George Yancopoulos

George Yancopoulos's AcademicInfluence.com Rankings

George Yancopoulos

Biology

#1199

World Rank

#2037

Historical Rank

#616

USA Rank

Biochemistry

#282

World Rank

#347

Historical Rank

#122

USA Rank

biology Degrees

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Biology

George Yancopoulos's Degrees

PhD Microbiology and Immunology Columbia University
Doctorate Ophthalmology Columbia University

Why Is George Yancopoulos Influential?

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According to Wikipedia, George D. Yancopoulos is a Greek-American biomedical scientist who is the co-founder, president and chief scientific officer of Regeneron Pharmaceuticals. Yancopoulos is the holder of more than 100 patents. He is a principal inventor and developer of Regeneron's ten FDA-approved or -authorized treatments, as well as of Regeneron's foundational technologies for target and drug development, such as its proprietary TRAP technology, and the VelociGene and VelocImmune antibody technologies.

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George Yancopoulos's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Vascular-specific growth factors and blood vessel formation (2000) (3754)
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. (1997) (3529)
Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy (2001) (3174)
Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis (1996) (2884)
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo (2001) (2476)
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. (1999) (2208)
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning (1996) (1993)
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. (2012) (1883)
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF (1991) (1788)
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. (2004) (1777)
VEGF-Trap: A VEGF blocker with potent antitumor effects (2002) (1631)
Regulation of the Germinal Center Response by MicroRNA-155 (2007) (1553)
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways (2001) (1524)
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra (1991) (1469)
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. (1999) (1393)
Angiopoietin-1 protects the adult vasculature against plasma leakage (2000) (1295)
NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression (1990) (1259)
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 (2006) (1229)
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19 (2020) (1207)
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis. (2016) (1154)
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007) (1116)
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells (2006) (1084)
Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies (2020) (1056)
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. (2014) (1041)
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. (2002) (1012)
Dupilumab Efficacy and Safety in Moderate‐to‐Severe Uncontrolled Asthma (2018) (1009)
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail (2020) (981)
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. (2008) (959)
Essential role for oncogenic Ras in tumour maintenance (1999) (913)
Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis (1996) (883)
The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo (1996) (871)
Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab (2012) (860)
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis (2006) (860)
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. (1999) (837)
Increased vascularization in mice overexpressing angiopoietin-1. (1998) (808)
PD‐1 Blockade with Cemiplimab in Advanced Cutaneous Squamous‐Cell Carcinoma (2018) (807)
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF (1999) (802)
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor (1991) (801)
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. (1999) (794)
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. (2008) (784)
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. (1994) (763)
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting (2007) (750)
A BDNF autocrine loop in adult sensory neurons prevents cell death (1995) (732)
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. (2004) (726)
Ordered rearrangement of immunoglobulin heavy chain variable region segments. (1984) (721)
Intravitreal aflibercept for diabetic macular edema. (2014) (721)
Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial (2016) (713)
Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. (1992) (705)
Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. (1998) (704)
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases (1995) (704)
Intravitreal aflibercept injection for neovascular age-related macular degeneration: ninety-six-week results of the VIEW studies. (2014) (686)
CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130 (1992) (677)
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments (1985) (667)
Dupilumab in persistent asthma with elevated eosinophil levels. (2013) (667)
Agrin Acts via a MuSK Receptor Complex (1996) (658)
Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial (2017) (656)
Efficacy and Safety of Dupilumab in Glucocorticoid‐Dependent Severe Asthma (2018) (654)
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. (1993) (644)
Multiple knockout mouse models reveal lincRNAs are required for life and brain development (2013) (637)
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. (2007) (632)
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine (2012) (623)
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines (1984) (611)
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. (2004) (607)
Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial. (2016) (596)
Development of the primary antibody repertoire. (1987) (582)
The Knockout Mouse Project (2004) (574)
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands (1996) (540)
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease (2017) (537)
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells (1984) (528)
Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. (2008) (527)
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. (1997) (514)
Differential expression of myc family genes during murine development (1986) (513)
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells (1993) (511)
VEGF-initiated blood-retinal barrier breakdown in early diabetes. (2001) (511)
Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions (2000) (509)
Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone (2000) (500)
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis (2003) (492)
PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands (1998) (487)
Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (1999) (482)
Insulin-like Growth Factor-1 (IGF-1) Inversely Regulates Atrophy-induced Genes via the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Pathway* (2005) (476)
Angiopoietin-1 induces sprouting angiogenesis in vitro (1998) (475)
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations (2015) (464)
Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials (2019) (454)
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial (2016) (452)
Chemotactic Properties of Angiopoietin-1 and -2, Ligands for the Endothelial-specific Receptor Tyrosine Kinase Tie2* (1998) (450)
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. (2004) (450)
Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study (2016) (445)
Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. (1999) (438)
Intravitreal Aflibercept for Diabetic Macular Edema: 100-Week Results From the VISTA and VIVID Studies. (2015) (436)
Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy (2004) (433)
A Protein‐Truncating HSD17B13 Variant and Protection from Chronic Liver Disease (2018) (422)
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. (2009) (417)
Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury (1995) (416)
Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration (1997) (415)
Lhx6 Delineates a Pathway Mediating Innate Reproductive Behaviors from the Amygdala to the Hypothalamus (2005) (414)
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes. (2016) (414)
The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development (1993) (409)
Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase (1986) (409)
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters (2020) (405)
Targeting key proximal drivers of type 2 inflammation in disease (2015) (404)
The alphas, betas, and kinases of cytokine receptor complexes (1993) (401)
Vasculogenesis, Angiogenesis, and Growth Factors: Ephrins Enter the Fray at the Border (1998) (397)
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. (1993) (397)
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice (2010) (388)
Alternative forms of rat TrkC with different functional capabilities (1993) (386)
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth (1995) (385)
Regulation of the assembly and expression of variable-region genes. (1986) (385)
Regulation of Genome Rearrangement Events during Lymphocyte Differentiation (1986) (384)
Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. (2001) (381)
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. (2007) (379)
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease. (2016) (372)
Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. (2002) (372)
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. (1998) (367)
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. (2003) (366)
Cytokine traps: multi-component, high-affinity blockers of cytokine action (2003) (358)
Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. (2014) (356)
REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19 (2021) (345)
Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. (1998) (330)
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma (2002) (326)
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis (2019) (321)
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. (2003) (320)
ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A (2015) (317)
Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2. (2001) (313)
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity (2001) (310)
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. (2002) (310)
Genetic identification of familial hypercholesterolemia within a single U.S. health care system (2016) (307)
The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins (1994) (302)
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. (2006) (300)
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism (1988) (299)
Vascular Apoptosis and Involution in Gliomas Precede Neovascularization: A Novel Concept for Glioma Growth and Angiogenesis (2000) (299)
Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor (1991) (297)
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice (2010) (296)
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth (2007) (296)
Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). (2004) (295)
Mice Lacking Brain-Derived Neurotrophic Factor Exhibit Visceral Sensory Neuron Losses Distinct from Mice Lacking NT4 and Display a Severe Developmental Deficit in Control of Breathing (1996) (293)
Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice (2014) (288)
Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 (2021) (287)
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells (1997) (285)
Neurotrophic Factors and Their Receptors (1994) (266)
Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. (2001) (264)
Recombination between immunoglobulin variable region gene segments is enhanced by transcription (1986) (256)
Effect of a monoclonal antibody to PCSK9 on LDL cholesterol. (2012) (256)
Evinacumab for Homozygous Familial Hypercholesterolemia. (2020) (253)
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells (2006) (252)
The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism (2001) (252)
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity (2005) (252)
Rapsyn Is Required for MuSK Signaling and Recruits Synaptic Components to a MuSK-Containing Scaffold (1997) (250)
Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung (2009) (248)
Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial (2021) (247)
Exome sequencing and characterization of 49,960 individuals in the UK Biobank (2020) (244)
Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. (1997) (240)
Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130 (1994) (240)
F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses (2007) (240)
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade (2003) (239)
Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. (2002) (237)
Modeling the Initiation and Progression of Human Acute Leukemia in Mice (236)
In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis (1999) (235)
Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes (2014) (233)
Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development (2000) (229)
Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B (2000) (222)
Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis. (2019) (222)
Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis. (1996) (221)
Secondary genomic rearrangement events in pre‐B cells: VHDJH replacement by a LINE‐1 sequence and directed class switching. (1986) (220)
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. (2013) (219)
Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. (2002) (213)
ANGPTL3 Inhibition in Homozygous Familial Hypercholesterolemia. (2017) (213)
Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial. (2020) (212)
The angiopoietins: Yin and Yang in angiogenesis. (1999) (212)
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade (2007) (212)
C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice (2016) (211)
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung (2011) (211)
Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection (2015) (206)
Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice (1990) (205)
ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion (2014) (201)
Suppression of diabetic retinopathy with angiopoietin-1. (2002) (201)
Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130. (1992) (199)
Direct intramuscular injection of plasmid DNA encoding angiopoietin-1 but not angiopoietin-2 augments revascularization in the rabbit ischemic hindlimb. (1998) (197)
Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis (2019) (197)
Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. (2013) (192)
Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a Phase III Study (2015) (192)
Angiopoietin‐2 plays an important role in retinal angiogenesis (2002) (190)
Normal Lymphatic Development and Function in Mice Deficient for the Lymphatic Hyaluronan Receptor LYVE-1 (2006) (189)
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo (2010) (189)
The ciliary neurotrophic factor and its receptor, CNTFRα (2000) (188)
Developmentally regulated and strain-specific expression of murine VH gene families (1988) (188)
Neurotrophin Regulation of the Developing Nervous System: Analyses of Knockout Mice (1997) (188)
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering (2003) (188)
p53 induction and activation of DDR1 kinase counteract p53‐mediated apoptosis and influence p53 regulation through a positive feedback loop (2003) (187)
LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. (1993) (186)
EphB ligand, ephrinB2, suppresses the VEGF‐ and angiopoietin‐1‐induced Ras/mitogen‐activated protein kinase pathway in venous endothelial cells (2002) (185)
Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial (2013) (182)
VEGF-mediated inflammation precedes angiogenesis in adult brain (2004) (180)
Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. (1997) (176)
Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. (2008) (174)
Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice. (1999) (173)
Selective Inhibition of Kindling Development by Intraventricular Administration of TrkB Receptor Body (1999) (173)
Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization (2000) (173)
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain (2008) (170)
Exome sequencing and analysis of 454,787 UK Biobank participants (2021) (166)
Ephrins and their receptors: a repulsive topic? (1997) (166)
Neurotrophic Factor Receptors and Their Signal Transduction Capabilities in Rat Astrocytes (1994) (164)
Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. (2006) (163)
TLR8 deficiency leads to autoimmunity in mice. (2010) (163)
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis (2006) (162)
Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle (1994) (158)
Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. (2000) (156)
N-myc can cooperate with ras to transform normal cells in culture. (1985) (154)
Loss-of-Function Analysis of EphA Receptors in Retinotectal Mapping (2004) (153)
Distinct Domains of Musk Mediate Its Abilities to Induce and to Associate with Postsynaptic Specializations (1999) (152)
Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. (2006) (150)
Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells. (2002) (150)
Degeneration of vestibular neurons in late embryogenesis of both heterozygous and homozygous BDNF null mutant mice. (1996) (148)
Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina. (1996) (147)
ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys1[S] (2015) (146)
Laminin-induced Acetylcholine Receptor Clustering: An Alternative Pathway (1997) (145)
K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses. (1992) (145)
Efficient differentiation and function of human macrophages in humanized CSF-1 mice. (2011) (143)
Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression. (1999) (142)
The neurotrophins and their receptors. (1993) (141)
Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family. (1993) (141)
The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing. (2011) (141)
Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis (2007) (137)
Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells (2016) (137)
Agouti-related protein-deficient mice display an age-related lean phenotype. (2005) (135)
Vascular Endothelial Growth Factor Trap Combined with Paclitaxel Strikingly Inhibits Tumor and Ascites, Prolonging Survival in a Human Ovarian Cancer Model (2005) (135)
Efficacy and safety of dupilumab with concomitant topical corticosteroids in children 6 to 11 years old with severe atopic dermatitis: a randomized, double-blinded, placebo-controlled phase 3 trial. (2020) (135)
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis (2009) (134)
The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression (1997) (133)
ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance[S] (2017) (133)
Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation (2019) (133)
Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor (2011) (132)
Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN) (2014) (132)
Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. (1998) (131)
Discoidin Domain Receptor 2 Interacts with Src and Shc following Its Activation by Type I Collagen* (2002) (131)
EphA2 Promotes Infiltrative Invasion of Glioma Stem Cells in vivo through Crosstalk with Akt and Regulates Stem Properties (2014) (130)
Protection Against Myocardial Infarction and No-Reflow Through Preservation of Vascular Integrity by Angiopoietin-Like 4 (2012) (129)
The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies (2021) (128)
Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement (2018) (128)
Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response (2018) (127)
Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK Biobank (2019) (126)
Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice. (2017) (124)
Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. (1996) (124)
VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. (2007) (123)
Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis1 (2006) (122)
Mice completely lacking immunoproteasomes display major alterations in antigen presentation (2011) (116)
Vascular Endothelial Growth Factor Trap Blocks Tumor Growth, Metastasis Formation, and Vascular Leakage in an Orthotopic Murine Renal Cell Cancer Model (2007) (116)
Angiopoietin‐1 activates both anti‐ and proapoptotic mitogen‐activated protein kinases (2003) (115)
Agrin and microvascular damage in Alzheimer's disease (2000) (115)
Activin A more prominently regulates muscle mass in primates than does GDF8 (2017) (115)
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. (2009) (114)
Molecular Events Implicated in Brain Tumor Angiogenesis and Invasion (2000) (113)
Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period (2005) (113)
Humanized mouse model supports development, function, and tissue residency of human natural killer cells (2017) (111)
Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice. (2006) (111)
Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype (2018) (110)
Structure and expression of the murine N-myc gene. (1986) (110)
The human myc gene family. (1986) (110)
The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow. (2011) (109)
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice (2015) (107)
Identification of functional receptors for ciliary neurotrophic factor on neuronal cell lines and primary neurons (1990) (107)
Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood–retinal barrier (2004) (106)
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis (2003) (105)
Regulation of bone marrow stromal cell differentiation by cytokines whose receptors share the gp130 Protein (1994) (104)
Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial. (2012) (104)
Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice (2003) (104)
Patients With High Genome-Wide Polygenic Risk Scores for Coronary Artery Disease May Receive Greater Clinical Benefit From Alirocumab Treatment in the ODYSSEY OUTCOMES Trial (2019) (103)
Infections in Dupilumab Clinical Trials in Atopic Dermatitis: A Comprehensive Pooled Analysis (2019) (103)
A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys (2015) (103)
Interleukin‐19 protects mice from innate‐mediated colonic inflammation (2010) (103)
The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. (1987) (102)
The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis (2008) (99)
Hepatocyte Growth Factor Promotes Motor Neuron Survival and Synergizes with Ciliary Neurotrophic Factor* (1997) (99)
Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn. (1999) (98)
Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes. (1992) (97)
Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. (1998) (97)
Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein α Subunit Membrane Association (2011) (96)
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial. (2021) (96)
CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neurons (1994) (95)
Long form of latent TGF-β binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling (2007) (95)
Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: required role for the MuSK ectodomain? (1997) (93)
Interleukin-22 promotes fibroblast- mediated wound repair in the skin (2012) (93)
Rilonacept (interleukin‐1 trap) for prevention of gout flares during initiation of uric acid–lowering therapy: Results from a phase III randomized, double‐blind, placebo‐controlled, confirmatory efficacy study (2012) (93)
Goblet Cell-Derived Resistin-Like Molecule β Augments CD4+ T Cell Production of IFN-γ and Infection-Induced Intestinal Inflammation1 (2008) (92)
The ciliary neurotrophic factor and its receptor, CNTFR alpha. (2000) (92)
Different effects of angiopoietin‐2 in different vascular beds in the eye: new vessels are most sensitive (2005) (91)
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes (2018) (91)
Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. (1999) (90)
Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody (2015) (89)
The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases (1998) (87)
Localization and regulation of MuSK at the neuromuscular junction. (1998) (86)
Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression. (1993) (86)
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity (2021) (85)
Neurotrophin 4 Is Required for the Survival of a Subclass of Hair Follicle Receptors (1998) (85)
Odronextamab (REGN1979), a Human CD20 x CD3 Bispecific Antibody, Induces Durable, Complete Responses in Patients with Highly Refractory B-Cell Non-Hodgkin Lymphoma, Including Patients Refractory to CAR T Therapy (2020) (83)
Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. (2009) (82)
VEGF-dependent conjunctivalization of the corneal surface. (2003) (82)
Genetic Deletion of Trb3, the Mammalian Drosophila tribbles Homolog, Displays Normal Hepatic Insulin Signaling and Glucose Homeostasis (2007) (82)
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. (2004) (82)
Peptide YY regulates bone turnover in rodents. (2007) (82)
A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap. (2010) (81)
Mistargeting hippocampal axons by expression of a truncated Eph receptor (2002) (80)
Methods for cloning and analysis of eukaryotic genes (1990) (80)
Survival with Cemiplimab in Recurrent Cervical Cancer. (2022) (80)
A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production. (2017) (78)
Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells. (2001) (77)
Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration. (2011) (77)
The molecular biology of the CNTF receptor (1993) (76)
Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. (2009) (76)
Insulin-like Growth Factor-1 ( IGF-1 ) Inversely Regulates Atrophy-induced Genes via the Phosphatidylinositol 3-Kinase / Akt / Mammalian Target of Rapamycin ( PI 3 K / Akt / mTOR ) Pathway * (2005) (75)
Efficacy and Safety of Itepekimab in Patients with Moderate-to-Severe Asthma. (2021) (74)
Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance (2020) (74)
Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, phase 3, randomized, placebo-controlled trial. (2013) (73)
Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome (2001) (73)
Development of the neuromuscular junction: Genetic analysis in mice (1998) (73)
Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys. (2015) (72)
Alteration of Developmental and Pathological Retinal Angiogenesis in angptl4-deficient Mice* (2011) (72)
Angiopoietin-2 is a site-specific factor in differentiation of mouse renal vasculature. (2000) (71)
Antidrug Antibodies in Patients Treated with Alirocumab. (2017) (71)
Sequential roles of agrin, MuSK and rapsyn during neuromuscular junction formation (1997) (71)
Agrin and microvascular damage in Alzheimer’s disease (2000) (71)
Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis (2019) (71)
A Sweat Gland-derived Differentiation Activity Acts through Known Cytokine Signaling Pathways* (1997) (67)
Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke. (2013) (67)
Sustained VEGF Blockade Results in Microenvironmental Sequestration of VEGF by Tumors and Persistent VEGF Receptor-2 Activation (2008) (67)
Leucine Aminopeptidase Is Not Essential for Trimming Peptides in the Cytosol or Generating Epitopes for MHC Class I Antigen Presentation1 (2005) (66)
Impact of vessel maturation on antiangiogenic therapy in ovarian cancer. (2008) (64)
Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. (2010) (64)
Peripheral Myelin Protein 22 Is in Complex with α6β4 Integrin, and Its Absence Alters the Schwann Cell Basal Lamina (2006) (63)
Cloning and Characterization of Muscle-Specific Kinase in Chicken (2000) (62)
Structure and expression of the murine L‐myc gene. (1987) (62)
Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation. (2008) (61)
Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury. (2008) (60)
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281. (2012) (59)
Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs (2015) (58)
Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1 (2010) (58)
Agrin in Alzheimer's Disease: Altered Solubility and Abnormal Distribution within Microvasculature and Brain Parenchyma (1999) (58)
Abnormal recruitment of periendothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice (2007) (57)
Expression and functionality of the trkA proto-oncogene product/NGF receptor in undifferentiated hematopoietic cells (1994) (56)
Conditionals by inversion provide a universal method for the generation of conditional alleles (2013) (56)
Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature. (2004) (55)
Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial. (2022) (55)
The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Double‐Blind, Placebo‐Controlled, Randomized Clinical Trial (2019) (55)
Glucagon contributes to liver zonation (2018) (54)
Puromycin-Sensitive Aminopeptidase Limits MHC Class I Presentation in Dendritic Cells but Does Not Affect CD8 T Cell Responses during Viral Infections1 (2008) (54)
Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab (2012) (54)
ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice (2017) (53)
Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis. (1994) (53)
Clinical Activity of REGN1979, a Bispecific Human, Anti-CD20 x Anti-CD3 Antibody, in Patients with Relapsed/Refractory (R/R) B-Cell Non-Hodgkin Lymphoma (B-NHL) (2019) (52)
VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene- based discovery of the next generation of angiogenesis targets. (2005) (52)
Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice. (2004) (51)
Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants (2020) (50)
IL-33 blockade impacts mediators of persistence and exacerbation in a model of chronic airway inflammation. (2019) (50)
Myc family of cellular oncogenes (1987) (50)
Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade. (2016) (49)
Complementary and coordinated roles of the VEGFs and angiopoietins during normal and pathologic vascular formation. (2002) (49)
Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice (2017) (49)
Dll4–Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice (2012) (48)
A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies (2020) (48)
Axon guidance in the mouse optic chiasm: retinal neurite inhibition by ephrin "A"-expressing hypothalamic cells in vitro. (2000) (47)
Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung (2009) (46)
REGN5458, a BCMA x CD3 Bispecific Monoclonal Antibody, Induces Deep and Durable Responses in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) (2020) (46)
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering (2003) (46)
Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy (2021) (45)
Clinical Application of Therapies Targeting VEGF (2010) (45)
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation and is a functional receptor for agrin. (1996) (45)
Angiomodulin Is a Specific Marker of Vasculature and Regulates Vascular Endothelial Growth Factor-A–Dependent Neoangiogenesis (2009) (45)
Sexual Dimorphism in the Spinal Cord Is Absent in Mice Lacking the Ciliary Neurotrophic Factor Receptor (1997) (45)
Modulation of the angiogenesis response through Ha‐ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis (2003) (44)
Naturally Occurring Tyrosine Kinase Inserts Block High Affinity Binding of Phospholipase Cγ and Shc to TrkC and Neurotrophin-3 Signaling (*) (1995) (42)
Expression and functionality of the trkA proto-oncogene product/NGF receptor in undifferentiated hematopoietic cells. (1994) (42)
Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma. (2021) (41)
Agrin Receptors at the Skeletal Neuromuscular Junction (1998) (40)
Motoneuron Survival Is Enhanced in the Absence of Neuromuscular Junction Formation in Embryos (2001) (40)
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity (2018) (40)
Differential activation of the extracellular signal‐regulated kinase, Jun Kinase and Janus Kinase‐Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS‐derived Kaposi's sarcoma cells (1996) (39)
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. (2005) (39)
GDNF in a Bind with Known Orphan: Accessory Implicated in New Twist (1996) (39)
Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination (2010) (39)
Functional Characterization of Mouse RDH11 as a Retinol Dehydrogenase Involved in Dark Adaptation in Vivo* (2005) (38)
Designer Cytokines: Targeting Actions to Cells of Choice (1995) (38)
Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma. (1999) (38)
Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy (2020) (38)
Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics (2020) (37)
REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters (2020) (37)
Neurotrophic factor receptors: just like other growth factor and cytokine receptors? (1994) (36)
Effects of gene delivery on collateral development in chronic hypoperfusion: diverse effects of angiopoietin-1 versus vascular endothelial growth factor. (2004) (36)
Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis (2009) (36)
Immunoglobulin genes in transgenic mice (1985) (36)
Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina. (2006) (34)
Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses (2007) (34)
Rapid decrease in tumor perfusion following VEGF blockade predicts long-term tumor growth inhibition in preclinical tumor models (2012) (33)
Expression of trk in MAH cells lacking the p75 low-affinity nerve growth factor receptor is sufficient to permit nerve growth factor-induced differentiation to postmitotic neurons. (1994) (33)
Safety and Preliminary Clinical Activity of REGN5458, an Anti-Bcma x Anti-CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma (2019) (33)
Transcriptional down-regulation of N-myc expression during B-cell development (1992) (33)
Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor (2018) (32)
Inactivating Variants in ANGPTL 4 and Risk of Coronary Artery Disease (2016) (31)
ANGPTL4–αvβ3 interaction counteracts hypoxia‐induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2 (2016) (31)
Expression of the immunoglobulin heavy-chain variable gene repertoire. (1987) (31)
Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection. (2011) (30)
The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome (2008) (29)
Angiopoietin-1 and pulmonary hypertension: cause or cure? (2003) (29)
Dexamethasone Treatment and ICAM-1 Deficiency Impair VEGF-Induced Angiogenesis in Adult Brain (2007) (28)
Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes (2016) (28)
Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial. (2021) (28)
Glucagon orchestrates stress‐induced hyperglycaemia (2016) (28)
Gene sequences of chicken BDNF and NT-3. (1992) (27)
Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion. (2018) (27)
TNP-470 promotes initial vascular sprouting in xenograft tumors. (2004) (27)
Producing fully ES cell-derived mice from eight-cell stage embryo injections. (2010) (27)
Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents (2006) (26)
Single-Cell RNAseq Reveals That Pancreatic β-Cells From Very Old Male Mice Have a Young Gene Signature. (2016) (26)
Molecular taxonomy of human ocular outflow tissues defined by single cell transcriptomics (2020) (25)
VelociMouse: fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos. (2009) (24)
Ongoing Dll4‐Notch signaling is required for T‐cell homeostasis in the adult thymus (2011) (23)
Association of High Serum Interleukin‐6 Levels With Severe Progression of Rheumatoid Arthritis and Increased Treatment Response Differentiating Sarilumab From Adalimumab or Methotrexate in a Post Hoc Analysis (2020) (23)
Isolation of coordinately regulated genes that are expressed in discrete stages of B-cell development. (1990) (23)
Dll 4 blockade inhibits tumor growth by promoting non-productive angiogenesis (2006) (22)
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie 2 ( cancer y adenovirus y soluble receptor y tumor angiogenesis ) (1998) (22)
Cemiplimab plus chemotherapy versus chemotherapy alone in non-small cell lung cancer: a randomized, controlled, double-blind phase 3 trial (2022) (21)
Passive Prophylactic Administration with a Single Dose of Anti–Fel d 1 Monoclonal Antibodies REGN1908–1909 in Cat Allergen–induced Allergic Rhinitis: A Randomized, Double-Blind, Placebo-controlled Clinical Trial (2021) (21)
Intravitreal A fl ibercept for Diabetic Macular Edema (2014) (20)
Receptors and signaling pathways of ciliary neurotrophic factor and the neurotrophins (1993) (20)
The loss-of-allele assay for ES cell screening and mouse genotyping. (2010) (20)
The anti-inflammatory actions of angiopoietin-1. (2005) (20)
A first‐in‐human pharmacodynamic and pharmacokinetic study of a fully human anti‐glucagon receptor monoclonal antibody in normal healthy volunteers (2017) (20)
A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity. (1990) (19)
Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. (1988) (19)
Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a Phase 1 study. (2021) (19)
Angptl4 does not control hyperglucagonemia or α-cell hyperplasia following glucagon receptor inhibition (2017) (19)
Poueymirou, W.T. et al. F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nat. Biotechnol. 25, 91-99 (2007) (19)
GPR17 gene disruption does not alter food intake or glucose homeostasis in mice (2015) (18)
Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice. (2015) (16)
Developmental biology: Gridlock in the blood (2001) (16)
Casirivimab and Imdevimab for the Treatment of Hospitalized Patients With COVID-19 (2021) (15)
The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells (2019) (14)
Germline Mutations in CIDEB and Protection against Liver Disease. (2022) (14)
A Randomized Placebo-Controlled Trial of Sarilumab in Hospitalized Patients with Covid-19 (2021) (13)
Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine (2020) (13)
Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised clinical trial (2020) (13)
Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration. (2018) (12)
Assignment1 of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping (1999) (12)
Gene Signature of Proliferating Human Pancreatic &agr; Cells (2018) (12)
Expression Cloning and Characterization of NSIST, a Novel Sulfotransferase Expressed by a Subset of Neurons and Postsynaptic Targets (1998) (12)
Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial (2022) (12)
Identification and characterisation of chicken cDNAs encoding the endothelial cell-specific receptor tyrosine kinase Tie2 and its ligands, the angiopoietins (2004) (11)
Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response. (2021) (11)
Control of Recombination Events During Lymphocyte Differentiation: Heavy Chain Variable Region Gene Assembly and Heavy Chain Class Switching a (1988) (11)
Reconstruction of an immune system. (1988) (10)
Cooperative Roles for the Angiopoietins and Vascular Endothelial Growth Factor in Ovarian Angiogenesis (2000) (10)
Reduction of LDL cholesterol by a monoclonal antibody to PCSK9 in rodents and nonhuman primates (2012) (9)
The long non-coding RNAs : a new ( p ) layer in the “ dark matter ” (2014) (9)
DNA recombination in the brain? (1991) (8)
428 Interim analysis of Phase 2 results for cemiplimab in patients with metastatic basal cell carcinoma (mBCC) who progressed on or are intolerant to hedgehog inhibitors (HHIs) (2020) (8)
173 Interleukin-22 Provides Protection to Tissues during Inflammation (2007) (8)
REGEN-COV protects against viral escape in preclinical and human studies (2021) (8)
DEGENERATION OF VESTIBULAR NEURONS IN LATE EMBRYOGENESIS OF BOTH HETEROZYGOUS BDNF NULL MUTANT MICE (1996) (8)
Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy. (2020) (7)
The molecular biology of the CNTF receptor. (1993) (7)
Compassionate Use of REGEN-COV® in Patients With Coronavirus Disease 2019 (COVID-19) and Immunodeficiency-Associated Antibody Disorders (2021) (7)
Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis. (2022) (7)
Growth Factors in Vascular Morphogenesis: Insights from Gene Knockout Studies in Mice (1996) (7)
Structural determinants of Trk receptor specificities using BNDF‐based neurotrophin chimeras (1996) (7)
Low Dose, Subconjunctival Administration of VEGF Trap Inhibits Suture–Induced Corneal Neovascularization and Inflammation (2006) (6)
Systemic Administration of VEGF Trap Suppresses Vascular Leak and Leukostasis in the Retinas of Diabetic Rats (2005) (6)
Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus (2021) (6)
Regulation of immunoglobulin variable-region gene assembly. (1986) (6)
Profiling copy number variation and disease associations from 50,726 DiscovEHR Study exomes (2017) (6)
VEGF Trap Both Prevents Experimental Choroidal Neovascularization and Causes Regression of Established Lesions in Non–Human Primates (2005) (6)
Circular T-cell receptor gene recombination products (1987) (5)
Intravitreal Administration of VEGF Trap Suppresses Vascular Leak in the Retinas of Diabetic Rats (2006) (5)
Disruption of nuclear envelope integrity as a possible initiating event in tauopathies. (2022) (5)
Corrigendum: VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis (2009) (5)
The effect of the scid mutation on mechanism and control of immunoglobulin heavy and light chain gene rearrangement. (1989) (5)
Myc family genes: a dispersed multi-gene family. (1986) (5)
SAR440340, An Anti-IL-33 Monoclonal Antibody, Demonstrated a Significant Reduction of LOAC Events and Improved Pre-BD FEV1 in Patients with Moderate to Severe Asthma: Results from the Phase 2 Proof of Concept Study (2020) (5)
Repeat Subcutaneous Administration of REGEN-COV(R) in Adults is Well-Tolerated and Prevents the Occurrence of COVID-19 (2021) (5)
Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature (2017) (5)
Efficacy and Safety of Sarilumab in Hospitalized Patients With Coronavirus Disease 2019: A Randomized Clinical Trial (2022) (4)
CLINICAL ACTIVITY OF REGN1979, AN ANTI‐CD20 X ANTI‐CD3 BISPECIFIC ANTIBODY (AB) IN PATIENTS (PTS) WITH (W/) RELAPSED/REFRACTORY (R/R) B‐CELL NON‐HODGKIN LYMPHOMA (B‐NHL) (2019) (4)
Exome sequencing and characterization of 49,960 individuals in the UK Biobank (2020) (4)
Genetic modulation of pigment epithelium–derived factor (PEDF) expression does not alter normal or pathological angiogenesis in the eye, or tumor growth. (2004) (4)
Baseline Biomarkers of T-Cell Function Correlate with Clinical Responses to Odronextamab (REGN1979), and Loss of CD20 Target Antigen Expression Identified As a Mechanism of Treatment Resistance (2020) (4)
Repeat subcutaneous administration of casirivimab and imdevimab in adults is well-tolerated and prevents the occurrence of COVID-19 (2022) (4)
Reply: Calcineurin and skeletal muscle growth (2002) (4)
Generation of fertile and fecund F0 XY female mice from XY ES cells (2015) (4)
The Ties That Bind: Emerging Concepts About the Structure and Function of Angiopoietins and Their Receptors in Angiogenesis (2002) (4)
Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes (2022) (4)
Non-animal-derived antibodies: pharma companies respond (2020) (3)
Virologic Efficacy of Casirivimab and Imdevimab COVID-19 Antibody Combination in Outpatients With SARS-CoV-2 Infection (2022) (3)
Eye Phenotype of Pigment Epithelium-Derived Factor Knockout Mice (2003) (3)
Making antigen-receptor genes (1989) (3)
Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trial (2022) (3)
Subcutaneous REGEN-COV Antibody Combination in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial (2021) (3)
Humanization of T cell–mediated immunity in mice (2021) (3)
Efficacy and safety of a single dose of casirivimab and imdevimab for the prevention of COVID-19 over an 8-month period: a randomised, double-blind, placebo-controlled trial (2022) (3)
REGN1908/1909 prevented cat allergen-induced early asthmatic responses in an environmental exposure unit. (2022) (3)
Association of complement pathways with COVID-19 severity and outcomes (2022) (3)
Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection. (2011) (3)
Intravitreal Administration of VEGF Trap Inhibits Pathological Retinal Neovascularization in a Mouse Model of Oxygen Induced Retinopathy (2006) (2)
LB4. Casirivimab and Imdevimab for Treatment of Hospitalized Patients With COVID-19 Receiving Low Flow or No Supplemental Oxygen (2021) (2)
Co-administration of an Antibody to Angiopoietin2 Extends the Duration of the Anti-Vascular Leak Activity of Aflibercept in a Model of Sustained Retinal Neovascularization (RNV) (2017) (2)
Improvement of Fractionated Radiation Therapy by Combination with VEGF Blocker, VEGF Trap (2005) (2)
Abstract 16563: Genetic and Pharmacological Inactivation of ANGPTL3 is Associated With Reduced Atherosclerotic Cardiovascular Disease (2016) (2)
Abstract 4492: Blockade of angiopoietin-2 or Tie2 is equally effective at inhibiting tumor growth and reducing tumor vessel density in most human tumor xenograft models (2014) (2)
Long-lasting Inhibition of Corneal Neovascularization following Systemic Administration of the VEGF Trap (2003) (2)
Evaluation of complement activity in wild type, C5 knockout and humanized mice for drug discovery (2014) (2)
Clinical Development of VEGF Trap (2008) (2)
Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties (2019) (2)
Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis (2008) (2)
Inhibiting Platelet Derived Growth Factor Receptor β (PDGFRβ) reduces pericytes coverage and effects vessel morphology and growth in developing retinal vessels in pups but not mature vessels in adult mice (2014) (2)
Regulation of the Assembly and Expression of Immunoglobulin Genes: Variable Region Assembly and Heavy Chain Class Switching (1986) (1)
Pozelimab, a Human Monoclonal Antibody Against Complement Factor C5, Provided Inhibition of Intravascular Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria (2021) (1)
ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma (2022) (1)
Subconjunctival Administration of VEGF Trap Suppresses Corneal Neovascularization (2004) (1)
Histologic Evaluation of Laser–Induced Choroidal Neovascularization (CNV) in Primates Receiving Intravitreal Injections of VEGF Trap: Correlation With Fluorescein Angiography (2006) (1)
The Expression of Angiogenic Factors and Their Receptors During Retinal Neovascularization: Effects of VEGF Trap Administration (2003) (1)
Inhibition of IL-1 Blocks Corneal Inflammation and Neovascularization (2003) (1)
Genetic deletion of TLR4 increases retinal ganglion cell survival after optic nerve injury (2013) (1)
Structural insights into the assembly of gp130 family cytokine signaling complexes (2022) (1)
Generating Epitopes for MHC Class I Trimming Peptides in the Cytosol or Leucine Aminopeptidase Is Not Essential for Yancopoulos (2005) (1)
Resistin Like Molecule Beta Regulates Intestinal Inflammation in Chronic Colitis (2007) (1)
Neurotrophin-3, a new neurotrophic factor related to the nerve growth factor and brain-derived neurotrophic factor from (1990) (1)
IL6, IL11, LIF, OSM, cardiotrophin-1, and CNTF: An example of a cytokine family sharing signal transducing receptor components (1997) (1)
Atopic dermatitis and skin disease Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis (1)
Delta-like ligand 4 (Dll4) is critical for tumor growth and angiogenesis. (2006) (1)
Angiopoietin-like protein 3 (ANGPTL3) governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance (2020) (1)
Deletion of a Single Dll4 Allele Alters Retinal Vascular Development in Mice (2006) (1)
Developmental expression and upregulation of muscle-specific kinase (MuSK) in denervated skeletal muscle of the chick and rat (1996) (1)
B Cell Differentiation: Development of Antibody Repertoires (1989) (1)
A Single-Dose of REGN1908-1909 Reduced Bronchoconstriction in Cat-Allergic Subjects with Mild Asthma for up to 3 months following a controlled cat allergen challenge: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study (2021) (1)
Neurotrophin-4 or Neurotrophin-5? (1992) (1)
IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline. (2022) (1)
Casirivimab and Imdevimab Treatment Reduces Viral Load and Improves Clinical Outcomes in Seropositive Hospitalized COVID-19 Patients with Nonneutralizing or Borderline Neutralizing Antibodies (2022) (1)
Experimental Colitis Production in T Cell-Dependent Cutting Edge : IL-23 Cross-Regulates IL-12 (2006) (1)
Inhibition of Corneal Angiogenesis by Topical Administration of VEGF Trap (2007) (1)
Effects of Inhibition of PDGF Family Ligands and Receptors on Pericytes and Blood Vessel Morphology in the Developing Mouse Retina (2017) (1)
Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM (2022) (1)
ANGIOPOIETIN-1 EXPRESSION IN SPORADIC AND VONHIPPEL-LINDAU DISEASE-ASSOCIATED HEMANGIOBLASTOMAS (1998) (1)
COVID-19 prevention with subcutaneous administration of the monoclonal antibodies casirivimab and imdevimab: Subgroup analysis in participants with cardiovascular disease and diabetes (2021) (1)
CLINICAL RESPONSES TO ODRONEXTAMAB (REGN1979): CORRELATION WITH LOSS OF CD20 EXPRESSION AS A POTENTIAL MECHANISM OF RESISTANCE AND BASELINE BIOMARKERS OF TUMOR T CELLS (2021) (1)
Kappa-on-Heavy (KoH)bodies: A potential new class of fully-human antibody-like therapeutic agents with novel antigen-binding properties (2019) (1)
Placental Growth Factor (PlGF) Deficient Mice Show Delays in Normal Retinal Vascular Development and Reduced Vascular Abnormalities in Oxygen-Induced Retinal Ischemia (2009) (1)
Genetic and Functional Characterization of ANGPTL7 as a Therapeutic Target for Glaucoma (2021) (0)
Methods of lowering blood glucose levels (2017) (0)
Effects of VEGF Trap and Bevacizumab on Neovascularization and Retinal Revascularization in Murine Model of Oxygen Induced Retinopathy (OIR) (2012) (0)
VelociGene and VelociMouse: High-Throughput Approaches for Generating Targeted Mutations in Mice on a Genome-Wide Scale (2009) (0)
Receptors and Signaling Pathways Used by the Neurotrophins, CNTF and a New Family of Neurotrophic Factors, the EFLs (1995) (0)
Effects of Anti-PDGFRβ Therapy Alone or in Combination with VEGF Trap on Corneal Neovascularization (NV) and Pericyte Recruitment in Mice (2014) (0)
Pathological retinal neovascularization is exacerbated by selective pharmacological blockade of VEGFR2, but ameliorated by combination with Placental Growth Factor (PlGF) inhibition in the Oxygen induced Retinopathy (OIR) model in mice (2013) (0)
Survival With Cemiplimab in Recurrent Cervical Cancer (2022) (0)
Rapid decrease in tumor perfusion following VEGF blockade predicts long-term tumor growth inhibition in preclinical tumor models (2012) (0)
Evaluation of anti-human complement component 5 antibody in humanized C5 mice (2017) (0)
Genetic Deletion of Notch-Regulated Ankryrin- Repeat Protein (NRARP) Affects Normal Retinal Vascular Development and Neovascularization in the OIR Model in Mice (2008) (0)
Neutralization of Angiopoietin-2 Inhibits Progression and Promotes Regression of Choroidal Neovascularization (2008) (0)
IL-1 receptor fusion proteins used as antagoniste and methods for their use and manufacture (1999) (0)
And grafting genetically modified mice (2010) (0)
Modified chimeric polypeptides with improved properties pharmakokynetischen (2000) (0)
Generation of fertile and fecund F0 XY female mice from XY ES cells (2014) (0)
Fusion polypeptides IGF-1 and therapeutic uses thereof (2006) (0)
Methode de regression tumorale avec des inhibiteurs vegf (2004) (0)
Low Dose or Transient Administration of VEGF Trap Suppresses Corneal Neovascularization and Inflammation (2005) (0)
Blocking common γ chain cytokine signaling ameliorates T cell–mediated pathogenesis in disease models (2023) (0)
Muscle-specific kinase (MuSK) mediates nerve-induced tyrosine phosphorylation and aggregation of acetylcholine receptors in neuron-muscle co-cultures. (1996) (0)
Abstract CT165: Primary analysis of phase 2 results for cemiplimab in patients with metastatic basal cell carcinoma who progressed on or were intolerant to hedgehog inhibitors (2022) (0)
STAT 3 activation by cytokines utilizing gp 130 and related transducers involves a secondary modification reqluiring an H 7-sensitive kinase ( ciliary neurotrophic factor / interleukin 6 / leukemia-inhibitory factor / oncostatin M / granulocyte colony-stimulating factor ) (2005) (0)
Isolation ofscidpre-B cells thatrearrangekappalight chain genes:formation ofnormalsignal andabnormal codingjoins (1989) (0)
Biologically active ligands of the eph family (1995) (0)
Efficacy of an IL-6R antibody in a novel murine dry eye model (2015) (0)
Velocigene a high throughput process for identifying and analyzing neuronal genes by expression and loss of function (2002) (0)
Fusion proteins receptor il-1 antagonists and methods used to obtain them and use them. (1999) (0)
Procedure of modifying eukaryotic cells (2002) (0)
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials. (2023) (0)
IFG-1fusionspolypeptider and therapeutic uses thereof (2006) (0)
Improvement of glioblastoma control by combining the VEGF blocker, VEGF trap with fractionated radiotherapy: impact of scheduling (2006) (0)
McDonald and colleagues reply (1993) (0)
Comparison of transcriptional differences between IL-4Ra and IL-5 blockade in a mouse model of asthma (2021) (0)
VEGF Trap Promotes Regression of Choroidal Neovascularization (CNV) and Inhibits Fibrosis and Inflammation in the Subretinal Matrigel CNV Model (2009) (0)
Systemic Administration of VEGF Trap Prevents Pervasive Blood Vessel Regression in the Murine Model of Oxygen-Induced Retinopathy (OIR) (2012) (0)
Method of treating an allergy with allergen-specific monoclonal antibodies (2017) (0)
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes (2018) (0)
Casirivimab and Imdevimab Treatment in Seropositive, Hospitalized COVID-19 Patients With Non-neutralizing or Borderline Neutralizing Antibodies (2022) (0)
Ang1 Can Maintain Structural Integrity and Impose a Higher Order Architecture on Vascular Networks in the Complete Absence of Mural Cells (2002) (0)
Eph family ligands biologically active. (1995) (0)
A method of preparing an antibody comprising a human variable region and a constant region of the rodent (2002) (0)
Expression of muscle-specific kinase at the neuromuscular junction (1996) (0)
Combined anti-PlGF and anti-VEGF Therapy Ameliorates Pathological Neovascularization and Improves Retinal Revascularization in the Murine Model of Oxygen Induced Ischemic Retinopathy (OIR) (2011) (0)
Tie-2 ligand receptor (ligand tie-4) and its use. (1997) (0)
S1701 A Crucial Role of Rorgamma Expressing TH17 Cells in Chronic Intestinal Inflammation (2008) (0)
Genetic Deletion or Pharmacological Inhibition of Angiopoietin-2 Reduces Injury-Induced Corneal Neovascularization, Lymphangiogenesis and Inflammation (2007) (0)
Neutralization of Angiopoietin-2 Inhibits Ocular Angiogenesis and Vascular Leak, and Promotes Regression of Choroidal Neovascularization (2011) (0)
CLINICAL — ALIMENTARY TRACT Ef ﬁ cacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis (0)
Angiopoietin-1 enhances inflammation and fibrosis in the chronic phase of murine folic-acid induced nephropathy (2007) (0)
A method for producing a protein, which has a brain-derived neurotrophic factor (BDNF) activity (1991) (0)
ephrin-B2+ endothelial cells Stromal cells expressing ephrin-B2 promote the growth and sprouting of (2013) (0)
Vascular Endothelial Growth Factor Trap Combinedwith Paclitaxel Strikingly Inhibits Tumor and Ascites , Prolonging Survival in a Human Ovarian (2005) (0)
Genetic Deletion of Pigment Epithelium–Derived Factor (PEDF) Does Not Alter the Development, or Subsequent Regression, of Pathological Neovascularization in a Mouse Model of Oxygen–Induced Retinopathy (2005) (0)
Broader Impact of IL-4Ra Blockade Than IL-5 Blockade on Type 2 Inflammation (2019) (0)
IL-1 receptor-based antagonists, and methods of making and use thereof (2003) (0)
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice (2015) (0)
Pharmacological Inhibition of Dll4 Ameliorates Pathological Retinal Neovascularization and Improves Retinal Revascularization in the OIR Model (2007) (0)
Isolation ofcoordinately regulated genesthatareexpressed in discrete stages ofB-cell development (1990) (0)
Abstracts from the ASENT 2007 Annual Meeting March 5–8, 2007 (2007) (0)
Dll4/Notch Inhibition Prevents Retinal Capillary Regression (2008) (0)
Nucleic acid sequence encoding a neurotrophin-3 (NT-3) protein and its use (1991) (0)
Systemic administration of an anti-IL-6R antibody mitigated visual decline in a murine model of Experimental Autoimmune Uveitis (EAU) (2017) (0)
S868 EMERGING CLINICAL ACTIVITY OF REGN1979, AN ANTI-CD20 X ANTI-CD3 BISPECIFIC ANTIBODY (AB), IN PATIENTS (PTS) WITH RELAPSED/REFRACTORY (R/R) B-CELL NON-HODGKIN LYMPHOMA (B-NHL) (2019) (0)
Erratum: Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity (2005) (0)
1198-P: Prevention of COVID-with Subcutaneous Administration of CAS+IMD in Individuals with Diabetes and Other Risk Factors for Severe Disease (2022) (0)
Production method of an antibody comprising a human variable region and a constant region of a rodent (2002) (0)
Angiopoietin-1 and Pulmonary Hypertension (2003) (0)
Poster Abstract #6: Age-Related Motor Impairment in Mice Lacking Vg1037, an Orphan GPCR Localized to Brain Motor Systems (2007) (0)
Antagonist-based receivers and methods for making and using them. (1999) (0)
CS-21EphA2 PROMOTES INFILTRATIVE INVASION OF GLIOMA STEM CELLS IN VIVO THROUGH CROSSTALK WITH Akt AND REGULATES STEM PROPERTIES (2014) (0)
Agrin induces phosphorylation of muscle-specific kinase (MuSK) in myotube culture (1996) (0)
Constitutive Somatostatin Receptor Activity Determines Tonic Pituitary Cell Response (2009) (0)
Immunology: making antigen-receptor genes. (1989) (0)
during Viral Infections but Does Not Affect CD8 T Cell Responses MHC Class I Presentation in Dendritic Cells Puromycin-Sensitive Aminopeptidase Limits (2008) (0)
The TIE-2 ligands, and methods of making and using (1997) (0)
A process for producing an antibody comprising a human variable region and a constant region of rodent (2002) (0)
Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor (2018) (0)
Placental Growth Factor (PlGF) Inhibition Decreases Neovascularization and Accelerates Retinal Revascularization in the Murine Model of Oxygen Induced Ischemic Retinopathy (2010) (0)
Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes (2016) (0)
VEGF Trap Treatment Regresses Pathological Neovessels, Improves Revascularization and Reduces Retinal Ischemia in the Murine Oxygen-Induced Retinopathy (OIR) Model (2011) (0)
17 Modulating Skeletal Muscle Hypertrophy and Atrophy: Signaling Pathways and Therapeutic Targets (2004) (0)
Role of the Leucine-rich Repeat (LRR) Domain of Cryopyrin/ NALP3 in Monosodium Urate Crystal-induced Inflammation (2011) (0)
Regulation of muscle-specific kinase (MuSK) during development and after nerve injury (1996) (0)
Lymphoid VDJ Recombinase Activity: Development of a Novel Fluorescence-Based Assay System (1989) (0)
ENDOTHELIAL CELL APOPTOSIS AND VASCULAR REGRESSION IN GLIOMAS PRECEDE NEOVASCULARIZATION: A NEW CONCEPT FOR GLIOMA GROWTH AND ANGIOGENESIS (1999) (0)
Rodent, which is capable of producing hybrid antibodies containing human variable regions and constant regions from rodents (2002) (0)
Inhibition of Corneal Neovascularization and Inflammation by VEGF Trap (2002) (0)
Receptor antagonists based on IL-1 and methods of manufacture and use. (2003) (0)
Abstract 2644: In vivo and in vitro stem cell models suggest a role for LGR5 in regulating intestinal epithelial lineage specification. (2013) (0)
Placental Growth Factor (PlGF) Deficiency Reduces Pathological Angiogenesis in a Mouse Model of Matrigel Induced Choriodal Neovascularization (CNV) (2010) (0)
Novel approaches for modeling C3 glomerulopathy in mouse and rat (2018) (0)
The Discovery and Characterization of Neurotrophic and Myotrophic Factors (1996) (0)
Neurotrophic factor derived from the brain (1990) (0)
Pharmacological blockade of interleukin 6 receptor (IL-6R) inhibits the development of ocular inflammation in the murine model of experimental autoimmune uveitis (EAU) (2013) (0)
Production process of brain-derived neurotrophic factor (BDNF) means for the same, and pharmaceutical compositions (1990) (0)
Systemic Administration of a Murine Interleukin-1 (mIL-1) Trap Inhibits Suture-Induced Corneal Angiogenesis in the Mouse (2008) (0)
Position and use methods (2003) (0)
and Infection-Induced Intestinal γ Augments CD4+ T Cell Production of IFN- β Goblet Cell-Derived Resistin-Like Molecule (2013) (0)
Development of the VEGF Trap as a Novel Antiangiogenic Treatment Currently in Clinical Trials for Cancer and Eye Diseases, and Discovery of the Next Generation of Angiogenesis Targets (2007) (0)
Novel Non-invasive in vivo Quantification of Ocular Inflammation using Optical Coherence Tomography in Mice (2013) (0)
OP0028 Effects of Sarilumab plus MTX on Clinical, Radiographic, and Functional Endpoints in Patients with Moderate-To-Severe Rheumatoid Arthritis: Results of A Phase 3, Randomized, Double-Blind, Placebo-Controlled, International Study (2014) (0)
A UNTRAINED for the production of hybrid antibodies with human variable regions and constant regions of a rodent rodent (2002) (0)
Vascular Integrity by Angiopoietin-Like 4 Protection Against Myocardial Infarction and No-Reflow Through Preservation of (2011) (0)

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