Franz F. Hefti
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Franz F. Heftibiology Degrees
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Neuroscience
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Biology
Franz F. Hefti's Degrees
- Bachelors Biology University of Zurich
- PhD Neuroscience University of Zurich
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(Suggest an Edit or Addition)Franz F. Hefti's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections (1986) (1372)
- Characterization of a multicomponent receptor for GDNF (1996) (1078)
- Distinct mechanism for antidepressant activity by blockade of central substance P receptors. (1998) (1020)
- Use of florbetapir-PET for imaging beta-amyloid pathology. (2011) (938)
- Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis (2016) (716)
- NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain? (1983) (701)
- Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain (1995) (696)
- Precursor control of neurotransmitter synthesis. (1980) (666)
- Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons (1995) (617)
- Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. (1991) (615)
- Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II (1990) (539)
- Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization (1980) (514)
- Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons (1985) (475)
- Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases (1989) (469)
- Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions (1984) (447)
- Preclinical Properties of 18F-AV-45: A PET Agent for Aβ Plaques in the Brain (2009) (395)
- Toxicity of 6‐hydroxydopamine and dopamine for dopaminergic neurons in culture (1990) (357)
- Novel class of pain drugs based on antagonism of NGF. (2006) (356)
- Regulated Release and Polarized Localization of Brain-Derived Neurotrophic Factor in Hippocampal Neurons (1996) (344)
- Nerve growth factor and Alzheimer's disease (1986) (339)
- Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes (1988) (308)
- Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain (1986) (288)
- Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation (1995) (271)
- Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain (1992) (269)
- The influence of heregulins on human Schwann cell proliferation (1995) (255)
- Neurotrophic factor therapy for nervous system degenerative diseases. (1994) (253)
- K‐252 Compounds: Modulators of Neurotrophin Signal Transduction (1992) (252)
- Stimulation of nigrostriatal dopamine neurones by nicotine (1982) (242)
- Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA (1980) (226)
- Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment (1988) (212)
- Regulated neurotrophin receptor responsiveness during neuronal migrationand early differentiation (1994) (208)
- Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer's pathology (2016) (201)
- A fluorometric micromethod for the simultaneous determination of serotonin, noradrenaline and dopamine in milligram amounts of brain tissue. (1974) (193)
- Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content (1986) (190)
- Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates (1991) (189)
- BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity (1992) (188)
- The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth FACTOR-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture (1993) (182)
- Nonaminergic striatal neurons convert exogenous l‐dopa to dopamine in parkinsonism (1980) (180)
- The site of dopamine formation in rat striatum after L-dopa administration. (1981) (180)
- Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions (1985) (177)
- Potential use of nerve growth factor to treat Alzheimer's disease (1989) (175)
- Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid (1992) (174)
- Use of Florbetapir-PET for Imaging-Amyloid Pathology (2011) (172)
- Is Alzheimer disease caused by lack of nerve growth factor? (1983) (171)
- Pharmacology of neurotrophic factors. (1997) (161)
- Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE (2015) (161)
- BDNF and NGF treatment in lesioned rats: effects on cholinergic function and weight gain. (1992) (161)
- Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease (1989) (160)
- Systemic interleukin-1β decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation (1993) (145)
- Long‐term administration of L‐DOPA does not damage dopaminergic neurons in the mouse (1981) (142)
- Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics (2014) (140)
- Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus (1993) (138)
- Molecular basis for catecholaminergic neuron diversity. (2004) (136)
- Predicting Alzheimer’s disease progression using multi-modal deep learning approach (2019) (136)
- Neurotrophin‐3 reverses experimental cisplatin‐induced peripheral sensory neuropathy (1995) (133)
- Trophic actions of transforming growth factor α on mesencephalic dopaminergic neurons developing in culture (1993) (130)
- Astrocytes protect cultured neurons from degeneration induced by anoxia (1987) (128)
- Ligand-induced down-regulation of trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neurons (1997) (126)
- Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro (1988) (124)
- Induction of tyrosine hydroxylase by nerve growth factor and by elevated K+ concentrations in cultures of dissociated sympathetic neurons (1982) (124)
- Correlation of Amyloid PET Ligand Florbetapir F 18 Binding With A&bgr; Aggregation and Neuritic Plaque Deposition in Postmortem Brain Tissue (2012) (115)
- Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury. (1997) (112)
- Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat (1991) (109)
- Partial lesions of the nigrostriatal pathway in the rat Acceleration of transmitter synthesis and release of surviving dopaminergic neurones by drugs (1985) (106)
- Immunohistochemical Visualization of Brain‐derived Neurotrophic Factor in the Rat Brain (1995) (103)
- A quantitative correlation between single unit activity and fluorescence intensity of dopamine neurones in zona compacta of substantia nigra, as demonstrated under the influence of nicotine and physostigmine (1976) (101)
- Neurotrophin‐4/5 Promotes Survival and Differentiation of Rat Striatal Neurons Developing in Culture (1994) (100)
- The case for soluble Aβ oligomers as a drug target in Alzheimer's disease. (2013) (95)
- BDNF and trkB mRNA expression in the hippocampal formation of aging rats (1993) (94)
- Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions. (1980) (93)
- Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: Effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration (1994) (91)
- A simple, sensitive method for measuring 3,4-dihydroxyphenylacetic acid and homovanillic acid in rat brain tissue using high-performance liquid chromatography with electrochemical detection. (1979) (90)
- Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: Evidence from lesion and chronic cholinergic drug treatment studies (1993) (89)
- Selective Destruction of Cultured Dopaminergic Neurons from Fetal Rat Mesencephalon by 1‐Methyl‐4‐Phenylpyridinium: Cytochemical and Morphological Evidence (1988) (88)
- Guidance of acetylcholinesterase-containing fibres by target tissue in co-cultured brain slices (1984) (87)
- Effects of oral L-tyrosine administration on CSF tyrosine and homovanillic acid levels in patients with Parkinson's disease. (1982) (87)
- Cerebellar Brain-Derived Neurotrophic Factor–TrkB Defect Associated with Impairment of Eyeblink Conditioning in StargazerMutant Mice (1998) (85)
- Rapid Phosphorylation of Phospholipase Cγ 1 by Brain‐Derived Neurotrophic Factor and Neurotrophin‐3 in Cultures of Embryonic Rat Cortical Neurons (1993) (85)
- GDNF Induces a Dystonia-like State in Neonatal Rats and Stimulates Dopamine and Serotonin Synthesis (1996) (84)
- Nerve growth factor promotes development of the rat septo-hippocampal cholinergic projection in vitro (1987) (84)
- 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in cultures of dissociated rat mesencephalic neurons (1986) (80)
- Aromatic L‐amino acid decarboxylase in rat corpus striatum (1981) (80)
- Chronic intranigral administration of brain-derived neurotrophic factor produces striatal dopaminergic hypofunction in unlesioned adult rats and fails to attenuate the decline of striatal dopaminergic function following medial forebrain bundle transection (1993) (79)
- Long-term effects of nerve growth factor and neural transplants on behavior of rats with medial septal lesions (1986) (79)
- Pharmacological profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. (1989) (79)
- Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia (1996) (77)
- Toxicity of 1‐Methyl‐4‐Phenylpyridinium for Rat Dopaminergic Neurons in Culture: Selectivity and Irreversibility (1990) (76)
- Requirements for a lead compound to become a clinical candidate (2008) (76)
- K‐252b Selectively Potentiates Cellular Actions and trk Tyrosine Phosphorylation Mediated by Neurotrophin‐3 (1992) (76)
- Implantation of PC12 cells into the corpus striatum of rats with lesions of the dopaminergic nigrostriatal neurons (1985) (75)
- Non-coding variability at the APOE locus contributes to the Alzheimer’s risk (2019) (74)
- Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons (2002) (73)
- Effect of recombinant human nerve growth factor on presynaptic cholinergic function in rat hippocampal slices following partial septohippocampal lesions: Measures of [3H]acetylcholine synthesis, [3H]acetylcholine release and choline acetyltransferase activity (1991) (72)
- Growth of dissociated neurons in culture dishes coated with synthetic polymeric amines (1984) (67)
- Florbetapir f-18: a histopathologically validated Beta-amyloid positron emission tomography imaging agent. (2011) (67)
- Distribution of [125I]nerve growth factor in the rat brain following a single intraventricular injection: Correlation with the topographical distribution of trk a messenger RNA-expressing cells (1993) (65)
- Long-term administration of mouse nerve growth factor to adult rats with partial lesions of the cholinergic septohippocampal pathway (1990) (64)
- Stimulation of GABAergic neuron differentiation by NT-4/5 in cultures of rat cerebral cortex. (1994) (62)
- Gangliosides alter morphology and growth of astrocytes and increase the activity of choline acetyltransferase in cultures of dissociated septal cells (1985) (62)
- Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo (1999) (61)
- Compensatory elevation of acetylcholine synthesis in vivo by cholinergic neurons surviving partial lesions of the septohippocampal pathway (1991) (61)
- Advancing Alzheimer's disease diagnosis, treatment, and care: Recommendations from the Ware Invitational Summit (2012) (58)
- Serotonergic neurones are not involved in action of L-dopa in Parkinson's disease (1980) (57)
- Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology (2020) (56)
- Effect of thyroid hormone analogs on the activity of choline acetyltransferase in cultures of dissociated septal cells (1986) (56)
- BDNF protection of basal forebrain cholinergic neurons after axotomy: complete protection of p75IMGFR‐positive cells (1993) (55)
- Development of cholinergic pedunculopontine neurons in vitro: Comparison with Cholinergic septal cells and response to nerve growth factor, ciliary neuronotrophic factor, and retinoic acid (1988) (55)
- Intrastriatal infusion of nerve growth factor after quinolinic acid prevents reduction of cellular expression of choline acetyltransferase messenger RNA and trkA messenger RNA, but not glutamate decarboxylase messenger RNA (1994) (55)
- 2 – Neurotrophic Factors: What Are They and What Are They Doing? (1993) (53)
- The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory (2019) (52)
- Nerve Growth Factor Promotes Survival of Septal Cholinergic Neurons After Injury (1986) (52)
- l-DOPA's mechanism of action in Parkinson's disease (1980) (51)
- Acute administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces dopamine and serotonin but accelerates norepinephrine metabolism in the rat brain. Effect of chronic pretreatment with MPTP. (1984) (51)
- Response of embryonic rat hippocampal neurons in culture to neurotrophin-3, brain-derived neurotrophic factor and basic fibroblast growth factor (1993) (51)
- Toxic effects of potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium on cultured rat dopaminergic neurons. (1989) (49)
- Protective effects of neurotrophin-4/5 and transforming growth factor-α on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid (1997) (48)
- The use of the exploratory IND in the evaluation and development of 18F-PET radiopharmaceuticals for amyloid imaging in the brain: a review of one company's experience. (2009) (48)
- Nerve Growth Factor and Alzheimer's Disease (1986) (48)
- Differential regulation of catalytic and non-catalytictrkB messenger RNAs in the rat hippocampus following seizures induced by systemic administration of kainate (1995) (46)
- Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells (1990) (46)
- Acetylcholine-rich transplants in the hippocampus: influence of intrinsic growth factors and application of nerve growth factor on choline acetyltransferase activity (1985) (46)
- Rationale for the planned clinical trials with nerve growth factor in Alzheimer's disease. (1989) (46)
- Dopamine release in rat striatum after administration ofl-DOPA as studied with in vivo electrochemistry (1981) (45)
- Neuromelanin synthesis in rat and human substantia nigra (1990) (44)
- Suppression of L‐dopa‐induced circling in rats with nigral lesions by blockade of central dopa‐decarboxylase (1984) (44)
- Stimulation of Phosphatidylinositol Hydrolysis by Brain‐Derived Neurotrophic Factor and Neurotrophin‐3 in Rat Cerebral Cortical Neurons Developing in Culture (1992) (43)
- K‐252b Is a Selective and Nontoxic Inhibitor of Nerve Growth Factor Action on Cultured Brain Neurons (1991) (43)
- Chronoamperometry in vivo: does it interfere with spontaneous neuronal activity in the brain? (1983) (43)
- Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA). (2011) (41)
- BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions. (1993) (41)
- The non‐peptidyl fungal metabolite L‐783,281 activates TRK neurotrophin receptors (2001) (41)
- High-performance size-exclusion chromatography: a buffer for the reliable determination of molecular weights of proteins. (1982) (41)
- SUBCELLULAR DISTRIBUTION OF DOPAMINE IN SUBSTANTIA NIGRA OF THE RAT BRAIN: EFFECTS OF γ‐BUTYROLACTONE AND DESTRUCTION OF NORADRENERGIC AFFERENTS SUGGEST FORMATION OF PARTICLES FROM DENDRITES 1 (1978) (40)
- Neurotrophins in the Central Nervous System (1992) (39)
- Biological and immunological properties of the nerve growth factor from bovine seminal plasma: Comparison with the properties of mouse nerve growth factor (1983) (39)
- Trophic effect of exogenous nerve growth factor on rat striatal cholinergic neurons: comparison between intraparenchymal and intraventricular administration. (1996) (39)
- Neurotrophin-induced trk receptor phosphorylation and cholinergic neuron response in primary cultures of embryonic rat brain neurons. (1992) (39)
- Trophic actions of IGF-I, IGF-II and insulin on cholinergic and dopaminergic brain neurons. (1991) (38)
- Huntington chorea is not associated with hyperactivity of nigrostriatal dopaminergic neurons (1982) (38)
- Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands (2011) (37)
- Protective effects of nerve growth factor and brain-derived neurotrophic factor on basal forebrain cholinergic neurons in adult rats with partial fimbrial transections. (1993) (37)
- 6-Hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra. (1994) (37)
- Intraventricular nerve growth factor administration prevents lesion-induced loss of septal cholinergic neurons in aging rats (1989) (37)
- Nerve growth factor is a neurotrophic factor for forebrain cholinergic neurons; implications for Alzheimer's disease. (1987) (36)
- Mechanism of action of short- and long-term L-DOPA treatment in parkinsonism: role of the surviving nigrostriatal dopaminergic neurons. (1984) (35)
- Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics (2019) (35)
- Large-scale genomics unveil polygenic architecture of human cortical surface area (2015) (34)
- Intraparenchymal NGF Injections in Adult and Aged Rats Induce Long-Lasting Trk Tyrosine Phosphorylation (1996) (33)
- Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures (1992) (32)
- Decarboxylation of exogenous L-DOPA in rat striatum after lesions of the dopaminergic nigrostriatal neurons: the role of striatal capillaries (1980) (31)
- The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor. (1999) (31)
- Down-regulation of phosphatidylinositol response to BDNF and NT-3 in cultures of cortical neurons (1993) (30)
- Neurotrophin-4/5 selectively protects nigral calbindin-containing neurons in rats with medial forebrain bundle transections (1996) (29)
- Effects of Chronic Basic Fibroblast Growth Factor Administration to Rats with Partial Flmbrial Transections on Presynaptic Cholinergic Parameters and Muscarinic Receptors in the Hippocampus: Comparison with Nerve Growth Factor (1993) (29)
- Progress in Parkinson's disease research--2 (1992) (28)
- Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits (2016) (28)
- An enzymatic—isotopic method for DOPA and its use for the measurement of dopamine synthesis in rat substantia nigra 1 (1976) (28)
- Paraquat and Parkinson's disease (1987) (28)
- l‐3, 4‐Dihydroxyphenylalanine and l‐5‐Hydroxytryptophan Decarboxylase Activities in Rat Striatum: Effect of Selective Destruction of Dopaminergic or Serotoninergic Input (1980) (28)
- Regional tyrosine levels in rat brain after tyrosine administration (2005) (27)
- Development of effective therapy for Alzheimer's disease based on neurotrophic factors (1994) (27)
- The decarboxylation of DOPA in the parkinsonian brain: in vivo studies on an animal model. (1980) (26)
- Diminished decarboxylation of l-dopa in rat striatum after intrastriatal injections of kainic acid (1980) (25)
- Regionally specific induction of BDNF and truncated trkB.T1 receptors in the hippocampal formation after intraseptal injection of kainic acid (1998) (25)
- Transmitter metabolism in substantia nigra after inhibition of dopaminergic neurones by butyrolactone (1976) (25)
- Use of a digital brain atlas to compare the distribution of NGF‐ and bFGF‐protected cholinergic neurons (1991) (24)
- Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study (2012) (24)
- Chronic administration of nerve growth factor and other neurotrophic factors to the brain (1988) (24)
- Pharmacology of nerve growth factor and discovery of tanezumab, an anti-nerve growth factor antibody and pain therapeutic. (2020) (23)
- Growth Factors and Alzheimer’s Disease (1991) (23)
- Dendritic dopamine: Studies on the release of endogenous dopamine from subcellular particles derived from dendrites of rat nigro-striatal neurons (1978) (22)
- Compensatory mechanisms in the nigrostriatal dopaminergic system in Parkinson's disease: studies in an animal model. (1982) (22)
- Potential use of nerve growth factor to treat Alzheimer's disease. (1989) (21)
- Regulation of hippocampal muscarinic receptor function by chronic nerve growth factor treatment in adult rats with fimbrial transections (1993) (21)
- 18F-florbetapir Positron Emission Tomography–determined Cerebral &bgr;-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery (2018) (21)
- Pharmacological stimulation reveals recombinant human nerve growth factor-induced increases of in vivo hippocampal cholinergic function measured in rats with partial fimbrial transections (1992) (20)
- Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun (1997) (20)
- Transient elevation in catalytic trkB mRNA during postnatal development of the rat brain. (1993) (20)
- Pharmacology of nerve growth factor in the brain. (1993) (20)
- A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data (2019) (19)
- Tyrosine Hydroxylase mRNA Expression by Dopaminergic Neurons in Culture: Effect of 1 ‐Methyl‐4‐Phenylpyridinium Treatment (1991) (19)
- TGFα stimulation of phosphatidylinositol hydrolysis in mesencephalic cultures requires neuron‐glia interactions (1993) (18)
- Multiple and interactive responses of central neurons to neurotrophic factors (1993) (17)
- Striatal acetylcholinesterase-containing interneurons innervate hippocampal tissue in co-cultured slices. (1985) (17)
- Heterodimeric Neurotrophins Induce Phosphorylation of Trk Receptors and Promote Neuronal Differentiation in PC12 Cells (*) (1995) (17)
- Spike activity and histofluorescence correlated in the giant dopamine neuron of Planorbis corneus (1979) (16)
- TrkA NGF receptor expression by non-cholinergic thalamic neurons. (1993) (16)
- IMT‐4/5 protects against adrenalectomy‐induced apoptosis of rat hippocampal granule cells (1996) (15)
- Epidermal Growth Factor Induces PC12 Cell Differentiation in the Presence of the Protein Kinase Inhibitor K‐252a (1994) (15)
- Gene Therapy for Parkinson’s Disease Associated with GBA1 Mutations (2021) (15)
- Neurotrophin-4/5 treatment reduces infarct size in rats with middle cerebral artery occlusion (1996) (14)
- Functional Consequences of a Single Nerve Growth Factor Administration Following Septal Damage in Rats (1993) (14)
- Progress in Parkinson Research (1989) (14)
- Mechanisms of MPP+ Neurotoxicity: Oxyradical and Mitochondrial Inhibition Hypotheses (1988) (13)
- Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: Selective toxicity of 1-methyl-4-(4′-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture (1990) (13)
- A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer’s disease (2016) (12)
- Neurotrophic factor therapy — Keeping score (1997) (12)
- Role of Nerve Growth Factor in the Central Nervous System (1988) (12)
- First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain (2018) (12)
- (778): RN624 (Anti-NGF) reduces pain and improves function in subjects with moderate to severe pain from osteoarthritis of the knee (2006) (12)
- ACU-193: A candidate therapeutic antibody that selectively targets soluble beta-amyloid oligomers (2013) (12)
- (18)F-AV-133: A Selective VMAT2-binding Radiopharmaceutical for PET Imaging of Dopaminergic Neurons. (2010) (11)
- Effects of chronic nerve growth factor treatment on hippocampal [3H]cytisine/ nicotinic binding sites and presynaptic nicotinic receptor function following fimbrial transections (1994) (11)
- An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging (2018) (11)
- Phase III trial results for the amyoid PET imaging agent Florbetapir F 18 (18F-AV-45): imaging to histopathologic correlations in an end-of-life human subject study (2010) (10)
- Randomized, Placebo Controlled Trial of NPT088, A Phage-Derived, Amyloid-Targeted Treatment for Alzheimer’s Disease (2019) (10)
- Emerging pharmacology of nerve growth factor (1991) (10)
- Development of neurotrophic factor therapy for Alzheimer's disease. (1996) (10)
- Acetaminophen metabolism by cytochrome P450 monooxygenases in Parkinson's disease (1989) (10)
- Reply from Hefti and Melamed (1981) (10)
- Nerve Growth Factor (1988) (10)
- Pharmacological activities in thermal proteins: relationships in molecular evolution. (1987) (10)
- Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis (1993) (9)
- Neurotrophic Factor Mimetics (1999) (9)
- Deafferentation removes calretinin immunopositive terminals, but does not induce degeneration of calbindin D‐28k and parvalbumin expressing neurons in the hippocampus of adult rats (1994) (9)
- CEP‐1347 increases ChAT activity in culture and promotes cholinergic neurone survival following fimbria‐fornix lesion (2000) (9)
- FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease (2020) (9)
- Lateralized hunger: Ipsilateral attenuation of cortical spreading depression-induced feeding after unilateral 6-OHDA injection into the substantia nigra (1979) (9)
- From genes to effective drugs for neurological and psychiatric diseases. (2001) (9)
- Retrograde transport of nerve growth factor from hippocampus and amygdala to trk A messenger RNA expressing neurons in paraventricular and reuniens nuclei of the thalamus (1995) (9)
- Regulatory issues in aging pharmacology (2006) (9)
- Muscarinic receptors on intact, cultured neurons. Characterization by [3H]quinuclidinylbenzilate binding (1983) (8)
- A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease (2020) (8)
- Trophic factors and their role in the postischemic brain. (1996) (8)
- Nerve Growth Factor Treatment for Alzheimer’s Disease: The Experience of the First Attempt at Intracerebral Neurotrophic Factor Therapy (1999) (8)
- Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization (2021) (7)
- Conformation as the Therapeutic Target for Neurodegenerative Diseases. (2017) (7)
- Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference (2018) (6)
- Neurotrophic Factors and Neurodegenerative Diseases (1991) (6)
- Adaptive Changes in Central Dopaminergic Neurons after Injury (1988) (6)
- Predicting Alzheimer’s disease progression using multi-modal deep learning approach (2019) (6)
- (1S,2R)-5-methoxy-1-methyl-2-(n-propylamino)tetralin ([+]-AJ-76) elevates transmitter synthesis in dopaminergic neurons surviving a partial nigrostriatal lesion (1987) (6)
- Promotion of neuronal survival in vitro by thermal proteins and poly(dicar☐ylic) amino acids (1991) (5)
- PR001 gene therapy improved phenotypes in models of Parkinson’s disease with GBA1 mutation (2020) (5)
- RELATION BETWEEN BRAIN TYROSINE AND CATECHOLAMINE SYNTHESIS (1979) (5)
- The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory (2019) (5)
- NERVE GROWTH FACTOR EFFECTS ON eNS NEURONS AND ON BEHAVIORAL RECOVERY FROM BRAIN DAMAGE (1988) (5)
- Synthesis and biological evaluation of radioiodinated N-2-(4-piperidyl)ethyl benzamides. (1993) (5)
- An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease (2022) (5)
- No relevance to Parkinson's (1991) (5)
- Bridging the Gap between Patients and Models (2015) (5)
- Neurotrophic Factor Therapy of Alzheimer’s Disease (1995) (4)
- The Role of Neurotrophins in the Central Nervous System: Significance for the Treatment of Neurodegenerative Diseases (1992) (4)
- Cholinergic Neurons of the Rat Forebrain in Slice Cultures; Interactions with Target Tissue and Effects of Nerve Growth Factor (1988) (4)
- Neurotrophic factors and Parkinson's disease. (1990) (3)
- Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment (2022) (3)
- Altered pharmacokinetics of l‐dopa metabolism (1985) (3)
- Selective Visualization of Rodent Locus Ceruleus by a Radiolabeled N‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Analog (1989) (3)
- Selective and non-selective trophic actions on central cholinergic and dopaminergic neurons in vitro. (1990) (3)
- Induction of non-catalytic TrkB neurotrophin receptors during lesion-induced synaptic rearrangement in the adult rat hippocampus. (1995) (3)
- Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology (2020) (3)
- Experimental Systems to Study Neurotrophic Factor Effects on Rat Brain Cells (1993) (3)
- Pharmacological Actions of Recombinant Human Nerve Growth Factor on Lesioned Central Cholinergic Neurons: Rationale for the Treatment of Alzheimer’s Disease (1991) (3)
- Effects of Nerve Growth Factor on Cholinergic Neurons of the Rat Forebrain (1985) (2)
- Drug Discovery for Nervous System Diseases (2004) (2)
- Discovery, preclinical development, and clinical trial approach for npt088, a general amyloid interaction motif (GAIM)-immunoglobulin fusion (2015) (2)
- Effects of Brain-Derived Neurotrophic Factor on Injured Dopaminergic Neurons (1994) (1)
- Toxic effects of potential environmental neurotoxins related to MPP+ on cultured rat dopaminergic neurons (1989) (1)
- Neurotransmitters and Neurotrophic Factors (2007) (1)
- Heritability of regional brain volumes in large-scale neuroimaging and genetic studies (2017) (1)
- Neurotrophins and Neurotrophin Receptors in Adult Brain Plasticity (1992) (1)
- Preclinical development of PR006, a gene therapy for the treatment of frontotemporal dementia with progranulin mutations (2020) (1)
- Detrimental actions of neurotrophic agents (1989) (1)
- An enzymatic-istopic method for DOPA and its use for the measurment of dopamine synthesis in rat substantia nigra. (1976) (1)
- An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging (2018) (1)
- F-18 AV-45 (florpiramine F-18): A PET imaging agent for mapping beta-amyloid plaques in the brain (2009) (1)
- Muscarinic receptor-mediated control of hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression (1993) (1)
- Cell Biology of the Forebrain Cholinergic Neurons: Effects of NGF, Triiodothyronine and Gangliosides (1986) (1)
- Potential Pharmacological Use of Neurotrophic Factors in the Treatment of Neurodegenerative Diseases (1989) (1)
- Temporary levodopa withdrawal. (1986) (1)
- Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics (2014) (1)
- Therapeutic Use of Neurotrophic Factors (1995) (0)
- BEAT KNPSEL*t, JOHN W. WINSLOWt, ARNON ROSENTHALt, Louis E. BURTONt, DERICE P. SEID*, (2016) (0)
- Contribution of Cell Culture to Understanding Neuronal Aging and Degeneration (1994) (0)
- A50 RN624 (ANTI-NERVE GROWTH FACTOR ANTIBODY) EFFECTIVELY REDUCES PAIN AND IMPROVES FUNCTION IN SUBJECTSWITH KNEE OSTEOARTHRITIS (2006) (0)
- Manipulation of survival and function of cholinergic neurons by NGF and other neurotrophic factors. Behavioral consequences (1990) (0)
- Contents Vol. 46 (2019) (0)
- Contents Vol. 44, 2017 (2018) (0)
- Gene therapy PR006 increased progranulin levels and improved lysosomal related phenotypes in model systems (2020) (0)
- Postmortem stability of the GABAA receptor complex: a study using rat brain cerebrocortical membranes (1990) (0)
- Use of exploratory INDs in evaluation of 18F-labeled PET amyloid plaque imaging agents (2008) (0)
- Contents Vol.45, 2018 (2018) (0)
- Neurotrophins in the Adult Brain: Effects on Hippocampal Cholinergic Function Following Deafferentation, and Regulation of Their Expression by Pharmacological Agents and Lesions (1993) (0)
- 13 Bridging the Gap between Patients and Models (2015) (0)
- Florpiramine F 18 (AV-45) is an amyloid plaque-selective PET imaging agent (2009) (0)
- The site of decarboxylation of exogenous L-dopa in the rat striatum (1981) (0)
- Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (2020) (0)
- The trend of disruption in the functional brain network topology of Alzheimer’s disease (2021) (0)
- Influence of endogenous and exogenous growth factors on choline-acetyltransferase (ChAT) activity in rats with fimbria-fornix lesions and acetylcholine-rich transplants in the hippocampus (1986) (0)
- Toxicity of Structural Analogs of 1-methyl-4-Phenyl Pyridinium (MPP+) and Related Compounds on Dopaminergic Neurons in Culture (1988) (0)
- Authors' response to commentaries (1989) (0)
- Huntington Chorea: Is It Associated with Hyperactivity of Nigrostriatal Dopaminergic Neurons?: 5—3:30 (1981) (0)
- PR001 gene therapy increased GCase activity and improved Gaucher disease type 1 phenotypes in mouse models (2021) (0)
- Trophic Control of Central Cholinergic Neuron Development In Vitro (1990) (0)
- Elevated BDNF mRNA expression in retinal ganglion cells following optic nerve injury (1996) (0)
- Trophic actions of bdnf on dopaminergic neurons in vitro expression of cell specific proteins and accelerated recovery from mpp toxicity (1991) (0)
- Contents (2019) (0)
- Neurotrophic Factors (1999) (0)
- Neurotrophic Factors (1999) (0)
- F-18 AV-133 as a biomarker for pancreas beta islet cells (2009) (0)
- (262) Acute pain management research in the emergency department - considerations for model development (2008) (0)
- STUDIES ON THE RELEASE OF ENDOGENOUS DOPAMINE FROM SUBCELLULAR PARTICLES DERIVED FROM DENDRITES OF RAT NIGRO-STRIATAL NEURONS (1979) (0)
- Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction (2023) (0)
- Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease (2022) (0)
- NGF and Alzheimer’s disease: a model for trophic factor therapy in neurodegeneration (1994) (0)
- On the pathogenesis of Alzheimer's disease (1986) (0)
- Chronic NGF treatment alters hippocampal muscarinic receptor function in rats with fimbrial transections (1993) (0)
- Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics (2019) (0)
- Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty (2017) (0)
- Chronic dopa feeding of mice (1982) (0)
- Advancing Alzheimer's Diagnosis, Treatment and Care: Recommendations from the Ware Invitational Summit (2013) (0)
- 18F-AV45 dimer: A PET agent for mapping Aβ deposits for cerebral angiopathy (2011) (0)
- Recombinant Human Nerve Growth Factor Increases Presynaptic Cholinergic Function Following Neuronal Damage: Implications for the Treatment of Alzheimer’s Disease (1992) (0)
- IC-P3-205: Development of novel 18F Aβ amyloid imaging agents (2008) (0)
- New clues in the acetaminophen mystery (2005) (0)
- Semi-quantitative visual rating of Florpiramine F 18 (18F-AV -45) PET scans (2009) (0)
- PR001 gene therapy increased GCase activity and improved neuronopathic Gaucher disease phenotypes (2021) (0)
- Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (2020) (0)
- 240) A pharmacokinetic profile of intranasal hydromorphone in emergency room trauma patients (2008) (0)
- Ngf and t 3 increase activity of cholinergic enzymes in cultured septal slices (1987) (0)
- Seizure-Dependent Regulation of BDNF mRNA in the Rat Brain (1992) (0)
- Gene therapy PR001 increased GCase activity and improved neuronopathic Gaucher disease phenotypes in mouse models (2020) (0)
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What Schools Are Affiliated With Franz F. Hefti?
Franz F. Hefti is affiliated with the following schools:
