Fred s. Apple

Fred s. Apple's AcademicInfluence.com Rankings

Fred s. Apple

Medical

#1498

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#1842

Historical Rank

Cardiology

#119

World Rank

#122

Historical Rank

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Medical

Fred s. Apple's Degrees

Doctorate Cardiology Stanford University

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Fred s. Apple's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. (2000) (4196)
Third universal definition of myocardial infarction. (2012) (4123)
Universal definition of myocardial infarction. (2015) (2234)
Cardiac Troponin I A Marker With High Specificity for Cardiac Injury (1993) (1205)
Liberal or restrictive transfusion in high-risk patients after hip surgery. (2011) (1169)
Ferritin: a cytoprotective antioxidant strategem of endothelium. (1992) (1092)
Third universal definition of myocardial infarction. (2012) (751)
Analytical characteristics of high-sensitivity cardiac troponin assays. (2012) (733)
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes. (2007) (720)
National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases. (1999) (707)
Cardiac troponin and outcome in acute heart failure. (2008) (679)
Biomarkers in acute cardiac disease: the present and the future. (2006) (663)
It's time for a change to a troponin standard. (2000) (652)
Predictive Value of Cardiac Troponin I and T for Subsequent Death in End-Stage Renal Disease (2002) (576)
Determination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population. (2012) (523)
Biochemical Mechanisms for Oxygen Free Radical Formation During Exercise (1990) (515)
Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. (2005) (467)
A new season for cardiac troponin assays: it's time to keep a scorecard. (2009) (445)
Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1 (2007) (433)
High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study (2015) (409)
European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: how to use existing assays clinically and for clinical trials. (2002) (400)
Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. American Association for Clinical Chemistry Subcommittee on cTnI Standardization. (1998) (397)
Evaluation of imprecision for cardiac troponin assays at low-range concentrations. (2004) (394)
National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes. (2007) (376)
High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study (2015) (372)
Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations. (2003) (336)
Cardiac troponin-I is not expressed in fetal and healthy or diseased adult human skeletal muscle tissue. (1995) (326)
Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay. (2003) (310)
Characteristics of an Albumin Cobalt Binding Test for assessment of acute coronary syndrome patients: a multicenter study. (2001) (284)
Evidence for functional heterogeneity of circulating B-type natriuretic peptide. (2007) (270)
Cardiac Troponin Assays: Guide to Understanding Analytical Characteristics and Their Impact on Clinical Care. (2017) (270)
National Academy of Clinical Biochemistry laboratory medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure. (2007) (255)
Diseased skeletal muscle: a noncardiac source of increased circulating concentrations of cardiac troponin T. (2011) (252)
Influence of population selection on the 99th percentile reference value for cardiac troponin assays. (2012) (239)
Cardiac troponin I, cardiac troponin T, and creatine kinase MB in dialysis patients without ischemic heart disease: evidence of cardiac troponin T expression in skeletal muscle. (1997) (238)
Multi-biomarker risk stratification of N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and cardiac troponin T and I in end-stage renal disease for all-cause death. (2004) (237)
Bedside Multimarker Testing for Risk Stratification in Chest Pain Units: The Chest Pain Evaluation by Creatine Kinase-MB, Myoglobin, and Troponin I (CHECKMATE) Study (2001) (231)
Cardiac troponin T composition in normal and regenerating human skeletal muscle. (1997) (227)
Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events. (2009) (224)
Quality Specifications for Cardiac Troponin Assays (2001) (218)
IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays. (2015) (218)
Cardiac troponin T isoforms expressed in renal diseased skeletal muscle will not cause false-positive results by the second generation cardiac troponin T assay by Boehringer Mannheim. (1998) (212)
Improved detection of minor ischemic myocardial injury with measurement of serum cardiac troponin I. (1997) (208)
Simultaneous rapid measurement of whole blood myoglobin, creatine kinase MB, and cardiac troponin I by the triage cardiac panel for detection of myocardial infarction. (1999) (207)
High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial (2018) (201)
Definitions for Acute Coronary Heart Disease in Epidemiology and Clinical Research Studies (2003) (194)
Cardiac troponin-T immunoassay for diagnosis of acute myocardial infarction. (1994) (189)
Quality specifications for B-type natriuretic peptide assays. (2005) (187)
Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race. (2002) (185)
Myocardial infarction redefined: role of cardiac troponin testing. (2001) (184)
Use of the Centaur TnI-Ultra assay for detection of myocardial infarction and adverse events in patients presenting with symptoms suggestive of acute coronary syndrome. (2008) (175)
National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical issues for biochemical markers of acute coronary syndromes. (2007) (168)
Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction). (2013) (166)
Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome (2017) (159)
The brain natriuretic peptide (BNP) precursor is the major immunoreactive form of BNP in patients with heart failure. (2007) (156)
The global need to define normality: the 99th percentile value of cardiac troponin. (2014) (154)
High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery. (2013) (153)
Cardiac troponin T alterations in myocardium and serum of rats after stressful, prolonged intense exercise. (2000) (146)
Tissue specificity of cardiac troponin I, cardiac troponin T and creatine kinase-MB. (1999) (145)
Use of Biochemical Markers in Acute Coronary Syndromes. IFCC Scientific Division, Committee on Standardization of Markers of Cardiac Damage (1999) (142)
Supply/demand type 2 myocardial infarction: should we be paying more attention? (2014) (141)
Being rational about (im)precision: a statement from the Biochemistry Subcommittee of the Joint European Society of Cardiology/American College of Cardiology Foundation/American Heart Association/World Heart Federation Task Force for the definition of myocardial infarction. (2010) (140)
Validation of the 99th percentile cutoff independent of assay imprecision (CV) for cardiac troponin monitoring for ruling out myocardial infarction. (2005) (140)
Cardiac troponin I and T alterations in dog hearts with myocardial infarction: correlation with infarct size. (1998) (138)
Effect of sprint cycle training on activities of antioxidant enzymes in human skeletal muscle. (1996) (134)
Cross-reactivity of BNP, NT-proBNP, and proBNP in commercial BNP and NT-proBNP assays: preliminary observations from the IFCC Committee for Standardization of Markers of Cardiac Damage. (2008) (133)
Early diagnostic efficiency of cardiac troponin I and Troponin T for acute myocardial infarction. (1997) (132)
Myocardial tissue troponins T and I. An immunohistochemical study in experimental models of myocardial ischemia. (2003) (130)
Etiology of sudden death in the community: results of anatomical, metabolic, and genetic evaluation. (2010) (130)
Prognostic value of serum cardiac troponin I and T in chronic dialysis patients: a 1-year outcomes analysis. (1997) (127)
RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle. (1999) (126)
Standardization of cardiac troponin I assays: round Robin of ten candidate reference materials. (2001) (116)
Clinical and analytical standardization issues confronting cardiac troponin I. (1999) (115)
Multicenter evaluation of an automated assay for troponin I. (2002) (115)
Implementation of serum cardiac troponin I as marker for detection of acute myocardial infarction. (1999) (114)
Propofol-associated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings. (2000) (114)
Human and canine cardiac troponin T and creatine kinase-MB distribution in normal and diseased myocardium. Infarct sizing using serum profiles. (1995) (112)
Multicenter clinical and analytical evaluation of the AxSYM troponin-I immunoassay to assist in the diagnosis of myocardial infarction. (1999) (112)
Transfusion Trigger Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair (FOCUS) (2006) (109)
National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure. (2008) (108)
Immunodetection of glycosylated NT-proBNP circulating in human blood. (2008) (108)
Effect of population selection on 99th percentile values for a high sensitivity cardiac troponin I and T assays. (2013) (105)
Predictors and outcomes of a perioperative myocardial infarction following elective vascular surgery in patients with documented coronary artery disease: results of the CARP trial. (2008) (104)
Cardiac troponin I measurement with the ACCESS immunoassay system: analytical and clinical performance characteristics. (1998) (102)
Bedside multimarker testing for risk stratification in chest pain units: The chest pain evaluation by creatine kinase-MB, myoglobin, and troponin I (CHECKMATE) study. (2001) (102)
Toward standardization of cardiac troponin I measurements part II: assessing commutability of candidate reference materials and harmonization of cardiac troponin I assays. (2006) (98)
Profile of creatine kinase isoenzymes in skeletal muscles of marathon runners. (1984) (97)
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease. (2012) (97)
High-Sensitivity Cardiac Troponin and the Universal Definition of Myocardial Infarction (2019) (96)
Cardiac troponin and creatine kinase MB monitoring during in-hospital myocardial reinfarction. (2005) (96)
Type 1 and 2 Myocardial Infarction and Myocardial Injury: Clinical Transition to High-Sensitivity Cardiac Troponin I. (2017) (96)
Cardiac biomarkers for detection of myocardial infarction: perspectives from past to present. (2004) (95)
Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome. (2007) (94)
Clinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: user beware. (2012) (92)
Machine Learning to Predict the Likelihood of Acute Myocardial Infarction (2019) (91)
Acute myocardial infarction and coronary reperfusion. Serum cardiac markers for the 1990s. (1992) (91)
Patient selection for high sensitivity cardiac troponin testing and diagnosis of myocardial infarction: prospective cohort study (2017) (90)
Cardiac troponin changes to distinguish type 1 and type 2 myocardial infarction and 180-day mortality risk (2014) (88)
Analytical characteristics of commercial cardiac troponin I and T immunoassays in serum from rats, dogs, and monkeys with induced acute myocardial injury. (2008) (86)
Effect of Neprilysin Inhibition on Various Natriuretic Peptide Assays. (2019) (85)
National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biomarkers of heart failure. (2007) (85)
Time course of serum protein changes after strenuous exercise of the forearm flexors. (1992) (81)
Defining the serum 99th percentile in a normal reference population measured by a high-sensitivity cardiac troponin I assay. (2010) (80)
Creatine kinase isoenzyme activities in men and women following a marathon race. (1985) (79)
[Fourth universal definition of myocardial infarction (2018)]. (2018) (78)
Assessment of the multiple-biomarker approach for diagnosis of myocardial infarction in patients presenting with symptoms suggestive of acute coronary syndrome. (2009) (77)
Counterpoint: Standardization of cardiac troponin I assays will not occur in my lifetime. (2012) (76)
Biochemical markers of cardiac injury in normal, surviving septic, or nonsurviving septic neonatal foals. (2005) (76)
Evaluation of a point-of-care assay for cardiac markers for patients suspected of acute myocardial infarction. (2004) (76)
Analytical performance of the i-STAT cardiac troponin I assay. (2004) (76)
Enzymatic estimation of skeletal muscle damage by analysis of changes in serum creatine kinase. (1988) (74)
Rates of positive cardiac troponin I and creatine kinase MB mass among patients hospitalized for suspected acute coronary syndromes. (2004) (72)
Decreased patient charges following implementation of point-of-care cardiac troponin monitoring in acute coronary syndrome patients in a community hospital cardiology unit. (2006) (70)
National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine practice guidelines: Analytical issues for biomarkers of heart failure. (2008) (70)
Myocardial Injury in the Era of High-Sensitivity Cardiac Troponin Assays: A Practical Approach for Clinicians. (2019) (69)
Diagnosis of type 1 and type 2 myocardial infarction using a high-sensitivity cardiac troponin I assay with sex-specific 99th percentiles based on the third universal definition of myocardial infarction classification system. (2015) (69)
B-type natriuretic peptide (BNP) and N-terminal pro-BNP in obese patients without heart failure: relationship to body mass index and gastric bypass surgery. (2006) (67)
Early monitoring of serum cardiac troponin I for assessment of coronary reperfusion following thrombolytic therapy. (1996) (66)
Results from a multicenter evaluation of the 4th generation Elecsys Troponin T assay. (2007) (65)
Present and Future of Cardiac Troponin in Clinical Practice: A Paradigm Shift to High-Sensitivity Assays. (2016) (63)
Myocardial Infarction Risk Stratification With a Single Measurement of High-Sensitivity Troponin I. (2019) (63)
High-sensitivity cardiac troponin assays for cardiovascular risk stratification in the general population. (2020) (63)
Methadone-related deaths in Hennepin County, Minnesota: 1992-2002. (2003) (62)
Cardiac isoenzymes in healthy Holstein calves and calves with experimentally induced endotoxemia. (2008) (60)
Increased cardiac troponin I as measured by a high-sensitivity assay is associated with high odds of cardiovascular death: the Minnesota Heart Survey. (2012) (60)
A translational approach to detecting drug-induced cardiac injury with cardiac troponins: consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute. (2009) (59)
Sex-Specific 99th Percentile Upper Reference Limits for High Sensitivity Cardiac Troponin Assays Derived Using a Universal Sample Bank. (2020) (58)
Postmortem redistribution of fentanyl in blood. (2010) (58)
Point-of-care i-STAT cardiac troponin I for assessment of patients with symptoms suggestive of acute coronary syndrome. (2006) (58)
High sensitivity, contemporary and point-of-care cardiac troponin assays: educational aids developed by the IFCC Committee on Clinical Application of Cardiac Bio-Markers (2019) (57)
Poor iron status of women runners training for a marathon. (1986) (57)
International survey on the use of cardiac markers. (2001) (56)
Cardiac troponin I and T alterations in hearts with severe left ventricular remodeling. (1997) (56)
Variations in vitreous humor chemical values as a result of instrumentation. (1985) (56)
Specificity of B-Type Natriuretic Peptide Assays: Cross-Reactivity with Different BNP, NT-proBNP, and proBNP Peptides. (2017) (56)
Misleading hyponatremia due to hyperlipemia: a method-dependent error. (1981) (55)
Cardiac troponin assays: a review of quantitative point-of-care devices and their efficacy in the diagnosis of myocardial infarction (2015) (55)
Cocaine, cocaine metabolite, and ethanol concentrations in postmortem blood and vitreous humor. (2000) (55)
Evidence-based implementation of free phenytoin therapeutic drug monitoring. (2000) (54)
Mitochondrial creatine kinase activity alterations in skeletal muscle during long-distance running. (1986) (54)
Analysis of the Albumin cobalt Binding (ACBTM) test as an adjunct to cardiac troponin I for the early detection of acute myocardial infarction (2007) (53)
Measurement of chemical analytes in vitreous humor: stability and precision studies. (2004) (53)
The applied statistical approach highly influences the 99th percentile of cardiac troponin I. (2016) (52)
Creatinine clearance: enzymatic vs Jaffé determinations of creatinine in plasma and urine. (1986) (51)
Clinical evaluation of the first medical whole blood, point-of-care testing device for detection of myocardial infarction. (2000) (51)
Renal Dysfunction Influences the Diagnostic and Prognostic Performance of High-Sensitivity Cardiac Troponin I. (2017) (51)
Creatine kinase isoenzyme MM variants in skeletal muscle and plasma from marathon runners. (1986) (51)
Comparison of serum creatine kinase and creatine kinase MB activities post marathon race versus post myocardial infarction. (1984) (50)
Lipase and pancreatic amylase activities in tissues and in patients with hyperamylasemia. (1991) (50)
Early detection of skeletal muscle injury by assay of creatine kinase MM isoforms in serum after acute exercise. (1988) (50)
Sodium measurements in multiple myeloma: two techniques compared. (1982) (49)
Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays (2014) (49)
Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays (2014) (49)
Relationship between blood alcohol concentration and observable symptoms of intoxication in patients presenting to an emergency department. (2013) (49)
Improving Prediction of Postoperative Myocardial Infarction With High-Sensitivity Cardiac Troponin T and NT-proBNP (2017) (48)
How Well Do Laboratories Adhere to Recommended Clinical Guidelines for the Management of Myocardial Infarction: The CARdiac MArker Guidelines Uptake in Europe Study (CARMAGUE). (2016) (48)
Serum and plasma cardiac troponin I 99th percentile reference values for 3 2nd-generation assays. (2007) (48)
Serum enzyme changes during marathon training. (1983) (48)
Liver and blood postmortem tricyclic antidepressant concentrations. (1988) (48)
Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects. (1999) (48)
Single High-Sensitivity Cardiac Troponin I to Rule Out Acute Myocardial Infarction. (2017) (48)
Proposals from IFCC Committee on Standardization of Markers of Cardiac Damage (C-SMCD): recommendations on use of biochemical markers of cardiac damage in acute coronary syndromes. (1999) (47)
High-sensitivity cardiac troponin: hype, help, and reality. (2010) (46)
Rapid Rule-Out of Acute Myocardial Injury Using a Single High-Sensitivity Cardiac Troponin I Measurement. (2017) (45)
High-sensitivity cardiac troponin assays and unstable angina (2018) (45)
CK and LD isozymes in human single muscle fibers in trained athletes. (1989) (44)
Proposals from the IFCC Committee on Standardization of Markers of Cardiac Damage (C-SMCD): strategies and concepts on standardization of cardiac marker assays. (1999) (44)
Diagnostic performance of four point of care cardiac troponin I assays to rule in and rule out acute myocardial infarction. (2013) (44)
Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research (2016) (44)
Why all the struggle about CK-MB and PCI? (2012) (44)
Creatine kinase-MB isoenzyme adaptations in stressed human skeletal muscle of marathon runners. (1984) (43)
Relationship between direct-potentiometric and flame-photometric measurement of sodium in blood. (1982) (43)
Cardiac troponin, CK-MB and myoglobin for the early detection of acute myocardial infarction and monitoring of reperfusion following thrombolytic therapy. (1995) (43)
Postmortem tricyclic antidepressant concentrations: assessing cause of death using parent drug to metabolite ratio. (1989) (42)
Prognostic Value of Serial Changes in High-Sensitivity Cardiac Troponin I and T over 3 Months Using Reference Change Values in Hemodialysis Patients. (2016) (42)
Prevention of analytical false-positive increases of cardiac troponin I on the Stratus II analyzer. (1997) (42)
The Specificity of Biochemical Markers of Cardiac Damage: a Problem Solved (1999) (42)
Creatine kinase-MB isoenzyme adaptations in stressed human skeletal muscle of marathon runners (1985) (42)
Optimum blood collection intervals for B-type natriuretic peptide testing in patients with heart failure. (2004) (41)
Cardiac troponin I and creatine kinase-MB mass to rule out myocardial injury in hospitalized patients with renal insufficiency. (1998) (40)
Serum 99th percentile reference cutoffs for seven cardiac troponin assays. (2004) (40)
Creatine kinase isoforms following isometric exercise (1987) (40)
Discordance between ICD-Coded Myocardial Infarction and Diagnosis according to the Universal Definition of Myocardial Infarction. (2017) (40)
Assessment of left ventricular function using serum cardiac troponin I measurements following myocardial infarction. (1998) (39)
Analyses of creatine kinase isoenzymes and isoforms in serum to detect reperfusion after acute myocardial infarction. (1987) (38)
Diagnostic Performance of High Sensitivity Compared with Contemporary Cardiac Troponin I for the Diagnosis of Acute Myocardial Infarction. (2017) (38)
Total Analytic Error for Low Cardiac Troponin Concentrations (≤10 ng/L) by Use of a High-Sensitivity Cardiac Troponin Assay. (2017) (38)
Expression of cardiac troponin T isoforms in skeletal muscle of renal disease patients will not cause false-positive serum results by the second generation cardiac troponin T assay. (1998) (37)
Bovine polymerized hemoglobin (hemoglobin-based oxygen carrier-201) resuscitation in three swine models of hemorrhagic shock with militarily relevant delayed evacuation—Effects on histopathology and organ function* (2006) (37)
Outcomes of hospitalized patients with non-acute coronary syndrome and elevated cardiac troponin level. (2011) (37)
Novel immunoassay for quantification of brain natriuretic peptide and its precursor in human blood. (2008) (37)
Performance characteristics of the ARCHITECT Galectin-3 assay. (2013) (36)
Cardiac troponin testing in the acute care setting: ordering, reporting, and high sensitivity assays--an update from the Canadian society of clinical chemists (CSCC). (2011) (36)
Incidence of Undetectable, Measurable, and Increased Cardiac Troponin I Concentrations Above the 99th Percentile Using a High-Sensitivity vs a Contemporary Assay in Patients Presenting to the Emergency Department. (2016) (35)
Delta changes for optimizing clinical specificity and 60-day risk of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome utilizing the ADVIA Centaur TnI-Ultra assay. (2012) (35)
Performance of Novel High-Sensitivity Cardiac Troponin I Assays for 0/1-Hour and 0/2- to 3-Hour Evaluations for Acute Myocardial Infarction: Results From the HIGH-US Study. (2020) (35)
Cardiac Troponin I and T Concentrations in Patients with Cocaine-Associated Chest Pain (1996) (35)
Fentanyl postmortem redistribution: preliminary findings regarding the relationship among femoral blood and liver and heart tissue concentrations. (2008) (35)
N-terminal and C-terminal fragments of IGFBP-4 as novel biomarkers for short-term risk assessment of major adverse cardiac events in patients presenting with ischemia. (2012) (34)
Cardiac Biomarkers (2015) (33)
Longitudinal studies of cardiac troponin I in a large cohort of healthy children. (2012) (33)
Expression of creative kinase M and B mRNAs in treadmill trained rat skeletal muscle (1994) (31)
Iron status of active women and the effect of running a marathon on bowel function and gastrointestinal blood loss. (1991) (29)
Clinical and analytical review of ischemia-modified albumin measured by the albumin cobalt binding test. (2005) (28)
Assessment of the diagnostic accuracy of the TDx-FLM II to predict fetal lung maturity. (2002) (27)
Delta cardiac troponin values in practice: are we ready to move absolutely forward to clinical routine? (2012) (27)
Skeletal muscle lactate dehydrogenase isozyme alterations in men and women marathon runners. (1986) (27)
Cardiac troponin T is not detected in Western blots of diseased renal tissue. (2001) (26)
Placental growth factor and B-type natriuretic peptide as independent predictors of risk from a multibiomarker panel in suspected acute coronary syndrome (Acute Risk and Related Outcomes Assessed With Cardiac Biomarkers [ARROW]) study. (2011) (26)
Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB) (2019) (26)
Marathoner's heart? (2006) (26)
Use of the bioMérieux VIDAS troponin I ultra assay for the diagnosis of myocardial infarction and detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome. (2008) (26)
Sex-specific 99th percentiles derived from the AACC Universal Sample Bank for the Roche Gen 5 cTnT assay: Comorbidities and statistical methods influence derivation of reference limits. (2017) (25)
Effectiveness of practices for improving the diagnostic accuracy of Non ST Elevation Myocardial Infarction in the Emergency Department: A Laboratory Medicine Best Practices™ systematic review. (2015) (25)
Central versus local adjudication of myocardial infarction in a cardiac biomarker trial. (2013) (24)
Unbound free fatty acid concentrations are increased in cardiac ischemia (2004) (24)
Prognostic value of the Ortho Vitros cardiac troponin I assay in patients with symptoms of myocardial ischemia. Risk stratification using European Society of Cardiology/American College of Cardiology recommended cutoff values. (2003) (24)
Postmortem blood free and total morphine concentrations in medical examiner cases. (2001) (24)
High-sensitivity cardiac troponin assays: isn't it time for equality? (2014) (24)
False-positive AxSYM cardiac troponin I results in a 53-year-old woman. (2002) (24)
High-Sensitivity Cardiac Troponin on Presentation to Rule Out Myocardial Infarction (2021) (23)
Diagnostic use of CK-MM and CK-MB isoforms for detecting myocardial infarction. (1989) (23)
Use of objective evidence of myocardial ischemia to facilitate the diagnostic and prognostic distinction between type 2 myocardial infarction and myocardial injury (2018) (23)
Monitoring plasma cardiac troponin I for the detection of myocardial injury after percutaneous transluminal coronary angioplasty. (2000) (22)
Use of the HEART Pathway with high sensitivity cardiac troponins: A secondary analysis. (2017) (22)
Clinical and analytical evaluation of two immunoassays for direct measurement of creatine kinase MB with monoclonal anti-CK-MB antibodies. (1988) (22)
Multi-center validation of the Response Biomedical Corporation RAMP NT-proBNP assay with comparison to the Roche Diagnostics GmbH Elecsys proBNP assay. (2007) (22)
High-sensitivity cardiac troponin for screening large populations of healthy people: is there risk? (2011) (22)
Expression of creatine kinase M and B mRNAs in treadmill trained rat skeletal muscle. (1994) (22)
Unraveling N-terminal pro-B-type natriuretic peptide: another piece to a very complex puzzle in heart failure patients. (2015) (21)
Multiple biomarkers including cardiac troponins T and I measured by high-sensitivity assays, as predictors of long-term mortality in patients with chronic renal failure who underwent dialysis. (2015) (21)
The state of cardiac troponin assays: looking bright and moving in the right direction. (2013) (21)
Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats. (2013) (21)
Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction (2020) (20)
Myeloperoxidase improves risk stratification in patients with ischemia and normal cardiac troponin I concentrations. (2011) (20)
Post-infarction left ventricular remodeling induces changes in creatine kinase mRNA and protein subunit levels in porcine myocardium. (1997) (20)
Free oxycodone concentrations in 67 postmortem cases from the Hennepin County medical examiner's office. (2008) (20)
Men are different than women: it's true for cardiac troponin too. (2014) (19)
The third Universal Definition of Myocardial Infarction--moving forward. (2012) (19)
Canine myocardial creatine kinase isoenzyme response to coronary artery occlusion. (1989) (19)
Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results (2020) (19)
High-Sensitivity Cardiac Troponin T Improves the Diagnosis of Perioperative MI (2017) (19)
Assessment of renal function by inulin clearance: comparison with creatinine clearance as determined by enzymatic methods. (1989) (19)
Preliminary evaluation of the Vitros ECi cardiac troponin I assay. (2000) (19)
Superiority of postmortem liver fentanyl concentrations over peripheral blood influenced by postmortem interval for determination of fentanyl toxicity. (2013) (19)
The diagnostic utility of cardiac biomarkers in detecting myocardial infarction. (2005) (19)
Susceptibility of Cardiac Troponin Assays to Biotin Interference (2019) (19)
The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity (2016) (18)
Skeletal muscle creatine kinase MB alterations in women marathon runners (2004) (18)
Cardiac Troponin Thresholds and Kinetics to Differentiate Myocardial Injury and Myocardial Infarction (2021) (18)
Early kinetic profiles of troponin I and T measured by high-sensitivity assays in patients with myocardial infarction. (2020) (18)
High-Sensitivity Cardiac Troponin Assays: What Analytical and Clinical Issues Need to Be Addressed before Introduction into Clinical Practice? (2010) (18)
The IFCC Clinical Application of Cardiac Biomarkers Committee's Appraisal of the 2020 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation: Getting Cardiac Troponin Right. (2020) (18)
Clinical Features and Outcomes of Emergency Department Patients With High-Sensitivity Cardiac Troponin I Concentrations Within Sex-Specific Reference Intervals. (2019) (17)
Cocaine-associated fetal death in utero. (1990) (17)
Standardization of immunoassays for measurement of myoglobin in serum. Phase I: evaluation of candidate secondary reference materials. (2004) (17)
Financial impact of a rapid CK-MB-specific immunoassay on the diagnosis of myocardial infarction. (1990) (17)
Educational Recommendations on Selected Analytical and Clinical Aspects of Natriuretic Peptides with a Focus on Heart Failure: A Report from the IFCC Committee on Clinical Applications of Cardiac Biomarkers. (2019) (17)
Creation of a Universal Sample Bank for Determining the 99th Percentile for Cardiac Troponin Assays. (2017) (17)
High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women (2016) (17)
Improving the 510(k) FDA process for cardiac troponin assays: in search of common ground. (2014) (16)
High-Sensitivity Cardiac Troponin on Presentation to Rule Out Myocardial Infarction A Stepped-Wedge Cluster Randomized Controlled Trial (2021) (16)
Operationalizing cardiac troponin I testing along ESC/ACC consensus guidelines for defining myocardial infarction: increasing rate of detection. (2003) (16)
Geographic distribution of xanthine oxidase, free radical scavengers, creatine kinase, and lactate dehydrogenase enzyme systems in rat heart and skeletal muscle. (1991) (16)
Searching for a BNP standard: Glycosylated proBNP as a common calibrator enables improved comparability of commercial BNP immunoassays. (2017) (16)
Alterations in the expression and activity of creatine kinase-M and mitochondrial creatine kinase subunits in skeletal muscle following prolonged intense exercise in rats (2000) (16)
Creatine kinase isoforms and myoglobin: early detection of myocardial infarction and reperfusion. (1999) (16)
Ischemia Modified Albumin Measured by the Albumin Cobalt Binding Test: A Clinical and Analytical Review (2004) (15)
Early peak of creatine kinase-MB in acute myocardial infarction with a nondiagnostic electrocardiogram. (1988) (15)
Accident or arson: is CO-oximetry reliable for carboxyhemoglobin measurement postmortem? (2010) (15)
New Blood Tests for Detecting Heart Disease (2004) (15)
Biochemical markers of thrombolytic success (1999) (15)
Outcome of low-risk patients discharged home after a normal cardiac troponin I. (2004) (15)
Performance characteristics of the Architect brain natriuretic peptide (BNP) assay: a two site study. (2008) (15)
False-positive lysergic acid diethylamide immunoassay screen associated with fentanyl medication. (2002) (15)
Why we don't know the answer may be more important than the specific question. (2004) (15)
Risk Estimation in Type 2 Myocardial Infarction and Myocardial Injury: The TARRACO Risk Score. (2019) (14)
Electronic medical record-based performance improvement project to document and reduce excessive cardiac troponin testing. (2015) (14)
Diagnostic and prognostic value of cardiac troponin I assays in patients admitted with symptoms suggestive of acute coronary syndrome. (2004) (14)
Rapid, robust, and sustainable antibody responses to mRNA COVID-19 vaccine in convalescent COVID-19 individuals (2021) (14)
99th Percentile Upper-Reference Limit of Cardiac Troponin and the Diagnosis of Acute Myocardial Infarction. (2020) (14)
Standardization of Cardiac Markers (2005) (13)
Near-bedside whole-blood cardiac troponin I assay for risk assessment of patients with acute coronary syndromes. (2002) (13)
Cardiac troponin assays (2007) (13)
Analytical issues for cardiac troponin. (2004) (13)
Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts (2020) (13)
Early serum cardiac troponin I and T concentrations after successful thrombolysis for acute myocardial infarction. (1995) (13)
Cardiovascular Disease: Impact of Biomarkers, Proteomics, and Genomics. (2017) (12)
Cardiac troponin monitoring for detection of myocardial infarction: newer generation assays are here to stay. (2007) (12)
102 Diagnosis of Type I versus Type II Myocardial Infarction in Emergency Department Patients With Ischemic Symptoms (2011) (12)
Loss of myocardial CK-MB into the circulation following 3.5 hours of swimming in a rat model. (2000) (12)
Serial sampling of copeptin levels improves diagnosis and risk stratification in patients presenting with chest pain: results from the CHOPIN trial (2015) (12)
National academy of clinical biochemistry laboratory medicine practice guidelines: Point of care testing, oversight, and administration of cardiac biomarkers for acute coronary syndromes (2007) (12)
Measurement of B-type natriuretic peptide by two assays utilizing antibodies with different epitope specificity. (2011) (12)
The use of biochemical markers in ischaemic heart disease: summary of the roundtable and extrapolations. (1998) (12)
Abstract 2065: Multiple Biomarker Utilization for Detection of Adverse Events in Patients Presenting With Symptoms Suggestive of Acute Coronary Syndrome: Influence of eGFR (2006) (12)
Serum cardiac troponin T concentrations in hospitalized patients without acute myocardial infarction. (1996) (11)
A better understanding of the interpretation of postmortem blood drug concentrations. (2011) (11)
Clinical implementation of a rapid, automated assay for assessing fetal lung maturity. (1994) (11)
Elevation of creatine kinase BB CK in hospitalized patients. Importance of distinguishing BB CK from MB CK. (1982) (10)
Presence of creatine kinase MB isoenzyme during marathon training. (1981) (10)
Type 2 myocardial infarction. Potential hazards of nomenclature systems: user discretion advised. (2015) (10)
Determination of sex-specific 99th percentile upper reference limits for a point of care high sensitivity cardiac troponin I assay (2021) (10)
Trial design for assessing analytical and clinical performance of high-sensitivity cardiac troponin I assays in the United States: The HIGH-US study (2019) (10)
Chromatographic behavior of immunoglobulin-bound creatine kinase on DEAE-Sephadex A-50. (1984) (10)
Glycogen phosphorylase BB and other cardiac proteins: challenges to creatine kinase MB as the marker for detecting myocardial injury. (1995) (10)
Kinetic characterization of human heart and skeletal muscle CK isoenzymes. (1988) (10)
How low can we go? The high-sensitivity cardiac troponin debate. (2013) (9)
BNP test utilization for CHF in community hospital practice. (2003) (9)
Midregional proadrenomedullin predicts mortality and major adverse cardiac events in patients presenting with chest pain: results from the CHOPIN trial. (2015) (9)
Propylene glycol interference in gas-chromatographic assay of ethylene glycol. (1993) (9)
Cardiac troponin risk stratification based on 99th percentile reference cutoffs in patients with ischemic symptoms suggestive of acute coronary syndrome: influence of estimated glomerular filtration rates. (2007) (9)
The changing face of laboratory medicine: a more service and less academically oriented profession? (2015) (8)
Refining our criteria: a critical challenge. (2009) (8)
Analytical Considerations in Deriving 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin Assays: Educational Recommendations from the IFCC Committee on Clinical Application of Cardiac Bio-Markers. (2022) (8)
Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury. (2017) (8)
Independent and combined effects of biotin and hemolysis on high-sensitivity cardiac troponin assays (2021) (8)
Type 2 myocardial infarction: the next frontier. (2014) (8)
Impact of biomarkers, proteomics, and genomics in cardiovascular disease. (2012) (8)
ROLE OF DELTA CARDIAC TROPONIN I TO DISTINGUISH BETWEEN TYPE I NSTEMI AND TYPE II MYOCARDIAL INFARCTION (2013) (7)
TNF-alpha effect on oxygen free radical scavenging and generating enzymes in rat liver. (1994) (7)
Cardiac troponin: redefining the detection of myocardial infarction. (2002) (7)
Sex-Specific Kinetics of High-Sensitivity Cardiac Troponin I and T following Symptom Onset and Early Presentation in Non-ST-Segment Elevation Myocardial Infarction. (2020) (7)
Predicting respiratory distress syndrome using gestational age and lamellar body count. (2013) (7)
Analytical and clinical performance of the Ortho-Clinical Diagnostics VITROS amino-terminal pro-B type natriuretic peptide assay. (2008) (7)
Multicenter assessment of a hemoglobin A1c point-of-care device for diagnosis of diabetes mellitus. (2018) (7)
A Noncardiac Source of Increased Circulating Concentrations of Cardiac Troponin T (2011) (7)
Macrotroponin Complex as a Cause for Cardiac Troponin Increase after COVID-19 Vaccination and Infection (2022) (6)
Markers in cardiology : a case-oriented approach (2007) (6)
Cardiac troponin testing is overused after the rule-in or rule-out of myocardial infarction. (2015) (6)
Copeptin to rule out myocardial infarction in Blacks versus Caucasians (2019) (6)
Urine Creatinine Concentrations in Drug Monitoring Participants and Hospitalized Patients. (2016) (6)
Evidence of myocardial infarction in mummified human tissue. (2000) (6)
Factitiously high sodium activities on the Ektachem 400 owing to interferences by high gamma-globulin concentrations. (1989) (6)
The creatine kinase system in the serum of runners following a doubling of training mileage. (1992) (6)
Appropriateness of Cardiac Troponin Testing: Insights from the Use of TROPonin In Acute coronary syndromes (UTROPIA) Study. (2019) (6)
Comparison of 0/3-Hour Rapid Rule-Out Strategies Using High-Sensitivity Cardiac Troponin I in a US Emergency Department (2020) (5)
Clinical use of cardiac troponin for acute cardiac care and emerging opportunities in the outpatient setting. (2019) (5)
Necessity of hospitalization and stress testing in low risk chest pain patients (2017) (5)
Does increased lipase activity in serum imply damage to the pancreas? (1992) (5)
Labetalol: false-positive indices by EMIT-d.a.u. assay and Toxi-Lab A urine screen. (1985) (5)
Serum and muscle alanine aminotransferase activities in marathon runners. (1984) (5)
High-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain (2022) (5)
Science Moves Slowly. (2018) (5)
Does low total creatine kinase rule out myocardial infarction? (1992) (5)
High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study (2015) (5)
Serum thiocyanate concentrations in patients with normal or impaired renal function receiving nitroprusside. (1996) (5)
Clinical evaluation of the Alpha Dx cardiac panel for total CK mass, CK MB mass, cardiac troponin I, and myoglobin for detection of acute myocardial infarction (1998) (5)
The new face of heroin. (2017) (5)
Validation of the myocardial-ischaemic-injury-index machine learning algorithm to guide the diagnosis of myocardial infarction in a heterogenous population: a prespecified exploratory analysis (2022) (5)
The challenges and concerns companies face pertaining to the US Food and Drug Administration 510(k) process for cardiac biomarkers. (2012) (5)
Biochemical markers of thrombolytic success. IFCC Committee on Standardization of Markers of Cardiac Damage. (1999) (5)
Creatine Kinase-MB (1992) (4)
Standards of Laboratory Practice : Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases (1999) (4)
No increase in the incidence of cardiac troponin i concentration above the 99th percentile by siemens centaur high-sensitivity compared to the contemporary assay. (2020) (4)
Cardiac Troponin in Conditions Other Than Acute Coronary Syndromes (2006) (4)
SKELETAL MUSCLE LACTATE DEHYDROGENASE ISOENZYME ALTERATIONS IN MARATHON RUNNERS (1986) (4)
High-Sensitivity Cardiac Troponin T in Prediction and Diagnosis of Myocardial Infarction and Long-Term Mortality after Non-Cardiac Surgery (2013) (4)
Glycerol interference in serum lipase assay falsely indicates pancreas injury. (1992) (4)
The utility of risk scores when evaluating for acute myocardial infarction using high-sensitivity cardiac troponin I. (2020) (4)
Biomarkers in aggregate (2011) (4)
Edging closer to early optimal patient management with high-sensitivity cardiac troponin assay. (2011) (3)
COMPARISON OF ELEVATED SERUM CREATINE KINASE MB ACTIVITIES POST MARATHON AND POST MYOCARDIAL INFARCTION (1983) (3)
Endurance Exercise Training Attenuates Natriuretic Peptide Release During Maximal Effort Exercise: Biochemical Correlates of the "Athlete's Heart". (2018) (3)
Brain Natriuretic Peptide in the Diagnosis and Management of Congestive Heart Failure (2002) (3)
Incidence and Prognostic Impact of Infection in Patients with Type 1 and 2 Myocardial Infarction. (2020) (3)
Multicenter analytical evaluation of an automated immunoassay for total plasma homocysteine. (2000) (3)
Finding acute coronary syndrome with serial troponin testing for rapid assessment of cardiac ischemic symptoms (FAST-TRAC): a study protocol (2022) (3)
Use of troponins in clinical practice: Evidence in favour of use of troponins in clinical practice (2019) (3)
Incorporating high-sensitivity cardiac troponin assays into clinical practice: These assays are your friend (2015) (3)
Serum creatinine concentration and the discrepancy between enzyme multiplied immunoassay technique and gas-liquid chromatographic phenytoin levels. (1983) (3)
Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction. (2020) (3)
Another reader comments on the same article (1998) (3)
In Reply. (2017) (3)
Diagnostic Markers for Detection of Acute Myocardial Infarction and Reperfusion (1992) (3)
Cardiac Troponin Testing in Renal Failure and Skeletal Muscle Disease Patients (2003) (3)
Letter by Sandoval et al Regarding Article, "Designing a Better Mousetrap: Reflections on the November 28, 2017, US Food and Drug Administration Meeting on Next-Generation "High-Sensitivity" Cardiac Troponin Assays to Diagnose Myocardial Infarction". (2019) (3)
Lot-to-Lot Variation for Commercial High-Sensitivity Cardiac Troponin: Can We Realistically Report Down to the Assay's Limit of Detection? (2020) (3)
Cardiac Troponin Testing for Detection of Myocardial Infarction (2003) (3)
EFFECTS OF MODERATE IRON SUPPLEMENTATION ON THE IRON STATUS OF RUNNERS WITH LOW SERUM FERRITIN CONCENTRATIONS (1986) (3)
High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome (2016) (3)
Cardiology patient page. New blood tests for detecting heart disease. (2004) (3)
Letter regarding article by Khan et al, "prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis". (2006) (3)
Value of Soluble Markers in the Diagnosis of Reperfusion after Thrombolysis (1998) (3)
Lower diagnostic accuracy of hs-cTnI in patients with prior coronary artery bypass grafting. (2022) (2)
EFFECTS OF PROLONGED HIGH INTENSITY RUNNING ON MYOCARDIUM IN UNTRAINED RATS 1401 (1997) (2)
Let's talk about change, cardiac troponin deltas: a step in the right direction. (2013) (2)
High-sensitivity cardiac troponin on presentation to rule out myocardial infarction: a stepped-wedge cluster randomised controlled trial (2020) (2)
Reply to letter by Trupp et al. (2017) (2)
High-Sensitivity Cardiac Troponin and the Diagnosis of Myocardial Infarction in Patients with Renal Impairment. (2022) (2)
Skeletal muscle expression of creatine kinase-B in end-stage renal disease (2004) (2)
Falsely increased CK-MB results obtained with the new reformulated CK-MB wash IV solution in the Stratus analyzer. (1990) (2)
High-sensitivity troponin i: One-hour evaluation for acute myocardial infarction in the United States (2019) (2)
Clinical Biomarkers of Cardiac Injury: Cardiac Troponins and Natriuretic Peptides (2006) (2)
Role of BNP vs NT-proBNP Testing in the Age of New Drug Therapies: Sacubitril-Valsartan. (2019) (2)
Elevated serum ferritin concentrations in master runners after a marathon race. (1986) (2)
Outpatient versus Observation/Inpatient Management of Emergency Department Patients Rapidly Ruled-out for Acute Myocardial Infarction: Findings from the HIGH-US Study. (2020) (2)
Rapid Identification of Patients at High Risk for Acute Myocardial Infarction Using a Single High-Sensitivity Cardiac Troponin I Measurement. (2020) (2)
More rapid, robust and sustainable antibody responses to mRNA COVID-19 vaccine in convalescent COVID-19 individuals (2021) (2)
Point-of-Care Cardiac Troponin Testing: Process Improvements for Detection of Acute Myocardial Infarction (2006) (2)
CREATINE KINASE ISOENZYME ELEVATIONS AND CLEARANCE RATES IN MEN AND WOMEN FOLLOWING A 42.2 KM RACE (1984) (2)
Single High-Sensitivity Point-of-Care Whole-Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk (2022) (2)
Diagnostic Performance of a Rapid, Novel, Whole Blood, Point of Care High-Sensitivity Cardiac Troponin I Assay for Myocardial Infarction. (2022) (2)
Performance characteristics of a new myoglobin microparticle enzyme immunoassay: a multicenter evaluation. (2000) (2)
Increased concentrations of cardiac troponin I are equivalent to increased cardiac troponin T in identifying chest pain patients at short-term risk of myocardial infarction. (1998) (2)
Ongoing Challenges with Type 2 Myocardial Infarction. (2016) (2)
Should we monitor troponin up to peak value when evaluating for acute coronary syndrome? (2020) (2)
Is troponin I a risk factor for poor outcome in pulmonary embolism (2002) (1)
The effect of 1.6 km, 5 km, 10 km, 25 km and 42.2 km races on serum creatine kinase in male and female runners (1987) (1)
Implementation of High-Sensitivity Cardiac Troponin Assays in the United States. (2022) (1)
Cardiac troponin measurement at the point of care: educational recommendations on analytical and clinical aspects by the IFCC Committee on Clinical Applications of Cardiac Bio-Markers (IFCC C-CB) (2023) (1)
Serum creatine kinase isoenzyme measurements in master male and female marathon runners (1992) (1)
Low pO2 Contributes to Potential Error in Oxygen Saturation Calculations Using a Point-of-Care Assay (2017) (1)
PERFORMANCE OF A NOVEL HIGH SENSITIVITY CARDIAC TROPONIN I ASSAY FOR A ONE HOUR ALGORITHM FOR EVALUATION OF NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION IN THE UNITED STATES (2019) (1)
Biomarker Testing Considerations in the Evaluation and Management of Patients with Heart Failure: Perspectives from the International Federation of Clinical Chemistry and Laboratory Medicine Committee. (2021) (1)
Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome (2022) (1)
Analytical Performance Comparing Siemens Whole Blood Point of Care Atellica VTLi to the Central Laboratory Plasma Atellica IM High-Sensitivity Cardiac Troponin I Assays. (2023) (1)
Postmortem Redistribution of Drugs (2020) (1)
A comparison of modelled serum cTnT and cTnI kinetics after 60 min swimming (2022) (1)
The authors of the article cited above respond (2006) (1)
Excellence in acute cardiac care: an overview of the seminar proceedings (2014) (1)
RISK STRATIFICATION OF CHEST PAIN IN THE EMERGENCY DEPARTMENT: INCORPORATING A HIGH-SENSITIVITY TROPONIN ASSAY INTO EXISTING RISK TOOLS (2019) (1)
5 Adverse Outcomes 30 Days After Emergency Department Evaluation for Myocardial Infarction Determined Solely by High Sensitivity Troponin I Values for a 1-Hour Rule-Out/Rule-In Acute Myocardial Infarction Algorithm (2019) (1)
Use of B-type natriuretic peptide testing in a community teaching hospital 4 years after implementation and agreement of results with discharge diagnoses. (2006) (1)
743 ANTIOXIDANT ENZYME ACTIVITIES IN RAT SKELETAL MUSCLES: EFFECTS OF ATROPHY, VITAMIN E, & EXERCISE (1994) (1)
CHRONIC ENZYME ELEVATION DURING MARATHON TRAINING (1982) (1)
3: Comparison of Point-of-Care and Central Laboratory Methods for the Measurement of Cardiac Troponin I in Patients With Suspected Acute Myocardial Infarction (2015) (1)
COPEPTIN PROVIDES PROGNOSTIC VALUE IN PATIENTS WITH ACUTE CHEST PAIN (2014) (1)
Upper Reference limits and percent measurable concentrations using a universal sample bank for high sensitivity cardiac troponin I using a point-of-care assay. (2020) (1)
Rates of diagnosis of acute myocardial infarction utilizing cardiac troponin-I or creatine kinase MB (2003) (1)
RAPID RULE OUT OF MYOCARDIAL INJURY USING A SINGLE HIGH-SENSITIVITY CARDIAC TROPONIN I MEASUREMENT (2016) (1)
Improving the 510k FDA Process for Cardiac Troponin Assays: In Search of Common Ground (2014) (1)
Brain energy stores in C57BL/6 mice after C. parvum injection. (1999) (1)
Abstract 17337: Multiple Biomarkers for the Prediction of Cardiovascular Death Within the Minnesota Heart Survey (2010) (1)
Diagnosis And Management Of Congestive Heart Failure (2002) (1)
How Well Do Laboratories Adhere to Recommended Guidelines for Cardiac Biomarkers Management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) Study of the European Federation of Laboratory Medicine Task Group on Cardiac Markers. (2021) (1)
Genetic predisposition to cardiovascular disease potentiates delayed doxorubicin cardiotoxicity during pregnancy (2006) (1)
Guidelines: Clinical Utilization of Cardiac Biomarker Testing in Heart Failure National Academy of Clinical Biochemistry Laboratory Medicine Practice (2008) (1)
Caveat emptor – hidden pitfalls in defining the 99th percentile of cardiac troponin assays (2021) (1)
Laboratory findings in a child with SARS-CoV-2 (COVID-19) multisystem inflammatory syndrome (2021) (1)
Biomarkers in Cardiovascular Disease: Utility in Diagnosis, Risk Assessment, and Therapy. (2021) (1)
Drs. Wu and Apple respond (2002) (1)
219 DELAY IN SERUM PROTEIN CHANGES AFTER ECCENTRIC EXERCISE (1990) (1)
Practice Guidelines : Use of Cardiac Troponin and B-Type Natriuretic Peptide or N-Terminal proB-Type Natriuretic Peptide for Etiologies Other than Acute Coronary Syndromes and Heart Failure (2007) (1)
Long-Term Outcomes of Hospitalized Patients with a Non-Acute Coronary Syndrome Diagnosis and an Elevated Cardiac Troponin Level (2013) (1)
Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction. (2021) (1)
Clinical chemistry : cardiovascular disorders (1991) (0)
The clinical use and performance of high-sensitivity (hs) cardiac troponin assays with the ESC 0–1 hour algorithm: Overcoming challenges in implementation (2019) (0)
A Single High Sensitivity Cardiac Troponin I Measurement from Siemens Healthineers Can Be Used to Rule out Acute Myocardial Infarction at Low Risk in Patients Presenting to the Emergency Department (2018) (0)
RISK ASSESSMENT OF EMERGENCY DEPARTMENT PATIENTS WITH HIGH SENSITIVITY CARDIAC TROPONIN I CONCENTRATIONS BELOW THE 99TH PERCENTILE SEX-SPECIFIC UPPER REFERENCE LIMITS (2021) (0)
Novel Immunoassay for Quantification of Brain Natriuretic Peptide and the Propeptide in Human Blood (2008) (0)
387 Dispositions for Patients Ruled Out for Acute Myocardial Infarction Using a 1-Hour High Sensitivity Troponin I Algorithm: Home or Hospital? (2020) (0)
Practice Guidelines : Clinical Utilization of Cardiac Biomarker Testing in Heart Failure WRITING GROUP MEMBERS (2007) (0)
P4674Towards the use of objective diagnostic criteria for diagnosing type 2 myocardial infarction (2017) (0)
ERRATUM (2004) (0)
Neopterin: Still a Forgotten Biomarker Dr. Apple responds (2005) (0)
Abstract 16818: Circulating Cardiac Troponin I as Detected By a High-Sensitivity Assay among Patients Hospitalized with Acute Decompensated Heart Failure (2011) (0)
ALTERATIONS OF CARDIAC TROPONIN T IN MYOCARDIUM AND SERUM FOLLOWING ACUTE PROLONGED INTENSE SWIMMING IN TRAINED AND UNTRAINED RATS (1999) (0)
122: THE EFFECT OF MARATHON RUNNING ON GASTRO INTESTINAL TRANSIT TIME AND FECAL BLOOD LOSS IN WOMEN RUNNERS (1987) (0)
18: Rapid Rule Out of Myocardial Infarction With High Sensitivity Newer Generation Cardiac Troponin (2008) (0)
US VALIDATION AND MODIFICATION OF THE HIGH-STEACS PATHWAY USING SERIAL HS-CTNI TO IDENTIFY EMERGENCY DEPARTMENT PATIENTS AT LOW RISK FOR ADVERSE EVENTS (2019) (0)
serum of rats after stressful, prolonged intense exercise Cardiac troponin T alterations in myocardium and (2015) (0)
Corrigendum to “Evaluation of a point-of-care assay for cardiac markers for patients suspected of acute myocardial infarction” [Clin. Chim. Acta 346 (2004) 211–219] (2005) (0)
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Outcomes in ED patients with non‐specific ECG findings and low high‐sensitivity troponin (2022) (0)
175: EARLY DETECTION OF SKELETAL MUSCLE DAMAGE BY ANALYSIS OF SERUM CK MM ISOFORMS (1987) (0)
BIOCHEMICAL MARKERS OF CARDIAC INJURY IN NORMAL AND SURVIVING VERSUS NON-SURVIVING SEPTICEMIC NEONATAL FOALS (2004) (0)
BIOMARKER MODEL FOR CORONARY ARTERY DISEASE (2016) (0)
Use of Cardiac Troponin in Patients in Non‐Ischemic Pathologies and Exposure to Environmental Toxins (2008) (0)
Do High-Sensitivity Cardiac Troponin I Clinical Performance Data in Package Inserts Reflect Realistic Clinical Expectations? (2018) (0)
ORIGINAL ARTICLE Relationship Between Blood Alcohol Concentration and Observable Symptoms of Intoxication in Patients Presenting to an Emergency Department (2013) (0)
176: ENZYMATIC ESTIMATION OF SKELETAL MUSCLE DAMAGE AFTER MARATHON RACING (1987) (0)
Clinical Chemistry Question and Answer (1999) (0)
PROGNOSTIC VALUE OF CARDIAC TROPONIN I DEFINED MYOCARDIAL NECROSIS AND IMPAIRED RENAL FUNCTION IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH ISCHEMIC SYMPTOMS (2014) (0)
Correction: Heroin‐related deaths from the Hennepin County medical examiner's office from 2004 through 2015 (2020) (0)
Creatinine Clearance: Enzymatic vsJaff#{233} Determinations of Creatinine in PlasmaandUrine (1986) (0)
How to use high-sensitivity cardiac troponin assays in everyday clinical practice (2014) (0)
Observational Study of Receptor Binding Domain Spike Antibody Responses to 3 SARS-CoV-2 Vaccinations in Noninfected Subjects: Parallel Neutralizing Antibody and Cardiac Troponin I and T Observations (2022) (0)
Hospitalization of Low Risk Chest Pain Patients With Normal Troponin and Copeptin (2016) (0)
3 Non-specific ECG Findings in Patients with Low High-Sensitivity Troponin Values Are Not Associated With Significant 30-day Adverse Outcomes (2020) (0)
Sex-Speci ﬁ c Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome (2019) (0)
Edinburgh Research Explorer Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome (2019) (0)
Point-of-care I-stat Cardiac Troponin I for Assess- Ment of Patients with Symptoms Suggestive of Acute (0)
Applications et futur de la spectrométrie de masse en médecine de laboratoire (2015) (0)
EFFECTS OF GENDER AND ESTROGEN ADMINISTRATION ON MUSCLE OK ACTIVITY IN RAT SKELETAL MUSCLE: 337 (1992) (0)
for Biomarkers of Heart Failure Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical Issues National Academy of Clinical Biochemistry and IFCC Committee for Standardization of (2013) (0)
Assessment of Renal Functionby InulinClearance : Comparisonwith CreatinineClearance as Determinedby EnzymaticMethods (2004) (0)
A-067 The NT-proBNP level in Subclinical stage of cardiac structural or functional abnormalities among health checkups (2018) (0)
DORA '94-96: Directory of Rare Analyses Jocelyn M. Hicks, Donald S. Young. Washington, DC: AACC Press, 1994, 439 pp., $80.00. ISBN 0-915274-72-8 (1995) (0)
Thanks to Reviewers2017 (2017) (0)
Cardiac troponin measurements for risk stratification in acute coronary syndrome patients using 99th percentile limits for eight assays (2003) (0)
Kinetics of High-Sensitivity Cardiac Troponin Release Following a Strenuous Swimming Test: 1213 Board #21 May 31 8 (2018) (0)
GENDER DIFFERENCES IN MORTALITY AMONG PATIENTS WITH SUPPLY-DEMAND TYPE 2 MYOCARDIAL INFARCTION, TYPE 1 MYOCARDIAL INFARCTION AND NON-MI CARDIAC TROPONIN I INCREASES (2015) (0)
PROLONGED EXERCISE INDUCED THORACIC AORTA ENDOTHELIAL CELL INJURY IN RATS (1998) (0)
A 48‐Year‐Old Cocaine User with Chest Pain (2006) (0)
M.l. Received Funding from the Mayo Endowment. F.a. Has Received Honoraria and Research Funding from Biosite and Beckman Coulter. Pediatric Tube Direct Sampling by the Abbott Architect Integrated Ci8200 Chemistry/immunochemistry Analyzer (2006) (0)
Patients with low high-sensitivity troponin i values have similar outcomes whether discharged or hospitalized (2020) (0)
Heart-type Fatty Acid Binding Protein as a Marker of Ischaemia in Patients Undergoing Percutaneous Coronary Intervention (2015) (0)
Iron status of older marathhon runners and effects of marathon racing on serum ferritin levels (1985) (0)
Update on quality specifications for cardiac troponin assays (2014) (0)
In Reply: Cardiac Troponin-T and Diagnostic Test Evaluation (1995) (0)
proadrenomedullin predicts mortality and major adverse cardiac events in patients presenting with chest pain : Results from the CHOPIN trial Permalink (2015) (0)
What is the IMA assay really saying? (2005) (0)
Abstract 19668: Resource Utilization in the Era of Contemporary Sensitive Cardiac Troponin Assays: Comparisons Among Type 1 Myocardial Infarction, Type 2 Myocardial Infarction, Non-Myocardial Infarction Troponin Increases, and Patients with Negative Troponin (2014) (0)
Predictive Value of NT-proBNP in Patients with Acute Myocardial Infarction (2017) (0)
A 45‐Year‐Old Man with Substantial Chest Pain (2006) (0)
Basics of Cardiac Troponin: Practical Aspects of Assays, Potential Analytical Confounders, and Clinical Interpretation (2008) (0)
CARDIAC TROPONIN-T AND DIAGNOSTIC TEST EVALUATION. AUTHORS' REPLY (1995) (0)
Brain Natriuretic Peptide (2002) (0)
Abstract 3610: Troponin and BNP: Heart Failure's Deadly Duo (2006) (0)
Clinical and Forensic Studies Involving Thiocyanate and Cocaine (1996) (0)
Laboratory and clinical practice guides for improved diagnostics and risk assessment outcomes: Let's talk about high-sensitivity cardiac troponin I (2019) (0)
KINETIC COMPARISON OF HUMAN SKELETAL AND HEART MUSCLE CREATINE KINASE ISOENZYMES (1986) (0)
ALTERATIONS OF CARDIAC SPECIFIC TROPONIN I AND TROPONIN T IN MYOCARDIUM AND SERUM FOLLOWING ACUTE PROLONGED SWIMMING IN RATS (1998) (0)
Serum Enzyme Changes During Marathon Training (1984) (0)
Letter in response to "Use of preoperative cardiac troponin T to identify patients at risk for acute myocardial infraction and long-term mortality after major noncardiac surgery". (2014) (0)
Comprar Management of Food Allergens | Jesse E. Adams | 9781405167581 | Wiley (2009) (0)
Comprar Markers in Cardiology | Jesse Adams | 9781405134187 | Blackwell Publishing (2007) (0)
Abstract 11604: The Relationship of Sudden Death and All-cause Mortality to Baseline Values of High-sensitivity Cardiac Troponin T and I in the EVOLVE Trial (2017) (0)
DIAGNOSTIC PERFORMANCE OF A HIGH-SENSITIVITY CARDIAC TROPONIN I FOR ACUTE MYOCARDIAL INFARCTION USING SEX-SPECIFIC 99TH PERCENTILES DERIVED FROM THE AMERICAN ASSOCIATION OF CLINICAL CHEMISTRY UNIVERSAL SAMPLE BANK (2018) (0)
Fetal Death In Utero (1990) (0)
Clinical Chemistry Question and Answer (1999) (0)
Correction (2020) (0)
iomarkers in Acute Cardiac Disease he Present and the Future (2006) (0)
Challenges Interpreting Cardiac Troponin Values (2009) (0)
EFFECTS OF HINDLIMB SUSPENSION, VITAMIN E SUPPLEMENTATION, AND EXERCISE ON RAT HEART ANTIOXIDANT ENZYMES 373 (1996) (0)
CAN A SECOND MEASUREMENT OF COPEPTIN IMPROVE ACUTE MYOCARDIAL INFARCTION RULE OUT (2014) (0)
Abstract 18942: High Sensitivity Cardiac Troponin I Changes Within The Normal Range Do Not Predict Adverse Events In Patients Presenting With Suspected Myocardial Ischemia (2017) (0)
Abstract 18580: High Sensitivity Cardiac Troponin Sex Specific 99th Percentiles Derived From Universal Sample Bank (2017) (0)
MUSCLE CREATINE KINASE ISOENZYME ALTERATIONS IN WOMEN MARATHON RUNNERS (1985) (0)
44 Rapid Rule-Out of Type 1 Acute Myocardial Infarction Using a Contemporary Cardiac Troponin I Assay with Initial Undetectable Concentrations or Serial Concentrations Below the 99th Percentile (2016) (0)
The origin and future of cardiac troponin testing. (2022) (0)
Does Copeptin Provide Additional Risk Stratification in Chest Pain Patients With a Mild Troponin Elevation (2014) (0)
Troponin Basics for Clinicians (2016) (0)
CREATINE KINASE M AND B SUBUNIT mRNAs AND ISOENZYME ACTIVITY IN EXERCISE TRAINED RAT SKELETAL MUSCLE: 5 (1980) (0)
MID-REGIONAL PROADRENOMEDULLIN PREDICTS LONG-TERM MORTALITY IN PATIENTS WITH CHEST PAIN (2014) (0)
The Need to Develop Clinical Guidance for the Use of High-Sensitivity Cardiac Troponin in Pediatric and Neonatal Patients. (2022) (0)
Ideal one-hour delta high-sensitivity troponin cutoffs for myocardial infarction in patients with renal dysfunction (2019) (0)
Abstract 1792: Multiple Biomarker Utilization for Detection of Myocardial Infarction Based on Presentation Sample in Patients with Symptoms Suggestive of Acute Coronary Syndrome (2007) (0)
Cardiac Biomarkers: Detection of in‐Hospital Myocardial Reinfarction (2008) (0)
24 Influence of Renal Dysfunction on High-Sensitivity Cardiac Troponin I for Diagnostic Accuracy of Myocardial Infarction and Outcomes Assessment (2018) (0)
HIGH SENSITIVITY TROPONIN VALUES RAPIDLY RULE-OUT MYOCARDIAL INFARCTION AND ALLOW FOR ED DISCHARGE IN A HIGHER RISK PATIENT POPULATION COMPARED TO CONTEMPORARY PRACTICE (2020) (0)
Creatine Kinase lsoenzymeMM Variantsin SkeletalMuscleand Plasma from MarathonRunners (1986) (0)
Abstract 18879: Discordance between ICD-9 Coded Myocardial Infarction and Adjudicated Diagnosis According to the Universal Definition of Myocardial Infarction (2016) (0)
Clinical chemistry. (1991) (0)
Disease Markers Cardiac Biomarkers (2015) (0)
Analysesof CreatineKinaselsoenzymes and Isoforms in Serumto DetectReperfusion after AcuteMyocardial Infarction1 (1987) (0)
Beta-hydroxybutyrate assay does not cross-react with gamma-hydroxybutyrate. (2002) (0)
386 Cardiac Testing of Patients Ruled Out for Acute Myocardial Infarction Using a Rapid High Sensitivity Troponin I Algorithm, but Not Discharged (2020) (0)
Advanced CKD, Delta Troponins, Mortality: A Step Toward a Customized Approach During a Perilous Transition? (2022) (0)

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What Schools Are Affiliated With Fred s. Apple?

Fred s. Apple is affiliated with the following schools:

University of Minnesota