Frank Woods
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Pharmacologist
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Frank Woods medical Degrees
Medical
#2925
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Pharmacology
#449
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#504
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Medical
Frank Woods 's Degrees
- PhD Pharmacology University of California, San Francisco
Why Is Frank Woods Influential?
(Suggest an Edit or Addition)According to Wikipedia, Professor Hubert Frank Woods , known as Frank, was a British pharmacologist. He was appointed professor of pharmacology and therapeutics at the University of Sheffield in 1976. In 1989 he became Sir George Franklin professor of medicine and was made the University's director of the division of clinical sciences . He was dean of the faculty of medicine there from 1988 to 1998.
Frank Woods 's Published Works
Published Works
- Metformin kinetics in healthy subjects and in patients with diabetes mellitus. (1981) (461)
- The cause of hepatic accumulation of fructose 1-phosphate on fructose loading. (1970) (347)
- Oxidation phenotype--a major determinant of metoprolol metabolism and response. (1982) (288)
- The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6). (1994) (249)
- Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers (1983) (224)
- Clinical and biochemical aspects of lactic acidosis (1976) (195)
- Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes. (1988) (168)
- AGE-DEPENDENT SENSITIVITY TO SALICYLATE (1975) (164)
- Metoprolol metabolism and debrisoquine oxidation polymorphism--population and family studies. (1985) (161)
- Dangers of intravenous fructose. (1972) (139)
- LACTIC ACIDOSIS AND HYPERLACTATÆMIA (1974) (118)
- Lactate production in the perfused rat liver. (1971) (115)
- Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease. (1998) (104)
- Human platelet monoamine oxidase activity in iron-deficiency anaemia. (1975) (88)
- Polymorphic drug oxidation: pharmacokinetic basis and comparison of experimental indices. (1986) (84)
- The Polymorphic Oxidation of β-Adrenoceptor Antagonists (1986) (81)
- Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol. (1986) (75)
- Metoprolol and debrisoquin metabolism in nigerians: Lack of evidence for polymorphic oxidation (1986) (75)
- Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics. (1985) (74)
- The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol. (1984) (68)
- Comparison of the kinetics and utilisation of D(-)-and L(+)-sodium lactate in normal man. (1983) (67)
- Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine. (1975) (64)
- Altered plasma drug binding in cancer: Role of α1‐acid glycoprotein and albumin (1982) (63)
- Metabolism of an oral tryptophan load. I: Effects of dose and pretreatment with tryptophan. (1980) (59)
- Lactic Acidosis Revisited (1983) (57)
- A model of L(+)-lactate metabolism in normal man. (1982) (53)
- Xylitol metabolism in the isolated perfused rat liver. (1973) (52)
- Lignocaine and indocyanine green kinetics in patients following myocardial infarction. (1980) (49)
- Inhibition of oxidative drug metabolism by beta-adrenoceptor antagonists in related to their lipid solubility. (1981) (49)
- The Effect of Metformin on Glycaemic Control, Intermediary Metabolism and Blood Pressure in Non‐insulin‐dependent Diabetes Mellitus (1987) (46)
- Clinical Manifestations of Carcinoid Disease (1996) (46)
- Letter: Lactic acidosis and hyperlactataemia. (1974) (45)
- Determination of metformin in biological samples. (1978) (45)
- The effect of glycerol and dihydroxyacetone on hepatic adenine nucleotides. (1973) (45)
- A modified prognostic index based upon nutritional measurements. (1982) (44)
- Evidence for a dissociation in the control of sparteine, debrisoquine and metoprolol metabolism in Nigerians. (1992) (44)
- Beeturia and the biological fate of beetroot pigments. (1993) (41)
- Irreversible binding and metabolism of propranolol by human liver microsomes--relationship to polymorphic oxidation. (1987) (40)
- The impairment of lignocaine clearance by propranolol--major contribution from enzyme inhibition. (1985) (40)
- Catalytic activities of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6) expressed in yeast. (1992) (39)
- Factors influencing effect of hydrocortisone on rat brain tryptophan metabolism (1975) (39)
- HEPARIN-INDUCED DECREASE IN CIRCULATING ANTITHROMBIN III (1978) (38)
- Effects of beta-adrenoceptor antagonists on the pharmacokinetics of lignocaine. (1984) (38)
- Activation of liver pyruvate kinase by fructose‐1‐phosphate (1970) (37)
- The polymorphic oxidation of beta-adrenoceptor antagonists. Clinical pharmacokinetic considerations. (1986) (36)
- Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism--histograms and probit plots. (1989) (34)
- Quantitative aspects of L(+)-lactate metabolism in human beings. (2008) (34)
- Some properties of human platelet monoamine oxidase in iron-deficiency anaemia. (1976) (33)
- Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism--hypothesis testing. (1989) (32)
- Abdominal carcinoid tumours in Sheffield. (1990) (30)
- Letter: Age-dependent sensitivity to salicylate. (1975) (30)
- Oral methionine loading as a cause of acute serum folate deficiency: its relevance to parenteral nutrition. (1978) (29)
- Backtracking booze with Bayes--the retrospective interpretation of blood alcohol data. (1991) (28)
- The influence of tissue environment on the rates of metabolic processes and the properties of enzymes. (1975) (28)
- Propranolol oxidation by human liver microsomes--the use of cumene hydroperoxide to probe isoenzyme specificity and regio- and stereoselectivity. (1990) (27)
- TRYPTOPHAN METABOLISM IN THE ISOLATED PERFUSED LIVER OF THE RAT: EFFECTS OF TRYPTOPHAN CONCENTRATION, HYDROCORTISONE AND ALLOPURINOL ON TRYPTOPHAN PYRROLASE ACTIVITY AND KYNURENINE FORMATION (1976) (26)
- The expression of human cytochrome P450IA1 in the yeast Saccharomyces cerevisiae. (1991) (23)
- INHIBITION BY SALICYLATE OF GLUCONEOGENESIS IN THE ISOLATED PERFUSED RAT LIVER (1974) (22)
- Metoprolol oxidation by rat liver microsomes. Inhibition by debrisoquine and other drugs. (1986) (21)
- Physicochemical properties, development, and regulation of central and peripheral monoamine oxidase activity. (1974) (21)
- Monoamine metabolism and platelet function in iron-deficiency anaemia. (1976) (21)
- Lack of effect of atenolol on antipyrine clearance. (1982) (20)
- Altered plasma drug binding in cancer: role of alpha 1-acid glycoprotein and albumin. (1982) (20)
- Metabolism of an oral tryptophan load by women and evidence against the induction of tryptophan pyrrolase by oral contraceptives. (1978) (20)
- Polymorphic metabolism of metoprolol: Clinical studies (2004) (19)
- INHIBITION OF 5‐HYDROXYTRYPTAMINE‐INDUCED HUMAN BLOOD PLATELET AGGREGATION BY CHLORPROMAZINE AND ITS METABOLITES (1975) (18)
- Polymorphic metabolism of beta-adrenoceptor antagonists. (1984) (17)
- Lacticacidosis, ketoacidosis, and hyperalaninaemia in a phenformintreated diabetic patient. (1974) (17)
- Stereoselective metabolism of metoprolol in Caucasians and Nigerians--relationship to debrisoquine oxidation phenotype. (1989) (15)
- Muscle protein breakdown in thyrotoxicosis assessed by urinary 3-methylhistidine excretion. (1981) (15)
- Hepatic accumulation of metabolites after fructose loading. (2009) (15)
- Timolol metabolism and debrisoquine oxidation polymorphism: a population study. (1989) (15)
- The effect of beta-adrenoceptor antagonists on the pharmacokinetics and pharmacodynamics of warfarin after a single dose. (1984) (14)
- Assessment of an in situ rat intestine preparation with perfused vascular bed for studying the absorption and first-pass metabolism of drugs. (1985) (14)
- Octreotide therapy in carcinoid disease (1996) (14)
- Inborn ‘Errors’ of Drug Metabolism Pharmacokinetic and Clinical Implications (1990) (13)
- Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function. (2009) (13)
- Assessment of the mouse as an experimental model for studying polymorphic oxidation of the sparteine/debrisoquine type. (1991) (13)
- The role of altered lactate kinetics in the pathogenesis of type B lactic acidosis. (1982) (13)
- Utilization of L(+) lactate in patients with liver disease. (1982) (12)
- Penbutolol and propranolol: a comparison of their effects on antipyrine clearance in man. (1985) (12)
- Inhibition of lignocaine metabolism by beta-adrenoceptor antagonists in rat and human liver microsomes. (1989) (12)
- Resuspension of platelets: enhanced 5-hydroxytryptamine-induced aggregation in chlorpromazine treated patients due to changes in platelet properties. (1975) (11)
- Phagocytic function in the isolated perfused rat liver. An experimental model. (1985) (11)
- Effect of steroids on the cytochrome P4502D6-catalysed metabolism of metoprolol. (1991) (11)
- Metabolism of an oral tryptophan load. II: Effect of pretreatment with the putative tryptophan pyrrolase inhibitors nicotinamide or allopurinol. (1980) (10)
- The oral clearance and beta-adrenoceptor antagonist activity of propranolol after single dose are not related to debrisoquine oxidation phenotype. (1984) (10)
- Carcinoid Tumours and the Carcinoid Syndrome (1989) (9)
- Some histological and metabolic properties of an isolated perfused rat brain preparation with special reference to monoamine metabolism (1976) (9)
- Persistent anemia associated with reduced serum vitamin B12 levels in patients undergoing regular hemodialysis therapy. (1979) (9)
- Small bowel carcinoid tumors (1985) (8)
- Histamine: an inhibitor of cytochrome P-450-catalysed drug metabolism. (1986) (8)
- Metformin and lactic acidosis. (1999) (8)
- Hyperlactataemia during intravenous feeding in childhood (1974) (7)
- The nutritional assessment of hospital patients - a critical review. (1981) (7)
- The Kinetics of Elimination of a Sodium l-Lactate Load in Man: The Effect of Liver Disease (1978) (7)
- The detection of polymorphic drug oxidation--some theoretical and practical aspects. (1986) (7)
- Histamine inhibition of mixed function oxidase activity in rat and human liver microsomes and in the isolated perfused rat liver. (1989) (6)
- Protecting the poor metaboliser—from Jack & Wilkins. Dr Lennard et al. reply as follows (1984) (6)
- Stereoselective 4-hydroxylation of debrisoquine in Nigerians. (1988) (6)
- Biochemical methods in nutritional assessment (1982) (6)
- Proceedings: Reduction of platelet monoamine oxidase activity in iron deficiency anaemia. (1974) (6)
- Muscle Protein Breakdown in Thyrotoxicosis Assessed by Urinary 3-Methylhistidine Excretion (1980) (5)
- Methods for the study of lung metabolism. (1980) (5)
- Lack of relationships between the debrisoquine (CYP2D6) and mephenytion (CYP2C19) oxidation polymorphisms and susceptibility to breast cancer (1996) (5)
- The effect of increasing phenylalanine concentration on phenylalanine metabolism in perfused rat liver. (1975) (5)
- The effect of beta-adrenoceptor antagonists on the pharmacokinetics and pharmacodynamics of warfarin. (1984) (5)
- Product-Inhibition of Hepatic Lignocaine Metabolism (1978) (4)
- Glucuronyl‐transferase activity in uraemic rats (1980) (4)
- Lactic acidosis and hyperlactataemia. (1974) (4)
- Time-dependent kinetics of lignocaine in the isolated perfused rat liver (1983) (4)
- Clinical and biochemical effects of parachlorophenylalanine in a patient with the carcinoid syndrome (1982) (4)
- Inhibition of Human Platelet Function Induced by Sulphinpyrazone (1979) (4)
- Therapeutic Audit on A General Medical Ward (1987) (4)
- An Isolated Perfused Rat Brain Preparation—Some Histological and Metabolic Features (1974) (3)
- The Addition of Micronutrients to Food (2001) (3)
- Interactions between food and drugs (1982) (3)
- Theimpairment oflignocaine clearance bypropranolol-major contribution fromenzymeinhibition (1985) (3)
- Metabolic pathways for carbohydrates in parenteral nutrition (1978) (3)
- Bicarbonate and cytoplasmic pH (1990) (3)
- Hepatic metabolism of pentites. (1975) (3)
- GEP Tumours: General Discussion (1990) (2)
- Polymorphic drugoxidation: pharmacokinetic basis and comparison ofexperimental indices (1986) (2)
- The isolated perfused rat brain preparation--a critical assessment. (1977) (2)
- Metabolic Consequences of the Short-Term Exposure of the Liver to Paracetamol (1978) (2)
- Can lignocaine kinetics be predicted? [proceedings]. (1978) (2)
- 5-Hydroxytryptamine synthesis in the isolated perfused rat brain. (1975) (2)
- Can lignocaine kinetics be predicted (1980) (2)
- Is total parenteral nutrition necessary after total cystectomy? — a pilot study (1984) (2)
- Assessing the risks to human health associated with exposure to dioxins (1995) (2)
- Metformin: absorption and disposition in healthy subjects and in diabetic patients [proceedings]. (1979) (2)
- Disturbances of acid–base homeostasis (2010) (2)
- A journal's progress. (1983) (1)
- 2587 – DOSE-, TIME- AND SEX-DEPENDENT METABOLISM OP LIGNOCAINE IN THE ISOLATED PERFUSED RAT LIVER (1978) (1)
- Pathogenic mechanisms of disorders in fructose metabolism (1980) (1)
- Proceedings: Tryptophan metabolism by the isolated perfused rat liver. (1975) (1)
- Perspectives in Gastroenterology: General Discussion (1990) (1)
- Proceedings: Physico-chemical properties, development, and regulation of central and peripheral monoamine oxidase activity. (1974) (1)
- Successful pregnancy soon after oral contraceptive-associated malignant hypertension (1980) (1)
- The Nutritional fate of the undernourished Surgical patient in convalescence (1980) (1)
- Lactic Acidosis Complicating Late-pregnancy-onset Diabetes (1969) (1)
- Disopyramide elimination in the isolated perfused rat liver. (1984) (1)
- O.92 Assessing the performance of prognostic nutritional indices (1983) (1)
- Monoamine metabolism in the isolated perfused rat brain. (1976) (1)
- A Comparison of the Utilization of d-and l+ Sodium Lactate in Normal man (1978) (1)
- Sweetness in the diabetic diet (1982) (1)
- Nephrotic syndrome in vesicoureteric reflux. (1976) (1)
- Inhibition of Drug Metabolism by β-Adrenoceptor Antagonists (1983) (1)
- Dialysis: A global perspective (1991) (1)
- The epidemiology of carcinoid tumours in the Trent Region (1989) (0)
- Timolol metabolism anddebrisoquine oxidation polymorphism: apopulation study (1989) (0)
- Therelationship between debrisoquine oxidation phenotype andthepharmacokinetics andpharmacodynamics of propranolol (1984) (0)
- METABOLISM OFAN ORAL TRYPTOPHANLOAD. I:EFFECTSOFDOSEAND PRETREATMENTWITHTRYPTOPHAN (1980) (0)
- Metabolic anormalities in patients prior to parenteral feeding. (1979) (0)
- EFFECT OF LABETALOL, AN a-AND ,8-ADRENOCEPTOR ANTAGONIST, ON GASTRIC ACID AND GASTRIN SECRETION IN MAN (2006) (0)
- Variability of plasma drug concentrations — A reply (2004) (0)
- Contents, Vol. 27, 1983 (1983) (0)
- Polymorphic metabolism of /8-adrenoceptor antagonists (2006) (0)
- Proceedings: An isolated perfused rat brain--some histological and metabolic features. (1974) (0)
- A Method for the Study of Kupffer Cell Function (1982) (0)
- Vitamins in medicine. Volume 2 (1982) (0)
- Impaired Metabolism of Metoprolol in Poor Hydroxylators of Debrisoquine (1983) (0)
- Metabolic Complications of Intravenous Feeding with Solutions Containing Fructose and Amino Acids (1975) (0)
- The experimental deign and analysis of in vivo studies of polymorphic drug oxidation (1990) (0)
- synthesis in the isolated perfused rat brain (2006) (0)
- Chairman’s Summary (1990) (0)
- Successful pregnancy soon after oral contraceptive-associated malignant hypertension. (1981) (0)
- Clinical andbiochemical effects ofparachlorophenylalanine inapatient with the carcinoid syndrome (1982) (0)
- SALBUTAMOL AND KETONURIA IN PREGNANCY CASE REPORT (1980) (0)
- The influence of human variability upon food safety legislation. (1996) (0)
- Effects of nutrition on drug metabolism and distribution. (1978) (0)
- Therapeutic pharmacology: Glenn D. Appelt and Jennifer M. Appelt Lea and Febiger, Philadelphia 1988. ISBN 0 8121 115 X, 503 pages (1989) (0)
- The metabolic complications of intravenous nutrition. (1976) (0)
- Clinical usage of amino acids (1983) (0)
- Phenylethylamine formation in perfused rat liver [proceedings]. (1976) (0)
- The Role of Liver Dysfunction in the Genesis of Lactic Acidosis1 (1979) (0)
- Oralmethionine loading asacauseofacute serumfolate deficiency: its relevance toparenteral nutrition (1978) (0)
- Subject Index, Vol. 27, 1983 (1983) (0)
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