Gerard Johan Mulder
#158,039
Most Influential Person Now
Gerard Johan Mulder's AcademicInfluence.com Rankings
Gerard Johan Mulderbiology Degrees
Biology
#12298
World Rank
#15765
Historical Rank
Cell Biology
#645
World Rank
#659
Historical Rank
Molecular Biology
#1980
World Rank
#2012
Historical Rank
Biochemistry
#2086
World Rank
#2230
Historical Rank
Download Badge
Biology
Gerard Johan Mulder's Degrees
- PhD Biochemistry University of Amsterdam
- Masters Biomedical Sciences Utrecht University
- Bachelors Biology Leiden University
Similar Degrees You Can Earn
Why Is Gerard Johan Mulder Influential?
(Suggest an Edit or Addition)Gerard Johan Mulder's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. (1997) (304)
- The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. (1991) (257)
- UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions. (1983) (190)
- Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues. (1994) (156)
- Glucuronidation and its role in regulation of biological activity of drugs. (1992) (150)
- A rapid NAD+-linked assay for microsomal uridine diphosphate glucuronyltransferase of rat liver and some observations on substrate specificity of the enzyme. (1975) (142)
- Phenol sulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo and vitro. 2,6-Dichloro-4-nitrophenol as selective inhibitor of sulphation. (1977) (119)
- [11] Isolated perfused rat liver technique (1981) (113)
- Conjugation reactions in drug metabolism : an integrated approach : substrates, co-substrates, enzymes and their interactions in vivo and in vitro (1990) (108)
- Differential Regulation of Doxorubicin-induced Mitochondrial Dysfunction and Apoptosis by Bcl-2 in Mammary Adenocarcinoma (MTLn3) Cells* (2002) (99)
- Generation of reactive metabolites of N-hydroxy-phenacetin by glucoronidation and sulfation. (1977) (98)
- Abstract of papers (2005) (97)
- Dose-dependent shifts in the sulfation and glucuronidation of phenolic compounds in the rat in vivo and in isolated hepatocytes. The role of saturation of phenolsulfotransferase. (1981) (94)
- New developments in glucuronidation research: Report of a workshop on “Glucuronidation, its role in health and disease” (1992) (94)
- Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine. (1994) (90)
- The effect of phenobarbital on the submicrosomal distribution of uridine diphosphate glucuronyltransferase from rat liver. (1970) (87)
- The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and gamma-glutamyl domains. (1990) (87)
- Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes. (1994) (86)
- Alteration of urinary levels of the carcinogen, N-hydroxy-2-naphthylamine, and its N-glucuronide in the rat by control of urinary pH, inhibition of metabolic sulfation, and changes in biliary excretion. (1981) (86)
- p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion. (1997) (85)
- Formation and identification of glutathione conjugates from 2-nitrosofluorene and N-hydroxy-2-aminofluorene. (1982) (80)
- Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacologic evaluation of treatment with high dose melphalan in patients with colorectal cancer confined to the liver (2000) (80)
- Cisplatin effects on F-actin and matrix proteins precede renal tubular cell detachment and apoptosis in vitro (1998) (77)
- UDP glucuronyltransferase and phenolsulfotransferase in vivo and in vitro. Conjugation of harmol and harmalol. (1974) (71)
- Role of sulfation in the formation of DNA adducts from N-hydroxy-2-acetylaminofluorene in rat liver in vivo. Inhibition of N-acetylated aminofluorene adduct formation by pentachlorophenol. (1981) (70)
- Inhibition of sulfate conjugation of N-hydroxy-2-acetylaminofluorene in isolated perfused rat liver and in the rat in vivo by pentachlorophenol and low sulfate. (1980) (70)
- GLUTATHIONE CONJUGATES AND THEIR SYNTHETIC DERIVATIVES AS INHIBITORS OF GLUTATHIONE-DEPENDENT ENZYMES INVOLVED IN CANCER AND DRUG RESISTANCE (2002) (68)
- Cleavage of the Actin-capping Protein α-Adducin at Asp-Asp-Ser-Asp633-Ala by Caspase-3 Is Preceded by Its Phosphorylation on Serine 726 in Cisplatin-induced Apoptosis of Renal Epithelial Cells* (2000) (65)
- Normal and retrograde perfusion to probe the zonal distribution of sulfation and glucuronidation activities of harmol in the perfused rat liver preparation. (1983) (64)
- Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism, PhIP-DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes. (1994) (64)
- Absorption, serum levels and urinary excretion of inorganic sulfate after oral administration of sodium sulfate in the conscious rat. (1979) (63)
- Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N,O-sulfonation in chemical carcinogenesis of aromatic amines. (1983) (62)
- Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells: studies on involvement of adenosine receptors and adenosine uptake. (2001) (60)
- Conversion of the N-Q-glucuronide and N-O-sulfate conjugates of N-hydroxyphenacetin to reactive intermediates. (1978) (59)
- Modulation of glutathione conjugation in vivo: how to decrease glutathione conjugation in vivo or in intact cellular systems in vitro. (1997) (59)
- Aberrant Pharmacokinetics of harmol in the perfused rat liver preparation: sulfate and glucuronide conjugations. (1981) (58)
- Sex differences in drug conjugation and their consequences for drug toxicity. Sulfation, glucuronidation and glutathione conjugation. (1986) (57)
- Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium. (1993) (56)
- Renal proximal tubular cells in suspension or in primary culture as in vitro models to study nephrotoxicity. (1990) (54)
- AVAILABILITY OF INORGANIC SULFATE AS A RATE LIMITING FACTOR IN THE SULFATE CONJUGATION OR XENOBIOTICS IN THE RAT - SULFATION AND GLUCURONIDATION OF PHENOL (1979) (53)
- Hepatotoxicity of tetrahydroaminoacridine in isolated rat hepatocytes: effect of glutathione and vitamin E. (1988) (53)
- Glutathione conjugation of 4-hydroxy-trans-2,3-nonenal in the rat in vivo, the isolated perfused liver and erythrocytes. (1999) (52)
- The availability of inorganic sulphate in blood for sulphate conjugation of drugs in rat liver in vivo. (35S)Sulphate incorporation into harmol sulphate. (1978) (52)
- An evaluation of methods to decrease the availability of inorganic sulphate for sulphate conjugation in the rat in vivo. (1981) (51)
- SERUM CONCENTRATION OF INORGANIC SULFATE IN MAMMALS - SPECIES-DIFFERENCES AND CIRCADIAN-RHYTHM (1980) (51)
- Prevention of the hepatotoxic action of N-hydroxy-2-acetylaminofluorene in the rat by inhibition of N-O-sulfation by pentachlorophenol. (1981) (51)
- The oxidation of L- and D-cysteine to inorganic sulfate and taurine in the rat. (1981) (51)
- Identification of glutathione conjugates formed from N-hydroxy-2-acetylaminofluorene in the rat. (1982) (51)
- Isolated proximal tubular cells from rat kidney as an in vitro model for studies on nephrotoxicity. I. An improved method for preparation of proximal tubular cells and their functional characterization by alpha-methylglucose uptake. (1989) (51)
- Pharmacological effects of drug conjugates: is morphine 6-glucuronide an exception? (1992) (51)
- Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N‐acetyltransferase and glutathione S‐transferase activities (2004) (49)
- The role of metallothionein in the reduction of cisplatin-induced nephrotoxicity by Bi3(+)-pretreatment in the rat in vivo and in vitro. Are antioxidant properties of metallothionein more relevant than platinum binding? (1991) (49)
- Toxicity of the cysteine-S-conjugates and mercapturic acids of four structurally related difluoroethylenes in isolated proximal tubular cells from rat kidney. Uptake of the conjugates and activation to toxic metabolites. (1989) (48)
- Use of pentachlorophenol as long-term inhibitor of sulfation of phenols and hydroxamic acids in the rat in vivo. (1983) (48)
- Role of sulfotransferase from rat liver in the mutagenicity of N-hydroxy-2-acetylaminofluorene in Salmonella typhimurium (1977) (46)
- Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevent hepatotoxin-induced cell death in isolated rat hepatocytes. A study with allyl alcohol, tert-butyl hydroperoxide, diethyl maleate, bromoisovalerylurea and carbon tetrachloride. (1988) (44)
- Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis. (1995) (44)
- Metabolism of inorganic sulphate in the isolated perfused rat liver. Effect of sulphate concentration on the rate of sulphation by phenol sulphotransferase. (1978) (43)
- Glucuronidation and sulfation in the rat in vivo. The role of the liver and the intestine in the in vivo clearance of 4-methylumbelliferone. (1985) (42)
- Collection of metabolites in bile and urine from the rat. (1981) (41)
- Peptidomimetic Glutathione Analogues as Novel γGT Stable GST Inhibitors (2002) (40)
- Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling. (2006) (40)
- Lipid peroxidation-dependent and -independent protein thiol modifications in isolated rat hepatocytes: differential effects of vitamin E and disulfiram. (1989) (40)
