Gerald Crabtree

Q: What Schools Are Affiliated With Gerald Crabtree

Gerald Crabtree is affiliated with the following schools: University of California, Berkeley, Stanford University, Temple University, Harvard University

Gerald Crabtree's AcademicInfluence.com Rankings

Gerald Crabtree

Biology

#1510

World Rank

#2513

Historical Rank

#747

USA Rank

Biochemistry

#294

World Rank

#359

Historical Rank

#127

USA Rank

biology Degrees

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Biology

Gerald Crabtree's Degrees

PhD Biochemistry Stanford University
Bachelors Chemistry University of California, Berkeley

Why Is Gerald Crabtree Influential?

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According to Wikipedia, Gerald R. Crabtree is the David Korn Professor at Stanford University and an Investigator in the Howard Hughes Medical Institute. He is known for defining the Ca2+-calcineurin-NFAT signaling pathway, pioneering the development of synthetic ligands for regulation of biologic processes and discovering chromatin regulatory mechanisms involved in cancer and brain development. He is a founder of Ariad Pharmaceuticals, Amplyx Pharmaceuticals, and Foghorn Therapeutics.

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Gerald Crabtree's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation (1992) (1618)
The mechanism of action of cyclosporin A and FK506. (1992) (1569)
NFAT Signaling Choreographing the Social Lives of Cells (2002) (1347)
The mechanism of action of cyclosporin A and FK506. (1996) (1208)
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases (1992) (1120)
Contingent genetic regulatory events in T lymphocyte activation. (1989) (1053)
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A (1991) (1037)
lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin (1994) (1006)
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy (2013) (999)
Chromatin remodelling during development (2010) (993)
MicroRNA-mediated conversion of human fibroblasts to neurons (2011) (911)
Identification of a putative regulator of early T cell activation genes. (1988) (895)
A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. (2000) (829)
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms (2011) (797)
Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3 (1997) (794)
Generic Signals and Specific Outcomes Signaling through Ca2+, Calcineurin, and NF-AT (1999) (784)
Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling (1998) (735)
Diversity and specialization of mammalian SWI/SNF complexes. (1996) (715)
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor (1984) (701)
Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. (1991) (696)
Signal transmission between the plasma membrane and nucleus of T lymphocytes. (1994) (689)
An Essential Switch in Subunit Composition of a Chromatin Remodeling Complex during Neural Development (2007) (687)
MEDULLOBLASTOMA EXOME SEQUENCING UNCOVERS SUBTYPE-SPECIFIC SOMATIC MUTATIONS (2012) (686)
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest (1994) (673)
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum (1998) (667)
BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription (1993) (665)
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21 (2006) (648)
Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. (1990) (634)
Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. (1989) (622)
Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation. (1979) (585)
NF-AT components define a family of transcription factors targeted in T-cell activation (1994) (584)
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase (1992) (579)
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression (1996) (578)
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics (2015) (571)
Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. (1994) (553)
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons (1999) (518)
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency (2009) (515)
Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. (1990) (508)
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development (2009) (492)
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction (1998) (453)
Controlling signal transduction with synthetic ligands. (1993) (451)
Calcium, Calcineurin, and the Control of Transcription* (2001) (436)
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. (1997) (424)
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network (2009) (422)
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. (1997) (419)
A transcriptional hierarchy involved in mammalian cell-type specification (1992) (418)
Signals Transduced by Ca2+/Calcineurin and NFATc3/c4 Pattern the Developing Vasculature (2001) (418)
Characterization of antigen receptor response elements within the interleukin-2 enhancer (1988) (418)
Nuclear actin and actin-related proteins in chromatin remodeling. (2002) (415)
Neurotrophins and Netrins Require Calcineurin/NFAT Signaling to Stimulate Outgrowth of Embryonic Axons (2003) (392)
Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters. (1987) (387)
