Fritjof Helmchen
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Neuroscience
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Biology
Fritjof Helmchen's Degrees
- PhD Neuroscience University of Zurich
- Masters Biology University of Zurich
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(Suggest an Edit or Addition)Fritjof Helmchen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo (2005) (4780)
- Deep tissue two-photon microscopy (2005) (3631)
- Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance (2015) (829)
- Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. (1998) (801)
- Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo (2004) (778)
- Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons. (1996) (596)
- A Miniature Head-Mounted Two-Photon Microscope High-Resolution Brain Imaging in Freely Moving Animals (2001) (562)
- Imaging input and output of neocortical networks in vivo. (2005) (490)
- Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo (2004) (463)
- Pre‐ and postsynaptic whole‐cell recordings in the medial nucleus of the trapezoid body of the rat. (1995) (438)
- In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons (1999) (380)
- Imaging cellular network dynamics in three dimensions using fast 3D laser scanning (2007) (362)
- High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision (2010) (322)
- Barrel cortex function (2013) (311)
- Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide‐field, full‐color imaging (2010) (304)
- Calcium dynamics associated with a single action potential in a CNS presynaptic terminal. (1997) (303)
- Rapid 3D light-sheet microscopy with a tunable lens. (2013) (280)
- Fast two-layer two-photon imaging of neuronal cell populations using an electrically tunable lens (2011) (279)
- Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex (2013) (278)
- Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke (2014) (275)
- Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo. (2008) (266)
- Spatial Organization of Neuronal Population Responses in Layer 2/3 of Rat Barrel Cortex (2007) (261)
- Miniaturized two-photon microscope based on a flexible coherent fiber bundle and a gradient-index lens objective. (2004) (256)
- High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision (2010) (246)
- Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo (1999) (242)
- Spatial profile of dendritic calcium transients evoked by action potentials in rat neocortical pyramidal neurones. (1995) (237)
- Supralinear Ca2+ Influx into Dendritic Tufts of Layer 2/3 Neocortical Pyramidal Neurons In Vitro and In Vivo (2003) (224)
- Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex (2012) (213)
- Live imaging of neurogenesis in the adult mouse hippocampus (2018) (212)
- In vivo calcium imaging of neural network function. (2007) (206)
- Background Synaptic Activity Is Sparse in Neocortex (2006) (192)
- Dendritic Spikes in Apical Dendrites of Neocortical Layer 2/3 Pyramidal Neurons (2007) (189)
- Optical Recording of Neuronal Activity with a Genetically-Encoded Calcium Indicator in Anesthetized and Freely Moving Mice (2010) (188)
- Reorganization of cortical population activity imaged throughout long-term sensory deprivation (2012) (183)
- New developments in multiphoton microscopy (2002) (161)
- Radially expanding transglial calcium waves in the intact cerebellum (2009) (146)
- Optical probing of neuronal ensemble activity (2009) (141)
- The mesoSPIM initiative – open-source light-sheet microscopes for imaging cleared tissue (2019) (132)
- Calcium indicator loading of neurons using single-cell electroporation (2007) (129)
- In vivo calcium imaging of circuit activity in cerebellar cortex. (2005) (129)
- Pathway-specific reorganization of projection neurons in somatosensory cortex during learning (2015) (128)
- Specific Early and Late Oddball-Evoked Responses in Excitatory and Inhibitory Neurons of Mouse Auditory Cortex (2015) (113)
- High-density multi-fiber photometry for studying large-scale brain circuit dynamics (2018) (112)
- Distortion-free delivery of nanojoule femtosecond pulses from a Ti:sapphire laser through a hollow-core photonic crystal fiber. (2004) (108)
- Boosting of Action Potential Backpropagation by Neocortical Network Activity In Vivo (2004) (100)
- Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex (2016) (97)
- Long-range population dynamics of anatomically defined neocortical networks (2016) (97)
- Inference of neuronal network spike dynamics and topology from calcium imaging data (2013) (96)
- Ca2+ imaging in the mammalian brain in vivo. (2002) (91)
- Miniaturization of Fluorescence Microscopes Using Fibre Optics (2002) (90)
- New angles on neuronal dendrites in vivo. (2007) (87)
- Steady or changing? Long-term monitoring of neuronal population activity (2013) (86)
- Behavioral Strategy Determines Frontal or Posterior Location of Short-Term Memory in Neocortex (2018) (84)
- Sindbis vector SINrep(nsP2S726): a tool for rapid heterologous expression with attenuated cytotoxicity in neurons (2004) (82)
- Distinct Functional Properties of Primary and Posteromedial Visual Area of Mouse Neocortex (2012) (82)
- Value-guided remapping of sensory cortex by lateral orbitofrontal cortex (2020) (80)
- Miniaturization of two-photon microscopy for imaging in freely moving animals. (2013) (77)
- The Challenge of Connecting the Dots in the B.R.A.I.N. (2013) (75)
- Functional Imaging of Dentate Granule Cells in the Adult Mouse Hippocampus (2016) (73)
- Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells (2016) (68)
- A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine (2019) (66)
- Competitive Calcium Binding: Implications for Dendritic Calcium Signaling (1998) (66)
- Enhanced two-photon excitation through optical fiber by single-mode propagation in a large core. (2002) (64)
- Tactile frequency discrimination is enhanced by circumventing neocortical adaptation (2014) (62)
- Layer-specific integration of locomotion and sensory information in mouse barrel cortex (2019) (60)
- In vivo Ca2+ imaging of dorsal horn neuronal populations in mouse spinal cord (2010) (56)
- A Sensitive Dynamic and Active Pixel Vision Sensor for Color or Neural Imaging Applications (2017) (55)
- Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging (2020) (55)
- Layer-Specific Refinement of Sensory Coding in Developing Mouse Barrel Cortex (2016) (54)
- A Miniature Head-Mounted Neurotechnique Two-Photon Microscope: High-Resolution Brain Imaging in Freely Moving Animals (2001) (53)
- Fiber-optic implant for simultaneous fluorescence-based calcium recordings and BOLD fMRI in mice (2018) (53)
- Chronic imaging of cortical sensory map dynamics using a genetically encoded calcium indicator (2012) (53)
- In vivo labeling of cortical astrocytes with sulforhodamine 101 (SR101). (2012) (52)
- Representation of visual scenes by local neuronal populations in layer 2/3 of mouse visual cortex (2011) (52)
- HelioScan: A software framework for controlling in vivo microscopy setups with high hardware flexibility, functional diversity and extendibility (2013) (52)
- Miniaturized selective plane illumination microscopy for high-contrast in vivo fluorescence imaging. (2010) (51)
- Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation (2017) (51)
- Nonlinear anisotropic diffusion filtering of three-dimensional image data from two-photon microscopy. (2004) (49)
- Enhanced fluorescence signal in nonlinear microscopy through supplementary fiber-optic light collection. (2009) (47)
- Online correction of licking‐induced brain motion during two‐photon imaging with a tunable lens (2013) (47)
- Postsynaptic Ca2+ Influx Mediated by Three Different Pathways during Synaptic Transmission at a Calyx-Type Synapse (1998) (47)
- Novel Approaches to Monitor and Manipulate Single Neurons In Vivo (2004) (46)
- A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging (2020) (45)
- Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response (2019) (43)
- Imaging in neuroscience : a laboratory manual (2011) (42)
- Neuron to Astrocyte Communication via Cannabinoid Receptors Is Necessary for Sustained Epileptiform Activity in Rat Hippocampus (2012) (39)
- Stimulus relevance modulates contrast adaptation in visual cortex (2016) (39)
- Calibration of fluorescent calcium indicators. (2011) (38)
- Chapter 10. In vivo measurements of blood flow and glial cell function with two-photon laser-scanning microscopy. (2008) (37)
- Two-photon imaging and analysis of neural network dynamics (2011) (35)
- Multiphoton in vivo imaging with a femtosecond semiconductor disk laser. (2017) (35)
- Spatiotemporal refinement of signal flow through association cortex during learning (2019) (33)
- A single-compartment model of calcium dynamics in nerve terminals and dendrites. (2015) (33)
- An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator (2017) (33)
- Dendrites as biochemical compartments (1999) (32)
- Calcium influx during an action potential. (1998) (31)
- Opto‐E‐Dura: A Soft, Stretchable ECoG Array for Multimodal, Multiscale Neuroscience (2020) (31)
- Cortical Excitation:Inhibition Imbalance Causes Abnormal Brain Network Dynamics as Observed in Neurodevelopmental Disorders (2018) (30)
- Two-photon imaging of spinal cord cellular networks (2013) (30)
- Nonlinear anisotropic diffusion filtering of three-dimensional image data from two-photon microscopy (2003) (30)
- Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors (2011) (28)
- In Vivo Measurements of Blood Flow and Glial Cell Function with Two-Photon Laser-Scanning Microscopy (2008) (27)
- Post hoc immunostaining of GABAergic neuronal subtypes following in vivo two-photon calcium imaging in mouse neocortex (2011) (27)
- Sensory and Behavioral Components of Neocortical Signal Flow in Discrimination Tasks with Short-Term Memory (2020) (27)
- Sparse, reliable, and long-term stable representation of periodic whisker deflections in the mouse barrel cortex (2015) (25)
- Microcircuit dynamics of map plasticity in barrel cortex (2014) (24)
- Selective Regulation of NR2B by Protein Phosphatase-1 for the Control of the NMDA Receptor in Neuroprotection (2012) (23)
- Raising the speed limit – fast Ca2+ handling in dendritic spines (2002) (22)
- Model-based analysis of pattern motion processing in mouse primary visual cortex (2015) (22)
- In vivo Ca 2 + imaging of dorsal horn neuronal populations in mouse spinal cord (2010) (22)
- Representation of Thermal Information in the Antennal Lobe of Leaf-Cutting Ants (2010) (21)
- Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes (2021) (20)
- Context-dependent limb movement encoding in neuronal populations of motor cortex (2019) (20)
- Activity in a Premotor Cortical Nucleus of Zebra Finches Is Locally Organized and Exhibits Auditory Selectivity in Neurons but Not in Glia (2013) (20)
- Whole brain optoacoustic tomography reveals strain-specific regional beta-amyloid densities in Alzheimer’s disease amyloidosis models (2020) (18)
- Tissue Clearing and Light Sheet Microscopy: Imaging the Unsectioned Adult Zebra Finch Brain at Cellular Resolution (2019) (18)
- iDISCO+ for the Study of Neuroimmune Architecture of the Rat Auditory Brainstem (2019) (17)
- Two-Photon Functional Imaging of Neuronal Activity (2009) (17)
- A modular two-photon microscope for simultaneous imaging of distant cortical areas in vivo (2015) (16)
- Neocortical Dynamics During Whisker-Based Sensory Discrimination in Head-Restrained Mice (2018) (15)
- Biochemical compartmentalization in dendrites (2007) (14)
- Corrigendum: Deep tissue two-photon microscopy (2006) (14)
- The mesoSPIM initiative: open-source light-sheet mesoscopes for imaging in cleared tissue (2019) (14)
- Optical Imaging of Neocortical Dynamics (2014) (13)
- Correction: Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes (2020) (13)
- Molecular Supralinear Ca 2 Influx into Dendritic Tufts of Layer 2 / 3 Neocortical Pyramidal Neurons In Vitro and In Vivo (2003) (13)
- Developmental divergence of sensory stimulus representation in cortical interneurons (2020) (13)
- High-speed two-photon calcium imaging of neuronal population activity using acousto-optic deflectors. (2014) (10)
- Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier (2018) (10)
- Sensory representation of an auditory cued tactile stimulus in the posterior parietal cortex of the mouse (2018) (10)
- Calibration protocols for fluorescent calcium indicators. (2011) (9)
- In Vivo Calcium Imaging of CA3 Pyramidal Neuron Populations in Adult Mouse Hippocampus (2021) (9)
- Unsupervised behaviour analysis and magnification (uBAM) using deep learning (2021) (8)
- Functional Architecture and Encoding of Tactile Sensorimotor Behavior in Rat Posterior Parietal Cortex (2019) (8)
- Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice (2022) (8)
- Deep learning is widely applicable to phenotyping embryonic development and disease (2021) (8)
- In-vivo imaging of neural activity with dynamic vision sensors (2017) (7)
- In-Depth Characterization of Layer 5 Output Neurons of the Primary Somatosensory Cortex Innervating the Mouse Dorsal Spinal Cord (2020) (7)
- Synaptic inhibition in the lateral habenula shapes reward anticipation (2021) (7)
- Chronic Two-Photon Imaging of Neural Activity in the Anesthetized and Awake Behaving Rodent (2014) (6)
- Conservation laws by virtue of scale symmetries in neural systems (2020) (6)
- Layer-specific integration of locomotion and concurrent wall touching in mouse barrel cortex (2018) (6)
- Temporal refinement of sensory‐evoked activity across layers in developing mouse barrel cortex (2019) (6)
- Cortical excitation:inhibition imbalance causes network-specific functional hypoconnectivity: a DREADD-fMRI study (2018) (5)
- Measuring neuronal population activity using 3D laser scanning. (2011) (5)
- Isotropic imaging across spatial scales with axially swept light-sheet microscopy (2021) (5)
- Basomedial amygdala activity in mice reflects specific and general aversion uncontrollability (2020) (5)
- Two-Photon Imaging of Neuronal Network Dynamics in Neocortex (2014) (5)
- Dendritic integration of sensory and reward information facilitates learning (2021) (5)
- Spatiotemporal refinement of signal flow through association cortex during learning (2020) (4)
- New views into the brain of mice on the move (2008) (4)
- 3D Reconstruction of the Clarified Rat Hindbrain Choroid Plexus (2021) (4)
- Neural Systems Under Change of Scale (2021) (4)
- Specific excitatory connectivity for feature integration in mouse primary visual cortex (2017) (4)
- Axel Nimmerjahn Parenchyma in Vivo Resting Microglial Cells Are Highly Dynamic Surveillants of Brain (2013) (3)
- Value-guided remapping of sensory circuits by lateral orbitofrontal cortex in reversal learning (2020) (3)
- 4.39 – Action Potentials in Dendrites and Spike-Timing-Dependent Plasticity (2008) (3)
- uBAM: Unsupervised Behavior Analysis and Magnification using Deep Learning (2020) (3)
- Striatum-projecting prefrontal cortex neurons support working memory maintenance (2021) (3)
- Dendritic Branch-constrained N-Methyl-d-Aspartate Receptor-mediated Spikes Drive Synaptic Plasticity in Hippocampal CA3 Pyramidal Cells (2021) (3)
- A single compartment model of calcium dynamics in dendrites and nerve terminals (2011) (3)
- Dynamic reorganization of the cortico-basal ganglia-thalamo-cortical network during task learning (2022) (3)
- Network constraints in scale free dynamical systems. (2019) (3)
- , Surveillants of Brain Parenchyma in Vivo Resting Microglial Cells Are Highly Dynamic (2010) (2)
- Opto-E-Dura: a Soft, Stretchable ECoG Array for Multimodal, Multi-scale Neuroscience (2020) (2)
- Mesoscale brain dynamics reorganizes and stabilizes during learning (2020) (2)
- Centripetal integration of past events by hippocampal astrocytes (2022) (2)
- Imaging and analysis of neural network dynamics (2011) (1)
- Conditional genetic labeling of the Renshaw cell population for functional studies of motor control (2009) (1)
- Optogenetic analysis of mammalian neural circuits (2013) (1)
- Little Strokes Fill Big Oaks: A Simple In Vivo Stain of Brain Cells (2007) (1)
- Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies (2022) (1)
- Handbook of Neural Activity Measurement: Calcium imaging (2012) (1)
- Value-guided remapping of sensory cortex (2021) (1)
- Reflective multi-immersion microscope objectives inspired by the Schmidt telescope (2022) (1)
- Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus (2023) (1)
- Innovative Methodology New Angles on Neuronal Dendrites In Vivo (2007) (1)
- Nigral Dopamine Neurons Endogenous Calcium Buffering Capacity of Substantia (2015) (0)
- Erratum: Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex (Proceedings of the National Academy of Sciences of the United States of America (December 22, 1998)) (1999) (0)
- Behavioral and Multi-Photon Analysis of Plaid Stimulus Integration in the Zebrafish Visual Tectum (2008) (0)
- EXPLORE: a novel deep learning-based analysis method for exploration behaviour in object recognition tests (2022) (0)
- Population activity induced in the hippocampal network (2006) (0)
- Live demonstration: In-vivo imaging of neural activity with dynamic vision sensors (2017) (0)
- Behavior-relevant top-down cross-modal predictions in mouse neocortex (2023) (0)
- Editorial Board (2013) (0)
- Automated whole organ imaging using open source tools (2019) (0)
- TWO-PHOTON MICROSCOPY OF NEURAL NETWORK FUNCTION (2011) (0)
- High-density multi-fiber photometry for studying large-scale brain circuit dynamics (2019) (0)
- Distinct hypothalamus-habenula circuits govern risk preference (2023) (0)
- Post hoc immunostaining of GABAergic neuronal subtypes following in vivo two-photon calcium imaging in mouse neocortex (2011) (0)
- Ultrafast semiconductor disk lasers for in vivo multiphoton imaging (2017) (0)
- Imaging the Cortical Representation of Active Sensing in the Vibrissa System (2015) (0)
- Estimating anisotropy directly via neural timeseries (2021) (0)
- In vivo FM: using conventional fluorescence microscopy to monitor retinal neuronal death in vivo (2002) (0)
- FAST 3D 2-PHOTON CALCIUM IMAGING IN THE ANTENNAL LOBE OF DROSOPHILA (2011) (0)
- Analogous cognitive strategies for tactile learning in the rodent and human brain (2023) (0)
- Conservative significance testing of tripartite statistical relations in multivariate neural data (2022) (0)
- Scaling conservation laws in neural systems (2020) (0)
- Neuronal networks in the spotlight (2013) (0)
- Imaging of localized neuronal calcium influx (2001) (0)
- Three-dimensional imaging of neuronal network activity (2011) (0)
- Whole-mouse clearing and imaging at the cellular level with vDISCO (2023) (0)
- Neocortex in the Spotlight: Concepts, Questions, and Methods (2014) (0)
- Sensory representation of an auditory cued tactile stimulus in the posterior parietal cortex of the mouse (2018) (0)
- Quantitative 3D microscopy reveals a genetic network predicting the local activity of anti-Aβ compounds (2021) (0)
- Viral expression of Yellow cameleon 3.60 allows optical single-spike detection using two-photon imaging in vivo (2009) (0)
- Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation (2017) (0)
- Fiber-optic two-photon-excited fluorescence microscopy (2004) (0)
- Multiphoton microscopy in every lab: the promise of ultrafast semiconductor disk lasers (2017) (0)
- Author response: Long-range population dynamics of anatomically defined neocortical networks (2016) (0)
- Author Correction: A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine (2021) (0)
- Layer-specific integration of locomotion and sensory information in mouse barrel cortex (2019) (0)
- Femtosecond semiconductor disk lasers: a promising tool for the future of multiphoton imaging (2018) (0)
- The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue (2019) (0)
- Introduction Calibration of Fluorescent Calcium Indicators (2011) (0)
- Sensory representation of a cued tactile stimulus in the posterior parietal cortex of the mouse (2017) (0)
- Chapter 321 – In Vivo Imaging of Cellular Network Signaling (2010) (0)
- A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine (2019) (0)
- In vivo calcium imaging of information processing in mouse neocortex during behavior (2015) (0)
- History information emerges in the cortex during learning (2022) (0)
- Stimulus reconstruction from in vivo spiking activity of neuronal populations in somatosensory cortex (2007) (0)
- Local predictors of anti-Aβ therapy efficacy revealed by quantitative whole-brain microscopy (2021) (0)
- Estimating quantities conserved by virtue of scale invariance in timeseries (2019) (0)
- in vivoFrom The Cover : Imaging input and output of neocortical networks (2005) (0)
- Animals Miniaturization of Two-Photon Microscopy for Imaging in Freely Moving (2014) (0)
- Reflective multi-immersion microscope objectives (2023) (0)
- Conservative Significance Testing of Tripartite Interactions in Multivariate Neural Data (2022) (0)
- Longitudinal quantitative whole-brain microscopy reveals distinct temporal and spatial efficacies of anti-Aβ therapies (2022) (0)
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