Gabriel Núñez | Academic Influence

Gabriel Núñez 's AcademicInfluence.com Rankings

Gabriel Núñez

Biology

#3225

World Rank

#4962

Historical Rank

Immunology

#138

World Rank

#145

Historical Rank

biology Degrees

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Biology

Gabriel Núñez 's Degrees

Masters Biology Stanford University
Bachelors Biochemistry University of California, Berkeley

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Why Is Gabriel Núñez Influential?

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According to Wikipedia, Gabriel Núñez, is a Spanish molecular biologist and immunologist who is known for leading one of the first groups that identified NOD1 and NOD2, two important intracellular pattern recognition receptors. He is currently the Paul de Kruif Endowed Professor at the department of pathology at Michigan Medicine. In 2019, he was elected to the National Academy of Medicine for his many contributions to the basic sciences in the field of medicine.

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Gabriel Núñez 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease (2001) (4971)
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death (1990) (3857)
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death (1993) (3155)
Sterile inflammation: sensing and reacting to damage (2010) (2494)
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. (1997) (2401)
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (2010) (1934)
NLRP3 inflamasomes are required for atherogenesis and activated by cholesterol crystals that form early in disease (2010) (1887)
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract (2005) (1850)
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. (1999) (1730)
Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2 (2003) (1697)
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases (2015) (1657)
Role of the gut microbiota in immunity and inflammatory disease (2013) (1617)
Mechanism and Regulation of NLRP3 Inflammasome Activation. (2016) (1614)
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis (2009) (1562)
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility (2016) (1530)
K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. (2013) (1453)
Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB* (2001) (1390)
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid (2003) (1303)
bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation (1989) (1267)
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry (2010) (1251)
Control of pathogens and pathobionts by the gut microbiota (2013) (1158)
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages (2006) (1157)
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 (2006) (1150)
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes (2010) (1141)
Caspases: the proteases of the apoptotic pathway (1998) (1073)
NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. (2005) (1030)
Intracellular NOD-like receptors in host defense and disease. (2007) (996)
Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. (1990) (941)
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems (2002) (914)
Sensing and reacting to microbes through the inflammasomes (2012) (899)
The NLR gene family: a standard nomenclature. (2008) (805)
Negative Regulation of the Forkhead Transcription Factor FKHR by Akt* (1999) (800)
Function of Nod‐like receptors in microbial recognition and host defense (2009) (754)
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease (2017) (754)
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells (2015) (737)
Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux (2016) (729)
NOD-like receptors: role in innate immunity and inflammatory disease. (2009) (704)
Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA*> (2006) (698)
Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB* (1999) (691)
Cell death and immunity: NODs: intracellular proteins involved in inflammation and apoptosis (2003) (672)
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance (1999) (658)
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. (1994) (643)
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. (1998) (577)
Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides* (2001) (568)
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. (2007) (559)
Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages1 (2007) (558)
Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages (2007) (549)
Crohn's disease and the NOD2 gene: a role for paneth cells. (2003) (548)
NOD1 and NOD2: signaling, host defense, and inflammatory disease. (2014) (543)
An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. (2000) (541)
Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome (2011) (537)
Regulated Virulence Controls the Ability of a Pathogen to Compete with the Gut Microbiota (2012) (523)
DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 (2012) (501)
RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs1 (2007) (491)
Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation1 (2009) (484)
Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf* (2006) (479)
Lack of common NOD2 variants in Japanese patients with Crohn's disease. (2002) (479)
Role of cytochrome c and dATP/ATP hydrolysis in Apaf‐1‐mediated caspase‐9 activation and apoptosis (1999) (469)
Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation* (2002) (467)
NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. (2013) (466)
A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation (2008) (454)
bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. (1994) (453)
The Nlrp3 inflammasome is critical for aluminium hydroxide‐mediated IL‐1β secretion but dispensable for adjuvant activity (2008) (449)
Mechanisms of inflammation-driven bacterial dysbiosis in the gut (2016) (445)
Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-κB Signaling Pathway* (2001) (434)
Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. (2003) (420)
Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo (2010) (415)
A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis (2011) (393)
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition (2004) (376)
Interaction and Regulation of Subcellular Localization of CED-4 by CED-9 (1997) (373)
Staphylococcus δ-toxin induces allergic skin disease by activating mast cells (2013) (370)
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. (1998) (367)
Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock. (2015) (360)
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. (1997) (359)
Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria* (2007) (354)
Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2. (1996) (353)
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. (1997) (338)
A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome1 (2009) (338)
Developmental regulation of the Bcl‐2 protein and susceptibility to cell death in B lymphocytes. (1994) (326)
Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine (2012) (317)
Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. (1994) (312)
Erythropoietin Can Induce the Expression of Bcl-xLthrough Stat5 in Erythropoietin-dependent Progenitor Cell Lines* (1999) (308)
NOD-like receptors (NLRs): bona fide intracellular microbial sensors. (2008) (303)
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. (1999) (302)
bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. (1995) (300)
Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes *S (2008) (289)
NOD1 variation, immunoglobulin E and asthma. (2005) (287)
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. (2008) (286)
Critical role for Ipaf in Pseudomonas aeruginosa‐induced caspase‐1 activation (2007) (285)
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner (2017) (285)
NLRC4-driven interleukin-1β production discriminates between pathogenic and commensal bacteria and promotes host intestinal defense (2012) (283)
Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification. (1993) (277)
Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage. (2015) (275)
WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation* (1998) (272)
Nods: a family of cytosolic proteins that regulate the host response to pathogens. (2002) (261)
Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. (2016) (260)
A requirement for CARMA1 in TCR-induced NF-κB activation (2002) (257)
Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death. (1997) (256)
Intracellular NOD‐like receptors in innate immunity, infection and disease (2007) (256)
Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. (2014) (253)
The NOD: a signaling module that regulates apoptosis and host defense against pathogens (2001) (249)
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome (2019) (241)
Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF-κB Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor1 (2009) (241)
ML -- a conserved domain involved in innate immunity and lipid metabolism. (2002) (241)
RICK, a Novel Protein Kinase Containing a Caspase Recruitment Domain, Interacts with CLARP and Regulates CD95-mediated Apoptosis* (1998) (240)
Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population (1990) (239)
Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis. (1995) (239)
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. (2008) (239)
The Bcl-2 family of proteins: regulators of cell death and survival. (1994) (238)
Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells1 (2008) (236)
Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury. (2015) (230)
c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. (1994) (230)
Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. (2004) (229)
Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis. (2000) (229)
The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. (2008) (228)
Induction of Bcl-xL Expression by Human T-Cell Leukemia Virus Type 1 Tax through NF-κB in Apoptosis-Resistant T-Cell Transfectants with Tax (1999) (227)
The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. (2011) (227)
Bcl-2 maintains B cell memory (1991) (221)
Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis. (1995) (220)
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo (2006) (215)
Regulation of the immune system by the resident intestinal bacteria. (2014) (213)
Host–microbiota interactions in inflammatory bowel disease (2020) (209)
ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells. (1999) (206)
Caspase‐1 inflammasomes in infection and inflammation (2007) (204)
Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene. (1997) (201)
bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice (1996) (201)
Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. (2011) (200)
Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice (1995) (199)
Nucleotide-binding Oligomerization Domain-1 and Epidermal Growth Factor Receptor (2006) (195)
Bimp1, a MAGUK Family Member Linking Protein Kinase C Activation to Bcl10-mediated NF-κB Induction* (2001) (195)
ASC is an activating adaptor for NF-κB and caspase-8-dependent apoptosis (2003) (195)
Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes1 (2006) (191)
3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome* (2013) (185)
Nod1/RICK and TLR Signaling Regulate Chemokine and Antimicrobial Innate Immune Responses in Mesothelial Cells1 (2007) (182)
CARMA3/Bcl10/MALT1-dependent NF-κB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells (2007) (181)
Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell Death* (1998) (178)
TLR Agonists Stimulate Nlrp3-Dependent IL-1β Production Independently of the Purinergic P2X7 Receptor in Dendritic Cells and In Vivo (2013) (171)
Nucleotide-Binding Oligomerization Domain 1 Mediates Recognition of Clostridium difficile and Induces Neutrophil Recruitment and Protection against the Pathogen (2011) (168)
Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod21 (2008) (168)
Differential Release and Distribution of Nod1 and Nod2 Immunostimulatory Molecules among Bacterial Species and Environments* (2006) (166)
Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance. (2002) (164)
MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction (2013) (164)
Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death. (2000) (162)
A Role for Erbin in the Regulation of Nod2-dependent NF-κB Signaling* (2005) (162)
Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens (2017) (162)
Peptidoglycan Signaling in Innate Immunity and Inflammatory Disease* (2005) (160)
Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2. (2013) (158)
Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival. (1994) (158)
Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. (2003) (158)
CIPER, a Novel NF κB-activating Protein Containing a Caspase Recruitment Domain with Homology to Herpesvirus-2 Protein E10* (1999) (158)
P2X7 Receptor-Stimulated Secretion of MHC Class II-Containing Exosomes Requires the ASC/NLRP3 Inflammasome but Is Independent of Caspase-1 1 (2009) (156)
Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo. (1995) (155)
Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. (2010) (154)
bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation. (1993) (154)
Nucleotide-Binding Oligomerization Domain-Like Receptors: Intracellular Pattern Recognition Molecules for Pathogen Detection and Host Defense1 (2006) (152)
Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation. (2017) (151)
Interaction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9* (1997) (144)
Programmed cell death by bcl‐2‐dependent and independent mechanisms in B lymphoma cells. (1993) (142)
CARD15 mutations in familial granulomatosis syndromes: a study of the original Blau syndrome kindred and other families with large-vessel arteritis and cranial neuropathy. (2002) (142)
Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells. (1989) (141)
The interplay between host immune cells and gut microbiota in chronic inflammatory diseases (2017) (139)
The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection (2018) (139)
Interleukin-10 ablation promotes tumor development, growth, and metastasis. (2012) (138)
Inflammasomes in intestinal inflammation and cancer. (2011) (136)
A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells. (1995) (136)
Clathrin- and Dynamin-Dependent Endocytic Pathway Regulates Muramyl Dipeptide Internalization and NOD2 Activation1 (2009) (135)
Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL * (1998) (133)
Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria (2009) (133)
Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL. (1996) (132)
Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling. (2014) (131)
NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages (2011) (129)
Inflammasomes as microbial sensors (2010) (127)
The Nod-Like Receptor Family Member Naip5/Birc1e Restricts Legionella pneumophila Growth Independently of Caspase-1 Activation1 (2007) (126)
Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux (2014) (126)
Bcl-XL protects cancer cells from p53-mediated apoptosis. (1995) (126)
TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation* (2011) (126)
Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt (1999) (126)
Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri. (2007) (124)
The NOD2-RICK Complex Signals from the Plasma Membrane* (2007) (123)
The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL‐1β production in Helicobacter pylori infected dendritic cells (2013) (121)
EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL (1998) (121)
Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF-κB Signaling (2010) (121)
Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage. (2014) (121)
Cholesterol‐dependent cytolysins induce rapid release of mature IL‐1β from murine macrophages in a NLRP3 inflammasome and cathepsin B‐dependent manner (2009) (121)
A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni (2007) (120)
Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. (2011) (120)
Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide (1998) (119)
Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines. (2005) (119)
Role of the Gut Microbiota in the Development and Function of Lymphoid Cells (2013) (119)
A requirement for CARMA1 in TCR-induced NF-kappa B activation. (2002) (117)
A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. (2005) (116)
Respiratory Virus-Induced TLR7 Activation Controls IL-17–Associated Increased Mucus via IL-23 Regulation (2010) (116)
Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies. (1998) (115)
v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells. (1994) (115)
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity (2016) (115)
Caenorhabditis elegans EGL-1 Disrupts the Interaction of CED-9 with CED-4 and Promotes CED-3 Activation* (1998) (114)
RNase L activates the NLRP3 inflammasome during viral infections. (2015) (113)
Structural mechanism for NEK7-licensed NLRP3 inflammasome activation (2019) (113)
Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity. (2013) (112)
Modulation of anti-IgM-induced B cell apoptosis by Bcl-xL and CD40 in WEHI-231 cells. Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction. (1995) (111)
Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination. (2015) (110)
A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. (2013) (109)
Protective Role of Commensals against Clostridium difficile Infection via an IL-1β–Mediated Positive-Feedback Loop (2012) (109)
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. (2003) (109)
Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival. (1994) (107)
Bcl-2 orchestrates a cross-talk between endothelial and tumor cells that promotes tumor growth. (2007) (106)
Caspy, a Zebrafish Caspase, Activated by ASC Oligomerization Is Required for Pharyngeal Arch Development* (2003) (106)
Genes with homology to mammalian apoptosis regulators identified in zebrafish (2000) (105)
Expression and Functional Analysis of Apaf-1 Isoforms (2000) (105)
TLR4-Mediated AKT Activation Is MyD88/TRIF Dependent and Critical for Induction of Oxidative Phosphorylation and Mitochondrial Transcription Factor A in Murine Macrophages (2012) (105)
Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells. (1995) (105)
Bax Can Antagonize Bcl-XL during Etoposide and Cisplatin-induced Cell Death Independently of Its Heterodimerization with Bcl-XL* (1996) (103)
Linking extracellular survival signals and the apoptotic machinery (1998) (102)
Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis. (2019) (102)
DICER 1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP 3 Inflammasome and MyD 88 (2012) (100)
Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal. (1997) (99)
Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. (1996) (98)
Bcl-x protects primary B cells against Fas-mediated apoptosis. (1997) (96)
Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation* (2011) (94)
T cell intrinsic role of Nod2 in promoting type I immunity against Toxoplasma gondii (2009) (93)
Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ (2014) (92)
Sarcoidosis and NOD1 variation with impaired recognition of intracellular Propionibacterium acnes. (2006) (92)
Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis (2013) (92)
IKKα negatively regulates ASC-dependent inflammasome activation (2014) (91)
Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury. (2013) (91)
PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. (2009) (91)
Critical Role for DP5/Harakiri, a Bcl-2 Homology Domain 3-Only Bcl-2 Family Member, in Axotomy-Induced Neuronal Cell Death (2004) (90)
The protein kinase PKR is critical for LPS‐induced iNOS production but dispensable for inflammasome activation in macrophages (2013) (90)
TAK1 Is a Central Mediator of NOD2 Signaling in Epidermal Cells* (2008) (90)
Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein. (2012) (89)
Constitutive expression of Bcl‐xL or Bcl‐2 prevents peptide antigen‐induced T cell deletion but does not influence T cell homeostasis after a viral infection (1998) (89)
Bcl-xL is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis. (1998) (88)
Staphylococcus δ-toxin promotes mouse allergic skin disease by inducing mast cell degranulation (2013) (88)
The TLR2‐MyD88‐NOD2‐RIPK2 signalling axis regulates a balanced pro‐inflammatory and IL‐10‐mediated anti‐inflammatory cytokine response to Gram‐positive cell walls (2008) (87)
Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages (2014) (86)
Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin (2016) (85)
Transgene Expression of bcl-xL Permits Anti-immunoglobulin (Ig)–induced Proliferation in xid B Cells (1998) (85)
TLR3 Increases Disease Morbidity and Mortality from Vaccinia Infection1 (2008) (85)
Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome. (2014) (84)
Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model. (1999) (83)
Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. (2007) (82)
Microbial metabolite sensor GPR43 controls severity of experimental GVHD (2018) (81)
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity (2009) (80)
Dendritic Cell-specific MHC Class II Transactivator Contains a Caspase Recruitment Domain That Confers Potent Transactivation Activity* (2001) (77)
Kaposi's sarcoma tumor cells preferentially express Bcl-xL. (1996) (77)
A Dual Role for Receptor-interacting Protein Kinase 2 (RIP2) Kinase Activity in Nucleotide-binding Oligomerization Domain 2 (NOD2)-dependent Autophagy* (2012) (77)
The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation. (2011) (76)
Role of the microbiota in skin immunity and atopic dermatitis. (2017) (76)
IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections (2017) (75)
Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. (2000) (74)
Apoptosome formation and caspase activation: is it different in the heart? (2004) (72)
A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-κB Signaling Pathways (2013) (71)
Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome (2010) (71)
NF-κB signaling in lymphocytes: a new cast of characters (2004) (70)
NOD 2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer (2013) (69)
Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells. (2000) (68)
Innate Nutritional Immunity (2018) (67)
Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome. (2015) (66)
Tumor necrosis factor alpha induces BID cleavage and bypasses antiapoptotic signals in prostate cancer LNCaP cells. (2001) (65)
A specific gene-microbe interaction drives the development of Crohn’s disease–like colitis in mice (2019) (65)
Both TNF receptors are required for direct TNF‐mediated cytotoxicity in microvascular endothelial cells (1998) (64)
A Novel Caspase-1/Toll-like Receptor 4-independent Pathway of Cell Death Induced by Cytosolic Shigella in Infected Macrophages* (2005) (63)
Apoptosis in keratinocytes is not dependent on induction of differentiation. (1997) (62)
ATG16L1 deficiency in macrophages drives clearance of Uropathogenic E. coli in an IL-1β dependent manner (2015) (61)
Intestinal macrophages arising from CCR2+ monocytes control pathogen infection by activating innate lymphoid cells (2015) (61)
Enforced expression of Bcl-XS induces differentiation and sensitizes chronic myelogenous leukemia-blast crisis K562 cells to 1-beta-D-arabinofuranosylcytosine-mediated differentiation and apoptosis. (1996) (60)
Embryonic loss due to exposure to polycyclic aromatic hydrocarbons is mediated by Bax (2006) (59)
Protective Effect of Toll-like Receptor 4 in Pulmonary Vaccinia Infection (2008) (57)
Bak can accelerate chemotherapy-induced cell death independently of its heterodimerization with Bcl-XL and Bcl-2 (1997) (57)
Dysregulation of p38 and MKP-1 in response to NOD1/TLR4 stimulation in sarcoid bronchoalveolar cells. (2011) (57)
Lack of association between NOD2 3020InsC frameshift mutation and psoriasis. (2001) (56)
NF-kappaB signaling in lymphocytes: a new cast of characters. (2004) (55)
Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn's disease. (2003) (55)
Nod2 and Rip2 contribute to innate immune responses in mouse neutrophils (2014) (55)
Bcl-2: B cell life, death and neoplasia. (1990) (55)
Regulation of Bcl-xl Channel Activity by Calcium* (1998) (54)
Fatal Acute Lymphoblastic Leukemia in Mice Transgenic for B Cell-Restricted bcl-xL and c-myc1 (2004) (54)
Dynamic and Asymmetric Changes of the Microbial Communities after Cohousing in Laboratory Mice. (2019) (54)
Crystal structure of the Nod1 caspase activation and recruitment domain. (2007) (53)
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response (2019) (52)
Mechanism of Impaired NLRP3 Inflammasome Priming by Monophosphoryl Lipid A (2011) (52)
Cutting Edge: Crohn’s Disease-Associated Nod2 Mutation Limits Production of Proinflammatory Cytokines To Protect the Host from Enterococcus faecalis-Induced Lethality (2011) (52)
Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice. (2019) (52)
Orchestrating Inflammasomes (2012) (51)
Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk. (2019) (50)
Élie Metchnikoff (1845–1916): celebrating 100 years of cellular immunology and beyond (2016) (47)
A Role of Lipophilic Peptidoglycan-related Molecules in Induction of Nod1-mediated Immune Responses* (2007) (47)
Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice (2013) (47)
A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells. (2017) (47)
Transitions in Oral and Intestinal Microflora Composition and Innate Immune Receptor-Dependent Stimulation during Mouse Development (2009) (47)
Ablation of microvessels in vivo upon dimerization of iCaspase-9 (2002) (47)
Erratum: RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates cd95-mediated apoptosis (Journal of Biological Chemistry (1998) 273 (12296-12300)) (1998) (47)
C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death. (1999) (47)
Protein Kinase C-associated Kinase (PKK) Mediates Bcl10-independent NF-κB Activation Induced by Phorbol Ester* (2002) (46)
Roles for Homotypic Interactions and Transautophosphorylation in IκB Kinase (IKKβ) Activation* (2003) (46)
Unidirectional crosstalk between Bcl-xL and Bcl-2 enhances the angiogenic phenotype of endothelial cells (2007) (46)
Cross-Tolerization between Nod1 and Nod2 Signaling Results in Reduced Refractoriness to Bacterial Infection in Nod2-Deficient Macrophages1 (2008) (44)
A role for Nod-like receptors in autophagy induced by Shigella infection (2008) (44)
A Genome-wide Small Interfering RNA (siRNA) Screen Reveals Nuclear Factor-κB (NF-κB)-independent Regulators of NOD2-induced Interleukin-8 (IL-8) Secretion* (2014) (43)
Constitutive expression of bcl-2 in B cells causes a lethal form of lupuslike autoimmune disease after induction of neonatal tolerance to H- 2b alloantigens (1996) (43)
An Induced Proximity Model for NF- κ B Activation in the Nod1/RICK and RIP Signaling Pathways (2000) (42)
Rosmarinus officinalis L. (Rosemary) Extracts Containing Carnosic Acid and Carnosol are Potent Quorum Sensing Inhibitors of Staphylococcus aureus Virulence (2020) (42)
A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death. (1996) (41)
Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn’s disease (2018) (41)
P-Selectin Glycoprotein Ligand-1 Regulates Adhesive Properties of the Endothelium and Leukocyte Trafficking Into Adipose Tissue (2010) (40)
Expression and Functional Analysis of Apaf-1 Isoforms EXTRA WD-40 REPEAT IS REQUIRED FOR CYTOCHROME c BINDING AND REGULATED ACTIVATION OF PROCASPASE-9* (2000) (40)
Evolutionary comparison of murine and human delta T-cell receptor deleting elements. (1989) (39)
Altered expression of mRNAs for apoptosis‐modulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdr1 mRNA (1999) (39)
Age-dependent injury in human umbilical vein endothelial cells: relationship to apoptosis and correlation with a lack of A20 expression. (1995) (39)
Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development (2020) (38)
Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2 (1996) (38)
IL-18 is not therapeutic for neovascular age-related macular degeneration (2014) (37)
Evaluation of a new dual-specificity promoter for selective induction of apoptosis in breast cancer cells (2001) (37)
Interruption of Macrophage-Derived IL-27(p28) Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3 (2014) (37)
Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL‐1β (2019) (37)
Bacterial RNA Mediates Activation of Caspase-1 and IL-1β Release Independently of TLRs 3, 7, 9 and TRIF but Is Dependent on UNC93B (2012) (35)
Membrane Damage during Listeria monocytogenes Infection Triggers a Caspase-7 Dependent Cytoprotective Response (2012) (34)
TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen. (2014) (34)
Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death. (1995) (33)
Nod1/Nod2-Mediated Recognition Plays a Critical Role in Induction of Adaptive Immunity to Anthrax after Aerosol Exposure (2009) (33)
Influence of donor microbiota on the severity of experimental graft-versus-host-disease. (2013) (33)
A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni (2007) (33)
Identification and functional characterization of EseH, a new effector of the type III secretion system of Edwardsiella piscicida (2017) (33)
MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. (2006) (33)
Innate immune recognition of flagellin limits systemic persistence of Brucella (2013) (33)
Receptor-interacting Protein Shuttles between Cell Death and Survival Signaling Pathways (2010) (33)
Antiangiogenic gene therapy: disruption of neovascular networks mediated by inducible caspase-9 delivered with a transcriptionally targeted adenoviral vector (2005) (32)
The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. (2012) (32)
E1B 19,000-Molecular-Weight Protein Interacts with and Inhibits CED-4-Dependent, FLICE-Mediated Apoptosis (1998) (32)
Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling (2018) (32)
Extended haplotype association study in Crohn’s disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-κB pathway gene, HEATR3 (2013) (32)
G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy (2021) (30)
Divergence of the systemic immune response following oral infection with distinct strains of Porphyromonas gingivalis. (2012) (30)
Stromal cells regulate bcl-2 and bax expression in pro-B cells. (1996) (29)
Induction of Pulmonary Granuloma Formation by Propionibacterium acnes Is Regulated by MyD88 and Nox2 (2017) (29)
Functional expression of the intracellular pattern recognition receptor NOD1 in human keratinocytes. (2009) (28)
Increase in Bcl-2 level promoted by CD40 ligation correlates with inhibition of B cell apoptosis induced by vacuolar type H(+)-ATPase inhibitor. (1998) (28)
Physiological cell death in B lymphocytes: I. Differential susceptibility of WEHI-231 sublines to anti-Ig induced physiological cell death and lack of correlation with bcl-2 expression. (1994) (28)
Genes with homology to DFF/CIDEs found in Drosophila melanogaster. (1999) (27)
Role of NOD1 in Heart Failure Progression via Regulation of Ca2+ Handling. (2017) (27)
