Gavin Y. Oudit

Q: What Schools Are Affiliated With Gavin Y. Oudit

Gavin Y. Oudit is affiliated with the following schools: Ohio State University, University of Alberta, University of Toronto

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Gavin Y. Oudit

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Why Is Gavin Y. Oudit Influential?

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According to Wikipedia, Gavin Yadram Oudit is a Canadian cardiologist and clinician-scientist. As a Tier 2 Canada Research Chair in Heart Failure at the University of Alberta, Oudit also serves as Director of the Heart Function Clinic and Mazankowski Alberta Heart Institute.

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Gavin Y. Oudit's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes (2020) (1723)
Angiotensin-converting enzyme 2 is an essential regulator of heart function (2002) (1660)
Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System (2020) (821)
SARS‐coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS (2009) (760)
Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways (2002) (608)
Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure. (2016) (600)
Cells of the adult human heart (2020) (540)
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. (2004) (500)
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy (2003) (434)
Dendritic cell–induced autoimmune heart failure requires cooperation between adaptive and innate immunity (2003) (387)
Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction (2010) (383)
Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy (2009) (283)
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. (2008) (281)
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters. (2008) (276)
Regulation of cardiac excitation–contraction coupling by action potential repolarization: role of the transient outward potassium current (Ito) (2003) (264)
Multidisciplinary Approach to Novel Therapies in Cardio-Oncology Research (MANTICORE 101-Breast): A Randomized Trial for the Prevention of Trastuzumab-Associated Cardiotoxicity. (2017) (260)
Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS. (2014) (257)
Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. (2007) (248)
The role of ACE2 in cardiovascular physiology. (2003) (246)
Empagliflozin Increases Cardiac Energy Production in Diabetes (2018) (244)
Cardiac regulation by phosphoinositide 3-kinases and PTEN. (2008) (238)
Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. (2007) (233)
Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. (2008) (232)
Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II-Dependent Glomerulosclerosis (2006) (230)
Iron-overload cardiomyopathy: pathophysiology, diagnosis, and treatment. (2010) (225)
Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia (2012) (219)
The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium. (2001) (207)
Prevention of Angiotensin II–Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2 (2011) (206)
Taurine Supplementation Reduces Oxidative Stress and Improves Cardiovascular Function in an Iron-Overload Murine Model (2004) (204)
Loss of Angiotensin-Converting Enzyme 2 Accelerates Maladaptive Left Ventricular Remodeling in Response to Myocardial Infarction (2009) (202)
Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy (2006) (201)
Angiotensin Converting Enzyme 2: A Double-Edged Sword. (2020) (197)
Muscle-Specific Loss of Apoptosis-Inducing Factor Leads to Mitochondrial Dysfunction, Skeletal Muscle Atrophy, and Dilated Cardiomyopathy (2005) (194)
Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice (2018) (187)
ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity (2015) (186)
The renin-angiotensin system: going beyond the classical paradigms (2019) (173)
Combination of Tumor Necrosis Factor-α Ablation and Matrix Metalloproteinase Inhibition Prevents Heart Failure After Pressure Overload in Tissue Inhibitor of Metalloproteinase-3 Knock-Out Mice (2005) (168)
T1 Mapping With Cardiovascular MRI Is Highly Sensitive for Fabry Disease Independent of Hypertrophy and Sex (2013) (165)
Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues (2013) (165)
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. (2009) (150)
Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease (2017) (150)
Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure. (2017) (148)
Angiotensin 1–7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation (2014) (147)
Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload. (1999) (143)
Phosphoinositide 3-Kinase &ggr;–Deficient Mice Are Protected From Isoproterenol-Induced Heart Failure (2003) (142)
Metabolomic Fingerprint of Heart Failure with Preserved Ejection Fraction (2015) (136)
Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System (2016) (135)
TIMP2 Deficiency Accelerates Adverse Post–Myocardial Infarction Remodeling Because of Enhanced MT1-MMP Activity Despite Lack of MMP2 Activation (2010) (132)
Loss of Angiotensin-Converting Enzyme-2 Exacerbates Diabetic Cardiovascular Complications and Leads to Systolic and Vascular Dysfunction: A Critical Role of the Angiotensin II/AT1 Receptor Axis (2012) (132)
ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4. (2013) (131)
Loss of TIMP3 enhances interstitial nephritis and fibrosis. (2009) (126)
Agonist-Induced Hypertrophy and Diastolic Dysfunction Are Associated With Selective Reduction in Glucose Oxidation: A Metabolic Contribution to Heart Failure With Normal Ejection Fraction (2012) (119)
Hydroxychloroquine-induced cardiomyopathy: case report, pathophysiology, diagnosis, and treatment. (2014) (118)
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice. (2004) (116)
Erythropoietin Protects against Doxorubicin-Induced Cardiomyopathy via a Phosphatidylinositol 3-Kinase-Dependent Pathway (2008) (113)
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. (2008) (111)
Angiotensin‐converting‐enzyme 2 inhibits liver fibrosis in mice (2009) (109)
Comparative Proteomics Profiling of a Phospholamban Mutant Mouse Model of Dilated Cardiomyopathy Reveals Progressive Intracellular Stress Responses*S (2008) (106)
Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity. (2014) (106)
Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression (2011) (104)
Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload. (2013) (102)
Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. (2006) (99)
Circulating Levels of Tumor Necrosis Factor-Alpha Receptor 2 Are Increased in Heart Failure with Preserved Ejection Fraction Relative to Heart Failure with Reduced Ejection Fraction: Evidence for a Divergence in Pathophysiology (2014) (99)
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones (2020) (98)
Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction. (2014) (97)
Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. (2010) (96)
Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction (2011) (95)
Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63–Integrin &bgr;1 Interaction (2017) (94)
Simultaneous Transforming Growth Factor β-Tumor Necrosis Factor Activation and Cross-talk Cause Aberrant Remodeling Response and Myocardial Fibrosis in Timp3-deficient Heart* (2009) (92)
Cardioprotective Effects Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin 1-7 in Experimental Heart Failure in Angiotensin-Converting Enzyme 2–Null Mice (2012) (92)
Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury (2012) (91)
Lack of Tissue Inhibitor of Metalloproteinases 2 Leads to Exacerbated Left Ventricular Dysfunction and Adverse Extracellular Matrix Remodeling in Response to Biomechanical Stress (2011) (89)
Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. (2011) (88)
Mice with Tissue Inhibitor of Metalloproteinases 4 (Timp4) Deletion Succumb to Induced Myocardial Infarction but Not to Cardiac Pressure Overload* (2010) (86)
Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation (2006) (86)
ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity (2016) (83)
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases. (2017) (80)
Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction. (2010) (80)
Apelin Is a Negative Regulator of Angiotensin II–Mediated Adverse Myocardial Remodeling and Dysfunction (2017) (80)
Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy (2015) (79)
ACE2 Deficiency Enhances Angiotensin II-Mediated Aortic Profilin-1 Expression, Inflammation and Peroxynitrite Production (2012) (79)
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. (2003) (75)
Resveratrol Treatment of Mice With Pressure-Overload–Induced Heart Failure Improves Diastolic Function and Cardiac Energy Metabolism (2015) (75)
Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease. (2017) (75)
Angiotensin-Converting Enzyme 2 Is a Critical Determinant of Angiotensin II–Induced Loss of Vascular Smooth Muscle Cells and Adverse Vascular Remodeling (2014) (75)
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure (2019) (74)
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease (2018) (73)
Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications. (2014) (72)
Inhibition of Calcineurin and Sarcolemmal Ca2+ Influx Protects Cardiac Morphology and Ventricular Function in Kv4.2N Transgenic Mice (2002) (71)
Role of iron metabolism in heart failure: From iron deficiency to iron overload. (2019) (70)
Systolic and diastolic function assessment in fabry disease patients using speckle-tracking imaging and comparison with conventional echocardiographic measurements. (2013) (70)
Phosphatidylinositol 3-Kinase &ggr; Is a Critical Mediator of Myocardial Ischemic and Adenosine-Mediated Preconditioning (2008) (65)
Insulin-Like Growth Factor-1 and PTEN Deletion Enhance Cardiac L-Type Ca2+ Currents via Increased PI3Kα/PKB Signaling (2006) (65)
Loss of Timp3 Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II* (2012) (63)
Recombinant Human Angiotensin-Converting Enzyme 2 as a New Renin-Angiotensin System Peptidase for Heart Failure Therapy (2011) (62)
Clinical and pathophysiological effects of active and passive smoking on the cardiovascular system. (1998) (59)
Angiotensin‐converting enzyme 2 antagonizes angiotensin II‐induced pressor response and NADPH oxidase activation in Wistar–Kyoto rats and spontaneously hypertensive rats (2013) (59)
Role of ACE2 in diastolic and systolic heart failure (2012) (58)
Angiotensin-(1-7)-induced activation of ERK1/2 is cAMP/protein kinase A-dependent in glomerular mesangial cells. (2012) (58)
Anderson-Fabry cardiomyopathy: prevalence, pathophysiology, diagnosis and treatment (2015) (58)
Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase. (2004) (57)
Loss of ACE2 Exacerbates Murine Renal Ischemia-Reperfusion Injury (2013) (57)
Cyclophosphamide-Induced Cardiomyopathy (2013) (57)
Plasma angiotensin-converting enzyme 2: novel biomarker in heart failure with implications for COVID-19 (2020) (57)
SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes (2020) (55)
Loss of PI3K&ggr; Enhances cAMP-Dependent MMP Remodeling of the Myocardial N-Cadherin Adhesion Complexes and Extracellular Matrix in Response to Early Biomechanical Stress (2010) (53)
Distinct functions of junD in cardiac hypertrophy and heart failure. (2005) (52)
Loss of p47phox Subunit Enhances Susceptibility to Biomechanical Stress and Heart Failure Because of Dysregulation of Cortactin and Actin Filaments (2013) (51)
The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides (2016) (51)
Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency. (2019) (50)
Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways (2013) (50)
Impact of the renin-angiotensin system on cardiac energy metabolism in heart failure. (2013) (48)
MELAS syndrome and cardiomyopathy: linking mitochondrial function to heart failure pathogenesis (2015) (48)
Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction (2019) (47)
Chloroquine‐induced cardiomyopathy: a reversible cause of heart failure (2018) (46)
ACE2/Ang-(1–7) signaling and vascular remodeling (2014) (46)
TIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury. (2014) (46)
A novel mutation in the RYR2 gene leading to catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation: dose-dependent arrhythmia-event suppression by β-blocker therapy. (2011) (45)
Dorsal aortic and organ blood flow decrease following Stanniectomy in freshwater North American eels (Anguilla rostrata LeSueur) (1994) (45)
Myocardial Recovery From Ischemia–Reperfusion Is Compromised in the Absence of Tissue Inhibitor of Metalloproteinase 4 (2014) (43)
The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents. (2004) (43)
Adeno-Associated Virus Overexpression of Angiotensin-Converting Enzyme-2 Reverses Diabetic Retinopathy in Type 1 Diabetes in Mice. (2016) (43)
Elevated Inflammatory Plasma Biomarkers in Patients With Fabry Disease: A Critical Link to Heart Failure With Preserved Ejection Fraction (2018) (42)
ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue. (2019) (42)
Loss of Angiotensin‐Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction (2018) (42)
Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse (2012) (41)
Angiotensin II and cardiovascular regulation in a freshwater teleost, Anguilla rostrata LeSueur. (1995) (41)
ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases: Ramifications for the Control of SARS-CoV-2. (2020) (41)
Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. (2006) (41)
