Frances M. Leslie

Frances M. Leslie's AcademicInfluence.com Rankings

Frances M. Leslie

Medical

#3315

World Rank

#3782

Historical Rank

Pharmacology

#410

World Rank

#463

Historical Rank

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Medical

Frances M. Leslie's Degrees

PhD Pharmacology University of California, Irvine
Bachelors Biological Sciences University of California, Irvine

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Frances M. Leslie's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Brain monoglyceride lipase participating in endocannabinoid inactivation (2002) (1301)
Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus (2002) (697)
Distribution of dynorphin and enkephalin peptides in the rat brain (1986) (519)
The dynamic effects of nicotine on the developing brain. (2009) (509)
EFFECT OF MORPHINE ON ADRENERGIC TRANSMISSION IN THE MOUSE VAS DEFERENS. ASSESSMENT OF AGONIST AND ANTAGONIST POTENCIES OF NARCOTIC ANALGESICS (1975) (391)
Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain (2001) (356)
Dependence of Olfactory Bulb Neurogenesis on Prokineticin 2 Signaling (2005) (308)
Nicotine and the adolescent brain (2015) (306)
Trophic stimulation of cultured neurons from neonatal rat brain by epidermal growth factor. (1987) (295)
Impulsive and Self-Conscious: Adolescents' Vulnerability to Advertising and Promotion (2005) (288)
Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats (2004) (279)
Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons (2002) (259)
Nicotine and brain development. (2008) (248)
Acetaldehyde Enhances Acquisition of Nicotine Self-Administration in Adolescent Rats (2005) (238)
Methods used for the study of opioid receptors. (1987) (221)
Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain. (1987) (196)
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. (2005) (189)
ASSESSMENT IN THE GUINEA‐PIG ILEUM AND MOUSE VAS DEFERENS OF BENZOMORPHANS WHICH HAVE STRONG ANTINOCICEPTIVE ACTIVITY BUT DO NOT SUBSTITUTE FOR MORPHINE IN THE DEPENDENT MONKEY (1975) (174)
Postnatal development of multiple opioid receptors in rat brain. (1987) (154)
Smoking to self-medicate attentional and emotional dysfunctions. (2007) (152)
Pharmacological evidence for alpha-2 adrenoceptor heterogeneity: differential binding properties of [3H]rauwolscine and [3H]idazoxan in rat brain. (1987) (145)
Developmental expression ofα7 neuronal nicotinic receptor messenger RNA in rat sensory cortex and thalamus (1995) (137)
Developmental regulation of nicotinic acetylcholine receptors within midbrain dopamine neurons (2007) (129)
Regulation of α7 Nicotinic Acetylcholine Receptors in the Developing Rat Somatosensory Cortex by Thalamocortical Afferents (1996) (128)
Co-expression of α7 and β2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons (2003) (126)
Codistribution of nicotinic acetylcholine receptor subunit α3 and β4 mRNAs during rat brain development (1997) (126)
Behavioral effects and in vivo degradation of intraventricularly administered dynorphin-(1-13) and D-Ala2-dynorphin-(1-11) in rats. (1980) (124)
A Critical Period for Nicotine-Induced Disruption of Synaptic Development in Rat Auditory Cortex (2000) (116)
Low dose nicotine treatment during early adolescence increases subsequent cocaine reward. (2007) (116)
Differential appearance of opiate receptor subtypes in neonatal rat brain. (1982) (115)
Expression of α 2 adrenoceptors during rat brain development—I. α 2A messenger RNA expression (1996) (104)
Ascorbate Decreases Ligand Binding to Neurotransmitter Receptors (1980) (102)
Expression of prokineticins and their receptors in the adult mouse brain (2006) (102)
Opioid activities of fragments of beta-endorphin and of its leucine65-analogue. Comparison of the binding properties of methionine- and leucine-enkephalin. (1979) (100)
Noradrenergic changes and memory loss in aged mice (1985) (100)
Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formation. (2002) (97)
Effects of morphine on DNA synthesis in neonatal rat brain. (1987) (93)
Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites. (1980) (92)
Adolescent Development of Forebrain Stimulant Responsiveness: Insights from Animal Studies (2004) (92)
Neonatal nicotine exposure impairs nicotinic enhancement of central auditory processing and auditory learning in adult rats (2006) (88)
Expression of α 2 adrenoceptors during rat brain development—II. α 2C messenger RNA expression and [3H]rauwolscine binding (1996) (86)
The alpha7 nicotinic acetylcholine receptor in neuronal plasticity. (1999) (86)
The α7 nicotinic acetylcholine receptor in neuronal plasticity (1999) (85)
Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons. (2003) (85)
Monoamine Oxidase Inhibitors Allow Locomotor and Rewarding Responses to Nicotine (2006) (85)
Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping population of neocortical neurons in vitro (1990) (84)
Dynorphin-containing pathways in the substantia nigra and ventral tegmentum: A double labeling study using combined immunofluorescence and retrograde tracing (1985) (84)
Expression of α5 nicotinic acetylcholine receptor subunit mRNA during hippocampal and cortical development (2005) (83)
The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt (2012) (83)
Neonatal treatment with 192 IgG-saporin produces long-term forebrain cholinergic deficits and reduces dendritic branching and spine density of neocortical pyramidal neurons. (1998) (82)
AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats (2012) (76)
Nicotinic Receptors in Addiction Pathways (2013) (72)
Nicotine Alters Limbic Function in Adolescent Rat by a 5-HT1A Receptor Mechanism (2011) (71)
Sex‐dependent effects of nicotine on the developing brain (2017) (71)
Prenatal nicotine exposure changes natural and drug‐induced reinforcement in adolescent male rats (2008) (70)
Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain (2019) (69)
Gender Specific Effect of Neonatal Handling on Stress Reactivity of Adolescent Rats (2003) (69)
Acetaldehyde, a Major Constituent of Tobacco Smoke, Enhances Behavioral, Endocrine, and Neuronal Responses to Nicotine in Adolescent and Adult Rats (2007) (65)
COMPARISON OF THE RECEPTOR BINDING CHARACTERISTICS OF OPIATE AGONISTS INTERACTING WITH μ‐ OR K‐RECEPTORS (1978) (65)
Highly sensitive radioactive in situ hybridization using full length hydrolyzed riboprobes to detect alpha 2 adrenoceptor subtype mRNAs in adult and developing rat brain. (1999) (65)
Tobacco use across the formative years: a road map to developmental vulnerabilities. (2003) (64)
Behavioral and receptor binding analysis of the α2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-YL amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an α2-adrenoceptor subtype (1991) (64)
Comparison of the Reinforcing Properties of Nicotine and Cigarette Smoke Extract in Rats (2014) (64)
Multigenerational epigenetic effects of nicotine on lung function (2013) (64)
Tranylcypromine enhancement of nicotine self-administration (2007) (64)
Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse (2017) (63)
The urotensin II receptor is expressed in the cholinergic mesopontine tegmentum of the rat (2001) (63)
Postnatal development of opioid systems in rat brain (1985) (63)
Ascorbate destruction of opiate stereospecific binding in guinea pig brain homogenate. (1979) (62)
Both the sigma receptor-specific ligand (+)3-PPP and the PCP receptor-specific ligand TCP act in the mouse vas deferens via augmentation of electrically evoked norepinephrine release. (1987) (60)
Adolescent Maturation of Cocaine-Sensitive Neural Mechanisms (2007) (59)
Nicotine exposure during a postnatal critical period alters NR2A and NR2B mRNA expression in rat auditory forebrain. (2002) (56)
α2B Adrenoceptor mRNA expression during rat brain development (1997) (53)
Nicotine‐Stimulated Release of [3H]Norepinephrine from Fetal Rat Locus Coeruleus Cells in Culture (1998) (52)
Localization of α7 nicotinic receptor subunit mRNA and α‐bungarotoxin binding sites in developing mouse somatosensory thalamocortical system (1995) (52)
Regulation of Homer and group I metabotropic glutamate receptors by nicotine (2005) (50)
Degradation of dynorphin-(1–13) by membrane-bound rat brain enzymes (1982) (48)
Negative Allosteric Modulation of Nicotinic Acetylcholine Receptors Blocks Nicotine Self-Administration in Rats (2007) (47)
Expression of alpha2A adrenoceptors during rat neocortical development. (1999) (46)
Cholinergic binding sites in rat brain: Analysis by age and cognitive status (1995) (45)
Locomotor and stress responses to nicotine differ in adolescent and adult rats (2010) (45)
Rat ventral midbrain dopamine neurons express the orphanin FQ/nociceptin receptor ORL-1 (2002) (44)
Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures (2002) (43)
Unique, long-term effects of nicotine on adolescent brain (2020) (42)
Neurochemical properties of the prolactin releasing peptide (PrRP) receptor expressing neurons: evidence for a role of PrRP as a regulator of stress and nociception (2002) (42)
Developmental regulation of nicotinic acetylcholine receptor‐mediated [3H]norepinephrine release from rat cerebellum (2003) (41)
Postnatal Development of NR2A and NR2B mRNA Expression in Rat Auditory Cortex and Thalamus (2002) (39)
Opioid receptor and peptide mRNA expression in proliferative zones of fetal rat central nervous system. (1998) (39)
20 – Neurotransmitters as Neurotrophic Factors (1993) (38)
Nicotine modulation of stress‐related peptide neurons (2006) (37)
Age-dependent effects of low-dose nicotine treatment on cocaine-induced behavioral plasticity in rats (2009) (37)
Expression of alpha 2 adrenoceptors during rat brain development--I. Alpha 2A messenger RNA expression. (1997) (37)
Development of delta-opioid receptor subtypes and the regulatory role of weaning: radioligand binding, autoradiography and in situ hybridization studies. (1995) (36)
Glial mechanisms underlying substance use disorders (2018) (36)
Gestational nicotine treatment modulates cell death/survival-related pathways in the brains of adolescent female rats. (2011) (35)
Cigarette Smoke Extract: A Preclinical Model of Tobacco Dependence (2016) (34)
Gestational nicotine exposure modifies myelin gene expression in the brains of adolescent rats with sex differences (2013) (34)
Adolescent Maturation of Dopamine D1 and D2 Receptor Function and Interactions in Rodents (2016) (34)
kappa-Opioid inhibition of [3H]dopamine release from rat ventral mesencephalic dissociated cell cultures. (1992) (34)
Nicotinic acetylcholine receptor-mediated release of [3H]norepinephrine from developing and adult rat hippocampus: direct and indirect mechanisms (2002) (34)
Microglial activation increases cocaine self-administration following adolescent nicotine exposure (2020) (33)
Reinforcing and neural activating effects of norharmane, a non-nicotine tobacco constituent, alone and in combination with nicotine (2014) (33)
Rates of onset and offset of action of narcotic analgesics in isolated preparations. (1975) (32)
Long-term changes in striatal opioid systems after 6-hydroxydopamine lesion of rat substantia nigra (1993) (32)
Effect of acetylcholinesterase inhibitors on the binding of nicotinic α4β2 receptor PET radiotracer, 18F‐nifene: A measure of acetylcholine competition (2007) (29)
Age influences the effects of nicotine and monoamine oxidase inhibition on mood-related behaviors in rats (2010) (28)
Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat (2007) (27)
Age, sex and early environment contribute to individual differences in nicotine/acetaldehyde-induced behavioral and endocrine responses in rats (2007) (27)
Comparison of binding of [3H]-methionine-enkephalin, [3H]-naltrexone and [3H]-dihydromorphine in the mouse vas deferens and the myenteric plexus and brain of the ginea pig. (1979) (26)
Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats. (2011) (26)
Expression of opioid peptides and receptors in striatum and substantia nigra during rat brain development (2003) (25)
Gestational exposure to nicotine and monoamine oxidase inhibitors influences cocaine-induced locomotion in adolescent rats (2007) (25)
Calcium Regulation of Agonist Binding to α7‐Type Nicotinic Acetylcholine Receptors in Adult and Fetal Rat Hippocampus (1998) (25)
Nicotine Increases Alcohol Intake in Adolescent Male Rats (2017) (25)
