Fung‐lung Chung
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Chemistry Biology
Fung‐lung Chung's Degrees
- PhD Biochemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
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(Suggest an Edit or Addition)Fung‐lung Chung's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Novel Mechanism of Chemoprotection by Sulforaphane (2004) (518)
- Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China (2000) (456)
- Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants. (1992) (398)
- Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. (2002) (385)
- Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. (2000) (362)
- Lipid peroxidation as a potential endogenous source for the formation of exocyclic DNA adducts. (1996) (343)
- Disposition of Glucosinolates and Sulforaphane in Humans After Ingestion of Steamed and Fresh Broccoli (2000) (319)
- Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde. (1984) (293)
- Tea and cancer prevention: studies in animals and humans. (2003) (270)
- Urinary isothiocyanate levels, brassica, and human breast cancer. (2003) (251)
- Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress. (1999) (246)
- The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. (2002) (246)
- Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. (2005) (233)
- Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. (2002) (217)
- Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate. (1989) (213)
- Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. (1989) (202)
- Covalent Binding to Tubulin by Isothiocyanates (2006) (198)
- Detection of exocyclic 1,N2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans. (1994) (190)
- Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypes. (1998) (181)
- Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols. (2002) (180)
- Quantitation of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress meal. (1992) (173)
- Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. (1995) (170)
- Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice. (1990) (160)
- Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: detection and potential sources. (2000) (159)
- Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet. (1989) (158)
- Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. (1991) (149)
- Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 activity and induction of apoptosis. (2002) (148)
- The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells. (2007) (146)
- Induction of liver tumors in F344 rats by crotonaldehyde. (1986) (137)
- Endogenous formation and significance of 1,N2-propanodeoxyguanosine adducts. (1999) (129)
- 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. (1988) (121)
- Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates. (1990) (121)
- 1,N2-propanodeoxyguanosine adducts: potential new biomarkers of smoking-induced DNA damage in human oral tissue. (1998) (120)
- Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice. (1993) (120)
- Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27* (2010) (119)
- Inhibition of rat liver cytochrome P450 isozymes by isothiocyanates and their conjugates: a structure-activity relationship study. (1996) (118)
- Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. (2004) (118)
- Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates. (1989) (118)
- Detection of 1, N2-propanodeoxyguanosine adducts as potential endogenous DNA lesions in rodent and human tissues. (1996) (116)
- Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats. (1996) (109)
- Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. (2001) (108)
- Synthesis of (-)-[4-3H]epigallocatechin gallate and its metabolic fate in rats after intravenous administration. (2001) (106)
- Cancer Preventive Isothiocyanates Induce Selective Degradation of Cellular α- and β-Tubulins by Proteasomes* (2009) (105)
- Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent. (1998) (100)
- Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone alpha-hydroxylation and DNA methylation in rat liver. (1985) (98)
- Proteins as binding targets of isothiocyanates in cancer prevention. (2011) (98)
- Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest. (2004) (98)
- Structure-activity relationships of isothiocyanates as mechanism-based inhibitors of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. (1994) (98)
- Molecular and cellular effects of green tea on oral cells of smokers: a pilot study. (2005) (96)
- Reproducibility of Plasma, Red Blood Cell, and Urine Biomarkers among Premenopausal and Postmenopausal Women from the Nurses' Health Studies (2010) (95)
- Characterization of a glucuronide metabolite of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its dose-dependent excretion in the urine of mice and rats. (1990) (95)
- High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate. (2001) (90)
- Stereoselective formation of in vitro nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal. (1991) (89)
- A urinary biomarker for uptake of dietary isothiocyanates in humans. (1998) (85)
- Distribution and metabolism of the natural anticarcinogen phenethyl isothiocyanate in A/J mice. (1990) (85)
- Identification and quantification of the N-acetylcysteine conjugate of allyl isothiocyanate in human urine after ingestion of mustard. (1994) (84)
- Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships. (2011) (84)
- Increased 8-oxodeoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with the tobacco-specific nitrosamine 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone. (1992) (84)
- Formation of cyclic 1,N2--adducts by reaction of deoxyguanosine with alpha-acetoxy-N-nitrosopyrrolidine, 4-(carbethoxynitrosamino)butanal, or crotonaldehyde. (1983) (81)
- Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis. (1991) (77)
- Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility* (2012) (74)
- Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth (2016) (74)
- Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats. (1999) (74)
- SHORT COMMUNICATION: Chemopreventive effects of phenethy1 isothiocyanate on lung and pancreatic tumorigenesis inN-nitrosobis(2-oxopropyl)amine-treated hamsters (1996) (73)
- Formation of cyclic deoxyguanosine adducts from ω-3 and ω-6 polyunsaturated fatty acids under oxidative conditions (2002) (71)
- Isothiocyanates, glutathione S‐transferase M1 and T1 polymorphisms and gastric cancer risk: A prospective study of men in Shanghai, China (2009) (70)
- Total Isothiocyanate Contents in Cooked Vegetables Frequently Consumed in Singapore (1998) (70)
- Identification of potential protein targets of isothiocyanates by proteomics. (2011) (68)
- Carcinogen biomarkers related to smoking and upper aerodigestive tract cancer (1993) (68)
- Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from ω-3 and ω-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation (2003) (67)
- Effects of dietary compounds on alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine in rat target tissues. (1984) (66)
- Epoxidation of trans-4-hydroxy-2-nonenal by fatty acid hydroperoxides and hydrogen peroxide. (1996) (65)
- 2,3-epoxy-4-hydroxynonanal as a potential tumor-initiating agent of lipid peroxidation. (1993) (62)
- Inhibition of the Tobacco‐Specific Nitrosamine‐Induced Lung Tumorigenesis by Compounds Derived from Cruciferous Vegetables and Green Tea a (1993) (62)
- Chemopreventive activity of thiol conjugates of isothiocyanates for lung tumorigenesis. (1997) (62)
- The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea. (1999) (61)
- Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells. (2011) (61)
- Role of 1,N2-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans. (1999) (61)
- Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin. (2011) (59)
- Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates. (1996) (58)
- Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk. (2010) (58)
- Detection of cyclic 1,N2-propanodeoxyguanosine adducts in DNA of rats treated with N-nitrosopyrrolidine and mice treated with crotonaldehyde. (1989) (56)
- Modulation of growth of human prostate cancer cells by the N-acetylcysteine conjugate of phenethyl isothiocyanate. (2000) (56)
- Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice. (1990) (55)
- Structural characterization of adducts formed in the reaction of 2,3-epoxy-4-hydroxynonanal with deoxyguanosine. (1989) (54)
- Detection of acrolein and crotonaldehyde DNA adducts in cultured human cells and canine peripheral blood lymphocytes by 32P-postlabeling and nucleotide chromatography. (1991) (54)
- Oral cytology assessment by flow cytometry of DNA adducts, aneuploidy, proliferation and apoptosis shows differences between smokers and non-smokers. (2003) (53)
- Cigarette smoking and adenocarcinoma of the lung: The relevance of nicotine-derived N-nitrosamines (1993) (52)
- Detection and quantification of 1,N(6)-ethenoadenine in human placental DNA by mass spectrometry. (1999) (51)
- Repair kinetics of acrolein- and (E)-4-hydroxy-2-nonenal-derived DNA adducts in human colon cell extracts. (2013) (51)
- Formation of etheno adducts in reactions of enals via autoxidation. (1994) (51)
- Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts. (2004) (48)
- Application of an immunoassay for cyclic acrolein deoxyguanosine adducts to assess their formation in DNA of Salmonella typhimurium under conditions of mutation induction by acrolein. (1989) (47)
- New potential chemopreventive agents for lung carcinogenesis of tobacco-specific nitrosamine. (1992) (47)
- Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates. (2010) (47)
- Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in N-nitrosobis(2-oxopropyl)amine-treated hamsters. (1996) (46)
- Effects of dietary sinigrin or indole-3-carbinol on O6-methylguanine-DNA-transmethylase activity and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA methylation and tumorigenicity in F344 rats. (1988) (45)
- Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China. (2003) (44)
- Urinary Isothiocyanates; Glutathione S-Transferase M1, T1, and P1 Polymorphisms; and Risk of Colorectal Cancer: The Multiethnic Cohort Study (2009) (44)
- Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A. (2001) (43)
- Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice. (2011) (43)
- Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid. (2009) (43)
- Formation of cyclic deoxyguanosine adducts in Chinese hamster ovary cells by acrolein and crotonaldehyde. (1990) (43)
- Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response. (2010) (42)
- Oxidative stress and hepatocarcinogenesis (2018) (40)
- Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis. (2013) (38)
- Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery. (2009) (36)
- Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenoma formation in A/J mice. (1992) (36)
- Dietary Control of Cancer (1997) (36)
- Identification of crotonaldehyde as a hepatic microsomal metabolite formed by alpha-hydroxylation of the carcinogen N-nitrosopyrrolidine. (1988) (35)
- Carcinogenicity of acrolein, crotonaldehyde, and arecoline. (2020) (35)
- Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation. (2003) (35)
- Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats. (2003) (34)
- Inhibition by phenylethyl and phenylhexyl isothiocyanate of metabolism of and DNA methylation by N-nitrosomethylamylamine in rats. (1993) (34)
- Chemopreventive potential of thiol conjugates of isothiocyanates for lung cancer and a urinary biomarker of dietary isothiocyanates (1997) (33)
- Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl) retinamide and beta-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice. (1998) (33)
- Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver. (2005) (33)
- Urinary Total Isothiocyanates and Colorectal Cancer: A Prospective Study of Men in Shanghai, China (2008) (33)
- Binding to Protein by Isothiocyanates: A Potential Mechanism for Apoptosis Induction in Human Nonsmall Lung Cancer Cells (2008) (32)
- A Study of Reactions of α,β-Unsaturated Carbonyl Compounds with Deoxyguanosine (1988) (32)
- Simultaneous determination of sulforaphane and its major metabolites from biological matrices with liquid chromatography-tandem mass spectroscopy. (2006) (31)
- Inhibitory effects of 2-mercaptoethane sulfonate and 6-phenylhexyl isothiocyanate on urinary bladder tumorigenesis in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. (2003) (30)
- Effects of butylated hydroxyanisole on the tumorigenicity and metabolism of N-nitrosodimethylamine and N-nitrosopyrrolidine in A/J mice. (1986) (29)
- Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. (2002) (29)
- Aldo‐keto reductase 1B10 protects human colon cells from DNA damage induced by electrophilic carbonyl compounds (2017) (28)
- Proteomic analysis of covalent modifications of tubulins by isothiocyanates. (2012) (28)
- Detoxification: A Novel Function of BRCA1 in Tumor Suppression? (2011) (28)
- Effects of nonsteroidal antiinflammatory drugs on oxidative pathways in A/J mice. (1995) (28)
- N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells. (2005) (27)
- Endogenous production of DNA adducts. (1996) (27)
- CHEMOPREVENTION OF LUNG CANCER BY ISOTHIOCYANATES AND THEIR CONJUGATES IN A/J MOUSE (2001) (27)
- Detection of acrolein-derived cyclic DNA adducts in human cells by monoclonal antibodies. (2012) (25)
- Urinary isothiocyanate levels and lung cancer risk among non-smoking women: a prospective investigation. (2011) (25)
- Detection of exocyclic guanine adducts in hydrolysates of hepatic DNA of rats treated with N-nitrosopyrrolidine and in calf thymus DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine. (1989) (25)
- DNA adducts of 2,3-epoxy-4-hydroxynonanal: detection of 7-(1', 2'-dihydroxyheptyl)-3H-imidazo[2,1-i]purine and 1,N6-ethenoadenine by gas chromatography/negative ion chemical ionization/mass spectrometry. (1998) (25)
- Detection of the acrolein-derived cyclic DNA adduct by a quantitative 32P-postlabeling/solid-phase extraction/HPLC method: blocking its artifact formation with glutathione. (2008) (24)
- 2,3-epoxy-4-hydroxynonanal, a potential lipid peroxidation product for etheno adduct formation, is not a substrate of human epoxide hydrolase. (1998) (24)
- Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity (2017) (23)
- A 32P-postlabeling method for simultaneous detection and quantification of exocyclic etheno and propano adducts in DNA. (1994) (23)
- Reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts. (1995) (23)
- A solid-phase extraction/high-performance liquid chromatography-based (32)P-postlabeling method for detection of cyclic 1,N(2)-propanodeoxyguanosine adducts derived from enals. (2006) (23)
- Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J mice and F344 rats. (1989) (22)
- Reaction of alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: oxygen-dependent formation of 4-oxo-2-pentenal and a 1,N2-ethenodeoxyguanosine adduct. (1992) (21)
- 1,N(2)-propanodeoxyguanosine adduct formation in aortic DNA following inhalation of acrolein. (2001) (21)
- p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition (2019) (21)
- Differential effects of thiols on DNA modifications via alkylation and Michael addition by alpha-acetoxy-N-nitrosopyrrolidine. (1992) (21)
- Effect of glutathione depletion on exocyclic adduct levels in the liver DNA of F344 rats. (1997) (20)
- A/J mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates. (1991) (19)
- Metabolism of isothiocyanates in individuals with positive and null GSTT1 and M1 genotypes after drinking watercress juice. (2010) (19)
- Formation of the cyclic 1,N2-glyoxal-deoxyguanosine adduct upon reaction of N-nitroso-2-hydroxymorpholine with deoxyguanosine. (1985) (18)
- The essential role of the functional group in alkyl isothiocyanates for inhibition of tobacco nitrosamine-induced lung tumorigenesis. (1996) (18)
- Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates. (1991) (18)
- Regioselective formation of acrolein-derived cyclic 1,N(2)-propanodeoxyguanosine adducts mediated by amino acids, proteins, and cell lysates. (2012) (17)
- Synthesis of certain [6:5:6] linear tricyclic nucleosides as potential antitumor agents. (1980) (17)
- Carcinogenicity and metabolic activation of tobacco-specific nitrosamines: current status and future prospects. (1984) (16)
- In vivo detection of a novel endogenous etheno-DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation. (2014) (15)
- Proteomic identification of binding targets of isothiocyanates: A perspective on techniques. (2011) (15)
- Potential Inhibitors of Tobacco Carcinogenesis a (1993) (15)
- Photoaddition of chlorpromazine to DNA. (1984) (14)
- Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity. (2017) (14)
- Formation of the acrolein-derived 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with 3-(N-carbethoxy-N-nitrosamino)propionaldehyde. (1994) (13)
- Formation of acyclic and cyclic guanine adducts in DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine. (1989) (13)
- Development of a monoclonal antibody-based immunoassay for cyclic DNA adducts resulting from exposure to crotonaldehyde. (1987) (13)
- Formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts in the reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with DNA. (1995) (13)
- Development of monoclonal antibodies specific for 1,N2-ethenodeoxyguanosine and N2,3-ethenodeoxyguanosine and their use for quantitation of adducts in G12 cells exposed to chloroacetaldehyde. (1993) (13)
- An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice (2018) (12)
- Protection Against Tobacco-Specific, Nitrosamine-Induced Lnng Tumorigenesis by Green Tea and Its Components (1992) (12)
- Acute toxicity oftrans-5-hydroxy-2-nonenal in fisher 344 rats (2006) (11)
- Effects of Epigallocatechin Gallate, L-Ascorbic Acid, α-Tocopherol, and Dihydrolipoic Acid on the Formation of Deoxyguanosine Adducts Derived From Lipid Peroxidation (2010) (11)
- Chemopreventive Effects of 3‐Phenylpropyl Isothiocyanate on Hamster Lung Tumorigenesis Initiated with N‐Nitrosobis(2‐oxopropyl)amine (1996) (11)
- Deoxyguanosine adducts of tert-4-hydroxy-2-nonenal as markers of endogenous DNA lesions. (2002) (11)
- Acute toxicity oftrans-5-hydroxy-2-nonenal in fisher 344 rats (2006) (11)
- Investigations on the molecular dosimetry of tobacco-specific N-nitrosamines. (1987) (11)
- In vitro but not in vivo inhibition of CYP2D6 by phenethyl isothiocyanate (PEITC), a constituent of watercress. (1994) (11)
- Green tea and leukoplakia (1997) (10)
- Detection of a lipid peroxidation-induced DNA adduct across liver disease stages. (2018) (10)
- Prevention of Lipid Peroxidation–derived Cyclic DNA Adduct and Mutation in High-Fat Diet–induced Hepatocarcinogenesis by Theaphenon E (2018) (9)
- REDUCTIVE DEBROMINATION OF SOME PURINE AND PURINE-LIKE NUCLEOSIDES (1980) (8)
- General route for the facile synthesis of pyrimidin-2-one-4-thione derivatives via the annulation of cyclic o-aminonitriles using carbonyl sulfide (1981) (8)
- Theaphenon E prevents fatty liver disease and increases CD4+ T cell survival in mice fed a high-fat diet. (2020) (8)
- Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships. (2021) (8)
- A six-month crossover chemoprevention clinical trial of tea in smokers and non-smokers: methodological issues in a feasibility study (2012) (7)
- Formation of cyclic nucleic acid adducts from some simple alpha, beta-unsaturated carbonyl compounds and cyclic nitrosamines. (1986) (7)
- Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein. (2016) (7)
- High-throughput, Quantitative Analysis of Acrolein-derived DNA Adducts in Human Oral Cells by Immunohistochemistry (2012) (6)
- Formation of 7-(4-oxobutyl)guanine in hepatic DNA of rats treated with N-nitrosopyrrolidine. (1992) (6)
- Synthesis of 5-amino-9-(.beta.-D-ribofuranosyl)-v-triazino-[4,5-b]pyrimido[4,5-d]pyrrol-4-one and unusual ring opening of this new ring system with the Vilsmeier-Haack reagent (1980) (6)
- Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate. (1990) (5)
- A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate. (2014) (5)
- Phytochemicals in the Prevention of Lung Cancer Induced by Tobacco Carcinogens (2006) (5)
- Inhibition of Histone Deacetylase A Novel Mechanism of Chemoprotection by Sulforaphane : Updated (2004) (5)
- 3-(2-Deoxy-.beta.-D-erythropentofuranosyl)-6,7-dihydro-6,7-dihydroxyimidazo[1,2-a]purin-9(3H)-one, a major deoxyguanosine adduct formed from a novel diazo hydroxide product of .alpha.-hydroxylation of the carcinogen N-nitrosomorpholine. (1986) (5)
- The novel synthesis of a [6:5:6] linear isoguanosine type tricyclic nucleoside using carbonyl sulfide (1980) (5)
- 32P-postlabelling with high-performance liquid chromatography for analysis of abundant DNA adducts in human tissues. (1999) (5)
- Tea as Antioxidant in Prevention of Lung Cancer (1997) (5)
- Effects of garage employment and tobacco smoking on breathing-zone concentrations of carbonyl compounds. (2003) (5)
- Acute toxicity of trans-4-hydroxy-2-nonenal in Fisher 344 rats [corrected]. (1992) (4)
- Dietary Isothiocyanates: Roles in Cancer Prevention and Metabolism in Rodents and Humans (2002) (3)
- Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids. (2018) (3)
- Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl) retinamide and β-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice1This is paper 27 in the series `Dietary Inhibitors of Chemical Carcinogenesis'.1 (1998) (3)
- Thirty day multiple dose administration of PEITC A phase I study with steady state pharmacokinetics showing good tolerance through 120 mg daily (2001) (2)
- A Study of Chemical Carcinogenesis. Part 104. A Study of Reactions of α,β-Unsaturated Carbonyl Compounds with Deoxyguanosine. (1988) (2)
- Structure-Activity Relationships for Inhibition of 4-(Methylnitrosamino)-l-(3- pyridyl)-l-butanone Lung Tumorigenesis by Arylalkyl Isothiocyanates in A/J Mice1 (2006) (2)
- Proceedings of the Third International Scientific Symposium on Tea and Human Health : Role of Flavonoids in the Diet Tea and Cancer Prevention : Studies in Animals and Humans 1 (2003) (2)
- Inhibition of target tissue activation of N'-nitrosonornicotine and N-nitrosopyrrolidine by dietary components. (1984) (1)
- Detection of exocyclic 1 , N 2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans ( acrolein / crotonaldehyde ) (1)
- Abstract 1261: Lipid-peroxidation derived DNA damage is prevented in obesity-related hepatocarcinogenesis through CD4+ mediated apoptosis in the livers of mice on a green-tea diet (2017) (1)
- Abstract 4314: Using antioxidant to enhance liver cancer preventive effect of n-3 PUFAs (2016) (1)
- Reactions of N-nitrosomorpholine metabolites with deoxyguanosine and DNA (1985) (1)
- p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition (2019) (1)
- Relevance of Nicotine-Derived N-Nitrosamines in Tobacco Carcino-Genesis (1991) (1)
- 3-(2-Deoxy-β-D-erythropentofuranosyl)-6,7-dihydro-6,7-dihydroxyimidazo(1,2# -a)purin-9(3H)-one, a Major Deoxyguanosine Adduct Formed from a Novel Diazo Hydroxide Product of α-Hydroxylation of the Carcinogen N-Nitrosomorpholine. (1987) (1)
- Formation of nucleic acid adducts by 2,3-epoxy-4-hydroxynonanal (1990) (0)
- Formation of Cyclic 1 , / V 2-Propanodeoxyguanosine Adducts in DMA upon Reaction with Acrolein or Crotonaldehyde 1 2 (2006) (0)
- Sequential Demonstration of Lipid Peroxidation-related Biomolecules in Rat Livers Treated with Carbon Tetrachloride (1998) (0)
- Abstract 2733: Development of novel monoclonal antibodies for a cyclic DNA adduct derived from oxidation of ω-6 polyunsaturated fatty acids (2015) (0)
- Toxicology Nicotine-Derived N-Nitrosamines (TSNA) and Their Relevance In Tobacco Carci nogenesis (1991) (0)
- Abstract B42: Structure-activity study of tubulin precipitation by thiol-reactive compounds (2011) (0)
- Abstract 269: Reactivation of mutant p53 in human prostate cancer cells as a critical mechanism for inhibition of tumor growth by phenethyl isothiocyanate (2018) (0)
- Modification of deoxyguanosine via α-hydroxylation of N-nitrosopyrrolidine (1982) (0)
- Tubulin: a molecular target for COVALENT BINDING TO TUBULIN BY ISOTHIOCYANATES: A MECHANISM OF CELL GROWTH ARREST AND APOPTOSIS (2008) (0)
- Dietary Phenethyl Isothiocyanate Adduct Formation and Tumorigenicity in the Lung of F 344 Rats 4-( Methylnitrosamino )-1-( 3-pyridyl )-1-butanone-induced DNA Inhibition of Updated (2006) (0)
- Tea and Health – Interview with Yukihiko Hara, Mitsui Norin Co., Ltd. (2006) (0)
- Abstract 120: Detection of acrolein-derived cyclic DNA adducts in human cells by monoclonal antibodies. (2013) (0)
- Abstract 817: Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells (2011) (0)
- Effects of epigallocatechin gallate, vitamin C and vitamin E on the formation of 1,N2-propanodeoxyguanosine derived from lipid peroxidation (2008) (0)
- Abstract 2622: A LC-MS/MS method to quantify specific dietary isothiocyanates in human urine for epidemiological studies (2016) (0)
- Abstract 4561: Cancer preventive effect of antioxidants for spontaneous liver cancer in XPA(-/-) mice (2015) (0)
- Abstract 1629: Restoration of the wild type function to mutant p53 by chemopreventive agent phenethyl isothiocyanate (2010) (0)
- Abstract 3656: Methodology design for identifications of protein targets of chemopreventive isothiocyanates using click chemistry. (2013) (0)
- Oxidative DNA damage and apoptosis induced by docosahexaenoic acid in human colon cells (2004) (0)
- Abstract 4858: Mutant p53 depletion: a possible mechanism of inhibition of human prostate cancer by dietary phenethyl isothiocyanate. (2013) (0)
- Great Brltam THE NOVEL SYNTHESIS OF A [ 6 5 61 LINEAR ISOGUANOSINE TYPE TRICYCLIC NUCLEOSIDE USING CARBONYL SULFIDE (2001) (0)
- SYNTHESIS OF CERTAIN (6:5:6) LINEAR TRICYCLIC NUCLEOSIDES AS POTENTIAL ANTITUMOR AGENTS (1981) (0)
- Abstract A85: Mutant P53 as a potential target of chemopreventive isothiocyanates. (2011) (0)
- The Prevention of Lung Cancer Induced by a Tobacco-Specific Carcinogen in Rodents by Green and Black Tea (1999) (0)
- Advances in Brief Deoxyguanosine Adducts of t-4-Hydroxy-2-nonenal Are Endogenous DNA Lesions in Rodents and Humans : Detection and Potential Sources 1 (2000) (0)
- THE NOVEL SYNTHESIS OF A (6:5:6) LINEAR ISOGUANOSINE TYPE TRICYCLIC NUCLEOSIDE USING CARBONYL SULFIDE (1980) (0)
- Abstract 1588: Detectionin vivoof a novel endogenous etheno DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation (2014) (0)
- Abstract 6235: Detection of γ-OHPdG in circulating liver cells and its potential use as a prognostic biomarker in patients with hepatocellular carcinoma recurrence (2022) (0)
- Abstract 1694: Selective formation of the γ isomer of 1,N2-propanodeoxyguanosine adducts of acrolein through interactions with amine-containing molecules (2010) (0)
- Effects of Dietary Compounds on a-Hydroxylation of JV-Nitrosopyrrolidine and A/'-Nitrosonornicotine in Rat Target Tissues1 (2006) (0)
- Effects of butylated hydroxyanisole (BHA) on nitrosamine tumorigenesis and metabolic activation in A/J mice (1985) (0)
- Development of a Monoclonal Antibody-based Immunoassay for Cyclic DNA Adducts Resulting from Exposure to Crotonaldehyde 1 (2006) (0)
- Inhibition of tobacco carcinogen-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants (1997) (0)
- Abstract 5362: Deficiencies in mismatch repair proteins induce elevated levels of acrolein-derived 1,N2-propanodeoxyguanosine and apoptosis in human colon cancer cells treated with acrolein (2014) (0)
- Abstract 1910: Reactivation of p53R175 mutant by dietary phenethyl isothiocyanate (PEITC) impairs tumor growth in vivo (2015) (0)
- Detection in vivo of a Novel Endogenous Etheno DNA Adduct Derived from Arachidonic Acid and the Effects of Antioxidants on Its Formation (2014) (0)
- Sulforaphane Enhances Proteasome Activity through Upregulation of Hsp27 (2010) (0)
- Abstract 3691: Selective depletion of mutant p53 by isothiocyanates and its structure-activity relationships (2011) (0)
- Mechanisms of Inhibition of Tobacco-Specific Nitrosamine-Induced Lung Tumorigenesis in A/J Mice (1994) (0)
- Gr upSM Clinicopathologic Risk Factors and Biomarkers Associated with Recurrence in Patients after Curative Resection of Hepatocellular Carcinoma (2016) (0)
- Editorial: Mol. Nutr. Food Res. 2/2006 (2006) (0)
- Abstract #2980: Isothiocyanates induce formation of aggresome-like structures and inhibit ubiquitin-proteasome system (2009) (0)
- Proteins as potential targets of apoptosis induced by chemopreventive isothiocyanates. (2006) (0)
- Abstract 4051: Lipid peroxidation-derived DNA adduct formation in obesity-related hepatocarcinogenesis (2016) (0)
- Abstract 2591: Global gene expression regulated by phenethyl isothiocyanate in human colon cancer SW480 cells. (2013) (0)
- Detection of DNA adduct γ-OHPdG in circulating tumor cells (CTCs) and its use as a prognostic biomarker in patients with hepatocellular carcinoma (HCC). (2023) (0)
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