Gustav E. Lienhard
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Gustav E. Lienhardbiology Degrees
Biology
#11246
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#14630
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Molecular Biology
#1720
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#1749
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Biochemistry
#1843
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#1983
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Chemistry Biology
Gustav E. Lienhard's Degrees
- PhD Biochemistry University of California, Berkeley
- Masters Molecular Biology Stanford University
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(Suggest an Edit or Addition)Gustav E. Lienhard's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Sequence and structure of a human glucose transporter. (1985) (1401)
- Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation* (2003) (959)
- Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat (1991) (825)
- A Method to Identify Serine Kinase Substrates (2002) (538)
- P 1 ,P 5 -Di(adenosine-5')pentaphosphate, a potent multisubstrate inhibitor of adenylate kinase. (1973) (450)
- AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. (2005) (431)
- Enzymatic Catalysis and Transition-State Theory (1973) (408)
- Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat. (1991) (402)
- A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family* (1997) (369)
- The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family* (1997) (360)
- Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. (2007) (353)
- Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein. (2005) (350)
- The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. (1993) (337)
- Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. (2005) (294)
- Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity. (2005) (290)
- Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes. (1992) (249)
- Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. (2000) (235)
- Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1. (2007) (195)
- Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes. (1990) (176)
- Temporal Dynamics of Tyrosine Phosphorylation in Insulin Signaling (2006) (175)
- Insulin elicits a redistribution of transferrin receptors in 3T3-L1 adipocytes through an increase in the rate constant for receptor externalization. (1987) (172)
- Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. (1993) (171)
- Possible transition-state analogs for ribonuclease. The complexes of uridine with oxovanadium(IV) ion and vanadium(V) ion. (1973) (169)
- Characterization of the Insulin-regulated Membrane Aminopeptidase in 3T3-L1 Adipocytes (*) (1996) (164)
- Monosaccharide transporter of the human erythrocyte. Characterization of an improved preparation. (1982) (162)
- Inhibition of GLUT4 Translocation by Tbc1d1, a Rab GTPase-activating Protein Abundant in Skeletal Muscle, Is Partially Relieved by AMP-activated Protein Kinase Activation* (2008) (159)
- Sortilin Is the Major 110-kDa Protein in GLUT4 Vesicles from Adipocytes* (1998) (145)
- Interleukin-9 Induces Tyrosine Phosphorylation of Insulin Receptor Substrate-1 via JAK Tyrosine Kinases (*) (1995) (139)
- Non-functional phosphorylations? (2008) (126)
- 2-phenylethaneboronic acid, a possible transition-state analog for chymotrypsin. (1971) (125)
- Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. (2002) (122)
- Dexamethasone causes translocation of glucose transporters from the plasma membrane to an intracellular site in human fibroblasts. (1987) (121)
- Rab10 in insulin-stimulated GLUT4 translocation. (2008) (121)
- Thiol addition to the carbonyl group. Equilibria and kinetics. (1966) (119)
- Mechanisms of thiamine-catalyzed reactions. Decarboxylation of 2-(1-carboxy-1-hydroxyethyl)-3,4-dimethylthiazolium chloride. (1970) (118)
- Characterization of Insulin Receptor Substrate 4 in Human Embryonic Kidney 293 Cells* (1998) (113)
- Characterization of a major protein in GLUT4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane. (1994) (112)
- R-1-Acetamido-2-phenylethaneboronic acid. A specific transition-state analog for chymotrypsin (1981) (111)
- Equilibria and kinetics of ligand binding to the human erythrocyte glucose transporter. Evidence for an alternating conformation model for transport. (1981) (110)
- Phosphorylation of the glucose transporter in vitro and in vivo by protein kinase C (1985) (109)
- Insulin-induced translocation of glucose transporters from post-Golgi compartments to the plasma membrane of 3T3-L1 adipocytes (1988) (108)
- The blood—nerve barrier is rich in glucose transporter (1988) (108)
- How cells absorb glucose. (1992) (106)
- The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase. (1993) (103)
- Transforming potential of the insulin receptor substrate 1. (1995) (99)
- The glucose transporter GluT4 and secretory carrier membrane proteins (SCAMPs) colocalize in rat adipocytes and partially segregate during insulin stimulation. (1993) (96)
- Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans (2002) (96)
- Localization of transferrin receptors and insulin-like growth factor II receptors in vesicles from 3T3-L1 adipocytes that contain intracellular glucose transporters (1989) (95)
- A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia (2009) (95)
- Insulin-stimulated Phosphorylation of the Rab GTPase-activating Protein TBC1D1 Regulates GLUT4 Translocation* (2009) (93)
- Insulin stimulates cell surface aminopeptidase activity toward vasopressin in adipocytes. (1997) (92)
- The glucose transporter in 3T3-L1 adipocytes is phosphorylated in response to phorbol ester but not in response to insulin. (1986) (90)
- Purification of the cytochalasin B binding component of the human erythrocyte monosaccharide transport system. (1979) (87)
- The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains. (1992) (84)
- Membrane Amine Oxidase Cloning and Identification as a Major Protein in the Adipocyte Plasma Membrane* (1997) (83)
- Purification and reconstitution of glucose transporter from human erythrocytes. (1989) (80)
- The monosaccharide transporter from human erythrocytes is heterogeneously glycosylated. (1979) (80)
- Insulin-stimulated translocation of the HepG2/erythrocyte-type glucose transporter expressed in 3T3-L1 adipocytes. (1989) (79)
- The binding of boronic acids to chymotrypsin. (1974) (78)
- Mechanisms of thiamine-catalyzed reactions. A kinetic analysis of the decarboxylation of pyruvate by 3,4-dimethylthiazolium ion in water and ethanol. (1970) (76)
- Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C. (1994) (75)
- Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene. (1999) (74)
- Monoclonal antibodies to the glucose transporter from human erythrocytes. Identification of the transporter as a Mr = 55,000 protein. (1985) (74)
- Insulin-stimulated GLUT4 Protein Translocation in Adipocytes Requires the Rab10 Guanine Nucleotide Exchange Factor Dennd4C* (2011) (71)
- The monosaccharide transport system of the human erythrocyte. Solubilization and characterization on the basis of cytochalasin B binding. (1978) (71)
- Insulin signalling: the role of insulin receptor substrate 1. (1994) (71)
- Transition state analogs for thiamin pyrophosphate-dependent enzymes. (1976) (68)
- Expression of a functional glucose transporter in Xenopus oocytes. (1989) (68)
- Immunological identification of an insulin-responsive glucose transporter. (1982) (66)
- The monosaccharide transporter of the human erythrocyte. Transport activity upon reconstitution. (1981) (63)
- Enzymatic catalysis and the transition state theory of reaction rates: transition state analogs. (1972) (62)
- Changes in the intrinsic fluorescence of the human erythrocyte monosaccharide transporter upon ligand binding. (1982) (62)
- The monosaccharide transport system of the human erythrocyte. Orientation upon reconstitution. (1980) (61)
- A transition state analog for lysozyme. (1972) (58)
- Trafficking kinetics of the insulin-regulated membrane aminopeptidase in 3T3-L1 adipocytes. (1997) (58)
- Photolabeling of glucose-sensitive cytochalasin B binding proteins in erythrocyte, fibroblast and adipocyte membranes. (1982) (56)
- Site-specific antibodies as probes of the topology and function of the human erythrocyte glucose transporter. (1990) (55)
- Endoglycosidase f cleaves the oligosaccharides from the glucose transporter of the human erythrocyte. (1984) (54)
- Proteins antigenically related to the human erythrocyte glucose transporter in normal and Rous sarcoma virus-transformed chicken embryo fibroblasts. (1982) (54)
- Glucose transport across plasma membranes: facilitated diffusion systems (1981) (53)
- Rapid kinetics of the glucose transporter from human erythrocytes. Detection and measurement of a half-turnover of the purified transporter. (1985) (52)
- Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes. (1989) (52)
- THE STEREOCHEMISTRY OF DECARBOXYLATION OF ISOCITRATE BY ISOCITRIC ACID DEHYDROGENASE. (1964) (52)
- Insulin Receptor Substrate 4 Associates with the Protein IRAS* (2002) (52)
- Regulation of the expression of pp160, a putative insulin receptor signal protein, by insulin, dexamethasone, and 1-methyl-3-isobutylxanthine in 3T3-L1 adipocytes. (1992) (50)
- Labeling of glucose transporters at the cell surface in 3T3-L1 adipocytes. Evidence for both translocation and a second mechanism in the insulin stimulation of transport. (1988) (50)
- Mechanism of acid-catalyzed enolization of ketones (1969) (50)
- Effect of the Activation of Phosphatidylinositol 3-Kinase by a Thiophosphotyrosine Peptide on Glucose Transport in 3T3-L1 Adipocytes (*) (1995) (49)
- THE MECHANISM OF ACTION OF 6-PHOSPHOGLUCONATE DEHYDROGENASE. (1964) (48)
- Insulin-induced translocation of glucose transporters to the plasma membrane precedes full stimulation of hexose transport. (1988) (48)
- Kinetics of the purified glucose transporter. Direct measurement of the rates of interconversion of transporter conformers. (1989) (48)
- Components of signaling pathways for insulin and insulin-like growth factor-I in muscle myoblasts and myotubes. (1992) (46)
- Translocation of the brain-type glucose transporter largely accounts for insulin stimulation of glucose transport in BC3H-1 myocytes. (1990) (46)
- Immunological identification of the human erythrocyte monosaccharide transporter. (1980) (45)
- The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning. (1993) (44)
- Isolation and characterization of the 160,000-Da phosphotyrosyl protein, a putative participant in insulin signaling. (1991) (44)
- Potent activation of phosphatidylinositol 3'-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains. (1994) (44)
- Regulation of cellular membrane transport by the exocytotic insertion and endocytic retrieval of transporters (1983) (42)
- Novel insulin-elicited phosphoproteins in adipocytes. (2005) (41)
- Increased intracellular sequestration of the insulin-regulated aminopeptidase upon differentiation of 3T3-L1 cells. (1998) (40)
- Isolation of vesicles containing insulin-responsive, intracellular glucose transporters from 3T3-L1 adipocytes. (1986) (40)
- Identification of the glucose transporter in rat skeletal muscle. (1983) (39)
- Monosaccharide transport system of the human erythrocyte. Identification of the cytochalasin B binding component. (1977) (38)
- Synip phosphorylation does not regulate insulin-stimulated GLUT4 translocation. (2005) (38)
- The role of strain in catalysis by lysozyme. (1971) (38)
- Insulin stimulates fluid-phase endocytosis and exocytosis in 3T3-L1 adipocytes. (1986) (36)
- A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b. (2015) (34)
- Calmodulin binds to the Rab GTPase activating protein required for insulin-stimulated GLUT4 translocation. (2005) (33)
- Kinetics and Mechanism of the Hydrolysis of 2-Acetyl-3,4-dimethylthiazolium Ion1 (1966) (32)
- The effect of gadolinium ion on the binding of inhibitors and substrates to lysozyme. (1974) (30)
- Chapter 23. Transition State Analogs as Enzyme Inhibitors (1972) (29)
- Impact of Genetic Background and Ablation of Insulin Receptor Substrate (IRS)-3 on IRS-2 Knock-out Mice* (2003) (29)
- The reaction of carbanions with N,S-diacetylcysteamine. A model for enzymatic carbon--carbon condensation. (1965) (27)
- Phenylarsine oxide stimulates hexose transport in 3T3-L1 adipocytes by a mechanism other than an increase in surface transporters. (1989) (26)
- Monosaccharide transport in protein-depleted vesicles from erythrocyte membranes. (1977) (25)
- Life without the IRS (1994) (25)
- Insulin receptor substrate 4 supports insulin- and interleukin 4-stimulated proliferation of hematopoietic cells. (1999) (25)
- κB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation. (2014) (25)
- Identification and partial purification of the insulin-responsive glucose transporter from 3T3-L1 adipocytes. (1986) (24)
- Association of insulin receptor substrate 3 with SH2 domain-containing proteins in rat adipocytes. (1998) (24)
- Cloning and characterization of a 22 kDa protein from rat adipocytes: a new member of the reticulon family. (1999) (23)
- Adipocytes contain a novel complex similar to the tuberous sclerosis complex. (2006) (22)
- Kinetic evidence for a (4-amino-2-methyl-5-pyrimidinyl)methyl-enzyme intermediate in the thiaminase I reaction. (1970) (21)
- Cloning and preliminary characterization of a 105 kDa protein with an N-terminal kinase-like domain. (2000) (20)
- Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes. (2009) (20)
- Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains. (1999) (19)
- The 47kDa Akt substrate associates with phosphodiesterase 3B and regulates its level in adipocytes. (2006) (18)
- Regulation of protein phosphorylation by insulin and an insulinomimetic oligosaccharide in 3T3-L1 adipocytes and Fao hepatoma cells. (1988) (18)
- Evidence against dephosphorylation of insulin-elicited phosphotyrosine proteins in vivo by the phosphatase PTP2C. (1995) (16)
- Kinetics of proton transfer from the .alpha.-carbon of ethyl thioacetate and its dimethyliminium derivative (1968) (16)
- Activation of PI 3-kinase in 3T3-L1 adipocytes by association with insulin receptor substrate-1. (1994) (15)
- The inactivation of acetylcholinesterase by trimethyloxonium ion, an active-site-directed methylating agent. (1974) (15)
- POSSIBLE TRANSITION‐STATE ANALOGS FOR RIBONUCLEASE, THE COMPLEXES OF URIDINE WITH OXOVANADIUM(IV) ION AND VANADIUM(V) ION (1974) (14)
- Rab 10 in insulin-stimulated GLUT 4 translocation (2008) (13)
- Stoichiometry of site-specific protein phosphorylation estimated with phosphopeptide-specific antibodies. (2003) (12)
- Analysis of TBC1D4 in patients with severe insulin resistance (2010) (11)
- Insulin signalling and the stimulation of glucose transport. (1994) (11)
- Characterization of vesicles containing insulin-responsive intracellular glucose transporters isolated from 3T3-L1 adipocytes by an improved procedure. (1988) (11)
- DECAMETHOXONIUM, AN ALKYLATING ANALOG OF DECAMETHONIUM (1974) (10)
- The glucose transporter in human fibroblasts is phosphorylated in response to phorbol ester but not in response to growth factors. (1987) (10)
- Association of protein kinase Cλ with adducin in 3T3-L1 adipocytes (2001) (8)
- Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes. (2001) (8)
- General Acid and General Base Catalysis by the Monoanions of Dicarboxylic Acids (1967) (6)
- Search for the addition of monodentate nucleophiles to boric and benzeneboronic acids in water (1972) (6)
- Insulin. Life without the IRS. (1994) (5)
- Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism (1993) (4)
- THE GLUCOSE TRANSPORTER OF HUMAN ERYTHROCYTES (1983) (4)
- Kinetic Demonstration of a Tetrahedral Intermediate in the Hydrolysis of Diethyl Acetylmalonate and Diethyl Acetylethylmalonate1 (1965) (4)
- [Vascularization of Keith and Flack's node (author's transl)]. (1977) (2)
- The activity of the erythrocyte monoaccharide transport system is not correlated with crosslinkage of band 3 protein. (1977) (2)
- One transporter per vesicle: determination of the basis of the insulin effect on glucose transport. (1984) (2)
- [Vascularization of the human sino-atrial node (author's transl)]. (1972) (1)
- Expression of T cell receptor gamma-chain in murine cytotoxic T cells: analysis of a highly transcribed nonrearranged gene cluster. (1988) (1)
- Anti-peptide antibodies as probes of the topology and function of the human erythrocyte glucose transporter (1989) (1)
- Increased glucose transport in response to phorbol ester growth factors, and insulin: relationship to phosphorylation of the glucose transporter (1986) (1)
- Rab‐GAP AS160 is differentially regulated by multiple effectors of glucose transport in mouse skeletal muscle (2006) (0)
- Antigenically Related to the Human Erythrocyte Glucose Transporter in Normal and Rous Sarcoma Virus-Transformed Chicken Embryo Fibroblasts (2018) (0)
- Effect of Insulin or in vitro Contraction on AS160 Phosphorylation in Rat Skeletal Muscle: 1059 3:05 PM ??? 3:20 PM (2005) (0)
- Fiber type‐specific regulation of the Akt substrate of 160 kDa (AS160) in mouse skeletal muscle (2007) (0)
- Phosphorylation state of the glucose transporter from 3T3-L1 adipocytes: effect of insulin and phorbol ester (1986) (0)
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