Loss of TIMP3 selectively exacerbates diabetic nephropathy. (2012) (40)
Antagonism of angiotensin 1–7 prevents the therapeutic effects of recombinant human ACE2 (2015) (40)
ACE inhibitor-induced angioedema of the intestine: Case report, incidence, pathophysiology, diagnosis and management. (2001) (40)
Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway. (2013) (40)
Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm (2018) (38)
Cardiac Sarcoplasmic Reticulum Calcium Release and Load Are Enhanced by Subcellular cAMP Elevations in PI3K&ggr;-Deficient Mice (2005) (38)
Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post–Myocardial Infarction Repair by Regulating Angiogenesis (2015) (38)
Loss of NOX2 (gp91phox) prevents oxidative stress and progression to advanced heart failure. (2014) (38)
Murine recombinant angiotensin-converting enzyme 2 attenuates kidney injury in experimental Alport syndrome. (2017) (38)
A Disintegrin and Metalloprotease-17 Regulates Pressure Overload–Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin &bgr;1 (2016) (37)
Role of PI3Kα and sarcolemmal ATP-sensitive potassium channels in epoxyeicosatrienoic acid mediated cardioprotection. (2012) (37)
Lithium-induced sinus node disease at therapeutic concentrations: linking lithium-induced blockade of sodium channels to impaired pacemaker activity. (2007) (36)
Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron‐overload (2016) (36)
The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders (2019) (36)
Recombinant Human ACE2 and the Angiotensin 1-7 Axis as Potential New Therapies for Heart Failure. (2017) (35)
Gender‐specific plasma proteomic biomarkers in patients with Anderson–Fabry disease (2015) (35)
Reduced Right Ventricular Native Myocardial T1 in Anderson-Fabry Disease: Comparison to Pulmonary Hypertension and Healthy Controls (2016) (35)
Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs (2019) (35)
Physiological roles of angiotensin-converting enzyme 2. (2004) (35)
Clinical Features, Diagnosis, and Management of Patients With Anderson-Fabry Cardiomyopathy. (2017) (35)
Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure. (2016) (34)
S4153R is a gain-of-function mutation in the cardiac Ca(2+) release channel ryanodine receptor associated with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation. (2013) (34)
Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation. (2017) (33)
Cardiorenal Syndrome and Heart Failure-Challenges and Opportunities. (2019) (33)
Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling (2015) (33)
Atrial fibrillation and heart failure in the elderly (2012) (33)
Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease. (2020) (33)
Role of phosphatidylinositol 3-kinase gamma in the beta-cell: Interactions with glucagon-like peptide-1 (2006) (32)
Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease (2014) (32)
Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury. (2019) (31)
Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTOR/ERK signaling in apolipoprotein E-deficient mice (2016) (31)
Angiotensin 1-7 stimulates brown adipose tissue and reduces diet-induced obesity. (2018) (31)
Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice (2013) (31)
Role of Phosphoinositide 3-Kinase &agr;, Protein Kinase C, and L-Type Ca2+ Channels in Mediating the Complex Actions of Angiotensin II on Mouse Cardiac Contractility (2010) (30)
Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents. (2019) (29)
Ces3/TGH Deficiency Attenuates Steatohepatitis (2016) (29)
Homocysteine, vitamins, and coronary artery disease. Comprehensive review of the literature. (2000) (29)
Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling (2016) (29)
The role of ACE2 in pulmonary diseases—relevance for the nephrologist (2009) (28)
Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases. (2014) (28)
Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress (2017) (27)
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies (2022) (27)
Characterization of the intrarenal renin-angiotensin system in experimental alport syndrome. (2015) (27)
The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study (2014) (26)
Targeting the ACE2 and Apelin Pathways Are Novel Therapies for Heart Failure: Opportunities and Challenges (2012) (26)
Cardiovascular effects of arginine vasotocin, atrial natriuretic peptide, and epinephrine in freshwater eels. (1995) (26)
Determinants of ventricular arrhythmias in human explanted hearts with dilated cardiomyopathy (2015) (25)
Differentiating heart failure phenotypes using sex‐specific transcriptomic and proteomic biomarker panels (2017) (25)
Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries (2021) (25)
Novel mutation in exon 14 of the sarcomere gene MYH7 in familial left ventricular noncompaction with bicuspid aortic valve. (2014) (25)
Weight loss enhances cardiac energy metabolism and function in heart failure associated with obesity (2019) (24)
Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming. (2017) (24)
The Use of ω-3 Poly-Unsaturated Fatty Acids in Heart Failure: A Preferential Role in Patients with Diabetes (2012) (24)
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes (2020) (24)
Effects of hypoxia-induced intrauterine growth restriction on cardiac siderosis and oxidative stress (2012) (22)
Angiotensin-I- and -III-mediated cardiovascular responses in the freshwater North American eel, Anguilla rostrata: effect of Phe8 deletion. (1995) (22)
Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts (2018) (22)
Unravelling the molecular basis for cardiac iron metabolism and deficiency in heart failure. (2016) (22)
SARS-CoV-2 perturbs the renin-angiotensin system and energy metabolism (2020) (22)
Role of PI3 kinase gamma in excitation-contraction coupling and heart disease. (2007) (22)
Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure. (2017) (21)
What’s new in the renin-angiotensin system? (2004) (21)
ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)–Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm (2020) (21)
Corpuscles of Stannius and blood flow regulation in freshwater North American eels, Anguilla rostrata LeSueur. (1995) (20)
Angiotensin II-mediated catecholamine release during the pressor response in rats. (1994) (20)
Elevated Angiotensin 1–7/Angiotensin II Ratio Predicts Favorable Outcomes in Patients With Heart Failure (2020) (19)
Cells and gene expression programs in the adult human heart (2020) (19)
PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart. (2015) (19)
Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease. (2018) (19)
Left ventricular aneurysm in a patient with mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome): clinical and pathological correlation. (2007) (19)
Electrophysiological profiling of cardiomyocytes in embryonic bodies derived from human embryonic stem cells: therapeutic implications. (2003) (18)
Response by the corpuscles of Stannius to hypotensive stimuli in three divergent ray-finned fishes (Amia calva, Anguilla rostrata, and Catastomus commersoni): cardiovascular and morphological changes. (2003) (18)
TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease. (2018) (18)
Comparison of Cardiac Magnetic Resonance Imaging and Echocardiography in Assessment of Left Ventricular Hypertrophy in Fabry Disease. (2018) (18)
Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1. (2006) (17)
A case of lamin A/C mutation cardiomyopathy with overlap features of ARVC: a critical role of genetic testing. (2013) (17)
Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling. (2013) (17)
Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications. (2020) (17)
Response to Comment on Patel et al. ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes 2016;65:85–95 (2016) (16)
Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy. (2014) (16)
Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury. (2018) (15)
Homocysteine, vitamins, and coronary artery disease (2000) (15)
Plasma Microbiome in COVID-19 Subjects: An Indicator of Gut Barrier Defects and Dysbiosis (2022) (15)
Abstract PD5-03: Prophylactic beta blockade preserves left ventricular ejection fraction in HER2-overexpresssing breast cancer patients receiving trastuzumab: Primary results of the MANTICORE randomized controlled trial (2016) (15)
Tetrapod-type [Asp1] angiotensin is present in a holostean fish, Amia calva. (1998) (15)
Trafficking Defect and Proteasomal Degradation Contribute to the Phenotype of a Novel KCNH2 Long QT Syndrome Mutation (2011) (15)
Proteomic biomarkers of recovered heart function (2014) (14)
Change of Health‐Related Quality of Life Over Time and Its Association With Patient Outcomes in Patients With Heart Failure (2020) (14)
Angiotensin-Converting Enzyme-2 (ACE2)—A New Player in the Genesis of Glomerular Injury? Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II–Dependent Glomerulosclerosis. Am J Pathol 168: 1808–1820, 2006 (2006) (13)
Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm (2014) (13)
Chapter 3 – Voltage-regulated Potassium Channels (2004) (13)
Layer-specific strain in patients with heart failure using cardiovascular magnetic resonance: not all layers are the same (2020) (13)
Angiotensin I- and II- and norepinephrine-mediated pressor responses in an ancient holostean fish, the bowfin (Amia calva). (1995) (13)
Cardiac and Cardiometabolic Phenotyping of Trastuzumab-Mediated Cardiotoxicity: a Secondary Analysis of the MANTICORE trial. (2021) (13)
Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts. (2019) (13)
Ventricular tachycardia in patients with type 1 myotonic dystrophy: a case series (2019) (13)
Quantification of circumferential, longitudinal, and radial global fractional shortening using steady‐state free precession cines: A comparison with tissue‐tracking strain and application in fabry disease (2015) (13)
Titration and Tolerability of Sacubitril/Valsartan for Patients With Heart Failure in Clinical Practice (2019) (13)
Response by Gheblawi et al to Letter Regarding Article, "Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2". (2020) (12)
Role of phosphatidylinositol-3 kinase-γ in the actions of glucagon-like peptide-2 on the murine small intestine (2007) (12)
Effect of Active Cancer on the Cardiac Phenotype: A Cardiac Magnetic Resonance Imaging‐Based Study of Myocardial Tissue Health and Deformation in Patients With Chemotherapy‐Naïve Cancer (2021) (12)
Cardiomyopathies and Genetic Testing in Heart Failure: Role in Defining Phenotype-Targeted Approaches and Management. (2021) (12)
Quantification of lung water in heart failure using cardiovascular magnetic resonance imaging (2019) (12)
The Human Explanted Heart Program: A translational bridge for cardiovascular medicine (2020) (12)
Cardiac Intervention Improves Heart Disease and Clinical Outcomes in Patients With Muscular Dystrophy in a Multidisciplinary Care Setting (2020) (11)
Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity. (2020) (11)
Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists (2021) (11)
Effects of age, gender, and risk‐factors for heart failure on native myocardial T1 and extracellular volume fraction using the SASHA sequence at 1.5T (2018) (10)
Comparison of Usefulness of Cardiac Resynchronization Therapy in Patients With Type 1 Myotonic Dystrophy With Versus Without Left Bundle Branch Block. (2019) (10)
Screening for Fabry Disease in patients with unexplained left ventricular hypertrophy (2020) (10)
COVID-19 Pandemic: Global Impact and Potential Implications for Cardiovascular Disease in Canada (2020) (10)
Novel Dominant-Negative Mutation in Cardiac Troponin I Causes Severe Restrictive Cardiomyopathy. (2017) (10)
Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy (2017) (10)
PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction (2019) (10)
Myocardial Iron Deficiency and Mitochondrial Dysfunction in Advanced Heart Failure in Humans (2022) (10)
Inactivation of endothelial cell phosphoinositide 3-kinase β inhibits tumor angiogenesis and tumor growth (2020) (10)
Glycogen Storage Disease Because of a PRKAG2 Mutation Causing Severe Biventricular Hypertrophy and High-Grade Atrio-Ventricular Block. (2016) (10)
Erratum: Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity (Nature Medicine (2003) 9 (1484-1490)) (2004) (9)
PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias (2019) (9)
Voltage‐gated Ca2+ channels as key mediators of iron‐transport and iron‐overload cardiomyopathy: L‐type vs. T‐type Ca+ channels (2012) (9)
Normal left-atrial structure and function despite concentric left-ventricular remodelling in a cohort of patients with Anderson-Fabry disease. (2015) (9)
Use of oral proton pump inhibitors is not associated with harm in patients with chronic heart failure in an ambulatory setting (2011) (9)
A prospective evaluation of the established criteria for heart failure with preserved ejection fraction using the Alberta HEART cohort (2017) (9)
Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury (2021) (9)
Left atrial remodelling, mid-regional pro-atrial natriuretic peptide, and prognosis across a range of ejection fractions in heart failure. (2020) (9)
A case of appropriate inappropriate device therapy: hyperkalemia-induced ventricular oversensing. (2008) (9)
Images in cardiovascular medicine. Left ventricular aneurysm associated with mucopolysaccharidosis type VI syndrome (Maroteaux-Lamy syndrome). (2007) (9)
