administration in Adolescent Rats (2005) (238)
- Methods used for the study of opioid receptors. (1987) (221)
- Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain. (1987) (196)
- Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. (2005) (189)
- ASSESSMENT IN THE GUINEA‐PIG ILEUM AND MOUSE VAS DEFERENS OF BENZOMORPHANS WHICH HAVE STRONG ANTINOCICEPTIVE ACTIVITY BUT DO NOT SUBSTITUTE FOR MORPHINE IN THE DEPENDENT MONKEY (1975) (174)
- Postnatal development of multiple opioid receptors in rat brain. (1987) (154)
- Smoking to self-medicate attentional and emotional dysfunctions. (2007) (152)
- Pharmacological evidence for alpha-2 adrenoceptor heterogeneity: differential binding properties of [3H]rauwolscine and [3H]idazoxan in rat brain. (1987) (145)
- Developmental expression ofα7 neuronal nicotinic receptor messenger RNA in rat sensory cortex and thalamus (1995) (137)
- Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons (2007) (129)
- Regulation of α7 Nicotinic Acetylcholine Receptors in the Developing Rat Somatosensory Cortex by Thalamocortical Afferents (1996) (128)
- Co-expression of α7 and β2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons (2003) (126)
- Codistribution of nicotinic acetylcholine receptor subunit α3 and β4 mRNAs during rat brain development (1997) (126)
- Behavioral effects and in vivo degradation of intraventricularly administered dynorphin-(1-13) and D-Ala2-dynorphin-(1-11) in rats. (1980) (124)
- A Critical Period for Nicotine-Induced Disruption of Synaptic Development in Rat Auditory Cortex (2000) (116)
- Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. (2007) (116)
- Differential appearance of opiate receptor subtypes in neonatal rat brain. (1982) (115)
- Expression of α 2 adrenoceptors during rat brain development—I. α 2A messenger RNA expression (1996) (104)
- Ascorbate Decreases Ligand Binding to Neurotransmitter Receptors (1980) (102)
- Expression of prokineticins and their receptors in the adult mouse brain (2006) (102)
- Opioid activities of fragments of beta-endorphin and of its leucine65-analogue. Comparison of the binding properties of methionine- and leucine-enkephalin. (1979) (100)
- Noradrenergic changes and memory loss in aged mice (1985) (100)
- Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formation. (2002) (97)
- Effects of morphine on DNA synthesis in neonatal rat brain. (1987) (93)
- Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites. (1980) (92)
- Adolescent Development of Forebrain Stimulant Responsiveness: Insights from Animal Studies (2004) (92)
- Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats (2006) (88)
- Expression of α 2 adrenoceptors during rat brain development—II. α 2C messenger RNA expression and [3H]rauwolscine binding (1996) (86)
- The alpha7 nicotinic acetylcholine receptor in neuronal plasticity. (1999) (86)
- The α7 nicotinic acetylcholine receptor in neuronal plasticity (1999) (85)
- Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons. (2003) (85)
- Monoamine Oxidase Inhibitors Allow Locomotor and Rewarding Responses to Nicotine (2006) (85)
- Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping population of neocortical neurons in vitro (1990) (84)
- Dynorphin-containing pathways in the substantia nigra and ventral tegmentum: A double labeling study using combined immunofluorescence and retrograde tracing (1985) (84)
- Expression of α5 nicotinic acetylcholine receptor subunit mRNA during hippocampal and cortical development (2005) (83)
- The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt (2012) (83)
- Neonatal treatment with 192 IgG-saporin produces long-term forebrain cholinergic deficits and reduces dendritic branching and spine density of neocortical pyramidal neurons. (1998) (82)
- AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats (2012) (76)
