Frank Beier
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German–Canadian orthopedist
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Why Is Frank Beier Influential?
(Suggest an Edit or Addition)According to Wikipedia, Frank Beier is a German–Canadian orthopedist. He is a Tier 1 Canada Research Chair in Musculoskeletal Research at the University of Western Ontario. Early life and education Beier was born and raised in Germany where he completed his Diploma of Biology and PhD at the University of Erlangen–Nuremberg. He then traveled to North America to complete his post-doctoral training at the University of Calgary.
Frank Beier's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer. (2015) (646)
- Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer: Retrospective Analyses of the CRYSTAL and FIRE-3 Trials (2017) (532)
- RhoA/ROCK Signaling Regulates Sox9 Expression and Actin Organization during Chondrogenesis* (2005) (289)
- Global analyses of gene expression in early experimental osteoarthritis. (2007) (253)
- Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions (2007) (241)
- FOLFOX4 plus cetuximab treatment and RAS mutations in colorectal cancer. (2015) (216)
- RhoA/ROCK Signaling Regulates Chondrogenesis in a Context-dependent Manner* (2006) (186)
- Updated survival analysis in patients with stage IIIB or IV non-small-cell lung cancer receiving BLP25 liposome vaccine (L-BLP25): phase IIB randomized, multicenter, open-label trial (2011) (181)
- Cartilage biology in osteoarthritis—lessons from developmental biology (2011) (169)
- Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes. (1999) (162)
- CCN2 Is Necessary for Adhesive Responses to Transforming Growth Factor-β1 in Embryonic Fibroblasts* (2006) (159)
- MAP kinases in chondrocyte differentiation. (2003) (153)
- Mouse models of osteoarthritis: modelling risk factors and assessing outcomes (2014) (150)
- Impact of tumor HPV status on outcome in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck receiving chemotherapy with or without cetuximab: retrospective analysis of the phase III EXTREME trial (2014) (147)
- Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis (2007) (140)
- p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation. (2004) (139)
- TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression. (2001) (131)
- Biology and pathology of Rho GTPase, PI‐3 kinase‐Akt, and MAP kinase signaling pathways in chondrocytes (2010) (129)
- RhoA/ROCK Signaling Suppresses Hypertrophic Chondrocyte Differentiation* (2004) (125)
- Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. (2005) (125)
- Rac1 Signaling Stimulates N-cadherin Expression, Mesenchymal Condensation, and Chondrogenesis* (2007) (117)
- Treatment outcome according to tumor RAS mutation status in OPUS study patients with metastatic colorectal cancer (mCRC) randomized to FOLFOX4 with/without cetuximab. (2014) (117)
- Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. (2013) (114)
- Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation (2010) (110)
- Early Changes of Articular Cartilage and Subchondral Bone in The DMM Mouse Model of Osteoarthritis (2018) (105)
- Rac1/Cdc42 and RhoA GTPases Antagonistically Regulate Chondrocyte Proliferation, Hypertrophy, and Apoptosis (2005) (101)
- p38 MAPK signaling during murine preimplantation development. (2004) (100)
- Genetic ablation of Rac1 in cartilage results in chondrodysplasia. (2007) (99)
- Chondrocyte hypertrophy in skeletal development, growth, and disease. (2014) (99)
- The Raf-1/MEK/ERK Pathway Regulates the Expression of the p21Cip1/Waf1 Gene in Chondrocytes* (1999) (93)
- The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification. (2009) (93)
- The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation (2008) (91)
- Cell‐cycle control and the cartilage growth plate (2005) (90)
- The Critical Role of the Epidermal Growth Factor Receptor in Endochondral Ossification (2011) (89)
- The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription (2006) (86)
- Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography. (2008) (79)
- C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and – independent pathways (2007) (79)
- Activating Transcription Factor 2 Is Necessary for Maximal Activity and Serum Induction of the Cyclin A Promoter in Chondrocytes* (2000) (75)
- Emerging Frontiers in cartilage and chondrocyte biology. (2011) (74)
- Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development (2007) (73)
- Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification. (2008) (69)
- Interplay between genetics and epigenetics in osteoarthritis (2020) (69)
- Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth. (2012) (68)
- ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis (2013) (68)
- Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. (2007) (67)
- Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype. (2013) (66)
- An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis (2012) (62)
- Recent developments in emerging therapeutic targets of osteoarthritis (2016) (60)
- Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase‐13 (2015) (59)
- Osteoarthritis year in review 2014: mechanics--basic and clinical studies in osteoarthritis. (2014) (59)
- The Pattern Recognition Receptor CD36 Is a Chondrocyte Hypertrophy Marker Associated with Suppression of Catabolic Responses and Promotion of Repair Responses to Inflammatory Stimuli 1 (2009) (59)
- Transcriptional regulators of chondrocyte hypertrophy. (2008) (58)
- Characterization of Human Type X Procollagen and Its NC-1 Domain Expressed as Recombinant Proteins in HEK293 Cells* (1998) (58)
- Reduction in Disease Progression by Inhibition of Transforming Growth Factor α–CCL2 Signaling in Experimental Posttraumatic Osteoarthritis (2015) (58)
- A multicenter open-label study to assess the safety of a new formulation of BLP25 liposome vaccine in patients with unresectable stage III non-small-cell lung cancer. (2010) (56)
- Targeting oxidative stress to reduce osteoarthritis (2016) (56)
- F‐spondin, a neuroregulatory protein, is up‐regulated in osteoarthritis and regulates cartilage metabolism via TGF‐β activation (2009) (56)
- Platinum-based Chemotherapy Plus Cetuximab for the First-line Treatment of Japanese Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck: Results of a Phase II Trial (2013) (56)
- Genomic organization and full‐length cDNA sequence of human collagen X (1992) (55)
- TGF-β and osteoarthritis—the good and the bad (2013) (55)
- Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. (2012) (54)
- Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. (2012) (53)
- Repeated Exposure to High‐Frequency Low‐Amplitude Vibration Induces Degeneration of Murine Intervertebral Discs and Knee Joints (2015) (53)
- Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model (2014) (51)
- p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation (2004) (50)
- Disturbed Cartilage and Joint Homeostasis Resulting From a Loss of Mitogen‐Inducible Gene 6 in a Mouse Model of Joint Dysfunction (2014) (50)
- Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation (2014) (49)
- Genome-Wide Analyses of Gene Expression during Mouse Endochondral Ossification (2010) (49)
- Role of c‐fos in the regulation of type X collagen gene expression by PTH and PTHrP: Localization of a PTH/PTHrP‐responsive region in the human COL10A1 enhancer (2002) (48)
- Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes. (2009) (48)
- Cell cycle genes in chondrocyte proliferation and differentiation. (1999) (48)
- Effect of KRAS and NRAS mutations on treatment outcomes in patients with metastatic colorectal cancer (mCRC) treated first-line with cetuximab plus FOLFOX4: New results from the OPUS study. (2014) (47)
- Focal Adhesion Kinase/Src Suppresses Early Chondrogenesis (2008) (46)
- The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease (2009) (46)
- Osteopontin mediates mineralization and not osteogenic cell development in vitro. (2014) (46)
- Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. (2015) (45)
- Faculty Opinions recommendation of Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. (2010) (44)
- Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis (2015) (44)
- Impact of tumor HPV status on outcome in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck receiving chemotherapy with or without cetuximab: retrospective analysis of the phase III EXTREME trial. (2014) (43)
- Role of interleukin-10 in endochondral bone formation in mice: anabolic effect via the bone morphogenetic protein/Smad pathway. (2013) (43)
- Targeting cartilage EGFR pathway for osteoarthritis treatment (2021) (43)
- Peroxisome Proliferator–Activated Receptor δ Promotes the Progression of Posttraumatic Osteoarthritis in a Mouse Model (2015) (42)
- Molecular and Histological Analysis of a New Rat Model of Experimental Knee Osteoarthritis (2007) (42)
- Endothelial nitric oxide synthase deficiency in mice results in reduced chondrocyte proliferation and endochondral bone growth. (2010) (41)
- The cyclin D1 and cyclin A genes are targets of activated PTH/PTHrP receptors in Jansen's metaphyseal chondrodysplasia. (2002) (40)
- Activating transcription factor 2 controls Bcl‐2 promoter activity in growth plate chondrocytes (2007) (40)
- C-type natriuretic peptide regulates cellular condensation and glycosaminoglycan synthesis during chondrogenesis. (2007) (39)
- Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression. (2011) (38)
- Src kinase inhibition promotes the chondrocyte phenotype (2007) (38)
- Upregulation of type X collagen expression in osteoarthritic cartilage. (1995) (38)
- Control of chondrocyte gene expression by actin dynamics: a novel role of cholesterol/Ror-α signalling in endochondral bone growth (2009) (37)
- Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth (2010) (37)
- Regulator of G‐protein signaling (RGS) proteins differentially control chondrocyte differentiation (2006) (37)
- Inhibition of p38 MAPK signaling in chondrocyte cultures results in enhanced osteogenic differentiation of perichondral cells. (2007) (36)
- Cell cycle control in growth plate chondrocytes. (2000) (36)
- Localization of silencer and enhancer elements in the human type X collagen gene (1997) (35)
- Loss of ATRX in Chondrocytes Has Minimal Effects on Skeletal Development (2009) (34)
- Effect of KRAS and NRAS mutational status on first-line treatment with FOLFIRI plus cetuximab in patients with metastatic colorectal cancer (mCRC): New results from the CRYSTAL trial. (2014) (34)
- Type X collagen expression and hypertrophic differentiation in chondrogenic neoplasias (1997) (33)
- Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes (2017) (32)
- Global deletion of Panx3 produces multiple phenotypic effects in mouse humeri and femora (2016) (32)
- Regulation of Gene Expression by PI3K in Mouse Growth Plate Chondrocytes (2010) (32)
- EGFR Signaling: Friend or Foe for Cartilage? (2019) (31)
- Loss of the Mammalian DREAM Complex Deregulates Chondrocyte Proliferation (2014) (31)
- Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice (2015) (31)
- Weight-bearing asymmetry and vertical activity differences in a rat model of post-traumatic knee osteoarthritis. (2015) (29)
- GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span. (2013) (29)
- Cartilage biology in osteoarthritis—lessons from developmental biology (2013) (29)
- Inducible nitric oxide synthase–nitric oxide signaling mediates the mitogenic activity of Rac1 during endochondral bone growth (2011) (29)
- Context-specific protection of TGFα null mice from osteoarthritis (2016) (28)
- Osteoarthritis, cerebrovascular dysfunction and the common denominator of inflammation: a narrative review. (2018) (26)
- The CPPDD-Associated ANKH M48T Mutation Interrupts the Interaction of ANKH with the Sodium/Phosphate Cotransporter PiT-1 (2009) (25)
- Choline kinase beta is required for normal endochondral bone formation. (2014) (25)
- FOLFIRI plus cetuximab in patients with liver-limited or non-liver-limited RAS wild-type metastatic colorectal cancer: A retrospective subgroup analysis of the CRYSTAL study. (2016) (23)
- Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly. (2013) (23)
- ECM signaling in cartilage development and endochondral ossification. (2019) (22)
- Determination of 5' ends of specific mRNAs by DNA ligase-dependent amplification. (1993) (22)
- F-Spondin Deficient Mice Have a High Bone Mass Phenotype (2014) (22)
- A phase I, dose-escalation study of the Eg5-inhibitor EMD 534085 in patients with advanced solid tumors or lymphoma (2013) (20)
- The ANKH ΔE490Mutation in Calcium Pyrophosphate Dihydrate Crystal Deposition Disease (CPPDD) Affects Tissue Non-specific Alkaline Phosphatase (TNAP) Activities (2008) (20)
- Rac1 activation induces tumour necrosis factor-α expression and cardiac dysfunction in endotoxemia (2010) (19)
- Variability in the upstream promoter and intron sequences of the human, mouse and chick type X collagen genes. (1996) (19)
- Reduced chondrocyte proliferation, earlier cell cycle exit and increased apoptosis in neuronal nitric oxide synthase-deficient mice. (2012) (18)
- A new prescription for growth? Statins, cholesterol and cartilage homeostasis. (2015) (18)
- Raf signaling stimulates and represses the human collagen X promoter through distinguishable elements (1999) (18)
- p16, HPV, and Cetuximab: What Is the Evidence? (2017) (18)
- Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone. (2017) (17)
- Rho-ROCK signaling differentially regulates chondrocyte spreading on fibronectin and bone sialoprotein. (2008) (17)
- Efficacy, Tolerability, and Biomarker Analyses of Once‐Every‐2‐Weeks Cetuximab Plus First‐Line FOLFOX or FOLFIRI in Patients With KRAS or All RAS Wild‐Type Metastatic Colorectal Cancer: The Phase 2 APEC Study (2017) (17)
- Dexamethasone stimulates expression of C-type Natriuretic Peptide in chondrocytes (2006) (16)
- CXC chemokine ligand 12a enhances chondrocyte proliferation and maturation during endochondral bone formation. (2015) (16)
- Poly(ester amide) particles for controlled delivery of celecoxib. (2019) (16)
- Transforming growth factor‐alpha induces endothelin receptor A expression in osteoarthritis (2012) (15)
- Are we missing the target? Are we aiming too low? What are the aerobic exercise prescriptions and their effects on markers of cardiovascular health and systemic inflammation in patients with knee osteoarthritis? A systematic review and meta-analysis (2019) (15)
- Quality of Life Analysis in Patients With RAS Wild‐Type Metastatic Colorectal Cancer Treated With First‐Line Cetuximab Plus Chemotherapy (2017) (14)
- The role of bone sialoprotein in the tendon-bone insertion. (2016) (13)
- C57BL/6 mice are resistant to joint degeneration induced by whole-body vibration. (2017) (13)
- Serum induction of the collagen X promoter requires the Raf/MEK/ERK and p38 pathways. (1999) (13)
- Mosaic expression of Atrx in the mouse central nervous system causes memory deficits (2017) (12)
- PPARγ2 expression in growth plate chondrocytes is regulated by p38 and GSK-3 (2008) (11)
- Transcriptional Regulation of the Human Type X Collagen Gene Expression (1996) (11)
- Thermoresponsive and Covalently Cross-Linkable Hydrogels for Intra-Articular Drug Delivery (2019) (10)
- Activation and fluoride-assisted phosphating of aluminum-silicon-coated steel. (2013) (10)
- Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging‐Induced Osteoarthritis in Mice (2021) (10)
- The Role of Activating Transcription Factor-2 in Skeletal Growth Control (2003) (9)
- Developmental biology: Is there such a thing as a cartilage-specific knockout mouse? (2014) (9)
- Dicam promotes proliferation and maturation of chondrocyte through Indian hedgehog signaling in primary cilia. (2018) (8)
- MAPK signaling during murine preimplantation development (2004) (8)
- Nuclear receptors as potential drug targets in osteoarthritis (2018) (8)
- Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis (2015) (8)
- The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration (2021) (8)
- Liver X Receptor activation delays chondrocyte hypertrophy during endochondral bone growth. (2014) (7)
- Exposure to the RXR Agonist SR11237 in Early Life Causes Disturbed Skeletal Morphogenesis in a Rat Model (2019) (7)
- OP041: Impact of human papillomavirus (HPV) and p16 status on survival and response with cisplatin plus 5-FU and cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): Analysis of the phase III extreme trial (2013) (7)
- Efficacy and safety of first-line cetuximab + FOLFIRI in older and younger patients (pts) with RAS wild-type (wt) metastatic colorectal cancer (mCRC) in the CRYSTAL study. (2016) (7)
- The first international workshop on the epigenetics of osteoarthritis (2017) (6)
- 063 THE ROLE OF AKT1 IN TERMINAL STAGES OF ENDOCHONDRAL BONE FORMATION: ANGIOGENESIS AND OSSIFICATION (2009) (6)
- EGFR Signaling Is Required for Maintaining Adult Cartilage Homeostasis and Attenuating Osteoarthritis Progression (2022) (6)
- Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice (2019) (6)
- NFATs are good for your cartilage! (2014) (6)
- An approach towards accountability: suggestions for increased reproducibility in surgical destabilization of medial meniscus (DMM) models. (2017) (6)
- Transforming Growth Factor Suppression of Articular Chondrocyte Phenotype and Sox9 Expression in a Rat Model of Osteoarthritis (2007) (6)
- Quantification of joint blood flow by dynamic contrast-enhanced near-infrared spectroscopy: application to monitoring disease activity in a rat model of rheumatoid arthritis (2020) (5)
- O-0020OUTCOME ACCORDING TO TUMOR RAS MUTATION STATUS IN CRYSTAL STUDY PATIENTS WITH METASTATIC COLORECTAL CANCER RANDOMIZED TO FOLFIRI WITH OR WITHOUT CETUXIMAB AS FIRST-LINE TREATMENT (2014) (5)
- Identification of the putative collagen X gene from the pufferfish Fugu rubripes. (2004) (5)
- Loss of ATRX Does Not Confer Susceptibility to Osteoarthritis (2013) (5)
- Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice (2020) (5)
- Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis (2015) (5)
- Rac1 Dosage Is Crucial for Normal Endochondral Bone Growth (2017) (5)
- GSK3787-Loaded Poly(Ester Amide) Particles for Intra-Articular Drug Delivery (2020) (5)
- Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice (2021) (4)
- Phase 1, open-label, dose-escalation study of M3814 + avelumab ± radiotherapy (RT) in patients (pts) with advanced solid tumors. (2019) (4)
- Osteoarthritis year in review 2014: mechanics (2014) (3)
- Randomized, phase Ib/II study of M6620 + avelumab + carboplatin vs standard care (sc) in patients (pts) with platinum-sensitive poly (ADP-ribose) polymerase inhibitor-(PARPi)-resistant ovarian cancer (2019) (3)
- 2120 Quality of life analysis in patients with RAS wild-type metastatic colorectal cancer treated with first-line FOLFIRI + cetuximab in the CRYSTAL study (2015) (3)
- Correction: Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis (2008) (3)
- Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling (2021) (2)
- Investigation of articular cartilage structural and biomechanical properties by atomic-force microscopy (2018) (2)
- Faculty Opinions recommendation of Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow. (2012) (2)
- Pannexin 3 deletion reduces fat accumulation and inflammation in a sex-specific manner (2021) (2)
- A mechanistic study of wetting and dewetting during hot dip galvanising of high strength steels (2006) (2)
- Tepotinib plus cetuximab in patients (pts) with RAS/BRAF wild-type left-sided metastatic colorectal cancer (mCRC) and acquired resistance to anti-EGFR antibody therapy due to MET amplification (METamp). (2021) (2)
- Loss of mitogen-inducible gene 6 results in disturbed cartilage and joint homeostasis (2014) (2)
- Polymer particles for the intra-articular delivery of drugs to treat osteoarthritis (2021) (2)
- Investigating the role of Retinoid X Receptor in cartilage development and homeostasis (2018) (2)
- Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in mice (2020) (2)
- 541PFOLFIRI PLUS CETUXIMAB IN PATIENTS WITH LIVER-LIMITED OR NON-LIVER-LIMITED RAS WILD-TYPE METASTATIC DISEASE: A SUB-GROUP ANALYSIS OF THE CRYSTAL STUDY. (2014) (2)
- Skeletal development and regeneration (1999) (2)
- Cholesterol and cartilage do not mix well (2019) (2)
- Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine (2018) (1)
- A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis (2015) (1)
- Activating EGFR Signaling Attenuates Osteoarthritis Development Following Loading Injury in Mice (2022) (1)
- MS201944-0170: A phase IIa study to investigate the clinical activity and safety of avelumab in combination with cetuximab plus gemcitabine and cisplatin in patients with advanced squamous NSCLC. (2019) (1)
- Early Changes of Articular Cartilage and Subchondral Bone in The DMM Mouse Model of Osteoarthritis (2018) (1)
- Reliability and sensitivity to change of bone marrow lesion scores using the knee inflammation MRI scoring system (KIMRISS) before and after high tibial osteotomy (2020) (1)
- Pannexin 3, but not pannexin 1 is an important pro-catabolic mediator in osteoarthritis. (2016) (1)
- Gene array profiling of articular chondrocytes in mice with different susceptibility to natural disease reveals specific gene signatures linked to healthy ageing and spontaneous OA (2012) (1)
- Elevated expression of periostin in human osteoarthritis cartilage and its potential role in matrix degradation via MMP-13 (2015) (1)
- Preparation of a novel intra-articular polymeric drug delivery system (2018) (1)
- EGFR/ MIG-6 signalling in osteoarthritis (2017) (1)
- Liver X Receptor activation regulates genes involved in lipid homeostasis in developing chondrocytes (2019) (1)
- PGC1A is required for chondrocyte metabolism and cartilage homeostasis (2020) (1)
- Keep your Sox on, chondrocytes! (2021) (1)
- PPARdelta promotes the progression of post-traumatic osteoarthritis (2014) (1)
- Quantifying joint blood flow in a rat model of rheumatoid arthritis with dynamic contrast-enhanced near-infrared spectroscopy (2019) (1)
- Overexpression of Mig-6 in cartilage induces an osteoarthirtis-like phenotype in mice (2019) (1)
- Rac1/iNos/nitric oxide signaling is required for chondrocyte proliferation and endochondral bone growth (2008) (1)
- Component of press-hardened aluminum-coated steel sheet and method for producing such a component and its use (2016) (0)
- Rac 1 dosage in bone growth Rac 1 dosage is crucial for normal endochondral bone growth (2017) (0)
- SWITCHING PHYSIOLOGY: CHANGES IN BIOLOGICAL MARKERS OF KNEE INFLAMMATION AFTER HIGH TIBIAL OSTEOTOMY (2022) (0)
- The Rxr agonist SR 11237 causes disturbed skeletal morphogenesis in a rat model (2014) (0)
- CCN2 is essential for early chondrogenesis (2008) (0)
- [Treatment of penicillin-sensitive staphylococcus aureus]. (2016) (0)
- Strain and model specific differences in mouse models of osteoarthritis (2018) (0)
- Pannexin 3: A new channel into the mechanisms of osteoarthritis (2014) (0)
- Faculty Opinions recommendation of Targeted deletion of Sost distal enhancer increases bone formation and bone mass. (2012) (0)
- 265 Phase 1b study of avelumab + M9241 (NHS-IL12) in patients with advanced solid tumors: interim analysis results from a urothelial carcinoma (UC) dose-expansion cohort (2020) (0)
- 228 P38 AND MEK/ERK MAP KINASES REGULATE COMMON AND UNIQUE GENE SETS IN CHONDROCYTES (2010) (0)
- Acknowledgment of Reviewers for 2011 (2012) (0)
- F-spondin (spondin-1) null mice exhibit increased bone formation, decreased osteoclast function and accelerated osteoarthritis (2012) (0)
- Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes (2017) (0)
- 74 ADAMTS-7 CONSTITUTES A POSITIVE FEEDBACK LOOP WITH TNF” IN REGULATING CARTILAGE DEGRADATION AND OSTEOARTHRITIS (2011) (0)
- The effects of delayed administration of rho-kinase inhibitor fasudil on surgically induced osteoarthritis in rats (2012) (0)
- Endothelial Pannexin 3 – B Cell Lymphoma‐6 Interactions Protect Against Oxidative Stress (2022) (0)
- A systematic review of aerobic exercise programs for patients with knee osteoarthritis and meta-analyses of physiological effects (2019) (0)
- Signaling pathways in chondrocyte pathology (2012) (0)
- Lineage Tracing of MIG-6 Deficient Cells in the Development of Ectopic Chondro-Osseous Nodules in a Genetic Mouse Model of Joint Disruption (2017) (0)
- 193 MOLECULAR CONTROL OF ARCTICULAR CARTILAGE DEGENERATION BY TRANSFORMING GROWTH FACTOR ALPHA (2008) (0)
- 155 PI3K REGULATES CHONDROCYTE DIFFERENTIATION (2007) (0)
- Ternary molybdenum(III) chlorides (1997) (0)
- Evaluating pharmacological inhibition of PPARdelta in a rat model of post-traumatic osteoarthritis (2019) (0)
- Cartilage-specific deletion of prar-gamma in mice results in early endochondral ossification defects and accelerated aging-dependent development of osteoarthritis (2012) (0)
- Anabolic phenotype in cartilage-specific Mitogen-inducible gene-6 knockout mice is independent of Transforming growth factor-α (2023) (0)
- 190 CARTILAGE-SPECIFIC DELETION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA IN MICE IS ASSOCIATED WITH GROWTH PLATE DEFECTS (2010) (0)
- Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running (2023) (0)
- Opposite roles of pannexins in post-traumatic versus aging associated osteoarthritis (2018) (0)
- Abstract A162: Identification of brain penetrant p70S6K/Akt inhibitor MSC2363318A. (2013) (0)
- Sequence analysis of regulatory regions of the human collagen X gene (1996) (0)
- Monitoring joint blood flow with DCE TR-NIRS to assess treatment response in rheumatoid arthritis (2018) (0)
- Title : Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints Running Title : Whole body vibration induces joint degeneration (2015) (0)
- Investigating the role of nuclear receptors liver x receptor and retinoid x receptor in cartilage development and homeostasis (2017) (0)
- 086 THE ROLE OF TRANSFORMING GROWTH FACTOR ALPHA IN A MOUSE MODEL OF OSTEOARTHRITIS (2009) (0)
- Early subchondral bone changes in an osteoarthritis model in wild type and tgf-alpha knockout mice (2014) (0)
- Component made pressformgehärtetem, based on aluminum coated steel sheet and method for producing such a component and its use (2016) (0)
- Best Oral Presentations (OP01–OP12) (2012) (0)
- Reply to S. Debska-Szmich et al. (2015) (0)
- Editorial: Changes in Messenger RNA Stability in Chondrocytes: There's More to Osteoarthritis Than Transcription (2014) (0)
- A10 F-SPONDIN, A NEURONAL DIFFERENTIATION FACTOR, IS UPREGULATED IN OSTEOARTHRITIS: EVIDENCE FOR REGULATION OF CHONDROCYTE METABOLISM VIA LATENT TGF-B1 ACTIVATION (2006) (0)
- ligase-dependent amplification. Determination of 5' ends of specific mRNAs by DNA (2011) (0)
- Influence of additive elements on galvanising of high strength steels (2004) (0)
- ANKH with the Sodium / Phosphate Cotransporter PiT-1 Mutation Interrupts the Interaction of ANKH M 48 T The CPPDD-Associated (2009) (0)
- Role of stromal cell-derived factor-1 alpha on endochondral ossification (2012) (0)
- Phosphate crystallization on zinc and steel surfaces (2010) (0)
- Strain-dependent differences in age-associated osteoarthritis pathogenesis (2017) (0)
- Characterizing the role of ppardelta in the progression of behavioural and histologic secondary osteoarthritis (2016) (0)
- TGFα effects on cartilage is mechanical stress-dependent (2019) (0)
- The role of nuclear receptors liver X receptor and retinoid X receptor in murine cartilage (2016) (0)
- 39 EXPRESSION OF THE PATTERNING RECEPTOR CD36 IS CHONDROPROTECTIVE BY DISENGAGING INFLAMMATION FROM DYSREGULATED CHONDROCYTE DIFFERENTIATION AND FUNCTION (2007) (0)
- P-111 PERSPECTIVE: Tepotinib plus cetuximab in patients with RAS/BRAF wild-type left-sided metastatic colorectal cancer and acquired resistance to anti-EGFR antibody therapy due to MET amplification (2021) (0)
- 128 INHIBITION OF TRANSFORMING GROWTH FACTOR ALPHA SIGNALING SLOWS PROGRESSION OF OSTEOARTHRITIS (2011) (0)
- Behavioral variables are associated with surgically induced knee osteoarthritis in rats (2014) (0)
- PPARdelta as a novel target for osteoarthritis therapy (2013) (0)
- List of Reviewers January–November 2015 (2015) (0)
- Clinical Connections (2021) (0)
- Immunostaining for markers of chondrocyte hypertrophy (2011) (0)
- O-015Association between depth of response (DpR) and survival outcomes in RAS-wild-type (wt) patients with metastatic colorectal cancer (mCRC) receiving first-line FOLFOX or FOLFIRI plus cetuximab once-every-2-weeks in the APEC study (2016) (0)
- 240 GENES COMMONLY REGULATED BY THE P38 MAPK AND PI3K SIGNALING PATHWAYS IN HYPERTROPHIC GROWTH PLATE CHONDROCYTES (2008) (0)
- Emerging therapeutic targets for osteoarthritis (2023) (0)
- Preparation of a polymeric intra-articular PPAR deltaantagonist delivery system (2019) (0)
- 2112 Association between early tumour shrinkage and outcomes in RAS-wild type patients with metastatic colorectal cancer receiving first-line FOLFOX or FOLFIRI + cetuximab once every 2 weeks in the APEC study (2015) (0)
- Reduced weight, adhesion optimized steel / plastic / composite steel sheet having excellent suitability for resistance welding (2016) (0)
- The role of liver X receptor in chondrocyte differentiation and osteoarthritis (2015) (0)
- Role of interleukin-10 in endochondral bone formation (2013) (0)
- Corrigendum to “Weight-bearing asymmetry and vertical activity differences in a rat model of post-traumatic knee osteoarthritis” [Osteoarthritis Cartilage 23 (7) (2015) 1178–85] (2016) (0)
- 215 TRANSFORMING GROWTH FACTOR ALPHA AND ENDOTHELIN RECEPTOR A SIGNALING IN OSTEOARTHRITIS (2008) (0)
- 149PDAssociation between early tumour shrinkage (ETS) and outcomes in RAS-wild type (WT) patients (pts) with metastatic colorectal cancer (mCRC) receiving first-line FOLFOX or FOLFIRI + cetuximab every other week in the APEC study (2015) (0)
- Genetic deletion of interleukin-15 is not associated with major structural changes following experimental post-traumatic knee osteoarthritis in rats (2021) (0)
- Correction to “Thermoresponsive and Covalently Cross-Linkable Hydrogels for Intra-Articular Drug Delivery” (2021) (0)
- I-22 RHO SIGNALING PATHWAYS IN CARTILAGE DEVELOPMENT AND OSTEOARTHRITIS (2008) (0)
- Loss of adseverin, an actin binding protein, in an animal model of osteoarthritis (2021) (0)
- Cartilage specific deletion of mitogen inducible gene 6 in mice increases articular cartilage thickness in late adulthood (2015) (0)
- Reduced Epidermal Growth Factor Receptor ( EGFR ) Signaling Enhances Cartilage Destruction in Mouse Osteoarthritis Model (2015) (0)
- 093 INHIBITION OF TRANSFORMING GROWTH FACTOR ALPHA SIGNALING SLOWS PROGRESSION OF OSTEOARTHRITIS (2010) (0)
- MOLECULAR CONTROL OF ARTICULAR CARTILAGE DEGENERATION BY TRANSFORMING GROWTH FACTOR ALPHA (2008) (0)
- Cartilage Differentiation and the Actin Cytoskeleton (2016) (0)
- OP0065 INTER-RATER RELIABILITY AND VALIDITY OF MEDIAL AND LATERAL FEMORAL BONE MARROW LESIONS IN PATIENTS WITH OSTEOARTHRITIS UNDERGOING TIBIAL OSTEOTOMY USING THE KNEE INFLAMMATION MRI SCORING SYSTEM (KIMRISS) (2020) (0)
- Endogenous mechanisms and pathways of cartilage healing (2015) (0)
- Faculty Opinions recommendation of Mechanical activation of mammalian target of rapamycin pathway is required for cartilage development. (2014) (0)
- PD-0001CETUXIMAB EVERY 2 WEEKS WITH FIRST-LINE CHEMOTHERAPY IN APEC STUDY PATIENTS WITH METASTATIC COLORECTAL CANCER GROUPED ACCORDING TO EGFR EXPRESSION (2014) (0)
- Associations between surgically-induced changes in knee loading and biochemical markers of knee inflammation (2021) (0)
- Faculty Opinions recommendation of Fibroblast growth factor receptor 3 inhibits osteoarthritis progression in the knee joints of adult mice. (2016) (0)
- Faculty Opinions recommendation of TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. (2013) (0)
- 383 GENE EXPRESSION PROFILE IN THE ARTICULAR CARTILAGE OF A NATURAL MODEL OF MOUSE OSTEOARTHRITIS (2010) (0)
- The role of glycogen synthase kinase-3 in limb development and patterning (2013) (0)
- Targeting cartilage epidermal growth factor receptor signaling pathway for osteoarthritis treatment (2021) (0)
- Genes and Joints (2010) (0)
- The impact of omics research on our understanding of osteoarthritis and future treatments. (2022) (0)
- The rock inhibitor fasudil does not protect against cartilage degeneration in a rat model of post-traumatic OA (2016) (0)
- 189 IMPAIRED EXPRESSION OF GENES INVOLVED IN REVERSE CHOLESTEROL TRANSPORT IN HUMAN OSTEOARTHRITIC CHONDROCYTES: BENEFICIAL EFFECT OF LXR AGONIST TREATMENT (2010) (0)
- Converting a leukemic transcription factor into a powerful tool for large-scale ex vivo production of human phagocytes (2021) (0)
- Inorganic carbonate - based conversion coating on galvanised steel (2013) (0)
- Inhibition of transforming growth factor alpha signaling slows progression of osteoarthritis in a dmm model (2012) (0)
- GSK-3 knock out protects articular cartilage under osteoarthritic conditions but induces growth plate closure (2020) (0)
- Development of osteoarthritis and disruption of knee joint morphology in a cartilage specific mitogen inducible gene 6 deletion mouse (2013) (0)
- 214 CONTROL OF CHONDROCYTE GENE EXPRESSION BY ACTIN DYNAMICS: A NOVEL ROLE OF CHOLESTEROL/RORα SIGNALING (2008) (0)
- Overexpression of Mig-6 in Limb Mesenchyme Leads to Accelerated Osteoarthritis in Mice (2019) (0)
- 132 MORE EVIDENCE THAT LOCAL TREATMENT MATTERS: AN UPDATED SURVIVAL ANALYSIS OF RADICAL PROSTATECTOMY AND PELVIC LYMPHADENECTOMY (PLND) (PT2-4) VERSUS PLND ALONE (PTX) IN MEN WITH LYMPH NODE POSITIVE DISEASE (2010) (0)
- Polarized Intracellular Endothelial Pannexin 3 Can Regulate Vascular Function (2020) (0)
- Effect of double knockout of cartilage-specific mitogen-inducible gene 6 and transforming growth factor-alpha on joint homeostasis (2018) (0)
- Acknowledgment of Reviewers, 2019 (2019) (0)
- 190 THE REGULATION OF CHONDROCYTE DIFFERENTIATION BY RHO GTPASES AND THE ACTIN CYTOSKELETON (2007) (0)
- Global gene expression analyses in early experimental osteoarthritis reveal novel players in articular cartilage degenerations (2007) (0)
- 59 CARTILAGE-SPECIFIC DELETION OF PPAR-GAMMA IN MICE RESULTS IN EARLY ENDOCHONDRAL OSSIFICATION DEFECTS AND ACCELERATED AGING-DEPENDENT DEVELOPMENT OF OSTEOARTHRITIS (2011) (0)
- Faculty Opinions recommendation of Novel genetic variants for cartilage thickness and hip osteoarthritis. (2017) (0)
- Targeting glycogen synthase kinase 3 signaling in cartilage biology: RNA-SEQ based transcriptome profiling (2018) (0)
- Investigating the role of nuclear receptor proliferator-activated receptor delta (PPARδ) in aging and metabolic models of osteoarthritis (2019) (0)
- Faculty Opinions recommendation of LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model. (2011) (0)
- A Na+/K+ ATPase Pump Regulates Chondrocyte Differentiation and Bone Length Variation in Mice (2021) (0)
- Investigating the role of panx3 in mechanostimulation and pro-inflammatory responses in chondrocytes (2017) (0)
- Trabecular bone phenotype in cartilage-specific inactivation of the Rac1 gene in mice (2010) (0)
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