Frans Van Roy

Frans Van Roy's AcademicInfluence.com Rankings

Frans Van Roy

Biology

#4461

World Rank

#6645

Historical Rank

Molecular Biology

#633

World Rank

#648

Historical Rank

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Biology

Why Is Frans Van Roy Influential?

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According to Wikipedia, Frans Van Roy is a Belgian molecular biologist and professor at the University of Ghent . He is head of the VIB Department for Molecular Biomedical Research, UGent. His research interest is on the molecular mechanisms underlying the pathology and the cure of cancer and inflammation-related disorders.

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Frans Van Roy's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. (2001) (1396)
Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion (1989) (1018)
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene (1993) (963)
Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (2000) (742)
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. (2003) (648)
Involvement of members of the cadherin superfamily in cancer. (2009) (645)
The p300/CBP acetyltransferases function as transcriptional coactivators of β‐catenin in vertebrates (2000) (630)
Mutations of the human E‐cadherin (CDH1) gene (1998) (610)
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell–cell junctions (2005) (556)
A novel role for p120 catenin in E-cadherin function (2002) (543)
E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. (1996) (471)
Molecular evolution of the cadherin superfamily. (2009) (422)
α-Catenin-Vinculin Interaction Functions to Organize the Apical Junctional Complex in Epithelial Cells (1998) (352)
E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis. (1997) (349)
Simultaneous loss of E‐cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ (1997) (304)
Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. (1999) (255)
Protein Binding and Functional Characterization of Plakophilin 2 (2002) (237)
The E-cadherin/catenin complex in invasion and metastasis. (1996) (234)
Unraveling signalling cascades for the Snail family of transcription factors. (2005) (234)
Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1). (1995) (222)
The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program. (2005) (214)
The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer. (1999) (207)
Transition from the noninvasive to the invasive phenotype and loss of alpha-catenin in human colon cancer cells. (1995) (184)
Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy. (2013) (171)
Defining desmosomal plakophilin-3 interactions (2003) (169)
Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. (1998) (162)
Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. (1999) (161)
Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin. (2004) (142)
Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression (2003) (142)
Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. (1999) (139)
A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (2005) (138)
Role of cell–cell adhesion complexes in embryonic stem cell biology (2014) (119)
Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog (2016) (118)
The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness (2001) (118)
A unique and specific interaction between αT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs (2007) (117)
Tumour invasion: effects of cell adhesion and motility. (1992) (115)
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. (1993) (113)
How and when do tumor cells metastasize? (1993) (112)
Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas. (1998) (111)
Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism. (1987) (110)
New insights into the evolution of metazoan cadherins. (2011) (106)
Alpha-Catenins Control Cardiomyocyte Proliferation by Regulating Yap Activity (2015) (102)
E‐cadherin gene alterations are rare events in thyroid tumors (1997) (102)
Protein Kinase C Activation Upregulates Intercellular Adhesion of α-Catenin–negative Human Colon Cancer Cell Variants via Induction of Desmosomes (1997) (101)
Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro. (1993) (100)
E-Cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells. (2003) (99)
Genomic organization of the human beta-catenin gene (CTNNB1). (1996) (97)
Evolution and diversity of cadherins and catenins. (2017) (95)
The transcription factor ZEB1 (δEF1) represses Plakophilin 3 during human cancer progression (2007) (91)
Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo. (1989) (87)
Beyond E-cadherin: roles of other cadherin superfamily members in cancer (2014) (85)
Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver. (2008) (85)
Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia (2012) (82)
Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se. (1991) (80)
Activation of the E-cadherin/catenin complex in human MCF-7 breast cancer cells by all-trans-retinoic acid. (1995) (77)
Cytoplasmic redistribution of E-cadherin-catenin adhesion complex is associated with down-regulated tyrosine phosphorylation of E-cadherin in human bronchopulmonary carcinomas. (1998) (76)
The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-β production (2006) (75)
Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. (2008) (74)
Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment. (2005) (73)
Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells. (1994) (71)
Insulin‐like growth factor‐I receptor, E‐cadherin and αv integrin form a dynamic complex under the control of α‐catenin (2008) (69)
Syndecan-1 expression in mammary epithelial tumor cells is E-cadherin-dependent. (1996) (69)
The Protein-tyrosine Phosphatase SHP-1 Binds to and Dephosphorylates p120 Catenin* (2000) (68)
Cancer metastasis: negative regulation by an invasion-suppressor complex. (1995) (67)
Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity. (1988) (66)
Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer. (2008) (64)
GATA-4 and MEF2C transcription factors control the tissue-specific expression of the alphaT-catenin gene CTNNA3. (2004) (61)
alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. (2001) (60)
E-cadherin and metastasin (mts-1/S100A4) expression levels are inversely regulated in two tumor cell families. (1998) (60)
Diverse functions of p120ctn in tumors. (2007) (60)
p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus (2004) (59)
Isolation and Characterization of XKaiso, a Transcriptional Repressor That Associates with the Catenin Xp120 ctn in Xenopus laevis * (2002) (59)
Canonical Wnt Signaling Controls Proliferation of Retinal Stem/Progenitor Cells in Postembryonic Xenopus Eyes (2008) (59)
Quantitative cell dispersion analysis: New test to measure tumor cell aggressiveness (2001) (59)
A Constitutional Translocation t(1;17)(p36.2;q11.2) in a Neuroblastoma Patient Disrupts the Human NBPF1 and ACCN1 Genes (2008) (56)
Expression of an exogenous tumor necrosis factor (TNF) gene in TNF-sensitive cell lines confers resistance to TNF-mediated cell lysis. (1992) (55)
Insulin-like growth factor-I receptor, E-cadherin and alpha v integrin form a dynamic complex under the control of alpha-catenin. (2008) (55)
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line. (1991) (53)
Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient? (1998) (52)
Regulation of the invasion suppressor function of the cadherin/catenin complex. (1996) (52)
Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion. (1997) (51)
Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo. (1991) (49)
Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling. (2012) (49)
Functions of p120ctn in development and disease. (2012) (48)
Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes. (1986) (47)
E-cadherin expression: a counterbalance for cancer cell invasion. (1992) (45)
Intercalated Discs and Arrhythmogenic Cardiomyopathy (2014) (45)
Assessment of the CTNNA3 gene encoding human αT-catenin regarding its involvement in dilated cardiomyopathy (2003) (44)
New insights into the evolution of metazoan cadherins and catenins. (2013) (44)
Influence of basement membrane molecules on directional migration of human breast cell lines in vitro. (1991) (44)
Nanos genes and their role in development and beyond (2018) (44)
Improved localization of phosphorylation sites in simian virus 40 large T antigen (1983) (43)
Delta-protocadherins in health and disease. (2013) (42)
Are oncogenes involved in invasion and metastasis? (1986) (41)
Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily. (1998) (41)
Cadherin-mediated cell-cell adhesion in the testis. (2005) (41)
E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. (2006) (38)
Metazoan evolution of the armadillo repeat superfamily (2017) (38)
Assignment of the human beta-catenin gene (CTNNB1) to 3p22-->p21.3 by fluorescence in situ hybridization. (1995) (38)
Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes. (1993) (37)
Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy (2002) (37)
Numerical evaluation of the invasion of closely related cell lines into collagen type I gels. (1991) (36)
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation. (1993) (36)
Lymphokines and monokines in anti-cancer therapy. (1986) (36)
NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest (2015) (35)
A flexible integrative approach based on random forest improves prediction of transcription factor binding sites (2012) (35)
Differential downregulation of alphaT-catenin expression in placenta: trophoblast cell type-dependent imprinting of the CTNNA3 gene. (2004) (35)
Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. (2000) (34)
Synergistic induction of interleukin‐6 by tumor necrosis factor and lithium chloride in mice: Possible role in the triggering and exacerbation of psoriasis by lithium treatment (1992) (33)
Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development. (2010) (33)
Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer. (1993) (32)
Cadherins in cancer. (2004) (32)
The Transcriptional Repressor Kaiso Localizes at the Mitotic Spindle and Is a Constituent of the Pericentriolar Material (2010) (31)
TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis (2015) (30)
Tumor necrosis factor cytotoxicity is associated with phospholipase D activation. (1993) (30)
Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma. (2010) (30)
Expression of protocadherin‐1 (Pcdh1) during mouse development (2008) (30)
Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons (2004) (29)
Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression. (1991) (28)
The human and murine protocadherin‐β one‐exon gene families show high evolutionary conservation, despite the difference in gene number (2001) (28)
Ancient Origin of the CARD–Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions (2018) (27)
Chicken β‐globin insulator overcomes variegation of transgenes in Xenopus embryos (2008) (27)
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine. (1993) (26)
p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification (2016) (26)
Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. (1999) (26)
TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells. (1989) (25)
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease. (2004) (25)
The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. (1999) (23)
In vivo tracing of canonical Wnt signaling in Xenopus tadpoles by means of an inducible transgenic reporter tool (2006) (23)
Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells. (2012) (23)
Variant HNF1 modulates epithelial plasticity of normal and transformed ovary cells. (2008) (23)
Hormone sensitivity in vitro and in vivo of v‐ras‐transfected mcf‐7 cell derivatives (1990) (23)
Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25‐kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients (2002) (23)
Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis. (2008) (23)
Direct control of Hoxd1 and Irx3 expression by Wnt/beta-catenin signaling during anteroposterior patterning of the neural axis in Xenopus. (2010) (22)
Three-dimensional reconstruction of the intercalated disc including the intercellular junctions by applying volume scanning electron microscopy (2018) (21)
Qualitative and Quantitative Analysis of Tumour Invasion In Vivo and In Vitro (1987) (21)
Low nucleosome occupancy is encoded around functional human transcription factor binding sites (2008) (21)
Isolation and characterization of a human pseudogene (CTNNAP1) for alpha E-catenin (CTNNA1): assignment of the pseudogene to 5q22 and the alpha E-catenin gene to 5q31. (1995) (21)
The NBPF1 promoter has been recruited from the unrelated EVI5 gene before simian radiation. (2009) (20)
The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial–mesenchymal transition (2015) (20)
Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription. (2015) (20)
Efficient and User-Friendly Pluripotin-based Derivation of Mouse Embryonic Stem Cells (2011) (19)
Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma (2016) (19)
Interaction of α-Catulin with Dystrobrevin Contributes to Integrity of Dystrophin Complex in Muscle* (2012) (19)
Global Inhibition of Lef1/Tcf-dependent Wnt Signaling at Its Nuclear End Point Abrogates Development in Transgenic Xenopus Embryos* (2004) (19)
Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. (2005) (18)
Expression of E-cadherin in embryogenetic ingression and cancer invasion. (1993) (18)
The cardiac protein αT-catenin contributes to chemical-induced asthma. (2015) (18)
Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent. (1990) (18)
αT-catenin in restricted brain cell types and its potential connection to autism (2016) (18)
Metabolic turnover of phosphorylation sites in simian virus 40 large T antigen (1983) (16)
An efficient and reliable multiplex PCR‐SSCP mutation analysis test applied to the human E‐cadherin gene (1997) (16)
A distance difference matrix approach to identifying transcription factors that regulate differential gene expression (2007) (16)
Growth inhibition in clonal subpopulations of a human epithelioid sarcoma cell line by retinoic acid and tumour necrosis factor alpha. (1996) (15)
Homotypic cell-cell adhesion molecules and tumor invasion. (1992) (15)
The human alphaE-catenin gene CTNNA1: mutational analysis and rare occurrence of a truncated splice variant. (2002) (14)
Breaking the Species Barrier: Derivation of Germline‐Competent Embryonic Stem Cells from Mus spretus × C57BL/6 Hybrids (2004) (14)
Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride. (1991) (14)
N-cadherin stabilises neural identity by dampening anti-neural signals (2019) (14)
ARVCF depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS‐like phenotypes in Xenopus (2011) (14)
Micro‐encapsulation of MDCK‐ras‐e cells prevents loss of E‐cadherin invasion‐suppressor function in vivo (1994) (13)
Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice. (2012) (13)
Phosphorylation patterns of tumour antigens in cells lytically infected or transformed by simian virus 40 (1981) (12)
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter (1990) (12)
Assignment1 of the plakophilin-2 gene (PKP2) and a plakophilin-2 pseudogene (PKP2P1) to human chromosome bands 12p11 and 12p13, respectively, by in situ hybridization (2000) (11)
Mutation of alpha-catenin results in invasiveness of human HCT-8 colon cancer cells. (1997) (11)
Changing the name of the NBPF/DUF1220 domain to the Olduvai domain (2018) (11)
Protein kinase activities in immune complexes of simian virus 40 large T-antigen and transformation-associated cellular p53 protein (1984) (11)
A proposal to change the name of the NBPF/DUF1220 domain to the Olduvai domain. (2017) (10)
Structure-function relationship of tumour necrosis factor and its mechanism of action. (1987) (10)
hMSH6 deficiency and inactivation of the αE-catenin invasion-suppressor gene in HCT-8 colon cancer cells (2004) (10)
Interference with simian virus 40 DNA replication by adenovirus type 2 during mixed infection of monkey cells (1978) (10)
Partial transformation of human tumor cell lines showing defective interaction between unusual p53 gene product and SV40 large-T antigen. (1990) (9)
N-cadherin is Required for Cytodifferentiation during Zebrafish Odontogenesis (2013) (9)
Oxygenation of tumors derived from ras transformed cells. (1990) (9)
Writing readable prose (2006) (9)
Changes in gene expression and protein phosphorylation in murine cells, transformed or abortively infected with wild type and mutant simian virus 40. (1983) (9)
Pathology of tumours produced in syngeneic Fischer rats by fibroblast-like cells before and after transfection with oncogenes. (1987) (8)
Insertion of an HERV(K) LTR in the intron of NBPF3 is not required for its transcriptional activity. (2007) (8)
GC Content of Early Metazoan Genes and Its Impact on Gene Expression Levels in Mammalian Cell Lines (2018) (8)
Assignment1 of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3 (1999) (7)
Tumor necrosis factor: a potential antitumor agent? (1987) (7)
Inactivation of p120 catenin in mice disturbs intrahepatic bile duct development and aggravates liver carcinogenesis. (2016) (7)
Isolation and characterization of a specific deletion mutant of human adenovirus type 2. (1979) (7)
Armc8 is an evolutionarily conserved armadillo protein involved in cell–cell adhesion complexes through multiple molecular interactions (2018) (7)
[The human E-cadherin/catenin complex: a potent invasion and tumor suppressor]. (1998) (6)
Structure of the components of the adenovirus-simian virus 40 hybrid population Ad2++HEY and reciprocal molecular interactions. (1978) (6)
Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice (2020) (4)
Effect of oncogene transfection or passage in vivo on malignant phenotypes of rat2 cells. (1989) (4)
Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange. (2017) (4)
Genome organisation of the FBR-osteosarcoma virus complex: identification of a subgenomic fos-specific message. (1986) (4)
Molecular biology of minimal invasion. (1988) (4)
Molecular cloning of an alternative human alphaE-catenin cDNA. (1997) (2)
Description and Mapping of the Resistance of DBA/2 Mice to TNF-Induced Lethal Shock1 (2007) (2)
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors (2012) (2)
Metazoan evolution of the armadillo repeat superfamily (2016) (1)
Modifying PCDH19 levels affects cortical interneuron migration (2022) (1)
Nanos genes and their role in development and beyond (2018) (1)
A new mouse model to study the role of ectopic Nanos3 expression in cancer (2019) (1)
Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms (2022) (1)
Regulation of expression of a cistron in the RNA bacteriophage MS2. (1974) (1)
Molecular biology of cadherins. Preface. (2013) (0)
The CARD-CC/Bcl10/paracaspase signaling complex is functionally conserved since the last common ancestor of Planulozoa (2016) (0)
Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice (2020) (0)
A new mouse model to study the role of ectopic Nanos3 expression in cancer (2019) (0)
NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest (2015) (0)
Proceedings: Studies on the excision process of SV40-DNA during infection with Adeno-SV40-hybrid Ad.2++ HEY. (1976) (0)
Efficient and User-Friendly Pluripotin-based Derivation of Mouse Embryonic Stem Cells (2011) (0)
Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms (2022) (0)

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What Schools Are Affiliated With Frans Van Roy?

Frans Van Roy is affiliated with the following schools:

Ghent University