Francesco Lo-Coco
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Philosophy
Why Is Francesco Lo-Coco Influential?
(Suggest an Edit or Addition)Francesco Lo-Coco's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells (2001) (1785)
- Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. (1993) (690)
- Definition of relapse risk and role of nonanthracycline drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups. (2000) (616)
- Acute promyelocytic leukemia: from genetics to treatment. (1994) (537)
- p53 mutations are associated with histologic transformation of follicular lymphoma. (1993) (389)
- Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. (1994) (378)
- Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action "Mole (2000) (333)
- Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. (2005) (319)
- Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. (1994) (303)
- Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. (1992) (281)
- AIDA (all-trans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia: a Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) pilot study. (1996) (265)
- Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus. (1991) (260)
- Therapy of molecular relapse in acute promyelocytic leukemia. (1999) (238)
- Molecular remission in PML/RAR alpha-positive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy. Gruppo Italiano-Malattie Ematologiche Maligne dell'Adulto and Associazione Italiana di Ematologia ed Oncologia Pediatrica Cooperative Groups. (1997) (224)
- Genetic diagnosis and molecular monitoring in the management of acute promyelocytic leukemia. (1999) (218)
- Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele. (2009) (207)
- Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias (1990) (205)
- Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia. (2006) (195)
- Molecular monitoring of the myl/retinoic acid receptor-alpha fusion gene in acute promyelocytic leukemia by polymerase chain reaction. (1992) (191)
- GIMEMA-AIEOPAIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children. (2005) (191)
- Immunophenotype of adult and childhood acute promyelocytic leukaemia: correlation with morphology, type of PML gene breakpoint and clinical outcome. A cooperative Italian study on 196 cases (1998) (187)
- Toward optimization of postremission therapy for residual disease-positive patients with acute myeloid leukemia. (2008) (161)
- CD56 expression is an indicator of poor clinical outcome in patients with acute promyelocytic leukemia treated with simultaneous all-trans-retinoic acid and chemotherapy. (2000) (157)
- Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia. (1992) (142)
- Extramedullary involvement at relapse in acute promyelocytic leukemia patients treated or not with all-trans retinoic acid: a report by the Gruppo Italiano Malattie Ematologiche dell'Adulto. (2001) (139)
- Immunocytochemical diagnosis of acute promyelocytic leukemia (M3) with the monoclonal antibody PG-M3 (anti-PML). (1997) (131)
- ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy. (1993) (129)
- TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL. (2005) (125)
- Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features. (1995) (124)
- Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease. (1996) (123)
- Therapy-related myelodysplastic syndrome-acute myelogenous leukemia in patients treated for acute promyelocytic leukemia: an emerging problem. (2002) (123)
- Cytogenetic and molecular diagnostic characterization combined to postconsolidation minimal residual disease assessment by flow cytometry improves risk stratification in adult acute myeloid leukemia. (2010) (122)
- Genetic characterization of HHV‐8/KSHV–positive primary effusion lymphoma reveals frequent mutations of BCL6: Implications for disease pathogenesis and histogenesis (1999) (113)
- RAR-alpha gene rearrangements as a genetic marker for diagnosis and monitoring in acute promyelocytic leukemia. (1991) (110)
- Clinicobiological features and outcome of acute promyelocytic leukemia occurring as a second tumor: the GIMEMA experience. (2002) (109)
- GIMEMA AML1310 TRIAL OF RISK-ADAPTED, MRD-DIRECTED THERAPY FOR YOUNG ADULTS WITH NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA. (2019) (106)
- Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias. (1997) (105)
- Extranodal lymphomas associated with hepatitis C virus infection. (1998) (104)
- Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase. (1996) (102)
- A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells. (1995) (101)
- Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements (2003) (96)
- Early detection of relapse by prospective reverse transcriptase-polymerase chain reaction analysis of the PML/RARalpha fusion gene in patients with acute promyelocytic leukemia enrolled in the GIMEMA-AIEOP multicenter "AIDA" trial. GIMEMA-AIEOP Multicenter "AIDA" Trial. (1998) (95)
- Increase in platelet count in older, poor‐risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all‐trans retinoic acid (2005) (93)
- Second primary cancer following Hodgkin's disease: updated results of an Italian multicentric study. (1991) (91)
- Prognostic relevance of ALL-1 gene rearrangement in infant acute leukemias. (1995) (89)
- Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma: association with diffuse large-cell subtype. (1994) (88)
- Molecular evaluation of response to all-trans-retinoic acid therapy in patients with acute promyelocytic leukemia. (1991) (79)
- The Simpler the Better: Oral Arsenic for Acute Promyelocytic Leukemia. (2019) (78)
- Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation. (1992) (75)
- Arsenic trioxide in the treatment of acute promyelocytic leukemia. A review of current evidence. (2005) (74)
- Acute promyelocytic leukemia: clinical and morphologic features and prognostic factors. (2001) (72)
- Autologous bone marrow transplantation for acute promyelocytic leukemia in second remission: prognostic relevance of pretransplant minimal residual disease assessment by reverse-transcription polymerase chain reaction of the PML/RAR alpha fusion gene. (1997) (69)
- Identification of genetic lesions associated with diffuse large-cell lymphoma. (1994) (68)
- The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias. (1997) (66)
- Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies. (2002) (66)
- Primary effusion Burkitt's lymphoma with t(8;22) in a patient with hepatitis C virus-related cirrhosis. (1997) (60)
- Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men. (1999) (59)
- Interferon therapy for Ph1 positive CML patients relapsing after T cell-depleted allogeneic bone marrow transplantation. (1990) (55)
- The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP‐70‐negative chronic lymphocytic leukemia (2005) (52)
- Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells. (1997) (49)
- High-mobility group A1 proteins are overexpressed in human leukaemias. (2003) (48)
- Clinico-biological features and outcome of acute promyelocytic leukemia patients with persistent polymerase chain reaction-detectable disease after the AIDA front-line induction and consolidation therapy. (2004) (46)
- Clinical relevance of residual disease monitoring by polymerase chain reaction in patients with ALL‐1/AF‐4 positive‐acute lymphoblastic leukaemia (1996) (46)
- Thrombo-hemorrhagic deaths in acute promyelocytic leukemia. (2014) (42)
- Absence of reverse transcription-polymerase chain reaction detectable residual disease in patients with acute promyelocytic leukemia in long-term remission. (1993) (42)
- Risk-adapted treatment of acute promyelocytic leukemia: results from the International Consortium for Childhood APL. (2018) (41)
- The PML/RAR alpha fusion gene in the diagnosis and monitoring of acute promyelocytic leukemia. (1995) (40)
- Improved rapid detection of the PML/RARalpha fusion gene in acute promyelocytic leukemia. (1996) (39)
- Therapy of acute myeloid leukemia: towards a patient-oriented, risk-adapted approach. (1998) (39)
- Variability in the levels of PML-RAR alpha fusion transcripts detected by the laboratories participating in an external quality control program using several reverse transcription polymerase chain reaction protocols. (2001) (39)
- Frequency of RAS and p53 mutations in acute promyelocytic leukemias. (1993) (39)
- Adult Philadelphia-chromosome-positive acute lymphoblastic leukemia: experience of treatments during a ten-year period. (1994) (39)
- Choice of chemotherapy in induction, consolidation and maintenance in acute promyelocytic leukaemia. (2003) (37)
- Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR. (1994) (37)
- Human herpesvirus 8-associated primary effusion lymphoma in HIV--patients: a clinicopidemiologic variant resembling classic Kaposi's sarcoma. (2002) (36)
- Identification of DNA rearrangements at the retinoic acid receptor-alpha (RAR-alpha) locus in all patients with acute promyelocytic leukemia (APL) and mapping of APL breakpoints within the RAR-alpha second intron. Italian Cooperative Study Group "GIMEMA". (1992) (35)
- Southern blot analysis of ALL-1 rearrangements at chromosome 11q23 in acute leukemia. (1993) (34)
- Human herpesvirus-8 in lymphomatous and nonlymphomatous body cavity effusions developing in Kaposi's sarcoma and multicentric Castleman's disease. (1999) (33)
- Treatment of acute promyelocytic leukemia with gemtuzumab ozogamicin. (2006) (32)
- Acute Promyelocytic Leukemia (APL): Comparison Between Children and Adults (2014) (32)
- BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma. (1995) (30)
- Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines (2015) (29)
- Apoptosis and immaturity in acute myeloid leukemia (2005) (29)
- The role of all-trans-retinoic acid (ATRA) treatment in newly-diagnosed acute promyelocytic leukemia patients aged > 60 years. (1997) (28)
- Primary effusion lymphoma containing human herpesvirus 8 DNA in two AIDS patients with Kaposi's sarcoma. (1998) (27)
- The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts. (1998) (27)
- BCL-6 and the molecular pathogenesis of B-cell lymphoma. (1994) (25)
- Immunophenotype of acute lymphoblastic leukemia cells: the experience of the Italian Cooperative Group (Gimema). (1993) (25)
- Promyelocytic Sarcoma of the Spine: A Case Report and Review of the Literature (2010) (25)
- BCL-6 in diffuse large-cell lymphomas. (1996) (23)
- p53 gene inactivation in acute lymphoblastic leukemia of B cell lineage associates with chromosomal breakpoints at 11q23 and 8q24. (1995) (21)
- Distribution of TP53 mutations among acute leukemias with MLL rearrangements (1996) (21)
- Advances in the understanding and management of acute promyelocytic leukemia. (2002) (21)
- Current treatment of acute promyelocytic leukemia. (2007) (19)
- Prolonged suppression of myeloid progenitor cell numbers after stopping interferon treatment for CML may necessitate delay in harvesting marrow cells for autografting. (1990) (19)
- Autologous bone marrow or peripheral blood stem cell transplantation for patients with chronic myelogenous leukaemia in chronic phase. (1989) (18)
- Arsenic trioxide in the treatment of advanced acute promyelocytic leukemia. (2004) (18)
- Combining gene mutation with gene expression analysis improves outcomes prediction in acute promyelocytic leukemia. (2019) (18)
- Immune-deficiency in Hodgkin's disease (HD): a study of patients and healthy relatives in families with multiple cases. (1988) (18)
- Genetic lesions associated with blastic transformation of polycythemia vera and essential thrombocythemia (1997) (17)
- Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells (2015) (17)
- AIDA treatment for high-risk acute promyelocytic leukemia in a pregnant woman at 21 weeks of gestation. (2002) (17)
- CD5 negative lymphocytosis mimicking typical B-chronic lymphocytic leukaemia. Description of 26 cases. (1993) (17)
- Therapy-induced Ph1 suppression in chronic myeloid leukemia: molecular and cytogenetic studies in patients treated with alpha-2b IFN, high-dose chemotherapy and autologous stem cell infusion. (1990) (17)
- A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review (2019) (16)
- Expression of GATA-1 mRNA in human myeloid leukemic cells. (1994) (16)
- Occurrence of a Ki-1-positive anaplastic large-cell lymphoma in a patient with Ph' positive chronic myelogenous leukemia successfully treated by alpha-interferon. (1993) (16)
- Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD+ AML. (2019) (16)
- Rearrangements of the RAR-alpha gene in acute promyelocytic leukaemia: correlations with morphology and immunophenotype. (1991) (15)
- The genotype nucleophosmin mutated and FLT3‐ITD negative is characterized by high bax/bcl‐2 ratio and favourable outcome in acute myeloid leukaemia (2010) (15)
- Variant t(1;15;17)(q23;q22;q23) in a case of acute promyelocytic leukemia. (1996) (15)
- Alterations of the BCL-6 gene in diffuse large-cell lymphoma. (1995) (15)
- Standard practice and controversial issues in front-line therapy of acute promyelocytic leukemia. (2005) (14)
- Multigenetic lesions in infant acute leukaemias: correlations with ALL‐1 gene status (1997) (14)
- Acute leukemia presenting a variant Ph chromosome with p190 expression, dup 3q and -7, developed after malignant lymphoma treated with alkylating agents and topoisomerase II inhibitors. (1995) (13)
- Polyclonal hematopoietic reconstitution in leukemia patients at remission after suppression of specific gene rearrangements. (1993) (13)
- Molecular monitoring of hematologic malignancies: current and future issues. (2002) (13)
- ”Composite” lymphoma, lymphoplasmacytoid and diffuse large B-cell lymphoma of the spleen: molecular-genetic evidence of a common clonal origin (1999) (13)
- Validation of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 Summary Score in Patients With Hematologic Malignancies. (2019) (12)
- Health-related quality of life, symptom burden, and comorbidity in long-term survivors of acute promyelocytic leukemia (2018) (12)
- Molecular characterization of Ph' + hybrid acute leukemia. (1989) (11)
- Analysis of the BCL‐6 gene configuration in diffuse B‐cell non‐Hodgkin's lymphomas and Hodgkin's disease (1995) (10)
- FLT3 inhibition as tailored therapy for acute myeloid leukemia. (2003) (10)
- Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T cell features. (1989) (10)
- Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR. (1994) (9)
- Molecular biology to check patients treated for CML. (1989) (9)
- Diagnosis, front line treatment and molecular monitoring of acute promyelocytic leukaemia. (1999) (9)
- Clinical relevance of the PML/RAR-a gene rearrangement in acute promyelocytic leukaemia. (1994) (9)
- Validation of an interphase fluorescence in situ hybridization approach for the detection of MLL gene rearrangements and of the MLL/AF9 fusion in acute myeloid leukemia. (2006) (8)
- Myeloperoxidase gene expression in non-infant pro-B acute lymphoblastic leukaemia with or without ALL1/AF4 transcript. (2000) (8)
- All‐trans retinoic acid (ATRA) in non‐promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low‐dose Ara‐C in three elderly patients with NPM1‐mutated AML unfit for intensive chemotherapy and review of the literature (2016) (7)
- Identical utilization of T-cell receptor gene regions in B-lymphoid blast crisis of chronic myeloid leukemia and B-precursor acute lymphoblastic leukemia. (1991) (7)
- Immunoglobulin heavy chain and T-cell receptor beta chain gene rearrangements in acute non lymphoid leukemia. (1990) (6)
- Very late relapse in a patient with acute promyelocytic leukemia (APL) rescued with a chemotherapy-free protocol (2017) (6)
- Hybrid phenotypes and lineage promiscuity in acute leukemia. (1991) (6)
- Kaposi’s sarcoma following malignant mesothelioma (1999) (6)
- Long-term remission of T-lymphoid extramedullary blast crisis of chronic myelogenous leukemia following allogeneic bone marrow transplantation. (1990) (5)
- Management of chronic myeloid leukemia in chronic phase with autologous stem cell transplantation and alpha-2 interferon: cytogenetic and clinical results. (1993) (5)
- Mutational profile and haematological response to iron chelation in myelodysplastic syndromes (MDS) (2018) (4)
- Absence of HHV-8 DNA sequences in malignant mesothelioma. (1998) (4)
- Pregnancy in acute promyelocytic leukaemia after front‐line therapy with arsenic trioxide and all‐trans retinoic acid (2014) (4)
- Interferon therapy for Ph1-positive chronic myelogenous leukaemia patients relapsing after T-cell depleted allogeneic bone marrow transplantation. (1991) (4)
- MLL tandem duplication in two cases of acute myelocytic leukemia with unbalanced translocations: der(16)t(11;16)(q23;p13) and der(18)t(11;18)(q22;p11.2). (2003) (4)
- Herpesvirus 8-negative primary effusion lymphoma associated with hepatitis C virus. (2000) (3)
- Molecular diagnosis of Philadelphia chromosome-positive chronic myeloid leukemia. (1991) (3)
- Repeated PCR in CML during IFN-alpha therapy. (1994) (3)
- Single or multistep origin of hemopoietic tumors: the contribution of clonality studies. (1995) (3)
- Simultaneous occurrence of BCR/ABL1 and RUNX1/RUNX1T1 in a case of therapy-related acute myeloid leukemia. (2009) (2)
- Clinical usefulness of arsenic trioxide in the treatment of acute promyelocytic leukemia. (2002) (2)
- PCR-detectable transcripts in long-term remission of P190(BCR/ABL)-positive acute lymphoblastic leukemia. (2000) (2)
- On the differentiative mode of action of All-trans retinoic acid in acute promyelocytic leukemia. (1995) (1)
- Patient‐reported outcomes in acute leukemia: a roadmap for future research (2014) (1)
- Terminal deoxynucleotidil transferase (TdT) activity in human leukemia. Quantitative evaluation with enzymatic immunoassay (EIA). (1986) (1)
- A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review (2019) (0)
- Molecular genetics of the t(15;17) translocation in acute promyelocytic leukemia. (1993) (0)
- Clonality studies in CML patients treated by IFN and/or autologous bone marrow transplantation. (1994) (0)
- Development and overcoming of ATRA resistance in acute promyelocytic leukemia. (1999) (0)
- CALLA-negative, TdT- and CD7-positive acute lymphoblastic leukemia: a phenotype associated with poor prognosis. (1987) (0)
- Additive effects in the induction of apoptosis in leukemic cells by WT1 and BCR-ABL specific siRNA. (2005) (0)
- Myeloperoxidase gene expression in non‐infant pro‐B acute lymphoblastic leukaemia with or without ALL1/AF4 transcript (2000) (0)
- Cost of Treating Acute Promyelocytic Leukemia (APL) Patients in Italy. (2014) (0)
- Guidelines in hematology. (2002) (0)
- Polyclonal hemopoiesis in leukemia patients following molecularly documented remission. (1994) (0)
- Ontogeny, gene rearrangements and immunophenotype of acute leukaemias. (1989) (0)
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What Schools Are Affiliated With Francesco Lo-Coco?
Francesco Lo-Coco is affiliated with the following schools: