Gideon A. Rodan
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(Suggest an Edit or Addition)Gideon A. Rodan's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Bisphosphonates: mechanisms of action. (1996) (1792)
- Therapeutic approaches to bone diseases. (2000) (1633)
- Principles of Bone Biology (1996) (1505)
- Control of osteoblast function and regulation of bone mass (2003) (1400)
- Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. (1991) (1031)
- Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. (1999) (713)
- Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties. (1987) (579)
- Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. (2006) (557)
- The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. (2004) (553)
- Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma. (1980) (458)
- Different pattern of alkaline phosphatase, osteopontin, and osteocalcin expression in developing rat bone visualized by in situ hybridization (1990) (456)
- Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. (1992) (452)
- Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. (2000) (410)
- Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. (1994) (403)
- The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. (2008) (399)
- Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. (2001) (389)
- Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones. (1989) (376)
- Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. (1988) (368)
- Pathogenesis of osteoporosis. (2003) (356)
- Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. (1999) (349)
- Role of osteoblasts in hormonal control of bone resorption—A hypothesis (2006) (348)
- M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase (2003) (323)
- Tissue specificity and developmental expression of rat osteopontin. (1987) (315)
- Introduction to bone biology. (1992) (293)
- The effect of 1,25(OH)2D3 on alkaline phosphatase in osteoblastic osteosarcoma cells. (1982) (286)
- Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation. (1989) (277)
- Comparison of the distribution of 3H-alendronate and 3H-etidronate in rat and mouse bones. (1996) (265)
- PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase. (1998) (255)
- Bisphosphonates Act Directly on the Osteoclast to Induce Caspase Cleavage of Mst1 Kinase during Apoptosis (1999) (255)
- Bisphosphonate mechanism of action (2002) (250)
- Gene expression in osteoblastic cells. (1991) (236)
- DNA synthesis in cartilage cells is stimulated by oscillating electric fields. (1978) (229)
- Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): positive correlation with the presence of the GH-induced IGF-binding protein BP-3. (1990) (221)
- Integrins and signaling in osteoclast function. (2000) (209)
- High Fatty Acid Content in Rabbit Serum Is Responsible for the Differentiation of Osteoblasts Into Adipocyte‐like Cells (1998) (209)
- Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. (1983) (198)
- Cyclic AMP and cyclic GMP: mediators of the mechanical effects on bone remodeling. (1975) (198)
- Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor. (1988) (195)
- Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. (1996) (195)
- Effect of alendronate on fracture healing and bone remodeling in dogs (1996) (192)
- Role of alpha(v)beta(3) integrin in osteoclast migration and formation of the sealing zone. (1999) (192)
- Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats. (1990) (191)
- Mapping of MST1 Kinase Sites of Phosphorylation (2002) (186)
- Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis. (2001) (183)
- Mechanism of action of bisphosphonates (2003) (179)
- Mechanisms of action of bisphosphonates. (1998) (179)
- Characterization of the rat osteocalcin gene: stimulation of promoter activity by 1,25-dihydroxyvitamin D3. (1988) (176)
- Type β transforming growth factor (TGFβ) regulation of alkaline phosphatase expression and other phenotype‐related mRNAs in osteoblastic rat osteosarcoma cells (1987) (175)
- Nitrogen-containing bisphosphonate mechanism of action. (2004) (174)
- Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2). (2001) (173)
- Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. (2001) (172)
- Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene. (1988) (171)
- Involvement of αvβ3 integrins in osteoclast function (2007) (168)
- Opposing effects of fibroblast growth factor and pertussis toxin on alkaline phosphatase, osteopontin, osteocalcin, and type I collagen mRNA levels in ROS 17/2.8 cells. (1989) (158)
- Type-β transforming growth factor inhibits proliferation and expression of alkaline phosphatase in murine osteoblast-like cells (1986) (157)
- Glucocorticoid regulation of alkaline phosphatase in the osteoblastic osteosarcoma cell line ROS 17/2.8. (1985) (154)
- The Missing Bone (1997) (154)
- Pattern of gene expression following rat tibial marrow ablation (1993) (149)
- In vivo effects of bisphosphonates on the osteoclast mevalonate pathway. (2000) (145)
- Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy. (2006) (145)
- Estradiol regulation of insulin-like growth factor-I expression in osteoblastic cells: evidence for transcriptional control. (1991) (139)
- Inhibition of osteoclastic bone resorption in vivo by echistatin, an "arginyl-glycyl-aspartyl" (RGD)-containing protein. (1993) (139)
- Msx-2/Hox 8.1: a transcriptional regulator of the rat osteocalcin promoter. (1994) (138)
- Transcriptional regulation of osteopontin production in rat osteoblast- like cells by parathyroid hormone (1989) (137)
- NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. (1994) (137)
- Perspectives: Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption (1991) (135)
- Biphasic effects of transforming growth factor-beta on the production of osteoclast-like cells in mouse bone marrow cultures: the role of prostaglandins in the generation of these cells. (1990) (134)
- Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat bone. (1993) (130)
- Role of osteoblasts in hormonal control of bone resorption - a hypothesis. (1982) (130)
- Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins (2004) (129)
- Effects of 4‐amino‐1‐hydroxybutylidene bisphosphonate on bone biomechanics in rats (1992) (128)
- Effects of acidic and basic fibroblast growth factors on osteoblastic cells. (1989) (127)
- Tyrosine Phosphorylation of p130Cas Is Involved in Actin Organization in Osteoclasts* (1998) (123)
- Bone homeostasis. (1998) (121)
- Bone safety of long-term bisphosphonate treatment (2004) (120)
- The integrin ligand echistatin prevents bone loss in ovariectomized mice and rats. (1998) (119)
- Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor. (1989) (118)
- Rat calvarial cell lines immortalized with SV-40 large T antigen: constitutive and retinoic acid-inducible expression of osteoblastic features. (1989) (117)
- Evidence for preferential effects of parathyroid hormone, calcitonin and adenosine on bone and periosteum. (1977) (116)
- PYK2 Autophosphorylation, but Not Kinase Activity, Is Necessary for Adhesion-induced Association with c-Src, Osteoclast Spreading, and Bone Resorption* (2003) (115)
- In Vitro studies of the effect of intermittent compressive forces on cartilage cell proliferation (1979) (115)
- Impaired bone activity in aged rats: alterations at the cellular and molecular levels. (1992) (115)
- High lateral mobility of endogenous and transfected alkaline phosphatase: a phosphatidylinositol-anchored membrane protein (1987) (114)
- Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin. (1995) (113)
- Stable Association of PYK2 and p130Cas in Osteoclasts and Their Co-localization in the Sealing Zone* (1999) (113)
- Epiphyseal cartilage cAMP changes produced by electrical and mechanical perturbations. (1977) (112)
- Growth stimulation of rat calvaria osteoblastic cells by acidic fibroblast growth factor. (1987) (110)
- Mineralization of cancellous bone after alendronate and sodium fluoride treatment: a quantitative backscattered electron imaging study on minipig ribs. (1997) (110)
- Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys. (1994) (109)
- Bone mass homeostasis and bisphosphonate action. (1997) (107)
- Cyclic AMP-mediated stabilization of osteocalcin mRNA in rat osteoblast-like cells treated with parathyroid hormone. (1988) (106)
- The αvβ3 Integrin Regulates α5β1-mediated Cell Migration toward Fibronectin* (1997) (106)
- Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study. (1995) (105)
- The effect of parathyroid hormone and thyrocalcitonin on the accumulation of cyclic adenosine 3':5'-monophosphate in freshly isolated bone cells. (1974) (105)
- The effect of hemopoietic growth factors on the generation of osteoclast-like cells in mouse bone marrow cultures. (1990) (104)
- Integrin function in osteoclasts. (1997) (104)
- Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells. (1986) (101)
- Structure and expression of rat osteosarcoma (ROS 17/2.8) alkaline phosphatase: product of a single copy gene. (1988) (101)
- The bisphosphonate, alendronate, prevents bone loss in ovariectomized baboons (1992) (101)
- cDNA cloning of alkaline phosphatase from rat osteosarcoma (ROS 17/2.8) cells (1987) (100)
- Convergence of αvβ3Integrin–And Macrophage Colony Stimulating Factor–Mediated Signals on Phospholipase Cγ in Prefusion Osteoclasts (2001) (98)
- Abnormalities in membrane micro viscosity and ion transport in genetic muscular dystrophy (1975) (96)
- Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2. (1981) (94)
- Involvement of alpha(v)beta3 integrins in osteoclast function. (2007) (91)
- PYK2 is an adhesion kinase in macrophages, localized in podosomes and activated by beta(2)-integrin ligation. (2000) (90)
- Effects of sodium fluoride and alendronate on the bone mineral in minipigs: A small‐angle X‐ray scattering and backscattered electron imaging study (1996) (90)
- Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs. (1994) (89)
- Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. (2005) (89)
- Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading. (1997) (89)
- Isolation and characterization of highly enriched, prefusion mouse osteoclastic cells. (1995) (87)
- Bisphosphonate mechanism of action. (2003) (85)
- Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors (1997) (85)
- The role of calcium in the inhibition of cAMP accumulation in epiphyseal cartilage cells exposed to physiological pressure (1976) (83)
- Aminohydroxybutane bisphosphonate inhibits bone loss due to immobilization in rats (1990) (83)
- The effect of dexamethasone on parathyroid hormone stimulation of adenylate cyclase in ROS 17/2.8 cells. (1984) (79)
- Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis. (1999) (78)
- The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. (2004) (78)
- Cytochemical localization of adenylate cyclase and of calcium ion, magnesium ion-activated ATPases in the dense tubular system of human blood platelets. (1978) (77)
- Nonpeptide alphavbeta3 antagonists. 8. In vitro and in vivo evaluation of a potent alphavbeta3 antagonist for the prevention and treatment of osteoporosis. (2003) (75)
- Direct action of the parathyroid hormone-like human hypercalcemic factor on bone. (1988) (74)
- Retinoic acid increases zif268 early gene expression in rat preosteoblastic cells (1991) (73)
- IL-1 Regulates Cytoskeletal Organization in Osteoclasts Via TNF Receptor-Associated Factor 6/c-Src Complex1 (2002) (71)
- Functional estrogen receptors in osteoblastic cells demonstrated by transfection with a reporter gene containing an estrogen response element. (1991) (70)
- Nonpeptide αvβ3 Antagonists. 1. Transformation of a Potent, Integrin-Selective αIIbβ3 Antagonist into a Potent αvβ3 Antagonist (2000) (68)
- Comparison of postreceptor effects of 1-34 human hypercalcemia factor and 1-34 human parathyroid hormone in rat osteosarcoma cells. (1988) (68)
- The development and function of the skeleton and bone metastases (2003) (68)
- Nonpeptide αvβ3 Antagonists. Part 11: Discovery and Preclinical Evaluation of Potent αvβ3 Antagonists for the Prevention and Treatment of Osteoporosis (2004) (67)
- Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons (1984) (66)
- Echistatin inhibits the migration of murine prefusion osteoclasts and the formation of multinucleated osteoclast-like cells. (1998) (66)
- Soluble alpha v beta 3-integrin ligands raise [Ca2+]i in rat osteoclasts and mouse-derived osteoclast-like cells. (1994) (66)
- Alkaline phosphatase cDNA transfected cells promote calcium and phosphate deposition. (1989) (65)
- Inhibition of Osteoclast Function by Adenovirus Expressing Antisense Protein-tyrosine Kinase 2* (2001) (64)
- Regulation of Osteoclast Formation and Function* (2004) (64)
- Leukemia inhibitory factor suppresses proliferation, alkaline phosphatase activity, and type I collagen messenger ribonucleic acid level and enhances osteopontin mRNA level in murine osteoblast-like (MC3T3E1) cells. (1990) (63)
- Interrelationships between Ca2+ and adenylate and guanylate cyclases in the control of platelet secretion and aggregation. (1976) (63)
- Coupling of Bone Resorption and Formation during Bone Remodeling (2001) (62)
- Sphingosine kinase mediates cyclic AMP suppression of apoptosis in rat periosteal cells. (1998) (61)
- Diversity of the osteoblastic phenotype. (1988) (61)
- Osteopontin Overview (1995) (60)
- Type beta transforming growth factor regulates expression of genes encoding bone matrix proteins. (1989) (59)
- Maintenance of parathyroid hormone response in clonal rat osteosarcoma lines. (1978) (59)
- Human protein tyrosine phosphatase‐σ: Alternative splicing and inhibition by bisphosphonates (1996) (58)
- Membrane changes during cartilage maturation. Increase in 5'- nucleotidase and decrease in adenosine inhibition of adenylate cyclase (1977) (58)
- Control of bone formation and resorption: biological and clinical perspective. (1998) (57)
- Expression of αv and β3 integrin subunits in rat osteoclasts in situ (1993) (55)
- Effects of a potent carbonic anhydrase inhibitor on bone resorption in organ culture. (1988) (54)
- Leukemia inhibitory factor binds with high affinity to preosteoblastic RCT-1 cells and potentiates the retinoic acid induction of alkaline phosphatase. (1990) (54)
- Bisphosphonates in the treatment of metabolic bone diseases. (1993) (53)
- Expression of the prostaglandin E2 (PGE2) receptor subtype EP4 and its regulation by PGE2 in osteoblastic cell lines and adult rat bone tissue1 (2001) (51)
- Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts. (2001) (51)
- Effects of retinoic acid on alkaline phosphatase messenger ribonucleic acid, catecholamine receptors, and G proteins in ROS 17/2.8 cells. (1988) (50)
- Parathyroid hormone promotes the disassembly of cytoskeletal actin and myosin in cultured osteoblastic cells: Mediation by cyclic AMP (1991) (50)
- Alkaline phosphatase inhibition by parathyroid hormone and isoproterenol in a clonal rat osteosarcoma cell line. Possible mediation by cyclic AMP (2006) (48)
- Stimulation of Mouse Osteopontin Promoter by v-Src Is Mediated by a CCAAT Box-binding Factor* (1996) (48)
- Histomorphometric evidence for echistatin inhibition of bone resorption in mice with secondary hyperparathyroidism. (1998) (47)
- Evidence for a direct effect of estrogen on bone cells in vitro. (1990) (46)
- Prostaglandin E2 (PGE2) increases the number of rat bone marrow osteogenic stromal cells (BMSC) via binding the EP4 receptor, activating sphingosine kinase and inhibiting caspase activity. (2006) (46)
- The activity of membrane bound enzymes in muscular dystrophic chicks (1974) (44)
- Integrin-mediated signaling in the regulation of osteoclast adhesion and activation. (1998) (44)
- Thiazolidinedione effects on glucocorticoid receptor-mediated gene transcription and differentiation in osteoblastic cells. (1999) (44)
- Expression and regulation of vascular endothelial growth factor in osteoblasts. (1995) (44)
- Depression of osteoblastic activity in immobilized limbs of suckling rats (1991) (42)
- Demonstration of adenylate cyclase activity in human red blood cell ghosts. (1976) (41)
- Long-term safety of the aminobisphosphonate alendronate in adult dogs. II. Histomorphometric analysis of the L5 vertebrae. (1996) (40)
- Role of α v β 3 integrin in osteoclast migration and formation of the sealing zone (1999) (40)
- Alendronate inhibition of protein-tyrosine-phosphatase-meg1. (1997) (39)
- Nonpeptide αvβ3 antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide (2002) (38)
- Systemic administration of an anabolic dose of prostaglandin E2 induces early-response genes in rat bones. (1997) (38)
- Soluble αvβ3-integrin ligands raise [Ca2+] in rat osteoclasts and mouse-derived osteoclast-like cells (1994) (37)
- Preclinical pharmacology of alendronate (2005) (36)
- Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands (2009) (35)
- Type beta transforming growth factor (TGF beta) regulation of alkaline phosphatase expression and other phenotype-related mRNAs in osteoblastic rat osteosarcoma cells. (1987) (35)
- Prostaglandin Receptor EP4 Mediates the Bone Anabolic Effects of PGE2 (2001) (35)
- Alkaline phosphatase as a reporter enzyme. (1988) (34)
- Osteogenic protein-1 up-regulation of the collagen X promoter activity is mediated by a MEF-2-like sequence and requires an adjacent AP-1 sequence. (1997) (34)
- Retinoic acid stimulates transcriptional activity from the alkaline phosphatase promoter in the immortalized rat calvarial cell line, RCT-1. (1992) (33)
- IL-1 binds to high affinity receptors on human osteosarcoma cells and potentiates prostaglandin E2 stimulation of cAMP production. (1990) (32)
- Regulatory mechanism of osteoclast activation. (2003) (32)
- Estrogenic control of thermoregulation in ERαKO and ERβKO mice (2006) (31)
- The role of prostaglandins in bone formation. (1995) (31)
- Expression of the prostaglandin E(2) (PGE(2)) receptor subtype EP(4) and its regulation by PGE(2) in osteoblastic cell lines and adult rat bone tissue. (2001) (30)
- The effect of calcium concentration on calcium uptake by bone cells treated with thyrocalcitonin (TCT) hormone. (1973) (29)
- Non-peptide αvβ3 antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl β-amino acids as aspartic acid replacements (2002) (28)
- The role of integrins in osteoclast function (1999) (27)
- Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family (1999) (27)
- M-CSF induces the stable interaction of cFms with αvβ3 integrin in osteoclasts (2006) (27)
- Alendronate and osteoporosis (1998) (27)
- The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. (2010) (27)
- BisphosphonatesMechanisms of Action (2002) (26)
- Type-beta transforming growth factor inhibits proliferation and expression of alkaline phosphatase in murine osteoblast-like cells. (1986) (26)
- Distinct roles of p130Cas and c-Cbl in adhesion-induced or macrophage colony-stimulating factor-mediated signaling pathways in prefusion osteoclasts. (2003) (26)
- Rat alkaline phosphatase. II. Structural similarities between the osteosarcoma, bone, kidney, and placenta isoenzymes. (1987) (25)
- Unidirectional migration of osteosarcoma cells with osteoblast characteristics in response to products of bone resorption (2006) (25)
- Rat tail skin temperature regulation by estrogen, phytoestrogens and tamoxifen. (2004) (25)
- Osteoporosis and bisphosphonates. (2003) (25)
- Non-Peptide αvβ3 Antagonists. Part 4: Potent and Orally Bioavailable Chain-Shortened RGD Mimetics (2002) (24)
- Clonal differences in prostaglandin synthesis among osteosarcoma cell lines (1986) (24)
- The aminobisphosphonate alendronate inhibits bone loss induced by thyroid hormone in the rat. Comparison between effects on tibiae and vertebrae. (1993) (24)
- Disintegration and Esophageal Irritation Profiles of Alendronate Formulations:Implications for Clinical Safety and Efficacy (2005) (23)
- Identification of a rat osteocalcin promoter 3',5'-cyclic adenosine monophosphate response region containing two PuGGTCA steroid hormone receptor binding motifs. (1995) (23)
- Endogenous calcitonin attenuates parathyroid hormone-induced cancellous bone loss in the rat. (1995) (22)
- Microtubule disruption enhances prostaglandin E2 production in osteoblastic cells. (1987) (22)
- Parathyroid hormone and prostaglandin E2 preferentially increase luciferase levels in bone of mice harboring a luciferase transgene controlled by elements of the pro-α1(I) collagen promoter (2000) (22)
- Localization of adenylate cyclase in skeletal muscle sarcoplasmic reticulum and its relation to calcium accumulation (1978) (21)
- Comparison of bone and osteosarcoma adenylate cyclase. Effects of Mg2+, Ca2+, ATP4- and HATP3- in the assay mixture. (1980) (21)
- Non-peptide αvβ3 antagonists. Part 7: 3-Substituted tetrahydro-[1,8]naphthyridine derivatives (2004) (21)
- Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. (1996) (21)
- Bisphosphonates and primary hyperparathyroidism. (2002) (21)
- Identification of fatty acid methyl ester as naturally occurring transcriptional regulators of the members of the peroxisome proliferator-activated receptor family (1996) (19)
- Non-peptide alpha(v)beta(3) antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl beta-amino acids as aspartic acid replacements. (2002) (19)
- Role of cAMP in the release from dormancy of freshwater sponge gemmules. (1976) (19)
- Estrogenic control of thermoregulation in ERalphaKO and ERbetaKO mice. (2006) (18)
- Expression of alpha v and beta 3 integrin subunits in rat osteoclasts in situ. (1993) (18)
- Rat alkaline phosphatase. I. Purification and characterization of the enzyme from osteosarcoma: generation of monoclonal and polyclonal antibodies. (1987) (18)
- Cloning and analysis of the 5' region of the rat bone/liver/kidney/placenta alkaline phosphatase gene. A dual-function promoter. (1990) (17)
- Glucocorticoid treatment facilitates cyclic adenosine 3',5'-monophosphate-dependent protein kinase response in parathyroid hormone-responsive osteogenic sarcoma cells. (1986) (17)
- Preclinical safety profile of alendronate. (1999) (17)
- Parathyroid hormone stimulation of adenylate cyclase activity and lactic acid accumulation in calvaria of osteopetrotic (ia) rats. (1978) (17)
- Agonist-like SERM effects on ERα-mediated repression of MMP1 promoter activity predict in vivo effects on bone and uterus (2008) (16)
- Parathyroid hormone and isoproterenol stimulation of adenylate cyclase in rat osteosarcoma clonal cells. Hormone competition and site heterogeneity. (1981) (16)
- The effects of the aminobisphosphonate alendronate on thyroid hormone-induced osteopenia in rats (1993) (15)
- Immobilization-related bone loss in the rat is increased by calcium deficiency (1991) (15)
- Adenylate cyclase enhancing factor from rat osteosarcoma cytosol. (1978) (15)
- Control of rat tail skin temperature regulation by estrogen receptor-beta selective ligand. (2009) (15)
- Antagonist-induced, activation function-2-independent estrogen receptor α phosphorylation (2006) (15)
- ADENYLATE CYCLASE IN MUSCULAR DYSTROPHY * (1979) (14)
- Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis. (2004) (14)
- Characterization of retinoic acid- and cell-dependent sequences which regulate zif268 gene expression in osteoblastic cells. (1994) (14)
- A quantitative method for the application of compressive forces to bone in tissue culture (1975) (13)
- Adenylate cyclase and ATPase activities in red cell membranes of patients and genetic carriers of Duchenne muscular dystrophy. (1979) (13)
- Nonpeptide αvβ3 antagonists : identification of potent, chain-shortened 7-oxo RGD mimetics (2005) (12)
- 11 – Bone Cell Shape and Function (1989) (12)
- Preclinical evidence of normal bone with alendronate. (1999) (12)
- Thionapthene-2-carboxylic acid: a new antihypercalcemic agent. (1985) (12)
- Effects of sodium fluoride and alendronate on the bone mineral in minipigs. I. A small-angle X-ray scattering study (1995) (12)
- M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts. (2006) (12)
- Effects of diabetes and insulin on bone metabolism (1996) (11)
- Alendronate inhibition of protein tyrosine phosphatase activity (1995) (11)
- Nonpeptide αvβ3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone (2004) (11)
- In vitro characterization and in vivo efficacy of a prostaglandin E2/poly(ortho ester) implant for bone growth promotion (1993) (11)
- Non-peptide αvβ3 antagonists: Identification of potent, chain-shortened RGD mimetics that incorporate a central pyrrolidinone constraint (2003) (11)
- Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation. (2006) (10)
- Enhancement of ornithine decarboxylase and Na+, K+ ATPase in osteoblastoma cells by intermittent compression. (1981) (9)
- SV-40 large-T immortalization of embryonic bone cells: establishment of osteoblastic clonal cell lines. (1989) (9)
- Regulation of creatine kinase activity in rat osteogenic sarcoma cell clones by parathyroid hormone, prostaglandin E2, and vitamin D metabolites (1985) (8)
- Chapter 28. Emerging Therapies in Osteoporosis (1994) (8)
- The Effect of Electromagnetic Fields on Receptor-Ligand Interaction: A Theoretical Analysis (1984) (8)
- Nonpeptide αvβ3 antagonists. Part 10: In vitro and in vivo evaluation of a potent 7-methyl substituted tetrahydro-[1,8]naphthyridine derivative (2004) (8)
- Cross-talk between an activator of nuclear receptors-mediated transcription and the D1 dopamine receptor signaling pathway (2005) (8)
- Development of selective androgen receptor modulators and their therapeutic applications. (2002) (8)
- Comparison of the therapeutic potencies of two bisphosphonates (1992) (8)
- Osteosarcoma cytosol factor promotes parathyroid hormone stimulation of adenylate cyclase independent of GTP. (1980) (8)
- Abnormal localisation and hyperclustering of α V β 3 integrins and associated proteins in Src-deficient or tyrphostin A 9-treated osteoclasts (2000) (8)
- Chapter 78 – Bisphosphonates: Mechanisms of Action (2002) (8)
- Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist. (2000) (7)
- Estradiol enhances insulin-like growth factor I mRNA and has anabolic effects in osteoblastic cells from rat calvariae and long bones (1990) (7)
- Cytochemical evidence for the segregation of adenylate cyclase, Ca2+-, Mg2+-ATPase, K+-dependentp-nitrophenyl phosphatase in separate membrane compartments in human platelets (1981) (6)
- Formation of calcifying matrix by osteosarcoma cells in diffusion chambersin vivo (1986) (6)
- A model for investigating the local action of bone-acting agentsIn vivo: Effects of hPTH(1–34) on the secondary spongiosa in the rat (1990) (6)
- Inhibition of cAMP accumulation in epiphyseal cartilage cells exposed to physiological pressure (1975) (5)
- Calcium binding to nondialyzable components of rat blood under in vivo conditions. (1973) (5)
- A Tumor‐Secreted Protein Associated with Human Hypercalcemia of Malignancy (1988) (5)
- Phenotypic maturation of osteoblastic osteosarcoma cells in culture. (1982) (5)
- RECENT INVESTIGATIONS OF THE INVOLVEMENT OF 3′, 5′ CYCLIC AMP IN THE DEVELOPMENTAL PHYSIOLOGY OF SPONGE GEMMULES (1976) (5)
- Integrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of Osteoclasts (2002) (5)
- The Kroc Foundation Conference on Functional Adaptation in Bone Tissue (1984) (5)
- Identification of an AP1-like response region for osteogenic protein-1 in type X collagen promoter. (1996) (5)
- Comparison of bone and osteosarcoma adenylate cyclase. Partial purification of membranes and kinetic properties of enzyme. (1980) (5)
- Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide. (2002) (5)
- Chapter 73 – Pathophysiology of Osteoporosis (2002) (4)
- Polymalonic acid as boneaffinity agent (1989) (4)
- Non-peptide alpha(v)beta(3) antagonists: identification of potent, chain-shortened RGD mimetics that incorporate a central pyrrolidinone constraint. (2003) (4)
- Chapter 15 – CELLULAR FUNCTIONS OF CALCIUM (1973) (4)
- In vivo effects of thyroid hormones on bone metabolism in adult mice (1992) (4)
- Alendronate: Preclinical Studies (1997) (4)
- Good hope for making osteoporosis a disease of the past (2005) (4)
- Alendronate (ALN) increases the membrane permeability of multinucleated osteoclast-like cells to NH4+, H+ AND Ca++ (1992) (4)
- Parathyroid hormone and prostaglandin E2 preferentially increase luciferase levels in bone of mice harboring a luciferase transgene controlled by elements of the pro-alpha1(I) collagen promoter. (2000) (3)
- Effect of alendronate (bisphosphonate) in animal models of hyperparathyroidism. (1991) (3)
- Response sequences for estrogen, EGF and TGFβ in the human PTHrP gene overlap with sites for either NF-1 or SP-1 (1992) (3)
- Anabolic Steroid Effects on Bone in Women (2002) (3)
- The Mechanism of Action of Nitrogen-Containing Bisphosphonates (2003) (3)
- Non-peptide alpha v beta 3 antagonists. Part 7: 3-Substituted tetrahydro-naphthyridine derivatives. (2004) (3)
- The family of osteoblast transcription factors is growing (2005) (3)
- Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements. (2002) (3)
- Effects of Calcium on Adenylate Cyclase, as Part of the Ca2+-cAMP Feedback in Biological Communication (1978) (3)
- Hormone-adenylate cyclase coupling in osteosarcoma clonal cell lines. (1984) (3)
- The role of Mg2+ in hormone stimulation of rat osteosarcoma adenylate cyclase. (1981) (2)
- Nonpeptide αvβ3 Antagonists: Identification of Potent, Chain‐Shortened 7‐Oxo RGD Mimetics. (2005) (2)
- Letter to the editor (2006) (2)
- Poster abstractAlendronate (ALN) increases the membrane permeability of multinucleated osteoclast-like cells to NH4+,H+ and Ca++ (1992) (2)
- CHAPTER 20 – Intercellular Communication during Bone Remodeling (2008) (2)
- Meeting report from the IOF world congress on osteoporosis (2002) (1)
- Treatment of bone in elderly subjects: calcium, vitamin D, fluor, bisphosphonates, calcitonin. (1996) (1)
- Non-peptide alpha(v)beta(3) antagonists. Part 4: potent and orally bioavailable chain-shortened RGD mimetics. (2002) (1)
- Translocation of phosphatidylinositol-3 kinase (PI3-kinase) and small GTPase rho A to the cytoskeleton upon osteoclast attachment to bone (1995) (1)
- The differential pattern of gene expression during bone remodelling following rat tibial marrow ablation (1992) (1)
- Oral abstractOsteoblastic cells (1992) (1)
- Function and regulation of cathepsin K in bone (2001) (1)
- Identification of a novel retinoic acid responsive sequence in the alkaline phosphatase gene (1992) (1)
- Effects of thionapthene 2-carboxylic acid and related compounds on bone resorption in organ culture (1985) (1)
- Nonpeptide alpha V beta 3 antagonists. Part 10: In vitro and in vivo evaluation of a potent 7-methyl substituted tetrahydro-[1,8]naphthyridine derivative. (2004) (0)
- Meeting announcement (2006) (0)
- The differentiation and function of the osteoblast (1990) (0)
- New secrets unveiled by the big /`N FAT osteoclast (2003) (0)
- Expression of osteopontin mRNA in paraffin sections of demineralized bone specimens from sexually mature female rat (1992) (0)
- Hybrydization histochemistry in bone: A perspective (1992) (0)
- Nonpeptide alpha(v)beta3 antagonists: identification of potent, chain-shortened 7-oxo RGD mimetics. (2005) (0)
- Experimental studies with aminohydroxybutylidene bisphosphonate (ABBP) (1990) (0)
- Factor 6 / cSrc Complex Osteoclasts Via TNF Receptor-Associated IL-1 Regulates Cytoskeletal Organization in (2002) (0)
- Chairman's Summary (2007) (0)
- and Macrophage Colony Stimulating Factor–mediated Signals on Phospholipase C g in Prefusion Osteoclasts (2001) (0)
- Partial Purification of Plasma Membranes from Calcified Connective Tissues (1979) (0)
- Skeletal Complications of Malignancy Supplement to Cancer The Development and Function of the Skeleton and Bone Metastases (0)
- Cumulative Index to Volume 67 (2011) (0)
- The osteoblastic cytoskeleton and hormone action (1986) (0)
- Calcium homeostasis at the tissue level (2005) (0)
- Development of Alendronate (Preclinical Studies) (1996) (0)
- Neoplasia and mineral metabolism (2007) (0)
- Index for Volumes 1 and 2 (1963) (0)
- Osteoblast Phenotypic Expression and Bone Markers (1989) (0)
- Bone marrow and osteogenesis (2007) (0)
- The effect of two years alendronate treatment on biochemical markers of bone metabolism in ovariectomized baboons (1992) (0)
- HUMANE protein tyrosine phosphatase DECODE END cDNA (1994) (0)
- Mechanical perturbation or microtubule disruption enhance PGE synthesis in bone cells (keynote lecture) (1986) (0)
- Retinoic acid-regulation of alkaline phosphatase in RCT-1 cells (1990) (0)
- Nonpeptide alpha V beta 3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone. (2004) (0)
- Novel prohibition of bone resorption (1992) (0)
- 528 DISEASE MODIFYING EFFECTS OF A CATHEPSIN K INHIBITOR IN THE RABBIT ANTERIOR CRUCIATE LIGAMENT TRANSECTION MODEL OF OSTEOARTHRITIS (2009) (0)
- Methodes et compositions de traitement d'une parodontopathie (2001) (0)
- 8. Gene expression in osteoblast cells (1994) (0)
- Alendronate and risedronate but not etidronate inhibit bone resorption without inducing apoptosis (1999) (0)
- Characterization of the osteogenic protein-1 response region in the type X collagen promoter (1995) (0)
- PTH-Like Tumor Hypercalcemia Factor (1989) (0)
- Osteogenic growth factors are identified from regenerating bone marrow to (1990) (0)
- Alendronate: preclinical studies. (1997) (0)
- Methode d'inhibition de la resorption osseuse (1992) (0)
- Contents, Vol. 45, 1996 (1996) (0)
- Procedes d'identification de composes servant a inhiber la farnesyle diphosphate synthase (2000) (0)
- Effects of sodium fluoride and alendronate on the bone mineral in minipigs. II. A quantitative backscattered electron imaging study (1995) (0)
- Structure and expression of rat osteosarcoma ( ROS 17 / 2 . 8 ) alkaline phosphatase : Product of a single copy gene ( isozyme / transfection / tissue expression ) (2003) (0)
- Autocrine/paracrine regulation of osteoblast growth and differentiation. (1991) (0)
- Subject Index Vol. 45, 1996 (1996) (0)
- Prostaglandin analogs for the treatment of osteoporosis (1993) (0)
- Differentiation-dependent effects of dexamethasone on osteopontin mRNA expression in bone-derived cells (1992) (0)
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