Georges J. F. Köhler
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Georges J. F. Köhlerbiology Degrees
Biology
#5885
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#8472
Historical Rank
Immunology
#292
World Rank
#303
Historical Rank
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Biology
Why Is Georges J. F. Köhler Influential?
(Suggest an Edit or Addition)Georges J. F. Köhler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Continuous cultures of fused cells secreting antibody of predefined specificity (1975) (16547)
- Impaired immune and acute-phase responses in interleukin-6-deficient mice (1994) (1856)
- Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion (1976) (1836)
- A better cell line for making hybridomas secreting specific antibodies (1978) (1558)
- Disruption of the murine IL-4 gene blocks Th2 cytokine responses (1993) (1324)
- Fusion between immunoglobulin‐secreting and nonsecreting myeloma cell lines (1976) (652)
- IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. (1996) (633)
- CD22 is a negative regulator of B-cell receptor signalling (1997) (442)
- Transitional B cells are the target of negative selection in the B cell compartment (1995) (425)
- IL-4-deficient Balb/c mice resist infection with Leishmania major (1996) (316)
- Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein (1987) (305)
- Negative feedback regulation of IgE synthesis by murine CD23 (1994) (279)
- Impaired mucosal immune responses in interleukin 4-targeted mice. (1995) (258)
- The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin‐related protein. (1994) (242)
- Interleukin 6 is essential for in vivo development of B lineage neoplasms (1995) (235)
- Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line (1985) (217)
- Continuous cultures of fused cells secreting antibody of predefined specificity. 1975. (1992) (217)
- Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice. (1997) (173)
- The immune response to Plasmodium chabaudi malaria in interleukin‐4‐deficient mice (1994) (171)
- Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse. (1985) (165)
- IgD can largely substitute for loss of IgM function in B cells (1998) (155)
- Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens. (1993) (144)
- Pillars Article: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 1975, 256 (5517): 495–497. (2005) (141)
- Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. (1997) (133)
- Immunoglobulin chain loss in hybridoma lines. (1980) (116)
- Immunoglobulin M mutants (1980) (113)
- Two new proteins preferentially associated with membrane immunoglobulin D. (1994) (112)
- Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells. (1983) (112)
- Pleiotropic Defects of IL‐6—deficient Mice Including Early Hematopoiesis, T and B Cell Function, and Acute Phase Responses (1995) (99)
- A role for immunoglobulin D: interference with tolerance induction (1993) (97)
- Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line (1996) (93)
- Immunoglobulin production by lymphocyte hybridomas (1978) (92)
- Monoclonal antibodies specific for murine IgM I. Characterization of antigenic determinants on the four constant domains of the μ heavy chain (1984) (90)
- Deletions in immunoglobulin mu chains. (1982) (79)
- IgM antibodies induce the production of antibodies of the same specificity. (1980) (73)
- Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice (1987) (66)
- Characterization of a Monoclonal Anti-H-2Kb Antibody (1981) (65)
- Somatic cell genetics of antibody-secreting cells: studies of clonal diversification and analysis by cell fusion. (1977) (65)
- Molecular requirements for the mu‐induced light chain gene rearrangement in pre‐B cells. (1991) (64)
- The Nobel Lectures in Immunology (1993) (61)
- Mutations affecting the structure and function of immunoglobulin M (1982) (57)
- A second promoter and enhancer element within the immunoglobulin heavy chain locus (1994) (53)
- Derivation of hybrids between a thymoma line and spleen cells activated in a mixed leukocyte reaction (1977) (52)
- The genes for a mouse hematopoietic differentiation marker called the heat‐stable antigen (1991) (51)
- Biological activities of antitrinitrophenyl and antidinitrophenyl mouse monoclonal antibodies. (1982) (50)
- The heat stable antigen (mouse CD24) gene is differentially regulated but has a housekeeping promoter. (1993) (46)
- Frequency of precursor cells against the enzyme β‐galactosidase An estimate of the BALB/c strain antibody repertoire (1976) (46)
- 17 – The Technique of Hybridoma Production (1981) (42)
- Fusion of T and B cells (1977) (41)
- Expression, distribution and specificity of Fc receptors for IgM on murine B cells. (1988) (38)
- B cell tolerance in mice transgenic for anti-CD8 immunoglobulin mu chain (1991) (34)
- Immune status of a μ, χ transgenic mouse line. Deficient response to bacterially related antigens (1989) (34)
- The contribution of constant region domains to the binding of murine IgM to Fc mu receptors on T cells. (1988) (30)
- Cellular and molecular restrictions of the lymphocyte fusion. (1978) (28)
- A survey of protein‐DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a particularly complex pattern around the DQ52 element (1992) (26)
- Roles of protein and carbohydrate in glycoprotein processing and secretion. Studies using mutants expressing altered IgM mu chains. (1981) (26)
- Early B cell development requires μ signaling (1993) (24)
- The molecular interactions with helper T cells which limit antigen‐specific B cell differentiation (1988) (24)
- Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line. (1985) (24)
- Elimination of CD8+ thymocytes in transgenic mice expressing an anti‐Lyt2.2 immunoglobulin heavy chain gene. (1989) (23)
- B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24) (1995) (22)
- Derivation and diversification of monoclonal antibodies. (1986) (22)
- Role of c-myc and CD45 in spontaneous and anti-receptor-induced apoptosis in adult murine B cells. (1996) (21)
- Non‐tolerance and differential susceptibility to diabetes in transgenic mice expressing major histocompatibility class II genes on pancreatic β cells (1990) (19)
- Frequency of expressed immunoglobulin light chain genes in lipopolysaccharide-stimulated BALB/c spleen cells (1984) (19)
- Immunoglobulin µ and γ heavy chain classes are not determined by class-specific RNA-splicing enzymes (1978) (16)
- Non‐tolerant B cells cause autoimmunity in anti‐CD8 IgG2a‐transgenic mice (1996) (15)
- Derivation and diversification of monoclonal antibodies (1985) (15)
- Partial tolerance in β‐galactosidase‐transgenic mice (1990) (13)
- Derivation and Diversification of Monoclonal Antibodies (1993) (13)
- Transformation of B and non‐B cell lines with the 2,4,6‐ trinitrophenyl (TNP)‐specific immunoglobulin genes (1985) (13)
- Targeting cytotoxic T cells to antigen‐specific B lymphocytes (1987) (12)
- Derivation and Diversification of Monoclonal Antibodies (Nobel Lecture) (1985) (11)
- A monoclonal antibody against a new differentiation antigen of thymocytes (1983) (11)
- Expression and biological effects of high levels of serum IgE in ϵ heavy chain transgenic mice (1991) (10)
- Analysis of T-cell subpopulations in human IL-2R alpha transgenic mice: expansion of Thy1.2- thymocytes and depletion of double-positive T-cell precursors. (1989) (10)
- Monoclonal antibodies specific for murine IgM I. Characterization of antigenic determinants on the four constant domains of the mu heavy chain. (1984) (10)
- Constitutive expression of transgenic heat stable antigen (mCD24) in lymphocytes can augment a secondary antibody response. (1993) (9)
- Fusion of Lymphocytes (1979) (8)
- Early B cell development requires mu signaling. (1993) (8)
- ISOLATION AND CHARACTERIZATION OF A MOUSE‐RABBIT HYBRIDOMA (1980) (7)
- Transgenic Mouse Model for Peripheral B Cell Tolerance (1994) (6)
- Regulation of Immunoglobulin Gene Rearrangement (1989) (6)
- Immune responses in Interleukin 4-deficient mice (1994) (6)
- Resolving power of isotachophoresis and isoelectric focusing for immunoglobulins (1976) (5)
- Different ways to modify monoclonal antibodies (1984) (5)
- Partial tolerance in beta-galactosidase-transgenic mice. (1990) (5)
- The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1984. Derivation and diversification of monoclonal antibodies. (1993) (5)
- Analysis of B-cell tolerance in mice expressing transgenic anti-CD8.2 immunoglobulin M molecules. (1992) (5)
- Efficient nonhomologous and homologous recombination in scid cells (2004) (3)
- Immune status of a mu, kappa transgenic mouse line. Deficient response to bacterially related antigens. (1989) (3)
- A lacZ-based vector system for the rapid detection of V(D)J recombinase activity. (1994) (3)
- [Clonal variations of myelomatous cells (proceedings)]. (1977) (2)
- Allelic exclusion--one facet of B-cell development. (1989) (2)
- The Production of Monoclonal Antibodies by Cell Fusion (1977) (2)
- Stabilization of Conformations of E. coli ß-Galactosidase by Specific Antibodies. Restrictions in Antigenic Determinants and Antibodies (1972) (2)
- Continuous cultures of fused cells secreting antibody of predefined specificity. 1975. (2005) (1)
- Isotachophoresis of Immunoglobulins (1979) (1)
- Clonal Diversification of Antibody-Producing Cells in Culture (1977) (1)
- Sequence and structure of the mouse IgH DQ52 5′ region (2005) (1)
- Fusion of Immunoglobulin Secreting Cells (1979) (1)
- Biochemical genetics of the mouse IgM system. (1984) (1)
- Schistosoma japonicum Is Less Sensitive to Cyclosporin A In Vivo Than Schistosoma (1999) (0)
- (immune regulation/antigen-independent immune response/idiotypic network/anti-idiotypic Thelper cells) (2016) (0)
- Immunoglobulin production in transgenic mice (1986) (0)
- Mutant monoclonal antibodies. (1983) (0)
- Immunoglobulin mu and gamma heavy chain classes are not determined by class-specific RNA-splicing enzymes. (1978) (0)
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What Schools Are Affiliated With Georges J. F. Köhler?
Georges J. F. Köhler is affiliated with the following schools:
