Frits Koning

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Frits Koning

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Philosophy

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PhD Immunology Leiden University
Masters Biology Leiden University

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Frits Koning's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The Intestinal T Cell Response to α-Gliadin in Adult Celiac Disease Is Focused on a Single Deamidated Glutamine Targeted by Tissue Transglutaminase (2000) (682)
Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study (2010) (597)
Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid (1989) (545)
Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. (1998) (518)
Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes (2006) (494)
Identification of a graft versus host disease-associated human minor histocompatibility antigen. (1995) (439)
The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. (2002) (432)
Randomized feeding intervention in infants at high risk for celiac disease. (2014) (401)
Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules (2012) (392)
Specificity of Tissue Transglutaminase Explains Cereal Toxicity in Celiac Disease (2002) (380)
The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses (2003) (361)
Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. (2006) (285)
The Molecular Basis for Oat Intolerance in Patients with Celiac Disease (2004) (283)
Mannose receptor‐mediated uptake of antigens strongly enhances HLA class II‐restricted antigen presentation by cultured dendritic cells (1997) (278)
Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin. (1998) (270)
Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. (2005) (250)
T Cell Responses Modulated Through Interaction Between CD8αα and the Nonclassical MHC Class I Molecule, TL (2001) (250)
Characterization of cereal toxicity for celiac disease patients based on protein homology in grains. (2003) (250)
Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease (2007) (248)
Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94. (1996) (243)
Narcolepsy — clinical spectrum, aetiopathophysiology, diagnosis and treatment (2019) (239)
Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. (2002) (215)
The Ethiopian cereal tef in celiac disease. (2005) (214)
Glutenin is involved in the gluten‐driven mucosal T cell response (1999) (214)
The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. (2005) (210)
Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. (1988) (186)
Identification of a T3-associated gamma delta T cell receptor on Thy-1+ dendritic epidermal Cell lines. (1987) (178)
Specific recognition of staphylococcal enterotoxin A by human T cells bearing receptors with the Vγ9 region (1990) (175)
Celiac disease: how complicated can it get? (2010) (174)
Visual analysis of mass cytometry data by hierarchical stochastic neighbour embedding reveals rare cell types (2017) (173)
Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor (1990) (165)
T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease (2014) (160)
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants (2006) (158)
Thy-1+ dendritic epidermal cells express T3 antigen and the T-cell receptor gamma chain. (1987) (158)
Celiac disease--sandwiched between innate and adaptive immunity. (2006) (150)
Guidance on allergenicity assessment of genetically modified plants (2017) (141)
A New Type of Metal Recognition by Human T Cells (2003) (140)
The implications of subunit interactions for the structure of the T cell receptor‐CD3 complex (1990) (132)
Celiac disease: caught between a rock and a hard place. (2005) (130)
Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease. (2012) (125)
Mannose receptor mediated uptake of antigens strongly enhances HLA-class II restricted antigen presentation by cultured dendritic cells. (1997) (118)
CD14 contributes to the adherence of human monocytes to cytokine-stimulated endothelial cells. (1991) (111)
Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets. (2016) (110)
Consumption of gluten with gluten-degrading enzyme by celiac patients: a pilot-study. (2013) (108)
Intratumoral HPV16-Specific T Cells Constitute a Type I–Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer (2017) (108)
Cytosplore: Interactive Immune Cell Phenotyping for Large Single‐Cell Datasets (2016) (105)
Memory CD4+ T cells are generated in the human fetal intestine (2018) (100)
Update 2020: nomenclature and listing of celiac disease–relevant gluten epitopes recognized by CD4+ T cells (2019) (98)
An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients (2003) (98)
Dual HLA class I and class II restricted recognition of alloreactive T lymphocytes mediated by a single T cell receptor complex (2001) (97)
Peptide binding characteristics of the coeliac disease-associated DQ(α1*0501, β1*0201) molecule (2007) (96)
A mouse monoclonal antibody detecting a DR-related MT2-like specificity: serology and biochemistry. (1984) (94)
Unique peptide binding characteristics of the disease-associated DQ(α1*0501, β1*0201) vs the non-disease-associated DQ(α1*0201, β1*0202) molecule (1997) (92)
The role of HLA-DQ8 β57 polymorphism in the anti-gluten T-cell response in coeliac disease (2008) (88)
T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. (2001) (88)
The PreventCD Study design: towards new strategies for the prevention of coeliac disease (2010) (83)
Large-Scale Characterization of Natural Ligands Explains the Unique Gluten-Binding Properties of HLA-DQ21 (2008) (82)
Phenotypic and Functional Characterization of CD4 T Cells Expressing Killer Ig-Like Receptors1 (2004) (80)
A 40-Marker Panel for High Dimensional Characterization of Cancer Immune Microenvironments by Imaging Mass Cytometry (2019) (77)
Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP. (1997) (77)
Interplay between genetics and the environment in the development of celiac disease: perspectives for a healthy life. (2001) (76)
Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance. (2014) (74)
Morphological changes during dendritic cell maturation correlate with cofilin activation and translocation to the cell membrane (2004) (74)
A Universal Approach to Eliminate Antigenic Properties of Alpha-Gliadin Peptides in Celiac Disease (2010) (74)
Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis (2015) (73)
High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity (2019) (72)
DRB1*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles. (1992) (72)
Induction of Antigen-Specific Tolerance by Oral Administration of Lactococcus lactis Delivered Immunodominant DQ8-Restricted Gliadin Peptide in Sensitized Nonobese Diabetic Ab° Dq8 Transgenic Mice1 (2009) (72)
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease (2019) (71)
Tef in the diet of celiac patients in The Netherlands (2008) (70)
Type 1 Diabetes-associated HLA-DQ8 Transdimer Accommodates a Unique Peptide Repertoire* (2011) (68)
Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules (1999) (67)
KIR‐Ligand Mismatches Are Associated With Reduced Long‐Term Graft Survival in HLA‐Compatible Kidney Transplantation (2011) (65)
The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice (2015) (63)
Phenotypical and Functional Characterization of Small Intestinal TcRγδ+ T Cells in Coeliac Disease (1992) (61)
Characterization of T cell receptors on resident murine dendritic epidermal T cells (1988) (61)
Human dendritic cells shed a functional, soluble form of the mannose receptor. (1999) (60)
A novel and sensitive method for the detection of T cell stimulatory epitopes of α/β- and γ-gliadin (2004) (60)
AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz (2010) (59)
Structure of celiac disease-associated HLA-DQ8 and non-associated HLA-DQ9 alleles in complex with two disease-specific epitopes. (2000) (59)
Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with celiac disease. (2008) (58)
Celiac disease: quantity matters (2012) (58)
Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine (2018) (58)
Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II (2012) (57)
High expression of V gamma 8 is a shared feature of human gamma delta T cells in the epithelium of the gut and in the inflamed synovial tissue. (1994) (57)
T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1 (2005) (57)
Murine T cells express a cell surface receptor for multiple extracellular matrix proteins. Identification and characterization with monoclonal antibodies (1989) (57)
Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells. (2011) (56)
Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens (2015) (55)
Randomised clinical study: Aspergillus niger‐derived enzyme digests gluten in the stomach of healthy volunteers (2015) (54)
Gluten: a two-edged sword. Immunopathogenesis of celiac disease (2005) (54)
T90/44 (9.3 antigen). A cell surface molecule with a function in human T cell activation (1986) (53)
Get into the groove! Targeting antigens to MHC class II (1999) (52)
Determinants of Gliadin-Specific T Cell Selection in Celiac Disease (2015) (50)
Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation (2012) (49)
Gluten-Specific T Cells Cross-React between HLA-DQ8 and the HLA-DQ2α/DQ8β Transdimer (2011) (49)
Design, synthesis and evaluation of high-affinity binders for the celiac disease associated HLA-DQ2 molecule. (2010) (49)
Identification of a Novel Tumor-Specific CTL Epitope Presented by RMA, EL-4, and MBL-2 Lymphomas Reveals Their Common Origin (2000) (49)
Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor gamma delta structures. (1988) (49)
Fine specificity of monoclonal antibodies against celiac disease-inducing peptides in the gluteome. (2008) (46)
The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose (2018) (46)
Dissection of the HLA-DR4 Peptide Repertoire in Endocrine Epithelial Cells: Strong Influence of Invariant Chain and HLA-DM Expression on the Nature of Ligands1 (2004) (46)
ImaCytE: Visual Exploration of Cellular Micro-Environments for Imaging Mass Cytometry Data (2021) (46)
Coeliac disease and gluten-related disorders in childhood (2015) (46)
Origin and immunophenotype of aberrant IEL in RCDII patients. (2012) (45)
Natural peptides isolated from Gly86/Val86-containing variants of HLA-DR1,-DR 11, -DR13, and -DR52 (2005) (45)
Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution. (2016) (45)
Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma. (2008) (44)
Microbial transglutaminases generate T cell stimulatory epitopes involved in celiac disease (2008) (44)
Functional human epidermal Langerhans cells that lack Birbeck granules. (1994) (44)
Analysis of the donor-specific cytotoxic T lymphocyte repertoire in a patient with a long term surviving allograft. Frequency, specificity, and phenotype of donor-reactive T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ clones. (1990) (43)
Distribution of HLA class II molecules in epidermal Langerhans cells in situ (1995) (42)
Functional Killer Ig-Like Receptors on Human Memory CD4+ T Cells Specific for Cytomegalovirus1 (2009) (41)
Ineffective Degradation of Immunogenic Gluten Epitopes by Currently Available Digestive Enzyme Supplements (2015) (41)
A Leishmania homologue of receptors for activated C-kinase (LACK) induces both interferon-gamma and interleukin-10 in natural killer cells of healthy blood donors. (2000) (41)
Peptide binding characteristics of the coeliac disease-associated DQ(alpha1*0501, beta1*0201) molecule. (1996) (41)
CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes (2017) (40)
PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors (2019) (40)
HLA-DR4 Molecules in Neuroendocrine Epithelial Cells Associate to a Heterogeneous Repertoire of Cytoplasmic and Surface Self Peptides1 (2002) (38)
A monoclonal antibody detecting an HLA-DQwl-related determinant. (2008) (38)
TA10 and 2B3, two new alleles in the HLA-DQ region recognized by monoclonal antibodies. (1986) (38)
Strongly increased efficiency of altered peptide ligands by mannosylation. (1998) (37)
HLA class II expression on human epidermal Langerhans cells in situ: upregulation during the elicitation of allergic contact dermatitis. (1992) (36)
Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity (2020) (36)
Phenotypical heterogeneity among human t cell receptor γ/δ‐expressing clones derived from peripheral blood (1989) (36)
DR4Dw4/DR53 molecules contain a peptide from the autoantigen calreticulin. (1995) (36)
A Subset of Vδ1+ T Cells Proliferates in Response to Epstein‐Barr Virus‐Transformed B Cell Lines In Vitro (1993) (35)
Functional and molecular characterization of B cell‐responsive Vδ1+ γδ T cells (1994) (35)
Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library. (2010) (35)
Predicting Cell Populations in Single Cell Mass Cytometry Data (2019) (34)
Gluten tolerance in adult patients with celiac disease 20 years after diagnosis? (2008) (34)
HLA‐DRβ chain residue 86 controls DRαβ dimer stability (1993) (34)
Influence of dietary components on Aspergillus niger prolyl endoprotease mediated gluten degradation. (2015) (34)
Impact of Peptides on the Recognition of HLA Class I Molecules by Human HLA Antibodies (2003) (34)
The biosynthesis and assembly of T cell receptor alpha- and beta-chains with the CD3 complex. (1988) (34)
Identification of an HLA‐DQ2 peptide binding motif and HLA‐DPw3‐bound self‐peptide by pool sequencing (1994) (33)
Structural comparison of α/β and γ/δ T cell receptor‐CD3 complexes reveals identical subunit interactions but distinct cross‐linking patterns of T cell receptor chains (1990) (32)
Independent association of T cell receptor beta and gamma chains with CD3 in the same cell (1987) (32)
Coeliac disease: it takes three to tango! (2000) (32)
A novel and sensitive method for the detection of T cell stimulatory epitopes of alpha/beta- and gamma-gliadin. (2004) (32)
Weight loss induced by very low calorie diet is associated with a more beneficial systemic inflammatory profile than by Roux-en-Y gastric bypass. (2016) (32)
The molecular basis of celiac disease (2003) (31)
Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens (2019) (31)
The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease (2015) (30)
Coordinated Vγ and Vδ gene segment rearrangements in human T cell receptor γ/δ+ lymphocytes (1989) (30)
Evidence for natural killer cell-mediated protection from metastasis formation in uveal melanoma patients. (2009) (29)
Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies (2020) (29)
Unique peptide binding characteristics of the disease-associated DQ(alpha 1*0501, beta 1*0201) vs the non-disease-associated DQ(alpha 1*0201, beta 1*0202) molecule. (1997) (28)
The generation of SDS-stable HLA DR dimers is independent of efficient peptide binding. (1996) (28)
The Probiotic Mixture VSL#3 Has Differential Effects on Intestinal Immune Parameters in Healthy Female BALB/c and C57BL/6 Mice. (2015) (28)
Gene Expression Profiling Identifies Mechanisms of Protection to Recurrent Trinitrobenzene Sulfonic Acid Colitis Mediated by Probiotics (2012) (28)
Soluble mannosylated myelin peptide inhibits the encephalitogenicity of autoreactive T cells during experimental autoimmune encephalomyelitis. (2007) (27)
Local communication among mucosal immune cells in patients with celiac disease. (2015) (27)
Molecular localization of LB-Q1, a DRw52-like T-cell recognition epitope and identification at the genomic level of associated shared hybridizing fragments. (1987) (27)
Validation of a new enzyme-linked immunosorbent assay to detect the triggering proteins and peptides for celiac disease: interlaboratory study. (2012) (26)
The tortoise and the hare: slowly evolving T‐cell responses take hastily evolving KIR (2010) (26)
Human suppressor T cell clones lack CD28 (1990) (26)
Chronic schistosomiasis: dendritic cells generated from patients can overcome antigen-specific T cell hyporesponsiveness. (2000) (25)
Advancing human health risk assessment (2019) (25)
γδ T cell reactivity towards bacterial superantigens (1993) (25)
Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect (2009) (24)
Natural variation in avenin epitopes among oat varieties: Implications for celiac disease (2011) (24)
Phenotypical and functional characterization of small intestinal TcR gamma delta + T cells in coeliac disease. (1992) (24)
Mannosylated PLP139–151 induces peptide-specific tolerance to experimental autoimmune encephalomyelitis (2005) (24)
Adipocyte telomere length associates negatively with adipocyte size, whereas adipose tissue telomere length associates negatively with the extent of fibrosis in severely obese women (2014) (23)
Helminth infections drive heterogeneity in human type 2 and regulatory cells (2020) (22)
CyteGuide: Visual Guidance for Hierarchical Single-Cell Analysis (2018) (22)
Expression of C gamma 4 T cell receptors and lack of isotype exclusion by dendritic epidermal T cell lines. (1988) (22)
Abrogation of Immunogenic Properties of Gliadin Peptides through Transamidation by Microbial Transglutaminase Is Acyl-Acceptor Dependent (2017) (21)
An Arthritis‐Suppressive and Treg Cell–Inducing CD4+ T Cell Epitope Is Functional in the Context of HLA‐Restricted T Cell Responses (2016) (20)
DNAM-1 Mediates Epithelial Cell-Specific Cytotoxicity of Aberrant Intraepithelial Lymphocyte Lines from Refractory Celiac Disease Type II Patients (2011) (20)
Screening for unrecognized coeliac disease in subfertile couples (2011) (20)
Isolation of an HLA‐A2.1 extracted human minor histocompatibility peptide (1993) (20)
Superior tumor protection induced by a cellular vaccine carrying a tumor-specific T helper epitope by genetic exchange of the class II-associated invariant chain peptide. (2000) (19)
A 34-Marker Panel for Imaging Mass Cytometric Analysis of Human Snap-Frozen Tissue (2020) (19)
Adverse Effects of Wheat Gluten (2015) (19)
Ia molecular localization of the DRw52 allodeterminant and the DRw52-like determinants defined by monoclonal antibodies. (1985) (19)
Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 molecule (2008) (19)
Expression of the human T cell receptor as defined by anti-isotypic antibodies. (1987) (18)
Induction of Antigen-Specific Tolerance by Oral Administration of Lactococcus lactis Delivered Immunodominant DQ8-Restricted Gliadin Peptide in Sensitized Nonobese Diabetic Ab Dq8 Transgenic Mice (2009) (18)
Expansion of large granular lymphocytes in IL-2-driven 14-day-old fetal thymocytes in organ culture. (1990) (18)
Pathophysiology of Celiac Disease (2014) (18)
The Probiotic Mixture VSL#3 Dampens LPS-Induced Chemokine Expression in Human Dendritic Cells by Inhibition of STAT-1 Phosphorylation (2014) (18)
Selective outgrowth of CD45RO+ V gamma 9+/V delta 2+ T-cell receptor gamma/delta T cells early after bone marrow transplantation. (1991) (17)
CyTOFmerge: integrating mass cytometry data across multiple panels (2019) (17)
HLA Reduces Killer Cell Ig-like Receptor Expression Level and Frequency in a Humanized Mouse Model (2013) (17)
No genetic association of the human prolyl endopeptidase gene in the Dutch celiac disease population. (2005) (17)
HLA class II restriction repertoire of antigen-specific T cells. II. Evidence for a new restriction determinant associated with DRw52 and LB-Q1. (1985) (16)
Gluten Peptides and Celiac Disease (2003) (15)
Enzymatic gluten detoxification: the proof of the pudding is in the eating! (2006) (15)
Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry (2019) (15)
H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls (2019) (15)
Reactivity of Human γδ T Cells to Staphylococcal Enterotoxins: a Restricted Reaction Pattern mediated by Two Distinct Recognition Pathways (1993) (15)
Mannosylated PLP(139-151) induces peptide-specific tolerance to experimental autoimmune encephalomyelitis. (2005) (15)
Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer (1987) (15)
379 Can Prolyl Endoprotease Enzyme Treatment Mitigate the Toxic Effect of Gluten in Coeliac Patients (2010) (15)
Multiple epitopes on a single DQ molecule from the DQw3-carrying haplotypes. (2008) (15)
Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity (2021) (15)
Induction of antigen specific CD4+ T cell responses by invariant chain based DNA vaccines. (2001) (15)
CD4‐independent T cells impair TCR triggering of CD4‐dependent T cells: a putative mechanism for T cell affinity maturation (2001) (14)
The probiotic mixture VSL#3 mediates both pro- and anti-inflammatory responses in bone marrow-derived dendritic cells from C57BL/6 and BALB/c mice (2014) (14)
Immunization with mannosylated peptide induces poor T cell effector functions despite enhanced antigen presentation. (2008) (14)
Best Abstracts (2004) (14)
HLA-DR beta chain residue 86 controls DR alpha beta dimer stability. (1993) (14)
Safety Assessment of Immune-Mediated Adverse Reactions to Novel Food Proteins. (2019) (14)
Altered peptide ligands and wild‐type peptide induce indistinguishable responses of a human Th0 clone (1998) (14)
Development and in-house validation of a competitive ELISA for the quantitative detection of gluten in food (2017) (14)
Allergenicity Assessment of Novel Food Proteins: What Should Be Improved? (2020) (13)
Severe combined immunodeficiency in man with an absence of immunoglobulin gene rearrangements but normal T cell receptor assembly (1990) (13)
Visualizing Dynamic Changes at the Maternal-Fetal Interface Throughout Human Pregnancy by Mass Cytometry (2020) (13)
Staphylococcal enterotoxin-mediated human T-T cell interactions. (1992) (13)
An improved RT-PCR method for the detection of killer-cell immunoglobulin-like receptor (KIR) transcripts (2006) (13)
A subset of V delta 1+ T cells proliferates in response to Epstein-Barr virus-transformed B cell lines in vitro. (1993) (12)
Lactobacillus plantarum NCIMB8826 ameliorates inflammation of colon and skin in human APOC1 transgenic mice. (2016) (12)
Lymphocyte antigen receptors: a common design? (1991) (12)
The gamma delta T cell receptor. (1989) (12)
Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease (2021) (12)
Cutting Edge: Killer Ig-Like Receptors Mediate “Missing Self” Recognition In Vivo1 (2009) (11)
Successful treatment of coeliac disease by allogeneic haematopoietic stem cell transplantation. (2010) (11)
Hybrid Imaging Labels: Providing the Link Between Mass Spectrometry-Based Molecular Pathology and Theranostics (2017) (11)
Phenotypical and functional analysis of B lymphocytes of two siblings with combined immunodeficiency and defective expression of major histocompatibility complex (MHC) class II antigens on mononuclear cells (1987) (11)
Tissue transglutaminase: master regulator of celiac disease? (2003) (11)
Definition of agonists and design of antagonists for alloreactive T cell clones using synthetic peptide libraries. (1999) (11)
Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer (2020) (10)
Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells (2003) (10)
Increased HLA-DQ2-affinity of a synthetic gliadin peptide by acid-induced deamidation of glutamine residues. (1998) (9)
Anti-alpha-gliadin antibodies (AGA) in the serum of coeliac children and controls recognize an identical collection of linear epitopes of alpha-gliadin. (1998) (9)
γδ T cells are effectors of immunotherapy in cancers with HLA class I defects (2023) (9)
Celiac Disease: Past, Present, and Future Challenges Dedicated to the Memory of Our Friend and Colleague, Prof David Branski (1944–2013) (2014) (9)
The Impact of Single Amino Acid Substitutions in CD3γ on the CD3ϵγ Interaction and T-Cell Receptor–CD3 Complex Formation (2006) (9)
A Specialist Macaque MHC Class I Molecule with HLA-B*27–like Peptide-Binding Characteristics (2017) (9)
Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-γ-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance (2016) (9)
Functional and molecular characterization of B cell-responsive V delta 1+ gamma delta T cells. (1994) (9)
Therapy in RCDII: Rationale for Combination Strategies? (2015) (8)
Genetic and functional analysis of pyroglutamyl-peptidase I in coeliac disease (2006) (8)
FcRγ‐chain deficiency reduces the development of diet‐induced obesity (2015) (8)
Expression of CD11, CDw15, and transferrin receptor antigens on human hematopoietic progenitor cells. (1986) (8)
Right on target: Novel approaches for the direct visualization of CD1-specific T cell responses (2001) (8)
Intolerance of celiac disease patients to bovine milk is not due to the presence of T-cell stimulatory epitopes of gluten. (2009) (8)
Recent insight in the pathophysiology of coeliac disease: relevance to rheumatoid arthritis. (2015) (8)
Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface (2022) (8)
Enhancement of HLA class II restricted antigen presentation by mannose-receptor-mediated uptake. (1997) (7)
Antibody dependent cellular cytotoxicity mediated by HLA-class II specific monoclonal antibodies. (2008) (7)
Dendritic cells promote expansion and survival of aberrant TCR-negative intraepithelial lymphocyte lines from refractory celiac disease type II patients. (2014) (7)
TCR γδ cells: Antigen-driven expansion of distinct subsets based on localization and antigen specificity (1991) (7)
Celiac Disease: Across the Threshold of Tolerance (2008) (7)
γδ T-cell receptor repertoire in human peripheral blood and thymus (2005) (7)
Differential Expression of DRw52‐Like Determinants Detected by Monoclonal Antibodies (1987) (7)
Food -related strategies towards reduction of gluten intolerance and gluten sensitivity (2011) (7)
T cells from the small intestinal mucosa of coeliac disease patients recognise a unique peptide sequence of gliadin (1998) (7)
Immobilized staphylococcal enterotoxin A is sufficient to induce T cell proliferation. (1993) (7)
Lack of relationship of AT1001 to zonulin and prehaptoglobin-2: clinical implications (2020) (7)
Functional polymorphism of the HLA-DR beta III chain. (1988) (7)
The Influence of the Workshop Monoclonal Antibodies on CML, AgTR, PLT, ADCC, and NK Cell Activity. Functional Studies with Workshop Antibodies (1986) (7)
Gamma delta T cell reactivity towards bacterial superantigens. (1993) (7)
Celiac disease: sandwiched between innate and adaptive immune responses induced by gluten. (2008) (7)
Divergent and invariant HLA class II beta chain isoelectric points. (1986) (6)
IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement (2018) (6)
A novel T-cell-defined HLA-DR polymorphism not predicted from the linear amino acid sequence. (1989) (6)
Mannosylated self‐peptide inhibits the development of experimental autoimmune encephalomyelitis via expansion of nonencephalitogenic T cells (2008) (6)
γδ T cells in coeliac disease (1990) (6)
Reactivity of human gamma delta T cells to staphylococcal enterotoxins: a restricted reaction pattern mediated by two distinct recognition pathways. (1993) (6)
Ultrastructural localization of HLA-DR and HLA-DQ molecules in Langerhans cells and B cells: an immunoelectronmicroscopic study. (1988) (6)
Strategies for Prevention of Celiac Disease (2008) (6)
Typing for HLA class II at the product level. (1985) (6)
T-cell receptor usage of interleukin-2-responsive peripheral gamma delta T cells. (1995) (6)
Selective removal of clonogenic neoplastic B cells from human bone marrow using anti-HLA-DQ antibodies and complement. (1986) (6)
The million-dollar question: is "gluten-free" food safe for patients with celiac disease? (2013) (5)
Gamma delta T cells in coeliac disease. (1990) (5)
Ranking of immunodominant epitopes in celiac disease: Identification of reliable parameters for the safety assessment of innovative food proteins. (2021) (5)
Memory CD8+ T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment (2020) (5)
Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques (2013) (5)
A biased view toward celiac disease (2016) (5)
Analysis of early fetal T-cell receptor δ chain in humans (2004) (5)
The impact of single amino acid substitutions in CD3gamma on the CD3epsilongamma interaction and T-cell receptor-CD3 complex formation. (2006) (5)
Identification of Two Distinct Function γδ TCR Complexes on the Surface of a Human T Cell Clone (1995) (4)
Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells (2021) (4)
The majority of HLA-DR3 alloreactive T cells is peptide specific, but does not recognize known DR3-bound sequences. (1998) (4)
Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease (2020) (4)
Natural peptides isolated from Gly 86 /Val 86 -containing variants of HLA-DR1,-DR (1996) (4)
Heterogeneity of HLA Class II Gene Products as Studied in a Family by Sequential Immunoprecipitation (1984) (4)
Predicting cell types in single cell mass cytometry data (2018) (4)
Interactive Visual Analysis of Mass Cytometry Data by Hierarchical Stochastic Neighbor Embedding Reveals Rare Cell Types (2017) (4)
γδ T cells are effectors of immune checkpoint blockade in mismatch repair-deficient colon cancers with antigen presentation defects (2021) (4)
Identification of a new lymphocyte subset surface antigen, the expression of which disappears after in vitro and in vivo stimulation. Distribution, biochemistry, and functional studies. (1986) (4)
Coordinated V gamma and V delta gene segment rearrangements in human T cell receptor gamma/delta+ lymphocytes. (1989) (4)
prolyl endoprotease: implications for celiac disease (2006) (3)
Isolation and Cloning of Gluten-Specific T Cells in Celiac Disease. (2015) (3)
Ligands HLA-DM Expression on the Nature of Strong Influence of Invariant Chain and Repertoire in Endocrine Epithelial Cells : Dissection of the HLA-DR 4 Peptide (2004) (3)
Statement of the Prolamin Working Group on the Determination of Gluten in Fermented Foods Containing Partially Hydrolyzed Gluten (2021) (3)
Synthetic Peptide libraries for T-cell epitope identification. (2000) (3)
Abstracts from the Food Allergy and Anaphylaxis Meeting 2016 (2017) (3)
Celiac disease: New therapies on the horizon. (2022) (3)
Anticytomegalovirus seropositivity in rheumatoid arthritis is not associated with the presence of severe extraarticular complications: comment on the article by Pierer et al. (2012) (3)
implications for coeliac disease endoprotease in a gastrointestinal model: Efficient degradation of gluten by a prolyl (2008) (3)
γδ T cells in coeliac disease. Discussion (1990) (3)
Phenotypical heterogeneity among human T cell receptor gamma/delta-expressing clones derived from peripheral blood. (1989) (3)
Identification of a Disease-Associated Network of Intestinal Immune Cells in Treatment-Naive Inflammatory Bowel Disease (2022) (3)
P363 Locally injected allogeneic bone marrow-derived mesenchymal stromal cells for the treatment of refractory proctitis: clinical results of a phase IIa trial (2021) (2)
Single-Cell Analysis of Refractory Celiac Disease Demonstrates Inter- and Intra-Patient Aberrant Cell Heterogeneity (2022) (2)
Celiac disease and malignancy: an immunological basis? (1997) (2)
Human γδ T‐Cells in the Epithelium of the Gut and in the Inflamed Synovial Tissue Preferentially Express the Vγ8 T‐Cell Receptor Chain (1995) (2)
Structural comparison of alpha/beta and gamma/delta T cell receptor-CD3 complexes reveals identical subunit interactions but distinct cross-linking patterns of T cell receptor chains. (1990) (2)
Visual analysis of mass cytometry data by hierarchical stochastic neighbour embedding reveals rare cell types (2017) (2)
Memory CD4+ T cells are generated in the human fetal intestine (2019) (2)
The power and potential of BIOMAP to elucidate host‐microbiome interplay in skin inflammatory diseases (2021) (2)
T cell receptor gamma/delta chain diversity (1988) (2)
Presence of gluten proteins in breast milk: implications for the development of celiac disease (2008) (1)
Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and gatekeeper features (2022) (1)
Mass Cytometric Analysis of Early-Stage Mycosis Fungoides (2022) (1)
Function of DRw52 and LB-Q1 in Antigen Presentation (1984) (1)
DOP64 Endoscopically injected allogeneic mesenchymal stromal cells alter the mucosal immune cell compartment in patients with ulcerative proctitis (2021) (1)
Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry (2022) (1)
Gluten toxicity, how to get rid of it? (2011) (1)
Properties of HLA-DQ2 Ligands Explains the Unique Gluten-Binding Large-Scale Characterization of Natural (2013) (1)
Sa1772 Ilc-Like Lymphomas in Refractory Celiac Disease Type II Respond to Multiple Common γ-Chain Cytokines and Are Sensitive to JAK-Inhibitors (2015) (1)
Transdimer β / DQ 8 α HLA-DQ 8 and the HLA-DQ 2 Gluten-Specific T Cells Cross-React between Papadopoulos (2011) (1)
Coeliac Disease and Gluten-Related Disorders (2015) (1)
B-cell epitopes of α-gliadin in celiac children and in controls (1997) (1)
Selection in Celiac Disease Determinants of Gliadin-Specific T Cell (2015) (1)
PS13 - 66. The type 1 diabetes associated HLA-DQ8-transdimer accommodates a unique islet peptide repertoire (2011) (1)
Analysis of early fetal T-cell receptor delta chain in humans. (1990) (1)
Immunoelectron Microscopic Analysis of Major Histocompatibility Class II Expression on Human Epidermal Langerhans Cells (1995) (1)
Analysis of the donor-specific cytotoxic T-cell repertoire in a patient with a long-term surviving kidney allograft. (1990) (1)
Performance characteristics of a new competitive DQ2.5-glia-α3 gliadin ELISA (2020) (1)
Cytosplore: Interactive Visual Single-Cell Profiling of the Immune System (2019) (1)
LB-Q1 and LB-Q2: Population Genetics in Dutch Caucasoids and Inhibition Studies with Monoclonal Antibodies (1984) (0)
Celiac disease and malignancy : An immunological basis? Discussion (1997) (0)
NK cells in stem cell transplantation as tumour therapy: dissecting the role of KIR in an in vivo mouse model (2005) (0)
28-OR Control of HIV-1 replication: Human long-term non-progressors and chimpanzees share MHC class I molecules with similar functional properties (2011) (0)
SP0209 Lessons from Coeliac Disease (2015) (0)
Nature of Ligands Invariant Chain and HLA-DM Expression on the Endocrine Epithelial Cells: Strong Influence of Dissection of the HLA-DR4 Peptide Repertoire in (2011) (0)
Coeliac disease: on the way to immunotherapy! (2001) (0)
114 A Th-1 LIKE CYTOKINE PRODUCTION PATTERN OF CD8− TcRa T-CELLS FROM THE SMALL INTESTINE OF COELIAC PATIENTS (1995) (0)
New developments for the allergenicity assessment of GM plants (2017) (0)
Receptors of CD4 T Cells Expressing Killer Ig-Like Phenotypic and Functional Characterization (2004) (0)
Visualizing the players of the maternal immune response at the maternal-fetal interface by high-dimensional mass cytometry (2017) (0)
PS19 - 88. Mast cell deficient mice on a high fat diet have altered immune cell infiltration in their adipose tissue (2012) (0)
Langerhans cells and EBV-transformed B cells differ with respect to the distribution of endosomal/lysosomal markers in the MHC class II compartment. (1996) (0)
TCR gamma delta cells: antigen-driven expansion of distinct subsets based on localization and antigen specificity. (1991) (0)
Brief Derinitive Report PRODUCTION OF A T CELL HYBRIDOMA THAT EXPRESSES THE T CELL RECEPTOR 7/b HETERODIMER BY (2003) (0)
Local administration of mesenchymal stromal cells is safe and modulates the immune compartment in ulcerative proctitis. (2023) (0)
Synaptojanin 2B is recognized by an HLA class II restricted Hairy Cell Leukemia specific T cell clone. (2001) (0)
Letter: gluten digestion in the stomach and duodenum by Aspergillus niger‐derived enzyme – things to ponder. Authors’ reply (2015) (0)
====CHAPTERS==== IMMUNOELECTRON MICROSCOPIC ANALYSIS OF MAJOR HISTOCOMPATIBILITY Cuss II ExPREsSION ON HUMAN EPIDERMAL (1995) (0)
The HLA A03 Supertype and Several Pan Species Major Histocompatibility Complex Class I A Allotypes Share a Preference for Binding Positively Charged Residues in the F Pocket: Implications for Controlling Retroviral Infections (2020) (0)
High-Dimensional Mass Cytometric Analysis of the Bone Marrow Compartment Identifies a Disease-Specific Immune Cell Network in Aplastic Anemia (2022) (0)
4 B CELL EPITOPES IN COELIAC DISEASE (1995) (0)
Prevention against illness by means of a mouse model for MS (2002) (0)
Epithelial cells expressing class II molecules: can they present naturally processed peptides? (1997) (0)
Chapter Fine specificity of monoclonal antibodies against celiac disease-inducing peptides present in the gluteome (2011) (0)
Best Abstracts (2004) (0)
Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation (2023) (0)
54-OR: KIR-ligand mismatches are associated with reduced long-term graft survival in HLA fully compatible kidney transplantation (2011) (0)
OP27 High-dimensional mass cytometry reveals the immune cell landscape in inflammatory bowel disease (2019) (0)
Abstract A063: Multidimensional cytometric analysis of colorectal cancer reveals novel and diverse mediators of antitumor immunity (2019) (0)
High-dimensional mass cytometry analysis of immune cells in emphysematous lung tissue (2020) (0)
Celiac Disease: Can a Th1-Mediated Disease Teach Us How to Study the Non-Ige-Mediated Food Allergies? (2018) (0)
Bacterial immune modulation of the cytokine response elicited by gliadin in an in vitro model ofceliac disease (2013) (0)
Characterization of Intestinal τδ and αβ T-cell Receptor Positive Cells in Coeliac Disease (1991) (0)
Cytomegalovirus T Cells Specific for + Human Memory CD4 Functional Killer Ig-Like Receptors on (2009) (0)
Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules (2012) (0)
Immunotherapy of celiac disease: fact or fallacy? (2002) (0)
Receptors of CD 4 T Cells Expressing Killer Ig-Like Phenotypic and Functional Characterization (2004) (0)
Characterization of HLA-DQ-Specific Peptide-Binding Motifs. (2000) (0)
Immune response to 100 mg gluten introduced at 4 months of age: results from the PreventCD cohort. (2011) (0)
A Tertiary Twist to the Transglutaminase Tale (2007) (0)
Biomarker identification to assess effects of bone-marrow derived mesenchymal stromal cell-therapy in emphysema through immune profiling (2022) (0)
PO-260 Deep phenotyping of colorectal cancers by high-dimensional mass cytometry reveals tumor-specific immune landscapes (2018) (0)
CHARACTERIZATION OF INTESTINAL γδ T-CELLS IN COELIAC DISEASE (1991) (0)
Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques (2013) (0)
Diversity of γs̀ T‐cell Receptors Expressed by Dendritic Epidermal Cell Lines (1988) (0)
Cell Surface Molecules, Immunoprecipitation of (1998) (0)
Receptorsof CD4 T Cells Expressing Killer Ig-Like Phenotypic and Functional Characterization (2004) (0)
Three Functionally Distinct DRw52 Subtypes Are Alleles of the DRβIII Locus (1989) (0)
GAMMA DELTA T CELLS IN COELIAC DISEASE. DISCUSSION (1990) (0)
Editorial: enhancing gluten digestion in the stomach – a further help to minimise unintentional ingestion? Authors’ reply (2015) (0)
Properties of HLA-DQ 2 Ligands Explains the Unique Gluten-Binding Large-Scale Characterization of Natural Papadopoulos (2008) (0)
TCR γ Chain Expression on Human Peripheral Blood T Lymphocytes (1989) (0)
Mass Cytometry Marker Panel Extension (2017) (0)
P079 High-dimensional mass cytometry after local MSC treatment in patients with refractory proctitis shows an effect on the myeloid compartment: preliminary data (2020) (0)
Mediate ''Missing Self'' Recognition In Vivo Cutting Edge: Killer Ig-Like Receptors (2009) (0)
Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation (2012) (0)
Coeliac Disease in Subfertile Couples in the Netherlands (2011) (0)
MHC CLASS I MOLECULE WITH NON-CLASSICAL FEATURES HAS HLA-B*27-LIKE PEPTIDE-BINDING CHARACTERISTICS (2015) (0)
Persistent Increase of Intra-Epithelial T-Cell Receptor τ δ Cells in Coeliac Disease (1991) (0)
PROBIOTICS INHIBIT THE DEVELOPMENT OF INFLAMMATORY PROCESSES IN RECURRENT TNBS-COLITIS : INSIGHTS FROM INTESTINAL TRANSCRIPTOME ANALYSIS (2011) (0)
PS13 - 3. Fcγ- and ε-receptors do not play a role in the initial development of insulin resistance (2013) (0)
Recognition of HLA-DQ gluten is mediated by a relatively conserved set of T-cell receptors that predominate in patients and appear absent in healthy individuals (2015) (0)
Increased amount of regulatory T cells may be required in attaining an ongoing uncomplicated pregnancy after unexplained recurrent pregnancy loss. (2021) (0)
Celiac disease: a functional genomics approach to define molecular pathways (2002) (0)
Towards peptide based therapeutics-Applications in celiac disease and infectious diseases (2006) (0)
Functional human epidermal Langerhans cells that lack birbeck granules (1993) (0)
L3-12 complex (2015) (0)
Strong Influence of Invariant Chain and Repertoire in Endocrine Epithelial Cells: Dissection of the HLA-DR4 Peptide (2013) (0)
Visual Analysis of Tissue Images at Cellular Level (2021) (0)
Chapter 5 Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for celiac disease (2011) (0)
PS15 - 75. Differences in adipocyte morphology and immune cell population in adipose tissues from metabolically healthy and unhealthy severely obese women (2011) (0)
Celiac disease: quantity matters (2012) (0)
Correction: A Universal Approach to Eliminate Antigenic Properties of Alpha-Gliadin Peptides in Celiac Disease (2012) (0)
Y-Chain T Cell Receptors on Denoritic Epidermal Cells (1988) (0)
84 PEPTIDE-BINDING PROPERTIES OF THE COELIAC DISEASE-ASSOCIATED HLA-DQ(α1*0501, β1*0201) MOLECULE (1996) (0)
Humanized Mouse Model Expression Level and Frequency in a HLA Reduces Killer Cell Ig-like Receptor (2013) (0)
353 Localization and Phenotype of the Gliadin-Specific T-Cell Response After Oral Gliadin Intake in Mice (2009) (0)
Isolation of gluten-specific, HLA-DQ-restricted T cells from the small intestinal mucosa of a coeliac disease patient (1997) (0)
43-OR: Evidence for Natural Killer Cell Induced Graft Loss in HLA Full Compatible Kidney Transplantation (2010) (0)
THE MACAQUE A2*05 GENE ENCODES FOR SPECIALIST MHC MOLECULES WITH HLA-B*27-LIKE PEPTIDE-BINDING CHARACTERISTICS (2017) (0)
Su2096 Gluten Degrading Enzyme Effectively Digests Gluten in the Stomach and Small Intestine of Healthy Volunteers (2014) (0)

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