Frank J. Gonzalez

Frank J. Gonzalez's AcademicInfluence.com Rankings

Frank J. Gonzalez

Biology

#1284

World Rank

#2177

Historical Rank

Molecular Biology

#76

World Rank

#78

Historical Rank

biology Degrees

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Biology

Frank J. Gonzalez's Degrees

PhD Molecular Biology Stanford University

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Frank J. Gonzalez's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators (1995) (1691)
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. (1993) (1640)
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis (2000) (1590)
P450 genes: structure, evolution, and regulation. (1987) (1576)
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia* (2008) (1498)
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting (1999) (1433)
The PPARα–leukotriene B4 pathway to inflammation control (1996) (1321)
The molecular biology of cytochrome P450s. (1988) (1283)
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. (2002) (1248)
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. (1996) (1167)
Cytochrome P450 (1993) (1119)
Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer* (2004) (1114)
Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis (2001) (1058)
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. (1991) (1056)
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006) (946)
Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1* (1999) (917)
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. (2006) (846)
Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. (1996) (834)
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. (1999) (801)
Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)* (1998) (794)
The P450 gene superfamily: recommended nomenclature. (1987) (774)
Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass* (2003) (720)
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism (1988) (714)
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. (2000) (711)
Growth, Adipose, Brain, and Skin Alterations Resulting from Targeted Disruption of the Mouse Peroxisome Proliferator-Activated Receptor β(δ) (2000) (707)
Role of CYP2E1 in the Hepatotoxicity of Acetaminophen (*) (1996) (621)
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. (1992) (594)
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. (2003) (566)
Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. (1989) (566)
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. (1989) (552)
cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. (1993) (539)
Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis (2003) (535)
Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene* (2000) (534)
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity (2013) (532)
Adipocyte-specific Gene Expression and Adipogenic Steatosis in the Mouse Liver Due to Peroxisome Proliferator-activated Receptor γ1 (PPARγ1) Overexpression* (2003) (531)
Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites. (1998) (526)
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9. (1994) (521)
Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. (1994) (518)
Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue* (2011) (517)
The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice* (2006) (517)
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. (1990) (505)
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. (2005) (504)
Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. (1997) (501)
A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR (2002) (498)
Molecular genetics of the P-450 superfamily. (1990) (492)
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. (2007) (489)
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine Published, JLR Papers in Press, August 24, 2007. (2007) (487)
Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner* (1998) (483)
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin (2018) (471)
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. (2015) (465)
The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4 (2003) (460)
Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice* (1997) (456)
Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes (2005) (447)
PPARδ regulates glucose metabolism and insulin sensitivity (2006) (447)
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. (2003) (437)
A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice. (1998) (431)
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. (1989) (428)
Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism (2001) (426)
Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. (1994) (424)
Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8. (1994) (421)
The PPARalpha-leukotriene B4 pathway to inflammation control. (1996) (418)
Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR)α and PPARβ mutant mice (2001) (410)
Nomenclature for human CYP2D6 alleles. (1996) (409)
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. (1986) (403)
Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. (1993) (399)
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. (1990) (396)
Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450* (2001) (392)
Conditional Disruption of the Peroxisome Proliferator-Activated Receptor γ Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholesterol Efflux (2002) (390)
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention (2012) (385)
The aryl hydrocarbon receptor: studies using the AHR-null mice. (1998) (383)
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas. (1999) (380)
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction (2015) (379)
Human cytochromes P450: problems and prospects. (1992) (369)
PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages (2003) (366)
Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). (1998) (364)
Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. (2009) (363)
CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity (2000) (362)
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. (1996) (357)
Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site. (1994) (356)
The Farnesoid X-receptor Is an Essential Regulator of Cholesterol Homeostasis* (2003) (349)
Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. (2010) (343)
Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease (2004) (341)
Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation* (2000) (340)
Lesions of Aryl-hydrocarbon Receptor–deficient Mice (1997) (334)
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. (1991) (334)
Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice. (1999) (332)
Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity* (2000) (320)
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. (2007) (316)
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR (2004) (312)
Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. (2001) (312)
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. (2008) (311)
Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention. (2005) (308)
Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1. (1992) (305)
APC-dependent suppression of colon carcinogenesis by PPARγ (2002) (298)
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. (1998) (296)
Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity* (2003) (295)
Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. (2003) (293)
Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy. (1995) (289)
C/EBP induces adipogenesis through PPAR: a unified pathway (2002) (285)
Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism (2018) (284)
FXR signaling in the enterohepatic system (2013) (284)
Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation (1986) (284)
Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family. (1987) (283)
A chemical-genetic approach to study G protein regulation of β cell function in vivo (2009) (283)
Mechanism of Action of the Nongenotoxic Peroxisome Proliferators: Role of the Peroxisome Proliferator-Activated Receptor α (1998) (282)
Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. (2013) (279)
Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization. (1989) (279)
Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4 (1989) (276)
Peroxisome Proliferator-Activated Receptor α Regulates a MicroRNA-Mediated Signaling Cascade Responsible for Hepatocellular Proliferation (2007) (272)
Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. (1996) (271)
Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. (1994) (271)
Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome (2019) (270)
Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota. (2017) (270)
METABOLISM OF MELATONIN BY HUMAN CYTOCHROMES P450 (2005) (268)
Plasticity and expanding complexity of the hepatic transcription factor network during liver development. (2006) (268)
Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity (2011) (267)
Polyunsaturated Fatty Acid Suppression of Hepatic Fatty Acid Synthase and S14 Gene Expression Does Not Require Peroxisome Proliferator-activated Receptor α* (1997) (266)
Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation. (1997) (264)
PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. (2008) (263)
Laron Dwarfism and Non-Insulin-Dependent Diabetes Mellitus in the Hnf-1α Knockout Mouse (1998) (263)
Receptor and Nonreceptor-Mediated Organ-Specific Toxicity of Di(2-ethylhexyl)phthalate (DEHP) in Peroxisome Proliferator-Activated Receptorα-Null Mice (1998) (261)
The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR). (2006) (260)
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. (2003) (260)
Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. (2003) (258)
Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice (2011) (256)
Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. (2003) (254)
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1. (1990) (254)
The role of Kupffer cell oxidant production in early ethanol-induced liver disease. (2001) (248)
Glucocorticoid signaling synchronizes the liver circadian transcriptome (2007) (245)
A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. (1991) (241)
C/EBPα Regulates Hepatic Transcription of Hepcidin, an Antimicrobial Peptide and Regulator of Iron Metabolism (2002) (238)
Liver Receptor Homologue-1 Mediates Species- and Cell Line-specific Bile Acid-dependent Negative Feedback Regulation of the Apical Sodium-dependent Bile Acid Transporter* (2003) (236)
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. (2005) (236)
Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling. (2011) (232)
Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1. (2008) (231)
Modification of Ocular Defects in Mouse Developmental Glaucoma Models by Tyrosinase (2003) (230)
Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner. (1998) (229)
The induction of a specific form of cytochrome P-450 (P-450j) by fasting. (1987) (227)
Persistent Organic Pollutants Modify Gut Microbiota–Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation (2015) (226)
Enzymatic mechanisms of ethanol oxidation in the brain. (2006) (225)
Peroxisome proliferator-activated receptor-α and liver cancer: where do we stand? (2005) (225)
Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines: CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate (2006) (225)
Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice. (1999) (224)
The Farnesoid X Receptor Modulates Hepatic Carbohydrate Metabolism during the Fasting-Refeeding Transition* (2005) (224)
PPARdelta regulates glucose metabolism and insulin sensitivity. (2006) (224)
Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. (1990) (222)
LC-MS-Based Metabolomics in Drug Metabolism (2007) (220)
Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines. (1997) (216)
Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. (1985) (215)
Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. (1988) (215)
Diminished Hepatocellular Proliferation in Mice Humanized for the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (2004) (214)
Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat. (1987) (209)
A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. (2010) (209)
PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance (2001) (208)
Defective Brain Development in Mice Lacking the Hif-1α Gene in Neural Cells (2003) (207)
The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins. (1990) (207)
PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver. (2011) (206)
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis (2012) (206)
PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. (2008) (206)
An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease. (2016) (206)
Dual farnesoid X receptor/TGR5 agonist INT‐767 reduces liver injury in the Mdr2−/− (Abcb4−/−) mouse cholangiopathy model by promoting biliary HCO 3− output (2011) (205)
Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression. (1996) (205)
Peroxisomal and Mitochondrial Fatty Acid β-Oxidation in Mice Nullizygous for Both Peroxisome Proliferator-activated Receptor α and Peroxisomal Fatty Acyl-CoA Oxidase (1999) (204)
Targeted Disruption of the Microsomal Epoxide Hydrolase Gene (1999) (202)
Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. (2011) (201)
Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota. (2017) (201)
Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. (2004) (199)
Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. (1988) (199)
The role of hypoxia-inducible factors in metabolic diseases (2018) (198)
Challenges and opportunities of metabolomics (2012) (197)
Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. (2012) (196)
Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. (2004) (196)
Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development (2009) (195)
Disruption of the c/ebp alpha gene in adult mouse liver (1997) (193)
Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis. (2017) (192)
Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. (2010) (191)
Transcriptional regulation of rat liver epoxide hydratase, NADPH-Cytochrome P-450 oxidoreductase, and cytochrome P-450b genes by phenobarbital. (1983) (190)
Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver. (1998) (188)
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. (2007) (186)
Loss of the Peroxisome Proliferation-activated Receptor gamma (PPARγ) Does Not Affect Mammary Development and Propensity for Tumor Formation but Leads to Reduced Fertility* (2002) (186)
Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. (2003) (186)
Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis. (1998) (186)
Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression (2007) (183)
Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans[S] (2016) (183)
The 2006 Bernard B. Brodie Award Lecture. Cyp2e1. (2006) (182)
Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice. (2009) (180)
Xenobiotic metabolomics: major impact on the metabolome. (2012) (180)
Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis. (2006) (179)
Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. (2003) (179)
Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice* (2012) (178)
Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool (2019) (176)
Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues (1986) (176)
Peroxisome proliferator activated receptor γ in colonic epithelial cells protects against experimental inflammatory bowel disease (2005) (176)
Role of CYP1B1 in glaucoma. (2008) (175)
The peroxisome proliferator‐activated receptor α regulates amino acid metabolism (2001) (175)
PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice (2020) (175)
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection (2008) (174)
Characterization of the human dihydropyrimidine dehydrogenase gene. (1998) (172)
Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. (2007) (172)
Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice. (2001) (169)
Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues. (1995) (169)
Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. (2009) (169)
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil. (1999) (167)
Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. (2004) (166)
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. (1989) (166)
O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. (1994) (164)
Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast. (2000) (161)
Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha. (1999) (160)
The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site. (1990) (160)
The Coactivator PGC-1 Is Involved in the Regulation of the Liver Carnitine Palmitoyltransferase I Gene Expression by cAMP in Combination with HNF4α and cAMP-response Element-binding Protein (CREB)* (2002) (160)
THE CYP2E1-HUMANIZED TRANSGENIC MOUSE: ROLE OF CYP2E1 IN ACETAMINOPHEN HEPATOTOXICITY (2005) (160)
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. (1988) (160)
The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse. (2001) (160)
Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. (1998) (160)
Regulation of Hepatocyte Nuclear Factor 4α-mediated Transcription (2008) (159)
Pharmacogenetic Phenotyping and Genotyping (1994) (159)
The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis. (1998) (159)
The role of 12 cDNA‐expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans‐7, 8‐dihydrodiol (1994) (157)
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. (2008) (157)
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. (1988) (157)
The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. (1984) (156)
Targeting nuclear receptors for the treatment of fatty liver disease (2017) (156)
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. (2008) (155)
Peroxisome proliferator–activated receptor-δ attenuates colon carcinogenesis (2004) (155)
Peroxisome proliferator‐activated receptor α protects against alcohol‐induced liver damage (2004) (154)
Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol‐induced oxidative DNA damage in rodent liver (2005) (154)
Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. (1985) (153)
CYP2E1 is not involved in early alcohol-induced liver injury. (1999) (152)
PPARβ/δ selectively induces differentiation and inhibits cell proliferation (2006) (152)
CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. (2013) (152)
Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis. (2006) (151)
Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid. (1997) (151)
Hypoxia‐inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis (2011) (151)
Cytochrome P450 and xenobiotic receptor humanized mice. (2006) (151)
Hypersensitivity of Aryl Hydrocarbon Receptor-Deficient Mice to Lipopolysaccharide-Induced Septic Shock (2009) (150)
Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism. (1993) (150)
Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model (2010) (149)
Radiation Metabolomics. 1. Identification of Minimally Invasive Urine Biomarkers for Gamma-Radiation Exposure in Mice (2008) (149)
Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. (1991) (149)
Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. (2015) (149)
Protective Role of Hydroxysteroid Sulfotransferase in Lithocholic Acid-induced Liver Toxicity* (2003) (148)
The role of peroxisome proliferator-activated receptor-β/δ in epithelial cell growth and differentiation (2006) (148)
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol. (2001) (148)
The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3. (1991) (147)
The PPARα-Humanized Mouse: A Model to Investigate Species Differences in Liver Toxicity Mediated by PPARα (2008) (146)
Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation (2010) (145)
Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats. (1988) (144)
A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse. (2006) (144)
A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing. (1991) (144)
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism (2017) (144)
Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene. (1984) (142)
Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. (2000) (142)
The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domain (1997) (142)
PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. (2008) (142)
The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants. (2000) (141)
UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. (2008) (141)
The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition (2016) (141)
Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea. (1995) (141)
Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. (1987) (140)
The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria. (2009) (140)
Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450 (2000) (140)
Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. (2000) (139)
Mechanism of 7,12-dimethylbenz[a]anthracene-induced immunotoxicity: role of metabolic activation at the target organ. (2001) (139)
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. (1985) (139)
Role of the hepatocyte nuclear factor 4α in control of the pregnane X receptor during fetal liver development (2003) (138)
FXR regulates organic solute transporters α and β in the adrenal gland, kidney, and intestine Published, JLR Papers in Press, October 26, 2005. (2006) (137)
Estrogen Receptor α Mediates 17α-Ethynylestradiol Causing Hepatotoxicity* (2006) (137)
Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate. (1996) (137)
DNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment. (1991) (137)
Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P1(450) gene. (1985) (137)
The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes. (1989) (137)
The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPARα-Dependent Mechanisms (2009) (137)
Etomoxir-induced PPARα-modulated enzymes protect during acute renal failure (2000) (135)
Hepatocyte Nuclear Factor 4α, a Key Factor for Homeostasis, Cell Architecture, and Barrier Function of the Adult Intestinal Epithelium (2009) (135)
Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism. (1997) (135)
The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation. (1988) (135)
Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s. (1990) (134)
PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis. (2004) (134)
Targeted Elimination of Peroxisome Proliferator-Activated Receptor γ in β Cells Leads to Abnormalities in Islet Mass without Compromising Glucose Homeostasis (2003) (134)
Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition (2012) (133)
Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques. (1993) (133)
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co–therapy (2013) (132)
Constitutive expression of hepatic cytochrome P450 genes (1996) (132)
The Pregnane X Receptor Gene-Humanized Mouse: A Model for Investigating Drug-Drug Interactions Mediated by Cytochromes P450 3A (2007) (132)
Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse liver. (2008) (132)
Cytochromes P450 Expression Systems (1995) (132)
Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1 (1991) (132)
Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk Assessment (2008) (131)
Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. (1996) (131)
An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice (2016) (131)
Overproduction of VEGF concomitantly expressed with its receptors promotes growth and survival of melanoma cells through MAPK and PI3K signaling. (2004) (130)
Hepatocyte nuclear factor 4&agr; in the intestinal epithelial cells protects against inflammatory bowel disease (2008) (129)
Polymorphic Cytochrome P450 2D6: Humanized Mouse Model and Endogenous Substrates (2004) (129)
Molecular genetics of the debrisoquin‐sparteine polymorphism (1991) (129)
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells. (1992) (128)
Hepatocyte Nuclear Factor-4α Is Essential for Glucose-stimulated Insulin Secretion by Pancreatic β-Cells* (2006) (127)
Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. (1991) (127)
cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria. (1994) (127)
Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. (2001) (126)
Defective brain development in mice lacking the Hif-1alpha gene in neural cells. (2003) (126)
CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice: correlation of CYP1B1-mediated DNA adducts with carcinogenicity. (2003) (125)
Pregnane X receptor as a target for treatment of inflammatory bowel disorders. (2012) (125)
Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs. (1996) (125)
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. (1994) (125)
Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer. (2014) (125)
The role of the peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac lipid metabolism (1999) (124)
Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects. (1998) (123)
Identification of Novel Toxicity-associated Metabolites by Metabolomics and Mass Isotopomer Analysis of Acetaminophen Metabolism in Wild-type and Cyp2e1-null Mice* (2008) (123)
A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor (1994) (122)
Regulation of Constitutive Androstane Receptor and Its Target Genes by Fasting, cAMP, Hepatocyte Nuclear Factor α, and the Coactivator Peroxisome Proliferator-activated Receptor γ Coactivator-1α* (2006) (122)
Regulation of Human ApoA-I by Gemfibrozil and Fenofibrate Through Selective Peroxisome Proliferator–Activated Receptor &agr; Modulation (2005) (122)
Reduced Adiposity and Liver Steatosis by Stearoyl-CoA Desaturase Deficiency Are Independent of Peroxisome Proliferator-activated Receptor-α* (2004) (122)
The pregnane X receptor: from bench to bedside (2008) (121)
Role of human hepatic cytochrome P450 1A2 and 3A4 in the metabolic activation of estrone. (1997) (121)
Effects of FXR in foam-cell formation and atherosclerosis development. (2006) (121)
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. (2005) (121)
Hyalinosis and Ym1/Ym2 gene expression in the stomach and respiratory tract of 129S4/SvJae and wild-type and CYP1A2-null B6, 129 mice. (2001) (120)
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. (2003) (119)
Role of peroxisome proliferator-activated receptor-α (PPARα) in bezafibrate-induced hepatocarcinogenesis and cholestasis (2004) (119)
Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. (2003) (118)
Di(2‐ethylhexyl)phthalate Induces Hepatic Tumorigenesis through a Peroxisome Proliferator‐activated Receptor α‐independent Pathway (2007) (118)
Characterization of cytochrome P-450 2B6 in human liver microsomes. (1993) (118)
Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis. (2007) (118)
On the mechanism for PPAR agonists to enhance ABCA1 gene expression. (2009) (118)
Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity (2009) (118)
Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping. (1989) (117)
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. (2006) (116)
Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. (2007) (116)
Contribution of Individual Cytochrome P450 Isozymes to theO-Demethylation of the Psychotropic β-Carboline Alkaloids Harmaline and Harmine (2003) (116)
The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element. (1989) (116)
PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance. (2001) (116)
Hepatocyte Nuclear Factor 4α Coordinates a Transcription Factor Network Regulating Hepatic Fatty Acid Metabolism (2009) (115)
Peroxisome Proliferator-activated Receptor-α Regulates Lipid Homeostasis, but Is Not Associated with Obesity (2001) (115)
Transcription Coactivator PBP, the Peroxisome Proliferator-activated Receptor (PPAR)-binding Protein, Is Required for PPARα-regulated Gene Expression in Liver* (2004) (115)
Enhanced acetaminophen toxicity by activation of the pregnane X receptor. (2004) (114)
Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha. (1998) (113)
Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. (2003) (112)
Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α. (2013) (112)
PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis (2014) (112)
HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice. (2015) (111)
Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1. (1995) (111)
Sumoylation of Peroxisome Proliferator-Activated Receptor γ by Apoptotic Cells Prevents Lipopolysaccharide-Induced NCoR Removal from κB Binding Sites Mediating Transrepression of Proinflammatory Cytokines1 (2008) (110)
Rifaximin Is a Gut-Specific Human Pregnane X Receptor Activator (2007) (109)
Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. (2012) (109)
Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms. (1993) (108)
Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators. (2000) (108)
The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α (2011) (107)
Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity. (2008) (106)
Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells (2013) (106)
Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. (2004) (105)
The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. (1989) (105)
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene. (2000) (105)
Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease. (2008) (105)
C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. (2002) (104)
Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans. (2015) (104)
Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells. (1999) (104)
Regulation of cytochrome P450 genes: molecular mechanisms. (1993) (104)
Study of P450 function using gene knockout and transgenic mice. (2003) (104)
Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice (2016) (103)
The 2006 Bernard B . Brodie Award Lecture CYP 2 E 1 (2006) (103)
Radiation Metabolomics. 2. Dose- and Time-Dependent Urinary Excretion of Deaminated Purines and Pyrimidines after Sublethal Gamma-Radiation Exposure in Mice (2009) (103)
Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. (2006) (102)
Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet. (2015) (102)
Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2. (1995) (102)
Caffeine as a probe for human cytochromes P450: validation using cDNA-expression, immunoinhibition and microsomal kinetic and inhibitor techniques. (1992) (101)
Hypoxia-Inducible Factor Directs POMC Gene to Mediate Hypothalamic Glucose Sensing and Energy Balance Regulation (2011) (101)
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2. (2005) (100)
Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. (1999) (100)
Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen. (1995) (100)
Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia* (2009) (99)
Farnesoid X receptor represses hepatic human APOA gene expression. (2011) (99)
PPARγ in endothelial cells influences high fat diet-induced hypertension (2005) (99)
Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease. (2006) (99)
The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis. (1995) (98)
Cooperative Interaction between Hepatocyte Nuclear Factor 4α and GATA Transcription Factors Regulates ATP-Binding Cassette Sterol Transporters ABCG5 and ABCG8 (2007) (98)
Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones. (2003) (97)
Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. (1994) (96)
Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the omega- and (omega-1)-hydroxylation of fatty acids and the omega-hydroxylation of prostaglandins E1 and F2 alpha. (1990) (96)
Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP (2015) (96)
Epithelial cell PPARγ contributes to normal lung maturation (2006) (96)
A Common Regulatory Region Functions Bidirectionally in Transcriptional Activation of the Human CYP1A1 and CYP1A2 Genes (2006) (96)
The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. (1990) (96)
Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer. (1998) (95)
Peroxisome Proliferator-activated Receptor β/δ Regulates Very Low Density Lipoprotein Production and Catabolism in Mice on a Western Diet* (2004) (95)
Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene. (1995) (95)
Stereoselective epoxidation and hydration at the K-region of polycyclic aromatic hydrocarbons by cDNA-expressed cytochromes P450 1A1, 1A2, and epoxide hydrolase. (1996) (95)
Radiation Metabolomics. 3. Biomarker Discovery in the Urine of Gamma-Irradiated Rats Using a Simplified Metabolomics Protocol of Gas Chromatography-Mass Spectrometry Combined with Random Forests Machine Learning Algorithm (2009) (95)
Sorting out the functional role(s) of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in cell proliferation and cancer. (2009) (95)
Recent update on the PPARα-null mouse (1997) (94)
Radiation Metabolomics. 4. UPLC-ESI-QTOFMS-Based Metabolomics for Urinary Biomarker Discovery in Gamma-Irradiated Rats (2011) (94)
Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells. (2001) (94)
FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. (2006) (94)
Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription. (2008) (94)
Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. (2007) (94)
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation. (2002) (93)
Potential role of CYP1B1 in the development and treatment of metabolic diseases (2017) (93)
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer (2021) (93)
Peroxisome Proliferator-activated Receptor β (δ)-dependent Regulation of Ubiquitin C Expression Contributes to Attenuation of Skin Carcinogenesis* (2004) (92)
Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene. (1987) (92)
Nomenclature for human DPYD alleles. (1998) (92)
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis (2017) (91)
Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization. (1988) (91)
Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7. (1989) (91)
Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation (2017) (91)
Piperonyl butoxide and acenaphthylene induce cytochrome P450 1A2 and 1B1 mRNA in aromatic hydrocarbon-responsive receptor knock-out mouse liver. (1996) (91)
Transient impairment of the adaptive response to fasting in FXR‐deficient mice (2005) (90)
Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. (1993) (90)
Growth Hormone Determines Sexual Dimorphism of Hepatic Cytochrome P450 3A4 Expression in Transgenic Mice (2006) (90)
FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. (2017) (89)
Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value (2015) (89)
Transcriptional control of the rat hepatic CYP2E1 gene (1990) (89)
Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. (2006) (88)
Peroxisome Proliferator-activated Receptor-β/δ Inhibits Epidermal Cell Proliferation by Down-regulation of Kinase Activity* (2005) (87)
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning (2012) (87)
Ligand activation of peroxisome proliferator-activated receptor-β/δ(PPARβ/δ) inhibits cell growth of human N/TERT-1 keratinocytes (2007) (87)
Herbal drug discovery for the treatment of nonalcoholic fatty liver disease (2019) (87)
Bezafibrate is a dual ligand for PPARα and PPARβ: studies using null mice (2003) (87)
Peroxisome proliferator‐activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen‐induced liver toxicity (2012) (87)
Hypoxia Inducible Factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis (2011) (86)
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. (2003) (86)
Transgenic animal models in toxicology: historical perspectives and future outlook. (2011) (86)
Radiation Metabolomics. 5. Identification of Urinary Biomarkers of Ionizing Radiation Exposure in Nonhuman Primates by Mass Spectrometry-Based Metabolomics (2012) (86)
Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene. (1989) (86)
Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding. (1996) (85)
Di(2-ethylhexyl) phthalate induces a functional zinc deficiency during pregnancy and teratogenesis that is independent of peroxisome proliferator-activated receptor-α (1997) (85)
In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase. (1994) (85)
Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand? (2005) (85)
Regulation of the Liver Fatty Acid-binding Protein Gene by Hepatocyte Nuclear Factor 1α (HNF1α) ALTERATIONS IN FATTY ACID HOMEOSTASIS INHNF1α-DEFICIENT MICE (2000) (85)
Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. (2009) (84)
Peroxisome Proliferator-activated Receptor α Is Not Rate-limiting for the Lipoprotein-lowering Action of Fish Oil* (2001) (84)
Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression. (1994) (83)
Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress. (2009) (83)
Acetone catabolism by cytochrome P450 2E1: studies with CYP2E1-null mice. (1999) (82)
Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice (2010) (82)
Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9. (1996) (81)
Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia. (2002) (81)
Effect of Peroxisome Proliferator-Activated Receptor Alpha Activators on Tumor Necrosis Factor Expression in Mice during Endotoxemia (1999) (81)
Characterization of a thyroid-specific enhancer located 5.5 kilobase pairs upstream of the human thyroid peroxidase gene (1990) (81)
Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus. (1989) (81)
Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency. (1995) (81)
cDNA-directed expression of human cytochrome P450 CYP3A4 using baculovirus. (1994) (80)
Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1α/β and DNA Methylation (2006) (80)
Cytochrome P450 gene expression and regulation (1985) (80)
Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15. (1985) (80)
CYP4 isozyme specificity and the relationship between omega-hydroxylation and terminal desaturation of valproic acid. (1995) (80)
Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice. (2010) (80)
Hepatocyte Nuclear Factor 4α Is a Central Regulator of Bile Acid Conjugation* (2004) (80)
Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha. (2006) (80)
Peroxisome proliferator‐activated receptor‐β/δ protects against chemically induced liver toxicity in mice (2007) (80)
Development of Oxidative Stress by Cytochrome P450 Induction in Rodents Is Selective for Barbiturates and Related to Loss of Pyridine Nucleotide-dependent Protective Systems* (2008) (79)
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis. (2001) (79)
Polycyclic aromatic hydrocarbon‐inducible DNA adducts: Evidence by 32P‐postlabeling and use of knockout mice for Ah receptor‐independent mechanisms of metabolic activation in vivo (2003) (79)
Defective Ureagenesis in Mice Carrying a Liver-specific Disruption of Hepatocyte Nuclear Factor 4α (HNF4α) (2002) (79)
Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2. (1996) (79)
Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney. (1993) (79)
Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. (2012) (78)
Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism (2016) (78)
Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism. (1991) (78)
Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA. (1986) (78)
Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity (1989) (77)
Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants. (1996) (77)
Potential role for human cytochrome P450 3A4 in estradiol homeostasis. (2005) (77)
Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice* (2014) (76)
Disruption of Hepatic C/EBPα Results in Impaired Glucose Tolerance and Age-dependent Hepatosteatosis* (2004) (76)
Coactivator PRIP, the Peroxisome Proliferator-activated Receptor-interacting Protein, Is a Modulator of Placental, Cardiac, Hepatic, and Embryonic Development* (2003) (76)
Expression of mammalian cytochrome P450 using vaccinia virus. (1991) (76)
Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice. (2003) (75)
Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. (2010) (75)
Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1. (2003) (75)
Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator–Activated Receptor α (2013) (75)
Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. (2014) (74)
Feedback Inhibition of the Retinaldehyde Dehydrogenase GeneALDH1 by Retinoic Acid through Retinoic Acid Receptor α and CCAAT/Enhancer-binding Protein β* (2000) (74)
Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. (1985) (74)
Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver. (2015) (74)
Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells. (1991) (73)
Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells. (1992) (73)
Activation of Peroxisome Proliferator-activated Receptor α Induces Lysosomal Biogenesis in Brain Cells (2015) (73)
Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms. (1990) (73)
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6. (2019) (73)
Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier (2012) (73)
Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine. (1989) (72)
Rat liver carboxylesterase: cDNA cloning, sequencing, and evidence for a multigene family. (1988) (72)
UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. (2011) (71)
Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice (2011) (71)
Guggulsterone: an old approach to a new problem (2002) (71)
Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice. (2004) (71)
The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. (1999) (71)
Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice* (2013) (71)
CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. (1999) (71)
LC–MS-based metabolomics: an update (2014) (70)
Establishing the Role of PPARβ/δ in Carcinogenesis (2015) (70)
New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production. (2015) (70)
The role of peroxisome proliferator-activated receptor-beta/delta in epithelial cell growth and differentiation. (2006) (70)
The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha. (2008) (69)
Mutagen activation by cDNA‐expressed P1450, P3450, and P450a (1989) (69)
Metabolomics Reveals Attenuation of the SLC6A20 Kidney Transporter in Nonhuman Primate and Mouse Models of Type 2 Diabetes Mellitus* (2011) (69)
Bisphenol A Increases Atherosclerosis in Pregnane X Receptor‐Humanized ApoE Deficient Mice (2014) (69)
Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. (2008) (69)
Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors (2007) (68)
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands do not potentiate growth of human cancer cell lines (2007) (68)
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis[S] (2012) (67)
Xenobiotic metabolism: a view through the metabolometer. (2010) (67)
Human P3450: cDNA and complete amino acid sequence (1986) (67)
The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter Published, JLR Papers in Press, May 7, 2007. (2007) (67)
Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis. (2022) (67)
Different Mechanisms of DEHP‐induced Hepatocellular Adenoma Tumorigenesis in Wild‐type and Pparα‐null Mice (2008) (67)
Hepatic Expression of the UGT1A9 Gene Is Governed by Hepatocyte Nuclear Factor 4α (2005) (67)
Mouse Liver CYP2C39 Is a Novel Retinoic Acid 4-Hydroxylase (2004) (67)
Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. (2008) (66)
Physiological and pathophysiological regulation of cytochrome P450. (1998) (66)
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines (2008) (66)
Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. (2007) (66)
Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19 (1995) (66)
Metabolic activation of the potent carcinogen dibenzo[a,l]pyrene by human recombinant cytochromes P450, lung and liver microsomes. (1996) (66)
The peroxisome proliferator-activated receptor α (PPARα): role in hepatocarcinogenesis (2002) (65)
Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. (2010) (65)
Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. (2005) (65)
Human cytochromes P450: evolution and cDNA-directed expression. (1992) (65)
Hypoxia-inducible Factor 1α Regulates a SOCS3-STAT3-Adiponectin Signal Transduction Pathway in Adipocytes* (2012) (64)
PPARgamma in endothelial cells influences high fat diet-induced hypertension. (2005) (64)
Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system. (1990) (64)
Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease (2017) (64)
A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E). (1987) (63)
Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and Its Role in Polycyclic Aromatic Hydrocarbon-induced Mitochondrial Dysfunction* (2014) (63)
Cytochrome P450 1B1 Contributes to Angiotensin II-Induced Hypertension and Associated Pathophysiology (2010) (63)
Cytochromes P450 expression systems. (1995) (63)
Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary DNA-expressed human liver P-450. (1990) (63)
An HNF4α–microRNA-194/192 signaling axis maintains hepatic cell function (2017) (63)
Role of CYP3A and CYP2E1 in Alcohol-Mediated Increases in Acetaminophen Hepatotoxicity: Comparison of Wild-Type and Cyp2e1(–/–) Mice (2007) (62)
Identification of functions of peroxisome proliferator-activated receptor alpha in proximal tubules. (2002) (62)
A Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4 (2008) (62)
A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach. (2007) (62)
The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases. (2007) (62)
Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms (2008) (62)
Antagonism of the Actions of Peroxisome Proliferator-activated Receptor-α by Bile Acids* (2001) (62)
Ligand Activation of Peroxisome Proliferator-Activated Receptor-β/δ Inhibits Cell Proliferation in Human HaCaT Keratinocytes (2008) (62)
Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor α-Independent Mechanism (2009) (62)
Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice. (2001) (61)
Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. (2005) (61)
Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress. (2009) (61)
Cytochrome P450 Expression and Regulation in CYP3A4/CYP2D6 Double Transgenic Humanized Mice (2008) (61)
Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins. (1996) (61)
PPARbeta/delta selectively induces differentiation and inhibits cell proliferation. (2006) (61)
cDNA and amino acid sequences of two members of the human P450IIC gene subfamily. (1987) (60)
Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA-expressed human, rodent, and rabbit cytochromes P-450. (1994) (60)
Xenobiotic receptor knockout mice. (1995) (60)
A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype. (1996) (60)
Human Peroxisome Proliferator-activated Receptor α (PPARα) Supports the Induction of Peroxisome Proliferation in PPARα-deficient Mouse Liver* (2001) (60)
Expression of mammalian cytochrome P450 using baculovirus. (1991) (60)
Specificity of cDNA‐expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12‐dimethylbenz[a]anthracene (1996) (60)
Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450. (1984) (60)
Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase. (1988) (60)
Over‐production of IFN‐γ and IL‐12 in AhR‐null mice (2005) (60)
Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets (2013) (59)
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis. (2014) (59)
Suppression of mouse hepatocyte apoptosis by peroxisome proliferators : role of PPARα and TNFα (2000) (59)
Nuclear receptor control of enterohepatic circulation. (2012) (59)
Regulation of Tissue-Specific Expression of the Human and Mouse Urate Transporter 1 Gene by Hepatocyte Nuclear Factor 1 α/β and DNA Methylation (2007) (59)
A metabolomic perspective of melatonin metabolism in the mouse. (2008) (59)
Transcriptional Regulation of Human and Mouse Organic Anion Transporter 1 by Hepatocyte Nuclear Factor 1 α/β (2008) (59)
Pioglitazone Increases Macrophage Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Nondiabetic Low-Density Lipoprotein Receptor-Null Mice (2007) (59)
Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse (2008) (59)
Implication of intestinal VDR deficiency in inflammatory bowel disease. (2013) (58)
Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases. (2000) (58)
TNF‐α regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices (2004) (58)
Abcb11 Deficiency Induces Cholestasis Coupled to Impaired β-Fatty Acid Oxidation in Mice* (2012) (58)
The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation (2018) (58)
Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription. (2000) (58)
Urinary Metabolite Profiling Reveals CYP1A2-Mediated Metabolism of NSC686288 (Aminoflavone) (2006) (58)
SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis (2020) (58)
Altered Expression of Small Heterodimer Partner Governs Cytochrome P450 (CYP) 2D6 Induction during Pregnancy in CYP2D6-humanized Mice* (2013) (58)
Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. (2000) (58)
PPARα Protects Proximal Tubular Cells from Acute Fatty Acid Toxicity (2007) (58)
Potential role of CYP2D6 in the central nervous system (2013) (57)
REVERBa couples the circadian clock to hepatic glucocorticoid action (2018) (57)
Selective intranuclear redistribution of PPAR isoforms by RXR alpha. (2002) (57)
Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6. (1993) (57)
Inhibitory monoclonal antibody to human cytochrome P450 2B6. (1998) (57)
Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. (2003) (57)
Phenobarbital induction of NADPH-cytochrome c (P-450) oxidoreductase messenger ribonucleic acid. (1980) (57)
Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes‐Associated Protein Activation in Mice (2018) (57)
Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. (1994) (57)
Tissue-Selective, Bidirectional Regulation of PEX11α and Perilipin Genes through a Common Peroxisome Proliferator Response Element (2004) (57)
Role of Gene Knockout and Transgenic Mice in the Study of Xenobiotic Metabolism (2003) (56)
Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation. (2009) (56)
Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis (2011) (56)
Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation (2014) (56)
In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators (1999) (56)
Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells. (2017) (56)
Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation (2018) (56)
Metabolic map and bioactivation of the anti‐tumour drug noscapine (2012) (56)
Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. (1997) (56)
The role of peroxisome proliferator activated receptor alpha in peroxisome proliferation, physiological homeostasis, and chemical carcinogenesis. (1997) (55)
Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet. (2014) (55)
Inhibitory and non-inhibitory monoclonal antibodies to human cytochrome P450 3A3/4. (1995) (55)
Urinary metabolites and antioxidant products of exogenous melatonin in the mouse (2006) (55)
Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation Published, JLR Papers in Press, January 20, 2009. (2009) (55)
Feedback inhibition of the retinaldehyde dehydrogenase gene ALDH1 by retinoic acid through retinoic acid receptor alpha and CCAAT/enhancer-binding protein beta. (2000) (55)
Modulation of fatty acid and bile acid metabolism by peroxisome proliferator-activated receptor α protects against alcoholic liver disease. (2014) (54)
Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. (2014) (54)
A Role for the Aryl Hydrocarbon Receptor in Regulation of Ischemia-Induced Angiogenesis (2007) (54)
Sequence requirements for cytochrome P-450IID1 catalytic activity. A single amino acid change (Ile380 Phe) specifically decreases Vmax of the enzyme for bufuralol but not debrisoquine hydroxylation. (1990) (54)
Ligand-activated PPARβ efficiently represses the induction of LXR-dependent promoter activity through competition with RXR (2006) (53)
Effects of Fibrate Drugs on Expression of ABCA1 and HDL Biogenesis in Hepatocytes (2008) (53)
Wuzhi Tablet (Schisandra Sphenanthera Extract) Protects against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of NRF2-ARE and p53/p21 Pathways (2014) (53)
Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor α (PPARα) (2000) (53)
Stable expression of human cytochrome P450IA2 cDNA in a human lymphoblastoid cell line: Role of the enzyme in the metabolic activation of aflatoxin B1 (1990) (53)
Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocyclic amines. (1998) (53)
Development of a human lymphoblastoid cell line constitutively expressing human CYP1A1 cDNA: substrate specificity with model substrates and promutagens. (1994) (53)
Schisandrol B protects against cholestatic liver injury through pregnane X receptors (2017) (53)
Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α–Mediated Apoptosis (2016) (53)
Molecular basis of the Dark Agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2. (1998) (52)
Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. (1999) (52)
Peroxisome Proliferator‐Activated Receptor‐γ in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long‐Term Fasting (2013) (52)
Molecular cloning and regulation of expression of two novel mouse CYP4F genes: expression in peroxisome proliferator-activated receptor alpha-deficient mice upon lipopolysaccharide and clofibrate challenges. (2001) (52)
Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. (2010) (52)
An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity. (2014) (52)
Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice. (2003) (52)
The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine (2003) (52)
CYP2E1 and catalase influence ethanol sensitivity in the central nervous system (2006) (52)
Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1. (2008) (52)
Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16 alpha-carbonitrile. Characterization of its mRNA, gene, and induction response. (1983) (52)
Mouse cytochrome P3-450: complete cDNA and amino acid sequence. (1984) (52)
Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice[S] (2014) (52)
Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. (2015) (52)
Evidence for Peroxisome Proliferator-Activated Receptor (PPAR)α-Independent Peroxisome Proliferation: Effects of PPARγ/δ-Specific Agonists in PPARα-Null Mice (2000) (52)
Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. (2007) (51)
Estrogen Metabolism by Cytochrome P450 1B1 Modulates the Hypertensive Effect of Angiotensin II in Female Mice (2014) (51)
Cellular and Pharmacological Selectivity of the Peroxisome Proliferator-Activated Receptor-β/δ Antagonist GSK3787 (2010) (51)
Cytochrome P450 1B1 Contributes to Renal Dysfunction and Damage Caused by Angiotensin II in Mice (2012) (51)
Genetic polymorphism and cancer susceptibility: fourteenth Sapporo Cancer Seminar. (1995) (51)
Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase. (1993) (51)
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls. (1990) (51)
Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29. (2015) (51)
Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam. (1998) (51)
Identification and characterization of PPARα ligands in the hippocampus (2016) (51)
Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice. (2008) (51)
The role of carcinogen-metabolizing enzyme polymorphisms in cancer susceptibility. (1997) (51)
Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPAR-β/δ) Inhibits Human Breast Cancer Cell Line Tumorigenicity (2014) (50)
Assignment of the human dihydropyrimidine dehydrogenase gene (DPYD) to chromosome region 1p22 by fluorescence in situ hybridization. (1994) (50)
Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity. (2013) (50)
Metabolic activation of the pneumotoxin, 3-methylindole, by vaccinia-expressed cytochrome P450s. (1991) (50)
Hepatocyte Nuclear Factor 4α Contributes to Thyroid Hormone Homeostasis by Cooperatively Regulating the Type 1 Iodothyronine Deiodinase Gene with GATA4 and Krüppel-Like Transcription Factor 9 (2008) (50)
Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity. (2005) (50)
Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. (2010) (50)
Quercetin Inhibits Radiation-Induced Skin Fibrosis (2013) (50)
Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics. (2012) (50)
PPAR{alpha} attenuates the proinflammatory response in activated mesangial cells. (2009) (50)
Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis. (2019) (49)
CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively. (1994) (49)
Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3 (2014) (49)
Why toxic equivalency factors are not suitable for perfluoroalkyl chemicals. (2011) (49)
Human liver oxidative metabolism of O6-benzylguanine. (1995) (49)
Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory (2018) (49)
Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity. (2005) (48)
Dioxin-inducible enhancer region upstream from the mouse P(1)450 gene and interaction with a heterologous SV40 promoter. (1986) (48)
Parkinson's disease, pesticides and individual vulnerability. (2004) (48)
PPARβ/δ Protects Against Experimental Colitis Through a Ligand-Independent Mechanism (2007) (48)
Bone marrow stromal cell cytochrome P4501B1 is required for pre-B cell apoptosis induced by 7,12-dimethylbenz[a]anthracene. (1999) (48)
Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPARα. (2015) (48)
Inflammation is independent of steatosis in a murine model of steatohepatitis (2017) (48)
Role of human cytochrome P-450s in risk assessment and susceptibility to environmentally based disease. (1993) (48)
Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes. (1985) (48)
Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation. (2004) (48)
Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. (1991) (48)
Critical Role for Transcription Coactivator Peroxisome Proliferator-activated Receptor (PPAR)-binding Protein/TRAP220 in Liver Regeneration and PPARα Ligand-induced Liver Tumor Development* (2007) (48)
Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice (2006) (48)
CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid. (2013) (48)
Lipidomics Reveals a Link between CYP1B1 and SCD1 in Promoting Obesity (2014) (48)
Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice (2017) (48)
Metabolic activation of the potent carcinogen dibenzo[a,h]anthracene by cDNA-expressed human cytochromes P450. (1996) (47)
Aryl hydrocarbon receptor is required for p300-mediated induction of DNA synthesis by adenovirus E1A. (2000) (47)
The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. (2009) (47)
Epithelial cell PPAR[gamma] contributes to normal lung maturation. (2006) (47)
Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo. (2002) (47)
Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis. (2000) (47)
The CYP2D Subfamily (1996) (47)
Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer’s disease (2018) (47)
Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. (2004) (47)
Articles activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2 (1994) (47)
Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway. (2007) (47)
Chromosomal protein HMG-17. Complete human cDNA sequence and evidence for a multigene family. (1986) (46)
Peroxisome Proliferation-Activated Receptor (PPAR)γ Is Not Necessary for Synthetic PPARγ Agonist Inhibition of Inducible Nitric-Oxide Synthase and Nitric Oxide (2005) (46)
KLF4‐dependent, PPARγ‐induced expression of GPA33 in colon cancer cell lines (2009) (46)
Cloning and characterization of DNA complementary to rat liver UDP-glucuronosyltransferase mRNA. (1984) (46)
Orthogonal Comparison of GC-MS and 1H NMR Spectroscopy for Short Chain Fatty Acid Quantitation. (2017) (46)
HUMAN CYP2D6 AND MOUSE CYP2DS: ORGAN DISTRIBUTION IN A HUMANIZED MOUSE MODEL (2005) (46)
Role of hepatocyte nuclear factor 4α in control of blood coagulation factor gene expression (2006) (46)
4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. (2002) (46)
Role of Pregnane X Receptor in Control of All-Trans Retinoic Acid (ATRA) Metabolism and Its Potential Contribution to ATRA Resistance (2008) (46)
Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion (2004) (45)
T Cell-Specific Disruption of Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Gene Causes Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Thymic Involution 1 (2003) (45)
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2. (2003) (45)
LC-MS-based metabolomics in profiling of drug metabolism and bioactivation (2012) (45)
Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX. (2006) (45)
Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153-C/EBPbeta interaction. (2009) (45)
Xenobiotica the fate of foreign compounds in biological systems (2017) (45)
Oral benzo[a]pyrene‐induced cancer: Two distinct types in different target organs depend on the mouse Cyp1 genotype (2010) (44)
Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming (2018) (44)
Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity. (2003) (44)
PPAR alpha mediates peroxisome proliferator-induced transcriptional repression of nonperoxisomal gene expression in mouse. (1997) (43)
Use of inhibitory monoclonal antibodies to assess the contribution of cytochromes P450 to human drug metabolism. (2000) (43)
Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity (2013) (43)
Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma. (2016) (43)
Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization. (2016) (43)
Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). (2015) (43)
Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue. (2012) (43)
Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4α, and PGC-1αs⃞ Published, JLR Papers in Press, August 23, 2006. (2006) (43)
Coexpression of cytochrome P4502A6 and human NADPH-P450 oxidoreductase in the baculovirus system. (1997) (42)
Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha. (2009) (42)
Localization of CYP1A1 mRNA in human lung by in situ hybridization: Comparison with immunohistochemical findings (1998) (42)
Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity (2014) (42)
Analysis of the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) cistrome reveals novel co-regulatory role of ATF4 (2012) (42)
Role of CYP 2 E 1 in the Hepatotoxicity of Acetaminophen * (1996) (42)
Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. (2007) (42)
Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice (2010) (42)
Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis. (1999) (42)
Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation. (2006) (42)
P450 genes: evolution, regulation, and relationship to human cancer and pharmacogenetics. (1986) (42)
Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). (1993) (41)
Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression. (2017) (41)
Frequency of stromal lineage colony forming units in bone marrow of peroxisome proliferator-activated receptor-alpha-null mice. (2000) (41)
Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: implications for p53 ubiquitination. (2010) (41)
Lung-specific inactivation of CCAAT/enhancer binding protein α causes a pathological pattern characteristic of COPD (2009) (41)
Hepatic regeneration in peroxisome proliferator-activated receptor alpha-null mice after partial hepatectomy. (2002) (40)
Relationship between the CYP2D6 genotype and the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine (1997) (40)
Protective role of vascular smooth muscle cell PPARγ in angiotensin II-induced vascular disease. (2013) (40)
N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. (2014) (40)
Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse. (1998) (40)
Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice. (2000) (40)
Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity (2015) (40)
The Nuclear Receptor Peroxisome Proliferator-activated Receptor-β/δ (PPARβ/δ) Promotes Oncogene-induced Cellular Senescence through Repression of Endoplasmic Reticulum Stress* (2014) (40)
Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes. (2007) (40)
Pregnane X receptor‐ and CYP3A4‐humanized mouse models and their applications (2011) (40)
Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet. (2004) (40)
Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) inhibits chemically induced skin tumorigenesis. (2008) (40)
The gene CYP3 encoding P450pcn1 (nifedipine oxidase) is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22.1. (1988) (40)
Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance (2018) (40)
Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice. (2006) (39)
Fetal Mouse Cyp1b1 and Transplacental Carcinogenesis from Maternal Exposure to Dibenzo(a,l)pyrene (2008) (39)
Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge (2010) (39)
The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter. (2007) (39)
Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase. (2006) (39)
Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450, CYP2E1. (1991) (39)
Peroxisome Proliferator–Activated Receptor α Protects against Glomerulonephritis Induced by Long-Term Exposure to the Plasticizer Di-(2-Ethylhexyl)Phthalate (2007) (39)
The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene. (2009) (39)
Baculovirus-mediated expression and functional characterization of human NADPH-P450 oxidoreductase. (1992) (39)
PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice (2016) (39)
Metabolomics reveals aging-associated attenuation of noninvasive radiation biomarkers in mice: potential role of polyamine catabolism and incoherent DNA damage-repair. (2013) (38)
Identification and differentiation of hepatic stem cells during liver development. (2006) (38)
Inhibitory monoclonal antibodies to human cytochrome P450 enzymes: a new avenue for drug discovery. (1999) (38)
Interferon–microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis (2016) (38)
PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling (2013) (38)
Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene (1992) (38)
Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice. (2001) (38)
Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha. (2006) (38)
Metabolic profiling of praziquantel enantiomers. (2014) (38)
PPAR&agr; regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C (2017) (38)
Disruption of Endothelial Peroxisome Proliferator-Activated Receptor &ggr; Accelerates Diet-Induced Atherogenesis in LDL Receptor-Null Mice (2012) (38)
Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion. (1989) (38)
A species difference in the peroxisome proliferator-activated receptor α-dependent response to the developmental effects of perfluorooctanoic acid. (2013) (38)
Lack of correlation between phenotype and genotype for the polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin. (1997) (38)
Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6. (2006) (37)
Transcriptional induction of the cytochrome P4501A1 gene by a thiazolium compound, YH439. (1996) (37)
Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study (2016) (37)
The metabolism of 1-nitropyrene by human cytochromes P450. (1990) (37)
CYP3A4 and pregnane X receptor humanized mice (2007) (37)
Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice. (2012) (37)
Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models. (2019) (37)
Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice[S] (2018) (37)
Role of peroxisome proliferator-activated receptor-alpha in hepatobiliary injury induced by ammonium perfluorooctanoate in mouse liver. (2010) (37)
Myocardial Dysfunction and Male Mortality in Peroxisome Proliferator-Activated Receptor Alpha Knockout Mice Overexpressing Lipoprotein Lipase in Muscle (2003) (37)
Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway (2016) (36)
Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment (2019) (36)
Gemfibrozil and Fenofibrate, Food and Drug Administration-approved Lipid-lowering Drugs, Up-regulate Tripeptidyl-peptidase 1 in Brain Cells via Peroxisome Proliferator-activated Receptor α (2012) (36)
Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting (2020) (36)
Role of hepatocyte nuclear factor 4α in control of blood coagulation factor gene expression (2006) (36)
A Molecular Link between the Common Phenotypes of Type 1 Glycogen Storage Disease and HNF1α-null Mice* (2001) (36)
Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis. (2010) (36)
Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374. (1995) (36)
Over-production of IFN-gamma and IL-12 in AhR-null mice. (2005) (36)
Site-directed mutagenesis of cytochrome P450s CYP2A1 and CYP2A2: influence of the distal helix on the kinetics of testosterone hydroxylation. (1992) (36)
Recent update on the PPAR alpha-null mouse. (1997) (36)
Identification of novel polymorphisms in the 5' flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance. (2000) (36)
Functional characterization of peroxisome proliferator‐activated receptor‐β/δ expression in colon cancer (2011) (36)
Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. (2009) (36)
Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver (2012) (36)
The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A. (2013) (35)
In vitro translation of epoxide hydratase messenger RNA. (1980) (35)
Regulation of peroxisome proliferator‐activated receptor‐β/δ by the APC/β‐CATENIN pathway and nonsteroidal antiinflammatory drugs (2009) (35)
Diurnal Regulation of the Early Growth Response 1 (Egr-1) Protein Expression by Hepatocyte Nuclear Factor 4α (HNF4α) and Small Heterodimer Partner (SHP) Cross-talk in Liver Fibrosis* (2011) (35)
Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 alpha/beta. (2008) (35)
Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes. (2011) (35)
HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling. (2016) (35)
Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice. (2014) (35)
Clozapine pharmacokinetics and pharmacodynamics studied with CYP1A2-null mice (2000) (35)
Modulation of colon cancer by nutmeg. (2015) (35)
Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo. (2006) (35)
The accuracy of self‐reported drug ingestion histories in emergency department patients (2015) (35)
Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR. (2007) (35)
Humanized transgenic mouse models for drug metabolism and pharmacokinetic research. (2011) (34)
Sex steroid hormones regulate constitutive expression of Cyp2e1 in female mouse liver. (2013) (34)
Genetic polymorphism of CYP2D6 in the Japanese population. (1999) (34)
Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption. (2017) (34)
Characterization of the human cytochrome P450 isozymes responsible for styrene metabolism. (1993) (34)
Modulation of Lipid Metabolism by Celastrol. (2019) (34)
cDNA-directed expression of human cytochrome P450 CYP1A1 using baculovirus. Purification, dependency on NADPH-P450 oxidoreductase, and reconstitution of catalytic properties without purification. (1995) (34)
Reduced liver fibrosis in hypoxia-inducible factor-1 -deficient mice (2008) (34)
MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse (2013) (34)
Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models (2011) (34)
Targeted Disruption of the Peroxisome Proliferator—Activated Receptor α Gene, PPARα (1996) (33)
Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19. (2001) (33)
The Ability of C/EBP b but Not C/EBP a To Synergize with an Sp1 Protein Is Speciﬁed by the Leucine Zipper and Activation Domain (1997) (33)
Metabolomics reveals the metabolic map of procainamide in humans and mice. (2012) (33)
PPARalpha protects proximal tubular cells from acute fatty acid toxicity. (2007) (33)
Inhibitory and noninhibitory monoclonal antibodies to human cytochrome P450 2E1. (1996) (33)
Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha. (2009) (33)
Targeting Drug-Metabolizing Enzymes for Effective Chemoprevention and Chemotherapy (2010) (33)
Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver (2019) (33)
Di(2-ethylhexyl) phthalate induces a functional zinc deficiency during pregnancy and teratogenesis that is independent of peroxisome proliferator-activated receptor-alpha. (1997) (33)
A monoclonal antibody inhibitory to human P450 2D6: a paradigm for use in combinatorial determination of individual P450 role in specific drug tissue metabolism. (1997) (32)
Role of Farnesoid X Receptor in the Enhancement of Canalicular Bile Acid Output and Excretion of Unconjugated Bile Acids: A Mechanism for Protection against Cholic Acid-Induced Liver Toxicity (2005) (32)
Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice (2020) (32)
Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development (2018) (32)
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase. (1994) (32)
Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury (2017) (32)
Positive regulation of connexin32 transcription by hepatocyte nuclear factor-1alpha. (2002) (32)
Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy. (2014) (32)
Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice (2014) (31)
Cytochrome P450-null mice. (1999) (31)
PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein. (2013) (31)
The peroxisome proliferator-activated receptor alpha (PPARalpha): role in hepatocarcinogenesis. (2002) (31)
Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure (2017) (31)
cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3). (1989) (31)
Correlation between catalytic activity and protein content for the polymorphically expressed dihydropyrimidine dehydrogenase in human lymphocytes. (1995) (31)
6&bgr;-Hydroxytestosterone, a Cytochrome P450 1B1 Metabolite of Testosterone, Contributes to Angiotensin II–Induced Hypertension and Its Pathogenesis in Male Mice (2015) (31)
Therapeutic Efficacy of Wuzhi Tablet (Schisandra sphenanthera Extract) on Acetaminophen-Induced Hepatotoxicity through a Mechanism Distinct from N-Acetylcysteine (2015) (31)
Pretreatment with troglitazone decreases lethality during endotoxemia in mice (2002) (31)
Stable expression of human CYP2E1 in Chinese hamster cells: high sensitivity to N,N-dimethylnitrosamine in cytotoxicity testing. (1996) (31)
The CYP 2 D 6 Humanized Mouse : Effect of the Human CYP 2 D 6 Transgene and HNF 4 on the Disposition of Debrisoquine in the Mouse (2001) (31)
Antagonism of the actions of peroxisome proliferator-activated receptor-alpha by bile acids. (2001) (30)
Regulation of Mouse Hepatic α-Amino-β-Carboxymuconate-ϵ-Semialdehyde Decarboxylase, a Key Enzyme in the Tryptophan-Nicotinamide Adenine Dinucleotide Pathway, by Hepatocyte Nuclear Factor 4α and Peroxisome Proliferator-Activated Receptor α (2006) (30)
Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling (2019) (30)
Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor alpha (PPARalpha). (2000) (30)
PPARbeta/delta potentiates PPARgamma-stimulated adipocyte differentiation. (2004) (30)
Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. (2003) (30)
Tumour necrosis factor alpha (TNFalpha): role in suppression of apoptosis by the peroxisome proliferator nafenopin. (2000) (30)
Cytochrome P450 humanised mice (2004) (30)
PPARβ Regulates Liver Regeneration by Modulating Akt and E2f Signaling (2013) (30)
A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders[S] (2013) (30)
Maternal bile acid transporter deficiency promotes neonatal demise (2015) (30)
Role of the aryl hydrocarbon receptor and Cyp1b1 in the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2004) (29)
Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells. (2012) (29)
Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). (2006) (29)
Metabolism of methyl tert-butyl ether and other gasoline ethers in mouse liver microsomes lacking cytochrome P450 2E1. (1999) (29)
Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao). (1992) (29)
PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate. (2014) (29)
Effect of ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in human lung cancer cell lines. (2008) (29)
Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat (2015) (29)
Alterations in skin and stratified epithelia by constitutively activated PPARalpha. (2006) (29)
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines. (2007) (29)
Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology. (2013) (29)
Stimulation of cardiac cardiolipin biosynthesis by PPARα activation Published, JLR Papers in Press, November 1, 2003. DOI 10.1194/jlr.M300314-JLR200 (2004) (29)
1462V mutation in the human CYP1A1 gene: lack of correlation with either the Msp I 1.9 kb (M2) allele or CYP1A1 inducibility in a three-generation family of east Mediterranean descent. (1994) (29)
Distinct Functions of Vascular Endothelial and Smooth Muscle PPARγ in Regulation of Blood Pressure and Vascular Tone (2008) (29)
A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. (2011) (29)
Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver. (2001) (29)
Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα. (2011) (29)
Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling* (2019) (29)
Chlorogenic acid inhibits cholestatic liver injury induced by α‐naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation (2016) (28)
Anks4b, a Novel Target of HNF4α Protein, Interacts with GRP78 Protein and Regulates Endoplasmic Reticulum Stress-induced Apoptosis in Pancreatic β-Cells* (2012) (28)
Progressive Glomerulonephritis and Histiocytic Sarcoma Associated with Macrophage Functional Defects in CYP1B1-Deficient Mice (2004) (28)
Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. (2021) (28)
Regulation of drug transporters by the farnesoid X receptor in mice. (2004) (28)
Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. (2015) (28)
Modulation of Mouse Coagulation Gene Transcription following Acute In Vivo Delivery of Synthetic Small Interfering RNAs Targeting HNF4α and C/EBPα (2012) (28)
Molecular Regulation of Carcinogenesis: Friend and Foe. (2018) (28)
Sorting out the functional role(s) of peroxisome proliferator- activated receptor-β/δ (PPARβ/δ) in cell proliferation and cancer (2009) (28)
Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α (2009) (28)
Metabolic alterations in triptolide-induced acute hepatotoxicity. (2018) (28)
Cytochrome P450 in humans (1993) (28)
The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility (2002) (28)
PPARbeta/delta protects against experimental colitis through a ligand-independent mechanism. (2007) (28)
PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis. (2017) (28)
Metabolic differences in colon mucosal cells. (1993) (28)
Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha. (2006) (28)
Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans. (2000) (28)
Improved drug therapy: triangulating phenomics with genomics and metabolomics (2014) (28)
Pregnane X receptor-mediated induction of Cyp3a by black cohosh (2011) (28)
Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity (2006) (27)
Inhibition of JNK signalling mediates PPARα‐dependent protection against intrahepatic cholestasis by fenofibrate (2017) (27)
Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7. (2014) (27)
In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract (2014) (27)
Pregnane X receptor activation potentiates ritonavir hepatotoxicity. (2019) (27)
Cytochrome P-450 3A4 (nifedipine oxidase) is responsible for the C-oxidative metabolism of 1-nitropyrene in human liver microsomal samples. (1992) (27)
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice. (1999) (27)
PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells. (2010) (27)
Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7. (1990) (27)
Structure and expression of the rat CYP3A1 gene: isolation of the gene (P450/6betaB) and characterization of the recombinant protein. (1999) (27)
Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in keratinocytes. (2014) (27)
Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9. (1985) (27)
Modulation of erlotinib pharmacokinetics in mice by a novel cytochrome P450 3A4 inhibitor, BAS 100 (2008) (26)
Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). (2011) (26)
Transgenic models in xenobiotic metabolism and toxicology. (2002) (26)
HNFl α Activates the Rat UDP Glucuronosyltransferase UGT2B1 Gene Promoter (1997) (26)
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines. (2008) (26)
Cytochrome P450 Regulation by α-Tocopherol in Pxr-Null and PXR-Humanized Mice (2013) (26)
Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARα deterioration. (2011) (26)
Expression and regulation of human fetal-specific CYP3A7 in mice. (2012) (26)
Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor. (2009) (26)
Fenofibrate Metabolism in the Cynomolgus Monkey using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics (2009) (26)
The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides. (2018) (26)
Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E–Deficient Mice (2015) (26)
Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet. (2017) (26)
Cytochrome P450 1B1 Gene Disruption Minimizes Deoxycorticosterone Acetate-Salt–Induced Hypertension and Associated Cardiac Dysfunction and Renal Damage in Mice (2012) (26)
Stromal adipocyte PPARγ protects against breast tumorigenesis. (2012) (26)
Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes. (2000) (25)
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. (2008) (25)
An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver. (1999) (25)
A lipidomics investigation into the intervention of celastrol in experimental colitis. (2016) (25)
Effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on the cellular levels of epoxide hydratase, cytochrome P-450b, and NADPH-cytochrome c (P-450) oxidoreductase messenger ribonucleic acids. (1982) (25)
Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue. (2005) (25)
The study of xenobiotic-metabolizing enzymes and their role in toxicity in vivo using targeted gene disruption. (1998) (25)
Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) (2006) (25)
Control of Steroid 21-oic Acid Synthesis by Peroxisome Proliferator-activated Receptor α and Role of the Hypothalamic-Pituitary-Adrenal Axis* (2009) (25)
Deletion of the Aryl Hydrocarbon Receptor Enhances the Inflammatory Response to Leishmania major Infection (2011) (25)
Aryl hydrocarbon receptor‐mediated suppression of GH receptor and Janus kinase 2 expression in mice (2004) (25)
Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site. (2007) (25)
The role of the aryl hydrocarbon receptor in animal development, physiological homeostasis and toxicity of TCDD. (1996) (25)
The Evolution of Carcinogenesis. (2018) (25)
Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation. (2006) (25)
Role of PPARα and HNF4α in Stress-Mediated Alterations in Lipid Homeostasis (2013) (25)
Clofibrate-inducible rat hepatic P450s IVAl and IVA3 catalyze the a- and (a-1)-hydroxylation of fatty acids and the w-hydroxylation of prostaglandins El and F2a (1990) (25)
Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice. (2000) (25)
Pregnane X Receptor-Dependent Induction of the CYP3A4 Gene by o,p′-1,1,1,-Trichloro-2,2-Bis (p-Chlorophenyl)ethane (2007) (24)
Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice. (2020) (24)
Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha. (2006) (24)
Metabolic map of osthole and its effect on lipids (2018) (24)
Human cytochromes P450: evolution, catalytic activities and interindividual variations in expression. (1991) (24)
Vascular alpha-1D-adrenoceptors are overexpressed in aorta of the aryl hydrocarbon receptor null mouse: role of increased angiotensin II. (2008) (24)
Selenocysteine tRNA[Ser]Sec levels and selenium-dependent glutathione peroxidase activity in mouse embryonic stem cells heterozygous for a targeted mutation in the tRNA[Ser]Sec gene. (1997) (24)
Disruption of relative reward value by reversible disconnection of orbitofrontal and rhinal cortex using DREADDs in rhesus monkeys (2015) (24)
Role of CYP1A2 and CYP2E1 in the pentoxifylline ciprofloxacin drug interaction. (2004) (24)
Cyp 2 c 70 is responsible for the species difference in bile acid metabolism between mice and humans (2016) (24)
2,3-epoxy-4-hydroxynonanal, a potential lipid peroxidation product for etheno adduct formation, is not a substrate of human epoxide hydrolase. (1998) (24)
Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. (2013) (24)
Loss of von Hippel-Lindau Protein (VHL) Increases Systemic Cholesterol Levels through Targeting Hypoxia-Inducible Factor 2α and Regulation of Bile Acid Homeostasis (2014) (24)
Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity (2015) (23)
Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport. (2019) (23)
Evidence for peroxisome proliferator-activated receptor (PPAR)alpha-independent peroxisome proliferation: effects of PPARgamma/delta-specific agonists in PPARalpha-null mice. (2000) (23)
Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver. (1998) (23)
Gemfibrozil, a Lipid-lowering Drug, Increases Myelin Genes in Human Oligodendrocytes via Peroxisome Proliferator-activated Receptor-β* (2012) (23)
PPARβ/δ activation of CD300a controls intestinal immunity (2014) (23)
Analysis of human cytochrome P450 catalytic activities and expression. (1992) (23)
Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes (2018) (23)
TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury[S] (2012) (23)
2-Methoxyestradiol Reduces Angiotensin II–Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice (2017) (23)
Role of Hypoxia-Inducible Factor 1&agr; in T Cells as a Negative Regulator in Development of Vascular Remodeling (2010) (23)
Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver* (2015) (23)
Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum (2013) (23)
Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy (2015) (22)
Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. (2013) (22)
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line. (2010) (22)
Octachlorostyrene induces cytochrome P450, UDP-glucuronosyltransferase, and sulfotransferase via the aryl hydrocarbon receptor and constitutive androstane receptor. (2009) (22)
Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo. (2010) (22)
Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice. (2008) (22)
P450 genes and evolutionary genetics. (1987) (22)
Association of V227A PPAR&agr; polymorphism with altered serum biochemistry and alcohol drinking in Japanese men (2006) (22)
Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice (2011) (22)
Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice (2018) (22)
Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis (2018) (22)
Global Metabolomics Reveals Urinary Biomarkers of Breast Cancer in a MCF-7 Xenograft Mouse Model (2013) (22)
C/EBPalpha is a regulator of the UDP glucuronosyltransferase UGT2B1 gene. (1998) (22)
Cross-reactivity of thirteen monoclonal antibodies with ten vaccinia cDNA expressed rat, mouse and human cytochrome P450s. (1993) (22)
The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. (2004) (22)
Styrene Trimer May Increase Thyroid Hormone Levels via Down-Regulation of the Aryl Hydrocarbon Receptor (AhR) Target Gene UDP-Glucuronosyltransferase (2008) (22)
Activation of aryl hydrocarbon receptor regulates the LPS/IFN&ggr;‐induced inflammatory response by inducing ubiquitin‐proteosomal and lysosomal degradation of RelA/p65 (2018) (21)
Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues. (1994) (21)
Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression. (2016) (21)
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity (2019) (21)
Chemoprevention of Chemically Induced Skin Tumorigenesis by Ligand Activation of Peroxisome Proliferator–Activated Receptor-β/δ and Inhibition of Cyclooxygenase 2 (2010) (21)
Getting fat: two new players in molecular adipogenesis. (2005) (21)
Specific cytosine demethylations within the first exons of the rat CYP2D3 and CYP2D5 genes are associated with activation of hepatic gene expression during development. (1990) (21)
Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha (2017) (21)
Role of cytochrome P-450 2E1 in methacrylonitrile metabolism and disposition. (1999) (21)
The Med1 Subunit of the Mediator Complex Induces Liver Cell Proliferation and Is Phosphorylated by AMP Kinase* (2013) (21)
Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for Cancer Chemoprevention (2015) (21)
Comparative Impacts of Knockouts of Two Antioxidant Enzymes on Acetaminophen-Induced Hepatotoxicity in Mice (2009) (21)
Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation. (2016) (21)
Metabolism of polycyclic aza-aromatic carcinogens catalyzed by four expressed human cytochromes P450. (1995) (21)
Cytochrome P450 2A1, 2E1, and 2C9 cDNA-expression by insect cells and partial purification using hydrophobic chromatography. (1995) (21)
Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. (2004) (21)
Inflammatory modulation of PPARγ expression and activity (2006) (21)
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice (2018) (21)
Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption (2009) (20)
Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice. (2001) (20)
Celastrol ameliorates acute liver injury through modulation of PPARα. (2020) (20)
Peroxisome proliferator‐activated receptor‐β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53‐ and SOX2‐mediated cell differentiation (2017) (20)
Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease (2013) (20)
The rat P450 IID subfamily: Complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site (1990) (20)
Role of peroxisome-proliferator-activated receptor β / δ (PPAR β / δ ) in gastrointestinal tract function and disease (2009) (20)
Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha. (2000) (20)
Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile? (2003) (20)
Protection against SR 4233 (Tirapazamine) aerobic cytotoxicity by the metal chelators desferrioxamine and tiron. (1994) (20)
A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis (2020) (20)
The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4. (2016) (20)
Ligand Activation of Peroxisome Proliferator–Activated Receptor b / d (PPAR b / d ) Attenuates Carbon Tetrachloride Hepatotoxicity by Downregulating Proinﬂammatory Gene Expression (2008) (20)
Structure-Activity Relationships of the Main Bioactive Constituents of Euodia rutaecarpa on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis (2018) (19)
Polyamine metabolism links gut microbiota and testicular dysfunction (2021) (19)
Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota. (2016) (19)
Activation of promutagens by human cDNA-expressed cytochrome P450s. (1990) (19)
Application of mass spectrometry-based metabolomics in identification of early noninvasive biomarkers of alcohol-induced liver disease using mouse model. (2015) (19)
Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2 (2016) (19)
CCAAT/Enhancer-binding Protein δ (C/EBPδ) Maintains Amelogenin Expression in the Absence of C/EBPα in Vivo* (2007) (19)
Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In Vitro (2018) (19)
Cigarette Smoke Toxins-Induced Mitochondrial Dysfunction and Pancreatitis Involves Aryl Hydrocarbon Receptor Mediated Cyp1 Gene Expression: Protective Effects of Resveratrol (2018) (18)
Keratin 23 Is a Peroxisome Proliferator‐Activated Receptor Alpha–Dependent, MYC‐Amplified Oncogene That Promotes Hepatocyte Proliferation (2019) (18)
Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse (2000) (18)
T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD. (2017) (18)
Selective suppression of the catalytic activity of cDNA-expressed cytochrome P4502B1 toward polycyclic hydrocarbons in the microsomal membrane: modification of this effect by specific amino acid substitutions. (1992) (18)
Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor (2015) (18)
Stereoselective Metabolism of Bufuralol Racemate and Enantiomers in Human Liver Microsomes (2002) (18)
Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7. (1990) (18)
CYP2E1 (2007) (18)
Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor. (2008) (18)
Sequential translocation of two phenobarbital-induced polysomal messenger ribonucleic acids from the nuclear envelope to the endoplasmic reticulum. (1981) (18)
New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases. (2016) (17)
Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis (2021) (17)
In vivo stabilization of nuclear retinoid X receptor α in the presence of peroxisome proliferator‐activated receptor α (2003) (17)
Vascular smooth muscle cell peroxisome proliferator-activated receptor &ggr; protects against endothelin-1-induced oxidative stress and inflammation (2017) (17)
The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria (2019) (17)
Differential inducibility of nuclear envelope epoxide hydratase by trans-stilbene oxide and phenobarbital. (1982) (17)
Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation. (2004) (17)
Editor’s Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway (2017) (17)
Metabolomics: an essential tool to understand the function of peroxisome proliferator-activated receptor alpha. (2013) (17)
Genetic toxicology using human cell lines expressing human P-450. (1993) (17)
Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling (2018) (17)
Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells. (2018) (17)
PPARα Mediates the Hepatoprotective Effects of Nutmeg. (2018) (17)
Analysis of N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine/N1‐acetyl‐5‐methoxy‐kynuramine formation from melatonin in mice (2010) (16)
Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice. (2004) (16)
Human Placental Lactogen Induces CYP2E1 Expression via PI 3-Kinase Pathway in Female Human Hepatocytes (2014) (16)
CYP 2 E 1 is not involved in early alcohol-induced liver injury (1999) (16)
Metabolomics Reveals That Tumor Xenografts Induce Liver Dysfunction* (2013) (16)
Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles. (2003) (16)
Alternative splicing in the human cytochrome P450IIB6 gene: use of a cryptic exon within intron 3 and splice acceptor site within exon 4 (1990) (16)
Synergistic effects of genetic beta cell dysfunction and maternal glucose intolerance on offspring metabolic phenotype in mice (2011) (16)
Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide. (2005) (16)
Identification, bioactivity evaluation and pharmacokinetics of multiple components in rat serum after oral administration of Xian-Ling-Gu-Bao capsule by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. (2017) (16)
Control of constitutively-expressed developmentally-activated rat hepatic cytochrome P450 genes. (1992) (16)
Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation (2020) (16)
Inhibition of UDP‐Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis (2015) (16)
Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression. (2006) (16)
Medical implications of HGP's sequence of chromosome 22 (2000) (16)
Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver. (2013) (16)
Cytochrome P 4501 B 1 Mediates Induction of Bone Marrow Cytotoxicity and Preleukemia Cells in Mice Treated with 7 , 12-Dimethylbenz [ a ] anthracene 1 (2000) (16)
Peroxisome Proliferator-Activated Receptor β/δ Cross Talks with E2F and Attenuates Mitosis in HRAS-Expressing Cells (2012) (16)
Role of Metabolic Activation in Elemicin-induced Cellular Toxicity. (2019) (15)
THE CYP 2 E 1-HUMANIZED TRANSGENIC MOUSE : ROLE OF CYP 2 E 1 IN ACETAMINOPHEN HEPATOTOXICITY (2004) (15)
PPARα-Dependent Induction of Liver Microsomal Esterification of Estradiol and Testosterone by a Prototypical Peroxisome Proliferator. (2001) (15)
Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation (2020) (15)
Activation of Intestinal Human Pregnane X Receptor Protects against Azoxymethane/Dextran Sulfate Sodium–Induced Colon Cancer (2014) (15)
Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3 (2021) (15)
Peroxisome proliferator-activated receptor alpha regulates B lymphocyte development via an indirect pathway in mice. (2004) (15)
Metabolic profiling of corylin in vivo and in vitro (2018) (15)
Parkin is Transcriptionally Regulated by the Aryl Hydrocarbon Receptor: Impact on α-Synuclein Protein Levels. (2019) (15)
PPAR a Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver 1–3 (2011) (15)
GC-MS metabolomics on PPARα-dependent exacerbation of colitis. (2015) (15)
Ligand activation of peroxisome proliferator-activated receptor b / d (PPAR b / d ) inhibits chemically induced skin tumorigenesis (2008) (15)
Developmental regulation of hepatic testosterone hydroxylases: simultaneous activation and repression of constitutively expressed cytochromes P450 in senescent rats. (1990) (15)
MicroRNA-1291-5p Sensitizes Pancreatic Carcinoma Cells to Arginine Deprivation and Chemotherapy through the Regulation of Arginolysis and Glycolysis (2020) (15)
Purification, characterization, and kinetics of porcine recombinant dihydropyrimidine dehydrogenase. (1997) (15)
Sequence requirements for cytochromes P450IIA1 and P450IIA2 catalytic activity: evidence for both specific and non-specific substrate binding interactions through use of chimeric cDNAs and cDNA expression. (1990) (15)
6&bgr;-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone–Metabolite, Mediates Angiotensin II–Induced Renal Dysfunction in Male Mice (2016) (15)
Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA‐V227A Polymorphism (2007) (15)
Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism (2015) (15)
Editor’s Highlight: PPAR&bgr;/&dgr; and PPAR&ggr; Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis (2017) (15)
Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage (2016) (15)
The Protective Roles of PPARα Activation in Triptolide-induced Liver Injury. (2019) (15)
Effect of prenatal peroxisome proliferator-activated receptor alpha (PPARalpha) agonism on postnatal development. (2010) (15)
Complete sequence of the rat CYP2A3 gene specifically transcribed in lung. (1990) (15)
YAP-TEAD mediates peroxisome proliferator-activated receptor α-induced hepatomegaly and liver regeneration in mice. (2021) (15)
Inhibitory monoclonal antibodies to human cytochrome P450 2D6. (1997) (14)
Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice (2017) (14)
Pregnane X Receptor–Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity (2015) (14)
Cloning and characterization of the rat NADPH-cytochrome P-450 oxidoreductase gene. (1983) (14)
Metabolic mapping of A3 adenosine receptor agonist MRS5980. (2015) (14)
Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice (2012) (14)
Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro. (2016) (14)
Metabolism of Benzo[a]pyrene by Seven cDNA Expressed Human Cytochromes P450 (1994) (14)
Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα. (2020) (14)
Targeted Metabolomics Reveals a Protective Role for Basal PPARα in Cholestasis Induced by α-Naphthylisothiocyanate. (2018) (14)
Identification of 2‐Piperidone as a Biomarker of CYP2E1 Activity through Metabolomic Phenotyping (2011) (14)
Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence (2020) (14)
Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice. (2016) (14)
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities (2021) (14)
Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling* (2015) (14)
Beta-Cell ARNT Is Required for Normal Glucose Tolerance in Murine Pregnancy (2013) (14)
Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy* (2016) (14)
A natural propenoic acid derivative activates peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). (2010) (14)
Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling. (2019) (14)
Sparteine metabolism capacity in human liver: structural variants of human P450IID6 as assessed by immunochemistry. (1990) (14)
Intestinal MYC modulates obesity-related metabolic dysfunction (2021) (14)
Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan. (2016) (13)
β Cell Hypoxia-Inducible Factor-1 α Is Required for the Prevention of Type 1 Diabetes (2019) (13)
Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms (2017) (13)
Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome (2019) (13)
Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosis. (2019) (13)
In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes (2017) (13)
Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis (2018) (13)
Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases. (2015) (13)
DRUG METABOLISM (2004) (13)
Molecular biology of human xenobiotic-metabolizing cytochromes P450: role of vaccinia virus cDNA expression in evaluating catalytic function. (1993) (13)
Myelocytomatosis‐Protein Arginine N‐Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma (2021) (13)
Peroxisome proliferator-activated receptor alpha protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl)phthalate. (2007) (13)
Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice (2020) (13)
Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation (2018) (13)
Hepatocyte nuclear factors 1α and 4α control expression of proline oxidase in adult liver (2004) (13)
Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides. (2018) (13)
Structure and regulation of P-450s in the rat P450IIA gene subfamily. (1989) (13)
3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic Ratio (2006) (13)
Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice (2014) (13)
Chromosomal Protein HMG- 17 (1986) (13)
Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity (2017) (13)
Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver (2021) (13)
In vitro systems for prediction of rates of drug clearance and drug interactions. (1992) (13)
Withaferin A Improves Nonalcoholic Steatohepatitis in Mice (2019) (13)
Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice. (2019) (13)
Applications of Genetically Manipulated Mice in Pharmacogenetics and Pharmacogenomics (2000) (13)
Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). (2006) (13)
TCDD induces UbcH7 expression and synphilin‐1 protein degradation in the mouse ventral midbrain (2017) (13)
The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors (2019) (12)
Oxidative metabolism of bunitrolol by complementary DNA-expressed human cytochrome P450 isozymes in a human hepatoma cell line (Hep G2) using recombinant vaccinia virus. (1995) (12)
The pathophysiological function of non-gastrointestinal farnesoid X receptor. (2021) (12)
HUMAN CYP 2 D 6 AND MOUSE CYP 2 DS : ORGAN DISTRIBUTION IN A HUMANIZED MOUSE MODEL (2005) (12)
Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARαPAC mice due to dysregulated bile acid synthesis (2015) (12)
Nuclear receptors and non-alcoholic fatty liver disease: An update (2020) (12)
Gut bacteria alleviate smoking-related NASH by degrading gut nicotine (2022) (12)
Regulation profile of phosphatidylcholines (PCs) and lysophosphatidylcholines (LPCs) components towards UDP-glucuronosyltransferases (UGTs) isoforms (2015) (12)
Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes. (2017) (12)
Cell-free translation of mouse liver mRNA coding for two forms of UDP glucuronosyltransferase. (1984) (12)
Acetaminophen-Induced Toxicity (2009) (12)
A multiparametric organ toxicity predictor for drug discovery (2020) (12)
Localization of CYP2F1 by multipoint linkage analysis and pulsed-field gel electrophoresis. (1991) (12)
Identification of Functions of Peroxisome Proliferator- Activated Receptor in Proximal Tubules (2002) (12)
Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450. (1994) (12)
Mouse lung CYP 1 A 1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo [ 4 , 5b ] pyridine ( PhIP ) (2007) (12)
Human P3(450): cDNA and complete amino acid sequence. (1986) (12)
Analysis of cis-acting regions upstream of the rat Na+/K(+)-ATPase alpha 1 subunit gene by in vivo footprinting. (1995) (12)
Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma (2019) (12)
Overview of experimental approaches for study of drug metabolism and drug-drug interactions. (1997) (11)
Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites (2020) (11)
2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances CCl4-induced hepatotoxicity in an aryl hydrocarbon receptor-dependent manner (2013) (11)
Role of β‐catenin in the adult liver (2006) (11)
Metabolomics Reveals a Role for the Chromatin-Binding Protein HMGN5 in Glutathione Metabolism (2014) (11)
Inflammatory modulation of PPAR gamma expression and activity. (2006) (11)
Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer. (2016) (11)
Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L. (2017) (11)
Differential Effects of CYP 2 E 1 Status on the Metabolic Activation of the Colon Carcinogens Azoxymethane and Methylazoxymethanol 1 (2001) (11)
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis. (2017) (11)
Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1. (2020) (11)
Role of beta-catenin in the adult liver. (2006) (11)
cDNA-directed expression of rat P450s IIA1 and IIA2. Catalytic activities toward steroids and xenobiotics and comparison with the enzymes purified from liver. (1990) (11)
Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice (2020) (11)
Hepatic peroxisome proliferator‐activated receptor alpha mediates the major metabolic effects of Wy‐14643 (2018) (11)
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms (2015) (11)
A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice. (2019) (11)
Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. (2020) (11)
Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice (2018) (11)
Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells (2016) (11)
Myotoxicity of gemfibrozil in cynomolgus monkey model and its relationship to pharmacokinetic properties. (2009) (11)
Potential role of the vitamin D receptor in control of cholesterol levels. (2014) (11)
A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice. (2020) (11)
Disruption of the cytochrome P-450 1B1 gene exacerbates renal dysfunction and damage associated with angiotensin II-induced hypertension in female mice. (2015) (11)
Targeting xenobiotic nuclear receptors PXR and CAR to prevent cobicistat hepatotoxicity. (2021) (11)
Animal models for human risk assessment: the peroxisome proliferator-activated receptor alpha-humanized mouse. (2007) (11)
6β-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice (2020) (10)
PPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis (2015) (10)
Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis (2022) (10)
A transgenic mouse expressing human CYP1A2 in the pancreas. (2000) (10)
ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output. (2007) (10)
Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu‐gu‐zhi) and its potential inhibition against human cytochrome P450s and UDP‐glucuronosyltransferases (2020) (10)
Relative importance of maternal and embryonic microsomal epoxide hydrolase in 7,12-dimethylbenz[a]anthracene-induced developmental toxicity. (2002) (10)
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities (2022) (10)
Effect of ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in human lung cancer cell lines (2008) (10)
Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice. (2016) (10)
In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice. (2019) (10)
In vitrometabolic mapping of neobavaisoflavone in human cytochromes P450 and UDP‐glucuronosyltransferase enzymes by ultra high‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry (2018) (10)
Cloning of epoxide hydratase complementary DNA. (1981) (10)
Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate. (2005) (9)
A systemic workflow for profiling metabolome and lipidome in tissue. (2019) (9)
T Cell-Specific Disruption of Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Gene Causes Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Thymic Involution (2003) (9)
Methylation differences in the murine P1450 and P3450 genes in wild-type and mutant hepatoma cell culture. (1986) (9)
The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells. (2018) (9)
Aryl Hydrocarbon Receptor Is Required for p 300-Mediated Induction of DNA Synthesis by Adenovirus E 1 A (2000) (9)
Microarray Analysis Using Amplified mRNA from Laser Capture Microdissection of Microscopic Hepatocellular Precancerous Lesions and Frozen Hepatocellular Carcinomas Reveals Unique and Consistent Gene Expression Profiles (2003) (9)
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild‐type, Cyp1b1 knockout, and CYP1B1 humanized mice (2017) (9)
Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ (2018) (9)
Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo (2015) (9)
Human cytochrome P450: possible roles of drug-metabolizing enzymes and polymorphic drug oxidation in addiction. (1991) (9)
PPARα‐independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling (2018) (9)
PPARα is down-regulated following liver transplantation in mice. (2012) (9)
Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling (2021) (9)
Fat-specific protein 27 is a novel target gene of liver X receptor α (2018) (9)
Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature. (2021) (8)
Utilization of ketone bodies by chick brain and spinal cord during embryonic and postnatal development (1993) (8)
1 Adipocyte-specific Gene Expression and Adipogenic Steatosis in the Mouse Liver due to PPAR γ 1 Overexpression * (2002) (8)
Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. (2004) (8)
Hepatic metabolic adaptation in a murine model of glutathione deficiency. (2019) (8)
12 alpha-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2. (1992) (8)
Propranolol is a mechanism‐based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6‐transgenic mice: Effects on activity and drug responses (2020) (8)
Cytochrome P450 Evolution and Nomenclature (1993) (8)
Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature (2021) (8)
Improved detection and precise relative quantification of the urinary cancer metabolite biomarkers - Creatine riboside, creatinine riboside, creatine and creatinine by UPLC-ESI-MS/MS: Application to the NCI-Maryland cohort population controls and lung cancer cases. (2020) (8)
Role of the Pregnane X Receptor in Binge Ethanol-Induced Steatosis and Hepatotoxicity (2018) (8)
PPARalpha-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator. (2001) (8)
Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice (2020) (8)
Efflux excretion of bisdemethoxycurcumin‐O‐glucuronide in UGT1A1‐overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance‐associated proteins 1 (MRP1) as the glucuronide transporters (2018) (8)
FXR-Deoxycholic Acid-TNFα Axis Modulates Acetaminophen-Induced Hepatotoxicity. (2021) (8)
Role of peroxisome proliferator-activated receptor- α in fasting-mediated oxidative stress (2009) (7)
McLeod et al. reply: Pyrimidine metabolism has a role in normal physiology as well as in regulating drug effects (1996) (7)
Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone. (2000) (7)
Transcriptional and posttranscriptional regulation of CYP2E1, an N-nitrosodimethylamine demethylase. (1990) (7)
Peroxisome Proliferator‐Activated Receptor α Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil (2017) (7)
Cloning of DNA complementary to ornithine aminotransferase mRNA. (1982) (7)
St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling (2015) (7)
Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis (2019) (7)
Two pathways of apoptosis are simultaneously induced in the embryonal brains of neural cell-specific HIF-1α-deficient mice (2006) (7)
Structure and regulation of the ethanol-inducible cytochrome P450j. (1988) (7)
Human CYP 2 C 9 and CYP 2 A 6 Mediate Formation of the Hepatotoxin 4-Ene-Valproic Acid 1 (1997) (7)
High density lipoprotein turnover is dependent on peroxisome proliferator-activated receptor α in mice. (2010) (7)
An inhibitory monoclonal antibody to human cytochrome P450 that specifically binds and inhibits P4502C9II, an allelic variant of P4502C9 having a single amino acid change Arg144 Cys (2000) (7)
Species differences between mouse and human PPARα in modulating the hepatocarcinogenic effects of perinatal exposure to a high-affinity human PPARα agonist in mice. (2021) (7)
Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver[S] (2014) (7)
Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights (2021) (7)
Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer (2022) (7)
Cardiomyocyte peroxisome proliferator-activated receptor α is essential for energy metabolism and extracellular matrix homeostasis during pressure overload-induced cardiac remodeling (2021) (7)
Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice. (2020) (7)
Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo. (2014) (7)
Mutations at codon 974 of the DPYD gene are a rare event. (1997) (7)
Liver PPAR γγγγ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass. (2003) (6)
Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung. (2017) (6)
Targeting Estrogen Receptor-β for the Prevention of Nonmelanoma Skin Cancer (2014) (6)
Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia. (2006) (6)
Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice (2013) (6)
Non-targeted metabolomics reveals diagnostic biomarker in the tongue coating of patients with chronic gastritis. (2019) (6)
Non-invasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer (2014) (6)
Insulin Represses Fasting-Induced Expression of Hepatic Fat-Specific Protein 27. (2017) (6)
Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin‐O‐glucuronide in HeLa1A1 cells (2020) (6)
Peroxisome proliferator‐activated receptor‐β/δ modulates mast cell phenotype (2017) (6)
Biphasic regulation of intracellular calcium by gemfibrozil contributes to inhibiting L6 myoblast differentiation: implications for clinical myotoxicity. (2011) (6)
Comparative effect of fasting on acetoacetate and D-3-hydroxybutyrate metabolism in the newborn chick. (1992) (6)
The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inﬂammation, ﬁbrosis, and proteinuria (2009) (6)
Metabolism and disposition of corylifol A from Psoralea corylifolia: metabolite mapping, isozyme contribution, species differences and identification of efflux transporters for corylifol A-O-glucuronide in HeLa1A1 cells (2020) (6)
HNF1 alpha activates the rat UDP glucuronosyltransferase UGT2B1 gene promoter. (1997) (6)
Sequence of the 5' end of the developmentally regulated rat P450 PB1 (P450IIC6) gene (1988) (6)
Mutagen activation by cDNA-expressed P(1)450, P(3)450, and P450a. (1989) (6)
An example of P-450 catalytic activities not correlated with corresponding P-450 mRNA concentrations. (1986) (6)
[Phosphotyrosine phosphatase SHP-1, somatostatin and prostate cancer]. (2004) (6)
Monoclonal antibodies to rat liver microsomal cytochrome b5. (1992) (6)
Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence (2020) (6)
Retrieval of promiscuous natural compounds using multiple targets docking strategy: A case study on kinase polypharmacology (2017) (6)
Regulatory mechanisms mediated by peroxisome proliferator‐activated receptor‐β/δ in skin cancer (2019) (5)
Hepatic PPARα mediates the major metabolic effects of Wy-14643 (2017) (5)
Abstract 492: Hepatic oxidative stress activates the Gadd45b gene via degradation of the transcriptional repressor STAT3 (2014) (5)
Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung. (2012) (5)
PPAR α Activation During Pregnancy Severely Impairs Mammary Lobuloalveolar Development in Mice (2008) (5)
Diminished hepatocarcinogenesis by a potent, high affinity human PPARα agonist in PPARA-humanized mice. (2021) (5)
Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene (2016) (5)
Retraction: Disruption of the NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Gene in Mice Causes Myelogenous Hyperplasia. (2018) (5)
HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1. (2020) (5)
Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6β-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation (2020) (5)
Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications (2020) (5)
Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1 (2019) (5)
Hepatocyte nuclear factor 4α regulates the expression of intestinal epithelial Na+/H+ exchanger isoform 3. (2018) (5)
Role of nuclear bile acid receptor, FXR, in determining ATP-binding casette (ABC) transporter expression and cholestatic liver injury in common bile duct-ligated mice (2003) (5)
Ligand activation of peroxisome proliferator-activated receptor-β/ δ (PPAR β/δ) inhibits cell growth in a mouse mammary gland cancer cell line (2010) (5)
Epigenome-Wide Analysis of DNA Methylation in Parkinson’s Disease Cortex (2022) (5)
Feedback repression of PPARα signaling by Let-7 microRNA (2021) (5)
Changes in ketone body utilization by chick liver, duodenal mucosa and kidney during embryonic and postnatal development. (1993) (5)
Models and Technologies Activation of Peroxisome Proliferator-Activated Receptor-b / d ( PPAR-b / d ) Inhibits Human Breast Cancer Cell Line Tumorigenicity (2014) (5)
Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron‐induced hepatotoxicity (2021) (5)
YAP‐TEAD mediates PPAR α–induced hepatomegaly and liver regeneration in mice (2021) (5)
Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity (2022) (5)
Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice (2022) (5)
Critical role of peroxisome proliferator-activated receptor a in promoting platelet hyperreactivity and thrombosis under hyperlipidemia (2021) (5)
Aryl hydrocarbon receptor-mediated suppression of expression of the low-molecular-weight prekininogen gene in mice. (2001) (4)
ERR agonism reverses mitochondrial dysfunction and inflammation in the aging kidney (2019) (4)
PPARα mediates night neon light-induced weight gain: role of lipid homeostasis (2020) (4)
Metabolic activation of elemicin leads to the inhibition of stearoyl-CoA desaturase 1. (2019) (4)
Hepatic Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) regulates metabolism in mice (2017) (4)
Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC-MS/MS and its pharmacokinetic study. (2018) (4)
A natural propenoic acid derivative activates peroxisome proliferator-activated receptor- β / δ (PPAR β / δ ) (2010) (4)
PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice (2016) (4)
Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL (2021) (4)
KLF 4-dependent , PPAR γ-induced expression of GPA 33 in colon cancer cell lines (2009) (4)
St. John’s Wort alleviates dextran sodium sulfate‐induced colitis through pregnane X receptor‐dependent NFκB antagonism (2021) (4)
Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89]. (2018) (4)
Role of nuclear bile salt receptors Fxr and Pxr in mediating adaptive hepatobiliary transporter response to cholic acid (CA) in mouse liver (2003) (4)
The pressing need for combined genotype-phenotype analysis in clinical practice. (2002) (4)
Cholestasis induces reversible accumulation of periplakin in mouse liver (2013) (4)
Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis (2022) (4)
Mapping of cytochrome P-450 distribution and function with monoclonal antibodies and cDNA expression. (1990) (4)
Regulation of CREB and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α (2013) (4)
Cytochrome P 450 1 B 1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E – Deficient Mice (4)
Targeted disruption of specific cytochromes P450 and xenobiotic receptor genes. (1996) (4)
PPARα activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver. (2016) (4)
Peroxisome proliferator activated receptor c in colonic epithelial cells protects against experimental inflammatory bowel disease (2006) (4)
HNF4A modulates glucocorticoid action in the liver (2022) (3)
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity (2021) (3)
Oleuropein-induced acceleration of CYP-catalyzed drug metabolism: central role for nuclear receptor PPAR α. (2021) (3)
Withaferin A improves non-alcoholic steatohepatitis in mice (2019) (3)
A Western diet-induced mouse model reveals a possible mechanism by which metformin decreases obesity (2017) (3)
Adrenoceptor‐related decrease in serum triglycerides is independent of PPARα activation (2019) (3)
The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice. (2021) (3)
The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase. (2006) (3)
Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophy (2022) (3)
Nuclear Receptor PPARα Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKβ-Deficient Mice (2017) (3)
Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire‐Injured Carotid Artery of Male Mice (2018) (3)
Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation. (2001) (3)
Postprandial plasma lipidomics reveal specific alteration of hepatic-derived diacylglycerols in non-alcoholic fatty liver disease. (2022) (3)
Aryl hydrocarbon receptor deficient mice (Ahr-/-) exhibit an accumulation of liver retinylpalmitate (1997) (3)
The role of cytochrome P450 in the elimination of bilirubin in congenital jaundice (Crigler-Najjar Syndrome Type I) (1992) (3)
Thymic involution produced by diesel exhaust particles and their constituents in mice (2006) (3)
Testosterone Metabolite 6β‐Hydroxytestosterone Contributes to Angiotensin II‐Induced Abdominal Aortic Aneurysms in Apoe –/– Male Mice (2021) (3)
Bone Marrow Stromal Cell Cytochrome P 4501 B 1 Is Required for Pre-B Cell Apoptosis Induced by 7 , 12-Dimethylbenz [ a ] anthracene 1 (1999) (3)
Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress (2019) (3)
Human Cells as an Expression System for Cytochromes P450 (1994) (3)
YAP‐TEAD mediates peroxisome proliferator‐activated receptor α‐ induced hepatomegaly and liver regeneration in mice (2021) (3)
Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus (2021) (2)
Metabolomics Identifies Novel Hnf1α-Dependent Physiological Pathwaysin Vivo (2010) (2)
2-Methoxyestradiol Ameliorates Angiotensin II–Induced Hypertension by Inhibiting Cytosolic Phospholipase A2α Activity in Female Mice (2021) (2)
Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity (2022) (2)
Inhibitory monoclonal antibodies and cDNA expression for the characterization of cytochrome P450 function (1990) (2)
Urinary Metabolomics Analyses Identify Novel Markers of Malignant Adrenocortical Neoplasms (2015) (2)
The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β‐catenin activation (2019) (2)
MicroRNA-1291 effects on pancreatic cancer (PC) cells sensitivity to arginine deprivation and chemotherapy through modulation of ASS1 and GLUT1. (2018) (2)
Novel Strategy for Mining and Identification of Acylcarnitines Using Data-Independent-Acquisition-Based Retention Time Prediction Modeling and Pseudo-Characteristic Fragmentation Ion Matching. (2021) (2)
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal. (2022) (2)
Pharmacogenetics Polymorphisms in Xenobiotic Metabolism (1999) (2)
PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL REGULATION OF CYTOCHROME P 450 (1998) (2)
Discovery and characterization of naturally occurring potent inhibitors of catechol-O-methyltransferase from herbal medicines (2021) (2)
Evidence for the transient expression of P-450 during the neonatal period in rat. (1994) (2)
Metabolic profiling of the novel HIF 2 α inhibitor PT 2385 in vivo and in vitro (2018) (2)
Reply to Bile acids in Non-Alcoholic Steato-Hepatitis: inserting nuclear receptors into the circle. (2012) (2)
Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stress. (2006) (2)
Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulation. (2011) (2)
In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha. (2003) (2)
Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis (2019) (2)
Mouse Knockout α Hnf-1 Diabetes Mellitus in the Laron Dwarfism and Non-Insulin-Dependent (1998) (2)
Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice (2020) (2)
Peroxisome proliferator-activated receptor- b / d (PPAR b / d ) ligands do not potentiate growth of human cancer cell lines (2007) (2)
Low-cost embedded system for optical imaging of intrinsic signals (2019) (2)
Bile Acid Sequestration Reverses Liver Injury and Prevents Progression of NASH in Western Diet-Fed Mice (2020) (2)
1 METABOLOMICS REVEALS ATTENUATION OF THE SLC 6 A 20 KIDNEY TRANSPORTER IN NONHUMAN PRIMATE AND MOUSE MODELS OF TYPE 2 DIABETES MELLITUS (2011) (2)
Regulation of Squamous Cell Carcinoma Carcinogenesis by Peroxisome Proliferator-Activated Receptors (2011) (2)
Role of HNF4α in the superinduction of the IL-1β-activated iNOS gene by oxidative stress (2006) (2)
Endothelial Cell–Targeted Deletion of PPARγ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue (2019) (2)
CYP2E1 is not involved in early alcohol-induced liver injury. (1999) (1)
Stable expression of human cytochrome P450 cDNAs in human lymphoblastoid cells (1992) (1)
The PXR-humanized Mouse: A Model for Investigating Drug- drug Interactions Mediated by Cytochromes P450 3A (2006) (1)
Improved drug therapy: triangulating phenomics with genomics and metabolomics (2014) (1)
HYPOXIA INDUCIBLE FACTOR 1ALPHA (HIF-1ALPHA) IS REQUIRED FOR SUCCESSFUL ISLET TRANSPLANTATION AND INCREASING HIF-1ALPHA WITH DESFERRIOXAMINE MARKEDLY IMPROVES OUTCOMES: 401 (2008) (1)
Abstract 23: Nuclear receptor PPARα activation triggers hepatic cell death in Ikkβ-deficient mice (2015) (1)
Abstracts from 8th International ISSX Meeting (2007) (1)
A natural product that lowers cholesterol as an antagonist for the bile acid receptor FXR (2003) (1)
Therapeutic Discovery Chemoprevention of Chemically Induced Skin Tumorigenesis by Ligand Activation of Peroxisome Proliferator – Activated Receptor-b / d and Inhibition of Cyclooxygenase 2 (2010) (1)
Regulation of Xenobiotic-Metabolizing Cytochromes P450 (1994) (1)
Hereditary polymorphisms of human drug metabolizing enzymes and cancer susceptibility. (1990) (1)
TGF-- SMAD 3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury (1)
4-Dehydrodebrisoquine , a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP 2 D 6 Metabolic Ratio (2006) (1)
Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting (2022) (1)
Correction: Hypoxia-Inducible Factor Directs POMC Gene to Mediate Hypothalamic Glucose Sensing and Energy Balance Regulation (2016) (1)
Oleuropein-Induced Acceleration of Cytochrome P450–Catalyzed Drug Metabolism: Central Role for Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (2021) (1)
The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice (2022) (1)
Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens (2022) (1)
PPARg in the endothelium regulates metabolic responses to high-fat diet in mice (2018) (1)
Human Cytochromes P450: Regulation and Functional Variability (1995) (1)
Manassantin B attenuates obesity by inhibiting adipogenesis and lipogenesis in an AMPK dependent manner (2021) (1)
Involvement of multiple cytochrome p450 isoforms in naproxen demethylation (1996) (1)
Fenofibrate Metabolism in the Cynomolgus Monkey using UPLC-QTOFMS Based (2009) (1)
Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/ b-Catenin Signaling (2019) (1)
Abstract 4320: Circulating vitamin D2 and D3 levels and single nucleotide polymorphism associations with lung cancer status: A case-control study (2016) (1)
Hepatocyte nuclear factor-1α (HNF-1α) differentially regulates lactase-phlorizin hydrolase (LPH) gene expression during weaning in mice (2003) (1)
The acyl-CoA thioesterase I (Acot1) is regulated by the peroxisome proliferator-activated receptor alpha and hepatocyte nuclear factor 4 alpha via a distal response element in the promotor (2017) (1)
Deficiency of peroxisome proliferator-activated receptor α attenuates apoptosis and promotes migration of vascular smooth muscle cells (2021) (1)
Contribution of individual P 450 isozymes to the O-demethylation of the psychotropic β-carboline alkaloids harmaline and harmine (2002) (1)
73 Adaptive renal ABC transporter expression in common bile duct-ligated mice (2004) (1)
Rifampicin-Activated Human PXR and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity (2009) (1)
Phenotyping と Genotyping の臨床的意義 (1996) (1)
1106 Hepatic and renal ABC transporter expression as critical determinants of ursodeoxycholic acid-induced bile infarcts in bile duct-ligated mice (2003) (1)
Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed Fxr-null mice : FXR-independent suppression of intestinal bile acid absorption (2008) (1)
Disruption of peroxisome proliferator-activated receptor α in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway (2022) (1)
HNF4A is required to specify glucocorticoid action in the liver (2021) (1)
Marked increase in P450IA1 and P450IA2 gene expression in congenitally jaundiced gunn rats (1990) (1)
Hepatic Fibrosis in Ahr-/- Mice (1996) (1)
Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity (2016) (1)
PPARD regulates ERK signaling in the testis (2015) (1)
Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in mouse liver (2022) (1)
Mechanisms of Hypoxie and Aerobic Cytotoxicity of Mitomycin C in Chinese Hamster V79 Cells1 (2006) (1)
ISN Forefronts Symposium 2015: Nuclear Receptors and Diabetic Nephropathy (2016) (1)
Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum (2013) (0)
日本人におけるCYP2D6のさらなる新しい遺伝子変異(CYP2D6C8)の発見 (1997) (0)
Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites (2020) (0)
Withaferin A Improves Nonalcoholic Steatohepatitis in Mice s (2019) (0)
Glycine‐β‐muricholic acid antagonizes the intestinal farnesoid X receptor–ceramide axis and ameliorates NASH in mice (2022) (0)
DMD # 8920 3 , 4-DEHYDRODEBRISOQUINE , A NOVEL DEBRISOQUINE METABOLITE FORMED FROM 4-HYDROXYDEBRISOQUINE THAT IMPACTS THE CYP 2 D 6 METABOLIC RATIO (2006) (0)
Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in the liver (2022) (0)
THE STUDY OF XENOBIOTIC-METABOLIZING ENZYMES AND THEIR ROLE IN DRUG METABOLISM AND TOXICITY USING TARGETED GENE DISRUPTION (1998) (0)
Abstract 1211: Hif-1{alpha} In T Cells Pathway Plays A Crucial Role In The Progression Of Arteriosclerosis And Artery Intimal Thickening (2007) (0)
Modulation of metabolic diseases through control of intestinal ceramide synthesis:The emergence of new drug targets in the gut (2019) (0)
Polyamine metabolism links gut microbiota and testicular dysfunction (2021) (0)
Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response (2023) (0)
Mo1789 Hepatocyte Nuclear Factor 4α Regulates the Human Na+/H+ Exchanger Isoform-3 Expression in Intestine (2013) (0)
Bioengineered microRNA-1291 effects on pancreatic cancer cell proliferation and xenograft tumor growth. (2018) (0)
Hypoxia-inducible factor 2alpha activation disrupts cholesterol metabolism homeostasis of liver and accelerates atherosclerosis in apoE-null mice (2013) (0)
A Western diet-induced mouse model reveals a possible mechanism by which metformin decreases obesity (2017) (0)
PPAR (cid:1) attenuates the proinﬂammatory response in activated mesangial cells (2009) (0)
Abstract 2172: Anti-oncogenic role of peroxisome proliferator-activated receptor-α/β (PPARδ/α) involves inhibition of mitosis and regulation of Hras1-induced senescence (2012) (0)
SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis (2020) (0)
Hepatocyte Nuclear Factor 4α Regulates the Expression of Intestinal Epithelial Na+/H+ Exchanger Isoform-3 (NHE3) (2017) (0)
Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer (2022) (0)
Investigating the roles of lipids in disease and chemical toxicities using metabolomics (2011) (0)
Inhibition of Cytochrome P450 1B1 Prevents Hepatic Stellate Cell Activation and Liver Fibrosis (2021) (0)
CYP2D6 genotype and steady-state plasma concen tration (Css) of trazodone (1998) (0)
Abstract 5824: Fully-humanized, bioengineered miR-1291 modulates key nutrient transport and metabolism to control tumor metabolism (2022) (0)
Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for Cancer Chemoprevention (2015) (0)
Immortalized human cell lines containing cytochrome p450 genes exogenous. (1993) (0)
Hypoxia inducible factor 2α inhibition in vascular smooth muscle cells (VSMCs) abolishes abdominal aortic aneurysm in ApoE−/− mice (2020) (0)
LC–MS-based metabolomics: an update (2014) (0)
The United States–Japan workshop on: The role of nuclear receptors in carcinogenesis (2004) (0)
The role of miRNAs in PPARalpha induced hepatocellular carcinomas (2010) (0)
Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins (2022) (0)
Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice (2013) (0)
Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity (2014) (0)
Cytochrome P450s and molecular epidemiology (1993) (0)
PPARα via HNF4α regulates the expression of genes encoding hepatic amino acid catabolizing enzymes to maintain metabolic homeostasis (2015) (0)
Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs. (2023) (0)
Thymic Involution-dioxin-Induced p 2 , 3 , 7 , 8-Tetrachlorodibenzo-Causes Resistance to ) Gene Arnt Receptor Nuclear Translocator ( T Cell-Specific Disruption of Arylhydrocarbon and Yousuke (2003) (0)
Abstract 2500: Urinary metabolites are diagnostic biomarkers of liver cancer (2017) (0)
In situ intestinal perfusion in PXR/CYP3A4-humanized mice: the effect of rifampicin on darunavir absorption (2012) (0)
Reply: (2012) (0)
Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome (2019) (0)
Protection from liver toxicity induced by lithocholic acid-feeding : Involvement of cyp3a and hydroxysteroid sulfotransferase(Drug metabolism, Proceedings of the 32nd Annual Meeting) (2005) (0)
Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling (2019) (0)
Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease (2013) (0)
Abstract 345: Role Of Vascular Smooth Muscle Cell PPARγ In Aldosterone-induced Vascular Injury (2014) (0)
The Role of PPARα in Fatty Acid Metabolism and Hepatocarcinogenesis: Studies with PPARα-Null Mice (2002) (0)
during acute renal failure -modulated enzymes protect α Etomoxir-induced PPAR (2016) (0)
Hepatic fibrosis: targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. (2023) (0)
Bile acid sulfates as a possible early marker of liver toxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting) (2005) (0)
Prevention of acetaminophen (APAP) covalent binding and toxicity in CYP-1A2 and CYP-2E1, double-knockout mice (1998) (0)
Cyp1a2‐knockout increases the systemic exposure of a serotonin and norepinephrine reuptake inhibitor duloxetine in mice (2022) (0)
Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice (2020) (0)
Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation (2017) (0)
Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome (2019) (0)
The role of toxic lipids metabolic disease (2017) (0)
Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice (2018) (0)
Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis (2021) (0)
The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation (2018) (0)
Modulation of fatty acid and bile acid metabolism by PPAR α protects against alcoholic liver disease (2014) (0)
Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment (2019) (0)
Results Intestine-Specific Disruption of Vhl , Arnt , and Hif-1 Genes via Cre-loxP – Mediated Recombination in Mice (2008) (0)
Peroxisome proliferators-activated receptor α controls tryptophan-NAD metabolism in rodents (2007) (0)
Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene (2016) (0)
Metabolomic and Genetic Analysis of Biomarkers for PPAR α Expression and Activation (2007) (0)
Clozapine pharmacokinetics studied with CYP1A2 knockout mice (2000) (0)
association with liver and adipose tissue effects -- of FGF21 in insulin-resistant mouse models Acute glucose-lowering and insulin-sensitizing action (2011) (0)
6β-Hydroxytestosterone Promotes Angiotensin II-Induced Hypertension via Enhanced Cytosolic Phospholipase A2α Activity (2021) (0)
Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis (2019) (0)
Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming (2018) (0)
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice (2023) (0)
Abstract 15250: Peroxisome Proliferator Activated Receptor-Gamma Regulates Trans-endothelial Fatty Acid Transport via Induction of Fatty Acid Binding Protein 4 and Fatty Acid Translocase in Capillary Endothelial Cells in Heart and Adipose Tissue (2010) (0)
PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice. (2023) (0)
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin (2018) (0)
Fenofibrate induced‐hepatomegaly and liver regeneration is PPARα dependent and partially related to the activation of YAP pathway (2022) (0)
Abstract 343: Endothelin-1 Overexpression Preserves Endothelial Function In Mice With Vascular Smooth Muscle Cell-specific Deletion Of Ppar-gamma (2014) (0)
Role of the peroxisome proliferator‐activated receptor-α in the down regulation of fibrinogen gene expression in rodents (1998) (0)
Use Of Microarray Expression Profiling To Investigate The Mechanism Of Hepatocarcinogenesis Induced By The Peroxisome Proliferator Diethylhexylphthalate (DEHP) In Mice (2000) (0)
Abstract MP250: Reduction In Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator (arnt) Mediates Vascular Dysfunction In Mice With Type 2 Diabetes Mellitus (2021) (0)
Analysis of the selenocysteine (Sec) tRNA population in mouse embryonic stem (ES) cells heterozygous for the Sec tRNA gene (1997) (0)
AHR-mediated suppression of PPARα target gene expression caused by exposed polycyclic aromatic hydrocarbons (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting) (2003) (0)
Abstract 6057: Association of liver cancer and chronic liver disease with urinary glyphosate and its metabolites in Thailand (2023) (0)
Correction to "Novel Strategy for Mining and Identification of Acylcarnitines Using Data-Independent-Acquisition-Based Retention Time Prediction Modeling and Pseudo-Characteristic Fragmentation Ion Matching". (2021) (0)
186 - Redox Activation of LKB1/AMPK Pathway Protects Against Alcohol-Induced Steatosis (2015) (0)
Abstract 1850: Transcription factor E2F3 up-regulates the expression of Gadd45b gene in the mouse liver (2016) (0)
Development and application of human cell lines engineered to metabolically activate structurally diverse environmental mutagens (1993) (0)
Bile Acids and the Gut Liver Axis (2017) (0)
Procede et compositions de detection des mutations a epissage de la dihydropyrimidine deshydrogenase (1997) (0)
Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH. (2020) (0)
Corrigendum to ``New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases'' [Chemosphere 144C (2015) 1966-1972] (2016) (0)
Abstract 3436: Endothelial PPAR{gamma} Regulates Lipid Metabolism And Adiposity After High Fat Feeding (2008) (0)
Cytochrome P-450 3A4 (Nifedipine Oxidase) Is Responsible for the C-oxidative Metabolism of 1-Nitropyrene in Human Liver Microsomal Samples1 (2006) (0)
Mutagenic Heterocyclic Amines Tester Strain Highly Sensitive to Salmonella Establishment of a Updated (2006) (0)
Functional analysis of nuclear receptor HNF4γ (2016) (0)
Corrigendum to: Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells. (2021) (0)
Characterization of urine metabolic profiles of farnesoid X receptor-null mice exhibiting spontaneous hepatocarcinogenesis using mass spectrometry-based metabolomics (2008) (0)
Peroxisome Proliferator-Activated Receptor Regulation of Human ApoA-I by Gemfibrozil and Fenofibrate Through Selective (2005) (0)
Expression of hydroxysteroid sulfotransferase involved in protection against bile acid-induced hepatotoxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting) (2005) (0)
Immortalized human cell lines which exogenous cytochrome P-450 gen contained (1994) (0)
The intestinal FXR-mediated Fgf-115 pathway contributes to the diurnal control of hepatic bile acid synthesis and bile formation in chow fed mice but its contribution is overruled during bile acid feeding and bile acid sequestration (2009) (0)
Clofibrate-induced cytochrome P450-lauric acid omega hydroxylase(P450LA omega):purification, cDNA cloning, sequence and regulation (1986) (0)
Identification of a novel CYP2D6 allele associated with poor metabolism of sparteine in a Japanese population. (1991) (0)
SR-BI involved on plasma HDL2-apoA-I recirculation to preβ-HDL in mice (2016) (0)
Identification and Detection of a New Polymorphic CYP2D6 Allele in a Japanese Population (1995) (0)
Abstract P035: Endothelin-1 Overexpression Preserves Endothelial Function in Mice with Vascular Smooth Muscle Cell-specific Deletion of Ppar-gamma (2015) (0)
Assignment of dioxin-inducible cytochrome P-450 gene family to Chinese hamster chromosome 4 (1985) (0)
CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS (2010) (0)
sphenanthera extract ) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF 2-ARE and p 53 / p 21 pathways (2014) (0)
S2-5 Disruption of Growth Hormone Signal Caused by Polycyclic Aromatic Hydrocarbons. (2001) (0)
Reversal of liver fibrosis in aryl hydrocarbon receptor knockout mice by vitamin A depletion (2003) (0)
Abstract 4366: Characterization of diacetylspermine as a metabolic urinary biomarker in breast cancer using patient-derived xenografts (2019) (0)
[A change in glomerular permeability in renovascular hypertension. Participation of angiotensin and structural lesions]. (1986) (0)
Establishment and toxicological application of a cell line expressing human CYP2E1 (1996) (0)
Intestinal FXR: A New Therapeutic Target for Nonalcoholic Fatty Liver Disease (2015) (0)
by Plasma Metabolomics and Lipid Profiling Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed (2011) (0)
Cytochrome P-450 3 A 4 ( Nifedipine Oxidase ) Is Responsible for the C-oxidative Metabolism of 1-Nitropyrene in Human Liver Microsomal Samples 1 (2006) (0)
The role of the bile acid receptor FXR in determining ATP-binding cassette (ABC) transporter expression and liver injury in common bile duct-ligated (CBDL) mice (2003) (0)
Peroxisome Proliferator-Activated Receptor (cid:2) Regulates a MicroRNA-Mediated Signaling Cascade Responsible for Hepatocellular Proliferation (cid:1) † (2007) (0)
Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice (2011) (0)
Mechanisms for constitutive and developmental regulation of rat hepatic cytochrome P450 genes (1992) (0)
Discovery of new mutation of CYP2D6 in the Japanese and their gene diagnosis. (1995) (0)
Abstract 1901: Untargeted metabolomic profiling identifies diagnostic and prognostic biomarkers of lung cancer. (2013) (0)
Human Placental Lactogen Induces CYP 2 E 1 Expression via PI 3-Kinase Pathway in Female Human Hepatocytes s (2014) (0)
Molecular and Cellular Pathobiology Hypoxia-Inducible Factor-2 a Activation PromotesColorectal Cancer Progression by Dysregulating Iron Homeostasis (2012) (0)
Analysis Activities of Human Cytochrome and Expression P 450 Catalytic (2006) (0)
Abstract 461: Hepatic Nuclear Factor 4 Alpha as a Regulator of Alanine: Glyoxylate Aminotransferase 2 Expression and Systemic Levels of Endogenous Methylarginines (2016) (0)
Use of microarray expression profiling in PPARα null and wild-type mice to investigate the mechanism of hepatocarcinogenesis induced by the Peroxisome Proliferator diethylhexylphthalate (DEHP) (2000) (0)
Understanding Molecular Mechanisms of Toxicity and Carcinogenicity Using Gene Knockout and Transgenic Mouse Models (2004) (0)
MPS 18-02 ENDOTHELIN-1 OVEREXPRESSION PRESERVES ENDOTHELIAL FUNCTION IN MICE WITH VASCULAR SMOOTH MUSCLE CELL-SPECIFIC DELETION OF PPAR-GAMMA (2016) (0)
Localization and Expression of the Eicosanoid Metabolizing P4501VA Gene Family in Rat Tissues and Hepatic Tumors (1991) (0)
METABOLOMICS OF FENOFIBRATE IN CYNOMOLGUS MONKEY (2008) (0)
miRNA-mediated transcriptional regulation by hepatic HNF4α (2016) (0)
PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate. (2017) (0)
Protection against SR 4233 aerobic cytotoxicity by the metal chelators desferrioxamine and tiron (1993) (0)
Abstract 1295: Inhibition of clonogenicity and xenograft tumor growth by activation and/or over-expression of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). (2013) (0)
456 Farnesoid X receptor (FXR) transactivates mouse organic anion transporting polypeptide 4 (OATP4, SLC21A10, LST-1) promoter: In vitro and in vivo evidence (2003) (0)
Transgenic frequency of Japanese human CYP2D6. (1996) (0)
Activation of PPAR-a:RXRa pathway upregulates tripeptidyl peptidase 1 in brain cells: Implications for late infantile neuronal ceroid lipofuscinosis therapy (2013) (0)
LC‐MS‐based metabolomics of acetaminophen‐induced acute toxicity (2009) (0)
Geneticallay engineered cells harbouring human P450 isoforms (1995) (0)
Cytochrome P-450 Function Analyses with Monoclonal Antibodies and cDNA Expression Vectors (1988) (0)
Peroxisome Proliferation-Activated Receptor (PPAR) (cid:1) Is Not Necessary for Synthetic PPAR (cid:1) Agonist Inhibition of Inducible Nitric-Oxide Synthase and Nitric Oxide (2004) (0)
Influence of Conjugated Linoleic Acid (CLA) in Peroxisome Proliferator-Activated Receptor Alpha-null Mice (Abstract, 220: 24-AGFD)) (2000) (0)
Abstract 935: Lung cancer metabolomics identifies metabolites as robust risk biomarkers (2015) (0)
Abstract 1227: Anti-oncogenic role of Peroxisome proliferator-activated receptor- β/Δ (Pparβ/Δ) involves regulation of viral Hras1 (v-Hras1)-induced senescence and endoplasmic reticulum (ER) stress in mouse primary keratinocytes (2011) (0)
Re-differentiation of hepatoma cells by a novel HNF4γ variant (2017) (0)
Metabolomics reveals 1‐methylnicotinamide and nicotinamide N‐methyltransferase as crucial biomarkers in microRNA‐1291‐altered pancreatic carcinoma cell metabolism (1147.1) (2014) (0)
Alterations in skin and stratified epithelia by constitutively activated PPARα. Commentary (2006) (0)
6β-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice (2020) (0)
Cytochrome P450 evoluation and nomenclature (1993) (0)
Abstract 322: Selective inhibition of MYC expression by a small molecule G-quadruplex stabilizer (2016) (0)
II-induced hypertension in female mice angiotensin renal dysfunction and damage associated with -450 1B1 gene exacerbates P Disruption of the cytochrome (2016) (0)
Intermittent Fasting Prom otes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota Graphical Abstract Highlights (2017) (0)
Response: hepatic fibrosis in ahr-/- mice. (1996) (0)
Metabolomics illustrates celastrol-mediated suppression on colitis (2017) (0)
Supplemental Data for Metabolic profiling of the novel HIF 2 α inhibitor PT 2385 in vivo and in vitro in Drug Metabolism and Disposition (2018) (0)
HNF4αはmiR-194/192を介して肝細胞の脱分化を抑制する (2015) (0)
Fxr But Not Tgr5 Activation Stimulates Hco3-Rich Bile Secretion And Ameliorates Liver Damage In Mdr2-/- (Abcb4-/-) Mouse Model Of Chronic Liver Injury (2011) (0)
FUNCTIONAL CHARACTERIZATON, TISSUE DISTRIBUTION AND IMMUNOLOCALIZATION OF RAT H/ORGANIC CATION ANTIPORTER MATE1 (2006) (0)
Abstract 715: Cytochrome P450 1B1 Gene Disruption Prevents Neointimal Growth in Wire-Injured Carotid Artery of Male Mice (2015) (0)
Abstract 2700: Intestinal Vitamin D receptor deficiency increases susceptibility for the DSS-induced colon disease (2017) (0)
Development of pharmacogenetics and clinical pharmacology. From molecular level to clinical medicine and drug development. Clinical significance of phenotyping and genotyping. (1996) (0)
Constitutive androstane receptor promoted- hepatomegaly and liver regeneration is partially via yes-associated protein activation (2020) (0)
Choline Kinase Alpha Mediates Interactions Between the Epidermal Growth Factor Receptor and mTORC 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression Short Title : Role of CHKA in HCC Progression (2017) (0)
Regulation of the Liver Fatty Acid Binding Protein Gene (L-FABP) by Hepatocyte Nuclear Factor 1 αααα . ALTERATIONS IN FATTY ACID HOMEOSTASIS IN HNF1 α - DEFICIENT MICE (2000) (0)
Constitutive androstane receptor negatively regulates human apolipoprotein A-1 expression (2005) (0)
Erratum: Transcription coactivator PBP, the peroxisome proliferator- activated receptor (PPAR)-binding protein, is required for PPARα-regulated gene expression in liver (Journal of Biological Chemistry (2004) 279 (24427-24434)) (2004) (0)
Bile acid-induced liver toxicity and nuclear receptor FXR (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting) (2003) (0)
Abstract 5552: Notch-peroxisome Proliferator Activated Receptor Gamma 2 Pathway Regulates Transendothelial Fatty Acid Transport via Induction of Fatty Acid Binding Protein 4 and Fatty Acid Translocase in Capillary Endothelial Cells in Heart (2009) (0)
Abstract 16681: Hepatic Nuclear Factor 4 Alpha is the Major Regulator of Alanine:Glyoxylate Aminotransferase 2 Expression - A Novel Link Between Diabetes and Impaired Metabolism of Nitric Oxide and Lipids (2014) (0)
Knockout mice to study the role of CYP1B1 in carcinogenesis in vivo (1998) (0)
Spinning the Spatiotemporal Profile of Transcription Factors Via Intermittent Fasting (2020) (0)
Genetically-engineered animals in the study of cytochromes P450 and carcinogenesis (1998) (0)
Abstract 15414: Ablation of Aryl Hydrocarbon Nuclear Translocator (ARNT) in the Heart Leads to Diabetic Cardiomyopathy Phenotype Through PPARα Activity (2014) (0)
Abstract 551: Deficiency of Hepatic Nuclear Factor 4 Alpha Results in Impaired Metabolism of Endogenous Methylarginines and Beta-aminoisobutiric Acid - A Novel Mechanism of Cardiovascular Complications in Patients With Type 2 Diabetes? (2015) (0)
Impact of NAD(P)H:quinone Oxidoreductase 1 (NQO1) on Quinone Reduction During Passage Through the Mouse Pulmonary Circulation (2010) (0)
Abstract PR02: Diagnostic and prognostic utility of urinary creatine riboside for early stage non-small cell lung cancer (2018) (0)
- Null Mice α Peroxisome Proliferator-Activated Receptor Receptor and Nonreceptor-Mediated Organ-Specific Toxicity of Di ( 2-ethylhexyl ) phthalate ( DEHP ) in (2009) (0)
Analysis of the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) cistrome reveals novel co-regulatory role of ATF4 (2012) (0)
Contents Silver Spoons and Other Personal Reflections (2013) (0)
Metabolisme defectueux de medicaments (1995) (0)
Peroxisome Proliferator-Activated Receptors- (cid:1) and - (cid:2) , and cAMP-Mediated Pathways, Control Retinol-Binding Protein-4 Gene Expression in Brown Adipose Tissue (2012) (0)
Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence (2023) (0)
1236 FXR IS A KEY PLAYER IN NAFLD DEVELOPMENT BY CONTROLLING CHOP EXPRESSION (2012) (0)
Targeted disruption of the nucleosomal binding protein HMGN5 results in altered glutathione metabolism and mild hepatic dysfunction (2013) (0)
New biology for engineers and computer scientists [Book Review] (2004) (0)
Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat (2014) (0)
Mesenchymal stem cell derived exosomes in the treatment of synovitis: proof of concept in large animal model (2016) (0)
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer (2023) (0)
Inhibition of estrogen sulfation by Xian-Ling-Gu-Bao capsule (2022) (0)
Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury (2016) (0)
Metabolomics Reveals the role of hypoxia‐inducible factors in hypoxia‐induced liver metabolic shift (2012) (0)
Role of the Pregnane X Receptor in the Clinical Resistance to all‐trans Retinoic Acid (2007) (0)
A Metabolomic Investigation of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) Metabolism in the Mouse (2007) (0)
Rifaximin Protection of DSS‐Induced Inflammatory Bowel Disease by Inhibition of Nuclear Factor Kappa B through Activation of Human Pregnane X Receptor (2010) (0)
41 Cholesterol 7α-Hydroxylase (CYP7A1) Mediates Resistance to High-Fat Diet-Induced Obesity and Diabetes Through Elevated Tauro-β-Muricholic Acid and Inhibition of Farnesoid X Receptor Signaling in the Intestine (2014) (0)
The effect of pregnane X receptor (PXR)‐mediated CYP3A induction on acetaminophen hepatotoxicity (2007) (0)
Metabolomic analysis of the Hepatocyte Nuclear Factor 1 Alpha knockout mouse (2010) (0)

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