Francis V. Chisari | Academic Influence

Francis V. Chisari's AcademicInfluence.com Rankings

Francis V. Chisari

Biology

#4539

World Rank

#6758

Historical Rank

#1688

USA Rank

Virology

#88

World Rank

#91

Historical Rank

#31

USA Rank

Microbiology

#181

World Rank

#212

Historical Rank

#67

USA Rank

biology Degrees

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Biology

Francis V. Chisari's Degrees

PhD Virology University of California, Berkeley
Masters Microbiology University of California, Berkeley
Bachelors Biology University of California, Berkeley

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Why Is Francis V. Chisari Influential?

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According to Wikipedia, Francis "Frank" Vincent Chisari is a physician, experimental pathologist, virologist, and immunologist, known for his research on virus-host interactions of hepatitis B and hepatitis C. Education and career Chisari graduated in 1963 with a bachelor's degree in biology from Fordham University and in 1968 with an M.D. from Cornell University's Weill Medical College. He was in 1970 and 1971 a fellow in anatomic pathology at the Mayo Clinic and in 1972 a staff associate in immunopathology at the NIH's Laboratory of Pathology. In 1973 he completed his residency in internal medicine at Dartmouth Medical School. At Scripps Research he became a research fellow, then an assistant professor from 1975 to 1981, an associate professor from 1981 to 1988, and a full professor from 1988 to 2015, retiring as professor emeritus in 2015. At Scripps Research he headed the Division of Experimental Pathology from 1988 to 2008 and the Laboratory of Experimental Virology from 2008 to 2015. From 1983 to 1984 he was a Fogarty Scholar in molecular biology at the Institut Pasteur. He is now a scientific advisor for Ionis Pharmaceuticals and for Vir Biotechnology.

