Franklin David Costantini | Academic Influence

Why Is Franklin David Costantini Influential?

Franklin David Costantini's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Manipulating the mouse embryo: A laboratory manual (1986) (4048)
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus (2001) (2923)
Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway (2002) (1643)
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret (1994) (1604)
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1 (1991) (1313)
The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation (1997) (944)
Expression of the c-ret proto-oncogene during mouse embryogenesis. (1993) (842)
GDNF signalling through the Ret receptor tyrosine kinase (1996) (821)
Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion. (1994) (745)
Manipulating the Mouse Embryo (2007) (717)
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. (2010) (617)
Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. (1996) (446)
Introduction of a rabbit β-globin gene into the mouse germ line (1981) (420)
Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. (1996) (412)
Development of hematopoietic cells lacking transcription factor GATA-1. (1995) (384)
Transgenic mice expressing a human poliovirus receptor: A new model for poliomyelitis (1990) (384)
Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction (2005) (359)
Erythropoietin receptor signalling is required for normal brain development. (2002) (351)
Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. (2005) (349)
Developmental Regulation of Wnt/β-Catenin Signals Is Required for Growth Plate Assembly, Cartilage Integrity, and Endochondral Ossification* (2005) (333)
The role of Axin2 in calvarial morphogenesis and craniosynostosis (2005) (325)
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice (1990) (325)
Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development. (1996) (323)
GDNF/Ret signaling and the development of the kidney. (2006) (309)
Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization (1999) (287)
Identification of a Domain of Axin That Binds to the Serine/Threonine Protein Phosphatase 2A and a Self-binding Domain* (1999) (280)
Vitamin A controls epithelial/mesenchymal interactions through Ret expression (2001) (262)
Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody (1984) (261)
Rescue of erythroid development in gene targeted GATA–1− mouse embryonic stem cells (1992) (258)
Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. (2001) (257)
Expression of green fluorescent protein in the ureteric bud of transgenic mice: a new tool for the analysis of ureteric bud morphogenesis. (1999) (244)
The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis. (2005) (242)
A foreign β-globin gene in transgenic mice: Integration at abnormal chromosomal positions and expression in inappropriate tissues (1983) (231)
C-myc as an inducer of polycystic kidney disease in transgenic mice. (1991) (220)
Increased susceptibility in Hp knockout mice during acute hemolysis. (1998) (218)
Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. (2009) (211)
Real-time analysis of ureteric bud branching morphogenesis in vitro. (2004) (207)
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. (1990) (201)
Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis (2009) (198)
Specific expression of a foreign β-globin gene in erythroid cells of transgenic mice (1985) (196)
Renal branching morphogenesis: concepts, questions, and recent advances. (2006) (180)
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin (2008) (172)
Developmental regulation of a cloned adult β-globin gene in transgenic mice (1985) (170)
An embryonic pattern of expression of a human fetal globin gene in transgenic mice (1986) (165)
Two dominant mutations in the mouse fused gene are the result of transposon insertions. (1997) (161)
A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes (1985) (156)
C‐cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B (2000) (152)
Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret (2002) (149)
Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1. (2006) (149)
Non-cell-autonomous retinoid signaling is crucial for renal development (2010) (146)
Kidney Development in the Absence of Gdnf and Spry1 Requires Fgf10 (2010) (144)
Gata3 Acts Downstream of β-Catenin Signaling to Prevent Ectopic Metanephric Kidney Induction (2008) (143)
Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice (2001) (139)
Expression of the cret proto-oncogene during mouse embryogenesis (1996) (135)
Novel regulators of kidney development from the tips of the ureteric bud. (2005) (132)
Mouse Axin and Axin2/Conductin Proteins Are Functionally Equivalent In Vivo (2005) (130)
In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. (1995) (129)
SOX9 controls epithelial branching by activating RET effector genes during kidney development. (2011) (122)
Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development. (1999) (119)
A 3' enhancer contributes to the stage-specific expression of the human beta-globin gene. (1987) (112)
SUMO-Specific Protease 2 Is Essential for Modulating p53-Mdm2 in Development of Trophoblast Stem Cell Niches and Lineages (2008) (107)
The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. (2014) (105)
GDNF/Ret signaling and renal branching morphogenesis (2007) (103)
Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells (2006) (103)
RET proto-oncogene is important for the development of respiratory CO2 sensitivity. (1997) (102)
Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus. (1995) (102)
Genetic controls and cellular behaviors in branching morphogenesis of the renal collecting system (2012) (101)
Message sequences and short repetitive sequences are interspersed in sea urchin egg poly(A)+ RNAs (1980) (101)
Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud. (2013) (99)
Introduction of a rabbit beta-globin gene into the mouse germ line. (1981) (97)
Purification of GSK-3 by affinity chromatography on immobilized axin. (2000) (97)
A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity. (1995) (92)
Phosphotyrosine 1062 Is Critical for the In Vivo Activity of the Ret9 Receptor Tyrosine Kinase Isoform (2005) (91)
Specific representation of cloned repetitive DNA sequences in sea urchin RNAs (1978) (90)
The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse. (2001) (85)
The dependence receptor Ret induces apoptosis in somatotrophs through a Pit‐1/p53 pathway, preventing tumor growth (2007) (85)
Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion. (1992) (82)
The role of GDNF in patterning the excretory system. (2005) (81)
A GSK3β Phosphorylation Site in Axin Modulates Interaction with β-Catenin and Tcf-Mediated Gene Expression (1999) (81)
Correction of murine beta-thalassemia by gene transfer into the germ line. (1986) (81)
Constitutive Ret Activity in Knock-In Multiple Endocrine Neoplasia Type B Mice Induces Profound Elevation of Brain Dopamine Concentration via Enhanced Synthesis and Increases the Number of TH-Positive Cells in the Substantia Nigra (2007) (78)
Developmental regulation of human globin genes in transgenic mice. (1985) (76)
Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis (2016) (74)
Transfer of a yeast artificial chromosome carrying human DNA from Saccharomyces cerevisiae into mammalian cells. (1990) (73)
Domains of axin and disheveled required for interaction and function in wnt signaling. (2000) (73)
Twist1 activity thresholds define multiple functions in limb development. (2010) (70)
Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. (2005) (69)
The transcription factors Etv4 and Etv5 mediate formation of the ureteric bud tip domain during kidney development (2010) (68)
H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo. (1991) (63)
Repetitive sequence transcripts in the mature sea urchin oocyte (1978) (63)
Faculty Opinions recommendation of Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts. (2002) (63)
Actin Depolymerizing Factors Cofilin1 and Destrin Are Required for Ureteric Bud Branching Morphogenesis (2010) (62)
RET‐deficient mice: an animal model for Hirschsprung's disease and renal agenesis (1995) (61)
Mitogen-Activated Protein Kinase (MAPK) Pathway Regulates Branching by Remodeling Epithelial Cell Adhesion (2014) (60)
Impaired neural development caused by inducible expression of Axin in transgenic mice (2007) (60)
A transgenic mouse that reveals cell shape and arrangement during ureteric bud branching (2009) (60)
Ectopic Expression of Axin Blocks Neuronal Differentiation of Embryonic Carcinoma P19 Cells* (2003) (52)
Insertional mutations in transgenic mice. (1989) (51)
Second generation knockout sickle mice: the effect of HbF. (2001) (51)
SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability (2008) (50)
A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. (1999) (49)
Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction (2005) (49)
ETS-related Transcription Factors ETV4 and ETV5 Are Involved in Proliferation and Induction of Differentiation-associated Genes in Embryonic Stem (ES) Cells* (2015) (48)
Increased expression of laminin-1 and collagen (IV) subunits in the aganglionic bowel of ls/ls, but not c-ret -/- mice. (1996) (48)
Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension. (2014) (46)
Upstream G gamma-globin and downstream beta-globin sequences required for stage-specific expression in transgenic mice (1987) (43)
Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin* (2004) (42)
Isolation and characterization of a chicken homolog of the c-ret proto-oncogene. (1995) (41)
A Shortened Life Span of EKLF−/− Adult Erythrocytes, Due to a Deficiency of β-Globin Chains, Is Ameliorated by Human γ-Globin Chains (1997) (38)
Downregulation of Wnt/β-catenin signaling causes degeneration of hippocampal neurons in vivo (2011) (31)
Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling. (2009) (30)
Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged Mu heavy chain gene (1986) (28)
The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney. (2011) (26)
Locus control region-A gamma transgenic mice: a new model for studying the induction of fetal hemoglobin in the adult. (1991) (26)
Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice (1989) (25)
A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains. (1997) (24)
Magnetic resonance evidence of hypoxia in a homozygous alpha-knockout of a transgenic mouse model for sickle cell disease. (1996) (23)
Evolutionary conservation of repetitive sequence expression in sea urchin egg RNA's. (1980) (22)
FGF8 is essential for formation of the ductal system in the male reproductive tract (2011) (21)
Dissection of embryonic mouse kidney, culture in vitro, and imaging of the developing organ. (2011) (21)
Roles of fetal G gamma-globin promoter elements and the adult beta-globin 3' enhancer in the stage-specific expression of globin genes (1990) (21)
Tissue-specific and hormonally regulated expression of a rat alpha 2u globulin gene in transgenic mice (1987) (21)
Locus control region-A gamma transgenic mice: a new model for studying the induction of fetal hemoglobin in the adult (1991) (20)
K:CI cotransport in red cells of transgenic mice expressing high levels of human hemoglobin S (1997) (20)
Developmental regulation of a cloned adult beta-globin gene in transgenic mice. (1985) (20)
Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme (2014) (19)
Retraction: Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged Mu heavy chain gene (1991) (19)
YAC transgenesis: a study of conditions to protect YAC DNA from breakage and a protocol for transfection. (1998) (18)
Silent genes in the mouse major urinary protein gene family. (1989) (18)
Genetic manipulation of the early mammalian embryo (1985) (18)
Use of embryonic stem cells to study mutations affecting postimplantation development in the mouse. (1992) (17)
Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis (2009) (17)
Faculty Opinions recommendation of GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. (2004) (15)
Gene transfer into the mouse germ‐line (1982) (15)
Imaging kidney development. (2011) (14)
Mosaic analysis of cell rearrangements during ureteric bud branching in dissociated/reaggregated kidney cultures and in vivo (2016) (14)
Developmentally distinct effects on human ε-, γ- and δ-globin levels caused by the absence or altered position of the human β-globin gene in YAC transgenic mice (2000) (13)
Lentiviral vector-mediated gene transfer in embryonic stem cells. (2006) (13)
Erratum: Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis (2010) (13)
Functional Analysis of IL‐6 and IL‐6DBP/C/EBPβ by Gene Targeting (1995) (12)
Morula decompaction (mdn), a preimplantation recessive lethal defect in a transgenic mouse line. (1993) (11)
Identification of an enhancer required for the expression of a mouse major urinary protein gene in the submaxillary gland. (1991) (11)
Analysis of the developmental and transcriptional potentiation functions of 5'HS2 of the murine beta-globin locus control region in transgenic mice. (1994) (11)
Control of VDJ recombinase activity. (1989) (10)
High expression of human pBs and a-globins in transgenic mice: Hemoglobin composition and hematological consequences (10)
Unusual inheritance of the AxinFu mutation in mice is associated with widespread rearrangements in the proximal region of chromosome 17. (2000) (9)
Dispensable role of protein 4.1B/DAL-1 in rodent adrenal medulla regarding generation of pheochromocytoma and plasmalemmal localization of TSLC1. (2009) (9)
Developmentally distinct effects on human epsilon-, gamma- and delta-globin levels caused by the absence or altered position of the human beta-globin gene in YAC transgenic mice. (2000) (8)
Tissue-specific DNase I hypersensitive sites in a foreign globin gene in transgenic mice. (1986) (8)
Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF (2021) (7)
Developmental mosaicism may explain spontaneous reappearance of the AxinFu mutation in mice (2001) (6)
Functional analysis of IL-6 and IL-6DBP/C/EBP beta by gene targeting. (1995) (5)
Tissue- and stage-specific expression of a cloned adult beta globin gene in transgenic mice. (1985) (4)
FGF 8 is essential for formation of the ductal system in the male reproductive tract (4)
Structure and expression of foreign globin genes in transgenic mice. (1983) (4)
Roles of Fetal G-yGlobin Promoter Elements and the Adult 3-Globin 3' Enhancer in the Stage-Specific Expression of Globin Genes (2003) (4)
Chapter 4 – RET Signaling in Ureteric Bud Formation and Branching (2016) (4)
Expression of normal, mutant and hybrid human globin genes in transgenic mice. (1987) (3)
Position Effects and Gene Expression in the Transgenic Mouse (1984) (3)
Ret signaling in ureteric bud epithelial cells controls cell movements, cell clustering and bud formation. (2021) (3)
Huddling behavior of spiny mouse pups toward foster siblings from another species (1983) (2)
Analysis of human gamma and beta globin gene regulation using transgenic mice. (1989) (2)
Analysis of Human γ‐To‐β Switching in Transgenic Mice a (1990) (2)
ETV4 Mutation in a Patient with Congenital Anomalies of the Kidney and Urinary Tract (2016) (2)
A transgenic mouse model for studying the induction of fetal hemoglobin in the adult. (1990) (2)
Locomotor activity in juvenile Norway rats as a function of amount of filial huddling at 5-9 days of age (1982) (1)
Imaging tools for analysis of the ureteric tree in the developing mouse kidney. (2014) (1)
patterns during cardiac development Three-dimensional reconstruction of gene expression (2015) (1)
AUTONOMOUS AND COMPETITIVE MECHANISMS OF HUMAN HEMOGLOBIN SWITCHING (1991) (1)
Sproutyl is a critical regulator of kidney development by antagonizing GDNF/Ret-mediated signals during ureteric bud morphogenesis (2005) (1)
14 – Role of Transcription Factor GATA-1 in the Differentiation of Hemopoietic Cells (1993) (1)
Faculty Opinions recommendation of Identification of pleiotrophin as a mesenchymal factor involved in ureteric bud branching morphogenesis. (2001) (1)
Studies of repetitive sequence transcripts in the sea urchin (1980) (1)
Generating Genetic Mosaic Mouse Embryos or Organoids for Studies of Kidney Development. (2019) (1)
Acquisition of leverpress shock avoidance in juvenile Norway rats and spiny mice (1981) (1)
INITIAL STUDIES OF SEA URCHIN DNA SEQUENCE ORGANIZATION BY MOLECULAR CLONING (1976) (1)
Faculty Opinions recommendation of Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. (2001) (1)
Long‐term high‐level expression of human β‐globin occurs following transplantation of transgenic marrow into irradiated mice (1993) (1)
The RGS domain and the six C-terminal amino acids of mouse Axin are both required for normal embryogenesis (2009) (1)
studying the induction of fetal hemoglobin in the adult Locus control region-A gamma transgenic mice: a new model for (2011) (0)
Gata3 and its role in urogenital system development (2008) (0)
O28. Control of branching morphogenesis during kidney development (2010) (0)
Transfer of Yeast Artificial Chromosomes into Cultured Cells: A New Method for Manipulating the Mammalian Genome (1992) (0)
Transgenic Mouse Model of Sickle Cell Disease (2007) (0)
Faculty Opinions recommendation of Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. (2004) (0)
Acknowledgement to reviewers (2004) (0)
Program/Abstract # 118Identifying genes involved in ureteric bud morphogenesis (2011) (0)
RolesofFetalG-yGlobin Promoter Elements andtheAdult3-Globin 3'Enhancer intheStage-Specific Expression ofGlobin Genes (1990) (0)
Faculty Opinions recommendation of NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons. (2002) (0)
Tumor-free elongation of mammalian nephrogenesis by excess fetal GDNF (2020) (0)
Rapid Publication Magnetic Resonance Evidence of Hypoxia in a Homozygous Alpha-Knockout of a Transgenic Mouse Model for Sickle Cell Disease (2013) (0)
MOLECULAR CONTROL OF HUMAN FETAL TO ADULT GLOBIN GENE SWITCHING (1990) (0)
The fate of Ret-expressing cells in the kidney and their role in maintaining renal branching morphogenesis (2011) (0)
S08-02 Control of branching morphogenesis during kidney development (2009) (0)
Identification of an enhancer required for the expression of a mouse major urinary protein gene in the submaxillary gland (1991) (0)
Studies of immunodifferentiation using transgenic mice. (1985) (0)
Program/Abstract # 186Fgf8 is essential for development of the male reproductive tract (2009) (0)
Transgenic mouse lines expressing fl uorescent proteins in developing kidney (2011) (0)
Topic Introduction Imaging Kidney Development (2011) (0)
Expression of a silent MUP gene in transgenic mice. (1991) (0)
Faculty Opinions recommendation of Social interactions among epithelial cells during tracheal branching morphogenesis. (2006) (0)
Faculty Opinions recommendation of Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. (2005) (0)
Faculty Opinions recommendation of Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. (2004) (0)
P87. Actin depolymerizing factors Cfl1 and Dstn are required for ureteric bud branching morphogenesis (2010) (0)
13-P066 SPROUTY1 and RTK signaling in kidney development (2009) (0)
The novel ras/MAPK antagonist, Sprouty1, is essential for normal renal development (2004) (0)
[TECHNIC FOR PERFUSION OF THE RABBIT KIDNEY IN SITU AND PRELIMINARY RESULTS ON THE RATIO OF REABSORBED SODIUM AND CONSUMED' OXYGEN]. (1963) (0)
Faculty Opinions recommendation of Individual cell migration serves as the driving force for optic vesicle evagination. (2006) (0)
Identification and characterization of Etv4/5 target genes during ureteric bud branching morphogenesis (2011) (0)
S-4-4 Role of Ret/GDNF in branching morphogenesis of the ureteric bud (2002) (0)

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