Peptidoglycan Recognition Protein 3 and Nod2 Synergistically Protect Mice from Dextran Sodium Sulfate–Induced Colitis (2014) (27)
RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly. (2020) (26)
Level of endothelial cell apoptosis required for a significant decrease in microvessel density. (2007) (26)
SLC15A2 and SLC15A4 Mediate the Transport of Bacterially Derived Di/Tripeptides To Enhance the Nucleotide-Binding Oligomerization Domain–Dependent Immune Response in Mouse Bone Marrow–Derived Macrophages (2018) (26)
NOD1, a new player in cardiac function and calcium handling. (2015) (26)
Role of nucleotide‐binding oligomerization domain 1 (NOD1) in pericyte‐mediated vascular inflammation (2016) (24)
Prdx4 limits caspase‐1 activation and restricts inflammasome‐mediated signaling by extracellular vesicles (2019) (24)
Redundant and Cooperative Interactions between TLR5 and NLRC4 in Protective Lung Mucosal Immunity against Pseudomonas aeruginosa (2014) (24)
Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease (2018) (24)
Battling enteroinvasive bacteria: Nod1 comes to the rescue. (2004) (23)
Multiple effects of dendritic cell depletion on murine norovirus infection. (2013) (23)
Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice (2011) (22)
A complex microworld in the gut: Harnessing pathogen-commensal relations (2012) (22)
Selective Biological Responses of Phagocytes and Lungs to Purified Histones (2017) (21)
TLR4: The Winding Road to the Discovery of the LPS Receptor (2016) (21)
RICK Promotes Inflammation and Lethality after Gram-Negative Bacterial Infection in Mice Stimulated with Lipopolysaccharide (2009) (21)
Intracellular sensors of microbes and danger (2011) (21)
Pathogen Colonization Resistance in the Gut and Its Manipulation for Improved Health. (2019) (21)
NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice. (2011) (20)
Gut microbiota and systemic immunity in health and disease. (2020) (19)
Regulation of lymphoid apoptosis by Bcl-2 and Bcl-XL. (1996) (19)
Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation (2016) (18)
Gut Immunity: A NOD to the Commensals (2009) (18)
Calcium-Independent Phospholipase A2β Is Dispensable in Inflammasome Activation and Its Inhibition by Bromoenol Lactone (2009) (18)
Loss of NLRP6 expression increases the severity of acute kidney injury. (2019) (18)
Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells (2008) (17)
Suppression activity of pro-apoptotic gene products in cancer cells, a potential application for cancer gene therapy. (2001) (17)
An Enteric Pathogen Subverts Colonization Resistance by Evading Competition for Amino Acids in the Gut. (2020) (17)
Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. (2003) (14)
Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions. (2012) (13)
A small molecule inhibitior of the NLRP 3 inflammasome is a potential therapeutic for inflammatory diseases (2015) (13)
Killing of sarcoma cells by proapoptotic Bcl-X(S): role of the BH3 domain and regulation by Bcl-X(L). (2001) (13)
Targeting cancer cell death with a bcl-xS adenovirus (2004) (12)
NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome (2017) (11)
Cryopyrin-induced Interleukin 1β Secretion in Monocytic Cells (2004) (11)
Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria (2009) (10)
AIM2 joins the gang of microbial sensors. (2010) (9)
Recognition of the microbiota by Nod2 contributes to the oral adjuvant activity of cholera toxin through the induction of interleukin‐1β (2019) (9)
Interaction between Staphylococcus Agr virulence and neutrophils regulates pathogen expansion in the skin. (2021) (9)
A putative role for human BFK in DNA damage-induced apoptosis. (2009) (9)
Lipopolysaccharide O structure of adherent and invasive Escherichia coli regulates intestinal inflammation via complement C3 (2020) (9)
Altering the Microbiome Inhibits Tumorigenesis in a Mouse Model of Oviductal High-Grade Serous Carcinoma (2021) (9)
In vivo mapping of a protective linear neutralizing epitope at the N-terminus of alpha hemolysin from Staphylococcus aureus. (2014) (9)
Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis. (2021) (9)
Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S (2015) (9)
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity (2022) (8)
Mindin the fort (2004) (8)
Interaction between smoking and ATG 16 L 1 T 300 A triggers Paneth cell defects in Crohn ’ s disease (2018) (7)
A new twist on the PYRIN Mediterranean coast. (2011) (7)
The Genomic Sequence of the Oral Pathobiont Strain NI1060 Reveals Unique Strategies for Bacterial Competition and Pathogenicity (2016) (7)
A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1 (2021) (6)
Are heat shock proteins DAMPs? (2011) (6)
NLRP3-Inflammasome Inhibition during Respiratory Virus Infection Abrogates Lung Immunopathology and Long-Term Airway Disease Development (2021) (6)
Regulation of Citrobacter rodentium colonization: virulence, immune response and microbiota interactions. (2021) (6)
TUMOR NECROSIS FACTOR- α AND INTERFERON- γ INDUCE PANCREATIC β -CELL APOPTOSIS THROUGH STAT1-MEDIATED BIM ACTIVATION (2011) (5)
Inhibits Cytochrome c Release From Mitochondria and Protects Against Hypoxia-Induced Apoptosis in Heart-Derived H 9 c 2 Cells (1999) (5)
65 BCL-XS adenovirus-mediated gene therapy approach sensitizes cancer cells to radiation-induced apoptosis (1996) (5)
Immune Responses in Mesothelial Cells Chemokine and Antimicrobial Innate Nod 1 / RICK and TLR Signaling Regulate (2007) (5)
1 Interleukin ( IL )-10 ablation promotes tumor development , growth and metastasis (2011) (4)
Keratinocyte IL-36 receptor/MyD88 signaling mediates Malassezia-induced IL-17-dependent skin inflammation. (2021) (4)
Mesenchymal Cell–Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes (2017) (4)
to stimulate chemokine production and neutrophil recruitment in vivo (2006) (4)
Corrigendum: Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin (2016) (4)
Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion. (2022) (3)
Linking Pathogen Virulence, Host Immunity and The Microbiota at the Intestinal Barrier. (2017) (3)
Caspase-1 Activation Growth Independently of pneumophila Legionella Naip 5 / Birc 1 e Restricts The Nod-Like Receptor Family Member (2007) (3)
P2X7 Receptor‐dependent Secretion of IL‐1beta is Mediated by Exocytosis of Secretory Lysosomes (2007) (3)
G-CSF Secreted by Epigenetically Reprogrammed Mutant IDH1 Glioma Stem Cells Reverses the Myeloid Cells’-Mediated Immunosuppressive Tumor Microenvironment (2020) (3)
CD95 (APO-1/Fas)- and p53-independent apoptosis by betulinic acid involves mitochondrial alterations and activation of caspases. (1997) (2)
A New Twist in the Regulation of Legionella Replication through ASC and Caspase-1 (2011) (2)
Correction to Supporting Information for Conos et al., Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner (2017) (2)
Early-onset sarcoidosis gets the nod (2005) (2)
Dysregulation of Cytosolic c-di-GMP in Edwardsiella piscicida Promotes Cellular Non-Canonical Ferroptosis (2022) (2)
Epidermal clearance of Candida albicans is mediated by IL-17 but independent of fungal innate immune receptors. (2022) (2)
TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA (2021) (2)
Listeria Toxin Promotes Phosphorylation of the Inflammasome Adaptor ASC Through Lyn and Syk to Exacerbate Pathogen Expansion (2021) (2)
Understanding the microbiota in the midst of Renaissance architecture and olive groves (2013) (2)
Internalization and NOD 2 Activation Pathway Regulates Muramyl Dipeptide Clathrin-and Dynamin-Dependent Endocytic (2009) (2)
Inhibition of B‐cell death does not restore T‐cell‐dependent immune responses in CD40‐deficient mice (2003) (2)
Letter to the Editor (1999) (1)
Science Signaling Podcast: 15 January 2013 (2013) (1)
Distinct Commensals Indu ce Interleukin-1 b via NLRP 3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury Graphical Abstract Highlights (1)
Site-specific adaptation mechanisms of an oral pathobiont in the oral and gut mucosae (2022) (1)
Cytosolic Recognition of Intracellular Bacteria by ASC and Ipaf Overcomes Endotoxin Tolerance Through Induction of Potent IL-1&bgr; Secretion (2006) (1)
Natural IgA and TNFRSF13B polymorphism: a double edged sword fueling balancing selection (2021) (1)
Corrigendum to “Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome” [Int. J. Med. Microbiol. 304 (3–4) (2014) 384–392] (2015) (1)
MyD88: A Critical Adaptor Protein in Innate (2013) (1)
Mechanism of Immunostimulating Action of Peptidoglycan, Investigation with Synthetic Partial Structures (2005) (1)
Inflammasome-Induced Activation of the Nlrp 3 Staphylococcus aureus Lipoproteins in A Critical Role for Hemolysins and Bacterial (2009) (1)
IL-22 Controls Heme-Dependent Nutritional Immunity Against Systemic Bacterial Infection (2017) (1)
NOD1 Engagement Leads to Increased IL12/IL23 p40 and decreased IL-10 Expressions in Sarcoidosis as Compared to Healthy Subjects (98.17) (2009) (1)
Regulation of granuloma formation via Myd88 and Nox2 in a model of pulmonary sarcoidosis (MPF5P.741) (2015) (1)
Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen (2021) (1)
Staphylococcus PSMα induces IL-17-dependent skin inflammation through IL-36 and IL-1 secretion from keratinocytes (2017) (1)
NLRP3 inflammasome-dependent HMGB1 release induced by a bacterial pore-forming toxin (136.15) (2010) (1)
Production Alters Their Colitogenic and Suppressive Potential (2017) (0)
RICK/RIP2 Promotes Inflammation and Lethality after Gram-Negative Bacterial Infection in Mice Stimulated with Lipopolysaccharide (45.4) (2009) (0)
Genes and pathways in inflammatory diseases (SY6-5) Chairpersons: Kouji Matsushima, Virginia Pascual (2010) (0)
Loss of NLRP6 expression increases the severity of kidney injury. (2018) (0)
A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in mediating host bactericidal activity against Campylobacter jejuni (2007) (0)
Role of the APAf-1Caspase-9 Pathway in Breast Tumor Development (2002) (0)
NOD2 Activation Promotes Anti-inflammatory Activity of Human Mesenchymal Stem Cells by Prolonged PGE2 Production via NOD2-RIP2 Pathway In Vitro and in vivo (2014) (0)
A direct, bioluminescent caspase-1 assay for monitoring inflammasome activation (2016) (0)
360 CAD, a Nucleotide Synthesis Enzyme, Inhibits NOD2 Anti-Bacterial Function in Human Intestinal Epithelial Cells (2012) (0)
487 IL-36R-signaling promotes Staphylococcus aureus-induced atopic dermatitis-like skin inflammation (2016) (0)
Inflammasome (WS-078) Chairpersons: Shun'ichiro Taniguchi, Takashi Suda (2010) (0)
Regulation of Intestinal Immunity by Nod-like Receptors and the Microbiota (2012) (0)
Correction: MyD88: A critical adaptor protein in innate immunity signal transduction (2013) (0)
P063 INTERACTIONS OF GENETIC AND ENVIRONMENTAL FACTORS TRIGGER UNIQUE PPAR-GAMMA SIGNATURE IN PANETH CELLS IN CROHN’S DISEASE SUBJECTS AND RELEVANT MOUSE MODELS (2018) (0)
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome (2019) (0)
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response (2019) (0)
the effect of environmental factors in a genetically predisposed host. In the May 31 Nature, two independent research groups report on the identification of a mutation that increases susceptibility to (2001) (0)
Molecular Interactions of Bc1-2 Family Members in Breast Cancer Cells (1997) (0)
Macrophages to Bacterial Infection in Nod 2-Deficient Signaling Results in Reduced Refractoriness Cross-Tolerization between Nod 1 and Nod 2 (2008) (0)
The activation of the NLRC4 inflammasome by pathogenic bacteria breaks intestinal phagocytic cells anergy and promotes host defense: P-181. (2011) (0)
Advances in Brief Overexpression of Bcl-xs Sensitizes MCF-7 Cells to Chemotherapy-induced Apoptosis 1 (2006) (0)
Host–microbiota interactions in inflammatory bowel disease (2020) (0)
Detection and Host Defense Pattern Recognition Molecules for Pathogen Domain-Like Receptors: Intracellular Nucleotide-Binding Oligomerization (2006) (0)
I. Ediciones y técnica filológica – II. Lingüística – III. Literatura, historia y filosofía – IV. Reseñas breves (1977) (0)
Role of the Bcl-2 Proto-Oncogene in Neoplasia (1989) (0)
Expression ability of RNAIII encoding δ-toxin in S. aureus isolated from infant skin is associated with atopic dermatitis development (2016) (0)
624 PSMα as a key virulence in Staphylococcus aureus-induced skin inflammation through IL-36 and IL-1 release from keratinocytes (2017) (0)
DIETARY FIBER DEPRIVATION QUELLS COLONIC INFLAMMATION BY TARGETING GUT PATHOBIONTS IN A NEW MODEL OF CROHN’S DISEASE (2021) (0)
Erratum: P-Selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue (Circulation Research (2010) 107 (388-397)) (2010) (0)
Microbial metabolite sensor GPR43 controls severity of experimental GVHD (2016) (0)
Inflammasome in the Absence of Microbial to ATP and Silica via the NLRP 3 Mediates Sensitization α Cutting Edge : TNF - (2009) (0)
Monophosphate Lipid A's TRIF-biased TLR4 signaling results in weak NLRP3 inflammasome priming and reduced IL1beta production, leading to decreased inflammation in vivo compared to Lipid A. (136.38) (2010) (0)
A trade-off between resistance to infection and reproduction in primate evolution (2020) (0)
NOD-like receptors in innate immunity and inflammatory disease (2009) (0)
Inflammation and Tumorigenesis A Functional Role for Nlrp6 in Intestinal (0)
S1748 Effect of Genetic Background on Susceptibility to Peptidoglycan-Induced Intestinal Fibrosis in Mice (2010) (0)
On the multiple role of NLRP3 on the pathogenesis of the viral infection (INM8P.444) (2014) (0)
bcl-2 Protects SK-N-SH Cells From 6-Hydroxydopamine Induced Apoptosis by Inhibition of Cytochrome c Redistribution (2000) (0)
Activation Extracellular Signal-regulated Kinase via Listeria monocytogenes Autophagy of TLR 2 and RIP 2 Pathways Mediate Immunology : (2011) (0)
120 DIETARY INTERVENTION INHIBITS COLONIC INFLAMMATION BY TARGETING PATHOBIONTS IN A NEW MODEL OF CROHN'S DISEASE (2020) (0)
Independently of Nod 2 Activation via Cryopyrin / NLRP 3 of Muramyl Dipeptide Induces Caspase-1 Pannexin-1-Mediated Intracellular Delivery (2008) (0)
The role of NOD1 as major pattern recognition receptor for detection of Campylobacter jejuni by the intestinal epithelia (2009) (0)
Roles of innate immunity in radiation-induced intestinal injury (2015) (0)
629 Staphylococcus aureus drives atopic dermatitis-like skin inflammation via IL-36-induced IL-17 responses (2017) (0)
B and CXC Chemokines κ Nuclear Factor-Bcl-2 Acts in a Proangiogenic Signaling Pathway through (2005) (0)
Development : Paleobotany at the High Table of Evo – Devo (2016) (0)
543 Tissue-resident macrophages are controlled by mast cells via a newly identified c-Kit+CD11b+ progenitor cell (2017) (0)
Cigarette Smoking Triggers Paneth Cell Defect in Crohn's Disease Patients and Mice Harboring Susceptibility Allele ATG16L1 T300A (2017) (0)
Detection Defense Pattern Recognition Molecules for Pathogen Domain-Like Receptors: Intracellular Nucleotide-Binding Oligomerization (2006) (0)
Rack1 is essential for activation of the Nlrp3 inflammasome (2020) (0)
Cathepsin B activity is required for NALP3-induced caspase-1 activation, lysosomal dysfunction and cell death in macrophages. (135.81) (2009) (0)
A BCL-X-s adenovirus vector to selectively kill cancer cells derived from epithelial tissues (1996) (0)
Abstract 532: Nod1 functions in T cells to suppress inflammation-associated colorectal cancer (2012) (0)
and Protection against the Pathogen and Induces Neutrophil Recruitment difficile Clostridium 1 Mediates Recognition of Nucleotide-Binding Oligomerization Domain (2011) (0)
IMMU-26. TLR7 ACTIVATION IS ESSENTIAL FOR NK CELLS TO ELIMINATE GLIOMA TUMORS (2017) (0)
Mortality from Vaccinia Infection TLR3 Increases Disease Morbidity and (0)
Genetics Defects and Chronic Inflammation: How Do We Make the Connection in IBD? (2006) (0)
LB765 Whole-genome sequence of S. aureus strains from infant skin – its utility to discover bacterial target to control atopic dermatitis onset in childhood (2016) (0)
Monocytes via Inflammatory Typhimurium Salmonella Promotes Systemic Dissemination of Specific MyD 88 Signaling − Mesenchymal Cell (2017) (0)
Human delta T cell receptor: rearrangement, deletion, and translocation. (1988) (0)
Gut microbiota-reactive IgG regulates gut microbiota development and immunity against enteric pathogens in early life (2022) (0)
A major role for intestinal epithelial nucleotide oligomerization domain (NOD) protein NOD1 in mediating host bactericidal activity against Campylobacter jejuni (2007) (0)
P-241 Smoking Induces Paneth Cell Defect in Genetically Susceptible Crohn's Disease (2017) (0)
NLRP3 inflammasome participates in lysosomal destabilization in macrophages exposed to the bacterial toxin tetanolysin O (136.30) (2010) (0)
TRIF but Is Dependent Release Independently β Caspase-1 and IL-1 Bacterial RNA Mediates Activation of Núñez and Alexander Dalpke (2012) (0)
Abstract 1319: Monitoring inflammasome activation with a bioluminescent caspase-1 assay (2015) (0)
Iron Toxicity in the Retina Requires Alu RNA and the NLRP 3 Inflammasome Graphical Abstract Highlights (2018) (0)
Cooperation of IL-1 and IL-36 plays a pivotal role in epicutaneous S. aureus-induced skin inflammation via IL-17 production (2016) (0)
623 Cutaneous acquisition of Staphylococcus quorum-sensing agr mutations protects against atopic dermatitis development (2017) (0)
Efflux + and K MAVS-Induced Membrane Permeabilization the NLRP3 Inflammasome via Cytosolic Double-Stranded RNA Activates (2014) (0)
Toll-like receptors, session 1 (WS-001a) Chairpersons: Kensuke Miyake, Hermann Wagner (2010) (0)
MCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel potential therapeutic for NLRP3 driven diseases (2014) (0)
24 A SPECIFIC GENE-MICROBE INTERACTION DRIVES THE DEVELOPMENT OF EARLY-ONSET CROHN’S DISEASE-LIKE COLITIS (2019) (0)
Signaling Pathways A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of (2013) (0)
In Vivo Purinergic P 2 X 7 Receptor in Dendritic Cells Production Independently of the β IL-1 TLR Agonists Stimulate Nlrp 3-Dependent (2012) (0)
Molecular Analysis of Bcl-xS-Induced Apoptosis in Breast Cancer (1997) (0)
S1189 NOD2 Gene Mutations Predict CT Enterography-Defined Strictures (2009) (0)
Domain-Mediated NF-TLR / Nucleotide-Binding Oligomerization Inflammasome via Cytotoxins and Activate NLRP 3 Vibrio Pathogenic (2010) (0)
Maternal smoking during pregnancy is associated with a variety of adverse neonatal outcomes including altered reproductive performance (2007) (0)
Cooperative Roles Of TLR5 And Ipaf In Murine Pseudomonas Aeruginosa Pneumonia (2012) (0)
S3-2 Characterization of Apaf-1-Like Molecules (2002) (0)
S-18 : Linking pathogen virulence, the microbiota and immunity (2014) (0)

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