- Effects of variation in the dietary supply of cysteine and methionine on liver concentration of glutathione and "active sulfate" (PAPS) and serum levels of sulfate, cystine, methionine and taurine: relation to the metabolism of acetaminophen. (1983) (39)
- Effect of glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by melphalan (L-phenylalanine mustard) in human colorectal cancer cells. (1999) (38)
- Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation. (1986) (38)
- Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells. (2001) (38)
- Substrate specificity of rat liver glutathione S-transferase isoenzymes for a series of glutathione analogues, modified at the gamma-glutamyl moiety. (1988) (37)
- The heterogeneity of uridine diphosphate glucuronyltransferase from rat liver. (1971) (37)
- Health risk assessment of exposure to TriCresyl Phosphates (TCPs) in aircraft: a commentary. (2014) (37)
- Isolated perfused rat liver technique. (1981) (36)
- Loss of nuclear p53 protein in preneoplastic rat hepatocytes is accompanied by Mdm2 and Bcl‐2 overexpression and by defective response to DNA damage in vivo (2000) (36)
- Primary culture of proximal tubular cells from normal rat kidney as an in vitro model to study mechanisms of nephrotoxicity. Toxicity of nephrotoxicants at low concentrations during prolonged exposure. (1990) (36)
- Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat. (2000) (36)
- Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors. (1999) (36)
- Reaction of mutagenic phenacetin metabolites with glutathione and DNA. Possible implications for toxicity. (1984) (35)
- Prolonged high intracellular free calcium concentrations induced by ATP are not immediately cytotoxic in isolated rat hepatocytes. Changes in biochemical parameters implicated in cell toxicity. (1989) (34)
- Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: the effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes. (1999) (34)
- In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function. (1994) (33)
- Interaction of rat glutathione S-transferases 7-7 and 8-8 with gamma-glutamyl- or glycyl-modified glutathione analogues. (1989) (33)
- Involvement of intracellular Ca2+ and K+ in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes. (1992) (32)
- Secretion of the organic anion harmol sulfate from liver into blood. Evidence for a carrier-mediated mechanism. (1985) (32)
- The dependence of the rate of sulphate conjugation on the plasma concentration of inorganic sulphate in the rat in vivo. (1982) (31)
- The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine. (1993) (31)
- Inhibition of the multidrug resistance protein 1 (MRP1) by peptidomimetic glutathione-conjugate analogs. (2002) (30)
- Apoptosis induced by extracellular ATP in the mouse neuroblastoma cell line N1E-115: studies on involvement of P2 receptors and adenosine. (2002) (30)
- The rate-limiting step in the biliary elimination of some substrates of uridine diphosphate glucuronyltransferase in the rat. (1973) (29)
- Sulfation: metabolic aspects (1984) (28)
- Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives. (2004) (28)
- Interleukin‐2–activated natural killer cells can induce both apoptosis and necrosis in rat hepatocytes (1999) (28)
- Isolated proximal tubular cells from rat kidney as an in vitro model for studies on nephrotoxicity. II. Alpha-methylglucose uptake as a sensitive parameter for mechanistic studies of acute toxicity by xenobiotics. (1989) (28)
- Formation of chemically reactive metabolites of phenacetin and acetaminophen. (1981) (27)
- Kinetics of sulfation and glucuronidation of harmol in the perfused rat liver preparation. Disappearance of aberrances in glucuronidation kinetics by inhibition of sulfation. (1982) (26)
- Alteration of transit time and direction of flow to probe the heterogeneous distribution of conjugating activities for harmol in the perfused rat liver preparation. (1985) (25)
- Effect of coexposure to methyl ethyl ketone (MEK) on n-hexane toxicokinetics in human volunteers. (1997) (25)
- In vivo characterization and modulation of the glutathione/glutathione S-transferase system in cancer patients. (1995) (24)
- Distinct Intracellular Signaling in Tumor Necrosis Factor-related Apoptosis-inducing Ligand- and CD95 Ligand-mediated Apoptosis* (2002) (24)
- Development of resistance to glutathione depletion-induced cell death in CC531 colon carcinoma cells: association with increased expression of bcl-2. (2000) (24)
- Glutathione analogues as novel inhibitors of rat and human glutathione S-transferase isoenzymes, as well as of glutathione conjugation in isolated rat hepatocytes and in the rat in vivo. (1995) (24)
- Selective inhibition of sulfate conjugation in the rat: pharmacokinetics and characterization of the inhibitory effect of 2,6-dichloro-4-nitrophenol. (1982) (24)
- Glutathione conjugation of bromosulfophthalein in relation to hepatic glutathione content in the rat in vivo and in the perfused rat liver. (1995) (23)
- Inhibition of acetaminophen sulfation by 2,6-dichloro-4-nitrophenol in the perfused rat liver preparation. Lack of a compensatory increase of glucuronidation. (1984) (23)
- The role of various Bcl‐2 domains in the anti‐proliferative effect and modulation of cellular glutathione levels: a prominent role for the BH4 domain (2003) (22)
- Chapter 13 – Conjugation of Phenols (1982) (22)
- Inhibition of rat liver glutathione S-transferase isoenzymes by peptides stabilized against degradation by gamma-glutamyl transpeptidase. (1991) (22)
- Inhibition of UDP-glucuronosyltransferase activity by possible transition-state analogues in rat-liver microsomes. (1990) (22)
- Reduced Liver Uptake of Arterially Infused Melphalan during Retrograde Rat Liver Perfusion with Unaffected Liver Tumor Uptake (2002) (22)
- Inhibition of the oxidative metabolism of theophylline in isolated rat hepatocytes by the quinolone antibiotic enoxacin and its metabolite oxoenoxacin, but not by ofloxacin. (1988) (22)
- Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo. (2004) (21)
- Inhibition of glutathione S-transferase in rat hepatocytes by a glycine-tetrazole modified S-alkyl-GSH analogue. (2002) (21)
- Effect of ifosfamide treatment on glutathione and glutathione conjugation activity in patients with advanced cancers. (1995) (21)
- Bilirubin and heterogeneity of microsomal uridine diphosphate glucuronyltransferase from rat liver. (1972) (21)
- Melphalan Antitumor Efficacy and Hepatotoxicity: The Effect of Variable Infusion Duration in the Hepatic Artery (2003) (21)
- alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. I. (Bio-) synthesis, analysis and identification of diastereomeric glutathione conjugates and mercapturates. (1986) (21)
- High-rate intestinal conjugation of 4-methylumbelliferone during intravenous infusion in the rat in vivo. (1984) (21)
- Modulation of cytostatic efficacy of melphalan by glutathione: mechanisms and efficacy. (2002) (21)
- Liquid chromatographic determination of diastereomeric glutathione conjugates and further derivatives of alpha-bromoisovalerylurea in rat bile and urine by electrochemically generated bromine. (1988) (20)
- Competition between sulphation and glucuronidation in the rat in vivo: enzyme kinetics and pharmacokinetics of conjugation. (1984) (20)
- Stereoselectivity of rat liver glutathione transferase isoenzymes for alpha-bromoisovaleric acid and alpha-bromoisovalerylurea enantiomers. (1988) (20)
- D-cysteine as a selective precursor for inorganic sulfate in the rat in vivo. Effect of D-cysteine on the sulfation of harmol. (1984) (19)
- Stereoselective glutathione conjugation of the separate α-bromoisovalerylurea and α-bromoisovaleric acid enantiomers in the rat in vivo and in rat liver subcellular fractions (1988) (19)
- Localization of glutathione conjugation activities toward bromosulfophthalein in perfused rat liver. Studies with the multiple indicator dilution technique. (1993) (19)
- Methods for the quantitation of bromosulfophthalein and its glutathione conjugate in biological fluids. (1993) (19)
- Selective and potent inhibition of different hepatic UDP-glucuronosyltransferase activities by ω,ω,ω,-triphenylalcohols and UDP derivatives (1992) (18)
- Extrahepatic sulfation and glucuronidation in the rat in vivo. Determination of the hepatic extraction ratio of harmol and the extrahepatic contribution to harmol conjugation. (1984) (18)
- alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver. (1986) (18)
- The role of specific DNA adducts in the induction of micronuclei by N-hydroxy-2-acetylaminofluorene in rat liver in vivo. (1989) (17)
- Iodonium Ion Promoted Reactions at the Anomeric C-2 Center of 1-Methylene Sugars (1990) (17)
- Synthesis and nucleophilic reactivity of a series of glutathione analogues, modified at the gamma-glutamyl moiety. (1988) (17)
- Stereoselectivity of glutathione conjugation: blood elimination of alpha-bromoisovalerylurea enantiomers and biliary excretion of the conjugates in unanesthetized normal or congenitally jaundiced rats. (1989) (17)
- The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver. (1988) (17)
- Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene (2005) (17)
- Risk assessment of carcinogenic chemicals in The Netherlands. Health Council of The Netherlands: Committee on the Evaluation of the Carcinogenicity of Chemical Substances. (1994) (17)
- Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme. (1996) (17)
- Sulfation of hydroxylamines and hydroxamic acids in liver cytosol from male and female rats and purified aryl sulfotransferase IV. (1992) (17)
- Sex differences in sulfation and glucuronidation of phenol, 4-nitrophenol and N-hydroxy-2-acetylaminofluorene in the rat in vivo. (1987) (16)
- Relationship between glutathione content in liver and glutathione conjugation rate in the rat in vivo. Effect of buthionine sulphoximine pretreatment on conjugation of the two 2-bromoisovalerylurea enantiomers during intravenous infusion. (1992) (16)
- Evaluation of nephrotoxicity in vitro using a suspension of highly purified porcine proximal tubular cells and characterization of the cells in primary culture. (1994) (16)
- UDP glucuronyltransferase and phenolsulfotransferase from rat liver in vivo and in vitro--IV. Species differences in harmol conjugation and elimination in bile and urine in vivo. (1975) (16)
- Synthesis and inhibitory effect of a trisubstrate transition state analogue for UDP glucuronosyltransferases (1997) (15)
- Stereoselectivity in the urinary excretion of the mercapturates of (R-) and (S-) alpha-bromoisovalerylurea in man. (1989) (15)
- A rapid, simple in vitro screening test, using [(3)H]glutathione and l-[(35)S]cysteine as trapping agents, to detect reactive intermediates of xenobiotics. (1988) (15)
- Lack of glutathione conjugation of melphalan in the isolated in situ liver perfusion in humans. (1996) (15)
- The covalent binding of cyclosporin A to rat liver macromolecules in vivo and in vitro: the role of cytochrome P-450. (1987) (15)
- Potentiation of the cytostatic effect of melphalan on colorectal cancer hepatic metastases by infusion of buthionine sulfoximine (BSO) in the rat Enhanced tumor glutathione depletion by infusion of BSO in the hepatic artery (1999) (15)
- Role of microtubuli in secretion of very‐low‐density lipoprotein in isolated rat hepatocytes: Early effects of thiol reagents (1991) (15)
- Reaction of 2-acetylaminofluorene-N-sulfate with RNA and glutathione: evidence for the generation of two reactive intermediates with different reactivities towards RNA and glutathione. (1985) (14)
- Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue. (2003) (14)
- Detoxification or toxification? modification of the toxicity of foreign compounds by conjugation in the liver (1979) (14)
- Inhibition of glutathione S-transferase 3-3 by glutathione derivatives that bind covalently to the active site. (1991) (13)
- On non-specific inhibition of rat liver microsomal UDP glucuronyltransferase by some drugs. (1974) (13)
- Apparent aberrancy in the kinetics of intracellular metabolism of a single substrate by two enzymes. An alternative explanation for anomalies in the kinetics of sulfation and glucuronidation. (1982) (13)
- Peptidomimetic glutathione analogues as novel gammaGT stable GST inhibitors. (2002) (13)
- The availability of inorganic sulphate as a rate limiting factor in the sulphate conjugation of xenobiotics in the rat? Sulphation and glucuronidation of phenol. (1979) (13)
- Heterogeneity of Hepatic Microsomal Uridine Diphosphate Glucuronyltransferase: A Critical Evaluation (1974) (13)
- Prevention by thioethers of the hepatotoxicity and covalent binding to macromolecules of N-hydroxy-2-acetylaminofluorene and its sulfate ester in rat liver in vivo and in vitro. (1987) (12)
- Stereoselective glutathione conjugation and amidase-catalyzed hydrolysis of alpha-bromoisovalerylurea enantiomers in isolated rat hepatocytes. (1987) (12)
- Lack of p53 protein expression in preneoplastic rat hepatocytes in vitro after exposure to N-acetoxy-acetylaminofluorene, X-rays or a proteasome inhibitor. (2000) (12)
- Cholestatic effect of harmol glucuronide in the rat. Prevention of harmol-induced cholestasis by increased formation of harmol sulfate. (1982) (12)
- Immobilization of solubilized UDP-glucuronosyltransferase from rat liver microsomes to Sepharose 4B. (1992) (12)
- Bcl-2 Overexpression Does Not Prevent but Retards Adriamycin Toxicity in CC531 Colon Carcinoma Cells (2003) (12)
- An experimental minimally invasive perfusion technique for the treatment of liver metastases. (2003) (12)
- Extracellular calcium alleviates cell toxicity due to hepatotoxins that induce lipid peroxidation, but has no effect on toxins that do not cause lipid peroxidation. A study in isolated rat hepatocytes. (1989) (12)
- Intramolecular Ritter-Like Reaction at the Anomeric Center of a Heptulose Derivative (1992) (12)
- Bioactivation of Xenobiotics by Conjugation (1986) (11)
- Acetaminophen protects human erythrocytes against oxidative stress. (1988) (11)
- Inhibition of sulfation of phenols in vivo by 2,6-dichloro-4-nitrophenol: selectivity of its action in relation to other conjugations in the rat in vivo. (1979) (11)
- Glutathione conjugation of the alpha-bromoisovaleric acid enantiomers in the rat in vivo and its stereoselectivity. Pharmacokinetics of biliary and urinary excretion of the glutathione conjugate and the mercapturate. (1989) (10)
- UDP glucuronyltransferase and phenolsulfotransferase from rat liver in vivo and in vitro. III. The effect of phenolphthalein and its sulfate and glucuronide conjugate on conjugation and biliary excretion of harmol. (1975) (10)
- UDP glucuronyltransferase and phenolsulfotransferase from rat liver in vivo and in vitro. Characterization of conjugation and biliary excretion of harmol in vivo and in the perfused liver. (1975) (10)
- The fate of diastereomeric glutathione conjugates of alpha-bromoisovalerylurea in blood in the rat in vivo and in the perfused liver. Stereoselectivity in biliary and urinary excretion. (1991) (9)
- Studies on the activity and activation of rat liver microsomal glutathione transferase with a series of glutathione analogues. (1991) (9)
- Characterization of glutathione conjugation in humans: Stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)‐ and (S)‐2‐bromoisovalerylurea in healthy volunteers (1993) (9)
- Photoactivation of 2-nitrofluorene in vitro and in the rat in vivo. UVA-induced formation of reactive intermediates that bind covalently to RNA and protein. (1992) (9)
- Effect of phenobarbital treatment on lysosomal enzyme activity in rat liver. (1971) (9)
- Remodeling of the actin cytoskeleton of target hepatocytes and NK cells during induction of apoptosis. (2001) (9)
- Changes of G-actin localisation in the mitotic spindle region or nucleus during mitosis and after heat shock: a histochemical study of G-actin in various cell lines with fluorescent labelled vitamin D-binding protein. (1999) (9)
- Nuclear accumulation of G-actin in isolated rat hepatocytes by adenine nucleotides. (1997) (9)
- Fasting increases the susceptibility of rat hepatocytes to the cytotoxic effects of N-hydroxy-acetylaminofluorene. Effects on mitochondrial respiration and membrane potential. (1992) (9)
- Synthesis of a potential inhibitor of UDP-glucuronosyltransferase (1992) (9)
- Inhibition of glutathione conjugation in the rat in vivo by analogues of glutathione conjugates. (1998) (9)
- Stereoselectivity of human liver and intestinal cytosolic fractions as well as purified human glutathione S-transferase isoenzymes towards 2-bromoisovalerylurea enantiomers. (1993) (8)
- Isoenzyme-selective inhibition of glutathione conjugation in vivo: selective inhibition of the conjugation of S-2-Bromoisovalerylurea in the rat. (1996) (8)
- The effect of fasting on sulfation and glucuronidation in the rat in vivo. (1982) (8)
- Chiral inversion and stereoselective glutathione conjugation of the four 2-bromo-3-methylvaleric acid stereoisomers in the rat in vivo and in vitro. (1992) (8)
- The effect of hepatic blood flow on formation of metabolites. (1990) (8)
- Rat colon carcinoma cells that survived systemic immune surveillance are less sensitive to NK-cell mediated apoptosis (2004) (8)
- Immunohistochemical visualization of wild-type p53 protein in paraffin-embedded rat liver using tyramide amplification: zonal hepatic distribution of p53 protein after N-hydroxy-2-acetylaminofluorene administration. (1998) (7)
- Stereoselectivity in glutathione conjugation and amidase-catalyzed hydrolysis of the 2-bromoisovalerylurea enantiomers in the single-pass perfused rat liver. (1993) (7)
- Stereoselective glutathione conjugation by subcellular fractions and purified glutathione S-transferases. (1991) (7)
- Selective inhibition of glucuronidation by 2,2,2-triphenylethyl-UDP in isolated rat hepatocytes: conjugation of harmol, 3,3',5-triiodothyronine, and N-hydroxy-2-acetylaminofluorene. (1991) (7)
- On the localisation of d-tubocurarine in rat liver lysosomes in vivo by electron microscopy and subcellular fractionation (2004) (7)
- Biliary and urinary excretion of drug conjugates: effect of diuresis and choleresis on excretion of harmol sulphate and harmol glucuronide in the rat. (1979) (7)
- Noninvasive in vivo 13C-NMR spectroscopy in the rat to study the pharmacokinetics of 13C-labeled xenobiotics. (1992) (6)
- Differential effects of extracellular calcium on lipid peroxidation dependent (ethacrynic acid and allyl alcohol) and lipid peroxidation independent (disulfiram)-induced cytotoxicity in normal and vitamin E-deficient rat hepatocytes. (1993) (6)
- Bioactivation of 2-nitrofluorene to reactive intermediates that bind covalently to DNA, RNA and protein in vitro and in vivo in the rat. (1990) (6)
- Enantioselective determination of R- and S-(alpha-bromoisovaleryl)urea in plasma using high-performance liquid chromatography after solid-phase extraction. (1992) (6)
- Disposition of the bromosulfophthalein-glutathione conjugate in the isolated perfused rat kidney. (1995) (6)
- Cisplatin nephrotoxicity and platinum-metallothioneins: uptake and toxicity in proximal tubular cells from rat kidney. (1990) (6)
- Sulphation and glucuronidation of xamoterol in the dog: dose dependence and site of sulphation. (1988) (6)
- Inhibition of glutathione conjugation by glutathione analogues in the perfused rat liver. Effect of esterification on the potency of gamma-L-glutamyl-alpha-(D-2-aminoadipyl)-N-2-heptylamine. (1997) (6)
- Acetaminophen sulfation in patients with Parkinson's disease or Huntington's disease is not impaired (1993) (6)
- DNA adduct formation in liver following the administration of [3H]2-nitrofluorene to rats in vivo. (1991) (6)
- A method for comparison of the properties of UDP glucuronyltransferase and phenolsulfotransferase from rat liver, with a joint substrate (1975) (6)
- Isolation and Culture of Proximal Tubular Cells from Porcine Kidney (1993) (6)
- Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells. (2003) (5)
- Effect of sulphonylureas (tolazamide, tolbutamide and chlorpropamide) on the metabolism of diphenylhydantoin in the rat. (1973) (5)
- Health Council of the Netherlands. Deoxynivalenol (DON). (2001) (4)
- The Availability of Inorganic Sulfate for Sulfate Conjugation in Vivo (1981) (4)
- Autoradiographic studies on in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in rat liver containing gamma-glutamyltranspeptidase-positive foci. The effect of the sulfation-inhibitor pentachlorophenol. (1987) (4)
- Localization of d-tubocurarine in rat liver lysosomes (1977) (4)
- Kinetics of sulfation in the rat in vivo and in the perfused rat liver. (1986) (4)
- Allyl Alcohol and Acrolein Toxicity in Isolated Rat Hepatocytes is Independent of Lipid Peroxidation (1988) (4)
- Alpha-Methylglucose Uptake by Isolated rat Kidney Proximal Tubular Cells as a Parameter for Cell Integrity in Vitro (1989) (4)
- Generation of Reactive Intermediates from 2-Nitrofluorene that Bind Covalently to DNA, RNA and Protein in Vitro and in Vivo in the RAT (1990) (4)
- Stereoselectivity of glutathione conjugation in vivo, in the perfused liver and in isolated hepatocytes. (1991) (4)
- Noninvasive in vivo 13C-NMR spectroscopy of a 13C-labeled xenobiotic in the rat. (1992) (4)
- Stereoselective conjugation of 2-bromocarboxylic acids and their urea derivatives by rat liver glutathione transferase 12-12 and some other isoforms. (1992) (4)
- The binding of reactive metabolites of the carcinogen N-hydroxy-2-acetylaminofluorene to DNA and protein in isolated rat liver nuclei: effects of glutathione and methionine. (1986) (3)
- A scientific basis for the risk assessment of vinyl chloride. Developed jointly by the members of the Committee on the Evaluation of Carcinogenic Substances, National Health Council of The Netherlands. (1987) (3)
- The role of calpains in apoptotic changes in isolated hepatocytes after attack by Natural Killer cells. (2002) (3)
- Deuterium Isotope Effect on the Metabolism of the Flame Retardant Tris(2,3-dibromopropyl) Phosphate in the Isolated Perfused Rat Liver (1995) (3)
- Inhibition of glutathione efflux in the recirculating rat liver perfusion by cysteine but not by oxothiazolidine carboxylate, an intracellular cysteine precursor (1984) (2)
- Polymorphism in drug conjugation in man: is it a factor of concern in drug toxicity or efficacy? (1995) (2)
- A simple method of obtaining multiple blood samples from the portal vein and the hepatic vein in the rat in vivo (1983) (2)
- The Use of Porcine Proximal Tubular Cells for Studying Nephrotoxicity In Vitro: The Role of Oxidative Stress in Cisplatin-induced Cell Death (1996) (2)
- Pharmacokinetics of xamoterol glucuronidation in the rat in vivo and in liver perfusion. (1987) (2)
- Abnormal glutathione conjugation in patients with tyrosinaemia type I (1997) (2)
- Inhibition of sulphation of phenolic substances by the carboxylesterase inhibitor bis-(p-nitrophenyl)-phosphate in the rat in vivo. (1979) (2)
- RENAL PROXIMAL TUBULAR CELLS IN SIJSPENSION PRIMARY CULTURE AS IN VITRO MODELS TO STUDY NEPHROTOXICITY OR IN (1990) (2)
- Deuterium isotope effect on the metabolism of the flame retardant tris(2,3-dibromopropyl) phosphate in the isolated perfused rat liver. (1995) (2)
- Stereospecific glutathione conjugation of (R)- and (S)-2-bromoisovalerylurea in freshly isolated rat kidney proximal tubular cells. (1992) (2)
- Stereoselective glutathione conjugation of the separate alpha-bromoisovalerylurea and alpha-bromoisovaleric acid enantiomers in the rat in vivo and in rat liver subcellular fractions. (1988) (2)
- Peptidomimetic Glutathione Analogues as Novel γGT Stable GST Inhibitors. (2010) (1)
- IN VlVO CHARACTERIZATION AND MODULATION OF THE GLUTATHIONE/ SYSTEM IN CANCER PATIENTS* GLUTATHIONE S-TRANSFERASE (1995) (1)
- Glutathione conjugation and pharmacokinetics of 2-bromo-3-phenylpropionic acid in vitro and in the rat in vivo. (1992) (1)
- Generation of Reactive Intermediates from Xenobiotics by Sulfate Conjugation—their Potential Role in Chemical Carcinogenesis (2020) (1)
- Availability of Cosubstrates as a Rate-Limiting Factor (2020) (1)
- Selective Inhibition of Sulfation in Vivo (1981) (1)
- Interspecies Determinants : Bioactivation and Inactivation of Carcinogens (1)
- Sulfation of Drugs and Related Compounds (2020) (1)
- Stereoselectivity of rat liver glutathione transferase isoenzymes for x-bromoisovaleric acid and a-bromoisovalerylurea enantiomers (2005) (1)
- Designing experiments for food-drug synergy: Health aspects (2006) (1)
- Synthesis of potential UDP-glucuronosyltransferase inhibitors containing a diphosphate function (2010) (1)
- Synthesis of Potential UDP‐Glucuronosyltransferase Inhibitors Containing a Diphosphate Function (1991) (0)
- 292 – UDP GLUCURONYLTRANSFERASE AND PHENOLSULFOTRANSFERASE FROM RAT LIVER IN VITRO (1977) (0)
- Synthesis and Mutagenicity of Nitro-, Nitroso-, and Amino-Fluoranthenes (2010) (0)
- Adenosine-induced caspase activity in N1E-115 cells. (2000) (0)
- Selective inhibition of glucuronidation and sulfation in vitro and in vivo (1990) (0)
- ChemInform Abstract: Inhibition of Glutathione S-Transferase in Rat Hepatocytes by a Glycine-Tetrazole Modified S-Alkyl-GSH Analogue. (2002) (0)
- Abstracts of papers Toxicological meeting (2005) (0)
- Isolated hepatic perfusion for treatment of liver metastases: optimization and efficacy-testing of a novel, percutaneously applicable perfusion technique (PIHP) (2000) (0)
- Abstracts of papers pharmacological meeting (2005) (0)
- A method for comparison of the properties of UDP glucuronyltransferase from rat liver, with a joint substrate. (1975) (0)
- Molecular and cellular mechanisms in toxicology (2001) (0)
- Sulfation in Vivo and in Isolated Intact Cell Preparations (2020) (0)
- Sulfate metabolism and sulfate conjugation : proceedings of an International Workshop held at Noordwijkerhout, the Netherlands, 20-23 September, 1981 (1982) (0)
- Selective and potent inhibition of different hepatic UDP-glucuronosyltransferase activities by omega,omega,omega-triphenylalcohols and UDP derivatives. (1992) (0)
- Intramolecular Ritter‐Like Reaction at the Anomeric Center of a Heptulose Derivative. (1992) (0)
- UDP glucuronyltransferase. Properties and function in the elimination of its substrates in bile. (1973) (0)
- 5 Glucuronidation and anaesthesia (1998) (0)
- Focal adhesion kinase (FAK) and survival signaling in cytostatic-induced apoptosis of breast tumor cells (2001) (0)
- Iodonium Ion Promoted Reactions at the Anomeric C-2 Center of 1-Methylene Sugars. (1990) (0)
- Design, synthesis and in vitro evaluation of potential glutathione-S-transferase inhibitors (2001) (0)
- Moleculaire en cellulaire mechanismen in de toxicologie (2001) (0)
- 2594 – CONJUGATION OF DRUGS BY SULPHOTRANSFERASE IN RAT LIVER; THE AVAILABILITY OF INORGANIC SULPHATE AS A RATE LIMITING STEP (1978) (0)
- Abstracts of papers toxicological meeting (2005) (0)
- Another Jekyll and Hyde story? (1996) (0)
- Research in the division of toxicology (1985) (0)
- Reply to letter to the editor. (2015) (0)
- Stereoselectivity of glutathione conjugation in the rat in vivo (1990) (0)
- Drug-induced loss of cell-cell and cell-extracellular matrix interactions: implications for apoptosis (2000) (0)
- Sulfate Availability in Vivo (2020) (0)
This paper list is powered by the following services:
What Schools Are Affiliated With Gerard Johan Mulder?
Gerard Johan Mulder is affiliated with the following schools:
