Gebhard Schertler
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Physics
Gebhard Schertler's Degrees
- PhD Physics ETH Zurich
- Masters Physics University of Zurich
- Bachelors Physics University of Zurich
Why Is Gebhard Schertler Influential?
(Suggest an Edit or Addition)Gebhard Schertler's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Crystal structure of the human β2 adrenergic G-protein-coupled receptor (2007) (1579)
- Molecular signatures of G-protein-coupled receptors (2013) (1299)
- Structure of a β1-adrenergic G-protein-coupled receptor (2008) (1200)
- Projection structure of rhodopsin (1993) (739)
- Structure of bovine rhodopsin in a trigonal crystal form. (2003) (734)
- The structural basis for agonist and partial agonist action on a β1-adrenergic receptor (2010) (617)
- An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors. (1997) (599)
- Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. (2007) (500)
- The structural basis of agonist-induced activation in constitutively active rhodopsin (2011) (466)
- Structure of the μ Opioid Receptor-Gi Protein Complex (2018) (416)
- Arrangement of rhodopsin transmembrane α-helices (1997) (406)
- A three-dimensional movie of structural changes in bacteriorhodopsin (2016) (308)
- Electron crystallography reveals the structure of metarhodopsin I (2004) (290)
- Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy. (1995) (257)
- Crystal structure of a thermally stable rhodopsin mutant. (2007) (241)
- Tracking G-protein-coupled receptor activation using genetically encoded infrared probes (2010) (237)
- Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region (2016) (232)
- Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser (2018) (221)
- New G-protein-coupled receptor crystal structures: insights and limitations. (2008) (221)
- Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II (2011) (220)
- Projection structure of frog rhodopsin in two crystal forms. (1995) (215)
- Two distinct conformations of helix 6 observed in antagonist-bound structures of a β1-adrenergic receptor (2011) (200)
- Engineering G protein-coupled receptors to facilitate their structure determination. (2009) (184)
- Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons (2017) (178)
- Lipidic cubic phase serial millisecond crystallography using synchrotron radiation (2015) (173)
- The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor (2014) (167)
- Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor (2016) (140)
- Structure of the mu-opioid receptor-Giprotein complex. (2018) (138)
- Arrangement of rhodopsin transmembrane alpha-helices. (1997) (123)
- Development of an antibody fragment that stabilizes GPCR/G-protein complexes (2018) (113)
- Protein crystallography microdiffraction. (2005) (107)
- The structure of bacteriorhodopsin and its relevance to the visual opsins and other seven-helix G-protein coupled receptors. (1990) (106)
- Development and crystallization of a minimal thermostabilised G protein-coupled receptor. (2009) (104)
- Overproduction of membrane proteins (1992) (99)
- Orthorhombic crystal form of bacteriorhodopsin nucleated on benzamidine diffracting to 3.6 A resolution. (1993) (98)
- Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A (2013) (96)
- Characterisation of an improved two-dimensional p22121 crystal from bovine rhodopsin. (1998) (88)
- Expression and purification of truncated, non-glycosylated turkey beta-adrenergic receptors for crystallization. (2003) (87)
- Protein crystallography with a micrometre-sized synchrotron-radiation beam (2008) (85)
- Insights into congenital stationary night blindness based on the structure of G90D rhodopsin (2013) (82)
- Structure of rhodopsin and the metarhodopsin I photointermediate. (2005) (80)
- Femtosecond X-ray diffraction from two-dimensional protein crystals (2014) (76)
- Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography. (2015) (71)
- Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography (2016) (71)
- Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation (2019) (70)
- Three-dimensional structure of an invertebrate rhodopsin and basis for ordered alignment in the photoreceptor membrane. (2001) (68)
- Femtosecond-to-millisecond structural changes in a light-driven sodium pump (2020) (68)
- Projection structure of an invertebrate rhodopsin. (1996) (62)
- Crystals of native and modified bovine rhodopsins and their heavy atom derivatives. (2004) (59)
- Two alternative conformations of a voltage-gated sodium channel. (2013) (58)
- Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC. (2004) (55)
- Structure of rhodopsin (1998) (51)
- Molecular architecture of a retinal cGMP‐gated channel: the arrangement of the cytoplasmic domains (2002) (50)
- The Three-dimensional Structure of Bovine Rhodopsin Determined by Electron Cryomicroscopy* (2003) (50)
- Recoverin Binds Exclusively to an Amphipathic Peptide at the N Terminus of Rhodopsin Kinase, Inhibiting Rhodopsin Phosphorylation without Affecting Catalytic Activity of the Kinase* (2006) (49)
- Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity (2018) (49)
- Probing Gαi1 protein activation at single–amino acid resolution (2015) (47)
- Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis. (2016) (47)
- Conserved activation pathways in G-protein-coupled receptors. (2012) (47)
- Production of GPCR and GPCR complexes for structure determination. (2013) (43)
- Membrane protein structural biology using X-ray free electron lasers. (2015) (43)
- Chromophore motion during the bacteriorhodopsin photocycle: polarized absorption spectroscopy of bacteriorhodopsin and its M‐state in bacteriorhodopsin crystals. (1991) (42)
- Faculty Opinions recommendation of Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). (2011) (42)
- Perspective: Opportunities for ultrafast science at SwissFEL (2017) (39)
- GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014 (2015) (35)
- 7 Å resolution in protein two-dimensional-crystal X-ray diffraction at Linac Coherent Light Source (2014) (35)
- Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding. (2013) (35)
- Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR (2019) (30)
- Ligand channel in pharmacologically stabilized rhodopsin (2018) (29)
- Crystal structure of the human b 2 adrenergic G-protein-coupled receptor (2007) (29)
- Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit (2019) (29)
- Early peak and rapid decline of SARS-CoV-2 seroprevalence in a Swiss metropolitan region (2020) (28)
- Signal transduction: The rhodopsin story continued (2008) (27)
- Rhodopsin photoproducts in 2D crystals. (2004) (27)
- Molecular mechanism of phosphorylation-dependent arrestin activation. (2014) (27)
- Structural role of the T94I rhodopsin mutation in congenital stationary night blindness (2016) (27)
- Preparation and analysis of two-dimensional crystals of rhodopsin. (2000) (25)
- Time-resolved structural studies with serial crystallography: A new light on retinal proteins (2015) (24)
- Crystallization Scale Preparation of a Stable GPCR Signaling Complex between Constitutively Active Rhodopsin and G-Protein (2014) (22)
- Structure of rhodopsin. (2007) (22)
- Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist (2020) (20)
- Preparation of an activated rhodopsin/transducin complex using a constitutively active mutant of rhodopsin. (2011) (18)
- Structure of the µ-opioid receptor–Gi protein complex (2018) (17)
- A graph-based approach identifies dynamic H-bond communication networks in spike protein S of SARS-CoV-2 (2020) (16)
- Advances in long-wavelength native phasing at X-ray free-electron lasers (2020) (16)
- The counterion–retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation (2019) (15)
- X-ray diffraction of heavy-atom labelled two-dimensional crystals of rhodopsin identifies the position of cysteine 140 in helix 3 and cysteine 316 in helix 8. (2002) (15)
- Dynamics and mechanism of a light-driven chloride pump (2022) (14)
- Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish (2018) (14)
- Adaptation of pineal expressed teleost exo-rod opsin to non-image forming photoreception through enhanced Meta II decay (2011) (13)
- Complete Reversible Refolding of a G-Protein Coupled Receptor on a Solid Support (2016) (13)
- Batch crystallization of rhodopsin for structural dynamics using an X-ray free-electron laser (2015) (13)
- The Two-Photon Reversible Reaction of the Bistable Jumping Spider Rhodopsin-1 (2019) (12)
- Rhodopsin photointermediates in two-dimensional crystals at physiological temperatures. (2006) (10)
- Spial: analysis of subtype-specific features in multiple sequence alignments of proteins (2010) (9)
- Ligands stabilize specific GPCR conformations: but how? (2012) (9)
- The counterion–retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation (2019) (9)
- The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods (2021) (8)
- Structure of β-adrenergic receptors. (2013) (8)
- Soluble dimeric prion protein ligand activates Adgrg6 receptor but does not rescue early signs of demyelination in PrP-deficient mice (2020) (8)
- Retinal proteins - you can teach an old dog new tricks. (2014) (8)
- Projection structure of a transcriptional regulator, HupR, determined by electron cryo-microscopy. (2000) (7)
- Arrestin-1 engineering facilitates complex stabilization with native rhodopsin (2019) (7)
- Structure of rhodopsin as a G protein-coupled receptor (2005) (7)
- Structural basis of the partially open central gate in the human CNGA1/CNGB1 channel explained by additional density for calmodulin in cryo-EM map. (2021) (7)
- A set of common movements within GPCR-G-protein complexes from variability analysis of cryo-EM datasets (2020) (6)
- The role of water molecules in phototransduction of retinal proteins and G protein-coupled receptors. (2017) (6)
- C-Graphs Tool with Graphical User Interface to Dissect Conserved Hydrogen-Bond Networks: Applications to Visual Rhodopsins (2021) (6)
- Rhodopsin on tracks: new ways to go in signaling. (2015) (6)
- New Insights into Arrestin Recruitment to GPCRs (2020) (5)
- High-mass MALDI-MS unravels ligand-mediated G protein–coupling selectivity to GPCRs (2021) (5)
- GPCR Activation States Induced by Nanobodies and Mini-G Proteins Compared by NMR Spectroscopy (2020) (5)
- Photocrosslinking between nucleic acids and proteins: general discussion. (2018) (5)
- mosquito[reg] LCP: Making membrane protein crystallization accessible to the research scientist (2011) (5)
- Structural role of the T 94 I rhodopsin mutation in congenital stationary night blindness (2016) (4)
- Efficient production of a functional G protein-coupled receptor in E. coli for structural studies (2021) (4)
- Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region (2023) (3)
- "4D Biology for health and disease" workshop report. (2011) (3)
- Large scale expression and purification of the rat 5-HT2c receptor. (2015) (2)
- Exploring the signaling space of a GPCR using bivalent ligands with a rigid oligoproline backbone (2021) (2)
- Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons (2017) (2)
- Addendum to “Three-dimensional mass density mapping of cellular ultrastructure by ptychographic X-ray nanotomography” [J. Struct. Biol. 192 (2015) 461–469] (2016) (2)
- Immobilization of arrestin-3 on different biosensor platforms for evaluating GPCR binding. (2020) (2)
- Rhodopsin Photoproducts in 2 D Crystals (2004) (2)
- Crystal structure of the human beta2 adrenoceptor (2007) (2)
- mosquito ® LCP : Making membrane protein crystallization accessible to the research scientist mosquito ® (2011) (2)
- Electron Crystallographic Studies of Rhodopsin (2002) (2)
- Cryo-EM structure of the rhodopsin-G alpha i-beta gamma complex reveals binding of the rhodopsin C-terminal tail to the G beta subunit. (2019) (1)
- Ultrafast structural changes direct the first molecular events of vision (2022) (1)
- dimensional-crystal X-ray diffraction at Linac Coherent Light Source (2015) (1)
- Three dimensional structure of rhodopsin obtained by electron cryo-microscopy (1996) (1)
- Imaging of retina cellular and subcellular structures using ptychographic hard X-ray tomography. (2021) (1)
- Comprehensive Analysis of the Role of Arrestin Residues in Receptor Binding (2017) (1)
- Dimeric prion protein ligand activates Adgrg6 but does not rescue myelinopathy of PrP-deficient mice (2020) (1)
- CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN A RECEPTOR-BINDING DOMAIN IN COMPLEX WITH THE LUMINAL DOMAIN Of SV2C (2013) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL (2008) (0)
- Retinal isomerization in bacteriorhodopsin revealed by a femtosecond X-ray laser: 457-646 fs state structure (2018) (0)
- Retinal isomerization in bacteriorhodopsin revealed by a femtosecond X-ray laser: 8.3 ms state structure (2018) (0)
- Femtosecond to millisecond structural changes in a light-driven sodium pump: 30us+150us structure of KR2 with extrapolated, light and dark datasets (2020) (0)
- Table of Contents (1991) (0)
- Retinal isomerization in bacteriorhodopsin revealed by a femtosecond X-ray laser: resting state structure (2018) (0)
- Viral and Microbial Threats - a joint position paper by Analytical Research Infrastructures of Europe (ARIE) (2020) (0)
- Faculty Opinions recommendation of CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells. (2011) (0)
- Femtosecond-to-millisecond structural changes in a light-driven sodium pump (2020) (0)
- Correction of rhodopsin serial crystallography diffraction intensities for a lattice-translocation defect (2023) (0)
- Protein crystallization at the Laboratory of Molecular Biology: robotics, procedures and developments (2008) (0)
- Randomness in time-resolved serial crystallography data: alternatives to the binning and averaging approach (2022) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL (2011) (0)
- GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014 (2015) (0)
- Structure of thaumatin determined at SwissFEL using native-SAD at 4.57 keV from 20,000 diffraction patterns (2020) (0)
- Antibody FAB fragment targeting Gi protein heterotrimer (2019) (0)
- Figures and figure supplements Cryo-EM structure of the rhodopsin-G a i-bg complex reveals binding of the rhodopsin C-terminal tail to the g b subunit (2019) (0)
- cryo-EM structure of the NavCt voltage-gated sodium channel (2013) (0)
- Monomeric Wild Type And Constitutively Active Rhodopsin Is Effectively Phosphorylated By Different Grks And Binds Arrestin-1 (2012) (0)
- Dynamics retrieval from stochastically weighted incomplete data by low-pass spectral analysis (2022) (0)
- Structure of thaumatin determined at SwissFEL using native-SAD at 4.57 keV from all available diffraction patterns (2020) (0)
- Rhodopsin-Gi protein complex (2019) (0)
- Crystal Structure of T94I rhodopsin mutant (2016) (0)
- CRYSTAL STRUCTURE OF THE CONSTITUTIVELY ACTIVE E113Q,D2C,D282C RHODOPSIN MUTANT WITH BOUND GALPHACT PEPTIDE. (2011) (0)
- Rhodopsin Photointermediates in 2D Crystals at Physiological Temperatures (2008) (0)
- Structure of the A2A adenosine receptor determined at SwissFEL using native-SAD at 4.57 keV from all available diffraction patterns (2020) (0)
- Structure of thaumatin determined at SwissFEL using native-SAD at 6.06 keV from 50,000 diffraction patterns (2020) (0)
- Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel. (2023) (0)
- 1P036 Two alternative conformations of a voltage-gated sodium channel(01B. Protein:Structure & Function,Poster) (2013) (0)
- Light induced charge and energy transport in nucleic acids and proteins: general discussion. (2018) (0)
- Purification and Characterization of an Activated Rhodopsin/Transducin Complex (2009) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST ISOPRENALINE (2011) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB102) (2011) (0)
- Retinal isomerization in bacteriorhodopsin revealed by a femtosecond X-ray laser: 49-406 fs state structure (2018) (0)
- Night blindness causing G90D rhodopsin in complex with GaCT2 peptide (2013) (0)
- Femtosecond to millisecond structural changes in a light-driven sodium pump: 20ms structure of KR2 with extrapolated, light and dark datasets (2020) (0)
- Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells (2007) (0)
- Crystal structure of the light-activated constitutively active N2C, M257Y,D282C rhodopsin mutant in complex with a peptide resembling the C-terminus of the Galpha-protein subunit (GaCT) (2012) (0)
- Positional Effects of the Phosphorylated C-terminus of Rhodopsin on Arrestin Activation (2008) (0)
- Ultrafast structural changes direct the first molecular events of retinal isomerisation and rhodopsin activation. (2023) (0)
- Structure of the A2A adenosine receptor determined at SwissFEL using native-SAD at 4.57 keV from 50,000 diffraction patterns (2020) (0)
- Night blindness causing G90D rhodopsin in the active conformation (2013) (0)
- Room temperature structure of bacteriorhodopsin from lipidic cubic phase obtained with serial millisecond crystallography using synchrotron radiation (2015) (0)
- Arrestin-1 engineering facilitates complex stabilization with native rhodopsin (2019) (0)
- The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods (2021) (0)
- Protein crystallization: robotics, procedures and developments (2009) (0)
- Electrons and X-Rays Reveal the Structure of Rhodopsin: A Prototypical G Protein-Coupled Receptor-Implications for Colour Vision (2003) (0)
- High resolution structure of xylanase-II from one micron beam experiment (2008) (0)
- The adhesion GPCR Adgrd1 is a prion protein receptor and a mediator of prion cytotoxicity (2023) (0)
- Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound (2014) (0)
- Excited State Structural Dynamics of Retinal Isomerization Revealed by a Femtosecond X-Ray Laser (2018) (0)
- Structure of TolC in complex with hexamminecobalt (2004) (0)
- The greasy world of membrane proteins (1995) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL (2011) (0)
- Crystal structure of the rhodopsin-mini-Go complex (2018) (0)
- Structure of thaumatin determined at SwissFEL using native-SAD at 6.06 keV from all available diffraction patterns (2020) (0)
- Retinal isomerization in bacteriorhodopsin revealed by a femtosecond X-ray laser: 10 ps state structure (2018) (0)
- Development of an antibody fragment that stabilizes GPCR/G-protein complexes (2018) (0)
- Faculty of 1000 evaluation for Chemical and genetic engineering of selective ion channel-ligand interactions. (2012) (0)
- Bacteriorhodopsin ground state structure obtained with Serial Femtosecond Crystallography (2016) (0)
- Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation (2019) (0)
- G Protein-Coupled Receptor Activation Based on X-ray Structural Studies (2013) (0)
- Membrane Protein Crystallization (2020) (0)
- Crystal Structures of the 2 -Adrenergic Receptor (2009) (0)
- TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST SALBUTAMOL (2011) (0)
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