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Francis V. Chisari's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guidelines for the use and interpretation of assays for monitoring autophagy (2012) (6925)
Robust hepatitis C virus infection in vitro. (2005) (1828)
Hepatitis B virus immunopathogenesis. (1995) (1627)
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection (2001) (1261)
Viral clearance without destruction of infected cells during acute HBV infection. (1999) (1233)
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. (1996) (1151)
Noncytolytic control of viral infections by the innate and adaptive immune response. (2001) (1046)
Interferon modulation of cellular microRNAs as an antiviral mechanism (2007) (898)
The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. (1994) (891)
CD8+ T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection (2003) (889)
Genomic analysis of the host response to hepatitis C virus infection (2002) (846)
The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T–lymphocyte response (1996) (815)
Immunobiology and pathogenesis of viral hepatitis. (2006) (746)
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease (2002) (693)
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice (1989) (681)
Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo (2000) (623)
High-level hepatitis B virus replication in transgenic mice (1995) (614)
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge (2008) (594)
Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells (1994) (565)
Genomic analysis of the host response to hepatitis B virus infection. (2004) (557)
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids. (2005) (516)
The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis (1995) (500)
Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion (2007) (481)
Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis (1993) (468)
Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence (1999) (463)
Lambda Interferon Inhibits Hepatitis B and C Virus Replication (2005) (460)
The autophagy machinery is required to initiate hepatitis C virus replication (2009) (449)
Stealth and Cunning: Hepatitis B and Hepatitis C Viruses (2005) (431)
Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. (2012) (426)
Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. (1994) (422)
Toll-Like Receptor Signaling Inhibits Hepatitis B Virus Replication In Vivo (2005) (417)
Interference of hepatitis C virus RNA replication by short interfering RNAs (2003) (407)
Cytotoxic T cells and viral hepatitis. (1997) (395)
Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen (1991) (379)
Immune Pathogenesis of Hepatocellular Carcinoma (1998) (379)
Differential CD4+ and CD8+ T‐cell responsiveness in hepatitis C virus infection (2001) (364)
Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. (1995) (363)
Hydrodynamic injection of viral DNA: A mouse model of acute hepatitis B virus infection (2002) (361)
Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. (1997) (359)
HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. (1993) (348)
Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. (1990) (347)
Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice. (1987) (346)
Hepatitis B virus persistence after recovery from acute viral hepatitis. (1994) (344)
Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans. (1995) (338)
Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. (2010) (335)
Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. (1996) (317)
Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. (1994) (313)
HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen. (1991) (312)
Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen. (1985) (312)
Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. (1996) (308)
Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B. (2000) (306)
Long-lasting memory T cell responses following self-limited acute hepatitis B. (1996) (305)
To kill or to cure: options in host defense against viral infection. (1996) (295)
Initiation of Hepatitis C Virus Infection Is Dependent on Cholesterol and Cooperativity between CD81 and Scavenger Receptor B Type I (2006) (291)
Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients (1996) (283)
Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR (1995) (283)
The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection (2009) (279)
Relative Sensitivity of Hepatitis B Virus and Other Hepatotropic Viruses to the Antiviral Effects of Cytokines (2000) (278)
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B (2012) (278)
A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. (1985) (274)
Platelets mediate cytotoxic T lymphocyte–induced liver damage (2005) (273)
Plasmacytoid dendritic cells sense hepatitis C virus–infected cells, produce interferon, and inhibit infection (2010) (263)
Persistent Hepatitis C Virus Infection In Vitro: Coevolution of Virus andHost (2006) (261)
Differential Biophysical Properties of Infectious Intracellular and Secreted Hepatitis C Virus Particles (2006) (261)
Interleukin-12 inhibits hepatitis B virus replication in transgenic mice (1997) (255)
A global scientific strategy to cure hepatitis B. (2019) (253)
Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications (2005) (250)
Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice (1986) (247)
A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen. (2004) (245)
Intrahepatic Induction of Alpha/Beta Interferon Eliminates Viral RNA-Containing Capsids in Hepatitis B Virus Transgenic Mice (2000) (243)
Immunosurveillance of the Liver by Intravascular Effector CD8+ T Cells (2015) (240)
Blocking Chemokine Responsive to γ–2/Interferon (IFN)-γ Inducible Protein and Monokine Induced by IFN-γ Activity In Vivo Reduces the Pathogenetic but not the Antiviral Potential of Hepatitis B Virus–specific Cytotoxic T Lymphocytes (2001) (240)
Unscrambling hepatitis C virus–host interactions (2005) (239)
Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope (1994) (233)
Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. (1991) (230)
Transmission of type B viral hepatitis to chimpanzees. (1973) (223)
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation. (2009) (223)
Immune effectors required for hepatitis B virus clearance (2009) (222)
HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis (1993) (221)
Immune Tolerance Split between Hepatitis B Virus Precore and Core Proteins (2005) (214)
Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees (2004) (213)
Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. (1996) (210)
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice (2002) (207)
PD-1:PD-L1 Interactions Contribute to the Functional Suppression of Virus-Specific CD8+ T Lymphocytes in the Liver1 (2007) (205)
Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. (2005) (203)
Ultrastructural and Biophysical Characterization of Hepatitis C Virus Particles Produced in Cell Culture (2010) (203)
Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice (1995) (201)
Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo. (1994) (200)
Oscillating CD8(+) T cell effector functions after antigen recognition in the liver. (2005) (197)
Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. (1990) (195)
Hepatitis B virus transgenic mice: Insights into the virus and the disease (1995) (186)
Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis. (1997) (184)
Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein (1993) (180)
Interleukin-18 Inhibits Hepatitis B Virus Replication in the Livers of Transgenic Mice (2002) (174)
Pathogenesis of hepatitis B virus infection. (2010) (171)
Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees. (2000) (171)
Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver (2014) (171)
Viruses and the autophagy machinery (2010) (170)
Immune response to the pre-S(1) region of the hepatitis B surface antigen (HBsAg): a pre-S(1)-specific T cell response can bypass nonresponsiveness to the pre-S(2) and S regions of HBsAg. (1986) (168)
Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids. (2005) (164)
Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells (2007) (163)
Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B. (1987) (160)
Cytokine-mediated control of viral infections. (2000) (158)
Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice. (1998) (158)
Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences (1987) (156)
DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice. (1996) (151)
Noncytopathic Clearance of Lymphocytic Choriomeningitis Virus from the Hepatocyte (1999) (151)
Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. (1991) (148)
The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection. (1997) (147)
Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice (1992) (144)
Inhibition of Hepatitis B Virus Replication during Adenovirus and Cytomegalovirus Infections in Transgenic Mice (1998) (143)
Hepatitis B virus transgenic mice: models of viral immunobiology and pathogenesis. (1996) (142)
Dynamics of hepatitis B virus clearance in chimpanzees. (2005) (142)
Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways (1994) (141)
Native hepatitis B virions and capsids visualized by electron cryomicroscopy. (2006) (140)
HBsAg retention sensitizes the hepatocyte to injury by physiological concentrations of interferon‐γ (1992) (140)
T cell response in hepatitis C virus infection. (2005) (138)
MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. (2004) (135)
Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans. (1999) (134)
Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth. (1992) (133)
CTL access to tissue antigen is restricted in vivo. (1994) (132)
Cell mediated immune response to the hepatitis C virus. (2000) (130)
Cytokine-Sensitive Replication of Hepatitis B Virus in Immortalized Mouse Hepatocyte Cultures (2002) (130)
Immunogenicity and Tolerogenicity of Hepatitis B Virus Structural and Nonstructural Proteins: Implications for Immunotherapy of Persistent Viral Infections (2002) (130)
Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C. (1999) (129)
A virocidal amphipathic α-helical peptide that inhibits hepatitis C virus infection in vitro (2008) (128)
Immunological aspects of hepatitis B virus infection. (1975) (128)
Nitric Oxide Inhibits Hepatitis B Virus Replication in the Livers of Transgenic Mice (2000) (127)
Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes. (1995) (124)
CD40 Activation Rescues Antiviral CD8+ T Cells from PD-1-Mediated Exhaustion (2013) (124)
Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms. (2006) (120)
The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice (1996) (120)
Activated Intrahepatic Antigen-Presenting Cells Inhibit Hepatitis B Virus Replication in the Liver of Transgenic Mice1 (2002) (119)
Host-virus interactions in hepatitis B virus infection. (2015) (119)
Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice (2002) (119)
HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. (2010) (118)
Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). I. H-2 restriction of the murine humoral immune response to the a and d determinants of HBsAg. (1982) (118)
Hepatitis B virus immunopathology (2004) (118)
Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice. (1997) (116)
Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection. (1995) (116)
Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice (1995) (116)
Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes (2002) (115)
The optimization of helper T lymphocyte (HTL) function in vaccine development (1998) (111)
Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic mice (1994) (111)
Platelets prevent IFN-α/β-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus (2008) (110)
Lymphocyte E rosette inhibitory factor: a regulatory serum lipoprotein (1975) (110)
Differential target cell sensitivity to CTL-activated death pathways in hepatitis B virus transgenic mice. (1997) (109)
Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection (2009) (109)
Searching for Interferon-Induced Genes That Inhibit Hepatitis B Virus Replication in Transgenic Mouse Hepatocytes (2003) (108)
Cutting Edge: Inhibition of Hepatitis B Virus Replication by Activated NK T Cells Does Not Require Inflammatory Cell Recruitment to the Liver1 (2001) (108)
Kupffer Cells Hasten Resolution of Liver Immunopathology in Mouse Models of Viral Hepatitis (2011) (107)
Hepatitis C Virus (HCV) Induces Formation of Stress Granules Whose Proteins Regulate HCV RNA Replication and Virus Assembly and Egress (2012) (106)
Induction of specific cytochrome P450s involved in aflatoxin B1 metabolism in hepatitis B virus transgenic mice (1994) (106)
Distinct H-2-linked regulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows circumvention of nonresponsiveness to the S region. (1985) (105)
PD-1:PD-L1 Interactions Contribute to the Functional Suppression of Virus-Specific CD8 T Lymphocytes in the Liver (2007) (105)
Replication of a hepatitis C virus replicon clone in mouse cells (2006) (104)
Hepatitis B small surface antigen particles are octahedral. (2005) (104)
Production of Infectious Hepatitis C Virus by Well-Differentiated, Growth-Arrested Human Hepatoma-Derived Cells (2006) (103)
Immunology and the liver (1991) (103)
Human Transporters Associated with Antigen Processing (Taps) Select Epitope Precursor Peptides for Processing in the Endoplasmic Reticulum and Presentation to T Cells (1999) (100)
Hepatitis B Virus RNA-Binding Proteins Associated with Cytokine-Induced Clearance of Viral RNA from the Liver of Transgenic Mice (1999) (99)
Break of T Cell Ignorance to a Viral Antigen in the Liver Induces Hepatitis (2000) (96)
Functional characterization of cloned intrahepatic, hepatitis B virus nucleoprotein-specific helper T cell lines. (1987) (94)
Virion-Independent Transfer of Replication-Competent Hepatitis C Virus RNA between Permissive Cells (2014) (94)
Previously Infected Chimpanzees Are Not Consistently Protected against Reinfection or Persistent Infection after Reexposure to the Identical Hepatitis C Virus Strain (2008) (92)
La Autoantigen Specifically Recognizes a Predicted Stem-Loop in Hepatitis B Virus RNA (1999) (88)
Polyclonality and multispecificity of the CTL response to a single viral epitope. (1998) (88)
DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb- and Kd-restricted epitopes. (1997) (88)
Overcoming T Cell Tolerance to the Hepatitis B Virus Surface Antigen in Hepatitis B Virus-Transgenic Mice1 (2001) (87)
Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas (1990) (87)
Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice. (1995) (87)
Human class I supertypes and CTL repertoires extend to chimpanzees. (1998) (86)
Recombinant Duck Interferon Gamma Inhibits Duck Hepatitis B Virus Replication in Primary Hepatocytes (1999) (85)
Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes. (1997) (85)
Inhibition of Hepatitis B Virus Replication by Interferon Requires Proteasome Activity† (2002) (85)
Hepatitis B virus structure and biology. (1989) (85)
Expression of the hepatitis delta virus large and small antigens in transgenic mice (1994) (80)
Cytokine-induced viral purging--role in viral pathogenesis. (1999) (78)
Immunoregulatory properties of human plasma in very low density lipoproteins. (1977) (77)
Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome. (1996) (76)
Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus (2008) (75)
Protein transfer of preformed MHC-peptide complexes sensitizes target cells to T cell cytolysis. (1994) (74)
Nonoverlapping T and B cell determinants on an hepatitis B surface antigen pre-S(2) region synthetic peptide (1986) (74)
Transcriptional and posttranscriptional control of hepatitis B virus gene expression (2003) (72)
Interleukin-2 downregulates hepatitis B virus gene expression in transgenic mice by a posttranscriptional mechanism (1993) (72)
Signal transduction pathways that inhibit hepatitis B virus replication. (2004) (69)
Host–Virus Interactions during Malaria Infection in Hepatitis B Virus Transgenic Mice (2000) (69)
Hepatitis B virus (HBV)-specific cytotoxic T-cell response in humans: production of target cells by stable expression of HBV-encoded proteins in immortalized human B-cell lines (1992) (66)
Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). IV. Distinct H-2-linked Ir genes control antibody responses to different HBsAg determinants on the same molecule and map to the I-A and I-C subregions (1984) (65)
Multiple oncogenes and tumor suppressor genes are structurally and functionally intact during hepatocarcinogenesis in hepatitis B virus transgenic mice. (1992) (65)
Hepatic preneoplasia in hepatitis B virus transgenic mice (1994) (65)
Autophagy proteins promote hepatitis C virus replication (2009) (63)
Cellular and molecular mechanisms of hepatocarcinogenesis. (1992) (63)
A research agenda for curing chronic hepatitis B virus infection (2018) (61)
Foodborne outbreak of hepatitis A: clinical and laboratory features of acute and protracted illness (1979) (61)
Characterization of Nuclear RNases That Cleave Hepatitis B Virus RNA near the La Protein Binding Site (2001) (60)
Viral mutations, TCR antagonism and escape from the immune response. (1995) (59)
Impact of the Autophagy Machinery on Hepatitis C Virus Infection (2011) (58)
Elimination of Duck Hepatitis B Virus RNA-Containing Capsids in Duck Interferon-Alpha-Treated Hepatocytes (1999) (57)
Induction in vitro of a primary human antiviral cytotoxic T cell response (1995) (55)
Immunopathology of hepatitis C (2004) (55)
Platelets Mediate Cytotoxic T Lymphocyte-Induced Liver Damage. (2005) (54)
Ocular reticulum cell sarcoma. Presentation as retinal detachment with demonstration of monoclonal immunoglobulin light chains on the vitreous cells. (1981) (54)
Advances in hepatitis research (1984) (53)
Immunological aspects of HCV infection. (1994) (53)
Mechanisms responsible for defective human T-lymphocyte sheep erythrocyte rosette function associated with hepatitis B virus infections. (1976) (52)
Hepatitis B virus (HBV)-specific cytotoxic T-cell (CTL) response in humans: characterization of HLA class II-restricted CTLs that recognize endogenously synthesized HBV envelope antigens (1992) (52)
In Vivo Study of the HC-TN Strain of Hepatitis C Virus Recovered from a Patient with Fulminant Hepatitis: RNA Transcripts of a Molecular Clone (pHC-TN) Are Infectious in Chimpanzees but Not in Huh7.5 Cells (2007) (51)
In vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides. (1995) (50)
Ongoing Murine T1 or T2 Immune Responses to the Hepatitis B Surface Antigen Are Excluded from the Liver that Expresses Transgene-Encoded Hepatitis B Surface Antigen1 (2000) (48)
Regulation of human lymphocyte function by a soluble extract from normal human liver. (1978) (48)
Functional properties of lymphocyte subpopulations in hepatitis B virus infection. II. Cytotoxic effector cell killing of targets that naturally express hepatitis B surface antigen and liver-specific lipoprotein. (1981) (45)
Functional properties of lymphocyte subpopulations in hepatitis B virus infection. I. Suppressor cell control of T lymphocyte responsiveness. (1981) (45)
Inhibition of Hepatitis B Virus Replication during Schistosoma mansoni Infection in Transgenic Mice (2000) (44)
Two distinct but overlapping antibody binding sites in the pre-S(2) region of HBsAg localized within 11 continuous residues. (1986) (44)
Selective sensitization of peripheral blood T lymphocytes to hepatitis B core antigen in patients with chronic active hepatitis type B. (1986) (43)
Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus. (2011) (43)
Hepatitis B virus biology and pathogenesis. (1992) (41)
Extrinsic modulation of human T-lymphocyte E rosette function associated with prolonged hepatocellular injury after viral hepatitis. (1977) (41)
Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice. (1992) (41)
Role of Immunoproteasome Catalytic Subunits in the Immune Response to Hepatitis B Virus (2006) (41)
Sigma-1 Receptor Regulates Early Steps of Viral RNA Replication at the Onset of Hepatitis C Virus Infection (2013) (40)
Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology (2017) (40)
Altered expression of hepatic carcinogen metabolizing enzymes with liver injury in HBV transgenic mouse lineages expressing various amounts of hepatitis B surface antigen. (1999) (40)
Pathogenic role of B cells in anti-CD40-induced necroinflammatory liver disease. (2006) (39)
Targeting Murine Immune Responses to Selected T Cell- or Antibody-Defined Determinants of the Hepatitis B Surface Antigen by Plasmid DNA Vaccines Encoding Chimeric Antigen1 (2001) (39)
Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). II. Qualitative characteristics of the humoral immune response to the a, d, and y determinants of HBsAg. (1983) (39)
Synergy between transforming growth factor alpha and hepatitis B virus surface antigen in hepatocellular proliferation and carcinogenesis. (1997) (38)
Comment on “Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA” (2014) (38)
Reversibility of hepatitis B virus-induced glomerulonephritis and chronic active hepatitis after spontaneous clearance of serum hepatitis B surface antigen. (1978) (35)
Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). VI. T cell fine specificity. (1985) (35)
The modulating effect of cholera enterotoxin on the immune response. (1974) (34)
Identification of Five Different Patr Class I Molecules That Bind HLA Supertype Peptides and Definition of Their Peptide Binding Motifs1 (2000) (34)
Response of monkeys to immunization with cholera toxoid, toxin, and vaccine: reversion of cholera toxoid. (1972) (34)
Limited Hepatitis B Virus Replication Space in the Chronically Hepatitis C Virus-Infected Liver (2014) (34)
Degenerate Immunogenicity of an HLA-A2-Restricted Hepatitis B Virus Nucleocapsid Cytotoxic T-Lymphocyte Epitope That Is Also Presented by HLA-B51 (2001) (34)
The Hepatitis B Virus X Protein Transactivates Viral Core Gene Expression In Vivo (1999) (33)
Hepatitis B virus replication is cell cycle independent during liver regeneration in transgenic mice (1997) (33)
Human Plasmacytoid Dendritic Cells Sense Lymphocytic Choriomeningitis Virus-Infected Cells In Vitro (2013) (33)
Immunoregulatory properties of human esophageal tumor extract. (1979) (32)
The class I-restricted cytotoxic T lymphocyte response to predetermined epitopes in the hepatitis B and C viruses. (1994) (31)
Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant hepatitis (1996) (31)
Glycylprolyl-diaminopeptidase in human leukocytes: selective occurrence in T lymphocytes and influence on the total serum enzyme activity. (1984) (30)
Repression of hepatitis B virus (HBV) transgene and HBV-induced liver injury by low protein diet (1997) (30)
Roentgenographic classification of renal cystic disease. (1968) (30)
Endothelial and pit cells (2001) (28)
Physiologic concentrations of normal human plasma lipoproteins inhibit the immortalization of peripheral B lymphocytes by the Epstein-Barr virus. (1981) (28)
Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). III. Circumvention of nonresponsiveness in mice bearing HBsAg nonresponder haplotypes. (1983) (28)
Differential dynamics of the peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B surface antigen. (2005) (27)
Detailed characterization of the peptide binding specificity of five common Patr class I MHC molecules (2006) (27)
Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). V. T cell proliferative response and cellular interactions. (1985) (27)
Recognition of a novel naturally processed, A2 restricted, HCV-NS4 epitope triggers IFN-gamma release in absence of detectable cytopathicity. (1998) (26)
Bortezomib Inhibits Hepatitis B Virus Replication in Transgenic Mice (2009) (25)
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection (2020) (25)
Characterization of the peptide-binding specificity of the chimpanzee class I alleles A*0301 and A*0401 using a combinatorial peptide library (2007) (24)
An Integrated Transcriptomic and Meta-Analysis of Hepatoma Cells Reveals Factors That Influence Susceptibility to HCV Infection (2011) (23)
Liver-specific protein in perspective (1980) (23)
Nucleic acid vaccination primes hepatitis B (1995) (22)
Pathophysiologic effects of lethal and immunoregulatory doses of cholera enterotoxin in the mouse. (1974) (22)
Subretinal neovascular membrane and disciform scar in Behçet's disease. (1980) (20)
Heterotransplantation of two human lymphoid cell lines transformed in vitro by Epstein-Barr virus. (1971) (19)
Minisatellite rearrangements are increased in liver tumours induced by transplacental aflatoxin B1 treatment of hepatitis B virus transgenic mice, but not in spontaneously arising tumours. (1997) (18)
Functional modulation of hepatitis B core antigen-specific T lymphocytes by an autoreactive T cell clone. (1988) (18)
Elevations of hepatic quinone reductase, glutathione, and alpha- and mu-class glutathione S-transferase isoforms in mice with chronic hepatitis: a compensatory response to injury. (1996) (17)
Transgenic Models of Human Viral and Immunological Disease (2013) (17)
Modulation of the in vivo immune response by human plasma very low-density lipoproteins. (1980) (17)
GB virus C and mortality from HIV infection. (2002) (16)
Intracellular Hepatitis B Virus Nucleocapsids Survive Cytotoxic T-Lymphocyte-Induced Apoptosis (2000) (16)
Behçet's disease. (1982) (16)
Recovery of soluble sheep erythrocyte receptor from the T lymphocyte surface by proteolytic cleavage. (1977) (16)
Antibodies to oral mucosa in patients with ocular Behcet's disease. (1985) (14)
Antiviral Stilbene 1,2-Diamines Prevent Initiation of Hepatitis C Virus RNA Replication at the Outset of Infection (2011) (14)
Immunochemistry of the hepatitis B virus: 125I HB Ag ligand. (1974) (14)
Fine specificity of the human T cell response to hepatitis B virus core antigen. (1992) (13)
The role of the inflammatory response of skin and lymph nodes in the induction of sensitization to simple chemicals. (1973) (13)
Analysis of hepadnavirus gene expression, biology, and pathogenesis in the transgenic mouse. (1991) (13)
Suppression of Lymphocyte Activation by a Protein Released from Isolated Perfused Rat Liver (2007) (12)
Parathyroid necrosis and hypocalcemic tetany induced in rabbits by L-asparaginase. (1972) (10)
Evaluation of monoclonality of cell lines from sequential dilution assays. (1987) (10)
Retroviral-mediated transfer and expression of hepatitis B e antigen in human primary skin fibroblasts and Epstein-Barr virus-transformed B lymphocytes. (1989) (10)
Is antigenic variability a strategy adopted by hepatitis B virus to escape cytotoxic T-lymphocyte surveillance? (1996) (9)
Modulation of peripheral blood mononuclear cell cyclic adenosine monophosphate levels by human very low density lipoprotein (1981) (9)
Liver-specific protein in perspective. (1980) (8)
Is Elimination of Hepatitis B and C a Pipe Dream or Reality? (2019) (7)
Laboratory tests for diagnosis of autoimmune diseases. (1975) (7)
Correction: CD40 Activation Rescues Antiviral CD8+ T Cells from PD-1-Mediated Exhaustion (2017) (6)
HLA class I restricted cytotoxic T cells in acute viral hepatitis type B (1991) (5)
Is Elimination of Hepatitis B and C a Pipe Dream or Reality? (2018) (5)
New model systems for hepatitis B virus research. (1988) (5)
Hepatitis B virus gene expression in transgenic mice. (1989) (5)
Hepatitis B virus persistence after recovery from acute viral hepatitis. (1994) (5)
Use of immunoglobulin light chain analysis to detect bone marrow involvement in B-cell neoplasms. (1982) (4)
Correction: CD40 Activation Rescues Antiviral CD8+ T Cells from PD-1-Mediated Exhaustion (2016) (4)
T Lymphocytes in the Liver + CD8Functional Suppression of Virus-Specific PD-1:PD-L1 Interactions Contribute to the (2007) (4)
Patients with Acute and Chronic Hepatitis C CTL Response to Hepatitis C Virus in Identification of HLA-A 3 and-B 7-Restricted (1998) (4)
Cholera toxoid reactions in human volunteers: clinical and histological studies. (1971) (4)
Workshop report from the Division of Research Grants, National Institutes of Health. Molecular genetic approaches to the analysis of malignant transformation--a pathology B study section workshop. (1990) (4)
GENETIC REGULATION OF THE IMMUNE RESPONSE TO HEPATITIS B SURFACE ANTIGEN (HBsAg) IV. Distinct H-2-1inked Ir Genes Control Antibody Responses to Different HBsAg Determinants on the Same Molecule and Map to the (1984) (4)
The cellular immune response to nucleocapsid antigens in hepatitis B virus infection (2004) (3)
Synthesis in cho cells of hepatitis B surface antigen containing the PRE-S2 region expression product (1985) (3)
THE IMMUNOLOGY OF CHRONIC HEPATITIS B (1998) (3)
Cellular Immune Responses to Hepatitis Viruses: Summary of a Specialty Session (1994) (3)
Intracellular Inactivation of the Hepatitis B Virus by Inflammatory Cytokines (1998) (3)
A proposed role for the immune system in the pathogenesis of hepatitis B virus induced liver disease. (1981) (2)
The Role of the Cytotoxic T Lymphocyte Response in Hepatitis B Virus Immunobiology and Pathogenesis (1994) (2)
Viral immunology: challenges associated with the progression from bench to clinic. (2002) (2)
The role of cytotoxic T lymphocytes and inflammatory cytokines in the pathogenesis of acute viral hepatitis (1993) (2)
Protective and Pathogenic T Cell Responses to Virus Infections (2016) (1)
Hepatitis C Virus-specific Cytotoxic T Lymphocytes Restricted by HLA-A2 are Present in the Peripheral Blood of Patients with Chronic Hepatitis C (1994) (1)
Persistent Hepatitis C Virus Infection In Vitro: Coevolution of Virus and Host (cid:1) † (2006) (1)
O.068 Robust hepatitis C virus infection in vitro: coevolution of virus and host (2006) (1)
Activation of Multidrug Resistance (P-Glycoprotein) mdr3/mdrla Gene during the Development of Hepatocellular Carcinoma in Hepatitis B (1992) (1)
Antigen Transgene-Encoded Hepatitis B Surface Are Excluded from the Liver that Expresses Responses to the Hepatitis B Surface Antigen Ongoing Murine T 1 or T 2 Immune (2000) (1)
Viral escape from the HLA-A2 restricted cytotoxic T lymphocyte response is not common during chronic hepatitis C virus infection (1995) (1)
Theimunopathogenesis of cronic HBV inducedliver disease (1981) (1)
Pathogenesis of Hepatitis B Virus inTransgenic Mice (2005) (1)
Frontiers in Drug Development for Viral Hepatitis The 6th biennial meeting in this HEP DART series (2005) (1)
The transgenic mouse model of hepatitis B virus infection (1996) (1)
Pioneers of pathogenesis: past and present. (2011) (0)
P508 - Role of peptide affinity for tap and maturation in the endoplasmic reticulum in epitope selection by antigen processing (1996) (0)
Synthetic hepatitis B virus vaccine containing T cell and B-zellenbestimmer. (1985) (0)
Expression ofHepatitis B VirusSurface andCoreAntigens: Influences ofPre-SandPrecore Sequencest (1987) (0)
Immunoregulatory Lipoproteins, Viral Hepatitis, and Cancer (1980) (0)
in Primary Hepatocytes Inhibits Duck Hepatitis B Virus Replication Recombinant Duck Interferon Gamma (2013) (0)
Hepatocarcinogenesis in Hepatitis B Virus Transgenic Mice Structurally and Functionally Intact during Multiple Oncogenes and Tumor Suppressor Genes Are Updated (2006) (0)
Extracellular HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV pathogenesis (2020) (0)
Virus-Transgenic Mice B Virus Surface Antigen in Hepatitis B Overcoming T Cell Tolerance to the Hepatitis (2000) (0)
Stefan Assembly and Egress Regulate HCV RNA Replication and Virus of Stress Granules Whose Proteins Hepatitis C Virus ( HCV ) Induces Formation (2012) (0)
This information is current as Response to a Single Viral Epitope Polyclonality and Multispecificity of the CTL (1998) (0)
Cytotoxic T Lymphocyte Response to a Wild Type Hepatitis B Virus Epitope in Patients Chronically Infected by Variant Viruses Carrying Substitutions (2003) (0)
Distinct H-2-1 inked Ir Genes Control Ant ibody Responses to Different HBsAg Determinants on the Same Molecule and Map to the I-A and IC Subregions (2003) (0)
Persistence of hepatitis C after homolgous monoclonal re-challenge associated with the emergence of new virus variants (2003) (0)
Synthetic vaccine against hepatitis B virus containing both T cell and B cell determinants (1985) (0)
T-Cell Response to Hepatitis B and C Virus: Lessons from the Chimpanzee Model (2005) (0)
Phenotypic patterns of preneoplastic and neoplastic hepatic lesions in hepatitis B virus transgenic mice (1991) (0)
the Liver of Transgenic Mice Cells Inhibit Hepatitis B Virus Replication in Activated Intrahepatic Antigen-Presenting (2002) (0)
This information is current as in the Liver Induces Hepatitis Break of T Cell Ignorance to a Viral Antigen (2000) (0)
Platelets Mediate Clearance of Lymphocytic Choriomeningitis Virus Infection Preventing Lethal Hemorrhage. (2006) (0)
LiverRequire Inflammatory Cell Recruitment to the Replication by Activated NK T Cells Does Not Cutting Edge: Inhibition of Hepatitis B Virus (2001) (0)
Include synthetic hepatitis B viral vaccin som innehaoller Baode cellens T-and B-cellens determinanter. (1985) (0)
Hepatitis C virus NS5A anchor peptide inhibits both HIV-1 and herpes simplex virus infection: The perfect microbicide? (2011) (0)
Heterotransplantability of an in-vitro transformed human lymphoblas- toid cell line. Abstr. (1971) (0)
Hepatitis Mice Cytotoxic T Lymphocyte Tolerance in Dendritic Cell Immunization Breaks (1998) (0)
LYMPHOCYTE RESPONSES TO HEPATITIS B VIRUS (2017) (0)
Role of Fas Ligand in Immunopathogenesis of Hepatocellular Carcinoma (2002) (0)
Effector CD 8 + T cell-derived interleukin-10 enhances acute liver immunopathology Graphical (2017) (0)
Analysis of Hepatitis B Virus Gene Expression in Transgenic Mice (1989) (0)
Expression of HBV envelope and nucleocapsid proteins in human cells using vaccinia virus vectors. (1990) (0)
Peptides and Definition of Their Peptide Molecules That Bind HLA Supertype Identification of Five Different Patr Class I (2000) (0)
Chimeric Antigen Antigen by Plasmid DNA Vaccines Encoding Determinants of the Hepatitis B Surface Selected T Cell- or Antibody-Defined Targeting Murine Immune Responses to (2000) (0)
of Birmingham Persistent hepatitis C virus infection in vitro: Coevolution of virus and host (2006) (0)
STUDIES ON THE HUMAN T LYMPHOCYTE – SHEEP ERYTHROCYTE RECEPTOR (1977) (0)
Therapeutic Vaccination in Humans Infection and its Role in Response to Associated with Chronic Hepatitis B Virus Altered Helper T Lymphocyte Function (1999) (0)
Foerfarande Foer framstaellning of a vaccin against hepatitis B virus. (1985) (0)
Virus Persistence after Recovery from Acute Viral Hepatitis (2013) (0)

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