Uncoupling between enhanced excitation-contraction coupling and the response to heart disease: lessons from the PI3Kγ knockout murine model. (2011) (8)
Hydrogen sulfide: an old gas with new cardioprotective effects. (2015) (8)
The tumor microenvironment may trigger lymphoproliferation in cardiac myxoma (2020) (8)
Effects of ANG II and III and angiotensin receptor blockers on nasal salt gland secretion and arterial blood pressure in conscious Pekin ducks (Anas platyrhynchos) (1998) (8)
The harbinger of mortality in heart failure with preserved ejection fraction: do GDF-15 levels reflect tandem, deterministic effects of fibrosis and inflammation? (2014) (7)
Effects of parenteral iron on inflammation and the myocardium in hemodialysis patients (2008) (7)
Corpuscles of Stannius and stanniocalcin-like immunoreactivity in the white sucker (Catostomus commersoni): evidence for a new cell-type (1998) (7)
S 4153 R Is a Gain-of-Function Mutation in the Cardiac Ca 2 þ Release Channel Ryanodine Receptor Associated With Catecholaminergic Polymorphic Ventricular Tachycardia and Paroxysmal Atrial Fibrillation (2013) (7)
Advanced Dilated Cardiomyopathy in a Patient With Hutterite Limb-Girdle Muscular Dystrophy: Use of a Left Ventricular Assist Device. (2018) (7)
Increased Mortality Associated With Adaptive Servo-Ventilation Therapy in Heart Failure Patients With Central Sleep Apnea in the Halted SERVE-HF Trial. (2015) (7)
Use of ginseng to reduce post-myocardial adverse myocardial remodeling: applying scientific principles to the use of herbal therapies (2011) (7)
Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium (2020) (7)
Stress‐Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics (2020) (7)
Manipulating angiotensin metabolism with angiotensin converting enzyme 2 (ACE2) in heart failure (2012) (6)
Dual loss of PI3Kα and PI3Kγ signaling leads to an age-dependent cardiomyopathy. (2014) (6)
Ectopic expression of Cdk 8 induces eccentric hypertrophy and heart failure (2017) (6)
Low altitude simulation without hypoxia improves left ventricular function after myocardial infarction by reducing ventricular afterload (2019) (6)
Angiotensin Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis and Diastolic Dysfunction (2010) (6)
Amlodipine Therapy for Iron-Overload Cardiomyopathy: The Enduring Value of Translational Research. (2016) (6)
Angiotensin-( 1 – 7 )-induced activation of ERK 1 / 2 is cAMP / protein kinase A-dependent in glomerular mesangial cells (2012) (6)
Image of the month. Angiotensin-converting enzyme (ACE) inhibitor angioedema of the intestine. (2000) (6)
Breast Cancer Patients Receiving Anthracycline Chemotherapy and Trastuzumab Have Biventricular Dysfunction and Reduced Heart Mass. (2018) (6)
The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of I k,slow currents (2004) (6)
Role of phosphatidylinositol-3 kinase-gamma in the actions of glucagon-like peptide-2 on the murine small intestine. (2007) (6)
Hemochromatosis Protein (HFE) Knockout Mice As a Novel Model of Hemochromatosis: Implications for Study and Management of Iron-Overload Cardiomyopathy. (2017) (6)
Cardiac Complications of Common Drugs of Abuse: Pharmacology, Toxicology and Management. (2021) (6)
Acute coronary thrombosis in a patient with diabetes and severe hyperglycemia. (2009) (6)
Mapping with CMR Is Highly Sensitive for Fabry Disease Independent of Hypertrophy and Gender (2013) (6)
Cardiovascular toxicity of PI3Kα inhibitors. (2020) (6)
Evaluating the Diagnostic and Prognostic Value of Biomarkers for Heart Disease and Major Adverse Cardiac Events in Patients With Muscular Dystrophy. (2020) (6)
Structural Valve Deterioration Is Linked to Increased Immune Infiltrate and Chemokine Expression (2020) (5)
Barth Syndrome-Related Cardiomyopathy is Associated with a Reduction in Myocardial Glucose Oxidation. (2021) (5)
Comparison of echocardiography and cardiac magnetic resonance imaging in the determination of left ventricular mass index in Fabry disease (2016) (5)
Gelsolin is an important mediator of Angiotensin II‐induced activation of cardiac fibroblasts and fibrosis (2021) (5)
Cardiac reverse remodelling and health status in patients with chronic heart failure (2021) (5)
Calcific bicuspid aortic valve disease in a patient with Cornelia de Lange syndrome: linking altered Notch signaling to aortic valve disease. (2006) (5)
Screening and Initiating Supportive Care in Patients With Heart Failure (2019) (5)
OS 36-07 TREATMENT WITH APELIN-13 PREVENTS PRESSURE OVERLOAD-INDUCED AORTIC ADVENTITIAL REMODELING AND FIBROSIS IN HYPERTENSIVE RATS WITH TAC (2016) (4)
Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators. (2021) (4)
Pharmacological and cell-specific genetic PI3Kα inhibition worsens cardiac remodeling after myocardial infarction. (2021) (4)
Role of Signaling Pathways in the Myocardial Response to Biomechanical Stress and in Mechanotransduction in the Heart (2010) (4)
Circulating troponin and further left ventricular ejection fraction improvement in patients with previously recovered left ventricular ejection fraction (2020) (4)
The dual nature of obesity in metabolic programming: quantity versus quality of adipose tissue. (2020) (4)
Role of autoimmunity in heart disease: is Chagas heart disease the definitive proof? (2014) (4)
Is &bgr;-Arrestin 2 a Magic Bullet for Heart Failure Treatment? (2017) (4)
Cardiac remodelling predicts outcome in patients with chronic heart failure (2021) (4)
Transcriptomic Signatures of End-Stage Human Dilated Cardiomyopathy Hearts with and without Left Ventricular Assist Device Support (2022) (3)
Urinary angiotensin-converting enzyme 2 and metabolomics in COVID-19-mediated kidney injury (2022) (3)
Letter by McLean and Oudit regarding article, "myostatin regulates energy homeostasis in the heart and prevents heart failure". (2015) (3)
3 – Voltage-Gated Potassium Channels (2018) (3)
Battle of the Sexes: Differential Prognosis by Sex in Dilated Cardiomyopathy. (2019) (3)
Beneficial Effects of Grape Resveratrol on Serum Adiponectin and Inflammation: Clinical Trial in Patients with Stable Coronary Artery Disease (2013) (3)
Sulfhydryl modulation of K+ currents: a possible cross-link between oxidative stress and altered cardiovascular function. (2003) (3)
Scleraxis and fibrosis in the pressure-overloaded heart. (2022) (3)
OS 36-07 TREATMENT WITH APELIN-13 PREVENTS PRESSURE OVERLOAD-INDUCED AORTIC ADVENTITIAL REMODELING AND FIBROSIS IN HYPERTENSIVE RATS WITH TAC. (2016) (3)
Resistant Hypertension From Renal Artery Stenosis Leading to Heart Failure With Preserved Ejection Fraction (2018) (3)
Clinical utility of 12‐lead electrocardiogram in evaluating heart disease in patients with muscular dystrophy: Assessment of left ventricular hypertrophy, conduction disease, and cardiomyopathy (2021) (3)
Abstract 15697: Acute Pharmacological Inhibition of PI3Kα by the Novel Cancer Drug, BYL-719, Has a Pro-arrhythmic Effect (2016) (3)
characterized by lipotoxicity and diastolic dysfunction with preserved (2009) (2)
Modulation of Cardiac Injury by ACE inhibitor/ARB in Patients with Severe COVID-19 (2020) (2)
Role of sex steroids and sexual dimorphism on cardiac iron metabolism in iron-overload cardiomyopathy. (2014) (2)
Review of Hydroxychloroquine Cardiotoxicity: Lessons From the COVID-19 Pandemic (2022) (2)
Mechanisms of Cardiac Arrhythmias: Molecular and Cellular Perspective (2014) (2)
Cardiovascular pathophysiology: is it a tumour necrosis factor superfamily affair? (2014) (2)
Quantification of pulmonary edema in heart failure using MRI: invasive validation and evaluation in HFpEF and HFrEF patients (2016) (2)
AJP MS # Revision 1 TRANSLATIONAL PHYSIOLOGY Angiotensin Converting Enzyme-2 (ACE2) confers endothelial protection and attenuates atherosclerosis (2008) (2)
Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 Diabetes (2022) (2)
Burden of Valvular Heart Disease in Patients with Fabry Disease. (2021) (2)
8D.01: EFFECTS OF ANGIOTENSIN-CONVERTING ENZYME 2 ON RENAL OXIDATIVE STRESS LEVELS IN APOLIPOPROTEIN E-DEFICIENT MICE (2015) (2)
Angiotensin Converting Enzyme 2 - at the Heart of the COVID-19 pandemic (2023) (2)
Testosterone and cardiac remodeling: why are older men susceptible to heart disease? (2019) (2)
NADPH oxidase subunit (2011) (2)
Loss of TIMP4 (Tissue Inhibitor of Metalloproteinase 4) Promotes Atherosclerotic Plaque Deposition in the Abdominal Aorta Despite Suppressed Plasma Cholesterol Levels (2021) (2)
ACE2 (Angiotensin-Converting Enzyme 2)-Mediated Protection From Pulmonary Hypertension: Lung-Gut Axis at Center Stage. (2020) (2)
Reduced native right ventricular T1 in Anderson-Fabry disease as compared to patients with pulmonary hypertension (2014) (2)
Modulation of Iron Uptake in Heart by L-Type Ca 2 (cid:49) Channel Modifiers Possible Implications in Iron Overload (1999) (2)
Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling (2015) (1)
Low Prevalence of Cardiomyopathy in Patients with Mitochondrial Disease and Neurological Manifestations (2022) (1)
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics (2021) (1)
Cardiogenic Shock With Takotsubo Syndrome vs Myocardial Infarction: Better Short-term Outcomes but Significant Long-term Risk and Need for Surveillance. (2019) (1)
Complexity of acute care journey of females with heart failure following hospitalization (2021) (1)
Adipose biology, cardiovascular, and cardiometabolic disease: novel insights and new targets for intervention. (2020) (1)
Regulators of G-Protein Signaling 10 and Heart Failure: The Importance of Negative Regulators of Heart Disease. (2016) (1)
Cancer Therapy-Related Hypertension: A Scientific Statement From the American Heart Association. (2023) (1)
Abstract 5264: Recombinant Human Angiotensin Converting Enzyme 2 Normalizes Blood Pressure and Reduces the Progression of Diabetic Nephropathy (2009) (1)
Predicting the Risk Factors Associated With Severe Outcomes Among COVID-19 Patients–Decision Tree Modeling Approach (2022) (1)
GW25-e1669 Apelin Treatment Enhances ACE2 expression and Attenuates Angiotensin II-Mediated Aortic Fibrosis in Apolipoprotein E-Deficient Mice (2014) (1)
Abstract 323: Acute Reduction of Ambient Air Pressure Lowers Systemic Vascular Resistance and Improves Cardiac Output in Mice in-vivo (2016) (1)
ACE2/Ang-(1–7) signaling and vascular remodeling (2014) (1)
Sickle cell disease, interleukin-18, and arrhythmias. (2021) (1)
Erratum to: Use of ginseng to reduce post-myocardial adverse myocardial remodeling: applying scientific principles to the use of herbal therapies (2013) (1)
Angiotensin II Induced Proteolytic Cleavage of Angiotensin Converting Enzyme 2 Is Mediated Via the Tnf-Alpha Converting Enzyme (TACE/ADAM-17): A Positive Feedback Mechanism in the Renin Angiotensin System (2013) (1)
Human recombinant angiotensin converting enzyme 2 reduces the progression of diabetic nephropathy (2009) (1)
Sarcoidosis: a prospective observational cohort from Northern Alberta (2020) (1)
545 Cardioprotective effects mediated by AT1 receptor blockade and enhancing ang 1-7 in experimental heart failure in ACE2-null mice (2011) (1)
Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice (2013) (1)
Abstract 13355: Loss of TIMP3 Leads to Adverse Remodeling of the Vascular Wall Structure and Development of Abdominal Aortic Aneurysm Following Angiotension II Treatment (2011) (1)
Abstract 11800: Inhibition of Pyruvate Dehydrogenase Kinase Does Not Improve Cardiac Abnormalities in a Mouse Model of Human Barth Syndrome (2021) (1)
491 Loss of Apelin exacerbates post-myocardial infarction remodeling and myocardial ischemia-reperfusion injury (2011) (1)
The ACE2/Ang (1–7) Pathway in Cardiac Remodeling Due to Pressure Overload (2013) (1)
Dual Loss of PI3Kα and PI3Kγ Leads to a Paradoxical Increase in AKT Activation and Physiological Hypertrophy (2010) (0)
Looking at the Right Side: Amenability of the Right Ventricle to Therapy in Titin-related Dilated Cardiomyopathy. (2021) (0)
Insulin-Like Growth Factor-1 and PTEN Deletion Enhance Cardiac L-type Ca 2 (cid:1) Currents via Increased PI3K (cid:2) /PKB Signaling (2006) (0)
Right ventricular remodeling and dysfunction among the spectrum of heart failure phenotypes (2016) (0)
The effects of Angiotensin-(1-7) /Mas/PI3K/Akt/NO axis in acute atrial tachycardia canine model and the possible role of atrial natriuretic peptide (2014) (0)
Abstract 18845: Left Ventricular Assist Device Normalizes Multiple Pathogenic Pathways in Both the Left and Right Ventricle in Patients With Dilated Cardiomyopathy (2014) (0)
Differential trajectories in LVEF predicts divergent clinical outcomes in HFrEF patients (2020) (0)
Myocardial iron depletion exacerbates end-stage heart failure by promoting adverse remodeling and worsening mitochondrial function (2020) (0)
Phosphatidylinositol 3-Kinase (cid:1) Is a Critical Mediator of Myocardial Ischemic and Adenosine-Mediated Preconditioning Integrative Physiology (2008) (0)
Abstract 12263: Loss of p47phox Subunit of NADPH Oxidase Enhances Susceptibility to Biomechanical Stress: Novel Role Of p47phox in the Regulation of Cortactin and Actin Filaments (2012) (0)
Signaling via PI3k(beta) and PI3K{gamma} and increased glucose oxidation contribute to the marked protection against ischemia/reperfusion injury in PI3K(alpha)dn hearts (2012) (0)
Reply to Letter From Floras et al.--Central Sleep Apnea: Risk Factor or Pathogenic Process in Patients With Heart Failure. (2016) (0)
PI3Kα Is Required for Recovery From Transient CRE/Tamoxifen Cardiotoxicity, but Is not Required for Normal Cardiac Function in the Adult Mouse Heart (2013) (0)
Reply: RAS Fingerprint. (2017) (0)
Abstract MP216: Identification Of Novel Phosphoprotein Signaling Pathways In Human Dilated Cardiomyopathy By Integrative Proteomic And Phosphoproteomic Analysis (2021) (0)
Caloric restriction limits fatty acid oxidation and improves cardiac function in heart failure associated with obesity (2018) (0)
Abstract 16452: Determinants of Vt Occurrence in Patients With Nonischemic and Dilated Cardiomyopathy: Insights From the Study of Explanted Human Hearts (2014) (0)
281 Angiotensin converting enzyme 2 (ACE2)deficiency results in endothelial dysfunction and worsens diabetic cardiomyopathy (2011) (0)
Processes for Longitudinal Care of Sarcoidosis in Northern Alberta (2017) (0)
Renin-Angiotensin System (RAS) in Hematopoietic Stem/Progenitor Cells (HS/PC) Predicts Vaso-reparative Dysfunction and Progression of Diabetic Retinopathy (DR) (2017) (0)
Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway (2022) (0)
Cytotoxic aldehydes aggravate ventricular dysfunction in an injured heart: evidence from an iron overload model of heart failure (2002) (0)
PLASMA BIOMARKER ANALYSIS IN PATIENTS WITH CARDIOMYOPATHY SECONDARY TO FABRY DISEASE : INSIGHT INTO THE PATHOPHYSIOLOGY OF FABRY CARDIOMYOPATHY (2014) (0)
Stress-induced ST segment elevation occurs predominantly in men: A clue to the gender-bias puzzle in coronary artery disease testing? (1997) (0)
Discovery and analyses of pathogenic variants in explanted hearts from primary cardiomyopathy patients (2020) (0)
The Role of PI3K Isoforms and Sarcolemmal KATP Channel in Epoxyeicosatrienoic Acid Mediated Cardioprotection (2011) (0)
GW27-e0379 Apelin attenuates aortic adventitial fibrosis in spontaneously hypertensive rats through modulating miR-1 and beta-catenin signaling (2016) (0)
Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm (2014) (0)
Abstract 8299: Loss of Apelin Exacerbates Post-Myocardial Infarction Remodeling and Myocardial Ischemia-Reperfusion Injury (2011) (0)
SUPPORTIVE CARE IN HEART FAILURE: ESTABLISHING A NEW INTEGRATIVE CARE INITIATIVE (2019) (0)
PATIENTS WITH MITRAL REGURGITATION ARE NOT MORE LIKELY TO RESPOND TO CARDIAC RESYNCHRONIZATION THERAPY (2015) (0)
Impact of The Protective Renin-Angiotensin System (RAS) on The Vasoreparative Function of CD34+ CACs in Diabetic Retinopathy (2016) (0)
Abstract 16333: PI3Kα Has a Role in Myocardial Insulin Signaling and Recovery From Cre/Tamoxifen Cardiotoxicity, but is not Required for Normal Function in the Adult Mouse Heart (2014) (0)
1040 ANGIOTENSIN II-MEDIATED VASCULAR INFLAMMATION IS ACCELERATED IN ACE2 NULL MICE WITH ENHANCED PROFILIN-1 EXPRESSION (2012) (0)
SARS-CoV-2 infection downregulates myocardial ACE2 and potentiates cardiac inflammation in humans and hamsters (2022) (0)
Abstract 656: Construction and Application of an Epigenetic Atlas of the Human Heart (2019) (0)
Angiotensin Converting Enzyme 2 Deficiency Exacerbates Angiotensin II Induced Loss of Smooth Muscle Cells Leading to Enhanced Adverse Vascular Remodeling (2013) (0)
Review Article PI3K Inhibitors as Novel Cancer Therapies: Implications for Cardiovascular Medicine (2013) (0)
Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease (2014) (0)
ANGIOTENSIN II-MEDIATED MYOCARDIAL EXPRESSION OF MMP2, MMP9 AND MT1-MMP WERE ENHANCED IN ACE2-NULL MICE (2012) (0)
Atrophy , and Dilated Cardiomyopathy Mitochondrial Dysfunction , Skeletal Muscle Apoptosis-Inducing Factor Leads to Muscle-Specific Loss of (2005) (0)
GW24-e3625 Effects of apelin on the phosphodiesterase 1 expression and oxidative stress levels in mouse kidney fibroblast cells (2013) (0)
Cardiac Sarcoplasmic Reticulum Calcium Release and Load Are Enhanced by Subcellular cAMP Elevations in PI3K (cid:1) -Deficient Mice Cellular Biology (2005) (0)
PREVENTION OF PRESSURE OVERLOAD-INDUCED MYOCARDIAL FIBROSIS AND PATHOLOGICAL REMODELING BY ANGIOTENSIN CONVERTING ENZYME 2: 4C.07 (2011) (0)
CHARACTERIZATION OF CELLULAR INFILTRATE IN BIOPROSTHETIC AORTIC AND MITRAL VALVES (2018) (0)
Role of angiotensin peptides in risk stratification and prognostication for heart failure: focus on plasma Ang 1–7/Ang II ratio (2020) (0)
Response to ‘Angiotensin-converting enzyme 2 (ACE2) gene and protein expression in diabetic patients without nephropathy’ (2009) (0)
Prevention of angiotensin II-induced hypertension and cardiac remodeling by recombinant human angiotensin-converting enzyme 2 in mice (2009) (0)
SP024MURINE RECOMBINANT ACE2 ATTENUATES KIDNEY INJURY IN EXPERIMENTAL ALPORTS SYNDROME (AS) (2015) (0)
PI 3 K a Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction (2019) (0)
BASELINE LEFT VENTRICULAR CONTRACTILE STATE IS THE STRONGEST DETERMINANT OF FUTURE DROPS IN EJECTION FRACTION FROM CARDIOTOXIC CHEMOTHERAPY: A MACHINE LEARNING BASED CMR STUDY (2022) (0)
Trajectory of left ventricular ejection fraction in response to therapies in patients with muscular dystrophy (2022) (0)
Antagonism of angiotensin 1–7 prevents the therapeutic effects of recombinant human ACE2 (2015) (0)
Cells of the adult human heart (2020) (0)
GW28-e0806 Pyr1-Apelin 13 is a negative modulator of angiotensin II-mediated adverse myocardial hypertrophy, remodeling and fibrosis (2017) (0)
PI3K alpha Deletion in Cardiomyocytes Causes Maintained Mitochondrial Membrane Potential and Blocks Necrotic Cell Death in Ischemia/Reperfusion Injury (2016) (0)
and Implications in Iron Overload Channel Modifiers : Possible 2 + Modulation of Iron Uptake in Heart by L-Type Ca (1999) (0)
Human Embryonic Stem Cells : Therapeutic Implications Electrophysiological Profiling of Cardiomyocytes in Embryonic Bodies Derived From (2013) (0)
Abstract 80: PI3Kα Regulates Biomechanical Stress-induced Cytoskeletal Remodeling: A Critical Role of Gelsolin (2016) (0)
Abstract 13519: Signaling via PI3Kβ and PI3Kγ and Increased Glucose Oxidation Contribute to the Marked Protection Against Ischemia/Reperfusion Injury in PI3KαDN Hearts (2012) (0)
Use of Serial High-Sensitive Troponin T in Patients With Adult Congenital Heart Disease: Enhancing the Detection of Major Adverse Cardiac Events. (2020) (0)
Distinctive Functions of PI3K beta in Endothelial Cells and Cardiomyocytes in Response to Myocardial Infarction: Complications for Targeting PI3K beta in Myocardial Infarction Treatment (2016) (0)
Correlates of stress-induced 201Tl reversibility vary according to ST segment response (1997) (0)
GW26-e3978 Regulatory roles of Angiotensin-Converting Enzyme 2 in NOX4 Expression and Oxidative Stress Levels in Kidneys of Apolipoprotein E-Deficient Mice (2015) (0)
Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury (2012) (0)
Loss of ACE2 Accelerates Pressure Overload-Induced Myocardial Oxidative Stress and Ventricular Dysfunction (2010) (0)
Abstract 17850: Elevated Inflammatory Plasma Biomarkers in Patients With Anderson-Fabry Disease: A Critical Link to Heart Failure With Preserved Ejection Fraction (2016) (0)
UROSELECTIVE ALPHA-1 BLOCKERS IN MALES WITH HEART FAILURE: NESTED CASE-CONTROL STUDY (2022) (0)
Abstract P1-03-07: Breast cancer diagnosis is associated with relative left ventricular hypertrophy (2019) (0)
GW25-e1527 Cardioprotective Effects of Angiotensin-Converting Enzyme 2 in Apolipoprotein E-Deficient Mice in Response to Angiotensin II (2014) (0)
Abstract 16611: Impact of Mechanical Unloading on Structural and Non-structural Components of the Extracellular Matrix in Patients With Dilated Cardiomyopathy (2015) (0)
Stable Interatrial Communication Combining Balloon Atrial Septostomy and Radiofrequency Catheter Ablation (2018) (0)
Proteomics and phosphoproteomics of failing human left ventricle identifies dilated cardiomyopathy-associated phosphorylation of CTNNA3. (2023) (0)
A Male-Specific mRNA Panel Improves Differentiation between Heart Failure with Reduced and Preserved Ejection Fraction (2014) (0)
Abstract 19196: Resveratrol Prevents the Oxidative Stress and Diastolic Dysfunction in Iron-overload Cardiomyopathy (2012) (0)
Corrigendum: Dendritic cell–induced autoimmune heart failure requires cooperation between adaptive and innate immunity (2004) (0)
Haploinsufficiency of ACE2 Is Sufficient to Enhance Susceptibility to Heart Failure With Adverse Cardiovascular Remodeling (2013) (0)
Abstract 18964: Resveratrol Prevents Iron-overload Cardiomyopathy by up Regulating Serca2a and by Exerting Anti-oxidant Effects (2014) (0)
Distinct remodeling pattern between pediatric and adult heart failure: a focus on Ca2+ signaling pathway at proteomic level (2020) (0)
ACE2 is a negative regulator of profilin-1 expression and collagen production in cultured adult murine cardiomyocytes (2011) (0)
The novel reninangiotensin system, inflammation and hypertension (2013) (0)
Mechanism of Iron-Overload Cardiomyopathy-Selective Diastolic Dysfunction Associated With Oxidative Stress Mediated Ca2+ Cycling Defects: Prevention With Resveratrol Dietary Intervention (2013) (0)
Abstract 18956: Loss of Gelsolin Attenuates Pressure Overload Induced Heart Failure: Novel Role of Gelsolin in Cardiac Biomechanical Stress Induced Cytoskeletal Remodeling (2014) (0)
Abstract 10878: Angiotensin Converting Enzyme 2 (ACE2) Deficiency Activates NADPH Oxidase Resulting in Endothelial Dysfunction and Worsens Diabetic Cardiomyopathy (2011) (0)
Erratum to: Use of ginseng to reduce post-myocardial adverse myocardial remodeling: applying scientific principles to the use of herbal therapies (2013) (0)
Abstract 385: Characterization of Cellular Infiltrate in Bioprosthetic Aortic and Mitral Valves (2018) (0)
Progression of left ventricular mass (LVM) is associated with clinical events in Fabry disease: Analyses from Fabry Registry (2023) (0)
Abstract 19266: Renin-Angiotensin Axis in Hematopoietic Stem/Progenitor Cells Predicts Vascular Dysfunction and Diabetic Retinopathy (2016) (0)
Abstract 988: Tissue Inhibitor Of Metalloproteinase-3 Regulates Myocardial Fibrosis By Regulating The TGF{beta}-TNF Interaction (2007) (0)
Novel ACTA1 Mutation in a Family with Congenital Myopathy and Variably-penetrant Cardiomyopathy (P6-8.008) (2023) (0)
Abstract 18910: Angiotensin Converting Enzyme 2 Deficiency Results in Cardiac Insulin Resistance in Response to High-Fat Diet (2014) (0)
Abstract 14440: PI3Kα Deletion in Cardiomyocytes Causes Maintained Mitochondrial Membrane Potential and Blocks Necrotic Cell Death in Ischemia/Reperfusion Injury (2016) (0)
291 Angiotensin II induces diastolic dysfunction via the AT1 receptor with a reduction in carbohydrate oxidation caused by up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) (2011) (0)
1039 ACE2 DEFICIENCY FACILIATES ANGIOTENSIN II-MEDIATED VASCULAR PEROXYNITRITE PRODUCTION WITH ACTIVATION OF THE AKT/ENOS SIGNALING (2012) (0)
Abstract 13474: PI3K{alpha} is Required for Recovery from Transient Cre/tamoxifen Induced Cardiotoxicity (2012) (0)
The Role of Neurohumoral Activation in Cardiac Fibrosis and Heart Failure (2015) (0)
Abstract 16253: Distinctive Functions of PI3Kβ in Endothelial Cells and Cardiomyocytes in Response to Myocardial Infarction: Complications for Targeting PI3Kβ in Myocardial Infarction Treatment (2016) (0)
Effects of age, gender, and risk-factors for heart failure on native myocardial T1 and extracellular volume fraction using the SASHA sequence at 1.5T (2018) (0)
Integrating Cardiac MRI Imaging and Multidisciplinary Clinical Care is associated with Improved Outcomes in Patients with Fabry Disease.: Improving clinical outcomes in patients with Fabry Disease. (2022) (0)
Remodeling of myocardial extracellular matrix and proteoglycans varies in pediatric versus adult patients with dilated cardiomyopathy (2018) (0)
Persistent myopericarditis after heterologous SARS-CoV-2 mRNA vaccination (2023) (0)
Reply to Letter from Dzwiniel et al.—Making a Clinical Diagnosis of CPVT: Putting It All Together (2012) (0)
148 Loss of TIMP3 leads to adverse remodeling of the vascular wall structure and development of Abdominal Aortic Aneurysm following angiotensin II treatment (2011) (0)
Cardiac manifestations and clinical management of X-linked Emery-Dreifuss muscular dystrophy: a case series (2023) (0)
Combination of TNF (cid:1) Ablation and MMP Inhibition Prevents Heart Failure After Pressure Overload in TIMP-3 Mutant Mice (2005) (0)
Walking or vigorous exercise? Which best helps prevent coronary heart disease in women? (2000) (0)
A1156 Cardioprotective effects of Apelin-13 on aging- and angiotensin II-mediated adverse myocardial injury and dysfunction in hypertensive mice (2018) (0)
Myocardial adipose triglyceride lipase over-expression improves systolic function and protects against pressure overload-induced cardiac dysfunction (2011) (0)
P1267Empagliflozin prevention of heart failure development in diabetes is associated with an improvement in cardiac energy producition (2018) (0)
Biomarkers of Diastolic and Systolic Heart Failure (2013) (0)
Evaluating the diagnostic and prognostic value of cardiac biomarkers for heart disease and major adverse cardiac events in patients with muscular dystrophy (2020) (0)
Loss of PI3Kγ Enhances cAMP-Dependent MMP Remodeling of N-Cadherin Adhesion Complexes and Extracellular Matrix in Response to Biomechanical Stress (2010) (0)
Role of Epicardial Adipose Tissue in Heart Failure: From Basic to Clinical Perspectives (2020) (0)
Inhibition of Calcineurin and Sarcolemmal Ca 2 (cid:1) Influx Protects Cardiac Morphology and Ventricular Function in K v 4.2N Transgenic Mice (2002) (0)

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