Sonia Gandhi
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British physician and neuroscientist
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Why Is Sonia Gandhi Influential?
(Suggest an Edit or Addition)According to Wikipedia, Sonia Gandhi is a British physician and neuroscientist who leads the Francis Crick Institute neurodegeneration laboratory. She holds a joint position at the UCL Queen Square Institute of Neurology. Her research investigates the molecular mechanisms that give rise to Parkinson's disease. During the COVID-19 pandemic, Gandhi was involved with the epidemiological investigations and testing efforts at the Francis Crick Institute.
Sonia Gandhi 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mechanism of Oxidative Stress in Neurodegeneration (2012) (751)
- A common LRRK2 mutation in idiopathic Parkinson's disease (2005) (739)
- Preexisting and de novo humoral immunity to SARS-CoV-2 in humans (2020) (720)
- PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death (2009) (614)
- The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1 (2007) (493)
- Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination (2021) (414)
- PINK1 cleavage at position A103 by the mitochondrial protease PARL (2010) (408)
- Understanding the molecular causes of Parkinson's disease. (2006) (341)
- PINK1 protein in normal human brain and Parkinson's disease. (2006) (333)
- Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data. (2005) (324)
- PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons (2008) (311)
- α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease (2018) (283)
- Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease (2016) (254)
- UCHL1 is a Parkinson's disease susceptibility gene. (2004) (247)
- Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers (2020) (202)
- Molecular pathogenesis of Parkinson's disease. (2005) (185)
- A heterozygous effect for PINK1 mutations in Parkinson's disease? (2006) (175)
- Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading (2016) (173)
- Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress (2006) (165)
- Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons (2015) (133)
- Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS (2017) (124)
- Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease (2014) (120)
- Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase (2016) (118)
- Ca2+ is a key factor in α-synuclein-induced neurotoxicity (2016) (110)
- A novel prion disease associated with diarrhea and autonomic neuropathy. (2013) (105)
- PINK1 (PARK6) associated Parkinson disease in Ireland (2004) (103)
- Dopamine Induces Ca2+ Signaling in Astrocytes through Reactive Oxygen Species Generated by Monoamine Oxidase (2010) (103)
- Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation (2017) (101)
- Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (2020) (100)
- UCHL‐1 is not a Parkinson's disease susceptibility gene (2006) (97)
- Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: The CAPTURE study (2021) (97)
- Lipid peroxidation is essential for α‐synuclein‐induced cell death (2015) (96)
- AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC (2021) (95)
- Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids (2016) (95)
- Unravelling mitochondrial pathways to Parkinson's disease (2014) (93)
- Genome-wide association studies: the key to unlocking neurodegeneration? (2010) (92)
- Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis (2018) (89)
- Dopamine protects neurons against glutamate-induced excitotoxicity (2013) (88)
- Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases (2018) (78)
- Targeting mitochondrial dysfunction in neurodegenerative disease: Part II (2010) (75)
- Dopamine Induced Neurodegeneration in a PINK1 Model of Parkinson's Disease (2012) (72)
- Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease (2011) (68)
- Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates (2017) (66)
- A Multicenter Study of BRD2 as a Risk Factor for Juvenile Myoclonic Epilepsy (2007) (55)
- Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species (2017) (55)
- Molecular pathogenesis of Parkinson's disease. (2005) (54)
- Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2 (2021) (52)
- LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation (2019) (50)
- Targeting mitochondrial dysfunction in neurodegenerative disease: Part I (2010) (48)
- The mitochondrial protease HtrA 2 is regulated by Parkinson ’ s disease associated kinase PINK 1 (2007) (47)
- Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein (2016) (46)
- Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer (2022) (46)
- SARS-CoV-2 virus and antibodies in front-line Health Care Workers in an acute hospital in London: preliminary results from a longitudinal study (2020) (45)
- Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death (2020) (43)
- A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA (2018) (42)
- Neuropathology of primary adult-onset dystonia (2008) (40)
- Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains (2021) (36)
- Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells (2018) (35)
- Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons (2008) (35)
- Mitochondria in Parkinson disease: back in fashion with a little help from genetics. (2006) (33)
- Vildagliptin selectively ameliorates GLP-1, GLUT4, SREBP-1c mRNA levels and stimulates β-cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin-induced diabetes. (2012) (33)
- Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer (2021) (32)
- PINK 1 protein in normal human brain and Parkinson ’ s disease (2006) (32)
- A novel long acting DPP-IV inhibitor PKF-275-055 stimulates β-cell proliferation resulting in improved glucose homeostasis in diabetic rats. (2012) (32)
- Radiation-induced inflammatory cascade and its reverberating crosstalks as potential cause of post-radiotherapy second malignancies (2017) (31)
- Optical Structural Analysis of Individual α‐Synuclein Oligomers (2018) (30)
- Tau acts as an independent genetic risk factor in pathologically proven PD (2012) (27)
- Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study. (2021) (26)
- Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons (2017) (26)
- Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients (2022) (25)
- Potential nephrotoxic effects produced by steroidal saponins from hydro alcoholic extract of Tribulus terrestris in STZ-induced diabetic rats (2013) (25)
- Novel pathway for an old neurotransmitter: dopamine-induced neuronal calcium signalling via receptor-independent mechanisms. (2010) (25)
- Chronic DPP-IV inhibition with PKF-275-055 attenuates inflammation and improves gene expressions responsible for insulin secretion in streptozotocin induced diabetic rats. (2012) (24)
- SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies (2022) (24)
- What Have PINK1 and HtrA2 Genes Told Us about the Role of Mitochondria in Parkinson's Disease? (2008) (24)
- Inhibiting the Ca2+ Influx Induced by Human CSF (2017) (22)
- Dissecting the Phenotype and Genotype of PLA2G6‐Related Parkinsonism (2021) (21)
- Oculoleptomeningeal Amyloidosis associated with transthyretin Leu12Pro in an African patient (2014) (21)
- Aliskiren improves insulin resistance and ameliorates diabetic renal vascular complications in STZ-induced diabetic rats (2013) (20)
- Functional antibody and T-cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study (2021) (19)
- Correction to: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis (2018) (19)
- Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons (2008) (18)
- Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity (2022) (17)
- NR4A2 genetic variation in sporadic Parkinson's disease: A genewide approach (2006) (17)
- SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay. (2021) (16)
- Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study. (2021) (15)
- Proteomic analyses of zebra finch optic tectum and comparative histochemistry. (2007) (14)
- SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay (2020) (14)
- "Omics" of High Altitude Biology: A Urinary Metabolomics Biomarker Study of Rats Under Hypobaric Hypoxia. (2015) (13)
- Mutations and mechanism: how PINK1 may contribute to risk of sporadic Parkinson's disease. (2017) (12)
- Metabolic regulatory variations in rats due to acute cold stress & Tinospora Cordifolia intervention: high resolution 1H NMR approach (2012) (12)
- Scalable and Resilient SARS-CoV2 testing in an Academic Centre (2020) (11)
- An experimental assessment of toxic potential of nanoparticle preparation of heavy metals in streptozotocin induced diabetes. (2013) (11)
- The Impact of Type 2 Diabetes in Parkinson's Disease (2021) (11)
- Ca2+ is a key factor in α-synuclein-induced neurotoxicity (2016) (11)
- Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy (2020) (11)
- Neurometabolic and structural alterations in rat brain due to acute hypobaric hypoxia: in vivo 1H MRS at 7 T (2014) (11)
- A common mutation in idiopathic Parkinson's disease (2005) (10)
- French Parkinson's Disease Genetics Study Group are Y. Agid, (2005) (9)
- Waldenstrom's Macroglobulinemia Presenting as Goodpasture's Syndrome (2004) (9)
- Adult-onset Leigh syndrome linked to the novel stop codon mutation m.6579G>A in MT-CO1. (2019) (8)
- Microstructure elucidation of poly(9-ethyl-3-hydroxymethylcarbazolyl methacrylate) using two-dimensional NMR spectroscopy (2005) (8)
- Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at Chr16q11.2 and on the MAPT H1 allele (2020) (8)
- Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s (2022) (7)
- Relationships between the islets blood flow, nitric oxide, insulin, and cytosolic calcium in rat pancreatic islets: effects of DPP-IV inhibitor vildagliptin. (2012) (7)
- Calcium is a key factor in α-synuclein induced neurotoxicity (2016) (7)
- Clinical outcomes of SARS-CoV-2 pandemic in long-term care facilities for people with epilepsy: observational study (2020) (6)
- Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons (2022) (6)
- Opicapone Efficacy and Tolerability in Parkinson's Disease Patients Reporting Insufficient Benefit/Failure of Entacapone (2020) (5)
- Morphology and Motional Heterogeneity in PS/PMMA Diblock Copolymers Studied by 1H and 13C Solid‐State NMR Spectroscopy (2008) (5)
- Effective blockade of RAAS by combination of aliskiren and olmesartan improves glucose homeostasis, glomerular filtration rate along with renal variables in streptozotocin induced diabetic rats. (2012) (5)
- The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of their Potential Efficacy and Suitability (2021) (4)
- Population genetic approaches to neurological disease: Parkinson's disease as an example (2005) (4)
- Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci (2022) (4)
- Emergence of new subgenomic mRNAs in SARS-CoV-2 (2022) (4)
- Cell autonomous and non-cell autonomous mechanisms of disease in VCP-related ALS (2017) (3)
- Pseudogenes limit the identification of novel common transcripts generated by their parent genes (2022) (3)
- Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (2020) (3)
- Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (2020) (2)
- Overproduction of reactive oxygen species is the primary pathological event related to neuronal cell death in iPSC derived neurons from patients with familial Parkinson's disease (2018) (2)
- Microstructure determination of 9-ethyl-3-hydroxymethylcarbazolyl acrylate/methacrylonitrile using two-dimensional NMR spectroscopy (2007) (2)
- PATU2 Novel truncation mutation of PRNP causes chronic diarrhoea, sensory neuropathy and autonomic failure associated with prion protein deposition in the cerebral blood vessels and small bowel (2010) (2)
- Single-Molecule Characterisation of Alpha-Synuclein Oligomers (2014) (2)
- Structural investigations of (9-ethyl-carbazol-6-yl) methyl methacrylate/methyl acrylate copolymers using two-dimensional NMR spectroscopy (2006) (2)
- Diabetes and Neuroaxonal Damage in Parkinson's Disease (2022) (2)
- A Physiological Role for Alpha-Synuclein in the Regulation of ATP Synthesis (2016) (1)
- Uncovering early markers of Parkinson's disease pathological progression using proteomics (2013) (1)
- Inhibiting the Ca 2 + Influx In duced by Human CSF Graphical (2017) (1)
- Cytokine release syndrome in a patient with colorectal cancer following vaccination with BNT162b2 (tozinameran) (2021) (1)
- Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species (2017) (1)
- Misuse of SARS-CoV-2 testing in symptomatic health-care staff in the UK – Authors' reply (2020) (1)
- Neurogenetics: The human genome project – what it really means and where next (2012) (1)
- Current Metabolomic Methodologies & their Application to Thermal Stress (2014) (1)
- Studies on metabolic alterations due to hypobaric hypoxia in serum using NMR spectroscopy (2022) (1)
- Synthesis and Characterization of Drug Loaded Chitosan Biocomposite Films for Dermal Application (2014) (1)
- Alpha-synuclein induces ferroptosis through generation of lipid peroxidation and calcium deregulation (2018) (1)
- Broad human and animal coronavirus neutralisation by SARS-CoV-2 S2-targeted vaccination (2021) (1)
- PINK1: a novel mitochondrial protein in Parkinson's disease (2006) (1)
- Case report: Paradoxical responses to short acting beta-agonists in a pediatric patient (2021) (1)
- Correction to ‘Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species’ (2018) (1)
- ELECTROLYTE IMBALANCE TRIGGERING RELAPSE OF INFLAMMATORY NEUROPATHY (2013) (1)
- Micro structure elucidation of poly ( 9-ethyl-3-hydroxymethylcarbazolyl methacrylate ) using two-dimensional NMR spectroscopy (2006) (0)
- A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA (2018) (0)
- Strain Dependent Effects of Alpha-Synuclein Mutations on Mitochondrial Dysfunction (2016) (0)
- Author Correction: Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity (2022) (0)
- Altered ER Homeostasis and Mitochondria ER Network in PINK1 Deficient Parkinson's Disease Models (2016) (0)
- Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s (2022) (0)
- WITHDRAWN: Correlative 1H MRS and High Resolution NMR Metabolomics to study Neurometabolic alterations in Rat Brain due to Chronic Hypobaric Hypoxia. (2018) (0)
- SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay [version 2; peer review: 2 approved with reservations] (2021) (0)
- Differential effects of mutant alpha-synuclein monomers, oligomers and fibrils on mitochondria function and ROS production (2015) (0)
- Alpha-Synuclein Induces Mitochondrial Dysfunction Leading to a Higher Susceptibility of PTP Opening (2014) (0)
- Dementia and neurodegeneration : Challenges and opportunities Fundamental research : From molecules to neural circuitry (2013) (0)
- Amyloid precipitation in biofluids using a structure-specific chemical antibody (2020) (0)
- Investigation of PINK1 dysfunction in Parkinson's disease (2006) (0)
- Tracking Oligomerization of Alpha-Synuclein Demonstrates Pivotal Role of Mitochondria in Seeding (2020) (0)
- Site-Specific Hydration Dynamics Illuminates the Key Structural Features of Membrane-Bound -Synuclein (2014) (0)
- A kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading Short title : Templated seeding of alpha-synuclein aggregation (2016) (0)
- Novel Truncation Mutation of PRNP Causes Chronic Diarrhoea, Sensory Neuropathy and Autonomic Failure Associated with Prion Protein Deposition in the Cerebral Blood Vessels and Small Bowel (2010) (0)
- Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD (2017) (0)
- Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (2020) (0)
- AgProtect - an information technology based information dissemination system for crop protection. (2006) (0)
- T 2 MR Relaxometry Study of Acute Heat Stress induced changes in Rat Brain at 7 T (2011) (0)
- Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons (2022) (0)
- SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay [version 1; peer review: 2 approved with reservations] (2021) (0)
- Alpha-synuclein expression in early stage post-mortem Parkinson's disease brain (2014) (0)
- ANTI-EPILEPTIC DRUGS IN CHILDREN (2019) (0)
- A Makeup Artist with Crohn’s Disease (2017) (0)
- Neuropathology of primary dystonia unrelated to DYT1 mutations (2007) (0)
- Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells (2018) (0)
- Microstructure characterization of poly(2-N-carbazolylethyl acrylate) by two-dimensional NMR spectroscopy (2005) (0)
- LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation (2019) (0)
- A Novel Prion Disease Presenting with Diarrhea and Autonomic Neuropathy (2013) (0)
- First stage association analysis of neuropatholically proven PD confirms MAPT as an independent risk factor for PD (2012) (0)
- The annotation and function of the Parkinson’s and Gaucher disease-linked gene GBA1 has been concealed by its protein-coding pseudogene GBAP1 (2023) (0)
- Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death (2020) (0)
- Mitochondrial dysfunction in Parkinson's disease: Is it the earliest feature? (2015) (0)
- PINK1 Deficiency and Mitochondrial Dysfunction in Neurons and Skeletal Myocytes (2010) (0)
- α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease (2018) (0)
- PINK1 protein distribution in normal human brain and Parkinson's disease (2005) (0)
- SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay [ version 2 ; peer review : 2 approved ] (2021) (0)
- PINK1 is necessary for long term survival and mitochondrial function in primary human dopaminergic neurons (2009) (0)
- SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay [version 1; peer review: 1 approved with reservations] (2021) (0)
- The Role of alpha-Synuclein Oligomerisation in Parkinson’s Disease (P1.043) (2014) (0)
- Silent Networking Using Fuzzy Logic For Power Saving In Networked Devices (2013) (0)
- Cover Feature: Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells (ChemBioChem 19/2018) (2018) (0)
- Deep learning in human neurons predicts mechanistic subtypes of Parkinson’s (2022) (0)
- Anti-national forces spreading venom : (2020) (0)
- Investigation of new pharmacological interventions for diabetic nephropathy in experimentally induced niddm in rats (2012) (0)
- Physiology and pathology of alpha-synuclein (2017) (0)
- A site-directed mutagenesis study of putative cleavage sites of the Parkinson's disease associated gene, PINK1 (2006) (0)
- Alpha-Synuclein Modulates [Ca2+]c of Neurons and Astrocytes that Trigger Cell Death (2014) (0)
- Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson’s disease (2020) (0)
- WEIGHT LOSS, ENCEPHALOPATHY, URINARY DIFFICULTIES AND NUMB FEET IN A NIGERIAN MAN (2013) (0)
- Neuropathology of primary adult onset non-DYT1 dystonia (2008) (0)
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Sonia Gandhi is affiliated with the following schools:
