G. David Roodman
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G. David Roodman's Degrees
- Bachelors Biology Stanford University
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(Suggest an Edit or Addition)G. David Roodman's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cell biology of the osteoclast. (1999) (595)
- Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma. (2007) (453)
- Pathogenesis of myeloma bone disease (2009) (411)
- Advances in bone biology: the osteoclast. (1996) (405)
- Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone. (1992) (360)
- Theoretical perspective: A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates (1996) (341)
- Biology of osteoclast activation in cancer. (2001) (322)
- Intracellular Fragmentation of Bone Resorption Products by Reactive Oxygen Species Generated by Osteoclastic Tartrate-resistant Acid Phosphatase* (1999) (266)
- Perspectives: Interleukin‐6: An osteotropic factor? (1992) (256)
- Effects of human recombinant CSF‐GM and highly purified CSF‐1 on the formation of multinucleated cells with osteoclast characteristics in long‐term bone marrow cultures (1986) (213)
- A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. (2010) (190)
- Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice. (1989) (189)
- Interleukin-6: a potential mediator of the massive osteolysis in patients with Gorham-Stout disease. (1996) (185)
- Mechanisms of bone lesions in multiple myeloma and lymphoma (1997) (178)
- Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone. (2000) (165)
- Paget disease of bone. (2005) (161)
- Genetic linkage of Paget disease of the bone to chromosome 18q. (1997) (160)
- Tumor necrosis factor-alpha and hematopoietic progenitors: effects of tumor necrosis factor on the growth of erythroid progenitors CFU-E and BFU-E and the hematopoietic cell lines K562, HL60, and HEL cells. (1987) (156)
- Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype. (2000) (136)
- Chemokines in multiple myeloma. (2006) (133)
- In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. (2010) (129)
- IL‐6 Mediates the Effects of IL‐1 or TNF, but Not PTHrP or 1,25(OH)2D3, on Osteoclast‐like Cell Formation in Normal Human Bone Marrow Cultures (1998) (128)
- Bone marrow mononuclear cells from patients with Paget's disease contain measles virus nucleocapsid messenger ribonucleic acid that has mutations in a specific region of the sequence. (1995) (121)
- Osteotropic factor responsiveness of highly purified populations of early and late precursors for human multinucleated cells expressing the osteoclast phenotype (1991) (121)
- RANK ligand as a therapeutic target for bone metastases and multiple myeloma. (2008) (119)
- Downregulation of calcitonin receptor mRNA expression by calcitonin during human osteoclast-like cell differentiation. (1995) (116)
- Interleukin-6: an osteotropic factor? (1992) (116)
- Legumain Expression in Relation to Clinicopathologic and Biological Variables in Colorectal Cancer (2005) (115)
- Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone. (1998) (114)
- Metastasis and bone loss: advancing treatment and prevention. (2010) (112)
- ADAM8: A Novel Osteoclast Stimulating Factor (2001) (109)
- Identification of Human Asparaginyl Endopeptidase (Legumain) as an Inhibitor of Osteoclast Formation and Bone Resorption* (1999) (107)
- Myeloma bone disease. (2001) (106)
- Sequence Analysis of Measles Virus Nucleocapsid Transcripts in Patients with Paget's Disease (2002) (102)
- Osteoclast differentiation. (1991) (100)
- The science and practice of bone health in oncology: managing bone loss and metastasis in patients with solid tumors. (2009) (100)
- Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. (1994) (98)
- Detection of measles virus nucleocapsid transcripts in circulating blood cells from patients with paget disease (1996) (95)
- Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures. (1999) (93)
- Characterization of the mouse tartrate‐resistant acid phosphatase (trap) gene promoter (1995) (90)
- 1,25‐Dihydroxyvitamin D3 Hypersensitivity of Osteoclast Precursors from Patients with Paget's Disease (2000) (88)
- Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease. (1990) (86)
- Pathophysiology of myeloma bone disease. (2007) (81)
- Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia. (2010) (78)
- Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. (2000) (77)
- Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts. (2001) (75)
- Osteoclast-like cells form in long-term human bone marrow but not in peripheral blood cultures. (1989) (74)
- Expansile Skeletal Hyperphosphatasia: A New Familial Metabolic Bone Disease (2000) (72)
- Osteoblast function in myeloma. (2011) (71)
- Multinucleated cells formed in vitro from Paget's bone marrow express viral antigens. (1994) (67)
- Advancing Treatment for Metastatic Bone Cancer: Consensus Recommendations from the Second Cambridge Conference (2008) (65)
- Antibodies to Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. (1998) (63)
- Interleukin‐6 antisense deoxyoligonucleotides inhibit bone resorption by giant cells from human giant cell tumors of bone (1994) (62)
- Control of osteoclast differentiation. (1998) (60)
- Pathogenesis of myeloma bone disease. (2004) (60)
- Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment. (2010) (60)
- Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation. (2008) (59)
- Role of TAFII‐17, a VDR Binding Protein, in the Increased Osteoclast Formation in Paget's Disease (2004) (58)
- Skeletal imaging and management of bone disease. (2008) (58)
- Phase I Trial of Bortezomib (PS-341; NSC 681239) and Alvocidib (Flavopiridol; NSC 649890) in Patients with Recurrent or Refractory B-Cell Neoplasms (2011) (56)
- Paget disease of bone. (2018) (56)
- Transcriptional regulation of the tartrate-resistant acid phosphatase (TRAP) gene by iron. (1994) (55)
- SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-kappaB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth. (2007) (53)
- Annexin II Stimulates RANKL Expression Through MAPK (2005) (53)
- Inhibition of erythroid colony formation by autologous bone marrow adherent cells from patients with the anemia of chronic disease. (1983) (52)
- Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption (1998) (52)
- Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice. (1998) (51)
- Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche. (2011) (50)
- Paget's disease and osteoclast biology. (1996) (49)
- Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts. (1995) (48)
- Cloning and characterization of the 5′‐flanking region of the mouse tartrate‐resistant acid phosphatase gene (1993) (47)
- Paget's Disease of Bone: A Disease of the Osteoclast (2004) (46)
- Erratum to ?Pathogenesis of myeloma bone disease? 6Blood Cells Mol. Dis. 32 (2004) 290?2929 (2004) (45)
- Measles virus nucleocapsid transcript expression is not restricted to the osteoclast lineage in patients with Paget's disease of bone. (1999) (44)
- Targeting the bone microenvironment in multiple myeloma (2010) (44)
- Osteoclast function in Paget's disease and multiple myeloma. (1995) (44)
- Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection (1989) (43)
- Pathophysiology of multiple myeloma bone disease. (2007) (43)
- MIP-1 alpha and myeloma bone disease. (2004) (41)
- Functional Role for Heat Shock Factors in the Transcriptional Regulation of Human RANK Ligand Gene Expression in Stromal/Osteoblast Cells* (2004) (41)
- Insights into the pathogenesis of Paget's disease (2010) (41)
- Role of stromal-derived cytokines and growth factors in bone metastasis. (2003) (39)
- Treatment strategies for bone disease (2007) (39)
- Erythropoietin fails to reverse the anemia in mice continuously exposed to tumor necrosis factor-alpha in vivo. (1990) (38)
- New Potential Targets for Treating Myeloma Bone Disease (2006) (38)
- Development and characterization of a human marrow stromal cell line that enhances osteoclast-like cell formation. (1995) (36)
- Bone building with bortezomib. (2008) (36)
- Comparison of engraftment and acute GVHD in patients undergoing cryopreserved or fresh allogeneic BMT. (1993) (36)
- Inhibition of tartrate-resistant acid phosphatase gene expression by hemin and protoporphyrin IX. Identification of a hemin-responsive inhibitor of transcription. (1996) (34)
- Characterization of the osteoclast vacuolar H(+)-ATPase B-subunit. (1995) (31)
- Osteoclast‐like cell formation in fetal and newborn long‐term baboon marrow cultures is more sensitive to 1,25‐dihydroxyvitamin D3 than adult long‐term marrow cultures (1987) (29)
- Advances in Treating Metastatic Bone Cancer: Summary Statement for the First Cambridge Conference (2006) (29)
- Cloning and identification of human Sca as a novel inhibitor of osteoclast formation and bone resorption. (1998) (28)
- The Genetics of Paget’s Disease of the Bone (2001) (27)
- DNA polymerase activities during erythropoiesis. Effects of erythropietin, vinblastine, colcemid, and daunomycin. (1975) (25)
- Novel targets for myeloma bone disease. (2008) (25)
- In utero bone marrow transplantation of fetal baboons with mismatched adult baboon marrow. (1991) (25)
- In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development. (2009) (24)
- Studies in Paget's disease and their relevance to oncology. (2001) (24)
- DNA polymerase, thymidine kinase and DNA synthesis in erythropoietic mouse spleen cells separated on bovine serum albumin gradients. (1976) (24)
- The Pro and Con of Measles Virus in Paget's Disease: Pro (2002) (24)
- Characterization of the 5'-flanking region of the human tartrate-resistant acid phosphatase (TRAP) gene. (1995) (24)
- Phase I Trial of Bortezomib (PS-341; NSC 681239) and “Nonhybrid” (Bolus) Infusion Schedule of Alvocidib (Flavopiridol; NSC 649890) in Patients with Recurrent or Refractory Indolent B-cell Neoplasms (2014) (23)
- Animal models of bone disease (1998) (23)
- Genetics of endocrine disease: The genetics of paget's disease of the bone (2001) (21)
- Mechanisms of erythroid suppression in the anemia of chronic disease. (1987) (21)
- Osteoclasts pump iron. (2009) (21)
- Eosinophil Chemotactic Factor‐L (ECF‐L): A Novel Osteoclast Stimulating Factor (2003) (20)
- High bone turnover markers predict poor outcome in patients with bone metastasis. (2005) (20)
- Assignment of the mouse tartrate-resistant acid phosphatase gene (Acp5) to chromosome 9. (1993) (19)
- CFU-GEMM correlate with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high-dose melphalan chemotherapy. (1987) (18)
- Endogenous erythroid colony-forming cells in fetal and newborn sheep. (1979) (18)
- Effects of dexamethasone on erythroid colony and burst formation from human fetal liver and adult marrow (1983) (18)
- Characterization of immortalized osteoclast precursors developed from mice transgenic for both bcl-X(L) and simian virus 40 large T antigen. (1999) (18)
- Bone-breaking cancer treatment (2007) (17)
- Tumor necrosis factor alpha and the anemia of chronic disease: effects of chronic exposure to TNF on erythropoiesis in vivo. (1989) (17)
- Perspective on the Osteoclast (2007) (17)
- Cokeromyces recurvatus infection in a bone marrow transplant recipient (1997) (16)
- Experimental Models of Paget's Disease (2006) (15)
- Phase I trial of dacarbazine with cyclophosphamide, carmustine, etoposide, and autologous stem-cell transplantation in patients with lymphoma and multiple myeloma. (1994) (15)
- The role of bisphosphonates in multiple myeloma (2009) (14)
- Perspective on the osteoclast: an angiogenic cell? (2007) (13)
- Mechanisms of abnormal bone turnover in Paget's disease. (1999) (12)
- Hemin-induced erythroid differentiation changes the sensitivity of K562 cells to tumor necrosis factor-alpha. (1989) (11)
- In utero bone marrow transplantation of fetal baboons with mismatched adult marrow: initial observations. (1988) (10)
- Novel targets for myeloma bone disease (2008) (10)
- Autoimmune pancytopenia. Lymphocyte inhibition of autologous but not allogenic bone marrow growth in vitro. (1980) (10)
- Stimulation of erythroid colony formation in vitro by erythropoietin immobilized on agarose-bound lectins. (1981) (9)
- Effects of TNF and lymphotoxin on bone cells. (1992) (8)
- The genetics of Paget's disease of the bone. (2001) (7)
- Osteoclast Differentiation (2006) (7)
- Osteoclast differentiation and activity. (1998) (7)
- Chapter 72. Paget's Disease of Bone (2009) (7)
- Effects of Shortened Erythropoietin Exposure on Sheep Marrow Cultures (1981) (7)
- Growth regulatory factors and bone cell function (1990) (7)
- Further characterization of the murine collagenase (type IVB) gene promoter and analysis of mRNA expression in murine tissues. (1998) (7)
- Mechanisms of bone resorption in myeloma. (2003) (6)
- Multiple Myeloma Cell Induction of GFI-1 in Stromal Cells Suppresses Osteoblast Differentiation in Patients with Myeloma. (2009) (6)
- Tartrate-resistant acid phosphatase gene expression as a facile reporter gene for screening transfection efficiency in mammalian cell cultures. (1993) (6)
- Biology of the osteoclast in Paget's disease. (1994) (5)
- A phase I clinical and pharmacological profile of dacarbazine with autologous bone marrow transplantation in patients with solid tumors (1993) (5)
- Mixed lymphocyte culture reactivity of fetal baboons: application for in utero bone marrow transplantation. (1990) (5)
- Assignment of matrix metalloproteinase 9 (Mmp9) to mouse chromosome 2 bands H1-H2. (1996) (4)
- p62: A Potential Target for Blocking Microenvironmental Support of Myeloma (2009) (4)
- Clinical Presentation of Myeloma Bone Disease (2010) (4)
- Bone metastasis [5] (multiple letters) (2004) (4)
- Mechanisms of Osteolytic and Osteoblastic Skeletal Lesions (2018) (4)
- Paget’s Disease of Bone (1991) (4)
- Book Review Textbook of Bone Metastases Edited by Claude Jasmin, Robert E. Coleman, Lawrence R. Coia, Rodolfo Capanna, and Gérard Saillant. 568 pp., illustrated. Chichester, England, John Wiley & Sons, 2005. $350. 0-471-87742-5 (2005) (3)
- A phase I-II clinical trial with a combination of gemcitabine (GEMZAR) and paclitaxel (TAXOL) for the treatment of refractory multiple myeloma (MM) patients (2000) (3)
- Targeting CDK4/CDK6 Impairs Osteoclast Progenitor Pool Expansion and Blocks Osteolytic Lesion Development in Multiple Myeloma. (2009) (3)
- Role of Bone Disease in the Pathogenesis of Multiple Myeloma (2013) (3)
- Combination of the mTOR Inhibitor Rapamycin with the HSP90 Inhibitor 17-AAG Has Synergistic Activity in EBV Positive Post Transplant Lymphoproliferative Disorders (PTLD). (2005) (3)
- Nutritional parameters observed during 28-day infusion of recombinant human tumor necrosis factor-alpha. (1993) (3)
- Aplastic anemia associated with rubber cement used by a marathon runner. (1980) (3)
- New opportunities for the management of cancer-related bone complications. (2009) (3)
- Therapeutic Options in Multiple Myeloma: Focus on Bortezomib (2009) (3)
- Assignment1 of OSTF1 to human chromosome bands 12q24.1→q24.2 by in situ hybridization (2000) (3)
- 80. Paget's Disease of Bone (2013) (2)
- Myeloma bone disease: pathogenesis and treatment. (2005) (2)
- Pagetic osteoclasts formed in vitro: absence of paracrystalline inclusions. (1998) (2)
- Proteomic Analysis of Waldenstrom Macroglobulinemia (WM) Using Nanoscale Protein Micorarray Techniques. (2005) (2)
- Chapter 80. Hematologic Malignancies and Bone (2009) (2)
- Induction of differentiation of the human promyelocytic HL-60 cells into cells with the osteoclastic phenotype (1990) (2)
- Treatment of Multiple Myeloma and Related Disorders: DIAGNOSIS AND TREATMENT OF MYELOMA BONE DISEASE (2008) (2)
- Erratum: Pathogenesis of myeloma bone disease (Blood Cells, Molecules, and Diseases (2004) 32 (290-292) DOI: 10.1016/j.bcmd.2004.01.001) (2004) (2)
- Combination of the AKT Inhibitor Perifosine with the HSP90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin (17-DMAG) Has Synergistic Activity in Multiple Myeloma (MM). (2005) (2)
- Application of bone marrow cultures to the study of osteoclast formation and osteoclast precursors in man. (1995) (2)
- Expression of latent hematopoietic progenitor cells in cultures of newborn and adult baboon liver. (1985) (2)
- The science and practice of bone health in oncology (2009) (2)
- Cathepsin G, a Potent Platelet Aggregation Activator, Is Upregulated in Multiple Myeloma Patients during Treatment with Lenalidomide (Revlimid). (2007) (2)
- The Role of the AKT Inhibitor Perifosine in Migration and Adhesion in Multiple Myeloma (MM). (2005) (1)
- Recent developments in Paget's disease (2003) (1)
- Correction to article in Vol 86:252–258 (1999) (2000) (1)
- IL-3 Inhibits Osteoblast Formation in Multiple Myeloma Via CD45+ Cells. (2004) (1)
- Targeting p62ZIP in Marrow Stromal Cells Is Highly Effective at Inhibiting Myeloma Cell Growth and Osteoclast Formation. (2005) (1)
- Immunomodulatory Derivatives of Thalidomide (IMiD)-Induced Neutropenia Is Associated with PU.1 Downregulation and Myeloid Maturation Arrest (2008) (1)
- Model systems of osteoclast differentiation (1988) (1)
- A Potential Autocrine/Paracnne Factor in Paget's Disease of Bone (1992) (1)
- The Effect of Rapamycin, 17-AAG and the Combination on the Bone Marrow Microenvironment in Multiple Myeloma (MM). (2005) (1)
- The Role of the CXCR4 Inhibitor AMD3100 in Multiple Myeloma (MM). (2005) (1)
- disease Development of an in vivo model of human multiple myeloma bone (2011) (1)
- Osteoclast function in healthy subjects and in patients with Paget's disease (1999) (1)
- Multiple Myeloma and Other Hematological Malignancies of Bone (2010) (1)
- B447 Pomalidomide Inhibits MM Proliferation In Vitro via Enhanced Expression of Tumor Suppressor Genes (2011) (0)
- Comprar Myeloma Bone Disease | Roodman, G. David | 9781607615538 | Springer (2010) (0)
- Paget's Disease (2004) (0)
- Bone Marrow Microenvironment in Multiple Myeloma (2019) (0)
- Pagetic osteoclasts formed in vitro (1998) (0)
- Lead Authors and Contributors (2010) (0)
- Summary - Bone resorption session (2003) (0)
- SPOTLIGHT REVIEW Pathogenesis of myeloma bone disease (2008) (0)
- Role of the Chemokine Receptor CXCR4 in Waldenstrom Macroglobulinemia. (2005) (0)
- Multiple Myeloma Surveillance Counterpoint: USA (2013) (0)
- Current hypothesis for the etiology of Paget disease (1994) (0)
- Osteoclasts and myeloma cells stick together (2004) (0)
- Inhibition of Cdk4/6 by PD 0332991 Results in Abrogation of Osteoclast Formation (2008) (0)
- Mechanisms of bone metastasis. (2004) (0)
- Interleukin-3. Its biology and potential uses in pediatric hematology/oncology. (1991) (0)
- Maintaining bone health in patients with cancer (2012) (0)
- Impaired Osseous Wound Healing Following Ionizing Irradiation Is Ameliorated by Mitochondrial Targeted Nitroxide JP4-039. (2009) (0)
- Abnormal osteoclast-like cells form in Pagetic marrow cultures (1990) (0)
- Hepcidin Overproduction Mediates the Anemia of Multiple Myeloma. (2006) (0)
- Book review (2005) (0)
- Epitope mapping of recombinant human procathepsin D. (1998) (0)
- Autologous hematopoietic stem cell transplantation for poor prognosis low grade lymphoma. (1996) (0)
- microenvironment myeloma cell adhesion and growth in the bone marrow Annexin II interactions with the annexin II receptor enhance multiple (2013) (0)
- PL1.3. Developments in bone target treatment of cancer (2008) (0)
- Cancer Metastasis: Bone Complications of Myeloma and Lymphoma (2011) (0)
- List of Contributors (2020) (0)
- Developmental changes in membrane proteins from baboon erythrocytes. (1987) (0)
- Changes in the growth requirements of baboon liver hematopoietic progenitors during ontogeny. (1985) (0)
- Abstract 693: Effects of a bone-anabolic agent on metastatic bone cancer growth (2020) (0)
- Hematology-oncology. Hematology-Oncology Workgroup, Legislative Task Force on Cancer in Texas. (1987) (0)
- Effects of alendronate on cytokine production and osteoclast formation induced by human marrow stromal cells (1999) (0)
- Contributors (2012) (0)
- Nocodazole Induces Multiple Myeloma Cell Death and Reduces Tumor Growth through Sequential Microtubular Network Damage and C-Jun N-Terminal Kinase-Mediated Bcl-2 Phosphorylation. (2009) (0)
- Molecular Mechanisms Regulating Migration and Adhesion in Response to the Chemokine SDF-1 in Multiple Myeloma (MM). (2005) (0)
- Bortezomib and Osteoclasts and Osteoblasts (2011) (0)
- New anabolic approaches to treating myeloma bone disease (2011) (0)
- adherent cells from patients with the anemia of chronic disease Inhibition of erythroid colony formation by autologous bone marrow (2011) (0)
- Rutologous hematopoietic stem cell transplantation for poof prognosis low grade lymphoka (1996) (0)
- Proteomic Analysis of Post Transplant Lymphoproliferative Disorders (PTLD) Using Nanoscale Protein Microarray Techniques. (2005) (0)
- Introduction - Control of bone resorption: Six different topics related to osteoclast activity (2003) (0)
- Matrix Metalloproteinses-13 (Collagenase-3) Secreted by Multiple Myeloma Cells Enhances the Bone Resorptive Activity of Osteoclasts. (2009) (0)
- 255 – Paget's Disease of Bone (2012) (0)
- Differential Response to Proteosome Inhibition in EBV Positive and Negative Lymphoma Cell Lines: Clinical Implications in Post Transplant Lymphoproliferative Disorders (PTLD). (2005) (0)
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