Frank Michael Laferla

Frank Michael Laferla's AcademicInfluence.com Rankings

Biology

#6755

World Rank

#9541

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Neuroscience

#824

World Rank

#858

Historical Rank

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Biology

Frank Michael Laferla's Degrees

PhD Neuroscience University of California, Irvine
Masters Biology University of California, Irvine
Bachelors Biology University of California, Irvine

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Frank Michael Laferla's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Intracellular Aβ and Synaptic Dysfunction (2003) (3694)
Intracellular amyloid-β in Alzheimer's disease (2007) (1577)
Alzheimer's disease. (2010) (1351)
Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice (2005) (1192)
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (1073)
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease (2002) (957)
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer’s disease (2003) (938)
Intracellular amyloid-beta in Alzheimer's disease. (2007) (849)
Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome (2004) (812)
Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease (2009) (784)
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (2017) (693)
Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease (2005) (610)
The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice (1995) (552)
Glucocorticoids Increase Amyloid-β and Tau Pathology in a Mouse Model of Alzheimer’s Disease (2006) (548)
Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders (2000) (517)
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. (2004) (498)
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease (2010) (490)
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease (2007) (480)
M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice (2006) (403)
Alzheimer's disease: Aβ, tau and synaptic dysfunction (2005) (382)
Synergistic Interactions between Aβ, Tau, and α-Synuclein: Acceleration of Neuropathology and Cognitive Decline (2010) (371)
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome (2009) (369)
Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal β-Catenin Pathway Function in an Alzheimer’s Disease Model (2011) (352)
Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease (2006) (348)
Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease (2008) (347)
Animal models of Alzheimer disease. (2012) (345)
Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau (2008) (344)
Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-β and Tau Pathology via a Mechanism Involving Presenilin 1 Levels (2007) (339)
Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice (2000) (338)
Aβ inhibits the proteasome and enhances amyloid and tau accumulation (2008) (324)
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis (2012) (308)
Enhanced Ryanodine Receptor Recruitment Contributes to Ca2+ Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice (2006) (305)
A mitochondrial etiology of Alzheimer and Parkinson disease. (2012) (303)
Progesterone and Estrogen Regulate Alzheimer-Like Neuropathology in Female 3xTg-AD Mice (2007) (302)
Reduction of Soluble Aβ and Tau, but Not Soluble Aβ Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles* (2006) (295)
Sustained Interleukin-1β Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model (2013) (293)
Linking Calcium to Aβ and Alzheimer's Disease (2008) (289)
Age- and region-dependent alterations in Aβ-degrading enzymes: implications for Aβ-induced disorders (2005) (272)
Dysregulated IP3 Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation in Presenilin1 Results in Exaggerated Ca2+ Signals and Altered Membrane Excitability (2004) (268)
Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony (2017) (268)
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice (2007) (263)
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP (2002) (249)
Altered Expression of Diabetes-Related Genes in Alzheimer's Disease Brains: The Hisayama Study (2013) (245)
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model (2008) (241)
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology (2009) (241)
Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer’s Disease1 (2009) (238)
Controlled Cortical Impact Traumatic Brain Injury in 3xTg-AD Mice Causes Acute Intra-Axonal Amyloid-β Accumulation and Independently Accelerates the Development of Tau Abnormalities (2011) (235)
Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. (2006) (232)
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice (2005) (229)
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production (2008) (226)
Physical exercise protects against Alzheimer's disease in 3xTg-AD mice. (2011) (226)
Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: A role for intraneuronal amyloid (2007) (210)
A Dynamic Relationship between Intracellular and Extracellular Pools of Aβ (2006) (200)
Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. (2007) (200)
Ibuprofen reduces Aβ, hyperphosphorylated tau and memory deficits in Alzheimer mice (2008) (199)
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. (2010) (197)
Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study (2009) (196)
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2019) (194)
Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony (2013) (194)
Pathways by which Abeta facilitates tau pathology. (2006) (192)
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease (2018) (190)
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. (2005) (189)
Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. (2008) (187)
Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes (2010) (186)
Alzheimer's disease: Abeta, tau and synaptic dysfunction. (2005) (180)
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD (2010) (179)
Congo red and thioflavin‐T analogs detect Aβ oligomers (2007) (179)
Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes (2010) (173)
Collapsin response mediator protein‐2 hyperphosphorylation is an early event in Alzheimer’s disease progression (2007) (172)
Inflammation induced by infection potentiates tau pathological features in transgenic mice. (2011) (172)
Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. (1997) (171)
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. (2008) (170)
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation (2015) (168)
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage (2007) (164)
Phosphorylation of Actin-Depolymerizing Factor/Cofilin by LIM-Kinase Mediates Amyloid β-Induced Degeneration: A Potential Mechanism of Neuronal Dystrophy in Alzheimer's Disease (2006) (163)
Intraneuronal β-Amyloid Accumulation in the Amygdala Enhances Fear and Anxiety in Alzheimer's Disease Transgenic Mice (2010) (159)
Enhanced caffeine‐induced Ca2+ release in the 3xTg‐AD mouse model of Alzheimer's disease (2005) (159)
Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice (2010) (159)
Neural Stem Cells Improve Memory in an Inducible Mouse Model of Neuronal Loss (2007) (158)
Relevance of Transgenic Mouse Models to Human Alzheimer Disease* (2009) (156)
Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss (2015) (155)
Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice (2008) (152)
The Role of Tau in Alzheimer's Disease and Related Disorders (2011) (149)
Diabetes and Alzheimer’s disease crosstalk (2016) (148)
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. (2002) (146)
Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals. (2005) (143)
Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. (2013) (142)
Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. (2005) (142)
Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions. (2012) (140)
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. (2014) (140)
Androgens Regulate the Development of Neuropathology in a Triple Transgenic Mouse Model of Alzheimer's Disease (2006) (138)
Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice (2010) (138)
Presenilin Is Necessary for Efficient Proteolysis through the Autophagy–Lysosome System in a γ-Secretase-Independent Manner (2011) (135)
Presenilin-2 Mutations Modulate Amplitude and Kinetics of Inositol 1,4,5-Trisphosphate-mediated Calcium Signals* (1999) (134)
The role of nicotinic acetylcholine receptors in Alzheimer’s disease (2006) (133)
Alzheimer's Presenilin-1 Mutation Potentiates Inositol 1,4,5-Trisphosphate-Mediated Calcium Signaling in Xenopus (1999) (132)
Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD (2009) (127)
Learning Decreases Aβ*56 and Tau Pathology and Ameliorates Behavioral Decline in 3xTg-AD Mice (2007) (120)
Microglia as a Potential Bridge between the Amyloid β‐Peptide and Tau (2004) (119)
Blocking Aβ42 Accumulation Delays the Onset and Progression of Tau Pathology via the C Terminus of Heat Shock Protein70-Interacting Protein: A Mechanistic Link between Aβ and Tau Pathology (2008) (119)
Inclusion body myositis-like phenotype induced by transgenic overexpression of βAPP in skeletal muscle (2002) (118)
Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease. (2011) (116)
A dynamic relationship between intracellular and extracellular pools of Abeta. (2006) (115)
Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. (2004) (110)
Soluble Aβ Promotes Wild-Type Tau Pathology In Vivo (2012) (110)
Enhanced Ryanodine‐Mediated Calcium Release in Mutant PS1‐Expressing Alzheimer's Mouse Models (2007) (110)
Phosphorylation of Threonine 3 (2009) (108)
Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. (1996) (108)
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. (2010) (106)
Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling (2001) (105)
Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation (2017) (100)
Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease. (2012) (100)
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models (2014) (100)
7,8-Dihydroxyflavone, a Small Molecule TrkB Agonist, Improves Spatial Memory and Increases Thin Spine Density in a Mouse Model of Alzheimer Disease-Like Neuronal Loss (2014) (99)
Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models (2010) (99)
Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer’s disease (2013) (97)
Ca2+ Signaling in Mouse Cortical Neurons Studied by Two-Photon Imaging and Photoreleased Inositol Triphosphate (2003) (97)
Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. (2011) (96)
Soluble Amyloid Precursor Protein Induces Rapid Neural Differentiation of Human Embryonic Stem Cells (2011) (95)
Congo red and thioflavin-T analogs detect Abeta oligomers. (2008) (95)
Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease (2009) (94)
Calsenilin reverses presenilin-mediated enhancement of calcium signaling. (2000) (94)
Mifepristone Alters Amyloid Precursor Protein Processing to Preclude Amyloid Beta and Also Reduces Tau Pathology (2013) (90)
Age-related accumulation of Reelin in amyloid-like deposits (2009) (86)
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. (2020) (86)
Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease (2012) (85)
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice (2010) (85)
Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus (2015) (85)
Validation of a 2-day water maze protocol in mice (2009) (83)
Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease (2014) (83)
Formulation of a Medical Food Cocktail for Alzheimer's Disease: Beneficial Effects on Cognition and Neuropathology in a Mouse Model of the Disease (2010) (83)
Genetically augmenting tau levels does not modulate the onset or progression of Aβ pathology in transgenic mice (2007) (82)
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. (2010) (82)
Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's A beta peptide. (2000) (82)
Inflammation induces tau pathology in inclusion body myositis model via glycogen synthase kinase‐3β (2008) (81)
Spatial Frequency Domain Imaging of Intrinsic Optical Property Contrast in a Mouse Model of Alzheimer’s Disease (2011) (80)
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice. (2012) (80)
Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐AD mice (2015) (79)
Systemic vaccination with anti‐oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg‐AD mice (2013) (78)
Amyloid-beta peptides stimulate the expression of the p75(NTR) neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. (2010) (78)
Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease (2009) (77)
Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease (2021) (75)
Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice. (2014) (74)
Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. (2006) (72)
Accelerating stem cell trials for Alzheimer's disease (2016) (72)
Pathways linking Abeta and tau pathologies. (2010) (71)
Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease (2014) (71)
Microglia as a potential bridge between the amyloid beta-peptide and tau. (2004) (70)
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease. (2013) (69)
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. (2014) (68)
Amyloid β-Peptide: The Inside Story (2004) (68)
Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid* (2012) (67)
Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to Alzheimer’ β amyloid peptide (2000) (67)
Brain Gene Expression of a Sporadic (icv-STZ Mouse) and a Familial Mouse Model (3xTg-AD Mouse) of Alzheimer’s Disease (2012) (64)
Alzheimer's Presenilin‐1 Mutation Potentiates Inositol 1,4,5‐Trisphosphate‐Mediated Calcium Signaling in Xenopus (1999) (63)
Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models. (2007) (61)
Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice (2017) (61)
Regional hypomyelination and dysplasia in transgenic mice with astrocyte-directed expression of interferon-γ (2000) (61)
Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle (2009) (60)
Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain. (1996) (59)
Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling (2001) (58)
13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro (2011) (57)
M1 agonists as a potential disease-modifying therapy for Alzheimer's disease. (2009) (55)
Anesthesia in presymptomatic Alzheimer’s disease: A study using the triple-transgenic mouse model (2011) (54)
Phosphorylation of Threonine 3 IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY (2009) (54)
Chronic Temporal Lobe Epilepsy Is Associated with Enhanced Alzheimer-Like Neuropathology in 3×Tg-AD Mice (2012) (53)
p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice (2014) (53)
BACE1 Elevation is Involved in Amyloid Plaque Development in the Triple Transgenic Model of Alzheimer’s Disease: Differential Aβ Antibody Labeling of Early-Onset Axon Terminal Pathology (2012) (52)
Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model (2006) (52)
Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer’s disease (2016) (51)
Olfactory memory is impaired in a triple transgenic model of Alzheimer disease (2011) (50)
Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease (2018) (50)
Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications. (2012) (50)
The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier) (2013) (49)
Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways (2017) (48)
AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer's Disease (2015) (48)
Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal function (2012) (46)
The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an in Vitro Model of Alzheimer Disease (2011) (44)
APP Knockout Mice Experience Acute Mortality as the Result of Ischemia (2012) (44)
Transgenic expression of B‐APP in fast‐twitch skeletal muscle leads to calcium dyshomeostasis and IBM‐like pathology (2006) (42)
Localization of cholesterol, amyloid and glia in Alzheimer’s disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging (2012) (42)
Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD (2017) (41)
Soluble Aβ promotes wild-type tau pathology in vivo (2012) (40)
Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer's disease. (2014) (40)
Rarity of the Alzheimer disease-protective APP A673T variant in the United States. (2015) (39)
Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology. (2009) (38)
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice (2012) (38)
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. (2014) (38)
Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. (2004) (36)
The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice. (2013) (36)
Injury induces presenilin-1 gene expression in mouse brain. (1996) (35)
Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice (2018) (35)
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia (2011) (35)
Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice. (2013) (34)
Profile for Amyloid-β and Tau Expression in Primary Cortical Cultures from 3xTg-AD Mice (2010) (34)
Sulforaphane Upregulates the Heat Shock Protein Co‐Chaperone CHIP and Clears Amyloid‐&bgr; and Tau in a Mouse Model of Alzheimer's Disease (2018) (34)
Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain (2014) (33)
Amyloid beta-peptide: the inside story. (2004) (33)
Genetic Knockdown of Brain-Derived Neurotrophic Factor in 3xTg-AD Mice Does Not Alter Aβ or Tau Pathology (2012) (33)
ST101 induces a novel 17kDa APP cleavage that precludes Aβ generation in vivo (2011) (32)
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology (2021) (32)
Treatment of Alzheimer's Disease with Anti-Homocysteic Acid Antibody in 3xTg-AD Male Mice (2010) (31)
Sortilin is required for toxic action of Aβ oligomers (AβOs): extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways. (2012) (31)
Genetically Altering Aβ Distribution from the Brain to the Vasculature Ameliorates Tau Pathology (2009) (31)
Optical imaging in an Alzheimer’s mouse model reveals amyloid-β-dependent vascular impairment (2014) (30)
Preclinical success against Alzheimer's disease with an old drug. (2012) (30)
Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Aβ(1-42) and tau. (2012) (29)
Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model (2015) (29)
Presenilin-1 Immunoreactivity Is Localized Intracellularly in Alzheimer's Disease Brain, but Not Detected in Amyloid Plaques (1997) (28)
miR‐181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease (2020) (28)
Deglycosylated anti‐amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration (2007) (26)
Elucidating the triggers, progression, and effects of Alzheimer's disease. (2012) (26)
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (26)
Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer’s Disease (2018) (23)
Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease (2018) (23)
Inhaled Anesthetic Potency in Aged Alzheimer Mice (2010) (23)
In vivo optical signatures of neuronal death in a mouse model of Alzheimer's disease (2013) (21)
Amyloid deposits show complexity and intimate spatial relationship with dendrosomatic plasma membranes: an electron microscopic 3D reconstruction analysis in 3xTg-AD mice and aged canines. (2009) (21)
Immunization with Amyloid-β Attenuates Inclusion Body Myositis-Like Myopathology and Motor Impairment in a Transgenic Mouse Model (2009) (21)
Transgenic Models of Alzheimer’s Disease (2001) (20)
Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer’s disease (2016) (19)
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling (2019) (19)
Early increases in soluble amyloid-β levels coincide with cholinergic degeneration in 3xTg-AD mice. (2012) (18)
Broad-based nutritional supplementation in 3xTg mice corrects mitochondrial function and indicates sex-specificity in response to Alzheimer's disease intervention. (2012) (18)
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition (2014) (18)
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer’s Disease (2021) (17)
Herpes Simplex Virus Infections and Alzheimer’s Disease (1998) (16)
Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models (2019) (16)
Past to Future: What Animal Models Have Taught Us About Alzheimer's Disease. (2018) (15)
Neural HO-1/sterol interactions in vivo: Implications for Alzheimer’s disease (2014) (15)
Experience-dependent regulation of vesicular zinc in male and female 3xTg-AD mice (2010) (15)
Amyloid-β expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum (2009) (15)
Pathways linking A β and tau pathologies (2010) (14)
MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis (2021) (13)
The Collagen Chaperone HSP47 Is a New Interactor of APP that Affects the Levels of Extracellular Beta-Amyloid Peptides (2011) (12)
Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus (2019) (11)
Proflavine derivatives as fluorescent imaging agents of amyloid deposits. (2011) (10)
AF 710 B , a Novel M 1 / σ 1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer ’ s Disease (2015) (8)
Hippocampal Adaptive Response Following Extensive Neuronal Loss in an Inducible Transgenic Mouse Model (2014) (8)
Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer’s disease mouse model (2021) (8)
The 3xTg-AD Mouse Model: Reproducing and Modulating Plaque and Tangle Pathology (2011) (8)
Animal Models of Alzheimer's Disease (2011) (7)
Combination of memantine and donepezil reverses cognitive deficits in transgenic mice with both amyloid-beta plaques and neurofibrillary tangles (2009) (7)
Repeated Physical Training and Environmental Enrichment Induce Neurogenesis and Synaptogenesis Following Neuronal Injury in an Inducible Mouse Model (2011) (6)
Treatment of Alzheimer's Disease with Anti-Homocysteic acid Antibody (2008) (6)
Antipodal Effects of p25 on Synaptic Plasticity, Learning, and Memory—Too Much of a Good Thing Is Bad (2005) (6)
COB231 targets amyloid plaques in post‐mortem human brain tissue and in an Alzheimer mouse model (2015) (6)
The Alzheimer??s beta-amyloid peptide induces neurodegeneration and apoptotic cell death in transgenic mice: 11.4 (1995) (6)
Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches (2021) (6)
Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tangles (2021) (6)
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90 (2022) (4)
Author Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation (2017) (3)
An array of genes implicated in Alzheimer's disease (2006) (3)
P1-451 M1 receptors play a central role in modulating AD-like pathology in transgenic mice (2006) (3)
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in Alzheimer mice (2010) (3)
O4-02-08: Chronic treatment with C5a antagonist decreases pathology in two mouse models of Alzheimer's disease (2008) (2)
M1 MUSCARINIC AGONISTS AND A MULTIPOTENT ACTIVATOR OF SIGMA1/M1 MUSCARINIC RECEPTORS: FUTURE THERAPEUTICS OF ALZHEIMER'S DISEASE (2014) (2)
39th Annual European Brain and Behaviour Society Abstracts (2007) (2)
39th Annual European Brain and Behaviour Society Abstracts (2007) (2)
39th Annual European Brain and Behaviour Society Abstracts (2007) (2)
Chapter 1:The Contribution of Transgenic Models to the Understanding of Alzheimer's Disease Progression and Therapeutic Development (2011) (2)
Amyloid plaques are formed in association with specific plasma membrane domains: An EM-immunogold 3-D-reconstruction study (2009) (2)
MODEL-AD: LATE-ONSET ALZHEIMER’S DISEASE MODELS (2018) (2)
B6 deficient feeding or homocysteic acid induces the earlier Alzheimer’s pathological change in normal C57BL male mice (2009) (2)
B 6 deficient feeding or homocysteic acid induces the earlier Alzheimer ’ s pathological change in normal C 57 BL male mice (2009) (2)
Cholesterol accumulates in the vicinity of amyloid-beta deposits in brain tissue (2011) (1)
A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques (2022) (1)
Voluntary exercise ameliorates both cognitive and noncognitive symptoms in the 3xTgAD mouse (2009) (1)
Roles in Alzheimer Disease Apolipoprotein E and Apolipoprotein E Receptors : Normal Biology and Subject Collection The Biology of Alzheimer Disease Animal Models of Alzheimer Disease (2012) (1)
Author Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation (2021) (1)
Amyloid plaques and neurofibrillary tangles in a triple transgenic model: qualitative similarities with human Alzheimer’s neuropathology (2005) (1)
Marking the Centennial of Alzheimers First Report of the Disease with a Perspective of Ongoing Research and Future Challenge (2006) (1)
O1-04-08 Antibody-mediated clearance of beta-amyloid reverses early TAU aggregates, but not late, hyperphosphorylated TAU (2004) (1)
β-Amyloid-Induced Neuronal Cell Death in Transgenic Mice and Alzheimer’s Disease (1997) (1)
Restoration of memory in mouse models of Alzheimer's disease and neuronal loss: A new paradigm using human neural stem cell therapy (2012) (1)
HAβ-KI: A KNOCK-IN MOUSE MODEL FOR SPORADIC ALZHEIMER’S DISEASE (2018) (1)
O1-06-04 Reduction of both soluble Aβ and tau, but not soluble Aβ alone, ameliorates cognitive decline in transgenic mice with plaques and tangles (2006) (1)
Human neural stem cell transplantation results in memory improvement in a 3xTg Alzheimer's disease model mice (2012) (1)
P38 AGE-DEPENDENT PHENOTYPIC CHARACTERISTICS OF A TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER??S DISEASE: EMOTION, ATTENTION AND COGNITION. (2006) (1)
Modeling neuropsychiatric symptoms of Alzheimer's disease in 3xTgAD mice: Neophobia, anxiety and aggressiveness at advanced stages of the disease (2010) (1)
Reductions in Aβ-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation (2014) (1)
MODEL-AD: CHARACTERIZATION OF FAMILIAL AD MODELS (5XFAD, APP/PS1, HTAU, 3XTG-AD) (2018) (1)
A unique target for a comprehensive therapy of Alzheimer’s disease: concomitant activation of SIGMA1/M1 muscarinic receptors (2016) (1)
Fluorometric Measurement of the Interaction between Chrysaora quinquecirrha (Sea Nettle) Toxin and Rat Liver Inner Mitochondrial Membranes (1984) (1)
Decrease of the antioxidant defenses in 3xTg-AD triple-transgenic adult mice for Alzheimer's disease (2009) (1)
Endogenous tau contributes to Alzheimer's-like tau pathology in 3xTg mice (2012) (1)
Axonal transport hypothesis moves on to implicate presenilin: Alzheimer research forum live discussion. (2004) (1)
P4-165: 3xTg-AD mouse neurons show early oxidized redox state (2008) (1)
TYPE 2 DIABETES MELLITUS INDUCES TAU-INDEPENDENT COGNITIVE AND SYNAPTIC DEFICITS IN A MOUSE MODEL (2019) (1)
Microglia mediated and fractalkine receptor dependent neuron loss in a mouse model of Alzheimer's disease (2009) (1)
Reductions in LPS- and Alzheimer's disease neuropathology-induced CNS inflammation with selective colony stimulating factor-1 receptor kinase inhibitors (2010) (1)
The Advantages of FTD Drug Development ( Part 2 of FTD : The Next Therapeutic Frontier ) (2013) (1)
Development of human ES cell lines as a model system for Alzheimer disease drug discovery (2019) (0)
IMPACT OF SYNAPTIC REGULATORS’ LOSS ON ALZHEIMER’S DISEASE (2018) (0)
Editorial Board and Contents (2017) (0)
Translating discoveries from mouse models to the clinic: Successes and challenges (2010) (0)
Long-term in vivo imaging identifies multiple events that trigger dendritic spine loss in 3xTg-AD mice (2009) (0)
Key Te rms Investigation of Transplanted Neural Stem Cells : The Extent of their Abil i ty to Improve Cognitive Deficit in Response to an Induced Lesion (2009) (0)
Contents Vol. 27, 2011 (2011) (0)
Deletion of MyD88 in astrocytes prevents β‐amyloid‐induced neuropathology in mice (2022) (0)
Amyloid propagation in a sporadic model of Alzheimer's disease (2020) (0)
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice (2012) (0)
Impact of genetic knockdown of brain-derived neurotrophic factor in 3xTg Alzheimer's mice (2012) (0)
An investigation of behavioral effects of Huprine X, a new potent anticholinesterasic, compared with Huperzine-A in 3xTgAD mice (2009) (0)
Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice (2018) (0)
DETERMINANTS OF MATERNAL AND INFANTICIDAL BEHAVIOR IN FEMALE MOUSE F1 HYBRIDS (2007) (0)
Mifepristone alters APP processing to preclude Aβ and also reduces tau pathology (2013) (0)
Transplanting Stem Cells into the Brain (2012) (0)
S5-03-04 Previous water-maze spatial training attenuates early, but not late, progressive memory loss in 3xTg-AD mice (2006) (0)
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease (2018) (0)
Stem Cell Therapy for Alzheimer's Disease (2015) (0)
248. Revealing the Role(s) of TNF-alpha in Early Alzheimer's Disease Via rAAV-Mediated Hippocampal Gene Transfer in a Triple Transgenic Mouse Model* (2006) (0)
Regeneration of the 3xTgAD brain by stem cell transplants (2010) (0)
Everything you've ever wanted to know about memory loss, dementia, current and future research, and more. Bring your Questions! (2010) (0)
O2-02-06: Blocking Aβ42 accumulation delays the onset and progression of Tau pathology and cognitive decline via CHIP: A mechanistic link between Aβ and Tau pathology (2008) (0)
Friday, March 16, 2007. pp. 97–134 (2007) (0)
P1-206 Capacitative and non-capacitative Ca2+ entry modulate Aβ levels (2004) (0)
P1-252 Androgens regulate development of neuropathology in a mouse model of Alzheimer’s disease (2006) (0)
NPT001: A candidate therapeutic for clearance of β-amyloid and tau aggregates in Alzheimer's disease (2011) (0)
Title Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer ' s disease and neuronal loss Permalink (2016) (0)
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2020) (0)
Spatial coding defects of hippocampal neural ensemble calcium activities in the 3xTg-AD Alzheimer’s disease mouse model (2021) (0)
The Clu‐rs2279590_h2kb variant increases axonal and neuritic damage in 5xFAD mice (2022) (0)
BlockingA 42 AccumulationDelaystheOnsetand ProgressionofTauPathologyviatheCTerminusofHeat ShockProtein70-InteractingProtein:AMechanisticLink betweenAandTauPathology (2008) (0)
Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer’s disease (2012) (0)
A novel multipotent sigma 1/M1 muscarinic activator for a comprehensive therapeutic strategy in Alzheimer's disease (2014) (0)
P3-005 PESTICIDE EXPOSURE INDUCES COGNITIVE ABNORMALITIES AND TAU HYPERPHOSPHORYLATION IN MALE RATS (2012) (0)
P.5.b.005 Combination of memantine and donepezil reverses cognitive deficits in transgenic mice with Alzheimer-type pathology (2009) (0)
Corrigendum to “Repeated cognitive stimulation alleviates memory impairments in an Alzheimer’s disease mouse model” [Brain Res. Bull. 117 (2015) 10–15] (2015) (0)
BrightFocus Alzheimer’s Fast Track 2019 (2019) (0)
Faculty Opinions recommendation of TFEB links autophagy to lysosomal biogenesis. (2011) (0)
Disease modifying effects of mifepristone (RU-486) in the 3xTg-AD mouse model of Alzheimer's disease (2010) (0)
PL-01-01: Mouse models of Alzheimer's disease (2008) (0)
Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models (2014) (0)
Using neural stem cells to promote plasticity and improve cognition in transgenic AD mice (2010) (0)
A Dual-Function “TRE-Lox” System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D (2023) (0)
S4-04-02 M1 muscarinic agonists as a comprehensive therapy in Alzheimer’s disease (2006) (0)
HUMAN WILD TYPE Aβ KNOCK-IN MICE AS A BASIS TO STUDY SPORADIC ALZHEIMER’S DISEASE (2019) (0)
APPKI-HaβWT: A NOVEL TRANSGENIC MOUSE TO MODEL SPORADIC ALZHEIMER’S DISEASE (2017) (0)
Temporal profile for amyloid precursor protein, amyloid-β and tau expression in primary cultures from 3xTg-AD mice (2009) (0)
P-188 Memantine lowers amyloid beta levels in neuronal cells and transgenic mouse models of Alzheimer’s disease (2007) (0)
P2-071 Ion channel properties of neurons from APP/PS1/TAU triple mutant mice (2004) (0)
Characterization of the behavioural dose-response of NMDA in 3xTg-AD mice at different stages of the disease and its modulation by early-life stimulation (2010) (0)
Plasma Signatures of Lipid and Cellular Energy Metabolism in the 5xFAD Mouse (2022) (0)
Live discussion: how the other half lives - or the what, how, and where, of the AbetaPP intracellular domain. (2004) (0)
Intraneuronal Aβ accumulation-more evidence, less controversy? Alzheimer research forum live discussion (2004) (0)
Development of new mouse strains containing alleles of loci associated with higher risk of late‐onset Alzheimer’s disease (LOAD) (2021) (0)
Impact of A β and Tau on Cognition in Mouse Models of Alzheimer’s Disease (2009) (0)
BACE1 Elevation is Involved in Amyloid Plaque Development in the Triple Transgenic Model of Alzheimer’s Disease: Differential Aβ Antibody Labeling of Early-Onset Axon Terminal Pathology (2011) (0)
Accumulation of periodic‐acid Schiff granules is increased in the presence of humanized amyloid beta (2021) (0)
Improving Memory with Stem Cell Transplantation (2009) (0)
Early window of mortality risk on 3xTgAD mice treated with an antipsychotic drug at advanced stages of the disease (2009) (0)
Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer’s Disease (2019) (0)
Late‐onset AD risk mutation PICALMH458R prevents plaque generation in 5xFAD mice (2022) (0)
Intraneuronal Aβ and Alzheimer’s Disease (2008) (0)
BrightFocus Alzheimer’s Fast Track 2019 (2019) (0)
P-191 Dietary DHA ameliorates amyloid-β and tau pathology via a mechanism involving presenilin 1 levels (2007) (0)
Restoration of memory in Alzheimer ’ s disease : a new paradigm using neural stem cell therapy (2019) (0)
Faculty Opinions recommendation of Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. (2011) (0)
Effects of Interleukin-6 trans-signalling in a mouse model of Alzheimer's disease and high fat diet-induced obesity (2019) (0)
The effect of pH on the N/NS protein complex and its subsequent effect on vesicular stomatitis virus genomic RNA replication in vitro (1988) (0)
SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer’s Disease (2021) (0)
Social memory impairment in a triple-transgenic mouse model of Alzheimer’s disease is accompanied by monoaminergic alterations (2009) (0)
Amyloid propagation in a sporadic model of Alzheimer disease (2021) (0)
Blocking interleukin-1 function attenuates Alzheimer's pathology via reducing anti-inflammatory responses in a transgenic mouse model (2010) (0)
Gender-dependent responses to a short treadmill training in the triple-transgenic 3xTg-AD mice (2010) (0)
ABCA7*V1599M variant in 5xFAD mice mediates differences in amyloid‐beta pathology and reactive gliosis (2022) (0)
Neural Stem cell transplants (2011) (0)
P1-124 Modeling neuropsychiatric symptoms of Alzheimer’s dementia in 3xTgAD mice (2006) (0)
Assessing the Clinical Meaningfulness of the Alzheimer’s Disease Composite Score (ADCOMS) Tool (2022) (0)
P1-081: Memantine reduces amyloid and Tau pathologies in a triple-transgenic mouse model of Alzheimer's disease (2008) (0)
THE DYSREGULATION OF TOM1 IN ALZHEIMER’S DISEASE (2018) (0)
BIN1 K358R variant in 5xFAD mice ameliorates AB pathology and microgliosis (2022) (0)
Role of M1 receptors in Alzheimer's disease (2010) (0)
Transgenic Models of Alzheimer ' s Disease 51 51 (2018) (0)
P4-371 In vivo evidence linking Aβ and TAU (2004) (0)
Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer’s disease (2020) (0)
P4-251: Changes in Akt and IGF-1 receptor signaling relate to developing Abeta and tangle pathology in the triple transgenic model of Alzheimer's disease (2008) (0)
Neural Stem Cells as a Developmental Candidate to Treat Alzheimer Disease (2018) (0)
Highly cited clinical and epidemiological papers on Alzheimer disease published in 2004 (2006) (0)
Treatment with a serotonin 5-HT4-receptor agonist ameliorates cognitive deficits and amyloid pathology in the 3xTg-AD model of Alzheimer's disease (2012) (0)
P2-343: Peripherally overexpessed neprilysin in muscle reduces brain amyloid in a transgenic mouse model of AD (2008) (0)
P1-125 Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult and aged Alzheimer disease mice (2006) (0)
Health Effects of Occupational Exposures of Welders: Multicenter Study Using a Uniform Core Protocol (1989) (0)
Ultrastructural investigation of tau-dependent dendropathy in a triple transgenic mouse model of Alzheimer's disease (2009) (0)
P2-073 Assessing cognitive impairments in the 3XTG-AD mice: correlations with plaque and tangle pathology (2004) (0)
Relevance of Transgenic Mouse Models to Human (2009) (0)
P4-385 Alzheimer's epitope vaccine based on the dominant B cell epitope of Aβ and padre, a foreign T cell epitope (2004) (0)
Intraneuronal Ab and Alzheimer's Disease (2008) (0)
b -KI: A KNOCK-IN MOUSE MODEL FOR SPORADIC ALZHEIMER’S DISEASE (2018) (0)
Title SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production Permalink (0)
Trem2 R47H NSS; 5xFAD mice display age/disease progression‐dependent changes in plaques and plaque‐associated microglia, and increased plasma neurofilament light chain (2022) (0)
Hyperactivation of PI3-kinase-Akt signaling: a central molecular link between early Amuloid beta and tau pathogenesis in Alzheimer's disease (2011) (0)
O2-05-01 Peripheral expression of neprilysin decreases amyloid deposition in hAPP mice (2006) (0)
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (0)
Functional in vitro assembly of the nucleocapsid of a defective interfering particle of vesicular stomatitis virus (1988) (0)
The following abstracts were presented as posters at the 2011 NEI Global Psychopharmacology Congress (2012) (0)
Presenilins are necessary for efficient autophagic and lysosomal functioning through a gamma-secretase-independent mechanism (2010) (0)
Effect of immunization with the oligomeric form of the Aβ peptide: Reduction of senile plaque area, decreased complement C3 deposition and synthesis, and decline in behavioral function in a murine model of Alzheimer's disease (2007) (0)
O-GlcNAc regulation of hippocampal synaptic plasticity in wild type and 3xTg-AD mice (2009) (0)
Alzheimer ' s disease Chronic nicotine administration exacerbates tau pathology in a transgenic model of (2005) (0)
P2-119 Alterations of intracellular CA2+ homeostasis in a triple transgenic model (PS1M146V, APPSWE, TAUP301L) of Alzheimer's disease (2004) (0)