- Nicotinic Receptors in Addiction Pathways (2013) (72)
- Nicotine Alters Limbic Function in Adolescent Rat by a 5-HT1A Receptor Mechanism (2011) (71)
- Sex‐dependent effects of nicotine on the developing brain (2017) (71)
- Prenatal nicotine exposure changes natural and drug‐induced reinforcement in adolescent male rats (2008) (70)
- Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain (2019) (69)
- Gender Specific Effect of Neonatal Handling on Stress Reactivity of Adolescent Rats (2003) (69)
- Acetaldehyde, a Major Constituent of Tobacco Smoke, Enhances Behavioral, Endocrine, and Neuronal Responses to Nicotine in Adolescent and Adult Rats (2007) (65)
- COMPARISON OF THE RECEPTOR BINDING CHARACTERISTICS OF OPIATE AGONISTS INTERACTING WITH μ‐ OR K‐RECEPTORS (1978) (65)
- Highly sensitive radioactive in situ hybridization using full length hydrolyzed riboprobes to detect alpha 2 adrenoceptor subtype mRNAs in adult and developing rat brain. (1999) (65)
- Tobacco use across the formative years: a road map to developmental vulnerabilities. (2003) (64)
- Behavioral and receptor binding analysis of the α2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-YL amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an α2-adrenoceptor subtype (1991) (64)
- Comparison of the Reinforcing Properties of Nicotine and Cigarette Smoke Extract in Rats (2014) (64)
- Multigenerational epigenetic effects of nicotine on lung function (2013) (64)
- Tranylcypromine enhancement of nicotine self-administration (2007) (64)
- Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse (2017) (63)
- The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat (2001) (63)
- Postnatal development of opioid systems in rat brain (1985) (63)
- Ascorbate destruction of opiate stereospecific binding in guinea pig brain homogenate. (1979) (62)
- Both the sigma receptor-specific ligand (+)3-PPP and the PCP receptor-specific ligand TCP act in the mouse vas deferens via augmentation of electrically evoked norepinephrine release. (1987) (60)
- Adolescent Maturation of Cocaine-Sensitive Neural Mechanisms (2007) (59)
- Nicotine exposure during a postnatal critical period alters NR2A and NR2B mRNA expression in rat auditory forebrain. (2002) (56)
- α2B Adrenoceptor mRNA expression during rat brain development (1997) (53)
- Nicotine‐Stimulated Release of [3H]Norepinephrine from Fetal Rat Locus Coeruleus Cells in Culture (1998) (52)
- Localization of α7 nicotinic receptor subunit mRNA and α‐bungarotoxin binding sites in developing mouse somatosensory thalamocortical system (1995) (52)
- Regulation of Homer and group I metabotropic glutamate receptors by nicotine (2005) (50)
- Degradation of dynorphin-(1–13) by membrane-bound rat brain enzymes (1982) (48)
- Negative Allosteric Modulation of Nicotinic Acetylcholine Receptors Blocks Nicotine Self-Administration in Rats (2007) (47)
- Expression of alpha2A adrenoceptors during rat neocortical development. (1999) (46)
- Cholinergic binding sites in rat brain: Analysis by age and cognitive status (1995) (45)
- Locomotor and stress responses to nicotine differ in adolescent and adult rats (2010) (45)
- Rat ventral midbrain dopamine neurons express the orphanin FQ/nociceptin receptor ORL-1 (2002) (44)
- Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures (2002) (43)
- Unique, long-term effects of nicotine on adolescent brain (2020) (42)
- Neurochemical properties of the prolactin releasing peptide (PrRP) receptor expressing neurons: evidence for a role of PrRP as a regulator of stress and nociception (2002) (42)
- Developmental regulation of nicotinic acetylcholine receptor‐mediated [3H]norepinephrine release from rat cerebellum (2003) (41)
- Postnatal Development of NR2A and NR2B mRNA Expression in Rat Auditory Cortex and Thalamus (2002) (39)
- Opioid receptor and peptide mRNA expression in proliferative zones of fetal rat central nervous system. (1998) (39)
- 20 – Neurotransmitters as Neurotrophic Factors (1993) (38)
- Nicotine modulation of stress‐related peptide neurons (2006) (37)
- Age-dependent effects of low-dose nicotine treatment on cocaine-induced behavioral plasticity in rats (2009) (37)
- Expression of alpha 2 adrenoceptors during rat brain development--I. Alpha 2A messenger RNA expression. (1997) (37)
- Development of delta-opioid receptor subtypes and the regulatory role of weaning: radioligand binding, autoradiography and in situ hybridization studies. (1995) (36)
- Glial mechanisms underlying substance use disorders (2018) (36)
- Gestational nicotine treatment modulates cell death/survival-related pathways in the brains of adolescent female rats. (2011) (35)
- Cigarette Smoke Extract: A Preclinical Model of Tobacco Dependence (2016) (34)
- Gestational nicotine exposure modifies myelin gene expression in the brains of adolescent rats with sex differences (2013) (34)
- Adolescent Maturation of Dopamine D1 and D2 Receptor Function and Interactions in Rodents (2016) (34)
- kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures. (1992) (34)
- Nicotinic acetylcholine receptor-mediated release of [3H]norepinephrine from developing and adult rat hippocampus: direct and indirect mechanisms (2002) (34)
- Microglial activation increases cocaine self-administration following adolescent nicotine exposure (2020) (33)
- Reinforcing and neural activating effects of norharmane, a non-nicotine tobacco constituent, alone and in combination with nicotine (2014) (33)
- Rates of onset and offset of action of narcotic analgesics in isolated preparations. (1975) (32)
- Long-term changes in striatal opioid systems after 6-hydroxydopamine lesion of rat substantia nigra (1993) (32)
- Effect of acetylcholinesterase inhibitors on the binding of nicotinic α4β2 receptor PET radiotracer, 18F‐nifene: A measure of acetylcholine competition (2007) (29)
- Age influences the effects of nicotine and monoamine oxidase inhibition on mood-related behaviors in rats (2010) (28)
- Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat (2007) (27)
- Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats (2007) (27)
- Comparison of binding of [3H]-methionine-enkephalin, [3H]-naltrexone and [3H]-dihydromorphine in the mouse vas deferens and the myenteric plexus and brain of the ginea pig. (1979) (26)
- Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats. (2011) (26)
- Expression of opioid peptides and receptors in striatum and substantia nigra during rat brain development (2003) (25)
- Gestational exposure to nicotine and monoamine oxidase inhibitors influences cocaine-induced locomotion in adolescent rats (2007) (25)
- Calcium Regulation of Agonist Binding to α7‐Type Nicotinic Acetylcholine Receptors in Adult and Fetal Rat Hippocampus (1998) (25)
- Nicotine Increases Alcohol Intake in Adolescent Male Rats (2017) (25)
- Synthesis and Evaluation of Nicotine 42 Receptor Radioligand, 5-(3- 18 F-Fluoropropyl)-3- (2-(S)-Pyrrolidinylmethoxy)Pyridine, in Rodents and PET in Nonhuman Primate (2005) (25)
- N-[3H]methylscopolamine labeling of non-M1, non-M2 muscarinic receptor binding sites in rat brain. (1991) (23)
- Self-administration of nicotine and cigarette smoke extract in adolescent and adult rats (2016) (23)
- Gestational nicotine-induced changes in adolescent neuronal activity (2006) (23)
- Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse (2019) (23)
- Expression of alpha 2 adrenoceptors during rat brain development--II. Alpha 2C messenger RNA expression and [3H]rauwolscine binding. (1997) (23)
- The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition (2011) (22)
- Prenatal nicotine sex-dependently alters adolescent dopamine system development (2019) (21)
- Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18. (1987) (20)
- Receptor localization : ligand autoradiography (1988) (20)
- Central myelin gene expression during postnatal development in rats exposed to nicotine gestationally (2013) (19)
- Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype. (1991) (19)
- The use of ascorbate as a probe of opioid receptor structure: evidence for two independent mechanisms of receptor destruction by ascorbate. (1980) (18)
- Further pharmacological characterization of [3H]idazoxan binding sites in rat brain: evidence for predominant labeling ofα 2-adrenergic receptors (1992) (18)
- Nicotinic acetylcholine receptor subunit mRNA expression in adult and developing rat medullary catecholamine neurons (2008) (18)
- Gender difference in levels of α2-adrenoceptor mRNA in the rat tail artery (1999) (17)
- Proceedings: Assessment of the agonist and antagonist activities of narcotic analgesic drugs by means of the mouse vas deferens. (1974) (17)
- The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats (2017) (17)
- Enhanced nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from neonatal rat hypothalamus (2006) (16)
- Serotonergic mechanism underlying tranylcypromine enhancement of nicotine self‐administration (2011) (15)
- Opioid Effects on [3H]Norepinephrine Release from Dissociated Embryonic Locus Coeruleus Cell Cultures (1994) (15)
- Vaccination against nicotine does not prevent nicotine-induced changes in fetal nicotinic receptor binding and c-fos mRNA expression in rats. (2006) (15)
- Nicotine modulation of adolescent dopamine receptor signaling and hypothalamic peptide response (2014) (14)
- Age-dependent alterations in reward-seeking behavior after brief nicotine exposure (2014) (13)
- Glial Regulation of α7‐Type Nicotinic Acetylcholine Receptor Expression in Cultured Rat Cortical Neurons (1997) (12)
- Narcotic agonist and antagonist potencies of a homologous series of N‐alkyl‐norketobemidones measured by the guinea‐pig ileum and mouse vas deferens methods (1975) (12)
- Opioid Receptors and the Developing Nervous System (1993) (12)
- Nicotine-induced brain metabolism associated with anger provocation (2009) (12)
- Comparison of the receptor binding characteristics of opiate agonists interacting with mu- or kappa-receptors. (1978) (12)
- Characteristics of peptide and alkaloid opiate binding sites in brain and peripheral tissues. (1980) (11)
- Use of Organ Systems for Opioid Bioassay (1993) (11)
- Few cortical cholecystokinin immunoreactive neurons have long projections (2004) (11)
- Effect of ascorbate on the toxicity of morphine in mice (1985) (10)
- Erratum: Brain monoglyceride lipase participating in endocannabinoid inactivation (Proceedings of the National Academy of Sciences of the United States of America (August 6, 2002) 99:16 (10819-10824)) (2002) (9)
- Transient appearance of beta-endorphin immunoreactive cells within the germinal zone of neonatal rat forebrain (1991) (8)
- Differences in mechanisms underlying reinstatement of cigarette smoke extract- and nicotine-seeking behavior in rats (2019) (8)
- Gender difference in levels of alpha2-adrenoceptor mRNA in the rat tail artery. (1999) (7)
- Alpha2B adrenoceptor mRNA expression during rat brain development. (1997) (7)
- Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition. (2007) (7)
- BAM-18: Analgesia, hyperalgesia and locomotor effects (1988) (6)
- Chronic exposure to cigarette smoke extract upregulates nicotinic receptor binding in adult and adolescent rats (2020) (5)
- Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3'-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate. (2005) (5)
- Neuropathic Pain Alters Reward and Affect via Kappa Opioid Receptor (KOR) Upregulation (2016) (5)
- Opioid receptors in the accessory optic system of the rat: Effects of monocular enucleation (1990) (5)
- Glial regulation of alpha 7-type nicotinic acetylcholine receptor expression in cultured rat cortical neurons. (1997) (4)
- Neurotrophic factors in the CNS: biosynthetic processing and functional responses. (1990) (4)
- Opioid receptor changes in weaver mouse striatum (1992) (4)
- Nicotinic Receptor Regulation of Developing Catecholamine Systems (2006) (3)
- Differential behavioral and neurochemical effects of nicotine treatment in adolescent and adult rats (2008) (3)
- Assessment of the agonist and antagonist activities of narcotic analgesic drugs by means of the mouse (2006) (3)
- Combined nicotine and ethanol age-dependently alter neural and behavioral responses in male rats (2021) (3)
- The pharmacological profile of BAM 18. (1986) (2)
- LIGAND SPECIFICITY OF OPIOID BINDING SITES IN BRAIN AND PERIPHERAL TISSUES (1980) (2)
- Opiate receptor mechanisms : an in vitro analysis (1977) (2)
- Stress, Sex and Adolescent Nicotine Response (2009) (1)
- Quantitative Light Microscopic Autoradiography of α 2 -Adrenergic Radioligand Binding Sites (2000) (1)
- ASCORBATE DESTRUCTION OF OPIOID STEREOSPECIFIC BINDING; EVIDENCE FOR RECEPTOR REGULATION BY MEMBRANE LIPID (1980) (1)
- Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adolescent Rats with a Human Polymorphism (rs2304297) in the 3′-UTR of the CHRNA6 Gene (2022) (1)
- The role of the kappa‐opioid receptor on age‐specific behaviors induced from co‐administration of alcohol and nicotine (2013) (1)
- Weaning-induced changes in δ-opioid receptor subtypes: Evidence from autoradiography and in situ hybridisation (1994) (1)
- Subunit mRNA and a-Bungarotoxin Binding Sites in Developing Mouse Somatosensory Thalamocortical System (2004) (1)
- Intraventricular administration of BAM-18: antinociceptive and locomotor activity in the rat. (1986) (1)
- Inhibition of [3H]-naloxone binding by opiate agonists [proceedings]. (1977) (1)
- EFFECTOF MORPHINEON ADRENERGIC TRANSMISSIONINTHE MOUSE VAS DEFERENS.ASSESSMENTOF AGONISTAND ANTAGONISTPOTENCIESOF NARCOTICANALGESICS (1975) (0)
- MAO inhibition increases sensitivity to nicotine’s rewarding properties in male and female rats. (2006) (0)
- Age-dependent alterations in reward-seeking behavior after brief nicotine exposure (2013) (0)
- Alzheimer ' s disease Chronic nicotine administration exacerbates tau pathology in a transgenic model of (2005) (0)
- Title Multigenerational epigenetic effects of nicotine on lung function Permalink (2013) (0)
- 1040 – RATE 0F 0NSET AND OFFSET OF ACTION OF NARCOTIC ANALGESIC DRUGS IN ISOLATED PREPARATIONS (1977) (0)
- 117 Alpha2A adrenoceptor expression during neocortical development (1996) (0)
- NEW ANIMAL RESEARCH SHOWS EFFECTS OF PRENATAL DRUG EXPOSURE AND EARLY LIFE INFECTIONS ON THE BRAIN (2010) (0)
- Title Adolescent maturation of dopamine D 1 and D 2 receptor function and interactions in rodents Permalink (2016) (0)
- Impact of tobacco smoke constituents on nicotine-seeking behavior in adolescent and adult male rats (2023) (0)
- Morphine effects on tritiated thymidine incorporation into neonatal rat brain dna (1985) (0)
- SK channels modulate firing frequency, calcium influx, and stress‐induced catecholamine secretion in mice. (2007) (0)
- Neurobiology of opioids edited by O.F.X. Almeida and T.S. Shippenberg, Springer-Verlag, 1991. $149.00 (xi + 456 pages) ISBN 0 387 50835 X (1992) (0)
- Ligands de type alpha-4-beta-2 marques et procedes associes (2005) (0)
- Quantitative light microscopic autoradiography of alpha 2-adrenergic radioligand binding sites. (2000) (0)
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What Schools Are Affiliated With Frances M. Leslie?
Frances M. Leslie is affiliated with the following schools: