Georgette D. Kanmogne
Researcher
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Biology
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(Suggest an Edit or Addition)According to Wikipedia, Georgette D. Kanmogne is a Cameroonian American geneticist and molecular virologist and a full professor and vice chair for resource allocation and faculty development within the Department of Pharmacology and Experimental Neurosciences at the University of Nebraska Medical Center in Omaha, Nebraska. Kanmogne's research program focuses on exploring the pathogenesis of neuroAIDS by deciphering the mechanisms underlying blood brain barrier dysfunction and viral entry into the central nervous system. Her research also addresses the lack of HIV therapies that cross the blood brain barrier and has played a critical role in the development of nanoparticles encapsulating HIV-drugs that can cross the BBB to prevent viral-mediated neuron death in the brain. Kanmogne collaborates with clinical and basic researchers across America, Cameroon, and West Africa, spanning disciplines from hematology to psychiatry, to explore how viral genetic diversity is correlated with the neurological impact of HIV.
Georgette D. Kanmogne's Published Works
Published Works
- Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions (2006) (756)
- HIV-1 gp120 Compromises Blood–Brain Barrier Integrity and Enhance Monocyte Migration across Blood–Brain Barrier: Implication for Viral Neuropathogenesis (2007) (234)
- HIV-1 gp120 Proteins Alter Tight Junction Protein Expression and Brain Endothelial Cell Permeability: Implications for the Pathogenesis of HIV-Associated Dementia (2005) (147)
- Maraviroc: a review of its use in HIV infection and beyond (2015) (135)
- STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. (2008) (128)
- Induction of apoptosis and endothelin-1 secretion in primary human lung endothelial cells by HIV-1 gp120 proteins. (2005) (117)
- NanoART synthesis, characterization, uptake, release and toxicology for human monocyte-macrophage drug delivery. (2009) (114)
- Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages. (2011) (107)
- HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling. (2009) (90)
- HIV‐1 gp120 Proteins and gp160 Peptides Are Toxic to Brain Endothelial Cells and Neurons: Possible Pathway for HIV Entry into the Brain and HIV‐Associated Dementia (2002) (85)
- HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon (2010) (83)
- Creation of a long-acting nanoformulated dolutegravir (2018) (78)
- Adherence to Antiretroviral Therapy (ART) in Yaoundé-Cameroon: Association with Opportunistic Infections, Depression, ART Regimen and Side Effects (2017) (76)
- HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: New insights into blood–brain barrier dysfunction for HIV-1-associated dementia (2007) (66)
- Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice. (2012) (66)
- HIV-1 Activates Proinflammatory and Interferon-Inducible Genes in Human Brain Microvascular Endothelial Cells: Putative Mechanisms of Blood—Brain Barrier Dysfunction (2008) (58)
- Risk factors for HIV-associated neurocognitive disorders (HAND) in sub-Saharan Africa: The case of Yaoundé-Cameroon (2009) (58)
- Detection of Trypanosoma brucei gambiense, in serologically positive but aparasitaemic sleeping-sickness suspects in Cameroon, by PCR. (1996) (55)
- Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells (2012) (54)
- Analysis of human lung endothelial cells for susceptibility to HIV type 1 infection, coreceptor expression, and cytotoxicity of gp120 protein. (2001) (53)
- Comparative manufacture and cell-based delivery of antiretroviral nanoformulations (2011) (50)
- Blood-borne macrophage-neural cell interactions hitchhike on endosome networks for cell-based nanozyme brain delivery. (2012) (44)
- NeuroAIDS in Africa (2010) (39)
- Cross‐talk between STAT1 and PI3K/AKT signaling in HIV‐1‐induced blood–brain barrier dysfunction: Role of CCR5 and implications for viral neuropathogenesis (2010) (34)
- Wide variation in DNA content among isolates of Trypanosoma brucei ssp. (1997) (31)
- The isolation and genetic heterogeneity of Trypanosoma brucei gambiense from north-west Uganda. (1993) (30)
- Noninfectious pulmonary complications of HIV/AIDS (2005) (29)
- Differential Effects of Tat Proteins Derived from HIV-1 Subtypes B and Recombinant CRF02_AG on Human Brain Microvascular Endothelial Cells: Implications for Blood–Brain Barrier Dysfunction (2014) (28)
- Global NeuroAIDS Roundtable (2013) (26)
- Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage (2011) (26)
- Genetic heterogeneity in the Trypanosoma brucei gambiense genome analysed by random amplification of polymorphic DNA (1996) (25)
- STAT 1 signaling modulates HIV-1 – induced inflammatory responses and leukocyte transmigration across the blood-brain barrier (2007) (25)
- Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication. (2016) (25)
- Characterization of Trypanosoma brucei gambiense isolates using restriction fragment length polymorphisms in 5 variant surface glycoprotein genes. (1996) (24)
- Analysis of human endothelial cells and cortical neurons for susceptibility to HIV-1 infection and co-receptor expression. (2000) (24)
- A successful backcross in Trypanosoma brucei. (1995) (23)
- Is HIV involved in the pathogenesis of non-infectious pulmonary complications in infected patients? (2003) (23)
- Dysregulation of claudin-5 in HIV-induced interstitial pneumonitis and lung vascular injury. Protective role of peroxisome proliferator-activated receptor-γ. (2014) (23)
- Depressive symptoms in HIV-infected and seronegative control subjects in Cameroon: Effect of age, education and gender (2017) (21)
- Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaoundé, Cameroon (2017) (21)
- Toll-Like Receptor-3 Mediates HIV-1-Induced Interleukin-6 Expression in the Human Brain Endothelium via TAK1 and JNK Pathways: Implications for Viral Neuropathogenesis (2018) (20)
- Lipid Peroxidation and Total Cholesterol in HAART-Naïve Patients Infected with Circulating Recombinant Forms of Human Immunodeficiency Virus Type-1 in Cameroon (2013) (19)
- Proceedings from the NIMH symposium on “NeuroAIDS in Africa: neurological and neuropsychiatric complications of HIV” (2016) (18)
- HIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood–brain barrier interactions: modulatory role of CCR5 (2014) (17)
- Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery. (2018) (15)
- Differential Mechanisms of Inflammation and Endothelial Dysfunction by HIV-1 Subtype-B and Recombinant CRF02_AG Tat Proteins on Human Brain Microvascular Endothelial Cells: Implications for Viral Neuropathogenesis (2018) (15)
- Effects of HIV on executive function and verbal fluency in Cameroon (2018) (14)
- Distribution of CD4+ T-lymphocytes levels in patients with clinical symptoms of AIDS in three west African countries. (1998) (12)
- Variability in HIV-1 Integrase Gene and 3′-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy (2020) (10)
- Infection of baboon microglia with SIV-HIV recombinant viruses: role of CD4 and chemokine receptors. (2002) (9)
- Molecular and Genetic Characterization of HIV-1 Tat Exon-1 Gene from Cameroon Shows Conserved Tat HLA-Binding Epitopes: Functional Implications (2016) (8)
- Attention/Working Memory, Learning and Memory in Adult Cameroonians: Normative Data, Effects of HIV Infection and Viral Genotype (2020) (8)
- CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice (2021) (7)
- Near-Full-Length Genetic Characterization of a Novel HIV-1 Unique Recombinant with Similarities to A1, CRF01_AE, and CRFO2_AG Viruses in Yaoundé, Cameroon. (2019) (4)
- Effects of HIV infection, antiretroviral therapy, and immune status on the speed of information processing and complex motor functions in adult Cameroonians (2020) (4)
- Epigenetics, N-myrystoyltransferase-1 and casein kinase-2-alpha modulates the increased replication of HIV-1 CRF02_AG, compared to subtype-B viruses (2019) (4)
- Human T-cell leukaemia/lymphoma virus type I infection in West African patients with clinical AIDS. (1998) (3)
- SARS-CoV-2 Spike Proteins and Cell–Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy Pathogenesis (2022) (3)
- Data in support of NFκB and JNK pathways involvement in TLR3-mediated HIV-1 transactivation, expression of IL-6 and transcription factors associated with HIV-1 replication (2015) (2)
- Monocyte-Macrophages and Viral Central Nervous System Entry (2011) (2)
- Toll-Like Receptor-3 Mediates HIV-1-Induced Interleukin-6 Expression in the Human Brain Endothelium via TAK1 and JNK Pathways: Implications for Viral Neuropathogenesis (2017) (1)
- leukocyte transmigration across the blood-brain barrier STAT1 signaling modulates HIV-1-induced inflammatory responses and (2013) (1)
- Polymerase Chain Reaction (PCR) and Real-Time PCR (2014) (1)
- HIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood–brain barrier interactions: modulatory role of CCR5 (2014) (1)
- Epigenetics, N-myrystoyltransferase-1 and casein kinase-2-alpha modulates the increased replication of HIV-1 CRF02_AG, compared to subtype-B viruses (2019) (0)
- Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaoundé, Cameroon (2017) (0)
- Differential Mechanisms of Inflammation and Endothelial Dysfunction by HIV-1 Subtype-B and Recombinant CRF02_AG Tat Proteins on Human Brain Microvascular Endothelial Cells: Implications for Viral Neuropathogenesis (2017) (0)
- Proceedings from the NIMH symposium on “NeuroAIDS in Africa: neurological and neuropsychiatric complications of HIV” (2016) (0)
- Author's reply. (2016) (0)
- Creation of a long-acting nanoformulated dolutegravir (2018) (0)
- Global NeuroAIDS Roundtable (2013) (0)
- CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice (2021) (0)
- Re:Short-term maraviroc exposure, a clinical approach to decide on maraviroc prescription in HIV-1-infected treatment-naïve patients (2016) (0)
- Effects of HIV on executive function and verbal fluency in Cameroon (2018) (0)
- FP49-TH-03 Risk factors for possible HIV-associated dementia (HAD) in Sub-Saharan Africa: the case of Yaoundé– Cameroon (2009) (0)
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