Graham H. Coombs

Q: What Schools Are Affiliated With Graham H. Coombs

Graham H. Coombs is affiliated with the following schools: Technical University of Denmark, University of Maryland, College Park, University of Strathclyde, Newcastle University, University of Glasgow

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Graham H. Coombs

Biology

#9415

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#12619

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Cell Biology

#401

World Rank

#411

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Biochemistry

#1436

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#1560

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Graham H. Coombs's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guidelines for the use and interpretation of assays for monitoring autophagy (2012) (6925)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs. (2003) (848)
Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis (2007) (739)
Evidence for the shikimate pathway in apicomplexan parasites (1998) (460)
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance. (2011) (388)
Proteomic Analysis of Rhoptry Organelles Reveals Many Novel Constituents for Host-Parasite Interactions in Toxoplasma gondii* (2005) (367)
Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets. (2001) (282)
Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response. (1998) (261)
Evolutionary relationships among protozoa. (1998) (253)
Cysteine peptidases as virulence factors of Leishmania. (2004) (252)
Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. (1996) (231)
Endosome Sorting and Autophagy Are Essential for Differentiation and Virulence of Leishmania major* (2006) (216)
Proline Metabolism in Procyclic Trypanosoma brucei Is Down-regulated in the Presence of Glucose* (2005) (213)
Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms (1992) (207)
Vesicular Systems (Niosomes and Liposomes) for Delivery of Sodium Stibogluconate in Experimental Murine Visceral Leishmaniasis (1988) (188)
Metabolism of Leishmania: proven and predicted. (2007) (186)
Inhibition of Lipopolysaccharide-Induced Macrophage IL-12 Production by Leishmania mexicana Amastigotes: The Role of Cysteine Peptidases and the NF-κB Signaling Pathway1 (2004) (177)
A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers (1981) (172)
Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions. (1998) (170)
Leishmania mexicana: energy metabolism of amastigotes and promastigotes. (1982) (167)
Cysteine proteinases of parasitic protozoa. (1990) (157)
Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana (2006) (152)
Autophagy in protists (2011) (151)
Clan CD cysteine peptidases of parasitic protozoa. (2003) (145)
Resistance to Pentamidine in Leishmania mexicana Involves Exclusion of the Drug from the Mitochondrion (2002) (144)
The shikimate pathway and its branches in apicomplexan parasites. (2002) (143)
Cell death in parasitic protozoa: regulated or incidental? (2012) (142)
Protein turnover and differentiation in Leishmania (2007) (141)
The use of a highly sensitive electrophoretic method to compare the proteinases of trichomonads. (1987) (137)
Targeting polyamines of parasitic protozoa in chemotherapy. (2001) (135)
Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1. (2004) (135)
A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C‐terminal extension (1989) (134)
Cysteine Protease B of Leishmania mexicana Inhibits Host Th1 Responses and Protective Immunity 1 (2003) (132)
Biochemistry of Parasitic Protozoa (1978) (132)
Recent advances in identifying and validating drug targets in trypanosomes and leishmanias. (1999) (127)
The Multiple cpb Cysteine Proteinase Genes ofLeishmania mexicana Encode Isoenzymes That Differ in Their Stage Regulation and Substrate Preferences* (1997) (126)
Combinatorial library of peptidotriazoles: identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease. (2004) (121)
Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8. (2003) (117)
Leishmania mexicana: amastigote hydrolases in unusual lysosomes. (1986) (113)
An essential role for the Leishmania major metacaspase in cell cycle progression (2008) (112)
Bloodstream form Trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes (2006) (112)
A comparative study of Leishmania mexicana amastigotes and promastigotes. Enzyme activities and subcellular locations. (1982) (111)
Enzymes of parasite thiol metabolism as drug targets. (1999) (110)
Characterization of a multi‐copy gene for a major stage‐specific cysteine proteinase of Leishmania mexicana (1992) (109)
The diversity and evolution of thioredoxin reductase: new perspectives. (2002) (108)
Ultrastructural analysis of the sporozoite of Cryptosporidium parvum. (1998) (106)
Neomonada and the origin of animals and fungi. (1998) (103)
Proteinases of Leishmania mexicana and other flagellate protozoa (1982) (101)
Effects of proteinase inhibitors on the growth and differentiation of Trypanosoma cruzi. (1994) (100)
Metabolomics to Unveil and Understand Phenotypic Diversity between Pathogen Populations (2010) (99)
Parasite proteinases and amino acid metabolism: possibilities for chemotherapeutic exploitation (1997) (98)
Characterisation of global protein expression by two-dimensional electrophoresis and mass spectrometry: proteomics of Toxoplasma gondii. (2002) (97)
Leishmania mexicana: enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals. (1985) (96)
Purification and characterization of methionine gamma-lyase from Trichomonas vaginalis. (1991) (94)
Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major (2009) (92)
The Leishmania mexicana Cysteine Protease, CPB2.8, Induces Potent Th2 Responses 1 (2003) (91)
Metacaspase 2 of Trypanosoma brucei is a calcium‐dependent cysteine peptidase active without processing (2007) (88)
Putrescine and spermidine transport in Leishmania. (2000) (88)
Trypanosomiasis and leishmaniasis : biology and control (1998) (87)
Enzymes and compartmentation of core energy metabolism of anaerobic protists - a special case in eukaryotic evolution? (1998) (86)
Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background (2012) (85)
A developmentally regulated cysteine proteinase gene of Leishmania mexicana (1992) (84)
Leishmania mexicana and Leishmania major: attenuation of wild-type parasites and vaccination with the attenuated lines. (2003) (82)
Purine and pyrimidine metabolism in parasitic protozoa. (1988) (80)
Expression of Multiple CPB Genes Encoding Cysteine Proteases Is Required for Leishmania mexicana Virulence In Vivo (2003) (80)
The Amitochondriate Eukaryote Trichomonas vaginalis Contains a Divergent Thioredoxin-linked Peroxiredoxin Antioxidant System* (2004) (78)
Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry. (2010) (78)
Three dimensional structure of the leishmania amastigote as revealed by computer-aided reconstruction from serial sections (1986) (78)
ATG5 Is Essential for ATG8-Dependent Autophagy and Mitochondrial Homeostasis in Leishmania major (2012) (78)
3-Mercaptopyruvate Sulfurtransferase of LeishmaniaContains an Unusual C-terminal Extension and Is Involved in Thioredoxin and Antioxidant Metabolism* (2003) (76)
Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation (2013) (76)
Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana. (2000) (75)
Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens 1 (2003) (74)
Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana. (1997) (74)
Evaluation of mobile phase characteristics on three zwitterionic columns in hydrophilic interaction liquid chromatography mode for liquid chromatography-high resolution mass spectrometry based untargeted metabolite profiling of Leishmania parasites. (2014) (74)
Purification and characterization of proteolytic enzymes of Leishmania mexicana mexicana amastigotes and promastigotes. (1984) (74)
Morphological Events during the Cell Cycle of Leishmania major (2011) (73)
Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host–parasite interaction (2000) (72)
Crystal structure of a Trypanosoma brucei metacaspase (2012) (72)
Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii. (1996) (70)
An analysis of the proteinases of Trichomonas vaginalis by polyacrylamide gel electrophoresis (1983) (70)
Trichomonas vaginalis, Tritrichomonas foetus, and Trichomitus batrachorum: comparative proteolytic activity. (1984) (68)
The Stage-regulated Expression of Leishmania mexicanaCPB Cysteine Proteases Is Mediated by an Intercistronic Sequence Element* (2001) (67)
Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana. (1990) (67)
A potential role for ICP, a leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite (2004) (66)
Identification and characterisation of high affinity nucleoside and nucleobase transporters in Toxoplasma gondii. (2003) (65)
Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana. (1994) (64)
The Primitive Protozoon Trichomonas vaginalisContains Two Methionine γ-Lyase Genes That Encode Members of the γ-Family of Pyridoxal 5′-Phosphate-dependent Enzymes* (1998) (64)
Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor* (2011) (63)
Two pathways for cysteine biosynthesis in Leishmania major. (2009) (62)
Processing and trafficking of cysteine proteases in Leishmania mexicana. (2000) (62)
Trifluoromethionine, a Prodrug Designed against Methionine γ-Lyase-Containing Pathogens, Has Efficacy In Vitro and In Vivo against Trichomonas vaginalis (2001) (62)
The AP3 adaptor is involved in the transport of membrane proteins to acidocalcisomes of Leishmania (2008) (62)
In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization (2016) (62)
Proteinases of Leishmania mexicana amastigotes and promastigotes: analysis by gel electrophoresis. (1981) (61)
Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis (2010) (61)
The release of hydrolases from Trichomonas vaginalis and Tritrichomonas foetus. (1988) (61)
Multiple protease activities in Giardia intestinalis trophozoites. (1995) (60)
Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii (1996) (60)
Leishmania mexicana: subcellular distribution of enzymes in amastigotes and promastigotes. (1985) (60)
Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii. (1996) (57)
Cysteine Biosynthesis in Trichomonas vaginalis Involves Cysteine Synthase Utilizing O-Phosphoserine* (2006) (57)
Recent advances in the search for new anti-coccidial drugs. (2002) (56)
Respiration of Leishmania mexicana amastigotes and promastigotes. (1981) (56)
Phosphomonoesterases of Leishmania mexicana mexicana and other flagellates. (1987) (56)
Influence of parasite encoded inhibitors of serine peptidases in early infection of macrophages with Leishmania major (2009) (55)
Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5 (2006) (55)
Chemotherapy of human leishmaniasis and trypanosomiasis. (1997) (55)
Biochemical characteristics of the metacyclic forms of Leishmania major and L. mexicana mexicana (1989) (55)
A comparative study of the proteolytic enzymes of Trypanosoma brucei, T. equiperdum, T. evansi, T. vivax, Leishmania tarentolae and Crithidia fasciculata. (1983) (52)
The potential of metabolomics for Leishmania research in the post-genomics era (2010) (50)
Oligopeptidase B deficient mutants of Leishmania major. (2011) (50)
Phosphoenolpyruvate Carboxylase Identified as a Key Enzyme in Erythrocytic Plasmodium falciparum Carbon Metabolism (2014) (49)
The Structure of Leishmania mexicana ICP Provides Evidence for Convergent Evolution of Cysteine Peptidase Inhibitors* (2006) (48)
The specificity of trichomonad cysteine proteinases analysed using fluorogenic substrates and specific inhibitors. (1990) (48)
Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells (2012) (48)
Inhibition of Leishmania amastigote growth by antipain and leupeptin. (1984) (46)
Transformation in vitro of Leishmania mexicana amastigotes to promastigotes: nutritional requirements and the effect of drugs (1981) (46)
The Mercaptopyruvate Sulfurtransferase of Trichomonas vaginalis Links Cysteine Catabolism to the Production of Thioredoxin Persulfide (2009) (45)
Identification and molecular cloning of four cysteine proteinase genes from the pathogenic protozoon Trichomonas vaginalis. (1994) (43)
Metabolic Variation during Development in Culture of Leishmania donovani Promastigotes (2011) (42)
Isolation of lmcpc, a gene encoding a Leishmania mexicana cathepsin-B-like cysteine proteinase. (1995) (41)
Leishmania mexicana: purine-metabolizing enzymes of amastigotes and promastigotes. (1985) (41)
Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism (2015) (40)
Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays. (2006) (40)
Folate utilisation by Leishmania species and the identification of intracellular derivatives and folate-metabolising enzymes. (1987) (39)
Identification of Semicarbazones, Thiosemicarbazones and Triazine Nitriles as Inhibitors of Leishmania mexicana Cysteine Protease CPB (2013) (39)
Processing and trafficking of Leishmania mexicana GP63. Analysis using GP18 mutants deficient in glycosylphosphatidylinositol protein anchoring. (2002) (39)
Biochemical peculiarities and drug targets in Cryptosporidium parvum: lessons from other coccidian parasites. (1999) (39)
The SNARE protein family of Leishmania major (2006) (39)
Parasite cysteine proteinases (1996) (39)
Vaccination with a preparation based on recombinant cysteine peptidases and canine IL-12 does not protect dogs from infection with Leishmania infantum. (2006) (38)
Cystatin-like cysteine proteinase inhibitors of parasitic protozoa. (1992) (38)
Role of the Trypanosoma brucei natural cysteine peptidase inhibitor ICP in differentiation and virulence (2007) (38)
Stage-specific proteinases of Leishmania mexicana mexicana promastigotes. (1992) (37)
Analysis of the proteinases of Trypanosoma brucei. (1990) (37)
The Substrate Specificity of a Recombinant Cysteine Protease from Leishmania mexicana: Application of a Combinatorial Peptide Library Approach (2000) (37)
Leishmania panamensis: comparative inhibition of nuclear DNA topoisomerase II enzymes from promastigotes and human macrophages reveals anti-parasite selectivity of fluoroquinolones, flavonoids and pentamidine. (2007) (37)
The Crystal Structure of Leishmania major 3-Mercaptopyruvate Sulfurtransferase (2003) (37)
Multiple cysteine proteinases of the pathogenic protozoon Tritrichomonas foetus: identification of seven diverse and differentially expressed genes. (1995) (36)
Glycosome turnover in Leishmania major is mediated by autophagy (2014) (36)
The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection. (2012) (36)
Effects of methotrexate and other antifolates on the growth and dihydrofolate reductase activity of Leishmania promastigotes. (1987) (36)
Cathepsin B-like cysteine proteases of Leishmania mexicana. (1993) (36)
Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation (2012) (35)
A comparative study of the purine- and pyrimidine-metabolising enzymes of a range of trypanosomatids. (1986) (35)
Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array. (1994) (35)
Alterations in the biochemistry and ultrastructure of the deep abdominal flexor muscle of the norway lobster Nephrops norvegicus during infection by a parasitic dinoflagellate of the genus Hematodinium. (2000) (35)
Proteinase inhibitors as antileishmanial agents. (1982) (35)
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
Soluble GPI8 restores glycosylphosphatidylinositol anchoring in a trypanosome cell-free system depleted of lumenal endoplasmic reticulum proteins. (2000) (33)
Molecular detection of Hematodinium spp. in Norway lobster Nephrops norvegicus and other crustaceans. (2006) (33)
Biochemistry of the coccidia. (1997) (33)
Proteinases of trypanosomes and Leishmania. (1997) (33)
Leishmania mexicana: drug sensitivities of promastigotes and transforming amastigotes. (1983) (32)
Analysis of Leishmania proteinases reveals developmental changes in species-specific forms and a common 68-kDa activity (1987) (32)
Amino acid consumption by the parasitic, amoeboid protists Entamoeba histolytica and E. invadens. (1995) (31)
Cysteine or serine proteinase? (1989) (31)
Distinct Roles in Autophagy and Importance in Infectivity of the Two ATG4 Cysteine Peptidases of Leishmania major* (2012) (29)
Changes in the plasma free amino acid profile of the Norway lobster Nephrops norvegicus at different stages of infection by a parasitic dinoflagellate (genus Hematodinium) (1999) (29)
Biochemistry and Molecular Biology of Anaerobic Protozoa (1989) (29)
Overexpression of the Natural Inhibitor of Cysteine Peptidases in Leishmania mexicana Leads to Reduced Virulence and a Th1 Response (2009) (28)
Proteinase activity in rumen ciliate protozoa. (1988) (28)
The influence of defined ante-mortem stressors on the early post-mortem biochemical processes in the abdominal muscle of the Norway lobster, Nephrops norvegicus (Linnaeus, 1758) (2010) (27)
Development and application of an immunoassay diagnostic technique for studying Hematodinium infections in Nephrops norvegicus populations. (2001) (27)
Purification of cysteine proteinases from trichomonads using bacitracin-Sepharose. (1993) (27)
Energy Metabolism in Anaerobic Protozoa (1995) (26)
Carboxydipeptidase activities of recombinant cysteine peptidases. Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana. (2004) (26)
α‐Ketoheterocycles as Inhibitors of Leishmania mexicana Cysteine Protease CPB (2010) (26)
Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation (2012) (26)
Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B. (2002) (26)
L-methionine catabolism in trichomonads. (1987) (25)
Interaction of leishmania metacyclics with macrophages. (1989) (25)
Detection of the parasitic dinoflagellate Hematodinium in the Norway lobster Nephrops norvegicus by ELISA. (2002) (25)
Expression of Cysteine Proteinases by Metacyclic Promastigotes of Leishmania mexicana (1994) (25)
The expression sites for variant surface glycoproteins of Trypanosoma brucei. (1997) (25)
Design and evaluation of Trypanosoma brucei metacaspase inhibitors. (2010) (24)
Polyamine biosynthesis in trichomonads. (1986) (24)
Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes. (2004) (23)
Analysis of the S(2) subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids. (2001) (23)
The phylum Apicomplexa: an update on the molecular phylogeny. (1998) (23)
Landmarks in trypanosome research. (1997) (23)
Differentiation of Leishmania major is impaired by over-expression of pyroglutamyl peptidase I. (2006) (23)
Dipeptidyl α-fluorovinyl Michael acceptors: Synthesis and activity against cysteine proteases (2007) (23)
The role of conserved residues of chagasin in the inhibition of cysteine peptidases (2008) (22)
Current public health status of the trypanosomiases and leishmaniases. (1997) (22)
Effect of capture method on the physiology and nucleotide breakdown products in the Norway lobster (Nephrops norvegicus) (2009) (22)
Structures of Leishmania major orthologues of macrophage migration inhibitory factor. (2009) (22)
Growth in vitro and metabolism of Plasmodium vinckei chabaudi. (1975) (22)
A parasitic scuticociliate infection in the Norway lobster (Nephrops norvegicus). (2005) (22)
S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids. (2001) (21)
Squamous cell carcinoma antigen 1 is an inhibitor of parasite‐derived cysteine proteases (2007) (21)
Purification of particulate malate dehydrogenase and phosphoenolpyruvate carboxykinase from Leishmania mexicana mexicana. (1985) (21)
Classification of protozoa and protists: the current status. (1998) (21)
Combinatorial library of peptide isosters based on Diels-Alder reactions: identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana. (2001) (21)
The biology of antigenic variation in African trypanosomes. (1997) (21)
Purine-metabolising enzymes in Entamoeba histolytica. (1986) (20)
Generation of Leishmania mutants lacking antibiotic resistance genes using a versatile hit-and-run targeting strategy. (2004) (20)
The use of a new viability assay to determine the susceptibility of Cryptosporidium and Eimeria sporozoites to respiratory inhibitors and extremes of pH. (1996) (20)
Tracking autophagy during proliferation and differentiation of Trypanosoma brucei (2014) (20)
The in-vitro activity of metronidazole against strains of Escherichia coli with impaired DNA repair systems. (1984) (20)
The effects of carbon dioxide and oxygen upon the growth and in vitro transformation of Leishmania mexicana mexicana. (1981) (20)
Use of inhibitors to identify essential cysteine proteinases of Trichomonas vaginalis. (1997) (20)
Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana. (2001) (19)
Differential inhibition of high and low Mr thioredoxin reductases of parasites by organotelluriums supports the concept that low Mr thioredoxin reductases are good drug targets (2008) (19)
Stable transformation of trypanosomatids through targeted chromosomal integration of the selectable marker gene encoding blasticidin S deaminase. (2000) (19)
Orotate phosphoribosyltransferase and orotidine‐5′‐phosphate decarboxylase in two parasitic kinetoplastid flagellates (1980) (19)
Subcellular localisation of purine-metabolising enzymes in Leishmania mexicana mexicana. (1985) (19)
Trichomonas species: homocysteine desulphurase and serine sulphydrase activities. (1987) (19)
Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana. (2001) (19)
Amine production by Leishmania mexicana. (1985) (18)
Differences in enzyme activities between two species of Hematodinium, parasitic dinoflagellates of crustaceans. (2007) (17)
Eimeria tenella contains a pyrophosphate-dependent phosphofructokinase and a pyruvate kinase with unusual allosteric regulators. (1994) (17)
The pathway of secretion of proteinases in Trichomonas vaginalis. (1995) (17)
Structure of Leishmania major cysteine synthase (2012) (17)
Genomic and Metabolomic Polymorphism among Experimentally Selected Paromomycin-Resistant Leishmania donovani Strains (2019) (17)
Dihydroorotate dehydrogenase, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase in Plasmodium falciparum. (1981) (16)
Identification and partial characterisation of metalloproteases secreted by a Mesanophrys-like ciliate parasite of the Norway lobster Nephrops norvegicus. (2005) (16)
Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis. (2008) (16)
Heparin Modulates the Endopeptidase Activity of Leishmania mexicana Cysteine Protease Cathepsin L-Like rCPB2.8 (2013) (16)
Antitrichomonal activity of α-difluoromethylornithine (1987) (16)
Revolution among the protozoa. (1998) (16)
Uptake of amino acids by the parasitic, flagellated protist Trichomonas vaginalis. (1995) (16)
Future prospects in chemotherapy for trypanosomiasis. (2004) (16)
Metronidazole resistant trichomonads: mechanisms of in vitro developed anaerobic resistance. (1989) (15)
Cysteine proteinases of leishmanias (1991) (15)
Conservation of cation-transporting ATPase genes in Leishmania. (1991) (15)
Characterization of Leishmania infantum thiol‐dependent reductase 1 and evaluation of its potential to induce immune protection (2012) (15)
Molecular phylogeny of kinetoplastids. (1998) (15)
Polyamine metabolism in trypanosomes. (1997) (15)
PFPI-like genes are expressed in Leishmania major but are pseudogenes in other Leishmania species. (2006) (14)
The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes. (1998) (14)
Changes in hepatic xenobiotic-metabolising enzymes in mouse liver following infection with Leishmania donovani. (1990) (14)
Metabolomic profiling and stable isotope labelling of Trichomonas vaginalis and Tritrichomonas foetus reveal major differences in amino acid metabolism including the production of 2-hydroxyisocaproic acid, cystathionine and S-methylcysteine (2017) (14)
Relationships between lower fungi and protozoa. (1998) (13)
Protozoal contribution to ruminal oxygen utilization. (1989) (13)
Quality changes in chilled Norway lobster (Nephrops norvegicus) tail meat and the effects of delayed icing (2011) (13)
S-Adenosylhomocysteine hydrolase activity in Trichomonas vaginalis and other trichomonads. (1985) (13)
Protein phosphorylation and protein kinases in trypanosomatids. (1997) (12)
The time course of early post-mortem biochemical processes in the abdominal muscle of a commercially important decapod crustacean (Nephrops norvegicus): implications for post-catch processing (2008) (12)
Molecular and cellular evolution of ciliates: a phylogenetic perspective (1998) (12)
Control strategies for African trypanosomiases: their sustainability and effectiveness. (1997) (12)
Trichomonas vaginalis: amoeboid and flagellated forms synthesize similar proteinases. (1995) (12)
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast* (2016) (11)
Oxygen and aerotolerant protozoa: studies using non-invasive techniques. (1989) (11)
Identification of Lead Compounds Targeting the Cathepsin B-Like Enzyme of Eimeria tenella (2011) (11)
Cell signalling in trypanosomatids. (1997) (11)
Drug resistance in trypanosomatids. (1997) (11)
Specific negative charges in cysteine protease isoforms of Leishmaniamexicana are highly influential on the substrate binding and hydrolysis. (2005) (11)
Phylogenetics of protozoan tubulin with reference to the amitochondriate eukaryotes. (1998) (10)
Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome* (2016) (10)
Aerotolerantly anaerobic protozoa: some unsolved problems. (1989) (10)
Sterol metabolism of Leishmania and trypanosomes; potential for chemotherapeutic exploitation. (1997) (10)
Biochemical and genetic evidence for a family of heterotrimeric G-proteins in Trichomonas vaginalis. (2003) (10)
The surface membrane ofLeishmania mexicana mexicana: Comparison of amastigote and promastigote using freeze-fracture cytochemistry (2004) (10)
The catabolism of amino acids by Trichomonas vaginalis. (1989) (10)
The Products and Pathways of Glucose Catabolism in Herpetomonas muscarum ingenoplastis and Herpetomonas muscarum muscarum (1997) (9)
Protozoan paradigms for cell biology. (1999) (9)
Reply: Shikimate pathway in apicomplexan parasites (1999) (9)
Mechanistic studies on the enzymatic processing of fluorinated methionine analogues by Trichomonas vaginalis methionine γ-lyase. (2011) (9)
Comparative study of ferredoxin-linked and oxygen-metabolizing enzymes of trichomonads. (1987) (8)
Purine-metabolizing enzymes in Babesia divergens (2004) (8)
Processing and Trafficking of Leishmania mexicanaGP63 (2002) (8)
The effects of inhibitors of sulphur-containing amino acid metabolism on the growth of Trichomonas vaginalis in vitro. (1987) (8)
S-Adenosylmethionine and transmethylation reactions in trichomonads (2004) (8)
Hydrogenosomes and plastid-like organelles in amoeboflagellates, chytrids, and apicomplexan parasites. (1998) (7)
The molecular epidemiology of trypanosomatids. (1997) (7)
The oxidative response of rabbit peritoneal neutrophils to leishmanias and other trypanosomatids. (1989) (7)
Erratum: Evidence for the shikimate pathway in apicomplexan parasites (1998) (7)
Pyrimidine biosynthetic enzymes in Babesia hylomysci. (1982) (7)
Flagyl and reduced nicotinamide adenine dinucleotide (1974) (7)
Leishmania mexicana: conversion of dihydroorotate to orotate in amastigotes and promastigotes. (1982) (7)
Molecular cloning and localization of a calpain-like protease from the abdominal muscle of Norway lobster Nephrops norvegicus (2010) (6)
Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes (2021) (6)
Hydrolysis of L-leucine methyl ester by Leishmania mexicana mexicana amastigote cysteine proteinases. (1992) (6)
Antileishmanial Activity of L-Leucine Methyl Ester and L-Tryptophanamide (1989) (6)
Sequencing and mapping the African trypanosome genome. (1997) (6)
The structure and biosynthesis of trypanosomatid glycosylphosphatidylinositols. (1997) (6)
Purine phosphoribosyltransferases of Leishmania mexicana mexicana and other flagellate protozoa. (1985) (6)
Phylogenetic relationships of the Myxozoa. (1998) (6)
Antileishmanial activity of a novel 2,4-diaminopyrimidine (1987) (5)
Synthesis and antitrichomonal activity of azinium (azolium) 4-nitrobenzimidazolate betaines and their derivatives (1992) (5)
Glycolysis of Kinetoplastida. (1997) (5)
Current trends in parasite vector interactions. (1997) (5)
Intermediary metabolism in parasitic protozoa. (1987) (5)
Respiratory activity in Giardia spp. (1989) (5)
In-vitro antiamoebic activity of some plants used in traditional medicine. (1989) (5)
Inhibitor of Cysteine Peptidase Does Not Influence the Development of Leishmania mexicana in Lutzomyia longipalpis (2009) (5)
Antitrichomonal activity of compounds that affect DNA and its repair. (1983) (4)
Generation of Megasomes During the Promastigote — Amastigote Transformation of Leishmania Mexicana Mexicana in Vitro (1989) (4)
Phosphomonoesterases and Proteinases of Leishmanias (1987) (4)
Nucleic Acid Metabolism (1977) (4)
Organelle and enzyme evolution in trypanosomatids. (1998) (4)
Evolutionary relationships between protist phyla constructed from LSUrRNAs accounting for unequal rates of substitution among sites. (1998) (4)
Plastid-like DNA in apicomplexans. (1998) (3)
Biochemical Mechanisms of Drug Action (1977) (3)
Proteinases of anaerobic protozoa: trichomonads and rumen ciliates. (1989) (3)
Relationships between amoeboflagellates. (1998) (3)
The antagonistic effects of acetate and lactate upon the trichomonacidal activity of metronidazole. (1983) (3)
Electrophoretic analysis of the polypeptides of Leishmania amastigotes and promastigotes. (1986) (3)
Basic Research on Malaria. (1974) (3)
Is the multidrug resistant protein of the malaria parasite involved in drug resistance (1991) (3)
Differentiation between Giardia lamblia and Giardia muris by Southern blot analysis and orthogonal-field-alternation gel electrophoresis karyotype analysis. (1989) (3)
Trichomonads Parasitic in Humans, B.M. Honigberg (Ed.). Springer Verlag, New York (1989), 424 + x pp., 258,— DM. ISBN 0-387-96903-9 (1991) (3)
Evolutionary relationships of Microsporidia. (1998) (3)
High-resolution structure of recombinant Trichomonas vaginalis thioredoxin. (2006) (3)
Evolutionary genetics of Trypanosoma, Leishmania and other organisms: epidemiological, taxonomical and medical implications. (1997) (3)
Purification of hydrogenosomal enzymes from Tritrichomonas fetus. (1989) (2)
Purine salvage by Acanthamoeba castellanii. (1987) (2)
The flagyl analogue of nicotinamide adenine dinucleotide (1974) (2)
Molecular systematics of the intestinal amoebae. (1998) (2)
Antitrichomonal activity of alpha-difluoromethylornithine. (1987) (2)
Purification and characterization of proteinases of the parasitic protozoan Trichomonas vaginalis (1985) (2)
Leishmania cysteine proteinases: virulence factors in quest of a function-reply. (1998) (2)
Catabolism and the Generation of Energy. I Stages Parasitic in Vertebrates (1977) (2)
Molecular phylogeny of Trichomonas and Naegleria: implications for the relative timing of the mitochondrion endosymbiosis. (1998) (2)
Analysis of the cysteine proteinases of Leishmania mexicana and Trypanosoma cruzi using specific antisera. (1994) (2)
Preface; Current research into the biology and control of trypanosomiasis and leishmaniasis. (1997) (2)
Synthesis and Antitrichomonal Activity of Azinium (Azolium) 4- Nitrobenzimidazolate Betaines and Their Derivatives. (1992) (2)
The population dynamics and control of zoonotic visceral leishmaniasis. (1997) (2)
Acid hydrolase secretion by trichomonads. (1989) (2)
Molecular parasitology: by John E. Hyde, Open University Press, 1990. £ 18.99 (x + 302 pages) ISBN 0 335 15889 7 (1991) (1)
Proteinases of Giardia. (1989) (1)
Biochemical Protozoology As A Basis For Drug Design (1991) (1)
Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases. (2007) (1)
METHIONINE GAMMA-LYASE (MGL) FROM TRICHOMONAS VAGINALIS IN COMPLEX WITH PROPARGYLGLYCINE (2001) (1)
Leishmania CPA, CPB and CPC cysteine proteases (2013) (1)
Effects of trypanosomiasis on reproduction in domestic ruminants. (1997) (1)
DNA and protein methyltransferase activities in Trichomonas vaginalis. (1989) (1)
Leishmania major cysteine synthase (2012) (1)
The socio-economic impact of African trypanosomiasis. (1997) (1)
Emerging therapeutic targets in parasitic protozoa (1998) (1)
Evolutionary relationships among the African trypanosomes: implications for the epidemiology and generation of human sleeping sickness epidemics. (1998) (1)
Proteolysis in Leishmania: Species Differences and Developmental Changes in Proteinase Activity (1989) (1)
Strategies for the Design of New Antileishmanial Drugs (1989) (1)
Erratum to: Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis (2011) (1)
Summary Bloodstream form Trypanosoma brucei depend upon multiple metacaspases associated with RAB 11-positive endosomes (0)
Signaling Pathway B κ of Cysteine Peptidases and the NF-Amastigotes : The Role Leishmania mexicana Macrophage IL-12 Production by Inhibition of Lipopolysaccharide-Induced (2004) (0)
Investigation of the Reasons for the Susceptibility of Schizogony as a Target for Chemotherapeutic Attack in Malaria Parasites. (1973) (0)
Trichomonas vaginalis against VivoPathogens , Has Efficacy In Vitro and In-Lyase-Containing γ against Methionine Trifluoromethionine , a Prodrug Designed (2001) (0)
METHIONINE GAMMA-LYASE (MGL) FROM TRICHOMONAS VAGINALIS (2001) (0)
Studies on the CPA cysteine peptidase in the genome strain JPCM5-5 (2011) (0)
Effect of lysosomotropic agents on the survival of Leishmania donovani and L. mexicana mexicana within macrophages (1991) (0)
Mass Spectrometry based Untargeted Metabolite profiling of 3 Leishmania Parasites (2015) (0)
Characterization of hydroxymethylnitrofurazone compounds as inhibitors of Leishmania mexicana cysteine proteases (2013) (0)
Proceedings: Ultrastructural investigation of Plasmodium chabaudi: schizogony and the effect of pyrimethamine. (1974) (0)
Introduction to Parasitic Protozoa (1977) (0)
Studies on the pyrimidine biosynthetic enzymes dihydroorotate dehydrogenase, orotate phosphoribosyl-transferase and orotidine 5'-phosphate decarboxylase in a range of parasitic protozoa. (1980) (0)
Present Position and Future Prospects (1977) (0)
ULTRASTRUCTURAL INVESTIGATION OF PLASMODIUM-CHABAUDI - SCHIZOGONY AND EFFECT OF PYRIMETHAMINE (1974) (0)
ShawLongchampDowningImamuraEtAl2016-MolMicrobiol-SuppInfo (2016) (0)
The structure of metacaspase 2 from T. brucei determined in the presence of Samarium (2012) (0)
A genetic analysis of the biosynthetic pathway of the Leishmania virulence factor LPG. (1997) (0)
THE STRUCTURE OF METACASPASE 2 FROM T. BRUCEI DETERMINED IN THE PRESENCE OF CALCIUM CHLORIDE (2012) (0)
Identification and molecular cloning of four cysteine proteinase genes from the pathogenic protozoon Trichornonas vaginalis (2008) (0)
Preface. Antiparasite chemotherapy: is there hope for the future? (1997) (0)
Workshop 1N: Biochemistry of the protozoa (1987) (0)
New perspectives on protozoa (1991) (0)
Catabolism and the Generation of Energy. II Stages outside the Vertebrate Host (1977) (0)
Molecular Genetics of Parasitic Protozoa, M.J. Turner, D. Arnott (Eds.). Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (1988), 170 pp., $ 25,-, ISBN: 0-87969-313-4 (1990) (0)
Homocysteine and analysis for desulfurase homocisteina from protozoan Trichomonas viginalis. (1997) (0)
Inhibition of high Mr and low Mr thioredoxin reductases from Plasmodium falciparum and Trichomonas vaginalis by organotellurides (2008) (0)
Leishmania TDR1 - a unique trimeric glutathione transferase (2012) (0)
Hydrogenosomal ATP:AMP phosphotransferase (adenylate kinase) of Tritrichomonas fetus. (1989) (0)
Leishmaniasis: edited by K. P. Chang and R.S. Bray Elsevier B.V., Amsterdam, 1986. DFL 310 (508 pages) ISBN 0444 80683 0 (1986) (0)
Columns in HILIC mode for Liquid Chromatography-High Resolution (2018) (0)
Lipoic acid biosynthesis is essential for Plasmodium falciparum transmission and influences redox response and carbon metabolism of parasite asexual blood stages (2020) (0)
a Th 1 Response Attenuated Virulence for Mice and Potentiate Proteinase-Deficient Mutants Have Cysteine Leishmania mexicana Mottram (1998) (0)
Carrier Mediated Therapy of Murine Visceral Leishmaniasis (1989) (0)
Lack of efficacy of tubercidine and nitrobenzylthioinosine against leishmania in pertioneal exudate cells and in mice (1991) (0)
Chemical Shift Assignments of Leishmania mexicana ICP, a Novel Cysteine Peptidase Inhibitor (2006) (0)
A combinatorial approach to the identification of cysteine protease substrates and inhibitors by application of a solid-phase fluorescence quenching assay (2002) (0)
Preliminary search for chromosome-sized DNA of Entamoeba histolytica by orthogonal pulse field gradient electrophoresis. (1989) (0)
Leishmania mexicana ICP (2005) (0)
ShawLongchampDowningImamuraEtAl2016-MolMicrobiol-SuppTableS10 (2016) (0)
B Signaling Pathway κ Peptidases and the NF- Amastigotes: The Role of Cysteine mexicana Leishmania Macrophage IL-12 Production by Inhibition of Lipopolysaccharide-Induced (2011) (0)
The effects of reducing agents on the metabolism and morphology of Trichomonas vaginalis C1 NIH. (1989) (0)
Immunity Inhibits Host Th1 Responses and Protective Leishmania mexicana Cysteine Protease B of (2003) (0)
Explorer Overexpression of the Natural Inhibitor of Cysteine Peptidases in Leishmania mexicana Leads to Reduced Virulence and a Th 1 Response (2017) (0)
Invertosomes in the rumen holotrich ciliate, Isotricha prostoma. (1989) (0)
Control of Diseases caused by Parasitic Protozoa (1977) (0)
Molecular Biology and Biochemistry: An Overview (1989) (0)
The structural basis for metacaspase substrate specificity and activation (2012) (0)
THE STRUCTURE OF METACASPASE 2 (C213A MUTANT) FROM T. BRUCEI (2012) (0)
κ Peptidases and the NF- mexicana Amastigotes: The Role of Cysteine Leishmania Macrophage IL-12 Production by Inhibition of Lipopolysaccharide-Induced (2013) (0)
Insights into the metabolomes of parasites (2010) (0)

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