Francis C. Colpaert
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(Suggest an Edit or Addition)Francis C. Colpaert's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Noradrenergic mechanisms in neurodegenerative diseases: a theory (2004) (368)
- Evidence that adjuvant arthritis in the rat is associated with chronic pain (1987) (213)
- Effects of locus coeruleus lesions on parkinsonian signs, striatal dopamine and substantia nigra cell loss after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in monkeys: A possible role for the locus coeruleus in the progression of Parkinson's disease (1991) (205)
- Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects. (1990) (204)
- Stimulus properties of drugs : ten years of progress (1978) (179)
- Discriminative stimulus properties of narcotic analgesic drugs (1978) (172)
- A drug discrimination analysis of lysergic acid diethylamide (LSD): in vivo agonist and antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, a LSD-antagonist. (1982) (171)
- PPARα and PPARδ activators inhibit cytokine-induced nuclear translocation of NF-κB and expression of VCAM-1 in EAhy926 endothelial cells (2002) (169)
- Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites. (1990) (168)
- Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat (1987) (167)
- Noradrenaline provides long‐term protection to dopaminergic neurons by reducing oxidative stress (2001) (143)
- Drug Discrimination in Neurobiology (1998) (141)
- Discriminative stimulus properties of cocaine: Neuropharmacological characteristics as derived from stimulus generalization experiments (1979) (139)
- Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid. (1998) (138)
- Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia (2002) (129)
- Effects of locus coeruleus lesions on the release of endogenous dopamine in the rat nucleus accumbens and caudate nucleus as determined by intracerebral microdialysis (1990) (127)
- Apomorphine: chemistry, pharmacology, biochemistry. (1976) (123)
- Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats (2001) (116)
- Opiate States of Memory: Receptor Mechanisms (1999) (116)
- The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: Antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist (1983) (115)
- Discriminative stimulus properties of benzodiazepines, barbiturates and pharmacologically related drugs; relation to some intrinsic and anticonvulsant effects. (1976) (115)
- Discriminative stimulus properties of cocaine and d-amphetamine, and antagonism by haloperidol: A comparative study (1978) (110)
- System theory of pain and of opiate analgesia: no tolerance to opiates. (1996) (109)
- Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid (1998) (108)
- Transduction Mechanisms of Drug Stimuli (1988) (105)
- The phencyclidine (PCP) analog N-[1-(2-benzo(B)thiophenyl) cyclohexyl]piperidine shares cocaine-like but not other characteristic behavioral effects with PCP, ketamine and MK-801. (1989) (100)
- Self-administration of the analgesic suprofen in arthritic rats: evidence of Mycobacterium butyricum-induced arthritis as an experimental model of chronic pain. (1980) (100)
- The Alpha2-Adrenoceptor Antagonist Dexefaroxan Enhances Hippocampal Neurogenesis by Increasing the Survival and Differentiation of New Granule Cells (2006) (98)
- Noradrenaline depletion exacerbates MPTP-induced striatal dopamine loss in mice. (1993) (98)
- Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts. (1999) (92)
- Suppression of nigrostriatal and mesolimbic dopamine release in vivo following noradrenaline depletion by DSP-4: a microdialysis study. (1992) (92)
- Investigations on drug produced and subjectively experienced discriminative stimuli. I. The fentanyl cue, a tool to investigate subjectively experience narcotic drug actions. (1975) (91)
- How Efficacious are 5-HT1B/D Receptor Ligands: an Answer from GTPγS Binding Studies with Stably Transfected C6-glial Cell Lines (1997) (91)
- 5-HT(1A) receptor activation: new molecular and neuroadaptive mechanisms of pain relief. (2006) (88)
- NMDA antagonists make learning and recall state-dependent. (1992) (87)
- 5-HT1A receptor activation and anti-cataleptic effects: high-efficacy agonists maximally inhibit haloperidol-induced catalepsy. (2002) (86)
- Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice (1996) (86)
- Factors regulating drug cue sensitivity: limits of discriminability and the role of a progressively decreasing training dose in fentanyl-saline discrimination. (1980) (85)
- F15599, a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity. (2010) (84)
- Activation of the mitogen-activated protein kinase (ERK(1/2)) signaling pathway by cyclic AMP potentiates the neuroprotective effect of the neurotransmitter noradrenaline on dopaminergic neurons. (2002) (81)
- PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells. (2002) (76)
- Recall rendered dependent on an opiate state. (1999) (75)
- F15599, a preferential post-synaptic 5-HT1A receptor agonist: Activity in models of cognition in comparison with reference 5-HT1A receptor agonists (2010) (75)
- Effect of intrastriatal 6-OHDA lesion on dopaminergic innervation of the rat cortex and globus pallidus (2005) (74)
- Discriminative stimulus properties of fentanyl and morphine: Tolerance and dependence (1976) (74)
- Stimulated [35S]GTPγS binding by 5-HT1A receptor agonists in recombinant cell lines Modulation of apparent efficacy by G-protein activation state (1997) (74)
- The effects of prior fentanyl administration and of pain on fentanyl analgesia: tolerance to and enhancement of narcotic analgesia. (1980) (73)
- Regulation of metallothionein-III (GIF) mRNA in the brain of patients with Alzheimer disease is not impaired. (1997) (73)
- Factors regulating drug cue sensitivity: The effect of training dose in fentanyl-saline discrimination (1980) (72)
- Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. (1999) (72)
- Profound, Non-Opioid Analgesia Produced by the High-Efficacy 5-HT1A Agonist F 13640 in the Formalin Model of Tonic Nociceptive Pain (2003) (68)
- N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis. (1990) (65)
- In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia. (2001) (65)
- High-efficacy 5-HT1A agonists for antidepressant treatment: a renewed opportunity. (2007) (64)
- F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. (1998) (63)
- Theoretical and methodological considerations on drug discrimination learning (1976) (63)
- The Neurotransmitter Noradrenaline Rescues Septal Cholinergic Neurons in Culture from Degeneration Caused by Low-Level Oxidative Stress (2005) (63)
- Differential modulation of (+)-amphetamine-induced rotation in unilateral substantia nigra-lesioned rats byα1 as compared toα2 agonists and antagonists (1991) (62)
- Drug Discrimination: Methods of Manipulation, Measurement, and Analysis (1987) (60)
- 5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential. (2001) (60)
- Discovering risperidone: the LSD model of psychopathology (2003) (59)
- F15063, a compound with D2/D3 antagonist, 5‐HT1A agonist and D4 partial agonist properties: (III) Activity in models of cognition and negative symptoms (2007) (58)
- 5-hydroxytryptamine (5-HT)1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr-induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity. (1991) (57)
- Adenosine Prevents the Death of Mesencephalic Dopaminergic Neurons by a Mechanism that Involves Astrocytes (1999) (54)
- Behavioral pharmacology of antagonists at 5-HT2/5-HT1C receptors (1992) (53)
- Drug discrimination : applications in CNS pharmacology : proceedings of the Second International Symposium on Drugs as Discriminative Stimuli held in Beerse, Belgium, on 30 June-3 July, 1982 (1982) (53)
- Chimeric receptor analysis of the ketanserin binding site in the human 5-Hydroxytryptamine1D receptor: importance of the second extracellular loop and fifth transmembrane domain in antagonist binding. (1998) (52)
- Effects of the α2-adrenoreceptor antagonist dexefaroxan on neurogenesis in the olfactory bulb of the adult rat in vivo: selective protection against neuronal death (2003) (52)
- Acetylcholine Release in the Rat Prefrontal Cortex In Vivo: Modulation by α2‐Adrenoceptor Agonists and Antagonists (1997) (52)
- The 5-HT1Dreceptor antagonist GR 127,935 is an agonist at cloned human 5-HT1Dα receptor sites (1995) (51)
- Opioid hyperalgesia and tolerance versus 5-HT1A receptor-mediated inverse tolerance. (2003) (51)
- Agonist and antagonist effects of prototype opiate drugs in rats discriminating fentanyl from saline: characteristics of partial generalization. (1984) (50)
- Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents. (2002) (49)
- α2-Adrenoceptor modulation of cortical acetylcholine release in vivo (1999) (49)
- Symptoms and behavioral features induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in an old java monkey [Macaca cynamolgus fascicularis (Raffles)] (1986) (45)
- The 5-HT(1A) receptor agonist F 13640 attenuates mechanical allodynia in a rat model of trigeminal neuropathic pain. (2002) (44)
- Role of spinal 5‐HT1A receptors in morphine analgesia and tolerance in rats (2004) (43)
- High-efficacy 5-HT1A receptor activation causes a curative-like action on allodynia in rats with spinal cord injury. (2004) (43)
- Fentanyl and apomorphine: Asymmetrical generalization of discriminative stimulus properties (1976) (43)
- Facilitation of Constitutive α2A-Adrenoceptor Activity by Both Single Amino Acid Mutation (Thr373Lys) and Gαo Protein Coexpression: Evidence for Inverse Agonism (2000) (43)
- Behavioral and 5-HT antagonist effects of ritanserin: A pure and selective antagonist of LSD discrimination in rat (2004) (43)
- Factors regulating drug cue sensitivity: Limits of discriminability and the role of a progressively decreasing training dose in cocaine-saline discrimination (1982) (42)
- Continuous Administration of the 5-Hydroxytryptamine1A Agonist (3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl) -amino]-methyl}piperidin-1-yl]-methadone (F 13640) Attenuates Allodynia-Like Behavior in a Rat Model of Trigeminal Neuropathic Pain (2003) (42)
- Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Gαo protein (1999) (42)
- Investigations on drug produced and subjectively experienced discriminative stimuli. 2. Loperamide, an antidiarrheal devoid of narcotic cue producing actions. (1975) (42)
- Cocaine cue in rats as it relates to subjective drug effects: a preliminary report. (1976) (41)
- Activation of noradrenergic transmission by α2-adrenoceptor antagonists counteracts deafferentation-induced neuronal death and cell proliferation in the adult mouse olfactory bulb (2005) (40)
- Region-specific changes in 5-HT1A agonist-induced Extracellular signal-Regulated Kinases 1/2 phosphorylation in rat brain: A quantitative ELISA study (2009) (40)
- High-Efficacy 5-Hydroxytryptamine 1A Receptor Activation Counteracts Opioid Hyperallodynia and Affective Conditioning (2006) (40)
- Amnesic trace locked into the benzodiazepine state of memory (2005) (40)
- Apomorphine as a discriminative stimulus, and its antagonism by haloperidol. (1975) (40)
- Neuroprotective Effects of the α2-Adrenoceptor Antagonists, (+)-Efaroxan and (±)-Idazoxan, against Quinolinic Acid-Induced Lesions of the Rat Striatum (1998) (40)
- Evidence that a preferred substrate for type b monoamine oxidase mediates stimulus properties of MAO inhibitors: A possible role for β-phenylethylamine in the cocaine cue (1980) (39)
- Drug discrimination: no evidence for tolerance to opiates. (1995) (39)
- On the ability of narcotic antagonists to produce the narcotic cue. (1976) (38)
- The ventromedial hypothalamus and the control of avoidance behavior and aggression: fear hypothesis versus response-suppression theory of limbic system function. (1975) (38)
- G‐protein activation by putative antagonists at mutant Thr373Lys α2A adrenergic receptors (1999) (38)
- Pharmacology of cloned human 5-HT1D receptor-mediated functional responses in stably transfected rat C6-glial cell lines: further evidence differentiating human 5-HT1D and 5-HT1B receptors (2004) (38)
- Respiratory effects of morphine in awake unrestrained rats. (1986) (38)
- F15063, a compound with D2/D3 antagonist, 5‐HT1A agonist and D4 partial agonist properties: (II) Activity in models of positive symptoms of schizophrenia (2007) (37)
- A characterization of LSD-antagonist effects of pirenperone in the rat (1983) (37)
- Ligand Binding (2020) (37)
- F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. (1999) (37)
- F15063, a potential antipsychotic with D2/D3 antagonist, 5‐HT1A agonist and D4 partial agonist properties: (I) in vitro receptor affinity and efficacy profile (2007) (37)
- Effects of ventromedial hypothalamic lesions on spontaneous intraspecies aggression in male rats. (1976) (36)
- Effects of phencyclidine-type drugs in rats discriminating fentanyl from saline: pharmacological and behavioral characterization of intermediate levels of drug lever selection. (1993) (35)
- The very-high-efficacy 5-HT1A receptor agonist, F 13640, preempts the development of allodynia-like behaviors in rats with spinal cord injury. (2003) (35)
- Discriminative Stimulus Properties of Benzodiazepines and Barbiturates (1977) (35)
- Nociceptive stimulation prevents development of tolerance to narcotic analgesia. (1978) (34)
- In vivo evidence of partial agonist activity exerted by purported 5-hydroxytryptamine antagonists. (1979) (34)
- Cross generalization with LSD and yohimbine in the rat. (1984) (32)
- Epidural and subcutaneous morphine, meperidine (pethidine), fentanyl and sufentanil in the rat: analgesia and other in vivo pharmacologic effects. (1987) (32)
- Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities. (2007) (31)
- Inhibition of methylphenidate-induced behaviors in rats: differences among neuroleptics. (1993) (31)
- The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes (2005) (31)
- Effects of an alpha2 antagonist ina 20-year-old Java monkey with MPTP-induced parkinsonian signs (1991) (30)
- Pharmacology and antidiarrheal effect of loperamide (1981) (30)
- Beta-Amyloid-Dependent Expression of NOS2in Neurons: Prevention by an α2-Adrenergic Antagonist (2006) (29)
- Ventilatory response to adjuvant arthritis in the rat. (1983) (29)
- Long term catheterization of the lumbar epidural space in rats (1981) (29)
- Studies on the regulation of sensitivity to the narcotic cue (1978) (28)
- Recombinant saphenous vein 5‐HT1B receptors of the rabbit: comparative pharmacology with human 5‐HT1B receptors (1997) (28)
- Epidural and Intravenous Sufentanil in the Rat: Analgesia, Opiate Receptor Binding, and Drug Concentrations in Plasma and Brain (1986) (28)
- Narcotic withdrawal like mouse jumping produced by amphetamine and L-DOPA. (1975) (28)
- Selective antagonism of human 5-HT1D and 5-HT1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935. (1996) (28)
- Blockade of apomorphine's discriminative stimulus properties: Relation to neuroleptic activity in neuropharmacological and biochemical assays (1976) (27)
- α2 Receptors mediate the antinociceptive action of 8-OH-DPAT in the hot-plate test in mice (1991) (27)
- Long-lasting descending and transitory short-term spinal controls on deep spinal dorsal horn nociceptive-specific neurons in response to persistent nociception (2008) (26)
- BEHAVIOURAL PHARMACOLOGY OF NMDA RECEPTOR ANTAGONISTS (1995) (26)
- Cardiovascular drugs inhibit MMP-9 activity from human THP-1 macrophages. (2004) (26)
- The alpha 2-adrenoceptor antagonist, (+)-efaroxan, enhances acetylcholine release in the rat cortex in vivo. (1995) (26)
- A critical study on RO-4-1284 antagonism in mice. (1975) (26)
- Narcotic cueing properties of intraventricularly administered sufentanil, fentanyl, morphine and met-enkephalin. (1978) (25)
- Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study. (2005) (24)
- Discriminative stimulus properties of a low dl-amphetamine dose. (1976) (24)
- Time course of the ventilatory response to adjuvant arthritis in the rat. (1983) (24)
- Ca2+ Responses in Chinese Hamster Ovary-K1 Cells Demonstrate an Atypical Pattern of Ligand-Induced 5-HT1A Receptor Activation (2003) (24)
- F 12511, a novel ACAT inhibitor, and atorvastatin regulate endogenous hypercholesterolemia in a synergistic manner in New Zealand rabbits fed a casein-enriched diet. (2001) (24)
- NLX-112, a highly selective 5-HT1A receptor agonist, mediates analgesia and antidepressant-like activity in rats via spinal cord and prefrontal cortex 5-HT1A receptors, respectively (2018) (23)
- Evidence for protean agonism of RX 831003 at α2A-adrenoceptors by co-expression with different Gα protein subunits (2002) (23)
- Curative-like analgesia in a neuropathic pain model: parametric analysis of the dose and the duration of treatment with a high-efficacy 5-HT(1A) receptor agonist. (2007) (23)
- The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of surgical pain. (2005) (23)
- Investigation of the Mechanism by which Ketanserin Prolongs the Duration of the Cardiac Action Potential (1995) (23)
- Stereoselectivity of 8-OH-DPAT enantiomers at cloned human 5-HT1D receptor sites. (1996) (23)
- Pharmacological profile of F 12511, (S)-2',3', 5'-trimethyl-4'-hydroxy-alpha-dodecylthioacetanilide a powerful and systemic acylcoenzyme A: cholesterol acyltransferase inhibitor. (2001) (22)
- Facilitation of constitutive alpha(2A)-adrenoceptor activity by both single amino acid mutation (Thr(373)Lys) and g(alphao) protein coexpression: evidence for inverse agonism. (2000) (22)
- The narcotic cue: evidence for the specificity of the stimulus properties of narcotic drugs. (1975) (22)
- Beta-amyloid-dependent expression of NOS2 in neurons: prevention by an alpha2-adrenergic antagonist. (2006) (21)
- The discriminative response: an elementary particle of behavior Commentary on Stolerman "Measures of stimulus generalization in drug discrimination experiments" (1991) (21)
- Preclinical antitumour activity of F 11782, a novel dual catalytic inhibitor of topoisomerases (2000) (21)
- The novel analgesic and high-efficacy 5-HT1A receptor agonist, F 13640 induces c-Fos protein expression in spinal cord dorsal horn neurons (2003) (21)
- The shock probe conflict procedure. A new assay responsive to benzodiazepines, barbiturates and related compounds (2004) (21)
- Dual, Hyperalgesic, and Analgesic Effects of the High-Efficacy 5-Hydroxytryptamine 1A (5-HT1A) Agonist F 13640 [(3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, Fumaric Acid Salt]: Relationship with 5-HT1A Receptor Occupancy and Kinetic P (2005) (20)
- Differential ion current activation by human 5-HT1A receptors in Xenopus oocytes: Evidence for agonist-directed trafficking of receptor signalling (2005) (20)
- Stimulation of Cloned Human Serotonin 5‐HT1Dβ Receptor Sites in Stably Transfected C6 Glial Cells Promotes Cell Growth (1996) (20)
- Respiratory Effects of Epidural and Subcutaneous Morphine, Meperidine, Fentanyl and Sufentanil in the Rat (1988) (20)
- Interaction of 5-HT1B/D ligands with recombinant h 5-HT1A receptors:Intrinsic activity and modulation by G-protein activation state (1998) (20)
- In vivo upregulation of endogenous NGF in the rat brain by the alpha 2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration (2004) (20)
- Effects of dorsal raphe stimulation on escape induced by medial hypothalamic or central gray stimulation (1983) (20)
- Apparent hyperalgesic action of the 5-HT1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks (1989) (20)
- Reversal by a central antiacetylcholine drug of pimozideinduced inhibition of mouse‐jumping in amphetamine‐dopa treated mice (1975) (20)
- Ethanol state dependence involving a lever press response requirement in rats. (1999) (19)
- Differential response control by isopropamide: a peripherally induced discriminative cue. (1975) (19)
- Use of a conflict procedure in pigeons to characterize anxiolytic drug activity: evaluation of N-methyl-D-aspartate antagonists. (1991) (19)
- Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists (2003) (19)
- Intrinsic activity and discriminative effects of drugs. (1988) (19)
- Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex (1991) (19)
- Maximal magnitude of effect and potency of putative α‐adrenoceptor agonists in causing CNS depression, in relaxing muscle, and in lowering body temperature in rat (1986) (18)
- OR discrimination: a new drug discrimination method. (1982) (18)
- Ventromedial hypothalamus: Fear conditioning and passive avoidance in rats (1976) (18)
- Tolerance and inverse tolerance to the hyperalgesic and analgesic actions, respectively, of the novel analgesic, F 13640. (2003) (18)
- Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses. (1999) (17)
- Effects of the combined continuous administration of morphine and the high‐efficacy 5‐HT1A agonist, F 13640 in a rat model of trigeminal neuropathic pain (2004) (17)
- Effects of (+/-)-idazoxan alone and in combination with L-DOPA methyl ester in MPTP-induced hemiparkinsonian monkeys. (2003) (17)
- Agonist action at 5-HT1C receptors facilitates 5-HT1A receptor-mediated spontaneous tail-flicks in the rat. (1990) (17)
- Differential haloperidol effect on two indices of fentanyl-saline discrimination (1977) (17)
- Pharmacological analysis of the haemodynamic effects of 5‐HT1B/D receptor agonists in the normotensive rat (1998) (16)
- Epidural and Subcutaneous Morphine, Meperidine (pethidine), Fentanyl and Sufentanil in the Rat: Analgesia and Other in vivo Pharmacologic Effects (1987) (16)
- Disparate ligand‐mediated Ca2+ responses by wild‐type, mutant Ser200Ala and Ser204Ala α2A‐adrenoceptor : Gα15 fusion proteins: evidence for multiple ligand‐activation binding sites (2000) (16)
- Sign-reversal during persistent activation in mu-opioid signal transduction. (2002) (15)
- Heterogeneous ligand-mediated Ca++ responses at wt and mutant α2A-adrenoceptors suggest multiple ligand activation binding sites at the α2A-adrenoceptor (2000) (15)
- G‐protein activation at 5‐HT1A receptors by the 5‐ht1F ligand LY334370 in guinea‐pig brain sections and recombinant cell lines (1998) (15)
- Pharmacological analysis of hyperventilation in arthritic rats (1987) (15)
- Modulation of ligand responses by coupling of α2A-adrenoceptors to diverse Gα-proteins (2001) (15)
- Factors regulating drug cue sensitivity: the effects of dose ratio and absolute dose level in the case of fentanyl dose-dose discrimination. (1982) (14)
- Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: cholesterol O-acyltransferase, on human adrenocortical cells in culture. (2001) (14)
- Discriminative stimulus properties of xylazine in rat: discriminability and effects of putative alpha-2 adrenoceptor agonists and antagonists. (1985) (14)
- 1-5-Hydroxytryptophan-induced flat body posture in the rat: antagonism by ritanserin and potentiation after 5,7-dihydroxytryptamine. (1989) (14)
- Drug-cue conditioning to external stimulus conditions. (1978) (13)
- Na+ currents in cardioprotection: better to be late. (2009) (13)
- Substance dependence. (1998) (13)
- Differential signalling of both wild-type and Thr(343)Arg dopamine D(2short) receptor by partial agonists in a G-protein-dependent manner. (2001) (13)
- [3H]-F13640, a novel, selective and high-efficacy serotonin 5-HT1A receptor agonist radioligand (2010) (13)
- Mechanisms of opioid-induced pain and antinociceptive tolerance: signal transduction (2002) (13)
- Haloperidol blocks the discriminative stimulus properties of lateral hypothalamic stimulation. (1977) (13)
- Dynamic dopamine-antagonist interactions at recombinant human dopamine D(2short) receptor: dopamine-bound versus antagonist-bound receptor states. (2001) (13)
- KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. (2006) (12)
- A possible α2-adrenergic component in the in vivo activity of pirenperone (1984) (12)
- A method for quantifying state-dependency with chlordiazepoxide in rats (2004) (12)
- Experimental realization of a signal transduction algorithm. (1999) (12)
- Selective interference of ACTH4–10 with discriminative responding based on the narcotic cue (1978) (12)
- Analysis of ligand activation of α2-adrenoceptor subtypes under conditions of equal Gα protein stoichiometry (2001) (12)
- A 413 bp region upstream the human 5‐HT1A receptor gene is sufficient for its in vitro expression (1996) (11)
- Memory of an operant response and of depressed mood retained in activation states of 5-HT1A receptors: evidence from rodent models (2000) (11)
- Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats (2002) (11)
- Constitutive Coupling of a Chimeric Dopamine D2/α1 B Receptor to the Phospholipase C Pathway: Inverse Agonism to Silent Antagonism by Neuroleptic Drugs (2003) (11)
- Paradoxical signal transduction in neurobiological systems (2001) (11)
- Ketanserin inhibits the transient outward current in rabbit ventricular myocytes. (1995) (11)
- Modulation of 5-HT1A receptor activation by its interaction with wild-type and mutant Gαi3 proteins (2001) (11)
- Sleeplessness (1885) (10)
- Agonist efficacy at the α2A-adrenoceptor:Gα15 fusion protein: an analysis based on Ca2+ responses (2000) (10)
- Respiratory effects of intrathecal capsaicin in arthritic and non-arthritic rats. (1984) (10)
- Neuroleptic interference with the cocaine cue: Internal stimulus control of behavior and psychosis (1978) (10)
- Parametric effects in the discrimination of intracranial stimulation: Some methodological and analytical issues (1982) (9)
- Real‐time analysis of dopamine: antagonist interactions at recombinant human D2long receptor upon modulation of its activation state (2001) (9)
- Protective effect of the α2-adrenoceptor antagonist, dexefaroxan, against spatial memory deficit induced by cortical devascularization in the adult rat (2004) (9)
- Tacrine-scopolamine interactions on state-dependent retrieval (2003) (8)
- Agonist and antagonist effects of prototype opiate drugs in fentanyl dose-dose discrimination (2004) (8)
- Respiratory effects of epidural morphine and sufentanil in the absence and presence of chlordiazepoxide (1989) (8)
- Disparate ligand-mediated Ca(2+) responses by wild-type, mutant Ser(200)Ala and Ser(204)Ala alpha(2A)-adrenoceptor: G(alpha15) fusion proteins: evidence for multiple ligand-activation binding sites. (2000) (8)
- Intrinsic activity of the non‐prostanoid thromboxane A2 receptor antagonist, daltroban (BM 13,505), in human platelets in vitro and in the rat vasculature in vivo (1995) (8)
- Differentiation between partial and silent 5-HT1dβ receptor antagonists using rat C6-glial and chinese hamster ovary cell lines permanently transfected with a cloned human 5-HT1dβ receptor gene (1995) (8)
- Evidence for protean agonism of RX 831003 at alpha 2A-adrenoceptors by co-expression with different G alpha protein subunits. (2002) (8)
- Donitriptan Selectively Decreases Jugular Venous Oxygen Saturation in the Anesthetized Pig: Further Insights into Its Mechanism of Action Relevant to Headache Relief (2003) (8)
- Increased naloxone reversibility in fentanyl dose-dose discrimination. (1982) (7)
- Molecular cloning and identification of a rabbit saphenous vein 5‐ht1Dβ receptor gene (1996) (7)
- Effects of VMH lesions on CAR learning in cats. (1974) (7)
- Neuroactive steroids and the constraint of memory (1999) (7)
- Induction by Antipsychotics of “Win-Shift” in the Drug Discrimination Paradigm (2007) (7)
- Responses in Chinese Hamster Ovary-K 1 Cells Demonstrate an Atypical Pattern of Ligand-Induced 5-HT 1 A Receptor Activation (2003) (6)
- Donitriptan, a Unique High-Efficacy 5-HT1B/1D Agonist: Key Features and Acute Antimigraine Potential (2006) (6)
- Definite Antitumour Activity ofVinflunine, a Novel Fluorinated Vinca Alkaloid, against Human Tumour Xenografts (1999) (6)
- Evidence for partial agonist properties of daltroban (BM 13,505) at TP receptors in the anæsthetized open-chest rat (1997) (6)
- Narcotic cue and narcotic state: Differential involvement of brain 5-hydroxytryptamine (1977) (6)
- Interactions of haloperidol with discriminative responding controlled by 10 mg/kg of cocaine in rats (1986) (5)
- 8-OH-DPAT-induced corticosterone secretion as an in vivo model of 5-HT1A receptor function (1990) (5)
- Recall of learned information may rely on taking drug again (2009) (5)
- Use of the pithed rat model to determine the relative potencies of 5-HT2A/2C receptor antagonists following acute intravenous and oral administration. (1995) (5)
- Discriminative stimulus properties of analgesic drugs: narcotic versus non-narcotic analgesics. (1976) (5)
- Effects of alpha-methyl-p-tyrosine, adrenolytic compounds, pimozide and other neuroleptics, on the narcotic cue. (1977) (5)
- Drug treatments to reduce excitotoxicity in vivo: a potential for α2-adrenoceptor antagonists? (2000) (4)
- Factors regulating drug cue sensitivity: the effect of frustrative non-reward in fentanyl-saline discrimination. (1981) (4)
- Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins. (2001) (4)
- Continuous administration of the 5-HT 1A agonist, F 13640 attenuates allodynia-like behavior in a rat model of trigeminal neuropathic pain (2003) (4)
- Heterogeneous ligand-mediated Ca(++) responses at wt and mutant alpha(2A)-adrenoceptors suggest multiple ligand activation binding sites at the alpha(2A)-adrenoceptor. (2000) (4)
- Long-term suppression of pain by narcotic drugs in the absence of tolerance development. (1978) (3)
- Analysis of ligand activation of alpha 2-adrenoceptor subtypes under conditions of equal G alpha protein stoichiometry. (2001) (3)
- SYSTEM THEORY : A REPLY TO HOWARD GUTSTEIN (1996) (3)
- Drug Discrimination: A Perspective (2011) (3)
- A mechanism of signal transduction operating with opiate receptors (2001) (3)
- Changes of sensitivity to the cuing properties of narcotic drugs as evidenced by generalization and cross-generalization experiments (1978) (3)
- Drug discrimination in behavioral toxicology. (1987) (3)
- Promotion of cell growth by stimulation of cloned human 5-HT1D receptor sites in transfected C6-glial cells is highly sensitive to intrinsic activity at 5-HT1D receptors (1996) (3)
- Enhancement by Pain and Stress of Analgesia Produced by Epidural Sufentanil in the Rat (1988) (3)
- Sensitization and desensitization to lateral hypothalamic stimulation. (1977) (2)
- Conformational analysis and crystal structure of {[1-(3-chloro-4-fluorobenzoyl)-4-fluoropiperidin-4yl]methyl}[(5-methylpyridin-2-yl)methyl]amine, fumaric acid salt. (2005) (2)
- Modulation of 5-HT(1A) receptor activation by its interaction with wild-type and mutant g(alphai3) proteins. (2001) (2)
- Potentiation of jumping behavior by aminophylline in mice treated with threshold doses of amphentamine and dopa. (1974) (2)
- On the narcotic cuing action of fentanyl and other narcotic analgesic drugs. (1975) (2)
- Differentiation between partial and silent 5-HT1D beta receptor antagonists using rat C6-glial and Chinese hamster ovary cell lines permanently transfected with a cloned human 5-HT1D beta receptor gene. (1995) (2)
- THE a‐SELECTIVE LIGAND NE‐100 ATTENUATES THE EFFECTS OF HIGH DOSES OF DIZOCILPINE IN RATS TRAINED TO DISCRIMINATE DIZOCILPINE FROM SALINE (1998) (2)
- α1, and α2 antagonistics differentially modulate D-amphetamine and apomorphine induced rotation in substantia nigra lesioned rats (1990) (2)
- The 5-HT1D receptor antagonist GR 127,935 is an agonist at cloned human 5-HT1D alpha receptor sites. (1995) (2)
- F-11356 : 5-HT1B/1D RECEPTOR AGONIST ANTIMIGRAINE (1999) (1)
- The narcotic cue A clue to the study of internal stimulus complexes (1979) (1)
- Novel in vivo Models of 5-HT 1A Receptor-Mediated Activity: 8-OH-DPAT-induced Spontaneous Tail-Flicks and Inhibition of Morphine-Evoked-Antinociception (1991) (1)
- A novel in vivo model of 5-HT1A function in the rat: 8-OH-DFAT-induced spontaneous tail-flicks (1990) (1)
- Excitatory Amino Acids and Their Antagonists (2015) (1)
- A possible alpha 2-adrenergic component in the in vivo activity of pirenperone. (1984) (1)
- Overview of the Pharmacological Properties of Daltroban, a Thromboxane A2/Prostanoid‐Receptor Partial Agonist (1998) (1)
- The self-regulation of hypothalamic rewarding brain stimulus after innoculation of Mycobacterium butyricum inducing chronic arthritis (1983) (1)
- State dependency as a mechanism of central nervous system drug action. (1991) (1)
- Catecholamine involvement in the narcotic cue. (1977) (1)
- Ligand-receptor interactions as controlled by wild-type and mutant Thr(370)Lys alpha2B-adrenoceptor-Galpha15 fusion proteins. (2000) (1)
- The European behavioural pharmacology society (2005) (1)
- EFFECTS OF NORADRENALINE DEPLETION BY DSP4 ON NIGROSTRIATAL AND MESOLIMBIC DOPAMINE RELEASE IN VIVO; A MICRODIALYSIS STUDY (1992) (1)
- On the classification of antidepressant drugs (1976) (1)
- State Dependence of Memory (2014) (0)
- 18 TARGETING 5‐HT1A RECEPTOR ACTIVATION IN NEUROPATHIC PAIN (2009) (0)
- Induction of shock-selfadministration by benzodiazepines (1985) (0)
- Product containing milnacipran and idazoxan as combined pharmaceutical preparation (1996) (0)
- SPINAL MECHANISMS IN THE EFFECTS OF FENTANYL AND MORPHINE ON THE RAT TAIL FLICKa) (1981) (0)
- Stimulation of cloned human 5-HT1Dβ receptor sites in permanently transfected C6-glial cells promotes cell proliferation (1995) (0)
- Use of Efaxoran and derivatives thereof for the preparation of medicaments intended for the treatment of neurodegenerative sygdo (1994) (0)
- Aminomethylpiperidinderivate, their methods of preparation and pharmaceutical compositions containing. (1991) (0)
- Naphth-1-yl-piperazine derivatives, process for their preparation and to pharmaceutical compositions containing them (1990) (0)
- Investigation of the mechanism by which ketanserin increases cardiac action potential duration (1995) (0)
- Bisarylalkenderivate, processes for their preparation and pharmaceutical composition containing them. (1990) (0)
- P7 THEH3 ANTAGONIST THIOPERAMIDEPOTENTIATES HYPERACTIVITYBUTDOESNOTAFFECTBEHAVIORAL SENSITIZATION,PLACEPREFERENCEANDCONDITIONED LOCOMOTION INDUCEDBYCOCAINE INC57BL/6JMICE C.Brabant,B.Huyts,E.Quertemont and E.T|relli (2004) (0)
- Cancer pain in animals — do they have it? (1987) (0)
- Pyridin-2-yl-methylamine derivatives for the treatment of opiate addiction (2002) (0)
- Subject Index Vol. 67, 2003 (2003) (0)
- Use of idazoxan and its derivatives for the manufacture of medicaments for the treatment of neurodegenerative diseases and in particular the progression of Alzheimer's disease. (1993) (0)
- Derivatives of 1-Naphthylpiperazin, to processes for their preparation and pharmaceutical compositions containing them. (1990) (0)
- 4-fluorobenzene derivatives, production process and pharmaceutical compositions containing them. (1990) (0)
- 1,2-benzisoxazole derivatives, their methods of preparation and pharmaceutical compositions containing them. (1990) (0)
- Impact of behavioral pharmacology in the pharmaceutical industry (1989) (0)
- 1,2-benzisoxazole derivatives, process for their preparation and to pharmaceutical compositions containing them (1990) (0)
- Antiatherosclerotic effect of the ACAT inhibitor F 12511 in casein-fed New-Zealand rabbit (2000) (0)
- 648 – TOWARDS A DIFFERENTIAL PHARMACOLOGICAL TYPOLOGY OF NARCOTIC AGONISTS AND ANTIDIARRHEALS; COMPARATIVE STUDIES ON FENTANYL AND LOPERAMIDE (1977) (0)
- Aminomethylpiperidinderivater, process for their preparation and to pharmaceutical compositions containing them (1991) (0)
- Obituary (1991) (0)
- New derivatives of aminopiperidine, aminopyrrolidine and Aminoperhydroazepins, methods for preparing and pharmaceutical compositions containing them. (1991) (0)
- Increase in the Behavior of Hypothalamic Autostimulation During Chronic Arthritis in the Rat (1984) (0)
- Agonist efficacy at the alpha2A-adrenoceptor:G alpha15 fusion protein: an analysis based on Ca2+ responses. (2000) (0)
- Novel bisarylalkenderivater, process for their preparation and to pharmaceutical compositions containing them (1990) (0)
- Narcotic cuing and analgesic activity of narcotic analgesics: Associative and dissociative characteristics (1978) (0)
- New 4-fluoro-benzoic derivatives, their processes for preparation and pharmaceutical compositions containing them (1989) (0)
- A SYSTEM THEORY OF SIGNALTRANSDUCTION (1998) (0)
- Ipsilateral flexion reflex response to 5-hydroxytryptamine of the inflamed rat hind limb. (1983) (0)
- [The effect of neuropeptides on the signal function of narcotic analgesics]. (1979) (0)
- 17 Topical Seminar Summary: 5‐HT RECEPTORS AND NEUROPATHIC PAIN (2009) (0)
- Repetitive Behavior (2021) (0)
- Effects of F 12511, a potent ACAT inhibitor, on human adrenocortical cells in culture (1999) (0)
- Evidence that sumatriptan induces hypotension and bradycardia through 5-HT1B/D receptor activation in anesthetized rats (1995) (0)
- Use of efaroxan to the drug used to treat fabricaton of Huntington's disease (1996) (0)
- New derivatives bisaryl-olefins, their methods of preparation and pharmaceutical compositions containing them. (1990) (0)
- New piperidine, tetrahydropytridine and pyrrolidine derivatives, and pharmaceutical composition containing the same (1991) (0)
- OPIATE STATE DEPENDENCE (1998) (0)
- Contents Vol. 67, 2003 (2003) (0)
- New derivatives of piperidine, the tetrahydropyridine and pyrrolidine, their process for the preparation and pharmaceutical compositions containing them. (1990) (0)
- New derivatives of aryl [4-halogeno-4- [(heteroaryl-methylamino) -methyl] -piperidin-1-yl] methanone, their process for the preparation and their use as medicaments (2002) (0)
- Use of derivatives of pyridin-2-yl-methylamine for the preparation of a medicament for the treatment of symptoms of chronic pain of neuropathic or psychogenic (2003) (0)
- New derivatives of amino piperidine, amino pyrrolidine and amino perhydroazepine, their processes for preparation and pharmaceutical compositions containing them. (1990) (0)
- Novel bis(aryl)alkene derivatives, their production and medicinal compositions containing them (1990) (0)
- EFFICACY‐DEPENDENT EFFECTS OF 5‐HT1A AGONISTS (1998) (0)
- Powerful antioxidant acat inhibitors exhibit in vitro anti-inflammatory properties (1999) (0)
- Novel aminomethylpiperidine derivative, its production and pharmaceutical composition containing it (1991) (0)
- F 12511, a novel ACAT inhibitor, and atorvastatin regulate endogenous hypercholesterolemia in a synergistic manner in the casein-fed rabbits (2000) (0)
- Novel 4-fluorbenzoederivater, to processes for their preparation and pharmaceutical compositions containing them (1990) (0)
- Interactions between centrally-induced appetitive effects and centrally or peripherally-induced aversive effects (1982) (0)
- Stimulus properties of drugs and the behavioural pharmacology of pain: in memory of Francis Colpaert (2011) (0)
- Use of idazoxan and its derivatives for the preparation of a medicament for the treatment of Parkinson's disease and its development. (1992) (0)
- 1,2-Benzisoxazolderivate, processes for their preparation, and pharmaceutical compositions containing them. (1990) (0)
- P9 the Septo-Hippocampal Cholinergic Pathway Is Differentially Involved in Contextual Fear Conditioning, Depending on the Predictive Value of a Discrete Conditioned Stimulus: (2004) (0)
- The use of efaroxan and derivatives thereof for the manufacture of a medicament for the treatment of Parkinson's disease (1994) (0)
- New derivatives of naphth-1-yl piperazine, their process for the preparation and pharmaceutical compositions containing them. (1989) (0)
- Molecular cloning of a Chinese hamster lung (CHL) fibroblast cDNA encoding a 5-hydroxytryptamine 1B receptor (1995) (0)
- PARADOXICAL SIGNALTRANSDUCTION OPERATING IN OPIATE SYSTEMS (1998) (0)
- 1,2-benzisoxazole derivative and pharmaceutical composition including the same (1990) (0)
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