Gerard H. De Haas
#148,285
Most Influential Person Now
Gerard H. De Haas's AcademicInfluence.com Rankings
Gerard H. De Haasbiology Degrees
Biology
#10903
World Rank
#14265
Historical Rank
Molecular Biology
#1630
World Rank
#1658
Historical Rank
Biochemistry
#1763
World Rank
#1899
Historical Rank
Download Badge
Chemistry Biology
Gerard H. De Haas's Degrees
- PhD Biochemistry University of Amsterdam
- Masters Chemistry University of Amsterdam
- Bachelors Chemistry University of Amsterdam
Why Is Gerard H. De Haas Influential?
(Suggest an Edit or Addition)Gerard H. De Haas's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Purification and properties of phospholipase A from porcine pancreas. (1968) (486)
- Action of phospholipase A at interfaces. (1973) (436)
- Histidine at the active site of phospholipase A2. (1974) (406)
- Enzyme reactions in a membrane model. 1. A new technique to study enzyme reactions in monolayers. (1973) (310)
- Methylation of histidine-48 in pancreatic phospholipase A2. Role of histidine and calcium ion in the catalytic mechanism. (1980) (261)
- Studies on phospholipase A and its zymogen from porcine pancreas. 3. Action of the enzyme on short-chain lecithins. (1970) (249)
- Zymogen-catalyzed hydrolysis of monomeric substrates and the presence of a recognition site for lipid-water interfaces in phospholipase A2. (1974) (238)
- Purification from porcine pancreas of two molecular species with lipase activity. (1969) (206)
- Phospholipase A2 (phosphatide acylhydrolase, EC 3.1.1.4) from porcine pancreas. (1974) (203)
- The interaction of phospholipase A2 with micellar interfaces. The role of the N-terminal region. (1975) (189)
- Studies on phospholipase A and its zymogen from porcine pancreas. IV. The influence of chemical modification of the lecithin structure on substrate properties. (1972) (170)
- Purification and properties of an anionic zymogen of phospholipase A from porcine pancreas. (1968) (158)
- Structural basis of the chiral selectivity of Pseudomonas cepacia lipase. (1998) (141)
- Correlation of enzymatic activity and anticoagulant properties of phospholipase A2. (1980) (137)
- Purification and substrate specificity of Staphylococcus hyicus lipase. (1989) (132)
- Interaction of phospholipase A2 and phospholipid bilayers. (1982) (128)
- Positional specific hydrolysis of phospholipids by pancreatic lipase. (1965) (126)
- Origin of the latency phase during the action of phospholipase A2 on unmodified phosphatidylcholine vesicles. (1982) (118)
- The primary structure of bovine pancreatic phospholipase A2. (1978) (108)
- Studies on phospholipase A and its zymogen from porcine pancreas. I. The complete amino acid sequence. (1970) (106)
- The role of Asp‐49 and other conserved amino acids in phospholipases A2 and their importance for enzymatic activity (1989) (105)
- Regulation of phospholipase A2 activity by the lipid-water interface: a monolayer approach. (1979) (102)
- Kinetic analysis of the hydrolysis of lecithin monolayers by phospholipase A. (1971) (96)
- Hydrolysis of synthetic mixed-acid phosphatides by phospholipase A from human pancreas. (1963) (91)
- Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop. (1989) (89)
- Comparative studies of lipase and phospholipase A2 acting on substrate monolayers. (1976) (89)
- Cutinase from Fusarium solani pisi hydrolyzing triglyceride analogues. Effect of acyl chain length and position in the substrate molecule on activity and enantioselectivity. (1995) (86)
- Structure and thermotropic properties of 1,3-dipalmitoyl-glycero-2-phosphocholine. (1983) (86)
- The primary structure of phospholipase A2 from porcine pancreas. A reinvestigation. (1977) (85)
- Crystal structure of cutinase covalently inhibited by a triglyceride analogue (1997) (79)
- Studies on cardiolipin. 3. Structural identity of ox-heart cardiolipin and synthetic diphosphatidyl glycerol. (1966) (79)
- The complete primary structure of phospholipase A2 from human pancreas. (1983) (78)
- Lipid specificity of beta-hydroxybutyrate dehydrogenase activation. (1975) (78)
- Specific transformations at the N-terminal region of phospholipase A2. (1975) (77)
- Modification of carboxylate groups in bovine pancreatic phospholipase A2. Identification of aspartate-49 as Ca2+-binding ligand. (1981) (76)
- Competitive inhibition of lipolytic enzymes. I. A kinetic model applicable to water-insoluble competitive inhibitors. (1990) (75)
- On the positional specificity of phospholipase A from pancreas. (1965) (71)
- Role of the N-terminus in the interaction of pancreatic phospholipase A2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase A2. (1983) (70)
- Physicochemical studies on the interaction of pancreatic phospholipase A2 with a micellar substrate analogue. (1981) (68)
- The role of aspartic acid-49 in the active site of phospholipase A2. A site-specific mutagenesis study of porcine pancreatic phospholipase A2 and the rationale of the enzymatic activity of [lysine49]phospholipase A2 from Agkistrodon piscivorus piscivorus' venom. (1988) (62)
- Stereoselectivity of lipases. I. Hydrolysis of enantiomeric glyceride analogues by gastric and pancreatic lipases, a kinetic study using the monomolecular film technique. (1990) (62)
- Phosphonate analogues of triacylglycerols are potent inhibitors of lipase. (1995) (62)
- Expression of porcine pancreatic phospholipase A2. Generation of active enzyme by sequence-specific cleavage of a hybrid protein from Escherichia coli. (1987) (59)
- Zymogen-enzyme transformations. On the mechanism of activation of prophospholipase A. (1972) (59)
- Isolation and properties of prophospholipase A2 and phospholipase A2 from horse pancreas and horse pancreatic juice. (1977) (57)
- Structure of 1-acyl lysophosphatidylcholine and fatty acid complex in bilayers. (1981) (53)
- Ca2+ binding to porcine pancreatic phospholipase A2 and its function in enzyme-lipid interaction. (1978) (52)
- Amino acid sequence of phospholipase A2 from horse pancreas. (1977) (52)
- Chemical synthesis of some lecithin analogues potential inhibitors of phospholipase A. (1972) (50)
- Mechanism of action of milk lipoprotein lipase at substrate interfaces: effects of apolipoproteins. (1980) (50)
- Conformational changes in phospholipase A2 upon binding to micellar interfaces in the absence and presence of competitive inhibitors. A 1H and 15N NMR study. (1992) (49)
- On the specificity of phospholipase A. (1960) (49)
- Activation of phospholipase A2 by freshly added lysophospholipids. (1983) (48)
- Complex photophysics of the single tryptophan of porcine pancreatic phospholipase A2, its zymogen, and an enzyme/micelle complex. (1985) (48)
- Competitive inhibition of lipolytic enzymes. IV. Structural details of acylamino phospholipid analogues important for the potent inhibitory effects on pancreatic phospholipase A2. (1990) (48)
- Studies on phospholipase A and its zymogen from porcine pancreas. II. The assignment of the position of the six disulfide bridges. (1970) (47)
- Kinetic characterization of Escherichia coli outer membrane phospholipase A using mixed detergent-lipid micelles. (1989) (46)
- The site of action of phosphatide acyl-hydrolase (phospholipase A) on mixed-acid phosphatides containing a poly-unsaturated fatty acid. (1962) (46)
- Structure and function of phospholipase A2. (1981) (46)
- Simplified pathways for the preparation of some well-defined phosphoglycerides. (1973) (42)
- Competitive inhibition of lipolytic enzymes. III. Some acylamino analogues of phospholipids are potent competitive inhibitors of porcine pancreatic phospholipase A2. (1990) (42)
- Activation of porcine pancreatic phospholipase A2 by the presence of negative charges at the lipid-water interface. (1986) (42)
- Synthetic peptide from lipocortin I has no phospholipase A2 inhibitory activity (1989) (42)
- Chemical modification of the alpha-amino group in snake venom phospholipases A2. A comparison of the interaction of pancreatic and venom phospholipases with lipid--water interfaces. (1981) (40)
- Insight into the conformational dynamics of specific regions of porcine pancreatic phospholipase A2 from a time-resolved fluorescence study of a genetically inserted single tryptophan residue. (1991) (39)
- Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region. (1982) (39)
- Aggregation of porcine pancreatic phospholipase A2 and Its zymogen induced by submicellar concentrations of negatively charged detergents. (1983) (37)
- Semisynthesis of phospholipase A2. Preparation and properties of arginine-6 bovine pancreatic phospholipase A2. (1981) (35)
- Thermodynamic and conformational studies on sn-2-phosphatidylcholines in monolayers and bilayers. (1980) (35)
- Secretion of biologically active porcine prophospholipase A2 by Saccharomyces cerevisiae. Use of the prepro sequence of the alpha-mating factor. (1987) (34)
- Stimulus-response coupling in human platelets. Evidence against a role of PAF-acether in the "third pathway'. (1983) (34)
- Competitive inhibition of lipolytic enzymes. II. Preparation of 'monoacylamino' phospholipids. (1990) (34)
- Synthetic lecithins containing one short-chain fatty acid and their breakdown by phospholipase A. (1965) (33)
- Binding of porcine pancreatic phospholipase A2 to various micellar substrate analogues. Involvement of histidine-48 and aspartic acid-49 in the binding process. (1981) (32)
- Comparative studies of tyrosine modification in pancreatic phospholipases. 2. Properties of the nitrotyrosyl, aminotyrosyl, and dansylaminotyrosyl derivatives of pig, horse, and ox phospholipases A2 and their zymogens. (1979) (32)
- The isolation and properties of two prephospholipases A2 from porcine pancreas. (1973) (31)
- The amino acid sequence of the phospholipase A2 isoenzyme from porcine pancreas. (1979) (30)
- Proton-nuclear-magnetic-resonance/pH-titration studies of the histidines of pancreatic phospholipase A2. (1979) (30)
- Phospholipase A2 inhibitors: monoacyl, monoacylamino-glycero-phosphocholines. (1989) (30)
- Rotational dynamics of the single tryptophan of porcine pancreatic phospholipase A2, its zymogen, and an enzyme/micelle complex. A steady-state and time-resolved anisotropy study. (1988) (30)
- Kinetic behavior of porcine pancreatic phospholipase A2 on zwitterionic and negatively charged double-chain substrates. (1985) (30)
- Regulation of phospholipase A2 activity by different lipid-water interfaces. (1977) (29)
- Site-specific epsilon-NH2 monoacylation of pancreatic phospholipase A2. 2. Transformation of soluble phospholipase A2 into a highly penetrating "membrane-bound" form. (1988) (29)
- The size and shape of micelles of some synthetic phospholipids in aqueous dispersions. (1965) (28)
- Synthesis and enzymic hydrolysis of an O-alanyl ester of phosphatidyl glycerol. (1965) (27)
- Evidence for the involvement of tyrosine-69 in the control of stereospecificity of porcine pancreatic phospholipase A2. (1989) (26)
- Localization of the second calcium ion binding site in porcine and equine phospholipase A2. (1983) (25)
- Comparative studies of tyrosine modification in pancreatic phospholipases. 1. Reaction of tetranitromethane with pig, horse, and ox phospholipases A2 and their zymogens. (1979) (25)
- Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Cleavage of a fusion protein with cyanogen bromide. (1992) (25)
- Synthetic and structural investigations on 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol. (1967) (25)
- Activities of native and tyrosine-69 mutant phospholipases A2 on phospholipid analogues. A reevaluation of the minimal substrate requirements. (1990) (25)
- Catalytic Ca2+-binding site of pancreatic phospholipase A2: laser-induced Eu3+ luminescence study. (1985) (24)
- Properties of PAF-acether-induced platelet aggregation and secretion. Studies in gel-filtered human platelets. (1983) (23)
- Ajoene prevents fat digestion by human gastric lipase in vitro. (1989) (23)
- The importance of glycine-30 for enzymatic activity of phospholipase A2. (1991) (23)
- Function of the fully conserved residues Asp99, Tyr52 and Tyr73 in phospholipase A2. (1990) (23)
- Studies on the role of methionine in porcine pancreatic phospholipase A2. (1976) (23)
- Two-dimensional 1H-NMR studies of phospholipase-A2-inhibitor complexes bound to a micellar lipid-water interface. (1991) (22)
- A photochemically induced dynamic nuclear polarization study of pancreatic phospholipase A2. NMR assignment of some aromatic residues. (1978) (22)
- Effects of substitution of the absolutely invariant glutamine-4 and phenylalanine-5 in bovine pancreatic phospholipase A2 on enzymatic activity and substrate binding properties. (1982) (22)
- Immunological studies on pancreatic phospholipase A2. Antigenic characterization of the NH2-terminal region. (1978) (22)
- A monolayer and bulk study on the kinetic behavior of Pseudomonas glumae lipase using synthetic pseudoglycerides. (1991) (22)
- Lipase regio- and stereoselectivities toward three enantiomeric pairs of didecanoyl-deoxyamino-O methyl glycerol: a kinetic study by the monomolecular film technique. (2003) (22)
- Arginine 53 is involved in head-group specificity of the active site of porcine pancreatic phospholipase A2. (1993) (22)
- Selective elimination of malaria infected erythrocytes by a modified phospholipase A2 in vitro. (1990) (22)
- THE SUBSTRATE SPECIFICITY OF PHOSPHOLIPASE A. (1963) (21)
- Glutamic acid 71 and aspartic acid 66 control the binding of the second calcium ion in porcine pancreatic phospholipase A2. (1989) (21)
- Inactivation of Staphylococcus hyicus lipase by hexadecylsulfonyl fluoride: evidence for an active site serine. (1994) (21)
- 1H-NMR and photochemically-induced dynamic nuclear polarization studies on bovine pancreatic phospholipase A2. (1980) (20)
- Porcine pancreatic phospholipase A2: sequence-specific 1H and 15N NMR assignments and secondary structure. (1991) (20)
- Site-specific epsilon-NH2 monoacylation of pancreatic phospholipase A2. 1. Preparation and properties. (1988) (19)
- Hydrolysis of synthetic phosphatides by Clostridium welchii phosphatidase. (1961) (19)
- Phase properties of the aqueous dispersions of n-octadecylphosphocholine. (1985) (19)
- Inactivation of Escherichia coli outer-membrane phospholipase A by the affinity label hexadecanesulfonyl fluoride. Evidence for an active-site serine. (1991) (19)
- Unusual kinetic behavior of porcine pancreatic (pro)phospholipase A2 on negatively charged substrates at submicellar concentrations. (1983) (19)
- Semisynthesis of phospholipase A2. The effect of substitution of amino-acid residues at positions 6 and 7 in bovine and porcine pancreatic phospholipases A2 on catalytic and substrate-binding properties. (1983) (18)
- Influence of size and polarity of residue 31 in porcine pancreatic phospholipase A2 on catalytic properties. (1990) (18)
- A Fourier transform infrared spectroscopic (FTIR) study of porcine and bovine pancreatic phospholipase A2 and their interaction with substrate analogues and a transition-state inhibitor. (1990) (18)
- Modification of arginine residues in porcine pancreatic phospholipase A2. (1981) (17)
- Conformational differences between sn-3-phospholipids and sn-2-phospholipids. A neutron and x-ray diffraction investigation. (1982) (17)
- Chemical modification of Lys-6 in phospholipase A2 from Naja melanoleuca snake venom. (1983) (17)
- Regulation of the interaction of pancreatic phospholipase A2 with lipid-water interfaces by Ca2+ ions: a monolayer study. (1979) (17)
- Optical rotatory dispersion and circular dichroism of phospholipase A2 and its zymogen from porcine pancreas. (1969) (17)
- Regeneration of full enzymatic activity by reoxidation of reduced pancreatic phospholipase A2. (1980) (17)
- The use of genetic engineering to obtain efficient production of porcine pancreatic phospholipase A2 by Saccharomyces cerevisiae. (1991) (16)
- Structural importance of the amino-terminal residue of pancreatic phospholipase A2. (1984) (16)
- Crystal structure of a porcine pancreatic phospholipase A2 mutant. A large conformational change caused by the F63V point mutation. (1993) (15)
- Competitive inhibition of lipolytic enzymes. V. A monolayer study using enantiomeric acylamino analogues of phospholipids as potent competitive inhibitors of porcine pancreatic phospholipase A2. (1992) (15)
- Rat platelet phospholipase A2. Kinetic characterization using the monomolecular film technique. (1992) (15)
- Cloning, expression, and purification of porcine pancreatic phospholipase A2 and mutants. (1991) (14)
- Characterization of phospholipases A2 of Naja melanoleuca snake venom modified at the N-terminal region. (1984) (12)
- Acylation of porcine pancreatic phospholipase A2 influences penetration and substrate head-group binding, depending on the position of the acylated lysine in the enzyme molecule. (1993) (12)
- Interaction of pancreatic phospholipases A2 and semisynthetic mutants with anionic substrates and substrate analogues. (1987) (12)
- Overproduction and high-yield purification of phospholipase A from the outer membrane of Escherichia coli K-12. (1986) (12)
- Site-directed mutagenesis and X-ray crystallography of two phospholipase A2 mutants: Y52F and Y73F. (1992) (12)
- Amino acid sequence of phospholipase A from porcine pancreas. (1969) (12)
- Amino acid substitutions of the NH2-terminal Ala1 of porcine pancreatic phospholipase A2: a monolayer study. (1979) (11)
- Competitive inhibition of lipolytic enzymes. VI. Inhibition of two human phospholipases A2 by acylamino phospholipid analogues. (1992) (11)
- Chiral preference of cutinase in the reaction with phosphonate inhibitors. (1997) (11)
- Circular dichroism of porcine, bovine, and equine pancreatic phospholipases A2 and their zymogens. Unusual conformations simulating helix content. (1977) (11)
- Interaction of native and modified Naja melanoleuca phospholipases A2 with the fluorescent probe 8-anilinonaphtalene-1-sulfonate. (1984) (10)
- Competitive inhibition of lipolytic enzymes. IX. A comparative study on the inhibition of pancreatic phospholipases A2 from different sources by (R)-2-acylamino phospholipid analogues. (1993) (10)
- Effects of phospholipase A and pre-phospholipase A on black phospholipid membranes. (1968) (10)
- Side-chain dynamics of two aromatic amino acids in pancreatic phospholipase A2 as studied by deuterium nuclear magnetic resonance. (1985) (9)
- Relationship between structure and activity of pancreatic phospholipase A2. (1978) (8)
- Interaction of phospholipase A2 and its zymogen with divalent metal ions. (1974) (8)
- Changes in activity of porcine phospholipase A2 brought about by charge engineering of a major structural element to alter stability. (1991) (8)
- The synthesis of phosphoglycerides and some biochemical applications. (1964) (8)
- Activation of reconstituted Escherichia coli outer-membrane phospholipase A by membrane-perturbing peptides results in an increased reactivity towards the affinity label hexadecanesulfonyl fluoride. (1991) (8)
- Competitive inhibition of lipolytic enzymes. VII. The interaction of pancreatic phospholipase A2 with micellar lipid/water interfaces of competitive inhibitors. (1992) (7)
- Structure and thermodynamic properties of the complexes between phospholipase A2 and lipid micelles. (1979) (7)
- Investigation of phospholipase‐lipid interactions by optical detection of triplet state magnetic resonance spectroscopy (1985) (6)
- Competitive inhibition of lipolytic enzymes. X. Further delineation of the active site of pancreatic phospholipases A2 from pig, ox and horse by comparing the inhibitory power of a number of (R)-2-acylamino phospholipid analogues. (1994) (6)
- Competitive inhibition of lipolytic enzymes. XI. Estimation of the interfacial dissociation constants of porcine pancreatic phospholipase A2 for substrate and inhibitor in the absence of detergents. (1995) (5)
- NMR studies of interactions between inhibitors and porcine pancreatic phospholipase A2. (1992) (5)
- Identification of the active site histidine in Staphylococcus hyicus lipase using chemical modification and mass spectrometry. (1995) (5)
- Optically detected magnetic resonance studies of porcine pancreatic phospholipase A2 binding to a negatively charged substrate analogue. (1986) (5)
- Stereospecificity of the interaction of porcine pancreatic phospholipase A2 with micellar and monomeric inhibitors. A time-resolved fluorescence study of the tryptophan residue. (1993) (5)
- Comparative optically detected magnetic resonance studies of mammalian phospholipase A2‐lipid interactions (1987) (5)
- Evidence that the zymogen of phospholipase A2 binds to a negatively charged lipid-water interface. (1984) (5)
- Interaction of phospholipase A2 from Naja melanoleuca snake venom with monomeric substrate analogs. Activation of the enzyme by protein-protein or lipid-protein interactions? (1983) (4)
- Competitive inhibition of lipolytic enzymes. VIII: Inhibitor-induced aggregation of porcine pancreatic phospholipase A2. (1992) (4)
- Probing the mechanism of pancreatic phospholipase A2 with the aid of recombinant DNA techniques. (1990) (4)
- Activation of human spleen glucocerebrosidases by monoacylglycol sulfates and diacylglycerol sulfates. (1988) (4)
- Interaction of phospholipase A2 with lipid-water interfaces. (1978) (3)
- Studies of lipase and phospholipase A2 acting on lipid monolayers. (1978) (3)
- The fluorimetric determination of the kinetic parameters Km and kcat of the tryptic activation of prephospholipase A2 and derivatives. (1973) (3)
- Purification and properties of phospholipase A and its zymogen from porcine pancreas. (1968) (3)
- Effect of selective chemical modification and CNBr-cleavage at methionine20 in catalytic activity and substrate binding properties of porcine pancreatic phospholipase A2. (1988) (2)
- The interaction of phospholipase A with lipids. I. Structure of the bimolecular leaflet of a lecithin analogue substance, 1-oleoyl-2-n-hexadecyl-2-deoxy-glycero-3-phosphorylcholine. (1973) (2)
- Kinetic behavior of porcine pancreatic phospholipase A2 on zwitterionic and negatively charged single-chain substrates. (1985) (2)
- Effects of ligand binding on the conformation and internal dynamics in specific regions of porcine pancreatic phospholipase A2 with tryptophan as a probe: a study combinging time-resolved fluorescence spectroscopy and site-directed mutagenesis (same as p. 628) (1990) (2)
- Structure and enzymic properties of phospholipase A from porcine pancreas. (1972) (2)
- Automated proton titrations of pancreatic phospholipase A2. (1982) (2)
- Effects of ligand binding on the conformation and internal dynamics in specific regions of porcine pancreatic phospholipase A2 with tryptophan as a probe: a study combining time-resolved fluorescence spectroscopy and site-directed mutagenesis (same as p. 100) (1990) (1)
- Structural identification of isomeric lysolecithins. (1965) (1)
- Phospholipase A2 isoenzyme from porcine pancreas. Purification and some properties. (1975) (1)
- THE SITE OF ACTION OF PHOSPHOLIPASE A ON BETA-LECITHINS. (1964) (0)
- THE STEREOSPECIFIC ACTION OF PHOSPHOLIPASE A ON BETA-LECITHINS. (1963) (0)
- Chemical Structure and Serological Activity of Synthetic and Natural Cardiolipin (1965) (0)
- Phospholipase A and its zymogen from porcine pancreas. (1972) (0)
- The mode of action of phospholipase A on synthetic "mixed-acid" L-alpha-phosphatidyl ethanolamines. (1961) (0)
- [THE MODE OF ACTION OF PHOSPHOLIPASE A FROM SNAKE VENOM ON ELAIDIN SUBSTRATES]. (1964) (0)
- Microcomputer interface for computer-controlled enzyme kinetic studies with the monolayer technique. (1984) (0)
- Regulation of phospholipase A2 activity by different lipid-water interfaces. (1977) (0)
- Nuclear magnetic resonance studies of the aggregation of dihexanoyllecithin and of diheptanolyllecithin in aqueous solutions. (1976) (0)
- Application of mass spectrometry to the analysis of proteins containing a N‐terminal pyroglutamic acid residue (1969) (0)
This paper list is powered by the following services:
