Francis J Castellino | Academic Influence

Francis J Castellino's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective (2003) (556)
Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. (2007) (482)
Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C (2007) (304)
Glycosylation of Pichia pastoris ‐derived proteins (1999) (271)
Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. (2012) (255)
Structure and function of the plasminogen/plasmin system. (2005) (254)
The complete amino acid sequence of bovine α-lactalbumin. (1970) (252)
Measurement of the binding of antifibrinolytic amino acids to various plasminogens. (1972) (234)
Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. (2000) (224)
Mice lacking factor VII develop normally but suffer fatal perinatal bleeding (1997) (217)
Examination of the dissociation of multichain proteins in guanidine hydrochloride by membrane osmometry. (1968) (186)
The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin (1997) (175)
Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. (1998) (172)
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. (2009) (163)
The fibrin-derived peptide Bβ15–42 protects the myocardium against ischemia-reperfusion injury (2005) (163)
The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin. (1997) (160)
Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. (2000) (154)
[29] Human plasminogen (1981) (146)
Mechanism of the urokinase-catalyzed activation of human plasminogen. (1976) (139)
Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. (2008) (139)
Oligosaccharide processing in the expression of human plasminogen cDNA by lepidopteran insect (Spodoptera frugiperda) cells. (1990) (136)
FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse. (2002) (134)
Laser-induced noninvasive vascular injury models in mice generate platelet- and coagulation-dependent thrombi. (2001) (133)
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications. (2010) (131)
Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis (1998) (126)
Expression of Three Recombinant Proteins Using Baculovirus Vectors in 23 Insect Cell Lines (1991) (121)
Recent advances in the chemistry of the fibrinolytic system (1981) (118)
Platelet Dysfunction is an Early Marker for Traumatic Brain Injury-Induced Coagulopathy (2012) (118)
The effect of alpha-,omega-amino acids on human plasminogen structure and activation. (1978) (117)
Carbohydrate of the human plasminogen variants. III. Structure of the O-glycosidically linked oligosaccharide unit. (1979) (116)
Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. (2001) (114)
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. (2010) (113)
Plasminogen receptors: the sine qua non of cell surface plasminogen activation. (2005) (111)
Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination (2012) (109)
Carbohydrate of the human plasminogen variants. II. Structure of the asparagine-linked oligosaccharide unit. (1979) (108)
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo. (2009) (102)
Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction (2002) (101)
Asparagine-linked oligosaccharide processing in lepidopteran insect cells. Temporal dependence of the nature of the oligosaccharides assembled on asparagine-289 of recombinant human plasminogen produced in baculovirus vector infected Spodoptera frugiperda (IPLB-SF-21AE) cells. (1991) (98)
A central role for plasminogen in the inflammatory response to biomaterials (2004) (95)
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. (2010) (95)
Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. (2002) (94)
Selective inhibition by kringle 5 of human plasminogen on endothelial cell migration, an important process in angiogenesis. (1998) (90)
The kringle domains of human plasminogen. (1997) (89)
A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. (2000) (86)
Biochemistry of human plasminogen. (1984) (84)
Activation of human plasminogen by equimolar levels of streptokinase. (1977) (82)
Plasma levels of bradykinin are suppressed in factor XII-deficient mice. (2006) (82)
Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats (2014) (81)
Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. (2009) (81)
Kringle 2 Mediates High Affinity Binding of Plasminogen to an Internal Sequence in Streptococcal Surface Protein PAM* (1998) (81)
The Mechanism of the Inhibition of Plasmin Activity by ε-Aminocaproic Acid (1971) (81)
Glucocorticoid stabilization of actin filaments: a possible mechanism for inhibition of corticotropin release. (1992) (80)
A characterization of native streptokinase and altered streptokinase isolated from a human plasminogen activator complex. (1974) (79)
Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen. (1998) (78)
Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1. (2001) (78)
The reciprocal effects of epsilon-aminohexanoic acid and chloride ion on the activation of human [Glu1]plasminogen by human urokinase. (1987) (78)
A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. (2004) (74)
Structures of the asparagine-289-linked oligosaccharides assembled on recombinant human plasminogen expressed in a Mamestra brassicae cell line (IZD-MBO503). (1991) (73)
O‐Mannosylation of Pichia pastoris cellular and recombinant proteins (1998) (73)
The control of the urokinase-catalyzed activation of human glutamic acid 1-plasminogen by positive and negative effectors. (1987) (72)
Role of individual gamma-carboxyglutamic acid residues of activated human protein C in defining its in vitro anticoagulant activity. (1992) (72)
Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces. (2003) (70)
Structural studies on bovine lactoferrin. (1970) (69)
Direct evidence for the generation of an active site in the plasminogen moiety of the streptokinase-human plasminogen activator complex. (1974) (69)
The existence of independent domain structures in human Lys77-plasminogen. (1981) (69)
Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. (2005) (67)
Conversion of Glu-Plasminogen to Lys-Plasminogen Is Necessary for Optimal Stimulation of Plasminogen Activation on the Endothelial Cell Surface* (2001) (66)
Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. (2003) (65)
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. (2007) (65)
Interaction of calcium with bovine plasma protein C. (1981) (65)
The effect of ϵ-amino caproic acid on the gross conformation of plasminogen and plasmin (1975) (62)
Construction, expression, and purification of recombinant kringle 1 of human plasminogen and analysis of its interaction with omega-amino acids. (1991) (62)
Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid. (1996) (61)
A unique enzyme — protein substrate modifier reaction: Plasmin/streptokinase interaction (1979) (60)
Human plasminogen. (1981) (60)
Endothelial Protein C Receptor-Assisted Transport of Activated Protein C across the Mouse Blood—Brain Barrier (2009) (59)
Multiplicity of rabbit plasminogen. Physical characterization. (1972) (58)
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. (2003) (58)
Calcium binding properties of synthetic gamma-carboxyglutamic acid-containing marine cone snail "sleeper" peptides, conantokin-G and conantokin-T. (1996) (58)
Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein. (2001) (58)
Freeze-tolerance adaptations, including haemolymph protein and lipoprotein nucleators, in the larvae of the cranefly Tipula trivittata (1985) (57)
Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. (2010) (56)
Interaction of streptokinase with plasminogen. Isolation and characterization of a streptokinase degradation product. (1976) (56)
Coagulation factor Xa modulates airway remodeling in a murine model of asthma. (2007) (55)
Domain interactions between streptokinase and human plasminogen. (2001) (55)
Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers. (2004) (55)
Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation (2011) (55)
Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit. (1999) (55)
Rotational diffusion analysis of the conformational alterations produced in plasminogen by certain antifibrinolytic amino acids. (1973) (54)
A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. (2005) (54)
Regulation of plasminogen activation on cell surfaces and fibrin (2018) (52)
A Novel Function of Plasminogen Activator Inhibitor-1 in Modulation of the AKT Pathway in Wild-type and Plasminogen Activator Inhibitor-1-deficient Endothelial Cells* (2006) (51)
A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate. (2004) (51)
The presence of UDP-N-acetylglucosamine:alpha-3-D-mannoside beta 1,2-N-acetylglucosaminyltransferase I activity in Spodoptera frugiperda cells (IPLB-SF-21AE) and its enhancement as a result of baculovirus infection. (1993) (50)
The Amino Acid Residue at Sequence Position 5 in the Conantokin Peptides Partially Governs Subunit-selective Antagonism of RecombinantN-Methyl-d-aspartate Receptors* (2001) (50)
Enhanced in Vitro Proliferation of Aortic Endothelial Cells from Plasminogen Activator Inhibitor-1-deficient Mice* (2004) (50)
Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge. (2002) (49)
A gamma-carboxyglutamic acid (gamma) variant (gamma 6D, gamma 7D) of human activated protein C displays greatly reduced activity as an anticoagulant. (1990) (49)
Mapping of disulfide bridges in antifreeze proteins from overwintering larvae of the beetle Dendroides canadensis. (1998) (49)
Effectors of the activation of human [Glu1]plasminogen by human tissue plasminogen activator. (1988) (48)
Rapid selection of Drosophila S2 cells with the puromycin resistance gene. (2003) (48)
Expression of human plasminogen in Drosophila Schneider S2 cells. (1999) (47)
Interaction of streptokinase and rabbit plasminogen. (1973) (46)
The denaturing effectiveness of guanidinium, carbamoylguanidinium, and guanylguanidinium salts. (1968) (46)
Effects of human fibrinogen and its cleavage products on activation of human plasminogen by streptokinase. (1985) (45)
alpha-Mannosidase-catalyzed trimming of high-mannose glycans in noninfected and baculovirus-infected Spodoptera frugiperda cells (IPLB-SF-21AE). A possible contributing regulatory mechanism for assembly of complex-type oligosaccharides in infected cells. (1991) (45)
A coagulation factor VII deficiency protects against acute inflammatory responses in mice (2006) (44)
Thermodynamic properties of the binding of alpha-, omega-amino acids to the isolated kringle 4 region of human plasminogen as determined by high sensitivity titration calorimetry. (1990) (44)
Generation of genetically-altered mice producing very low levels of coagulation factorVII. (2005) (43)
Essential role of caldesmon in the actin filament reorganization induced by glucocorticoids (1995) (43)
The protein C pathway and pathologic processes (2009) (42)
Plasminogen activator activities of equimolar complexes of streptokinase with variant recombinant plasminogens. (1990) (42)
The interaction of Ca2+ with human Factor IX. (1981) (42)
Purification and characterization of crotonase from Clostridium acetobutylicum. (1972) (42)
The Carboxymethylation of Bovine α-Lactalbumin (1970) (41)
The binding energy of human coagulation protein C to acidic phospholipid vesicles contains a major contribution from leucine 5 in the gamma-carboxyglutamic acid domain. (1994) (41)
Chemical and physical properties of serum transferrins from several species. (1973) (40)
Role of lysine binding regions in the kinetic properties of human plasmin. (1981) (39)
Amino acid residues of the kringle-4 and kringle-5 domains of human plasminogen that stabilize their interactions with omega-amino acid ligands. (1994) (39)
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage (2012) (39)
Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between". (2017) (38)
Activation of human neo-plasminogen-Val442 by urokinase and streptokinase and a kinetic characterization of neoplasmin-Val442. (1980) (38)
Nonfibrinolytic functions of plasminogen. (2000) (37)
Hydrophobic amino acid residues of human anticoagulation protein C that contribute to its functional binding to phospholipid Vesicles. (1995) (37)
Conformational Changes in Conantokin-G Induced upon Binding of Calcium and Magnesium as Revealed by NMR Structural Analysis* (1998) (37)
Conformational properties of streptokinase. (1989) (37)
The binding-sites of rabbit muscle aldolase. (1966) (37)
The mechanism of activation of rabbit plasminogen by urokinase. (1975) (37)
Mechanism of activation of human plasminogen by the activator complex, streptokinase-plasmin. (1978) (36)
Role of the hexapeptide disulfide loop present in the gamma-carboxyglutamic acid domain of human protein C in its activation properties and in the in vitro anticoagulant activity of activated protein C. (1991) (36)
The characterization of mice with a targeted combined deficiency of protein c and factor XI. (2001) (35)
The molecular basis of conantokin antagonism of NMDA receptor function. (2007) (35)
Molecular weight and subunit structure of yeast enolase. (1970) (34)
A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis. (2008) (34)
Monoclonal antibodies to discrete regions of human Glu1-plasminogen. (1982) (34)
Development of Pulmonary Fibrosis in Fibrinogen‐Deficient Mice (2001) (34)
Contributions of individual kringle domains toward maintenance of the chloride-induced tight conformation of human glutamic acid-1 plasminogen. (1995) (34)
Stimulation of the amidase and esterase activity of activated bovine plasma protein C by monovalent cations. (1980) (34)
Overwintering adaptations of the stag beetle,Ceruchus piceus: removal of ice nucleators in the winter to promote supercooling (2004) (34)
Plasmin-mediated fibrinolysis by variant recombinant tissue plasminogen activators. (1989) (34)
The contributions of individual gamma-carboxyglutamic acid residues in the calcium-dependent binding of recombinant human protein C to acidic phospholipid vesicles. (1993) (33)
Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy (2016) (33)
Plasminogen inhibits TNFα-induced apoptosis in monocytes (2006) (33)
A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins (2008) (33)
Amino acids of the recombinant kringle 1 domain of human plasminogen that stabilize its interaction with omega-amino acids. (1993) (33)
Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system. (1989) (33)
The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin. (2002) (33)
Regulation of the streptokinase-mediated activation of human plasminogen by fibrinogen and chloride ions. (1986) (32)
Thermodynamics of Binding of Calcium, Magnesium, and Zinc to theN-Methyl-d-aspartate Receptor Ion Channel Peptidic Inhibitors, Conantokin-G and Conantokin-T* (1998) (32)
N-methyl-d-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein (2008) (32)
Characterization of Streptokinases from Group A Streptococci Reveals a Strong Functional Relationship That Supports the Coinheritance of Plasminogen-binding M Protein and Cluster 2b Streptokinase* (2012) (32)
Purification and properties of a Golgi-derived (alpha 1,2)-mannosidase-I from baculovirus-infected lepidopteran insect cells (IPLB-SF21AE) with preferential activity toward mannose6-N-acetylglucosamine2. (1995) (32)
Calorimetric evaluation of the existence of separate domains in bovine prothrombin. (1981) (32)
Purification and properties of alpha-mannosidase II from Golgi-like membranes of baculovirus-infected Spodoptera frugiperda (IPLB-SF-21AE) cells. (1997) (32)
Calcium and phospholipid binding properties of synthetic gamma-carboxyglutamic acid-containing peptides with sequence counterparts in human protein C. (1994) (31)
A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice. (2006) (31)
A Natural Inactivating Mutation in the CovS Component of the CovRS Regulatory Operon in a Pattern D Streptococcal pyogenes Strain Influences Virulence-associated Genes* (2013) (31)
The binding of metal ions to bovine factor IX. (1978) (31)
Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation. (2017) (31)
Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. (2011) (30)
Structure-Function Analysis of the Streptokinase Amino Terminus (Residues 1–59)* (2003) (30)
The role of sialic acid in the determination of distinct properties of the isozymes of rabbit plasminogen. (1974) (30)
Maternal fibrinogen is necessary for embryonic development. (2005) (30)
Human protein C and activated protein C Components of the human anticoagulation system. (1995) (30)
Amino terminal amino acid sequences and carbohydrate of the two major forms of rabbit plasminogen. (1973) (30)
Conservation of Critical Functional Domains in Murine Plasminogen Activator Inhibitor-1* (2004) (30)
[23] Rabbit plasminogen and plasmin isozymes (1976) (30)
Characterization of the acidic oligosaccharides assembled on the Pichia pastoris‐expressed recombinant kringle 2 domain of human tissue‐type plasminogen activator (1997) (29)
Kinetic studies of the role of monovalent cations in the amidolytic activity of activated bovine plasma protein C. (1982) (29)
Fibrinogen has chaperone-like activity. (2009) (29)
Contributions of thrombin targets to tissue factor‐dependent metastasis in hyperthrombotic mice (2014) (29)
A Fast-acting, Modular-structured Staphylokinase Fusion with Kringle-1 from Human Plasminogen as the Fibrin-targeting Domain Offers Improved Clot Lysis Efficacy* (2003) (29)
Roles of individual kringle domains in the functioning of positive and negative effectors of human plasminogen activation. (1995) (29)
Glycosylationproperties of the Pichia pastoris‐expressed recombinant kringle 2 domain oftissue‐type plasminogen activator (1997) (29)
Activation of human plasminogen by staphylokinase. Direct evidence that preformed plasmin is necessary for activation to occur. (1997) (29)
Enhancement of the streptokinase-catalyzed activation of human plasminogen by human fibrinogen and its plasminolysis products. (1982) (28)
Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4. (2016) (28)
Cation binding properties of the multiple subforms of RVV-X, the coagulant protein from Vipera russelli. (1982) (28)
Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model. (2013) (28)
Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation. (2006) (28)
Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence (2014) (27)
Molecular mechanisms of fibrinolysis in man. (1978) (27)
A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. (2016) (27)
A kinetic evaluation of activated bovine blood coagulation factor IX toward synthetic substrates. (1980) (27)
The activation of human [Glu1]plasminogen by human single-chain urokinase (1988) (27)
Fas/CD95 Deficiency in ApcMin/+ Mice Increases Intestinal Tumor Burden (2010) (27)
An internal histidine residue from the bacterial surface protein, PAM, mediates its binding to the kringle-2 domain of human plasminogen. (2000) (27)
The Roles of Individual γ-Carboxyglutamate Residues in the Solution Structure and Cation-dependent Properties of Conantokin-T* (1998) (27)
Plasminogen Enhances Neuritogenesis on Laminin-1 (2009) (27)
Functional independence of the kringle 4 and kringle 5 regions of human plasminogen. (1993) (26)
Interaction of lysophosphatidylcholine with phosphatidylcholine bilayers. A photo-physical and NMR study. (1980) (26)
Purification and characterization of an insect hemolymph lipoprotein ice nucleator: evidence for the importance of phosphatidylinositol and apolipoprotein in the ice nucleator activity (2004) (26)
Purification and characterization of antifreeze proteins from larvae of the beetle Dendroides canadensis (2004) (26)
A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues. (2004) (26)
Glycosylation of Asparagine-28 of Recombinant Staphylokinase with High-Mannose-type Oligosaccharides Results in a Protein with Highly Attenuated Plasminogen Activator Activity* (1999) (25)
Purification and composition of an ice nucleating protein from queens of the hornet,Vespula maculata (2004) (25)
Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen. (2008) (25)
Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice. (2008) (25)
Functional Dissection of Streptococcus pyogenes M5 Protein: the Hypervariable Region is Essential for Virulence (2009) (25)
Factor VII Deficiency Impairs Cutaneous Wound Healing in Mice (2010) (25)
Gene targeting of components of the fibrinolytic system. (2002) (25)
The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine. (2012) (25)
The influence of metal ions in the activation of bovine factor IX by the coagulant protein of Russell's viper venom. (1978) (25)
Characterization of Transcriptional Regulatory Elements in the Promoter Region of the Murine Blood Coagulation Factor VII Gene* (1998) (24)
Serine-578 is a major phosphorylation locus in human plasma plasminogen. (1997) (24)
The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif. (2007) (24)
Reductive amination with tritylamine as an ammonia equivalent : efficient preparation of the 5-[4-[[9-fluorenylmethyloxycarbonyl)-amino]methyl]-3,5-dimethoxyphenoxy]valeric acid (PAL) handle for peptide synthesis (1993) (24)
The binding of calcium to the activation products of bovine factor IX. (1979) (24)
Appearance of plasminogen activator activity during a synchronous cycle of a rat adenocarcinoma cell line, PA-III. (1987) (24)
Kinetic mechanism for stimulation by monovalent cations of the amidase activity of the plasma protease bovine activated protein C. (1985) (24)
Attenuation of Neointima Formation Following Arterial Injury in PAI‐1 Deficient Mice (2001) (23)
Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury. (2016) (23)
The binding of calcium to bovine factor VII. (1980) (23)
Functions of individual gamma-carboxyglutamic acid (Gla) residues of human protein c. Determination of functionally nonessential Gla residues and correlations with their mode of binding to calcium. (1994) (23)
Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps (2016) (23)
The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. (2003) (23)
Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis (2016) (23)
Delayed inflammatory responses to endotoxin in fibrinogen‐deficient mice (2006) (23)
Activated protein C attenuates coagulation‐associated over‐expression of fibrinolytic activity by suppressing the thrombin‐dependent inactivation of PAI‐1 (2003) (22)
Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons (1999) (22)
The NMR solution structure of the NMDA receptor antagonist, conantokin‐T, in the absence of divalent metal ions (1997) (22)
Sequence Requirements for theN-Methyl-d-aspartate Receptor Antagonist Activity of Conantokin-R* (2001) (22)
Structure–function relationships of the NMDA receptor antagonist peptide, conantokin‐R (2000) (22)
Modulation of fibrin assembly and polymerization by the beta-amyloid of Alzheimer's disease. (1996) (22)
Characterization of a cDNA encoding murine coagulation factor VII. (1996) (22)
Interaction of manganese with bovine factor X. (1977) (22)
Complement-mediated Opsonization of Invasive Group A Streptococcus pyogenes Strain AP53 Is Regulated by the Bacterial Two-component Cluster of Virulence Responder/Sensor (CovRS) System* (2013) (22)
Endogenous plasmin converts Glu‐plasminogen to Lys‐plasminogen on the monocytoid cell surface (2003) (22)
Oligosaccharide structures present on asparagine-289 of recombinant human plasminogen expressed in a Chinese hamster ovary cell line. (1991) (22)
Subtype-selective antagonism of N-methyl-d-aspartate receptor ion channels by synthetic conantokin peptides (2007) (22)
NMDA‐receptor antagonist requirements in conantokin‐G (1998) (21)
Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation (2017) (21)
Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. (2014) (21)
Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein* (2015) (21)
Role of tryptophan-74 of the recombinant kringle 2 domain of tissue-type plasminogen activator in its omega-amino acid binding properties. (1992) (21)
Influence of specific gamma-carboxyglutamic acid residues on the integrity of the calcium-dependent conformation of human protein C. (1992) (21)
31P-nuclear magnetic resonance and 31P(1H) nuclear Overhauser effect analysis of mixed egg phosphatidylcholine-sodium taurocholate vesicles and micelles. (1979) (20)
A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice. (2009) (20)
NR2B-selective conantokin peptide inhibitors of the NMDA receptor display enhanced antinociceptive properties compared to non-selective conantokins (2008) (20)
Rapid formation of an anion-sensitive active site in stoichiometric complexes of streptokinase and human [Glu1]plasminogen. (1986) (20)
Structure-function relationships of the NMDA receptor antagonist conantokin peptides. (2001) (20)
X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM. (2006) (20)
Pharmacology of triheteromeric N-Methyl-d-Aspartate Receptors (2016) (20)
Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury. (2014) (20)
Isolation of human Val354 -plasminogen as an elastolytic fragment of human Glu1 -plasminogen. (1981) (20)
The genetic relationships between the kringle domains of human plasminogen, prothrombin, tissue plasminogen activator, urokinase, and coagulation factor XII (2005) (20)
Direct identification of lysine-33 as the principal cationic center of the omega-amino acid binding site of the recombinant kringle 2 domain of tissue-type plasminogen activator. (1992) (20)
α Domain Deletion Converts Streptokinase into a Fibrin-dependent Plasminogen Activator through Mechanisms Akin to Staphylokinase and Tissue Plasminogen Activator* (2004) (20)
Electron microscopic identification of exposed plasmin epitopes in alpha 2-macroglobulin-plasmin complex using monoclonal antibody-colloidal gold adducts. (1988) (20)
Human plasma lipoproteins as accelerators of prothrombin activation. (1976) (20)
Interaction of manganese with bovine prothrombin and its thrombin-mediated cleavage products. (1976) (20)
In utero transplantation of wild‐type fetal liver cells rescues factor X‐deficient mice from fatal neonatal bleeding diatheses (2003) (19)
A deficiency of uPAR alters endothelial angiogenic function and cell morphology (2011) (19)
Synthesis, purification, and properties of a peptide that enhances the activation of human [Glu1]plasminogen by tissue plasminogen activator and retards fibrin polymerization. (1990) (19)
Purification and properties of a plasminogen activator from cultured rat prostate adenocarcinoma cells. (1983) (19)
Activation of human plasminogen by staphylokinase. Direct evidence that preformed plasmin is necessary for activation to occur. (1997) (19)
Interaction of human plasmin with human alpha 2-macroglobulin. (1984) (19)
Binding of calcium to individual gamma-carboxyglutamic acid residues of human protein C. (1995) (19)
Unique Genomic Arrangements in an Invasive Serotype M23 Strain of Streptococcus pyogenes Identify Genes That Induce Hypervirulence (2014) (19)
Amino acid sequence analysis of the asparagine-288 region of the carbohydrate variants of human plasminogen. (1983) (19)
Solubility of amino acids in aqueous guanidinium thiocyanate solutions. (1972) (19)
Isolation and characterization of native and lower molecular weight forms of sheep plasminogen. (1977) (19)
Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review. (2019) (18)
The cationic locus on the recombinant kringle 2 domain of tissue-type plasminogen activator that stabilizes its interaction with omega-amino acids. (1992) (18)
Effect of methylamine and plasmin on the conformation of human alpha 2-macroglobulin as revealed by differential scanning calorimetric analysis. (1984) (18)
Specific anionic residues of the recombinant kringle 2 domain of tissue-type plasminogen activator that are responsible for stabilization of its interaction with omega-amino acid ligands. (1993) (18)
Purification and some properties of the Glu- and Lys-human plasmin heavy chains. (1977) (18)
Cathepsin E Is a Specific Marker of Dysplasia in APCMin/+ Mouse Intestine (2005) (18)
Nucleotide structure and characterization of the murine blood coagulation factor VII gene. (1996) (18)
Adsorption of bovine prothrombin to spread phospholipid monolayers. (1997) (18)
A differential scanning calorimetric investigation of the domains of recombinant tissue plasminogen activator. (1988) (18)
The binding of antifibrinolytic amino acids to kringle-4-containing fragments of plasminogen. (1984) (18)
Metal-ion-binding properties of synthetic conantokin-G. (1997) (18)
Role of tryptophan-63 of the kringle 2 domain of tissue-type plasminogen activator in its thermal stability, folding, and ligand binding properties. (1997) (18)
The influence of the nature of the asparagine 289-linked oligosaccharide on the activation by urokinase and lysine binding properties of natural and recombinant human plasminogens. (1993) (18)
A monoclonal antibody to the epsilon-aminocaproic acid binding site on the kringle 4 region of human plasminogen that accelerates the activation of Glu1-plasminogen by urokinase. (1985) (18)
A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide. (2004) (18)
Enhancement through Mutagenesis of the Binding of the Isolated Kringle 2 Domain of Human Plasminogen to ω-Amino Acid Ligands and to an Internal Sequence of a Streptococcal Surface Protein* (1999) (18)
Helix-Helix Interactions between Homo- and Heterodimeric γ-Carboxyglutamate-containing Conantokin Peptides and Their Derivatives* (2007) (18)
Influence of various structural domains of fibrinogen and fibrin on the potentiation of plasminogen activation by recombinant tissue plasminogen activator (1989) (18)
The Lack of Binding of VEK-30, an Internal Peptide from the Group A Streptococcal M-like Protein, PAM, to Murine Plasminogen Is due to Two Amino Acid Replacements in the Plasminogen Kringle-2 Domain* (2008) (17)
Tranexamic Acid for Trauma Resuscitation in the United States of America (2017) (17)
Reaction of tissue-type plasminogen activator with 4-methylumbelliferyl-p-guanidinobenzoate hydrochloride. (1988) (17)
A Key Role for the Urokinase Plasminogen Activator (uPA) in Invasive Group A Streptococcal Infection (2013) (17)
Recognition of plasminogen activator inhibitor type 1 as the primary regulator of fibrinolysis. (2019) (16)
A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice (2008) (16)
The fibrinolytic system--basic considerations. (1979) (16)
Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity (2016) (16)
Examination of the secondary structure of the kringle 4 domain of human plasminogen. (1986) (16)
CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants (2015) (16)
The interaction of bovine factor IX, its activation intermediate, factor IX alpha, and its activation products, factor IXa alpha and factor IXa beta, with acidic phospholipid vesicles of various compositions. (1986) (16)
Metal ion specificity of the conversion of bovine factors IX, IX alpha, and IXa alpha to bovine factor IXa beta. (1980) (16)
Carbohydrate compositions of the rabbit plasminogen isozymes. (1975) (16)
Solution structure of the complex of VEK-30 and plasminogen kringle 2. (2010) (16)
Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β‐domains (2013) (15)
Effect of monovalent cations on the pre-steady-state kinetic parameters of the plasma protease bovine activated protein C. (1985) (15)
Modification of bovine alpha-lactalbumin with N-bromosuccinimide and 2-hydroxy-5-nitrobenzylbromide. (1975) (15)
A comparison of steady- and presteady-state kinetics of bovine and human plasmins. (1972) (15)
The complete amino acid sequence of bovine alpha-lactalbumin. (1970) (15)
Expression, purification, and characterization of the recombinant kringle 1 domain from tissue-type plasminogen activator. (1992) (15)
The generation and characterization of mice expressing a plasmin‐inactivating active site mutation (2010) (15)
Solution structure and functional characterization of human plasminogen kringle 5. (2009) (14)
Amino acid determinants for NMDA receptor inhibition by conantokin‐T (2001) (14)
Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice (2006) (14)
Human Plasminogen: Structure, Activation, and Function (2003) (14)
Characterization of the murine coagulation factor X promoter. (2000) (14)
Abrogation of Plasminogen Activator Inhibitor-1-Vitronectin Interaction Ameliorates Acute Kidney Injury in Murine Endotoxemia (2015) (14)
Stimulation by fibrinogen of the amidolytic activity of single-chain tissue plasminogen activator. (1989) (14)
The activities of recombinant gamma-carboxyglutamic-acid-deficient mutants of activated human protein C toward human coagulation factor Va and factor VIII in purified systems and in plasma. (1994) (14)
Inhibition of MK801 binding in adult rat brain sections by conantokin-G and conantokin-T (1999) (14)
Conantokins inhibit NMDAR-dependent calcium influx in developing rat hippocampal neurons in primary culture with resulting effects on CREB phosphorylation (2010) (14)
Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-d-aspartate receptors (2010) (14)
Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion (2017) (14)
Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection (2018) (14)
High‐level secretion in Pichia pastoris and biochemical characterization of the recombinantkringle 2 domain of tissue‐type plasminogen activator (1997) (14)
Characterization of a Reduced Form of Plasma Plasminogen as the Precursor for Angiostatin Formation* (2013) (14)
Construction, expression, and properties of a recombinant chimeric human protein C with replacement of its growth factor-like domains by those of human coagulation factor IX. (1994) (14)
ROLE OF VITAMIN A IN GAMMA GLOBULIN BIOSYNTHESIS AND URIC ACID METABOLISM OF MONGOLOIDS. (1964) (13)
Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T. (1999) (13)
Thromboelastography in Orthopaedic Trauma Acute Pelvic Fracture Resuscitation: A Descriptive Pilot Study (2016) (13)
Dimerization Is Not a Determining Factor for Functional High Affinity Human Plasminogen Binding by the Group A Streptococcal Virulence Factor PAM and Is Mediated by Specific Residues within the PAM a1a2 Domain* (2014) (13)
Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria* (2016) (13)
Gene targeting in hemostasis: protein C. (2001) (13)
NMR backbone dynamics of VEK-30 bound to the human plasminogen kringle 2 domain. (2010) (13)
Conantokin-G Attenuates Detrimental Effects of NMDAR Hyperactivity in an Ischemic Rat Model of Stroke (2015) (13)
Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice (2009) (13)
The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors. (2014) (13)
Structure-function assessment of the role of the helical stack domain in the properties of human recombinant protein C and activated protein C. (1995) (13)
Conantokins: inhibitors of ion flow through the N-methyl-D-aspartate receptor channels. (2000) (13)
A urokinase‐type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice (2007) (13)
Properties of recombinant chimeric human protein C and activated protein C containing the gamma-carboxyglutamic acid and trailing helical stack domains of protein C replaced by those of human coagulation factor IX. (1994) (13)
Streptokinase-plasmin(ogen) activator assays. (1993) (13)
Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides (2001) (13)
The stimulation by monovalent cations of the amidase activity of bovine des-1-41 light chain activated protein C. (1986) (12)
The effect of epsilon-amino caproic acid on the gross conformation of plasminogen and plasmin. (1975) (12)
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B (2009) (12)
Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48 (2018) (12)
Plasminogen inhibits TNFalpha-induced apoptosis in monocytes. (2006) (12)
Metabolic turnover studies on the two major forms of rat and rabbit plasminogen. (1974) (12)
The effects of ligand binding on the backbone dynamics of the kringle 1 domain of human plasminogen. (2000) (12)
Kinetic comparison of bovine blood coagulation factors IXa alpha and IXa beta toward bovine factor X. (1983) (12)
The hydrophobic nature of residue-5 of human protein C is a major determinant of its functional interactions with acidic phospholipid vesicles. (1996) (12)
Monoclonal antibodies detect receptor-induced binding sites in Glu-plasminogen. (2011) (12)
Control of human plasminogen activation. (1988) (11)
The importance of the hydrophobic components of the binding energies in the interaction of omega-amino acid ligands with isolated kringle polypeptide domains of human plasminogen. (1995) (11)
Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen (2017) (11)
Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII. (2017) (11)
Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene. (2006) (11)
Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice. (2000) (11)
Effect of tunicamycin on appearance of carbohydrate variants of plasminogen in rat and rabbit plasma. (1981) (11)
Nucleotide structure and characterization of the murine gene encoding anticoagulant protein C. (1998) (11)
The inhibition of the enzymic activity of blood coagulation and fibrinolytic serine proteases by a new leupeptin-like inhibitor, and its structural analogues, isolated from Streptomyces griseus. (1989) (10)
Microviscosity of the lipid domains of normal and hypercholesterolemic very low density lipoprotein. (1977) (10)
The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice. (2004) (10)
Adsorption of vitamin K-dependent blood coagulation proteins to spread phospholipid monolayers as determined from combined measurements of the surface pressure and surface protein concentration. (1998) (10)
Involvement of tyrosine-76 of the kringle 2 domain of tissue-type plasminogen activator in its thermal stability and its omega-amino acid ligand binding site. (1994) (10)
Properties of a recombinant chimeric protein in which the gamma-carboxyglutamic acid and helical stack domains of human anticoagulant protein C are replaced by those of human coagulation factor VII. (1997) (10)
Structural determinants of the noncatalytic chain of tissue-type plasminogen activator that modulate its association rate with plasminogen activator inhibitor-1. (1990) (10)
Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization. (2018) (10)
Nucleotide structure and characterization of the murine gene encoding the endothelial cell protein C receptor. (1999) (10)
Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG (2014) (10)
205Tl+ as a spectroscopic probe of the monovalent cation binding sites of bovine plasma activated protein C and des-1-41-light-chain-activated protein C. (1987) (9)
Role of the strictly conserved tryptophan-25 residue in the stabilization of the structure and in the ligand binding properties of the kringle 2 domain of tissue-type plasminogen activator. (1994) (9)
The role of the lysine binding sites of human plasmin in the hydrolysis of human fibrinogen. (1983) (9)
The chemical synthesis of the chromogenic substrates, H-D-Val-L-Leu-L-Lys-p-nitroanilide (S2251) and H-D-Ile-L-Pro-L-ARG-p-nitroanilide (S2288). (1990) (9)
Involvement of histidine-32 in the biological activity of alpha-lactalbumin. (1979) (9)
The plasminogen receptor, Plg‐RKT, is essential for mammary lobuloalveolar development and lactation (2018) (9)
Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted γ-carboxyglutamate residues (2009) (9)
Roles for chloride ion and fibrinogen in the activation of [Glu1]plasminogen in human plasma. (1988) (9)
31P NMR analysis of the surface homogeneity of mixed sphingomyelin-phosphatidylcholine vesicles. (1978) (9)
Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen. (2019) (9)
Direct binding properties of conantokins to native N-methyl-d-aspartate receptors. (2003) (8)
Expression of human plasminogen cDNA in lepidopteran insect cells and analysis of asparagine-linked glycosylation patterns of recombinant plasminogens. (1993) (8)
Immunological comparison of native streptokinase with streptokinase fragments. (1976) (8)
The mechanism of activation of rabbit plasminogen by urokinase. Lack of a preactivation peptide. (1974) (8)
Increased expression of NR2A subunit does not alter NMDA‐evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons (2001) (8)
alpha Domain deletion converts streptokinase into a fibrin-dependent plasminogen activator through mechanisms akin to staphylokinase and tissue plasminogen activator. (2004) (8)
A comparison of the urokinase and streptokinase activation properties of the native and lower molecular weight forms of sheep plasminogen. (1979) (8)
Abnormal Whole Blood Thrombi in Humans with Inherited Platelet Receptor Defects (2012) (8)
A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke. (2018) (8)
Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding. (2019) (8)
Isolation of a streptokinase cofactor from rabbit plasma. (1980) (8)
The effect of monovalent cations on the pre-steady state reaction kinetics of bovine activated plasma protein C and des-1-41-light chain activated plasma protein C. (1987) (8)
Ca 2+-induced self-assembly in designed peptides with optimally spaced gamma-carboxyglutamic acid residues. (2011) (8)
The binding of Mn2+ to bovine plasma protein C, des(1-41)-light chain protein C, and activated des(1-41)-light chain activated protein C. (1987) (8)
The activation of bovine factor X by bovine factor Xa. (1982) (8)
Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors (2012) (8)
Activators and inhibitors of the ion channel of the NMDA receptor. (2001) (7)
Mechanisms for Mortality Reduction by Activated Protein C in Severe Sepsis. (2006) (7)
Highly conserved residue arginine-15 is required for the Ca2+-dependent properties of the gamma-carboxyglutamic acid domain of human anticoagulation protein C and activated protein C. (1997) (7)
A Case of Successful Thromboelastographic Guided Resuscitation after Postpartum Hemorrhage and Cardiac Arrest. (2016) (7)
Cloning and characterization of the murine coagulation factor X gene. (2000) (7)
An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia. (2011) (7)
Rabbit plasminogen and plasmin isozymes. (1976) (7)
The entire gamma-carboxyglutamic acid- and helical stack-domains of human coagulation factor IX are required for optimal binding to its endothelial cell receptor. (1996) (7)
The effect of guanidinium, carbamoylguanidinium, and guanylguanidinium salts on the solubility of benzoyl-L-tyrosine ethyl ester and acetyltetraglycine ethyl ester in water. (1969) (7)
Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potential for evolutionary persistence. (2016) (7)
Synthetic conantokin peptides potently inhibit N‐methyl‐D‐aspartate receptor‐mediated currents of retinal ganglion cells (2014) (6)
Interspecies cross-reactivity of monoclonal antibodies to various epitopes of human plasminogen. (1984) (6)
The kinetic assembly of the intrinsic bovine factor X activation system. (1989) (6)
The thermotropic properties of human plasma fibronectin. (1985) (6)
The role of the lysine binding sites of human plasminogen in the fibrinogen stimulated rate of active site formation in the streptokinase-plasminogen equimolar complex. (1984) (6)
The effect of divalent cations on the amidolytic activity of bovine plasma activated protein C and des-1-41-light chain activated protein C. (1987) (6)
Chapter 6 – The Structure and Activation of Human Plasminogen (1990) (6)
De novo biosynthesis of plasminogen in the anephric rat. (1975) (6)
Heteromerization of Ligand Binding Domains of N-Methyl-d-Aspartate Receptor Requires Both Coagonists, l-Glutamate and Glycine (2015) (6)
The activation of human [Glu1]plasminogen by human single-chain urokinase. (1988) (6)
Functional consequences of mutations in amino acid residues that stabilize calcium binding to the first epidermal growth factor homology domain of human protein C. (1996) (6)
Role of the Hexapeptide Disulfide Loop in the γ-Carboxyglutamic Acid Domain of Protein C in Ca2+-Mediated Structural and Functional Properties† (2005) (6)
Adsorption of vitamin K-dependent blood coagulation proteins to spread phospholipid monolayers as determined from combined measurements of the surface pressure and surface protein concentration. (1998) (6)
Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM). (2010) (5)
The vitronectin‐binding domain of plasminogen activator inhibitor‐1 plays an important functional role in lipopolysaccharide‐induced lethality in mice (2012) (5)
Cloning and characterization of a cDNA encoding murine coagulation factor X. (1998) (5)
Kinetic properties of bovine blood coagulation factors IXa alpha and IXa beta toward synthetic substrates. (1983) (5)
The Functions of the First Epidermal Growth Factor Homology Region of Human Protein C as Revealed by a Charge-to-Alanine Scanning Mutagenesis Investigation (1997) (5)
Hydroxyproline-induced Helical Disruption in Conantokin Rl-B Affects Subunit-selective Antagonistic Activities toward Ion Channels of N-Methyl-d-aspartate Receptors* (2015) (5)
Circular dichroism analysis of the secondary structures of bovine blood coagulation factor IX, factor X, and prothrombin (1988) (5)
Functional and structural consequences of aromatic residue substitutions within the kringle-2 domain of tissue-type plasminogen activator. (1999) (5)
Protective Effect of Activated Protein C in Murine Endotoxemia: Mechanism of Action. (2005) (5)
Chromosomal arrangement of the murine coagulation factor VII and factor X genes. (1998) (5)
Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin. (1993) (5)
Binding and orientation of conantokins in PL vesicles and aligned PL multilayers. (2003) (4)
Plasminogen and Streptokinase (2001) (4)
Transfer of specific endothelial cell-binding properties from the procoagulant protein human factor IX into the anticoagulant protein human protein C. (1995) (4)
Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes. (2019) (4)
Topographical relationships between the monovalent and divalent cation binding sites of des-1-41-light chain bovine plasma protein C and des-1-41-light chain-activated bovine plasma protein C. (1987) (4)
Low levels of tissue factor rescue protein C‐associated pregnancy failure in mice (2008) (4)
The Streptococcal Protease SpeB Antagonizes the Biofilms of the Human Pathogen Staphylococcus aureus USA300 through Cleavage of the Staphylococcal SdrC Protein (2020) (4)
Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia (2018) (4)
Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd2+/Mg2+–con-T[K7γ] complex (2010) (4)
Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons (2014) (4)
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. (2020) (4)
The M Protein of Streptococcus pyogenes Strain AP53 Retains Cell Surface Functional Plasminogen Binding after Inactivation of the Sortase A Gene (2020) (4)
Antagonist Properties of Conus parius Peptides on N-Methyl-D-Aspartate Receptors and Their Effects on CREB Signaling (2013) (4)
Calorimetric study of the rabbit hepatic galactoside binding protein: effects of calcium and ligands. (1981) (4)
The effector roles of kringle 1 and kringle 2 in the enzymatic properties of recombinant tissue-type plasminogen activator as revealed by generation of recombinant molecules containing each kringle linked to the protease domain. (1993) (4)
Fibrinogen facilitates the anti-tumor effect of nonnative endostatin. (2009) (4)
In situ metabolite and lipid analysis of GluN2D−/− and wild-type mice after ischemic stroke using MALDI MSI (2020) (4)
Complex formation of human Val354-plasminogen with streptokinase. (1983) (4)
gamma-Glutamate and beta-hydroxyaspartate in proteins. (2008) (4)
The construction and expression of chimeric urokinase-type plasminogen activator genes containing kringle domains of human plasminogen. (1993) (4)
Plasminogen Activator Inhibitor-1 Urokinase-Type Plasminogen Activator or Its Inhibitor , Tumor Development Is Retarded in Mice Lacking the Gene for Updated (2000) (3)
Binding of calcium to synthetic peptides containing γ-carboxyglutamic acid (2009) (3)
The hemostasis system in murine atherosclerosis. (2008) (3)
Isolation of a low molecular weight form of plasminogen. (1975) (3)
A kinetic characterization of the rabbit plasmin isozymes. (1976) (3)
Evaluation of the thrombospondin-1 analogue ABT-510 in the APCMin/+ mouse intestinal adenoma model. (2006) (3)
Comparative studies of the physical state of the lipid phase of normal and hypercholesterolemic very low density lipoprotein. (1979) (3)
Secondary structure predictions of human plasminogen and the bovine prothrombin kringle loops. (1986) (3)
The crystal structure of the calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer (2010) (3)
AFFINITY CHROMATOGRAPHY RESOLUTION OF PLASMINOGEN ISOZYMES (1975) (3)
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier (2021) (2)
The effect of calcium on the thermotropic properties of bovine blood coagulation factors IX and X and their activation intermediates and products. (1983) (2)
A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen. (2020) (2)
Tissue Distribution of Fetal Liver Cells Following in Utero Transplantation in Mice (2005) (2)
Fas Ligand Expression and Its Correlation with Apoptosis and Proliferation in Lobund-Wistar Prostate Carcinomas (2005) (2)
Inhibition of opsonization by Streptococcus pyogenes 1 Streptococcus pyogenes Employs Strain-dependent Mechanisms of C 3 b Inactivation to Inhibit Phagocytosis and Killing of Bacteria (2016) (2)
ENHANCEMENT OF THE STREPTOKINASE‐INDUCED ACTIVATION OF HUMAN PLASMINOGEN BY HUMAN FIBRINOGEN AND HUMAN FIBRINOGEN FRAGMENT D1 * (1983) (2)
pathogens stimulate a proinflammatory response in vitro and in vivo Exosomes released from macrophages infected with intracellular (2007) (2)
Generation and characterization of factor X deficient mice (1998) (2)
Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence (2020) (1)
Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes. (2019) (1)
A FVII Deficiency Induces Cardiac Fibrosis in Mice Resulting in Systolic and Diastolic Dysfunction. (2007) (1)
The Role of Lys-Plasminogen in Cell-Mediated Plasmin Production (2003) (1)
A unique combination of glycoside hydrolases in Streptococcus suis specifically and sequentially acts on host-derived αGal-epitope glycans (2020) (1)
The propeptides of human protein C, factor VII, and factor IX are exchangeable with regard to directing gamma-carboxylation of these proteins. (1996) (1)
The utility of modified thromboelastography with platelet mapping and functional fibrinogen to predict bleeding during catheter-directed thrombolysis: a pilot study (2015) (1)
159 Structure and ligand binding properties of the kringle 5 domain of human plasminogen (1997) (1)
Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. (2016) (1)
Generation of an antibody with a designed specificity difference for protein C and activated protein C (1989) (1)
ID: 365 Role of the Plasminogen Activation System in Hippocampal Neuritogenesis (2006) (1)
144 Critical role of the glu-lys plasminogen transition in glu-plasminogen activation on the cell surface (1997) (1)
The Mechanism of Activation of Human Plasminogen by Urokinase (1977) (1)
Comparative pathogenomic characterization of a non‐invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers (2017) (1)
Chapter 648 – Plasmin (2013) (1)
Reductive Amination with Tritylamine as an Ammonia Equivalent: Efficient Preparation of the 5‐(4‐(((9‐Fluorenylmethyloxycarbonyl) amino)methyl)‐3,5‐dimethoxyphenoxy)val eric Acid (PAL) Handle for Peptide Synthesis. (1994) (1)
The carboxymethylation of bovine alpha-lactalbumin. (1970) (1)
Effects Of Fibrinogen, Fragment D, And Fragment E On The Streptokinase Induced Activation Of Human Plasminogen (1981) (1)
24 Expression of a human plasminogen cDNA in an insect system (1988) (1)
Expression of human anticoagulation protein C and gamma-carboxyglutamic acid mutants in mammalian cell cultures. (1997) (1)
Binding of calcium to synthetic peptides containing gamma-carboxyglutamic acid. (1993) (1)
Past and Present Behçet's Disease Animal Models. (2020) (1)
Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties. (2005) (1)
Platelet dysfunction as an early marker for traumatic brain induced coagulopathy in the absence of platelet inhibitors (2012) (1)
ID: 154 Plasminogen activator inhibitor 1 forms a stable non-acyl enzyme inhibitor complex with tissue plasminogen activator (2006) (1)
of FVII at levels that protect against fatal spontaneous hemorrhage AAV-mediated gene transfer in the perinatal period results in expression (2014) (1)
Prediction of the secondary structures of bovine blood coagulation factor IX, factor X, and prothrombin (1988) (1)
Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes (2018) (1)
gamma-glutamate and beta-hydroxyaspartate in proteins. (2002) (1)
Effect of Sulindac Sulfide on Metallohydrolases in the Human Colon Cancer Cell Line HT-29 (2011) (1)
Estimation of the distance between the divalent cation binding site of des-1-41-light chain-activated bovine plasma protein C and a nitroxide spin label attached to the active-site serine residue. (1988) (1)
Fibrin is a critical regulator of neutrophil effector function at mucosal barrier sites (2021) (1)
ID: 231 The role of fibrinogen in a murine model of lethal endotoxemia (2006) (0)
323 A role for chloride ion and fibrinogen in the activation of [GLU1]plasminogen in human plasma (1988) (0)
Solution structure of VEK50 (2020) (0)
A PROBE OF THE HUMAN PLASMIN‐α2‐MACROGLOBULIN INTERACTION UTILIZING MONOCLONAL ANTIBODIES TO HUMAN PLASMIN a (1983) (0)
A total fibrinogen deficiency is compatible with the development of bleomycininduced pulmonary fibrosis in mice (2000) (0)
Duties and Powers The Academic Council • Authorizes establishment or discontinuance ' of academic organizations • Considers recommendations of Graduate Council • Sets academic policy • Approves major changes in admissions requirements Council to deliberate issues of harrassment , academics (0)
176 Structure-function consequences of mutations of aromatic residues of the kringle 2 domain of tissue-type plasminogen activator (1997) (0)
Discovery of genes encoding a Streptolysin S-like toxin biosynthetic cluster in a select highly pathogenic methicillin resistant Staphylococcus aureus JKD6159 strain (2019) (0)
Solution structure of KTI55-Kringle 2 complex (2020) (0)
kininogen and delays thrombosis ) causes loss of plasma mKng1 Deletion of murine kininogen gene 1 ( (2008) (0)
Corrections - Interaction of Calcium with Bovine Plasma Protein C (1981) (0)
severe protein C deficiency Acute inflammation is exacerbated in mice genetically predisposed to a (2013) (0)
kininogen and delays thrombosis Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma (2013) (0)
SOLUTION STRUCTURE OF THE COMPLEX OF MUTANT VEK50[RH1/AA] AND PLASMINOGEN KRINGLE 2 (2019) (0)
Biologics as a Platform for Inflammation Therapies (2014) (0)
Abstract 836: Coagulation Factor VII Contributes to Lethal Endotoxemia in Mice in Association with Regulation of Egr-1 (2006) (0)
Solution structure of VEK75 (2019) (0)
Synthetic conantokin peptides potently inhibit NMDA receptor-mediated currents of retinal ganglion cells (2013) (0)
ID: 254 Protein C at the Crossroads of Coagulation and Inflammation (2006) (0)
Solution structure of truncated peptide from PAMap53 (2020) (0)
Fundamental and clinical fibrinolysis : proceedings of the International Conference on Fibrinolysis, Hamamatsu, Japan, September 27-29, 1986 (1987) (0)
Plasminogen-Directed Phenotypes in Mice (2003) (0)
A probe of the human plasmin-alpha 2-macroglobulin interaction utilizing monoclonal antibodies to human plasmin. (1983) (0)
List of Authors and Speakers (1988) (0)
The human plasminogen amino acid variants encoding nukleiinihappos ekvenssi, an expression vector containing it and a host cell, as well as to method a plasminogen amino acid variant of the preparation and the method for forming two fibrinolytic oiskompleksin (1990) (0)
Demonstration of three distinct high molecular weight complexes between plasminogen activator inhibitor type 1 and tissue type plasminogen activator. (2021) (0)
Evolution of Gram+ Streptococcus pyogenes has maximized efficiency of the Sortase A cleavage site (2021) (0)
Topographical relationships among the monovalent cation binding sites of bovine plasma-activated protein C and des(1–41)-light-chain-activated bovine plasma protein C and a nitroxide spin label bound to their active site serine residues (1987) (0)
Corrections - Interaction of Streptokinase and Rabbit Plasminogen (1973) (0)
246 Effectors of the activation of human [GLU1] plasminogen by recombinant tissue plasminogen activator (1988) (0)
Solution structure of AGL55 (2019) (0)
Title Page / Table of Contents, Vol. 18, Supplement 1, 1988 (1988) (0)
Solution structure of KTI55 (2019) (0)
Recombinant Human Activated Protein C Suppresses Endotoxin Induced Hypotension in Mice Deficient of the Endothelial Protein C Receptor (EPCR). (2005) (0)
Mono clonal antibodies as probes of the alpha 2 macro globulin plasmin interaction (1983) (0)
Acknowledgement of Reviewers (2009) (0)
The activation and inhibition of fibrinolysis. (1975) (0)
Ca2+ Binding properties of synthetic γ-carboxyglutamic acid containing peptides homologous to protein C (1994) (0)
Stable genetic integration of a red fluorescent protein in a virulent Group A Streptococcus strain (2019) (0)
Host Pathways of Hemostasis that Regulate Group A Streptococcus Pyogenes Pathogenicity. (2019) (0)
The Solution Structure of the Magnesium-bound Conantokin-R1B Mutant (2017) (0)
ID: 291 Fibrinogen deficiency and LDL driven atherosclerosis in mice (2006) (0)
Performance of Murine Soluble Thrombomodulin (rmsTM) in a Murine Model of Endotoxin-Induced Sepsis. (2006) (0)
Binding of the kringle‐2 domain of human plasminogen to streptococcal PAM‐type M‐protein causes dissociation of PAM dimers (2021) (0)
hPg. PAM is covalently bound to the cell wall (CW) through cell membrane (CM)-resident 24 sortase A (SrtA)-catalyzed cleavage of the PAM-proximal C-terminal LPST (2021) (0)
Solution structure of AGL55-Kringle 2 complex (2020) (0)
Challenge with LPS or TNF-α Demonstrates Unique Differences in Primary Arterial Endothelial Cells Pretreated with Recombinant Human Activated Protein C. (2004) (0)
Challenge with LPS or TNF-α Demonstrates Unique Differences in Primary Arterial Endothelial Cells Pretreated with Recombinant Human Activated Protein C. (2004) (0)
Mono clonal antibodies to human plasminogen (1982) (0)
The X-ray Structure of Human Angiostatin (2002) (0)
That Induce Hypervirulence Streptococcus pyogenes Identify Genes Invasive Serotype M 23 Strain of Unique Genomic Arrangements in an (2014) (0)
High levels of LDL‐cholesterol rescue the neonatal mortality associated with afibrinogenemia in mice (2007) (0)
Solution structure of VKK38 bound to plasminogen kringle 2 (2017) (0)
lipopolysaccharide-induced endotoxemia in the mouse A cardioprotective role for the endothelial protein C receptor in (2013) (0)
ID: 298 The Effects of a PAM-derived Peptide on the Structure and Zymogenicity of Plasminogen (2006) (0)
Conscription of the host fibrinolytic system as a virulence determinant for Streptococcus pyogenes (2016) (0)
Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. (2019) (0)
Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution (2021) (0)
Rapid formation of an anion-sensitive active site in stoichiometric complexes of streptokinase and human [ Glu 1 ] plasminogen ( plasminogen activation / plasminogen-streptokinase interactions / plasminogen activator complexes / ionic inhibition of plasminogen activators ) (0)
Plasminogen Activator Inhibitor 1 Deficiency Reduces the Progression of Atherosclerosis in a Murine Model of Human Familial Hypercholesterolemia. (2006) (0)
Generation of mice with mutagenized u-pa genes, via the cre/lox recombination strategy (1996) (0)
Short Communication A Total Fibrinogen Deficiency Is Compatible with the Development of Pulmonary Fibrosis in Mice (2000) (0)
The solution structure of the Magnesium-bound Conantokin RLB (2015) (0)
S1637 Unexpected Role of Coagulative Protein in Controlling Epithelial Barrier Integrity and Intestinal Inflammation (2009) (0)
ANIONIC INHIBITION OF PLASMINOGEN ACTIVATION (1987) (0)
THROMBOSIS AND HEMOSTASIS A CCR 2 macrophage endocytic pathway mediates extravascular fi brin clearance in vivo (2016) (0)
Plasminogen Deficiency Significantly Reduces Vascular Wall Disease in a Murine Model of Type IIa Hypercholesterolemia (2021) (0)
Interactions of the bacterial and host systems in the persistence of group A-Streptoccal infections in humans (2016) (0)
UvA-DARE ( Digital Academic Repository ) Factor XI as target for antithrombotic therapy (2014) (0)
Science Foerfarande material Foer expression of a human plasminogenvariant. (1990) (0)
Remote Multisensing of Biological Systems (2002) (0)
Foam cell formation is regulated by plasmin in a murine model of type IIa hypercholesterolemia (2019) (0)
111 Inhibitors for proteases involved in blood coagulation and fibrinolysis from streptomyces griseus (1988) (0)
Solution structure of VEK50 in the bound form with plasminogen kringle 2 (2019) (0)
Review was balanced (1979) (0)
Interactions between Streptococcus pyogenes and the host innate immune system that promote bacterial virulence (2016) (0)
The Protective Role of Protein C in Endotoxin-Induced Shock. (2007) (0)
100 The enhancement by various fibrinogen/fibrin domains of the activation of human plasminogen by tissue plasminogen activator (1988) (0)
Monoclonal Antibodies Detect Receptor-Induced Binding Sites (RIBS) (2011) (0)
Molecular Medicine II: Hormone Dependent Cancers (2005) (0)
W1609 The Anticoagulant Protein C System Is Expressed and Functionally Active in Mucosal Dendritic and Epithelial Cells and Is Down-Regulated in IBD Patients (2009) (0)
SOLUTION STRUCTURE OF THE COMPLEX OF MUTANT VEK50[RH2/AA] AND PLASMINOGEN KRINGLE 2 (2019) (0)
A Factor VII Deficiency Protects Against Lethal Endotoxemia in Mice. (2004) (0)
Solution structure of VEK50RH1/AA (2020) (0)
Use of phospholipid bilayers and monolayers in binding studies of vitamin K-dependent blood coagulation proteins. (2002) (0)

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What Schools Are Affiliated With Francis J Castellino?

Francis J Castellino is affiliated with the following schools:

University of Notre Dame
University of Scranton
University of Iowa