Friedrich Grimminger
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(Suggest an Edit or Addition)Friedrich Grimminger's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Sildenafil citrate therapy for pulmonary arterial hypertension. (2005) (1939)
- Riociguat for the treatment of chronic thromboembolic pulmonary hypertension. (2013) (1074)
- Riociguat for the treatment of pulmonary arterial hypertension. (2013) (1068)
- Reversal of experimental pulmonary hypertension by PDGF inhibition. (2005) (1053)
- Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial (2002) (765)
- Inflammation, growth factors, and pulmonary vascular remodeling. (2009) (663)
- Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy. (2000) (627)
- Real-time quantitative RT–PCR after laser-assisted cell picking (1998) (613)
- Mechanisms of disease: pulmonary arterial hypertension (2011) (608)
- Combination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension (2002) (516)
- Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond (2006) (502)
- Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension: Results of the Randomized IMPRES Study (2013) (481)
- Imatinib for the treatment of pulmonary arterial hypertension. (2005) (469)
- Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema. (1996) (405)
- Aerosolized Prostacyclin and Iloprost in Severe Pulmonary Hypertension (1996) (397)
- Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis. (1999) (386)
- Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension. (2003) (368)
- Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy. (2010) (358)
- Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study. (1996) (355)
- Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome. (2000) (338)
- Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study. (2004) (332)
- Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature (2007) (330)
- Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. (1996) (323)
- Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange (2006) (306)
- Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy (2000) (305)
- Sildenafil Increased Exercise Capacity during Hypoxia at Low Altitudes and at Mount Everest Base Camp (2004) (300)
- Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension. (2003) (289)
- Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice (2011) (289)
- Aerosolised prostacyclin in adult respiratory distress syndrome (1993) (283)
- Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension. (2012) (279)
- Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats. (2004) (272)
- Reproduction of transfusion-related acute lung injury in an ex vivo lung model. (1990) (259)
- First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension (2009) (254)
- Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. (2003) (245)
- Riociguat for the treatment of chronic thromboembolic pulmonary hypertension: a long-term extension study (CHEST-2) (2014) (242)
- Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study (2010) (234)
- Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema. (1996) (228)
- Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension (2008) (228)
- Activation of Soluble Guanylate Cyclase Reverses Experimental Pulmonary Hypertension and Vascular Remodeling (2006) (219)
- Surfactant alteration and replacement in acute respiratory distress syndrome (2001) (218)
- Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia. (2002) (216)
- Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension (2014) (215)
- Short-Time Infusion of Fish Oil-Based Lipid Emulsions, Approved for Parenteral Nutrition, Reduces Monocyte Proinflammatory Cytokine Generation and Adhesive Interaction with Endothelium in Humans 1 (2003) (208)
- Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms (2008) (201)
- Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species. (2004) (192)
- ω-3 vs. ω-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation (2003) (188)
- Sildenafil treatment for portopulmonary hypertension (2006) (187)
- Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension (2005) (186)
- The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups. (2017) (183)
- A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension (2009) (180)
- Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension (2007) (175)
- Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis. (1996) (175)
- Phenotypic characterization of alveolar monocyte recruitment in acute respiratory distress syndrome. (2000) (174)
- Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients (2006) (171)
- Simvastatin Inhibits Inflammatory Properties of Staphylococcus aureus &agr;-Toxin (2002) (170)
- Riociguat for the treatment of pulmonary arterial hypertension: a long-term extension study (PATENT-2) (2015) (169)
- Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice (2012) (168)
- Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits. (2003) (167)
- Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension. (2012) (165)
- Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension. (2004) (162)
- Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer. (2015) (162)
- Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14. (2001) (158)
- Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies. (2006) (147)
- Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features. (2003) (146)
- Combined Tyrosine and Serine/Threonine Kinase Inhibition by Sorafenib Prevents Progression of Experimental Pulmonary Hypertension and Myocardial Remodeling (2008) (143)
- Phosphodiesterase 1 Upregulation in Pulmonary Arterial Hypertension: Target for Reverse-Remodeling Therapy (2007) (141)
- Monocyte Migration Through the Alveolar Epithelial Barrier: Adhesion Molecule Mechanisms and Impact of Chemokines1 (2000) (140)
- The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies. (2000) (136)
- Abnormalities of gastric mucosal oxygenation in septic shock: partial responsiveness to dopexamine. (1998) (134)
- Targeting cancer with phosphodiesterase inhibitors (2010) (134)
- Phosphodiesterase inhibitors for the treatment of pulmonary hypertension (2008) (134)
- Targeting non-malignant disorders with tyrosine kinase inhibitors (2010) (133)
- Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia. (2001) (132)
- Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA. (2007) (131)
- New trial designs and potential therapies for pulmonary artery hypertension. (2013) (129)
- Endotoxin-Induced Myocardial Tumor Necrosis Factor-&agr; Synthesis Depresses Contractility of Isolated Rat Hearts: Evidence for a Role of Sphingosine and Cyclooxygenase-2–Derived Thromboxane Production (2000) (128)
- Role of epidermal growth factor inhibition in experimental pulmonary hypertension. (2010) (126)
- Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. (2002) (126)
- Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis. (1999) (126)
- ω-3 Fatty acid–based lipid infusion in patients with chronic plaque psoriasis: Results of a double-blind, randomized, placebo-controlled, multicenter trial (1998) (125)
- NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts. (2008) (124)
- Predictors of long-term outcomes in patients treated with riociguat for chronic thromboembolic pulmonary hypertension: data from the CHEST-2 open-label, randomised, long-term extension trial. (2016) (123)
- The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis (2015) (123)
- Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis. (1995) (119)
- Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension. (2001) (117)
- Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF (2013) (116)
- Role of Src Tyrosine Kinases in Experimental Pulmonary Hypertension (2012) (116)
- Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary Vasoconstriction and Pulmonary Vascular Remodeling (2006) (113)
- n-3 Fatty acids in psoriasis (2002) (112)
- Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair. (2009) (111)
- Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells‐role of hypoxia‐inducible transcription factors (2002) (110)
- Pulmonary Vascular Disease in the Developing World (2008) (109)
- Nitric oxide generation and hypoxic vasoconstriction in buffer-perfused rabbit lungs. (1995) (108)
- Antiremodeling Effects of Iloprost and the Dual-Selective Phosphodiesterase 3/4 Inhibitor Tolafentrine in Chronic Experimental Pulmonary Hypertension (2004) (107)
- Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells. (2005) (104)
- Riociguat for the treatment of pulmonary arterial hypertension associated with connective tissue disease: results from PATENT-1 and PATENT-2 (2016) (102)
- Evaluation of angiogenesis using micro-computed tomography in a xenograft mouse model of lung cancer. (2009) (100)
- In vivo TRPC functions in the cardiopulmonary vasculature. (2007) (100)
- Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)? (2000) (96)
- Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. (2009) (96)
- Hypoxia‐driven proliferation of human pulmonary artery fibroblasts: cross‐talk between HIF‐1α and an autocrine angiotensin system (2005) (96)
- Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction. (2006) (95)
- The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension. (2009) (94)
- Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells (1993) (92)
- Surfactant protein A down-regulates proinflammatory cytokine production evoked by Candida albicans in human alveolar macrophages and monocytes. (1999) (91)
- Cyclooxygenase isoenzyme localization and mRNA expression in rat lungs. (1998) (91)
- Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma (2015) (91)
- Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats (2010) (91)
- Role of Hypoxia-Inducible Factor-1α in Hypoxia-Induced Apoptosis of Primary Alveolar Epithelial Type II Cells (2005) (90)
- The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats (2012) (90)
- Inflammation, immunological reaction and role of infection in pulmonary hypertension. (2011) (88)
- Smad-Dependent and Smad-Independent Induction of Id1 by Prostacyclin Analogues Inhibits Proliferation of Pulmonary Artery Smooth Muscle Cells In Vitro and In Vivo (2010) (87)
- Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. (2006) (87)
- Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin. (1997) (87)
- Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension. (1997) (86)
- Adult respiratory distress syndrome: model systems using isolated perfused rabbit lungs. (1994) (86)
- cDNA array hybridization after laser-assisted microdissection from nonneoplastic tissue. (2002) (86)
- Predictors of long-term outcomes in patients treated with riociguat for pulmonary arterial hypertension: data from the PATENT-2 open-label, randomised, long-term extension trial. (2016) (84)
- Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension. (2013) (83)
- Fhl-1, a New Key Protein in Pulmonary Hypertension (2008) (82)
- Enhanced Tissue Factor Pathway Activity and Fibrin Turnover in the Alveolar Compartment of Patients with Interstitial Lung Disease (2000) (82)
- Novel and emerging therapies for pulmonary hypertension. (2014) (81)
- Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs. (1995) (81)
- Future perspectives for the treatment of pulmonary arterial hypertension. (2009) (81)
- RNA interference for HIF-1alpha inhibits its downstream signalling and affects cellular proliferation. (2003) (81)
- Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema. (2014) (81)
- Nocturnal periodic breathing in primary pulmonary hypertension (2002) (80)
- Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension. (2005) (80)
- Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing (2017) (79)
- Hypoxic vasoconstriction in buffer-perfused rabbit lungs. (1995) (78)
- Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study (2007) (78)
- Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome? (2005) (78)
- Impact of arachidonic versus eicosapentaenoic acid on exotonin-induced lung vascular leakage: relation to 4-series versus 5-series leukotriene generation. (1997) (78)
- Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. (1996) (78)
- Functional role and species-specific contribution of arginases in pulmonary fibrosis. (2008) (77)
- Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on gas exchange and haemodynamics (2002) (76)
- Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation (1996) (76)
- A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis. (2002) (76)
- Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension. (2008) (76)
- Low-dose systemic phosphodiesterase inhibitors amplify the pulmonary vasodilatory response to inhaled prostacyclin in experimental pulmonary hypertension. (1999) (76)
- Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils. (1991) (75)
- Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats (2011) (75)
- The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism. (1996) (75)
- Alveolar surfactant and adult respiratory distress syndrome (1993) (74)
- Endothelial responses to bacterial toxins in sepsis. (2003) (74)
- Oxygen sensors in hypoxic pulmonary vasoconstriction. (2006) (73)
- Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension (2016) (73)
- Wegener's Granulomatosis: Anti–proteinase 3 Antibodies Are Potent Inductors of Human Endothelial Cell Signaling and Leakage Response (1998) (73)
- NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs. (2001) (72)
- Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties (2002) (71)
- Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. (2000) (71)
- Inhaled iloprost is a potent acute pulmonary vasodilator in HIV‐related severe pulmonary hypertension (2004) (71)
- Cellular pathophysiology and therapy of pulmonary hypertension. (2001) (70)
- Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro. (1991) (70)
- Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling (2007) (70)
- Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species. (2012) (69)
- Basic features of hypoxic pulmonary vasoconstriction in mice (2004) (69)
- Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention (2010) (69)
- Riociguat for the treatment of pulmonary hypertension (2010) (68)
- Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension. (2008) (68)
- Role of Listeria monocytogenes Exotoxins Listeriolysin and Phosphatidylinositol-Specific Phospholipase C in Activation of Human Neutrophils (1999) (68)
- Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells (1996) (67)
- Alveolar antioxidant status in patients with acute respiratory distress syndrome (2004) (67)
- ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension (2017) (67)
- Human Endothelial Cell Activation and Mediator Release in Response to Listeria monocytogenesVirulence Factors (2001) (66)
- Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase. (2005) (66)
- Microenvironmental Th9- and Th17- lymphocytes induce metastatic spreading in lung cancer. (2020) (65)
- Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity. (2001) (65)
- Mediator generation and signaling events in alveolar epithelial cells attacked by S. aureus alpha-toxin. (2002) (64)
- The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis (2011) (64)
- p38 MAPK Inhibition Improves Heart Function in Pressure‐Loaded Right Ventricular Hypertrophy (2017) (64)
- Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non–Small Cell Lung Carcinoma (2020) (64)
- FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis (2017) (64)
- Hydrogen peroxide-induced increase in lung endothelial and epithelial permeability--effect of adenylate cyclase stimulation and phosphodiesterase inhibition. (1995) (63)
- Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy (2009) (63)
- An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid. (1995) (63)
- Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling. (2013) (63)
- Microcirculatory Dysfunction in the Brain Precedes Changes in Evoked Potentials in Endotoxin-Induced Sepsis Syndrome in Rats (2006) (63)
- Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model. (2013) (63)
- Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction. (1999) (63)
- In situ localization of TNFα/β, TACE AND TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue (2003) (61)
- Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation. (2001) (61)
- Lung cancer–associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell–immune cell cross-talk (2017) (61)
- Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange. (2000) (60)
- APOPTOSIS CONTRIBUTES TO SEPTIC CARDIOMYOPATHY AND IS IMPROVED BY SIMVASTATIN THERAPY (2008) (60)
- Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer (2020) (59)
- Amplified canonical transforming growth factor-β signalling via heat shock protein 90 in pulmonary fibrosis (2017) (59)
- Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension (2002) (59)
- Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs. (2003) (59)
- Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: Autocrine role of tumor necrosis factor-&agr; in mediating LTA-induced interleukin-8 generation (2006) (58)
- Physiologic basis for the treatment of pulmonary hypertension. (2001) (57)
- Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial. (1998) (57)
- Severe organising pneumonia following COVID-19 (2020) (57)
- Updated classification and management of pulmonary hypertension (2010) (56)
- Macrophage and Tumor Cell Cross-Talk Is Fundamental for Lung Tumor Progression: We Need to Talk (2020) (56)
- Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6 (2011) (56)
- Arachidonic acid lipoxygenase pathways and increased vascular permeability in isolated rabbit lungs. (1987) (55)
- Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction. (2009) (55)
- The effect of 1 ppm nitrogen dioxide on bronchoalveolar lavage cells and inflammatory mediators in normal and asthmatic subjects. (1995) (55)
- PDGF receptor and its antagonists: role in treatment of PAH. (2010) (54)
- Ultrasonic nebulization for efficient delivery of surfactant in a model of acute lung injury. Impact on gas exchange. (1997) (54)
- Impact of HIF‐1α and HIF‐2α on proliferation and migration of human pulmonary artery fibroblasts in hypoxia (2006) (54)
- Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension (2019) (54)
- Sildenafil Improves Dynamic Vascular Function in the Brain: Studies in Patients with Pulmonary Hypertension (2006) (54)
- Synthesis of arachidonic acid-derived lipoxygenase and cytochrome P450 products in the intact human lung vasculature. (2000) (53)
- Wegener’s granulomatosis: antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release—role of autocrine cell activation (2002) (52)
- Influence of microvascular adherence on neutrophil leukotriene generation. Evidence for cooperative eicosanoid synthesis. (1990) (52)
- On-line measurement of nitric oxide generation in buffer-perfused rabbit lungs. (1995) (52)
- Hypoxic pulmonary vasoconstriction: a multifactorial response? (2001) (51)
- Potentiation of leukotriene production following sequestration of neutrophils in isolated lungs: indirect evidence for intercellular leukotriene A4 transfer. (1988) (51)
- Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis (2014) (51)
- Parenteral nutrition with n-3 lipids in sepsis (2002) (51)
- Influence of intravenous n‐3 lipid supplementation on fatty acid profiles and lipid mediator generation in a patient with severe ulcerative colitis (1993) (50)
- Hypoxia- and non-hypoxia-related pulmonary hypertension - established and new therapies. (2006) (50)
- Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease. (2002) (50)
- Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension (2012) (49)
- Subhemolytic doses of Escherichia coli hemolysin evoke large quantities of lipoxygenase products in human neutrophils. (1991) (49)
- Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension (2010) (48)
- High yield enzymatic conversion of intravascular leukotriene A4 in blood-free perfused lungs. (1988) (48)
- Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury (2008) (48)
- Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation (2012) (48)
- Burden of pulmonary arterial hypertension in Germany. (2010) (48)
- Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia (2009) (48)
- A double-blind, randomized, placebo-controlled trial of n-3 fatty acid based lipid infusion in acute, extended guttate psoriasis (1993) (47)
- Increased neutrophil mediator release in patients with pulmonary hypertension – suppression by inhaled iloprost (2003) (47)
- A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension (2019) (47)
- Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β (2011) (47)
- Evaluation and Prognostic Relevance of Right Ventricular-Arterial Coupling in Pulmonary Hypertension. (2019) (47)
- In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFα impact of ω-3 versus ω-6 fatty acids (2002) (46)
- PROTECTION AGAINST GAS EXCHANGE ABNORMALITIES BY PRE-AEROSOLIZED PGE 1, ILOPROST AND NITROPRUSSIDE IN LUNG ISCHEMIA-REPERFUSION1 (2001) (46)
- Role of actin depolymerization in the surfactant secretory response of alveolar epithelial type II cells. (1999) (46)
- Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge: differential regulation in the various types of cells in the lung. (2000) (45)
- Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2 (2014) (45)
- The science of endothelin‐1 and endothelin receptor antagonists in the management of pulmonary arterial hypertension: current understanding and future studies (2009) (45)
- Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension. (2001) (45)
- Omega-3 lipid infusion in a heart allotransplant model. Shift in fatty acid and lipid mediator profiles and prolongation of transplant survival. (1996) (44)
- Pathophysiology of acute lung injury. (2001) (44)
- Vasoregulatory prostanoid generation proceeds via cyclooxygenase-2 in noninflamed rat lungs. (1998) (43)
- Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension (2018) (42)
- Prostacyclin enhances stretch-induced surfactant secretion in alveolar epithelial type II cells. (1999) (42)
- Efficiency of aerosolized nitric oxide donor drugs to achieve sustained pulmonary vasodilation. (1997) (42)
- Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling (2010) (41)
- Short-term "preconditioning" with inhaled nitric oxide protects rabbit lungs against ischemia-reperfusion injury. (2001) (41)
- Nitro blue tetrazolium inhibits but does not mimic hypoxic vasoconstriction in isolated rabbit lungs. (1998) (41)
- The lectin-like domain of tumor necrosis factor-&agr; improves alveolar fluid balance in injured isolated rabbit lungs* (2008) (41)
- Acceleration of experimental diabetic retinopathy in the rat by omega-3 fatty acids (1996) (41)
- Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up‐regulation of NO‐cGMP signaling (2008) (41)
- Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia. (2009) (40)
- Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension. (2009) (40)
- Glycogen Synthase Kinase 3beta Contributes to Proliferation of Arterial Smooth Muscle Cells in Pulmonary Hypertension (2011) (40)
- Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs (2007) (40)
- Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide. (2003) (39)
- Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis (2015) (39)
- Effects of Multikinase inhibitors on pressure overload-induced right ventricular remodelling (2013) (39)
- The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice. (2009) (39)
- Role of hypoxia-inducible factor-1alpha in hypoxia-induced apoptosis of primary alveolar epithelial type II cells. (2005) (38)
- Type II alveolar epithelial eicosanoid metabolism: predominance of cyclooxygenase pathways and transcellular lipoxygenase metabolism in co-culture with neutrophils. (1992) (38)
- Advantage of buffered solutions or automated capnometry in air-filled balloons for use in gastric tonometry (1997) (38)
- Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia. (2006) (38)
- Ventilation-perfusion mismatch after lung ischemia-reperfusion. Protective effect of nitric oxide. (1999) (38)
- Cell Density Regulates Neutrophil IL-8 Synthesis: Role of IL-1 Receptor Antagonist and Soluble TNF Receptors (2001) (38)
- Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors (2005) (37)
- DNA transfer into human lung cells is improved with Tat-RGD peptide by caveoli-mediated endocytosis. (2006) (37)
- Role of endothelial cytoskeleton in high-permeability edema due to botulinum C2 toxin in perfused rabbit lungs. (1995) (37)
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- Inhibition Of Ca2+/calmodulin-Dependent Phosphodiesterase1A Attenuates Right Ventricular Remodeling And Dysfunction In Two Rat Models (2011) (0)
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- Issue Information (2018) (0)
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- Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension (2001) (0)
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- S8.23 Oxygen dependency of mitochondrial respiratory chain function in hypoxic pulmonary vasoconstriction (2008) (0)
- Correction to: Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice (2022) (0)
- Abstract 1484: Functional and molecular characterization of macrophage-tumor cell communication (2012) (0)
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- Wnt-Signaling Pathway In Experimental Right Heart Hypertrophy (2011) (0)
- Vascular Reverse Remodeling In Hypoxia-induced Pulmonary Arterial Hypertension (2010) (0)
- Reply to Zheng et al. (2021) (0)
- endothelial cells: role of endothelial PAF generation -3 Fatty acids suppress monocyte adhesion to human ω (2016) (0)
- Effect of pH and CO2 on hypoxic pulmonary vasoconstriction and capillary permeability – impact of NO (2008) (0)
- MicroRNA-9 is a regulator of PDGFRβ expression in pulmonary arterial hypertension (2015) (0)
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- Prevention Of Experimental Hypoxia-Induced Pulmonary Hypertension By Moderate Exercise Training In Mice (2011) (0)
- Evaluation of angiopoietin-2 and thrombomodulin as biomarkers for pulmonary hypertension (2013) (0)
- Correction to: Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis (2022) (0)
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- A mouse model of sleep apnea - Role of endothelial and inducible NO synthases (2017) (0)
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- Abstract 1839: Phosphodiesterase 4 regulates lung tumor growth through HIF regulation, proliferation, and angiogenesis (2012) (0)
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- Correction: Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation. (2022) (0)
- Mitochondrial Alterations Of Pulmonary Arterial Smooth Muscle Cells In Pulmonary Hypertension (2011) (0)
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- The Dual Neutral Endopeptidase/Endothelin Converting Enzyme Inhibitor SLV338 Inhibits Experimental Pulmonary Hypertension In Rats (2011) (0)
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- MAP Kinase Mediated Cross-Talk Between Macrophages and Pulmonary Artery Smooth Muscle Cells Is Essential for Tobacco Smoke-Induced Pulmonary Vascular Remodeling (2022) (0)
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- Vascular reverse remodeling in the mouse model of hypoxia-induced pulmonary hypertension – role of AMD-1 (2011) (0)
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- Inhibition of Janus Kinase 2 -Signal Transducer and Activator of Transcription 3 (JAK2-STAT3) Pathway as a Therapeutic Option for Pulmonary Hypertension (2019) (0)
- Abstract 17755: Effects of Multikinase Inhibitors on Right Ventricular Remodeling (2010) (0)
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- Additional file 1: Figure S1. of Survival with sildenafil and inhaled iloprost in a cohort with pulmonary hypertension: an observational study (2016) (0)
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- Correction: Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice (2011) (0)
- 6 Phosphodiesterase-5 inhibitors in pulmonary arterial hypertension (2008) (0)
- Alveolar Remodeling in a Mouse Model of Chronic Tobacco Smoke Inhalation (2008) (0)
- Role Of Notch Signaling In Pulmonary Arterial Hypertension (2011) (0)
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- Vasoconstriction and Pulmonary Vascular Remodeling Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary (2006) (0)
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- Emerging Role of Adenylate Kinase 4 as a Metabolic Player Regulating Cellular Hypoxic Responses in Pulmonary Cells (2019) (0)
- Echocardiographic assessment of right ventricular structure and function in hypoxic induced pulmonary hypertension – effects of Riociguat and Sildenafil (2012) (0)
- Omega-3 Fatty Acid Expression Attenuates Chronic Hypoxia-Induced and Smoke-Induced Pulmonary Hypertension (2022) (0)
- The physiological function of the purinergic receptor P2Y2 in pulmonary arterial endothelial cells and its role in pulmonary hypertension (2020) (0)
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- Impaired FGF10 Signaling Is Involved in the Development of Pulmonary Parenchymal and Vascular Remodeling (2022) (0)
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- Role of Reactive Oxygen Species in Acute Pulmonary Oxygen Sensing (2010) (0)
- Cell-specific Noxo1 Deletion in a Mouse Model of Cigarette Smoke-induced Emphysema and Pulmonary Hypertension (2023) (0)
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- Mitochondrial Respiration And Reactive Oxygen Species In Acute Pulmonary Oxygen Sensing Of Pulmonary Arterial Smooth Muscle Cells (2010) (0)
- Anti-fibrotic effects of pirfenidone on pulmonary arterial vascular smooth muscle cells (2016) (0)
- Effects of Multikinase inhibitors on pressure overload-induced right ventricular remodelling (2013) (0)
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- Abstract 15100: Inhibition of P38 Mapk Improves Heart Function in Sustained Pressure-overload Induced Right Ventricular Hypertrophy and Failure (2014) (0)
- A Possible Role Of Serotonin For The Development Of Tobacco-Smoke Induced Lung Emphysema And Pulmonary Hypertension (2012) (0)
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- Advances in the Treatment of Pulmonary Arterial Hypertension (2007) (0)
- iNOS Deletion in Alveolar Epithelium Cannot Reverse the Elastase-Induced Emphysema in Mice (2022) (0)
- Abstract 10916: Blocking MicroRNA-17 by Intravenous Injection of Antagomirs Improves Pulmonary Hemodynamics and Right Heart Function in Experimental Pulmonary Hypertension (2010) (0)
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- Axl is a Novel Modulator of Bone Morphogenetic Protein Receptor 2 in pulmonary arterial hypertension (2021) (0)
- Screening for biomarkers in pulmonary hypertension (2012) (0)
- Role of Hypoxia Inducible Factor (HIF) and NADPH oxidases in regulation of Kv channels in pulmonary artery smooth muscle cells (2008) (0)
- PDGF and Src tyrosine kinases in pulmonary arterial smooth muscle cells: Effects of dasatinib and nilotinib on pulmonary vascular remodeling (2011) (0)
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- A possible role of serotonin for the development of tobacco smoke-induced lung emphysema and pulmonary hypertension (2014) (0)
- The Role of Mitochondrial Cytochrome Coxidase Subunit 4 Isoform 2 (Cox4i2) in Acute Pulmonary Oxygen Sensing (2022) (0)
- Uncoupling protein of Acanthamoeba castellanii mitochondria is activated by lipid peroxidation end product hydroxynonenal (2012) (0)
- Lipopolysaccharides Induce Radiotherapy Resistance in Non-Small Cell Lung Cancer Cell Lines – the Role of Protein Kinase-Activation (2018) (0)
- NO synthase isoforms are involved in the LPS-induced alteration of hypoxic vasoconstriction (2008) (0)
- Synergistic Effect Of Imatinib And Sildenafil On Amelioration Of Pulmonary Hypertension—Role Of Src Kinase And Glycogen Synthase Kinase-3{beta} (2010) (0)
- [ARDS: possible role of bacterial exotoxin]. (1992) (0)
- FHL-1 Is Dispensable for Pressure Overload-Induced Maladaptive Right Ventricular Remodeling and Dysfunction (2019) (0)
- Increased generation of reactive oxygen species in pulmonary arterial smooth muscle cells from monocrotaline-treated rats (2010) (0)
- Correction to: Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension (2022) (0)
- Lungengefäßerkrankungen (2008) (0)
- Inflammatory Mediator Generation Epithelial Cells : Impact on Signaling Events Antibody ) with Human Renal Tubular ( Classic Anti-Neutrophil Cytoplasmic Interaction of Antibodies to Proteinase 3 and Ulf (2002) (0)
- Role of microRNA 17/92 cluster and microRNA 21 in the pathogenesis of pulmonary hypertension - Novel therapeutic targets (2013) (0)
- articleEffects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice (2015) (0)
- Author Correction: NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD (2020) (0)
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What Schools Are Affiliated With Friedrich Grimminger?
Friedrich Grimminger is affiliated with the following schools:
