Frederick R. Maxfield
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Frederick R. Maxfieldbiology Degrees
Biology
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#7463
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Cell Biology
#136
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#143
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Neuroscience
#561
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#584
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Biochemistry
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#662
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Biology
Frederick R. Maxfield's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Frederick R. Maxfield Influential?
(Suggest an Edit or Addition)Frederick R. Maxfield's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Endocytic recycling (2004) (1505)
- Role of cholesterol and lipid organization in disease (2005) (1159)
- Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor (1996) (678)
- Membrane transport in the endocytic pathway. (1995) (675)
- Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. (1980) (641)
- Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils (1995) (575)
- Rapid acidification of endocytic vesicles containing α 2-macroglobulin (1982) (571)
- Segregation of transferrin to a mildly acidic (pH 6.5) para-golgi compartment in the recycling pathway (1984) (565)
- Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts (1982) (532)
- Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process (1993) (511)
- Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking. (1994) (508)
- Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones (1980) (497)
- Legionella pneumophila inhibits acidification of its phagosome in human monocytes (1984) (387)
- Endocytic Sorting of Lipid Analogues Differing Solely in the Chemistry of Their Hydrophobic Tails (1999) (380)
- Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump (1995) (357)
- Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome (1989) (337)
- Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis (2003) (335)
- Collection of insulin, EGF and α 2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization (1978) (330)
- Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. (1998) (322)
- Cholesterol‐dependent retention of GPI‐anchored proteins in endosomes (1998) (313)
- Cholesterol depletion induces large scale domain segregation in living cell membranes (2001) (308)
- Cholesterol, the central lipid of mammalian cells. (2010) (301)
- Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment. (1995) (298)
- Vesicular and Non-vesicular Sterol Transport in Living Cells (2002) (292)
- Plasma membrane microdomains. (2002) (289)
- Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids (2004) (279)
- Slow Degradation of Aggregates of the Alzheimer’s Disease Amyloid β-Protein by Microglial Cells* (1997) (275)
- Transient increases in cytosolic free calcium appear to be required for the migration of adherent human neutrophils [published erratum appears in J Cell Biol 1990 Mar;110(3):861] (1990) (274)
- Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells (2001) (271)
- Membrane domains. (2004) (257)
- An Endocytosed TGN38 Chimeric Protein Is Delivered to the TGN after Trafficking through the Endocytic Recycling Compartment in CHO Cells (1998) (247)
- Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing (2017) (247)
- Role of Membrane Organization and Membrane Domains in Endocytic Lipid Trafficking (2000) (243)
- Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells (2010) (241)
- Characterization of Rapid Membrane Internalization and Recycling* (2000) (237)
- Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. (2007) (224)
- Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration. (2000) (220)
- Quantification of low density lipoprotein and transferrin endocytic sorting HEp2 cells using confocal microscopy. (1994) (220)
- Intracellular sterol dynamics. (2009) (215)
- Uptake, Degradation, and Release of Fibrillar and Soluble Forms of Alzheimer's Amyloid β-Peptide by Microglial Cells* (1999) (215)
- Niemann‐Pick type C disease: molecular mechanisms and potential therapeutic approaches (2011) (211)
- Sphingomyelinase Treatment Induces ATP-independent Endocytosis (1998) (210)
- Lipid and cholesterol trafficking in NPC. (2004) (208)
- Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin. (1992) (207)
- Amines inhibit the clustering of α2-macroglobulin and EGF on the fibroblast cell surface (1979) (206)
- Chimeric Forms of Furin and Tgn38 Are Transported from the Plasma Membrane to the Trans-Golgi Network via Distinct Endosomal Pathways (1999) (205)
- Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor (1987) (198)
- Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes (1992) (197)
- Intracellular cholesterol transport (2002) (195)
- Acidification of endocytic vesicles by an ATP-dependent proton pump (1983) (188)
- Bafilomycin A1 Treatment Retards Transferrin Receptor Recycling More than Bulk Membrane Recycling* (1997) (187)
- Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages (2017) (187)
- Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts (2011) (186)
- Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (1991) (185)
- alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions (1979) (184)
- The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. (2007) (184)
- Sterols are mainly in the cytoplasmic leaflet of the plasma membrane and the endocytic recycling compartment in CHO cells. (2008) (181)
- Analysis of cholesterol trafficking with fluorescent probes. (2012) (180)
- Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity. (2017) (179)
- Microinjection of Ca++-calmodulin causes a localized depolymerization of microtubules (1983) (176)
- Distribution and transport of cholesterol in Caenorhabditis elegans. (2001) (170)
- Membrane Lipid Organization Is Critical for Human Neutrophil Polarization* (2003) (169)
- Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment (1995) (153)
- Local cytoplasmic calcium gradients in living mitotic cells (1985) (151)
- Rapid acidification of endocytic vesicles containing asialoglycoprotein in cells of a human hepatoma line (1983) (143)
- Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (glu) microtubules and kinesin. (2002) (142)
- Oriented endocytic recycling of α5β1 in motile neutrophils (2000) (140)
- Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control (2008) (139)
- Acidification of endocytic compartments and the intracellular pathways of ligands and receptors (1984) (138)
- Dynamic imaging of neutrophil migration in three dimensions: mechanical interactions between cells and matrix (1997) (134)
- Cytoskeleton-dependent membrane domain segregation during neutrophil polarization. (2001) (133)
- Stearoyl-CoA Desaturase Inhibits ATP-binding Cassette Transporter A1-mediated Cholesterol Efflux and Modulates Membrane Domain Structure* (2003) (130)
- Early Events in Phagosome Establishment Are Required for Intracellular Survival of Legionella pneumophila (1998) (128)
- Attachment to fibronectin or vitronectin makes human neutrophil migration sensitive to alterations in cytosolic free calcium concentration (1991) (126)
- The Distal Pathway of Lipoprotein-induced Cholesterol Esterification, but Not Sphingomyelinase-induced Cholesterol Esterification, Is Energy-dependent* (1996) (126)
- Intracellular sterol transport and distribution. (2006) (122)
- Spreading of human neutrophils is immediately preceded by a large increase in cytoplasmic free calcium. (1986) (119)
- Evidence for nonvectorial, retrograde transferrin trafficking in the early endosomes of HEp2 cells (1995) (118)
- Endocytosed beta-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages (1990) (117)
- Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts. (1980) (115)
- Endocytosed cation-independent mannose 6-phosphate receptor traffics via the endocytic recycling compartment en route to the trans-Golgi network and a subpopulation of late endosomes. (2003) (114)
- Endosome acidification and the pathways of receptor-mediated endocytosis. (1987) (114)
- Human transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domain. (1990) (113)
- Acidification of morphologically distinct endosomes in mutant and wild- type Chinese hamster ovary cells (1987) (111)
- Cytosolic free calcium increases before and oscillates during frustrated phagocytosis in macrophages (1987) (111)
- Fusion accessibility of endocytic compartments along the recycling and lysosomal endocytic pathways in intact cells (1989) (110)
- Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins. (2009) (109)
- STARD4 abundance regulates sterol transport and sensing (2011) (108)
- Applications of ratio fluorescence microscopy in the study of cell physiology (1994) (105)
- Status of empirical methods for the prediction of protein backbone topography. (1976) (104)
- Preparation of solutions with free calcium concentration in the nanomolar range using 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid. (1991) (103)
- Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models (2016) (101)
- Kinetics of endosome acidification in mutant and wild-type Chinese hamster ovary cells (1987) (101)
- Local and global changes in cytosolic free calcium in neutrophils during chemotaxis and phagocytosis. (1990) (99)
- Role of endosomes and lysosomes in human disease. (2014) (99)
- Rapid nonvesicular transport of sterol between the plasma membrane domains of polarized hepatic cells. (2002) (96)
- Effects of Cholesterol Depletion and Increased Lipid Unsaturation on the Properties of Endocytic Membranes*[boxs] (2004) (95)
- Elevated Plasma Membrane Cholesterol Content Alters Macrophage Signaling and Function (2005) (94)
- Direct Observation of Rapid Internalization and Intracellular Transport of Sterol by Macrophage Foam Cells (2005) (93)
- Deletion of ABCA1 and ABCG1 Impairs Macrophage Migration Because of Increased Rac1 Signaling (2011) (93)
- Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol1s⃞ Published, JLR Papers in Press, September 21, 2006. (2006) (92)
- Microtubule asymmetry during neutrophil polarization and migration. (2002) (92)
- Tumor necrosis factor increases the number of epidermal growth factor receptors on human fibroblasts. (1987) (92)
- Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl- phenylalanine (1995) (91)
- Transition from metaphase to anaphase is accompanied by local changes in cytoplasmic free calcium in Pt K2 kidney epithelial cells. (1986) (91)
- SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis Published, JLR Papers in Press, November 2, 2007. (2008) (88)
- A Murine Niemann-Pick C1 I1061T Knock-In Model Recapitulates the Pathological Features of the Most Prevalent Human Disease Allele (2015) (87)
- Intracellular calcium levels correlate with speed and persistent forward motion in migrating neutrophils. (1995) (86)
- Intracellular fusion of sequentially formed endocytic compartments (1988) (86)
- Improvement in Lipid and Protein Trafficking in Niemann‐Pick C1 Cells by Correction of a Secondary Enzyme Defect (2010) (84)
- Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes (2011) (84)
- (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells. (2008) (80)
- Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. (2010) (80)
- Degradation of fibrillar forms of Alzheimer's amyloid β-peptide by macrophages (2008) (79)
- Changes in yolk platelet pH during Xenopus laevis development correlate with yolk utilization. A quantitative confocal microscopy study. (1994) (78)
- Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells Published, JLR Papers in Press, November 15, 2005. (2006) (78)
- The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected (1993) (77)
- Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation[S] (2016) (76)
- Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cellss⃞s⃞ The online version of this article (available at http://www.jlr.org) contains an additional two figures. Published, JLR Papers in Press, December 16, 2003. DOI 10.1194/jlr.M300440-JL (2004) (76)
- Receptor-mediated endocytosis of diphtheria toxin by cells in culture. (1982) (75)
- Regulation of neutrophil motility and adhesion by intracellular calcium transients. (1993) (74)
- The endocytic pathway in microglia during health, aging and Alzheimer’s disease (2016) (74)
- Oriented endocytic recycling of alpha5beta1 in motile neutrophils. (2000) (74)
- Isolation of a temperature‐sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment (1993) (74)
- Thyrotropin-releasing hormone-induced changes in intracellular [Ca2+] measured by microspectrofluorometry on individual quin2-loaded cells (1984) (74)
- Long-lasting and rapid calcium changes during mitosis (1988) (72)
- Unique Cellular Events Occurring during the Initial Interaction of Macrophages with Matrix-retained or Methylated Aggregated Low Density Lipoprotein (LDL) (1999) (71)
- Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits. (1979) (70)
- Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages (1993) (69)
- Effects of Incorporation of Immunoglobulin G and Complement Component C1q on Uptake and Degradation of Alzheimer's Disease Amyloid Fibrils by Microglia* (2000) (69)
- The Uptake and Degradation of Matrix-bound Lipoproteins by Macrophages Require an Intact Actin Cytoskeleton, Rho Family GTPases, and Myosin ATPase Activity* (2001) (68)
- The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages (1991) (67)
- Immunoliposomes with different acid sensitivities as probes for the cellular endocytic pathway. (1989) (66)
- Flotillas of lipid rafts fore and aft (2001) (66)
- Improvements in the prediction of protein backbone topography by reduction of statistical errors. (1979) (65)
- Calcium and signal transduction in granulocytes (1996) (65)
- Sterol, Protein and Lipid Trafficking in Chinese Hamster Ovary Cells with Niemann‐Pick Type C1 Defect (2007) (64)
- Rapid acidification of endocytic vesicles containing alpha 2-macroglobulin. (1982) (61)
- Sterol and lipid trafficking in mammalian cells. (2006) (61)
- Cell surface dynamics of GPI-anchored proteins. (1997) (60)
- Endocytic recycling compartments altered in cisplatin-resistant cancer cells. (2006) (59)
- Regulation of leukocyte locomotion by Ca2+. (1993) (59)
- Effects of Apoprotein E on Intracellular Metabolism of Model Triglyceride-rich Particles Are Distinct from Effects on Cell Particle Uptake (*) (1995) (58)
- The effect of neighboring charges on the helix forming ability of charged amino acids in proteins. (1975) (58)
- A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux (2017) (57)
- Multiphoton microscopy for structure identification in human prostate and periprostatic tissue: implications in prostate cancer surgery (2011) (57)
- Immunolocalization of Acyl-Coenzyme A:CholesterolO-Acyltransferase in Macrophages* (1998) (57)
- Cholesterol trafficking and distribution. (2015) (56)
- Sphingosine kinases are not required for inflammatory responses in macrophages. (2016) (55)
- Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium (2014) (55)
- Regulation of endocytic processes by pH. (1988) (55)
- Elevated Cholesterol Levels in the Plasma Membranes of Macrophages Inhibit Migration by Disrupting RhoA Regulation (2007) (54)
- Multiphoton microscopy in the evaluation of human bladder biopsies. (2012) (54)
- Conformational changes in the receptors for epidermal growth factor and asialoglycoproteins induced by the mildly acidic pH found in endocytic vesicles. (1984) (54)
- Treatment of Niemann–Pick Type C Disease by Histone Deacetylase Inhibitors (2013) (53)
- Intracellular calcium and calcineurin regulate neutrophil motility on vitronectin through a receptor identified by antibodies to integrins alphav and beta3 (1996) (53)
- Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine. (1981) (51)
- Yolk platelets in Xenopus oocytes maintain an acidic internal pH which may be essential for sodium accumulation (1994) (50)
- Cholesterol and matrisome pathways dysregulated in astrocytes and microglia (2022) (50)
- Membrane dynamics and organelle biogenesis—lipid pipelines and vesicular carriers (2017) (50)
- Human bladder cancer diagnosis using multiphoton microscopy (2009) (50)
- Phagocytosis of Wild-Type Legionella pneumophila Occurs through a Wortmannin-Insensitive Pathway (2001) (50)
- Effects of buffering intracellular free calcium on neutrophil migration through three‐dimensional matrices (1997) (49)
- Multiphoton microscopy of prostate and periprostatic neural tissue: a promising imaging technique for improving nerve-sparing prostatectomy. (2009) (49)
- Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule. (2000) (48)
- Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. (2009) (48)
- STARD4 Membrane Interactions and Sterol Binding (2015) (47)
- Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages. (2008) (47)
- Phorbol ester treatment increases the exocytic rate of the transferrin receptor recycling pathway independent of serine-24 phosphorylation (1988) (45)
- Enrichment of acyl coenzyme A:cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment. (2000) (45)
- Infrared spectra of the N‐acetyl‐N′‐methylamides of glycine, L‐alanine, and L‐leucine in dilute solutions of chloroform and carbon tetrachloride (1979) (45)
- Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin. (1981) (45)
- Aggregated LDL in Contact With Macrophages Induces Local Increases in Free Cholesterol Levels That Regulate Local Actin Polymerization (2009) (44)
- Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling. (2001) (42)
- Vesicular and Nonvesicular Transport of Phosphatidylcholine in Polarized HepG2 Cells (2001) (41)
- Intracellular free calcium levels are reduced in mitotic Pt K2 epithelial cells. (1985) (40)
- Transferrin receptor containing the SDYQRL motif of TGN38 causes a reorganization of the recycling compartment but is not targeted to the TGN (1996) (39)
- A Raman spectroscopic investigation of the disulfide conformation in oxytocin and lysine vasopressin. (1977) (39)
- Helix-coil stability constants for the naturally occurring amino acids in water. IX. Glutamic acid parameters from random poly(hydroxybutylglutamine-co-L-glutamic acid). (1975) (39)
- STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC (2012) (39)
- Role of cytoplasmic domain serines in intracellular trafficking of furin. (2004) (38)
- The actin cytoskeleton is important for the stimulation of cholesterol esterification by atherogenic lipoproteins in macrophages. (1994) (37)
- Kinetics of α2‐macroglobulin endocytosis and degradation in mutant and wild‐type Chinese hamster ovary cells (1989) (36)
- Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization. (1979) (36)
- Uptake of fibrillar β-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice (2001) (36)
- Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane (2017) (35)
- Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia (2019) (34)
- Cholesterol: stuck in traffic (1999) (34)
- Oxalic acid alters intracellular calcium in endothelial cells. (2004) (33)
- Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse (2016) (33)
- Resting [Ca2+]i and [Ca2+]i transients are similar in fibroblasts from normal and Alzheimer's donors (1992) (33)
- Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts. (1980) (32)
- Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells[S] (2017) (32)
- TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates. (2019) (32)
- The Cytoplasmic Domain of the Low Density Lipoprotein (LDL) Receptor-related Protein, but Not That of the LDL Receptor, Triggers Phagocytosis* (2003) (31)
- Acidification of Endocytic Vesicles and Lysosomes (1985) (30)
- Measurement of vacuolar pH and cytoplasmic calcium in living cells using fluorescence microscopy. (1989) (29)
- Role of an Acidic Cluster/Dileucine Motif in Cation‐Independent Mannose 6‐Phosphate Receptor Traffic (2007) (28)
- Polarized binding of lipoprotein lipase to endothelial cells. Implications for its physiological actions. (1992) (28)
- Conformation of cyclo(L-alanylglycyl-.epsilon.-aminocaproyl), a cyclized dipeptide model for a .beta. bend. 3. Infrared and Raman spectroscopic studies (1981) (27)
- Quantitative Analysis of Monocyte Subpopulations in Murine Atherosclerotic Plaques by Multiphoton Microscopy (2012) (27)
- ACIDIFICATION OF ENDOCYTIC VESICLES AND THE INTRACELLULAR PATHWAYS OF LIGANDS AND RECEPTORS a (1983) (27)
- Acidification-dependent dissociation of endocytosed insulin precedes that of endocytosed proteins bearing the mannose 6-phosphate recognition marker. (1990) (27)
- Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics. (2009) (27)
- Optimization of 1,2,5‐Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors (2015) (25)
- Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation (2015) (25)
- Effect of primary amines on interferon action. (1982) (24)
- Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’ (2018) (24)
- Ratio imaging instrumentation. (2003) (23)
- Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain (2018) (23)
- Dynamic Actin Reorganization and Vav/Cdc42-Dependent Actin Polymerization Promote Macrophage Aggregated LDL (Low-Density Lipoprotein) Uptake and Catabolism (2019) (23)
- Role of STARD4 and NPC1 in intracellular sterol transport. (2016) (23)
- Deletion of ABCA 1 and ABCG 1 Impairs Macrophage Migration Because of Increased Rac 1 Signaling (2011) (22)
- Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages* (2013) (20)
- Calcium and Calmodulin in the Regulation of the Microtubular Cytoskeleton a (1986) (20)
- Loss of α2‐macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides (1984) (20)
- Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages. (1997) (20)
- A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination. (2020) (19)
- Fc and C3bi receptors and the differentiation antigen BH2-Ag are randomly distributed in the plasma membrane of locomoting neutrophils (1990) (18)
- Intracellular calcium and calcineurin regulate neutrophil motility on vitronectin through a receptor identified by antibodies to integrins alphav and beta3. (1996) (18)
- 2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease. (2019) (17)
- Membrane order in the plasma membrane and endocytic recycling compartment (2017) (17)
- Chapter 11 Ratio Imaging Instrumentation (1998) (16)
- Internalization and Sorting of Macromolecules: Endocytosis (1991) (16)
- Plasmin Promotes Foam Cell Formation by Increasing Macrophage Catabolism of Aggregated Low-Density Lipoprotein (2013) (16)
- Cyclized dipeptide model for a beta-bend. (1979) (15)
- Efficiency of Immunotoxin Cytotoxicity Is Modulated by the Intracellular Itinerary (2012) (15)
- Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells. (1995) (15)
- Cholesterol Pathways Affected by Small Molecules That Decrease Sterol Levels in Niemann-Pick Type C Mutant Cells (2010) (14)
- Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism[S] (2017) (14)
- Receptors and recognition, series A, volume 6 P. Cuatrecasas and M. F. Greeves, eds. London: Chapman and Hall. 199 pp. $27.50 (1979) (14)
- Nerve Growth Factor Potentiates Bradykinin‐Induced Calcium Influx and Release in PC12 Cells (1991) (14)
- Digestive exophagy: Phagocyte digestion of objects too large for phagocytosis (2019) (13)
- Chapter 2 Fluorescent Analogs of Peptides and Hormones (1988) (13)
- Calcium and pH in cytoplasmic organelles (1985) (13)
- Properties of acidified compartments in hippocampal neurons. (1993) (12)
- Simultaneous addition of EGF prolongs the increase in cytosolic free calcium seen in response to bradykinin in NRK‐49F cells (1988) (12)
- Steroidogenic Acute Regulatory Protein-related Lipid Transfer (START) Proteins in Non-vesicular Cholesterol Transport (2014) (12)
- Progranulin in the hematopoietic compartment protects mice from atherosclerosis. (2018) (12)
- The endosomal–lysosomal system (2004) (11)
- Use of fluorescence microscopy in the study of receptor-mediated endocytosis (1990) (11)
- Kinetics of alpha 2-macroglobulin endocytosis and degradation in mutant and wild-type Chinese hamster ovary cells. (1989) (11)
- mechanical interactions between cells and matrix (1997) (10)
- Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis. (2020) (10)
- A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol[S] (2015) (9)
- Study of the state of ionization of [Leu5]-enkephalin in the crystal and in solution. (2009) (9)
- Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing (2018) (8)
- Fluorescence imaging in living animals. Focus on "Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy". (2004) (8)
- Histone deacetylase inhibitors correct the cholesterol storage defect in most NPC1 mutant cells (2016) (7)
- Quantitative fluorescence techniques for the characterization of endocytosis in intact cells. (1993) (7)
- Lysosomes: Biology, Diseases, and Therapeutics: Biology, Diseases, and Therapeutics (2016) (7)
- Transition from metaphase to anaphase is accompanied by local changes in-cytoplasmic free calcium in Pt K 2 kidney epithelial cells ( fura-2 / digital image processing / mitosis / microtubules / ATP permeabilization ) (6)
- Cell-Cell Signaling in Vertebrate Development (1993) (6)
- High-density lipoprotein or cyclodextrin extraction of cholesterol from aggregated LDL reduces foam cell formation (2019) (6)
- Spectroscopic study of the conformations of proline-containing oligopeptides in the crystalline state and in solution. (2009) (6)
- Analyzing Microdomains in Biological Membranes Using Fluorescence Techniques (2001) (6)
- Lysosomes : biology, diseases, and therapeutics (2016) (5)
- Oriented endocytic recycling of a 5 b 1 in motile neutrophils (2000) (5)
- Fluorescent analogs of peptides and hormones. (1989) (5)
- CONFORMATIONALSTUDY OF [LEU5]‐ENKEPHALIN BY LASER RAMAN SPECTROSCOPY (2009) (4)
- Intramembrane and Intermembrane Lipid Transport (2016) (4)
- Model of the Structure of the StART domains of human MLN64 in Complex with Cholesterol (2006) (4)
- HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts (2021) (4)
- Parallel analysis of v-Src mutant protein function using reverse transfection cell arrays. (2006) (4)
- Targeted Drug Delivery (1991) (3)
- Erratum: Sphingosine kinases are not required for inflammatory responses in macrophages (The Journal of Biological Chemistry 288 (2013) 2563-32573) (2016) (3)
- WITHDRAWN: Parallel analysis of v-SRC mutant protein function using reverse transfection cell arrays. (2006) (3)
- Phosphatidylinositol phosphates modulate interactions between the StarD4 sterol trafficking protein and lipid membranes (2022) (3)
- Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils (2019) (3)
- Acidification of Endosomes and Phagosomes (2009) (3)
- Role of Lysosomes in Lipid Metabolism (2016) (2)
- Conformational study of [Leu5]-enkephalin by laser Raman spectroscopy. (1980) (2)
- Lysosomes: An Introduction (2016) (2)
- Optical Microscopy–Based Migration Assay for Human Neutrophils (2003) (2)
- Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts (2021) (2)
- Targeting molecular chaperone HSP90 to treat Niemann‐Pick type C1 disease (2018) (2)
- TLR4 Signaling Regulates Lysosome Exocytosis to a Novel Extracellular Compartment (2013) (1)
- Introduction: Optical microscopy in physiological investigations (1994) (1)
- Direct Comparision of the Endocytic Routes of Fluorescently-Labelled Lipids and Transferrin (1993) (1)
- IMAGING OF PERIPROSTATIC NEURAL TISSUE WITH MULTIPHOTON MICROSCOPY (2008) (1)
- Comprar Lysosomes. Biology, Diseases, And Therapeutics | Frederick R. Maxfield | 9781118645154 | Wiley (2016) (1)
- Elevated levels of tripeptidyl peptidase 1 do not ameliorate pathogenesis in a mouse model of Alzheimer disease (2022) (1)
- Histone deacetylase inhibitors correct the cholesterol storage defect in most NPC 1 mutant cells (2016) (1)
- Therapeutic potential of histone deacetylase inhibitor for treatment of Niemann-Pick type C1 disease (2014) (1)
- Treatment of Niemann–Pick Type C Disease by Histone Deacetylase Inhibitors (2013) (1)
- Abstract 4884: Toward an annotated digital multiphoton microscopy (MPM) histology atlas of fresh human and rodent tissue for guidance during cancer diagnosis and margin assessments (2011) (0)
- 1345 AUTOFLUORESCENCE MICROSCOPY OF PERIPROSTATIC LYMPHATIC TISSUE AND CORRELATION WITH CONVENTIONAL HISTOPATHOLOGY IMAGING (2010) (0)
- Macrophage catabolism of aggregated lipoproteins using a novel extracellular compartment regulates lipid accumulation during atherosclerosis (2017) (0)
- Abstract MP49: Macrophage-mediated Extracellular Digestive Exophagy Of Aggregated LDL Is Responsible For The Formation Of Cholesterol Crystals In Atherosclerotic Plaques (2021) (0)
- MP-4.16: Real-Time Tissue Imaging of Prostate and Periprostatic Neural Tissue with Multiphoton Microscopy (2008) (0)
- The interplay between lipid and protein trafficking (2009) (0)
- 157Optical non-invasive detection of Niemann-Pick disease in vitro and in vivo (2017) (0)
- Faculty Opinions recommendation of A sterol-binding protein integrates endosomal lipid metabolism with TOR signaling and nitrogen sensing. (2012) (0)
- Ratio imaging instrumentation. (1998) (0)
- Vectorial Cholesterol Transport by STARD4 is Mediated by Specific PIP2 Membrane Composition (2017) (0)
- Membrane Traffic Molecular Structure, Function, and Dynamics of Clathrin-Mediated (2014) (0)
- REAL TIME TISSUE RECOGNITION TECHNIQUE USING MULTIPHOTON MICROSCOPY AND ITS RELEVANCE TO ROBOTIC PROSTATECTOMY (2008) (0)
- Targeting Molecular Chaperone HSP90 To Treat Niemann‐Pick Type C1 Disease (2019) (0)
- Characterization of Endocytic Pathways by Quantitative Fluorescence Microscopy (1998) (0)
- Editorial Board (2010) (0)
- The formation and consequences of cholesterol-rich deposits in atherosclerotic lesions (2023) (0)
- TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates (2019) (0)
- Membrane dynamics and organelle biogenesis—lipid pipelines and vesicular carriers (2017) (0)
- Abstract 497: Cholesterol and Toll-like Receptor Signaling Are Important Regulators of Macrophage Interactions with Atherosclerotic Lipoprotein Aggregates (2012) (0)
- Critical examination of the Uniform Charge Cloud Method (1971) (0)
- Cytosolic free calcium in human neutrophils undergoing chemotaxis (1988) (0)
- Therapeutic potential of histone deacetylase inhibitor for treatment of Niemann-Pick type C1 disease (2014) (0)
- The Influence of Particle Size and Multiple Apoprotein E-Receptor Interactions on the Endocytic Targeting of O3VLDL in Mouse Peritoneal Macrophages (2002) (0)
- Crystal Structure of L124D STARD4 (2015) (0)
- Thyrotropin-releasing Hormone-induced Changes in Intracellular [Ca 2+] Measured by Microspectrofluorometry on Individual quin2-10aded Cells (2002) (0)
- Optical Microscopy Studies of [Ca2+]i Signaling (2019) (0)
- Dynamic Actin Reorganization and Vav/Cdc42‐dependent Actin Polymerization Promote Macrophage Aggregated LDL Uptake and Catabolism (2018) (0)
- REAL-TIME TISSUE RECOGNITION OF PERIPROSTATIC TISSUE ARCHITECTURE AND ITS RELEVANCE T O NERVE SPARING RADICAL PROSTATECTOMY: A PILOT STUDY USING MULTIPHOTON MICROSCOPY AND SECOND HARMONIC GENERATION (2009) (0)
- Macrophages Create a Lysosomal Synapse to Digest Aggregated Lipoproteins (2010) (0)
- 2143 REAL TIME DELINEATION PROSTATIC ARCHITECTURE USING ROBO-MICROSCOPY PROJECT TWO PHOTON LASER EXCITATION IMAGING IN VISUALIZATION OF HUMAN PROSTATIC TISSUE (2010) (0)
- TLR4 signaling regulates PI3 kinase activation and macrophage exophagy (796.16) (2014) (0)
- Cells Associated with Altered Lipid Order in HT 29 Colon Cancer Activation of the Epidermal Growth Factor Receptor Is )-Epigallocatechin Gallate on − The Inhibitory Effect of ( Updated (2007) (0)
- Motion in Migrating Neutrophils (2005) (0)
- Bicarbonate/pHi sensitive soluble Adenylyl Cyclase (sAC) regulates lysosomal pH (2014) (0)
- Microsoft Word-macrophageSphkKOfinalRev2.docx (2013) (0)
- 8 Host Cell Membrane Structure and Dynamics (2004) (0)
- Draft 1 Role of STARD 4 and NPC 1 in intracellular sterol transport (2016) (0)
- Human glia‐specific functional dysregulations affected by APOE ε4 risk of Alzheimer's disease (2020) (0)
- Epidermal growth factor stimulation of DNA synthesis (0)
- Abstract 122: Ceramide Activation of Macrophage RhoA/Rho Kinase/LIM Kinase Signaling Impairs Aggregated LDL Degradation and Foam Cell Formation (2015) (0)
- Characterization of endocytosis in intact cells by quantitative fluorescence microscopy (1991) (0)
- Author response: Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’ (2018) (0)
- Phosphatidylinositol Phosphates Modulate STARD4 Sterol Transfer between Membranes (2015) (0)
- Flotillas of lipid rafts fore an (2016) (0)
- Screening of small molecule chemical library identifies leads that reduce cholesterol accumulation in human NPC1 fibroblasts (2022) (0)
- Decision letter: Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid (2019) (0)
- 1444 PERI PROSTATIC NERVE MAPPING: UTILITY OF REAL TIME 780-NM LASER EXCITATION IMAGING IN VISUALIZATION OF HUMAN CAVERNOUS NERVES (2010) (0)
- Structure‐function studies of the sterol transfer protein, STARD4 (606.2) (2014) (0)
- Thyrotropin-releasing Hormone-induced Changes in Intracellular [ Ca 2 + ] Measured by Microspectrofluorometry on Individual quin 2-10 aded Cells (2002) (0)
- Model of the Structure of the StART domains of human Steroidogenic acute regulatory protein (StAR) in Complex with Cholesterol (2006) (0)
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What Schools Are Affiliated With Frederick R. Maxfield?
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