Synthesis and Evaluation of Nicotine 42 Receptor Radioligand, 5-(3- 18 F-Fluoropropyl)-3- (2-(S)-Pyrrolidinylmethoxy)Pyridine, in Rodents and PET in Nonhuman Primate (2005) (25)
N-[3H]methylscopolamine labeling of non-M1, non-M2 muscarinic receptor binding sites in rat brain. (1991) (23)
Self-administration of nicotine and cigarette smoke extract in adolescent and adult rats (2016) (23)
Gestational nicotine-induced changes in adolescent neuronal activity (2006) (23)
Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse (2019) (23)
Expression of alpha 2 adrenoceptors during rat brain development--II. Alpha 2C messenger RNA expression and [3H]rauwolscine binding. (1997) (23)
The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition (2011) (22)
Prenatal nicotine sex-dependently alters adolescent dopamine system development (2019) (21)
Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18. (1987) (20)
Receptor localization : ligand autoradiography (1988) (20)
Central myelin gene expression during postnatal development in rats exposed to nicotine gestationally (2013) (19)
Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype. (1991) (19)
The use of ascorbate as a probe of opioid receptor structure: evidence for two independent mechanisms of receptor destruction by ascorbate. (1980) (18)
Further pharmacological characterization of [3H]idazoxan binding sites in rat brain: evidence for predominant labeling ofα 2-adrenergic receptors (1992) (18)
Nicotinic acetylcholine receptor subunit mRNA expression in adult and developing rat medullary catecholamine neurons (2008) (18)
Gender difference in levels of α2-adrenoceptor mRNA in the rat tail artery (1999) (17)
Proceedings: Assessment of the agonist and antagonist activities of narcotic analgesic drugs by means of the mouse vas deferens. (1974) (17)
The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats (2017) (17)
Enhanced nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from neonatal rat hypothalamus (2006) (16)
Serotonergic mechanism underlying tranylcypromine enhancement of nicotine self‐administration (2011) (15)
Opioid Effects on [3H]Norepinephrine Release from Dissociated Embryonic Locus Coeruleus Cell Cultures (1994) (15)
Vaccination against nicotine does not prevent nicotine-induced changes in fetal nicotinic receptor binding and c-fos mRNA expression in rats. (2006) (15)
Nicotine modulation of adolescent dopamine receptor signaling and hypothalamic peptide response (2014) (14)
Age-dependent alterations in reward-seeking behavior after brief nicotine exposure (2014) (13)
Glial Regulation of α7‐Type Nicotinic Acetylcholine Receptor Expression in Cultured Rat Cortical Neurons (1997) (12)
Narcotic agonist and antagonist potencies of a homologous series of N‐alkyl‐norketobemidones measured by the guinea‐pig ileum and mouse vas deferens methods (1975) (12)
Opioid Receptors and the Developing Nervous System (1993) (12)
Nicotine-induced brain metabolism associated with anger provocation (2009) (12)
Comparison of the receptor binding characteristics of opiate agonists interacting with mu- or kappa-receptors. (1978) (12)
Characteristics of peptide and alkaloid opiate binding sites in brain and peripheral tissues. (1980) (11)
Use of Organ Systems for Opioid Bioassay (1993) (11)
Few cortical cholecystokinin immunoreactive neurons have long projections (2004) (11)
Effect of ascorbate on the toxicity of morphine in mice (1985) (10)
Erratum: Brain monoglyceride lipase participating in endocannabinoid inactivation (Proceedings of the National Academy of Sciences of the United States of America (August 6, 2002) 99:16 (10819-10824)) (2002) (9)
Transient appearance of beta-endorphin immunoreactive cells within the germinal zone of neonatal rat forebrain (1991) (8)
Differences in mechanisms underlying reinstatement of cigarette smoke extract- and nicotine-seeking behavior in rats (2019) (8)
Gender difference in levels of alpha2-adrenoceptor mRNA in the rat tail artery. (1999) (7)
Alpha2B adrenoceptor mRNA expression during rat brain development. (1997) (7)
Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition. (2007) (7)
BAM-18: Analgesia, hyperalgesia and locomotor effects (1988) (6)
Chronic exposure to cigarette smoke extract upregulates nicotinic receptor binding in adult and adolescent rats (2020) (5)
Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3'-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate. (2005) (5)
Neuropathic Pain Alters Reward and Affect via Kappa Opioid Receptor (KOR) Upregulation (2016) (5)
Opioid receptors in the accessory optic system of the rat: Effects of monocular enucleation (1990) (5)
Glial regulation of alpha 7-type nicotinic acetylcholine receptor expression in cultured rat cortical neurons. (1997) (4)
Neurotrophic factors in the CNS: biosynthetic processing and functional responses. (1990) (4)
Opioid receptor changes in weaver mouse striatum (1992) (4)
Nicotinic Receptor Regulation of Developing Catecholamine Systems (2006) (3)
Differential behavioral and neurochemical effects of nicotine treatment in adolescent and adult rats (2008) (3)
Assessment of the agonist and antagonist activities of narcotic analgesic drugs by means of the mouse (2006) (3)
Combined nicotine and ethanol age-dependently alter neural and behavioral responses in male rats (2021) (3)
The pharmacological profile of BAM 18. (1986) (2)
LIGAND SPECIFICITY OF OPIOID BINDING SITES IN BRAIN AND PERIPHERAL TISSUES (1980) (2)
Opiate receptor mechanisms : an in vitro analysis (1977) (2)
Stress, Sex and Adolescent Nicotine Response (2009) (1)
Quantitative Light Microscopic Autoradiography of α 2 -Adrenergic Radioligand Binding Sites (2000) (1)
ASCORBATE DESTRUCTION OF OPIOID STEREOSPECIFIC BINDING; EVIDENCE FOR RECEPTOR REGULATION BY MEMBRANE LIPID (1980) (1)
Sex- and Genotype-Dependent Nicotine-Induced Behaviors in Adolescent Rats with a Human Polymorphism (rs2304297) in the 3′-UTR of the CHRNA6 Gene (2022) (1)
The role of the kappa‐opioid receptor on age‐specific behaviors induced from co‐administration of alcohol and nicotine (2013) (1)
Weaning-induced changes in δ-opioid receptor subtypes: Evidence from autoradiography and in situ hybridisation (1994) (1)
Subunit mRNA and a-Bungarotoxin Binding Sites in Developing Mouse Somatosensory Thalamocortical System (2004) (1)
Intraventricular administration of BAM-18: antinociceptive and locomotor activity in the rat. (1986) (1)
Inhibition of [3H]-naloxone binding by opiate agonists [proceedings]. (1977) (1)
EFFECTOF MORPHINEON ADRENERGIC TRANSMISSIONINTHE MOUSE VAS DEFERENS.ASSESSMENTOF AGONISTAND ANTAGONISTPOTENCIESOF NARCOTICANALGESICS (1975) (0)
MAO inhibition increases sensitivity to nicotine’s rewarding properties in male and female rats. (2006) (0)
Age-dependent alterations in reward-seeking behavior after brief nicotine exposure (2013) (0)
Alzheimer ' s disease Chronic nicotine administration exacerbates tau pathology in a transgenic model of (2005) (0)
Title Multigenerational epigenetic effects of nicotine on lung function Permalink (2013) (0)
1040 – RATE 0F 0NSET AND OFFSET OF ACTION OF NARCOTIC ANALGESIC DRUGS IN ISOLATED PREPARATIONS (1977) (0)
117 Alpha2A adrenoceptor expression during neocortical development (1996) (0)
NEW ANIMAL RESEARCH SHOWS EFFECTS OF PRENATAL DRUG EXPOSURE AND EARLY LIFE INFECTIONS ON THE BRAIN (2010) (0)
Title Adolescent maturation of dopamine D 1 and D 2 receptor function and interactions in rodents Permalink (2016) (0)
Impact of tobacco smoke constituents on nicotine-seeking behavior in adolescent and adult male rats (2023) (0)
Morphine effects on tritiated thymidine incorporation into neonatal rat brain dna (1985) (0)
SK channels modulate firing frequency, calcium influx, and stress‐induced catecholamine secretion in mice. (2007) (0)
Neurobiology of opioids edited by O.F.X. Almeida and T.S. Shippenberg, Springer-Verlag, 1991. $149.00 (xi + 456 pages) ISBN 0 387 50835 X (1992) (0)
Ligands de type alpha-4-beta-2 marques et procedes associes (2005) (0)
Quantitative light microscopic autoradiography of alpha 2-adrenergic radioligand binding sites. (2000) (0)

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What Schools Are Affiliated With Frances M. Leslie?

Frances M. Leslie is affiliated with the following schools:

University of California, Irvine