Franklin Aigbirhio
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Nigerian-born British chemist
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Franklin Aigbirhiochemistry Degrees
Chemistry
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Organic Chemistry
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Chemistry
Franklin Aigbirhio's Degrees
- Bachelors Chemistry University of Lagos
- Masters Chemistry University of Oxford
Why Is Franklin Aigbirhio Influential?
(Suggest an Edit or Addition)According to Wikipedia, Franklin Imo Aigbirhio, is a Nigerian-born British chemist and academic specialising in biomedical imaging research. Since 2014 he has been the Professor of Molecular Imaging Chemistry at the University of Cambridge.
Franklin Aigbirhio's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement (2007) (1150)
- Diffusion limited oxygen delivery following head injury* (2004) (300)
- Incidence and Mechanisms of Cerebral Ischemia in Early Clinical Head Injury (2004) (228)
- Decision-making in mania: a PET study. (2001) (225)
- Dopamine Release in Dissociable Striatal Subregions Predicts the Different Effects of Oral Methylphenidate on Reversal Learning and Spatial Working Memory (2009) (223)
- Hyperventilation following head injury: Effect on ischemic burden and cerebral oxidative metabolism* (2007) (222)
- 18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy (2017) (184)
- Intrinsic Activated Microglia Map to the Peri-infarct Zone in the Subacute Phase of Ischemic Stroke (2006) (174)
- Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn's adenomas. (2012) (168)
- How Reliable Is Perfusion MR in Acute Stroke?: Validation and Determination of the Penumbra Threshold Against Quantitative PET (2008) (167)
- Assessment of Cerebrovascular Autoregulation in Head-Injured Patients: A Validation Study (2003) (167)
- Correlation between Cerebral Blood Flow, Substrate Delivery, and Metabolism in Head Injury: A Combined Microdialysis and Triple Oxygen Positron Emission Tomography Study (2002) (160)
- Reactions of cyclotron-produced [18F]fluoride with diaryliodonium salts—a novel single-step route to no-carrier-added [18]fluoroarenes (1995) (149)
- Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: Preliminary findings* (2008) (145)
- Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury. (2005) (144)
- Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury. (2014) (134)
- The pattern of amyloid accumulation in the brains of adults with Down syndrome (2016) (127)
- Functionalized bis(thiosemicarbazonato) complexes of zinc and copper: synthetic platforms toward site-specific radiopharmaceuticals. (2007) (125)
- Hypoxia and tissue destruction in pulmonary TB (2016) (117)
- Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury. (2016) (113)
- Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes. (2010) (106)
- Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method. (2002) (95)
- How affected is oxygen metabolism in DWI lesions? (2006) (93)
- A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) (93)
- In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings (2017) (92)
- Does the Acute Diffusion-Weighted Imaging Lesion Represent Penumbra as Well as Core? A Combined Quantitative PET/MRI Voxel-Based Study (2004) (92)
- Selective neuronal loss in rescued penumbra relates to initial hypoperfusion. (2008) (88)
- Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease (2019) (82)
- Does induced hypertension reduce cerebral ischaemia within the traumatized human brain? (2004) (81)
- Early microglial activation and peripheral inflammation in dementia with Lewy bodies (2018) (80)
- Cu(I)-catalyzed (11)C carboxylation of boronic acid esters: a rapid and convenient entry to (11)C-labeled carboxylic acids, esters, and amides. (2012) (77)
- Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury (2003) (74)
- Responses of Posttraumatic Pericontusional Cerebral Blood Flow and Blood Volume to an Increase in Cerebral Perfusion Pressure (2003) (74)
- Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes. (2008) (73)
- [18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia (2017) (72)
- Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging. (2007) (69)
- The Diffusion-Weighted Lesion in Acute Stroke: Heterogeneous Patterns of Flow/Metabolism Uncoupling as Assessed by Quantitative Positron Emission Tomography (2005) (68)
- Imaging of Brain Hypoxia in Permanent and Temporary Middle Cerebral Artery Occlusion in the Rat using 18F-Fluoromisonidazole and Positron Emission Tomography: A Pilot Study (2007) (66)
- Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility. (2011) (64)
- Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses (2017) (64)
- 18 FAV-1451 positron emission tomography in Alzheimer ’ s disease and progressive supranuclear palsy (2017) (64)
- A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups. (2011) (64)
- White Matter Perivascular Spaces on Magnetic Resonance Imaging: Marker of Cerebrovascular Amyloid Burden? (2015) (62)
- [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy (2018) (61)
- Neuroinflammatory and morphological changes in late-life depression: the NIMROD study (2016) (59)
- Imaging regional variation of cellular proliferation in gliomas using 3'-deoxy-3'-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study. (2009) (56)
- Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders (2012) (54)
- FDG–PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis (2009) (54)
- Orbitofrontal Dopamine Depletion Upregulates Caudate Dopamine and Alters Behavior via Changes in Reinforcement Sensitivity (2014) (52)
- Dissociable Rate-Dependent Effects of Oral Methylphenidate on Impulsivity and D2/3 Receptor Availability in the Striatum (2015) (52)
- Diagnostic Utility of Amyloid PET in Cerebral Amyloid Angiopathy-Related Symptomatic Intracerebral Hemorrhage (2014) (51)
- Fluorescent copper(II) bis(thiosemicarbazonates): synthesis, structures, electron paramagnetic resonance, radiolabeling, in vitro cytotoxicity and confocal fluorescence microscopy studies. (2010) (49)
- Baseline-Dependent Effects of Cocaine Pre-Exposure on Impulsivity and D2/3 Receptor Availability in the Rat Striatum: Possible Relevance to the Attention-Deficit Hyperactivity Syndrome (2013) (49)
- Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901 (2008) (49)
- Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum (2019) (47)
- In Vitro and In Vivo Evaluations of a Hydrophilic 64Cu-Bis(Thiosemicarbazonato)–Glucose Conjugate for Hypoxia Imaging (2008) (44)
- Early Derangements in Oxygen and Glucose Metabolism Following Head Injury: The Ischemic Penumbra and Pathophysiological Heterogeneity (2008) (43)
- Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: A multi-modality imaging study (2013) (41)
- Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans (2010) (39)
- Local Relationships Between Restricted Water Diffusion and Oxygen Consumption in the Ischemic Human Brain (2006) (38)
- Synaptic Loss in Primary Tauopathies Revealed by [11C]UCB‐J Positron Emission Tomography (2020) (37)
- Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures. (2012) (37)
- Vascular Imaging With 18F-Fluorodeoxyglucose Positron Emission Tomography Is Influenced by Hypoxia (2017) (36)
- Synthesis and Initial in Vivo Studies with [(11)C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3. (2015) (35)
- Probing small molecule binding to amyloid fibrils. (2011) (35)
- Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury (2019) (34)
- Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI. (2016) (34)
- Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia. (2016) (33)
- The Vascular Mean Transit Time: A Surrogate for the Penumbra Flow Threshold? (2011) (33)
- Ring-Methyl Activation in Pentamethylcyclopentadienyl Complexes. 5.1 Syntheses and Structures of Tetramethylfulvene Complexes of Ruthenium(II) (1996) (33)
- Predicting Infarction Within the Diffusion-Weighted Imaging Lesion: Does the Mean Transit Time Have Added Value? (2011) (32)
- Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man (2018) (32)
- Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study (2014) (31)
- Early-Phase 11C-PiB PET in Amyloid Angiopathy-Related Symptomatic Cerebral Hemorrhage: Potential Diagnostic Value? (2015) (31)
- Microembolism Versus Hemodynamic Impairment in Rosary-Like Deep Watershed Infarcts: A Combined Positron Emission Tomography and Transcranial Doppler Study (2011) (31)
- Some unusual organo-zinc and -mercury compounds. The crystal structures of the compounds [(HOMe2Si)(Me3Si)2C]2Zn, [(MeOMe2Si)(Me3Si)2C]2Zn, and [(MeOMe2Si)(Me3Si)2C]2Hg (1991) (29)
- A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation (2012) (29)
- Is neural activation within the rescued penumbra impeded by selective neuronal loss? (2013) (29)
- AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia (27)
- Reactions of Cyclotron-Produced (18F)Fluoride with Diaryliodonium Salts - A Novel Single-Step Route to No-Carrier-Added (18F) Fluoroarenes. (1996) (27)
- Microglial activation and blood–brain barrier permeability in cerebral small vessel disease (2021) (26)
- Targeted Molecular Imaging in Adrenal Disease—An Emerging Role for Metomidate PET-CT (2016) (26)
- Xenon difluoride exchanges fluoride under mild conditions: a simple preparation of [(18)F]xenon difluoride for PET and mechanistic studies. (2001) (25)
- Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of τ-pathology (2013) (25)
- Rapid preparation of [11C]flumazenil: captive solvent synthesis combined with purification by analytical sized columns (2007) (24)
- Neuroinflammation predicts disease progression in progressive supranuclear palsy (2020) (24)
- An Efficient Method for Enhancing the Reactivity and Flexibility of [18F]Fluoride Towards Nucleophilic Substitution Using Tetraethylammonium Bicarbonate (2014) (23)
- Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy (2020) (23)
- [ 11 C ] PK 11195 binding in Alzheimer disease and progressive supranuclear palsy (23)
- P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain (2013) (22)
- In vivo evidence for pre‐symptomatic neuroinflammation in a MAPT mutation carrier (2019) (22)
- In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease (2018) (22)
- Modelling human drug abuse and addiction with dedicated small animal positron emission tomography (2009) (21)
- Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury (2011) (21)
- T2*-Weighted MRI versus Oxygen Extraction Fraction PET in Acute Stroke (2009) (21)
- No carrier-added nucleophilic aromatic radiofluorination using solid phase supported arenediazonium sulfonates and 1-(aryldiazenyl)piperazines (2012) (21)
- Synthesis, in Vitro Evaluation, and Radiolabeling of Fluorinated Puromycin Analogues: Potential Candidates for PET Imaging of Protein Synthesis. (2016) (20)
- Syntheses of the first endothelin-A- and -B-selective radioligands for positron emission tomography. (2000) (20)
- Single-subject statistical mapping of acute brain hypoxia in the rat following middle cerebral artery occlusion: A microPET study (2011) (19)
- Validation and Quantification of [18F]Altanserin Binding in the Rat Brain Using Blood Input and Reference Tissue Modeling (2011) (19)
- S-[1-(2,3-diaminophenoxy)]-3′-(N-t-butylamino)propan-2′-ol-simplified asymmetric synthesis with CD and chiral HPLC analysis (1992) (18)
- Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates (2019) (18)
- Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo (2017) (17)
- Radiosynthesis of (R,S)‐[18F]GE387: A Potential PET Radiotracer for Imaging Translocator Protein 18 kDa (TSPO) with Low Binding Sensitivity to the Human Gene Polymorphism rs6971 (2019) (16)
- Synthesis and Evaluation of 18F-FE-PEO in Rodents: An 18F-Labeled Full Agonist for Opioid Receptor Imaging (2013) (16)
- Imaging of cerebral blood flow and metabolism in brain injury in the ICU. (2005) (16)
- Correlation of microglial activation with white matter changes in dementia with Lewy bodies (2019) (15)
- An automated method for regular productions of copper-64 for PET radiopharmaceuticals (2010) (15)
- Comparison of Lorazepam [7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] Occupancy of Rat Brain γ-Aminobutyric AcidA Receptors Measured Using in Vivo [3H]Flumazenil (8-Fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester) (2007) (15)
- Relationship between tau, neuroinflammation and atrophy in Alzheimer's disease: The NIMROD study (2021) (15)
- A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke. (2013) (15)
- Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease (2019) (15)
- Synaptic density in carriers of C9orf72 mutations: a [11C]UCB‐J PET study (2021) (15)
- Disposition of inhaled 1,1,1,2-tetrafluoroethane (HFA134A) in healthy subjects and in patients with chronic airflow limitation. Measurement by 18F-labeling and whole-body gamma-counting. (1995) (14)
- Automated radiosynthesis of no-carrier-added [S-fluoromethyl- 18F]fluticasone propionate as a radiotracer for lung deposition studies with PET (1997) (14)
- Efficient and selective labelling of the CFC alternative, 1,1,1,2-tetrafluoroethane, with 18F in the 1-position (1993) (13)
- 18F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy (2019) (13)
- Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report (2019) (13)
- Synthesis, crystal structure and reactions of the dimeric organolithium compound [{[(MeO)Me2Si]3CLi}2] (1992) (13)
- Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis. (2017) (12)
- Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease (2022) (12)
- Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study (2021) (12)
- Flixotide™‐pressurized metered‐dose inhalers loaded with [18F]fluticasone propionate particles for drug deposition studies in humans with PET–formulation and analysis (2004) (12)
- In vivo PET imaging of neuroinflammation in familial frontotemporal dementia (2020) (12)
- Efficient regioselective labelling of the CFC alternative 1,1,1,2-tetrafluoroethane (HFC-134a) with fluorine-18 (1995) (12)
- Gray matter changes related to microglial activation in Alzheimer's disease (2020) (11)
- Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography (2020) (10)
- Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics (2018) (10)
- 18 F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy (2017) (9)
- 11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies (2020) (9)
- In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies (2020) (9)
- DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits (2020) (9)
- Preclinical evaluation of (S)-[18F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971 (2021) (8)
- Abstract 14673: Imaging of Hypoxia and Inflammation in Carotid Atherosclerosis With 18F-Fluoromisonidazole and 18F-Fluorodeoxyglucose Positron Emission Tomography (2013) (8)
- Automated radiosynthesis of [11C]UCB‐J for imaging synaptic density by positron emission tomography (2020) (8)
- Para-chloro-2-[18F]fluoroethyl-etomidate: A promising new PET radiotracer for adrenocortical imaging (2021) (8)
- Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury (2021) (8)
- Quantification of receptor–ligand binding potential in sub-striatal domains using probabilistic and template regions of interest (2011) (8)
- Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain (2021) (8)
- Brain hypoxia mapping in acute stroke: Back-to-back T2′ MR versus 18F-fluoromisonidazole PET in rodents (2017) (8)
- Radiosynthesis of 11-[(18) F]fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer. (2013) (7)
- Delineating the topography of amyloid-associated cortical atrophy in Down syndrome (2019) (7)
- Novel use of an isotope separator to determine the position of fluorine-18 in labelled 1,1,1,2-tetrafluoroethanes (1994) (7)
- Detection limit of 89Zr-labeled T cells for cellular tracking: an in vitro imaging approach using clinical PET/CT and PET/MRI (2020) (7)
- Chemistry of Nitrogen‐13 and Oxygen‐15 (2005) (7)
- Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models (2021) (6)
- 226 Reduced synaptic density in progressive supranuclear palsy and corticobasal syndrome, revealed by [11C]UCB-J PET (2020) (6)
- Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls (2013) (6)
- MICROGLIAL ACTIVATION AND TAU BURDEN PREDICT COGNITIVE DECLINE IN ALZHEIMER’S DISEASE (2019) (6)
- [11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease (2021) (6)
- Synthesis and evaluation of fluorine-18 and copper-64 labelled PBR radioligands† (2007) (6)
- Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers (2012) (6)
- Automated radiosynthesis of [ 11 C]UCB-J for imaging synaptic density by positron emission tomography (2020) (6)
- Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion (2019) (6)
- Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter. (2012) (5)
- Hydrogen loss from pentamethylcyclopentadienyl-ruthenium complexes : the synthesis and X-ray structure of [Ru(C5Me4CH2Cl)Cl3(Me2S)] (1991) (5)
- Reactions at functional silicon centres in compounds containing carbon-zinc bonds (1990) (5)
- Radiosynthesis of [18F]-Labelled Pro-Nucleotides (ProTides) (2020) (5)
- 18F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography (2020) (5)
- [Carboxyl‐11C]Labelling of Four High‐Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission Tomography (2018) (5)
- Synthesis of [11C]Flumazenil([11C]FMZ) (2012) (4)
- Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies (2017) (4)
- PET markers of tau and neuroinflammation are co-localized in progressive supranuclear palsy (2019) (4)
- Head injury: from the Glasgow Coma Scale to quo vadis. (2006) (4)
- A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein† (2020) (4)
- Single-step synthesis of N-succinimidyl-4-[18F]fluorobenzoate (2008) (3)
- 13th IIS (UK group) symposium (2004) (3)
- Synthesis of [18F]Fluoromisonidazole (1‐(2‐Hydroxy‐3‐[18F]Fluoropropyl)‐2‐Nitroimidazole, [18F]FMISO) (2012) (3)
- A simple and efficient automated cGMP-compliant radiosynthesis of [11 C]metomidate using solid phase extraction cartridge purification. (2019) (3)
- Synthesis of [18F]‐Fallypride (2012) (3)
- In vivo NMDA receptor function in people with NMDA receptor antibody encephalitis (2021) (3)
- Radiochemistry with Carbon‐11 (2020) (3)
- Imaging Tau, Neuroinflammation, and Aβ in Dementia With Lewy Bodies: A Deep‐Phenotyping Case Report (2018) (3)
- In Vivo 18 F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy (2022) (3)
- 14th International Isotope Society (UK group) symposium (2005) (3)
- Synaptic loss in behavioural variant frontotemporal dementia revealed by UCB-J PET (2022) (3)
- Radiosynthesis of Carbon-11 Labeled Puromycin as a Potential PET Candidate for Imaging Protein Synthesis in Vivo. (2016) (3)
- Hypoxia and tissue destruction in pulmonary tuberculosis (2016) (2)
- David James Silvester (2013) (2)
- Labelling and preliminary in vitro evaluation of the vasoactive peptide ET-1, a PET radioligand for the endothelin receptor (2000) (2)
- Radiosynthesis and preliminary in vivo studies with [11C]SB216763: The first brain penetrative PET tracer for imaging of glycogen synthase kinase-3 (GSK-3) (2013) (2)
- The first synthesis of ethyl 3-[ 18 F]fluorobenzoate using [ 18 F]fluoride (2008) (2)
- Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015. (2018) (2)
- The Disposition of a New Drug Propellant (HFA 134a) in Humans Studied by Fluorine-18 Labelling and Whole-Body γ-Counting (1995) (2)
- Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down's syndrome (2022) (2)
- Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline (2020) (2)
- [11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease (2021) (2)
- Imaging post-ischaemic cellular changes using 11C-flumazenil & microPET following temporary distal MCA occlusion in the spontaneous hypertensive rat (SHR) (2005) (2)
- MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol (2022) (2)
- FLUORESCENT COPPER(II) BIS(THIOSEMICARBAZONATES): FROM SYNTHESIS TO RADIOLABELLING, IN VITRO CYTOTOXICITY AND CONFOCAL FLUORESCENCE MICROSCOPY (2010) (1)
- Mapping the binding site topology of amyloid protein aggregates using multivalent ligands† (2021) (1)
- Synthesis of O‐methyl‐11C]Metomidate ([11C]‐MTO) (2012) (1)
- Synaptic Loss in Frontotemporal Dementia Revealed by [ 11C]UCB‐J Positron Emission Tomography (2022) (1)
- 16th International Isotope Society (UK group) Symposium (2008) (1)
- Comparison of 15oxygen positron emission tomography and near-infrared spectroscopy for measurement of cerebral physiology (2015) (1)
- Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study (2022) (1)
- Labelling of the CFC-alternative, 2H-heptafluoropropane (HFC 227ea), with fluorine-18 (1995) (1)
- [11C]PK11195 PET IMAGING REVEALS NEUROINFLAMMATION IN DEMENTIA WITH LEWY BODIES IS NEGATIVELY ASSOCIATED WITH DISEASE SEVERITY: NIMROD STUDY (2017) (1)
- Fifth International Stroke Summit (2009) (1)
- Perilesional F-18-deoxyglucose uptake following head injury: PET findings in patients receiving IV anesthetic agents (1998) (1)
- [18F]-ET-1 a pet radioligand for the endothelin receptor system — radiochemistry, position of label and in vivo biodistribution (2001) (1)
- Transvascular delivery of α-synuclein preformed fibrils, using the RVG9R delivery system, generates α-synuclein pathology in the duodenal myenteric plexus of non-transgenic rats (2021) (1)
- Intrinsically fluorescent bis(thiosemicarbazonates) with high kinetic stability in biological environments: synthetic scaffolds for optical/PET or SPECT dual-modality imaging agent (2014) (1)
- Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?: A Longitudinal Positron Emission Tomography-Magnetic Resonance Imaging Study (2023) (1)
- Fluorescent copper(II), gallium(III) and indium(III) bis(thiosemicarbazonates):Radiolabeling, cellular confocal fluorescence and PET imaging studies (2011) (1)
- The first nucleophilic synthesis of 3-[18F]fluoroethylbenzoate (2008) (1)
- 15th International Isotope Society (UK group) Symposium (2006) (1)
- [11C]PK11195 PET IN ALZHEIMER’S DISEASE AND PROGRESSIVE SUPRANUCLEAR PALSY: THE NIMROD STUDY (2017) (1)
- Preparation of the Serotonin Transporter PET Radiotracer 2-({2-[(Dimethylamino)methyl]phenyl}thio)-5-[18F]fluoroaniline (4-[18F]ADAM): Probing Synthetic and Radiosynthetic Methods (2019) (1)
- Early-stage 11C-Flumazenil PET predicts day-14 selective neuronal loss in a rodent model of transient focal cerebral ischemia (2020) (1)
- Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia. (2023) (1)
- Automated radiosynthesis and preclinical in vivo evaluation of [18F]Fluoroethylpuromycin as a potential radiotracer for imaging protein synthesis with PET. (2022) (1)
- Comparison of the reactivities of the compounds (Me3Si)2C(SiMe2OMe)(SiMe2Cl) and (MeOMe2Si)3C(SiMe2Cl). Crystal structure of (MeOMe2Si)3CSiPh2H (1991) (1)
- Amyloid and tau deposition influences cognitive decline in Down syndrome (2021) (0)
- Comparison of Lorazepam [7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2 H -1,4-benzodiazepin-2-one] Occupancy of Rat Brain (cid:1) -Aminobutyric Acid A Receptors Measured Using in Vivo [ 3 H]Flumazenil (8-Fluoro 5,6-dihydro-5-methyl-6-oxo-4 H -imidazo[1,5- a ][1,4]benzodiazepine-3-carboxylic Ac (2007) (0)
- Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2011 (2012) (0)
- (S)‐1‐(2,3‐Diaminophenoxy)‐3‐(N‐tert‐butylamino)propan‐2‐ol. Simplified Asymmetric Synthesis with CD and Chiral HPLC Analysis. (1992) (0)
- Mapping the binding site topology of amyloid protein aggregates using multivalent ligands. (2021) (0)
- Imaging brain fibrillar β-amyloid in adults with Down syndrome (DS) using [11C] PiB-PET: acceptability, feasibility and preliminary results (2011) (0)
- Abstracts of the 26th international isotope society (UK group) symposium: Synthesis & applications of labelled compounds 2017 (2018) (0)
- Interrogating changes in cerebral glucose availability, delivery, uptake and phosphorylation after traumatic brain injury; an (15)oxygen and F-18-fluorodeoxyglucose positron emission tomography study (2017) (0)
- Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) (0)
- Multimodal imaging markers of tau, neuroinflammation and atrophy to predict clinical progression in progressive supranuclear palsy (2020) (0)
- Cortical tau is associated with microstructural imaging biomarkers of neurite density and dendritic complexity in Alzheimer's disease. (2023) (0)
- 18F-AV1451 PET imaging and white matter changes in progressive supranuclear palsy (2019) (0)
- A simplified acquisition protocol for dynamic [18F]-FMISO PET studies of colorectal tumours (2016) (0)
- Abstracts of the 27th International Isotope Society (UK group) symposium: Synthesis and applications of labelled compounds 2018 (2019) (0)
- Assessment of brain tissue hypoxia during and after MCA occlusion in the rat using 18F-fluoromisonidazole (F-MISO) and microPET (2006) (0)
- Abstract WMP84: Predicting Cortical Selective Neuronal Loss Using 11 C-flumazenil PET After Temporary Focal Ischemia in Spontaneously Hypertensive Rats (2019) (0)
- Imaging animal models of addiction (2007) (0)
- Diffusion structural network metrics as a predictor for Alzheimer’s disease diagnosis in Down syndrome using support vector machine classification (2020) (0)
- SPATIAL ASSOCIATIONS OF Aβ WITH TAU DEPOSITION IN DOWN SYNDROME (2019) (0)
- Biotin labelling with [F-18]FDG, [F-18]fluoride and dendrons for pre-targeted imaging (2012) (0)
- Quantification of [18F]-FMISO binding in colorectal tumours using dynamic PET data: VOI- and voxel-based approaches (2016) (0)
- Development and Application of Imaging Probes for Molecular Imaging by Positron Emission Tomography (2022) (0)
- 15O-PET shows that cerebral blood volume is increased in head injury, but may still not be the dominant cause of intracranial hypertension (2005) (0)
- Radiosynthesis of [11C]Carboxamides via Reaction of [11C]CO2 Captured by a Cu(I)‐Based Catalyst System with Boronic Acid Ester Precursors (2015) (0)
- Speaker 3: Saori Tanaka, Japan (2016) (0)
- Front Cover: [Carboxyl‐11C]Labelling of Four High‐Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission Tomography (ChemMedChem 2/2018) (2018) (0)
- The Inverse Electron Demand Diels Alder Cycloaddition with Carbon-11 and Fluorine-18 - A Gateway to Pretargeted Imaging across the Blood-Brain Barrier. (2023) (0)
- PERILESIONAL 18F-DEOXYGLUCOSE UPTAKE FOLLOWING HEAD INJURY: PET FINDINGS IN PATIENTS RECIEVING IV ANESTHETIC AGENTS.: 903 (1998) (0)
- Synthesis, Crystal Structure and Reactions of the Dimeric Organolithium Compound ((((MeO)Me2Si)3CLi)2). (1992) (0)
- IN VIVO MAPPING OF TAU DEPOSITION, PERFUSION, AND CORTICAL THINNING IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE (2017) (0)
- 11 C-metomidate PET-CT in primary aldosteronism: five possible indications for a non-invasive alternative to adrenal vein sampling (2015) (0)
- Speaker 1: John O’Brien, UK (2016) (0)
- Cocaine Reinforcement Nucleus Accumbens D 2 / 3 Receptors Predict Trait Impulsivity and (2012) (0)
- Direct, Nucleophilic Radiosynthesis of [18F]Trifluoroethyl Tosylate (2015) (0)
- Establishing a Shared Imaging Research Infrastructure in the UK - A BioImagingUK White Paper (2020) (0)
- MAPPING AMYLOID DEPOSITION ON CORTICAL ATROPHY IN DOWN SYNDROME: A COMBINED BASELINE AND 2-YEAR LONGITUDINAL ANALYSIS (2018) (0)
- INVESTIGATE THE RELATIONSHIP BETWEEN TAU AND NEUROINFLAMMATION IN ALZHEIMER’S DISEASE USING PET AND REACTION RATE MODELLING (2017) (0)
- INVESTIGATION OF THE RELATIONSHIP BETWEEN TAU AND NEUROINFLAMMATION IN ALZHEIMER’S DISEASE USING PET AND REACTION MODELLING (2017) (0)
- Synaptic loss in behavioural variant of frontotemporal dementia:an in vivo [11C]UCB‐J PET study (2022) (0)
- MicroTSHoma: an emerging clinical entity with 'atypical' biochemical features and often 'normal' imaging characteristics on MRI (2016) (0)
- [11C]PK11195 PET IMAGING REVEALS NEUROINFLAMMATION IN DEMENTIA WITH LEWY BODIES IS NEGATIVELY ASSOCIATED WITH DISEASE SEVERITY: NIMROD STUDY (2017) (0)
- Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome (2022) (0)
- Evaluation of novel fluorinated puromycin analogues as potential candidates for PET imaging of protein synthesis (2016) (0)
- Changes in cerebral physiology following cranioplasty: a 15oxygen positron emission tomography study (2008) (0)
- GE PETtrace and associated systems, 4 years experience in Cambridge (2001) (0)
- Abstract PD6-09: Herpet study- PET imaging of HER2 expression in breast cancer using the novel Affibody tracer [18F]GE-226, a first in patient study (2021) (0)
- [11C]PK11195 PET IN ALZHEIMER’S DISEASE AND PROGRESSIVE SUPRANUCLEAR PALSY: THE NIMROD STUDY (2017) (0)
- Molecular pathology and synaptic loss in primary tauopathies: UCB-J PET study (2021) (0)
- Studies towards the Ga-68, Cu-64, Zr-89 and In-111 radiolabelling of small molecules and nanoparticles-multimodality PET or SPECT and optical imaging devices (2012) (0)
- ESTABLISHMENT OF A PET RADIOTRACER NETWORK FOR DEMENTIA RESEARCH (2017) (0)
- IN VIVO MAPPING OF TAU DEPOSITION, PERFUSION, AND CORTICAL THINNING IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE (2017) (0)
- Featured Article The pattern of amyloid accumulation in the brains of adults with Down syndrome (2015) (0)
- Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography (2020) (0)
- DEEP AND FREQUENT PHENOTYPING STUDY: PET AND MR IMAGING PROTOCOL (2017) (0)
- Synthesis of [18F]fluoromethane and [18F]fluorohaloalkanes using solid-phase organic chemistry (2006) (0)
- Radiochemical synthesis and automation of an 18F-radiolabelled oligonucleotide for PET imaging of miRNA-223 in relation to neuroinflammation (2022) (0)
- Effects of oral methylphenidate on [18F]fallypride binding in healthy volunteers and adults with attention-deficit hyperactivity disorder (ADHD) (2009) (0)
- Corrigendum to "DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits". Neurobiology of Disease 134 (2020) 104629 (2020) (0)
- ACUTE MICROGLIAL ACTIVATION IN TRAUMATIC BRAIN INJURY: A [11C](R) PK11195 POSITRON EMISSION TOMOGRAPHY STUDY (2016) (0)
- Coexisting low cerebral blood flow and volume in head injury is due to microvascular ischaemia, not hypometabolism: H-1 (2005) (0)
- Comparison of Lorazepam Occupancy of Rat Brain GABAA Receptors Measured Using In Vivo [H]Flumazenil Binding and [C]Flumazenil microPET (2006) (0)
- DEEP AND FREQUENT PHENOTYPING STUDY: PET AND MR IMAGING PROTOCOL (2017) (0)
- Automated GMP production of [11C]PR04.MZ via the captive solvent method and PET studies in non-human primates: A promising tracer for extrastriatal DAT imaging (2010) (0)
- IMAGING IN DEMENTIA (2016) (0)
- In vitro evaluation of GPR17 radioligands as potential CNS stem cell imaging agents (2021) (0)
- Consumption in the Ischemic Human Brain Local Relationships Between Restricted Water Diffusion and Oxygen (2006) (0)
- The role of dopamine in sustained attention: Imaging the effects of methylphenidate in ADHD patients and healthy controls (2010) (0)
- Comparison of the Reactivities of the Compounds (Me3Si)2C(SiMe2OMe)( SiMe2Cl) and (MeOMe2Si)3C(SiMe2Cl). Crystal Structure of (MeOMe2Si) 3CSiPh2H. (1991) (0)
- Homochiral Radioligands for PET: Aspects of Asymmetric Synthesis, Analysis and Behaviour In Vivo (1995) (0)
- DEVELOPMENT OF A MULTI-MODALITY PLATFORM FOR OLIGOMERIC PROTEIN AGGREGATE IMAGING (2017) (0)
- OrbitofrontalDopamineDepletionUpregulatesCaudate DopamineandAltersBehaviorviaChangesin ReinforcementSensitivity (2014) (0)
- CHARACTERISATION OF THE BINDING PROFILE OF THE COMPOUND PTP-TFE TOWARD BETA-AMYLOID (Aβ) AGGREGATES SHOWS PREFERRED BINDING TO OLIGOMERS (2018) (0)
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