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. (1998) (376)
From neural development to cognition: unexpected roles for chromatin (2013) (375)
Dynamics and Memory of Heterochromatin in Living Cells (2012) (374)
Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes (2007) (373)
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation (2002) (372)
Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function (2006) (367)
Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma (2013) (356)
Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex. (1993) (352)
Understanding the Words of Chromatin Regulation (2009) (352)
Calcineurin/NFAT signaling in osteoblasts regulates bone mass. (2006) (324)
A Field of Myocardial-Endocardial NFAT Signaling Underlies Heart Valve Morphogenesis (2004) (318)
The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. (1990) (312)
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin (1995) (311)
Dimerization as a regulatory mechanism in signal transduction. (1998) (301)
Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. (1990) (291)
Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion. (1985) (279)
Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location (1993) (268)
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro. (1991) (268)
T-lymphocyte-antigen interactions in transplant rejection. (1990) (268)
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer. (2016) (264)
Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters. (1988) (259)
HNF-1, a member of a novel class of dimerizing homeodomain proteins. (1991) (259)
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes (2002) (259)
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. (1996) (245)
esBAF Facilitates Pluripotency by Conditioning the Genome for LIF/STAT3Signalingand by Regulating Polycomb Function (2011) (245)
The Actin Cytoskeleton and Lymphocyte Activation (1999) (241)
Searching for a function for nuclear actin. (2000) (240)
HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. (1990) (236)
Glucocorticoid-induced inhibition of T cell growth factor production. II. The effect on the in vitro generation of cytolytic T cells. (1979) (235)
Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. (2006) (232)
Dimeric ligands define a role for transcriptional activation domains in reinitiation (1996) (228)
Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex (2002) (223)
Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics (2004) (221)
Calcineurin B1 is essential for positive but not negative selection during thymocyte development. (2004) (220)
Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. (1991) (215)
NFAT signaling in vertebrate development. (2001) (214)
Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation (2009) (212)
The Neuron-specific Chromatin Regulatory Subunit BAF53b is Necessary for Synaptic Plasticity and Memory (2013) (211)
Cell signaling can direct either binary or graded transcriptional responses (2001) (204)
Lymphocyte calcium signaling from membrane to nucleus (2005) (199)
Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels (1995) (195)
Dynamics of BAF- Polycomb Complex Opposition on Heterochromatin in Normal and Oncogenic States (2016) (193)
NFAT signaling and the invention of vertebrates. (2007) (191)
Genetic Loss of Calcineurin Blocks Mechanical Overload-induced Skeletal Muscle Fiber Type Switching but Not Hypertrophy* (2004) (191)
The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. (2013) (186)
Chemically induced proximity in biology and medicine (2018) (185)
mSWI/SNF (BAF) Complexes Facilitate Decatentation of DNA by Topoisomerase IIα (2013) (184)
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. (2005) (181)
Engineering the ABA Plant Stress Pathway for Regulation of Induced Proximity (2011) (180)
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. (2004) (180)
Glucocorticoid receptors and glucocorticoid sensitivity of mitogen stimulated and unstimulated human lymphocytes (1977) (178)
Chromatin regulatory mechanisms in pluripotency. (2010) (174)
NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity (*) (1995) (174)
MicroRNAs: regulators of neuronal fate. (2013) (171)
Evolution and organization of the human protein C gene. (1986) (170)
Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. (1998) (170)
The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells (2009) (165)
Renaming the DSCR1 / Adapt78 gene family as RCAN: regulators of calcineurin (2007) (163)
Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. (2006) (162)
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development (2009) (159)
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. (2003) (158)
Harnessing Chaperones to Generate Small-Molecule Inhibitors of Amyloid ß Aggregation (2004) (158)
Negative regulation of interleukin 2 transcription by the glucocorticoid receptor (1992) (157)
ATP-dependent chromatin remodeling in neural development (2009) (153)
Calcineurin: a central controller of signalling in eukaryotes (2004) (151)
Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells (1986) (150)
Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization (1996) (147)
Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin (2016) (146)
Identification of a polymorphic, neuron-specific chromatin remodeling complex. (2002) (144)
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. (2017) (142)
Exome sequencing to identify de novo mutations in sporadic ALS trios (2013) (140)
Chemical rescue of cleft palate and midline defects in conditional GSK-3β mice (2007) (140)
A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor (1987) (139)
The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface. (2000) (137)
The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs. (1985) (137)
Three-part inventions: intracellular signaling and induced proximity. (1996) (132)
Signal transduction in T lymphocytes using a conditional allele of Sos. (1995) (130)
Calcineurin Is a Key Signaling Enzyme in T Lymphocyte Activation and the Target of the Immunosuppressive Drugs Cyclosporin A and FK506 a (1993) (129)
Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes. (1993) (128)
Conditional protein alleles using knockin mice and a chemical inducer of dimerization. (2003) (125)
Calcium signalling in lymphocytes. (2003) (124)
Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. (2004) (123)
The adenovirus major late transcription factor activates the rat gamma-fibrinogen promoter. (1987) (119)
Organization of the rat γ-fibrinogen gene: Alternative mRNA splice patterns produce the γA and γB (γ′) chains of fibrinogen (1982) (119)
The role of BAF (mSWI/SNF) complexes in mammalian neural development (2014) (119)
Protein Kinase A Negatively Modulates the Nuclear Accumulation of NF-ATc1 by Priming for Subsequent Phosphorylation by Glycogen Synthase Kinase-3* (2002) (116)
Rapid targeting of nuclear proteins to the cytoplasm (1997) (113)
Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes. (1994) (113)
Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins. (1992) (113)
Continuous and widespread roles for the Swi–Snf complex in transcription (1999) (112)
brg1: a putative murine homologue of the Drosophila brahma gene, a homeotic gene regulator. (1994) (111)
Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40. (1991) (110)
Rapid and reversible epigenome editing by endogenous chromatin regulators (2017) (109)
Glucocorticoid receptors and sensitivity of isolated human leukemia and lymphoma cells. (1978) (109)
A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF‐1. (1988) (108)
Evolutionary relationships among Rel domains indicate functional diversification by recombination (2001) (105)
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. (1990) (104)
The calcineurin phosphatase complex modulates immunogenic B cell responses. (2006) (103)
Potential basis for regulation of the coordinately expressed fibrinogen genes: homology in the 5' flanking regions. (1984) (102)
Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. (2012) (101)
Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc (1997) (101)
Dominant-negative SMARCA4 missense mutations alter the accessibility landscape of tissue-unrestricted enhancers (2017) (100)
Fas signal transduction triggers either proliferation or apoptosis in human fibroblasts. (1997) (98)
Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT). (2001) (97)
ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4. (2013) (95)
The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function. (2012) (93)
SnapShot: Ca2+-Calcineurin-NFATSignaling (2009) (90)
T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells. (1984) (90)
Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor. (1990) (89)
Lymphokine-induced phagocytosis in angiocentric immunoproliferative lesions (AIL) and malignant lymphoma arising in AIL. (1985) (89)
Kinetic Analysis of npBAF to nBAF Switching Reveals Exchange of SS18 with CREST and Integration with Neural Developmental Pathways (2013) (89)
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance. (2014) (89)
Structure of the human gamma-fibrinogen gene. Alternate mRNA splicing near the 3' end of the gene produces gamma A and gamma B forms of gamma-fibrinogen. (1984) (82)
Thymocyte Negative Selection Is Mediated by Protein Kinase C- and Ca2+-Dependent Transcriptional Induction of Bim1 (2006) (79)
Molecular cloning of cDNA for the alpha, beta, and gamma chains of rat fibrinogen. A family of coordinately regulated genes. (1981) (79)
Redundant expression but selective utilization of nuclear factor of activated T cells family members. (1997) (78)
Glucocorticoids inhibit expression of Fc receptors on the human granulocytic cell line HL-60 (1979) (77)
Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerization. (1996) (76)
Proximity and orientation underlie signaling by the non‐receptor tyrosine kinase ZAP70 (1997) (71)
A general strategy for producing conditional alleles of Src-like tyrosine kinases. (1995) (70)
Isolation of mutant T lymphocytes with defects in capacitative calcium entry. (1995) (70)
Evolution and structure of the fibrinogen genes. Random insertion of introns or selective loss? (1985) (67)
Glucocorticoids and immune responses. (1979) (67)
Calcineurin sets the bandwidth for discrimination of signals during thymocyte development (2007) (65)
Proximity versus allostery: the role of regulated protein dimerization in biology. (1994) (65)
Induction of fibrinogen and a subset of acute phase response genes involves a novel monokine which is mimicked by phorbol esters. (1987) (63)
TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin (2017) (63)
Role of Transcription Factor NFAT in Glucose and Insulin Homeostasis (2006) (63)
From neural development to cognition: unexpected roles for chromatin (2013) (60)
Recruitment of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Signaling Pathway to the NFATc4 Transcription Activation Complex (2005) (59)
Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase. (1997) (59)
Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications. (1983) (58)
Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator. (1995) (56)
Calcineurin/Nfat signaling is required for perinatal lung maturation and function. (2006) (56)
Glucocorticoids and lymphocytes. II. Cell cycle-dependent changes in glucocorticoid receptor content. (1980) (54)
DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes (2017) (54)
Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. (2019) (53)
Regulation of the interleukin-2 gene. (1992) (53)
Our fragile intellect. Part I. (2013) (53)
Coordinate accumulation of the mRNAs for the alpha, beta, and gamma chains of rat fibrinogen following defibrination. (1982) (53)
Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces. (1999) (53)
A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2. (1985) (53)
Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale. (1997) (50)
MLC-conditioned media stimulate an increase in Fc receptors on human macrophages. (1981) (50)
Modulation of peripheral B cell tolerance by CD72 in a murine model. (2008) (50)
Creating a neural specific chromatin landscape by npBAF and nBAF complexes (2013) (49)
Dynamics of inherently bounded histone modification domains (2012) (49)
Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012. (1994) (48)
Glucocorticoid-induced lymphocyte death (1981) (48)
Selective Role of NFATc3 in Positive Selection of Thymocytes1 (2007) (46)
Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1α (2000) (46)
Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling. (2001) (46)
Rapamycin Inhibits p34cdc2 Expression and Arrests T Lymphocyte Proliferation at the G1/S Transition (1993) (46)
Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance. (1982) (45)
Sp1, a CAAT-binding factor, and the adenovirus major late promoter transcription factor interact with functional regions of the gamma-fibrinogen promoter (1988) (44)
Mechanisms of glucocorticoid-induced immunosuppression: inhibitory effects on expression of Fc receptors and production of T-cell growth factor. (1980) (43)
An ATF/CREB-binding site is essential for cell-specific and inducible transcription of the murine MIP-1 beta cytokine gene. (1995) (42)
Enhanced NFATc1 Nuclear Occupancy Causes T Cell Activation Independent of CD28 Costimulation1 (2007) (42)
Glucocorticoids and lymphocytes. I. Increased glucocorticoid receptor levels in antigen-stimulated lymphocytes. (1980) (41)
Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. (1998) (40)
Specific Triggering of the Fas Signal Transduction Pathway in Normal Human Keratinocytes* (1996) (40)
Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists. (1994) (40)
Regulation of the HNF-1 homeodomain proteins by DCoH. (1993) (39)
GREAT METALLOCLUSTERS IN ENZYMOLOGY (2005) (39)
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution (2020) (36)
Fc receptors of a human promyelocytic leukemic cell line: evidence for two types of receptors defined by binding of the staphylococcal protein A-IgG1 complex. (1980) (34)
A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation. (2021) (34)
Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected]. (2006) (34)
Rapid chromatin repression by Aire provides precise control of immune tolerance (2018) (33)
Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp. (1995) (32)
Immunophilins, ligands, and the control of signal transduction. (1995) (32)
Down Syndrome Critical Region-1 Is a Transcriptional Target of Nuclear Factor of Activated T Cells-c1 within the Endocardium during Heart Development* (2007) (32)
Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development. (1999) (32)
Rescue of Degradation‐Prone Mutants of the FK506‐Rapamycin Binding (FRB) Protein with Chemical Ligands (2007) (31)
Expression of the fibrinogen genes in rat megakaryocytes. (1986) (31)
The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo (2016) (31)
Protein acetylation: more than chromatin modification to regulate transcription. (1997) (30)
Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. (2018) (30)
Inositol Phosphates in the Nucleus (2000) (30)
Glucocorticoid receptors and actions in rat thymocytes and immunologically stimulated human peripheral lymphocytes. (1979) (29)
Hyperphenylalaninemia and Impaired Glucose Tolerance in Mice Lacking the Bifunctional DCoH Gene* (2002) (29)
The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance. (2017) (29)
Generation of BAF53b‐Cre transgenic mice with pan‐neuronal Cre activities (2015) (27)
FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo (2009) (27)
Second messenger control of chromatin remodeling (2003) (27)
DNA sequence of the 5' flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus. (1984) (27)
Screening for Inhibitors of an Essential Chromatin Remodeler in Mouse Embryonic Stem Cells by Monitoring Transcriptional Regulation (2012) (27)
Decoding Calcium Signaling (2005) (26)
Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains (2013) (26)
Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism (2020) (26)
Sonographic staging of the developmental status of mouse embryos in utero (2003) (25)
Identification of a putative regulator of early T cell activation genes. Science. 1988. 241: 202-205. (2010) (25)
Glucocorticoid receptors and in vitro responses to glucocorticoid in acute nonlymphocytic leukemia. (1981) (25)
Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2. (2004) (25)
The cytoskeleton in lymphocyte signaling. (2000) (24)
Our fragile intellect. Part II. (2013) (24)
Autoimmune Thrombocytopenia Purpura and Hashimoto's Thyroiditis (1975) (23)
An EZ mark to miss. (2008) (23)
Selective role of calcineurin in haematopoiesis and lymphopoiesis (2008) (22)
Chromatin Regulators Mediate Anthracycline Sensitivity in Breast Cancer (2019) (21)
The Role of HNF‐1 in Liver‐specific Gene Expression a (1989) (21)
The rat fibrinogen genes. Linkage of the A alpha and gamma chain genes. (1983) (21)
'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation. (2005) (21)
J RECOMBINATION : RAG PROTEINS , REPAIR FACTORS , AND REGULATION (2009) (20)
Regulation of the Interleukin-2 Gene (Part 1 of 2) (1992) (19)
Reprogramming human fibroblasts to neurons by recapitulating an essential microRNA-chromatin switch. (2013) (19)
LSH mediates gene repression through macroH2A deposition (2020) (19)
In vitro transcription faithfully reflecting T-cell activation requirements. (1992) (19)
Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of Bim of cell death. (2006) (18)
Organization of the rat gamma-fibrinogen gene: alternative mRNA splice patterns produce the gamma A and gamma B (gamma ') chains of fibrinogen. (1982) (18)
CHD8 dosage regulates transcription in pluripotency and early murine neural differentiation (2020) (17)
BAF subunit switching regulates chromatin accessibility to control cell cycle exit in the developing mammalian cortex (2021) (15)
Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD (2021) (14)
Transcription: Regulation of the regulators (2000) (14)
Nuclear Actin as Choreographer of Cell Morphology and Transcription (2007) (14)
The Transcriptional Paradox: Octamer Factors and B and T Cells (1997) (12)
Complex Y chromosome aberrations are a recurrent secondary event in radiation-induced murine acute myeloid leukaemia. (1995) (12)
Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT. (1994) (12)
Retroviral activation of interleukin 2 gene in a gibbon ape T cell lymphoma line (1986) (12)
Nucleotide sequence of the gamma chain gene of rat fibrinogen: conserved intronic sequences. (1987) (12)
Exploiting protein destruction for constructive use (2007) (11)
Increased ACTL6A Occupancy Within mSWI/SNF Chromatin Remodelers Drives Human Squamous Cell Carcinoma (2021) (11)
STIMULATION OF PHAGOCYTOSIS BY A T CELL LYMPHOMA-DERIVED LYMPHOKINE (1982) (11)
Chemically Regulated Transcription Factors Reveal the Persistence of Repressor-resistant Transcription after Disrupting Activator Function* (2000) (11)
HNF- 1 and HNF- 1 (vHNF- 1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro (2007) (11)
Bursting into the Nucleus (2008) (10)
Immunology. Decoding calcium signaling. (2005) (10)
Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes (2018) (10)
A Foxy tango with NFAT (2006) (10)
Our Fragile Intellect (2012) (10)
Calcineurin inhibitors and the generalization of the presenting protein strategy. (2001) (10)
Effects and receptors of glucocorticoids in rat thymus cells and human peripheral lymphocytes. (1978) (10)
Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing. (2020) (9)
Monster protein controls calcium entry and fights infection. (2008) (9)
Transcriptional activity of the gibbon ape leukemia virus in the interleukin 2 gene of MLA 144 cells. (1987) (8)
REGULATION AND CHARACTERIZATION OF THE mRNAs FOR THE Aα, Bβ AND γ CHAINS OF FIBRINOGEN (1983) (8)
Developmental biology: The early heart remodelled (2009) (8)
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers (2017) (8)
Perspectives: signal transduction. Inositol phosphates in the nucleus. (2000) (8)
40 Transcriptional Regulatory Mechanisms in Liver and Midgut Morphogenesis of Vertebrates and Invertebrates (1992) (7)
Structure of the Human ?-Fibrinogen Gene ALTERNATE mRNA SPLICING NEAR THE 3‘ END OF THE GENE PRODUCES yA AND yB FORMS OF (2001) (7)
Abstract PR05: Reversing the oncogenic roles of misdirected chromatin remodeling: Disruption of mSWI/SNF (BAF) complexes by the SS18-SSX fusion in human synovial sarcoma (2013) (6)
A General Non‐Radioactive ATPase Assay for Chromatin Remodeling Complexes (2017) (6)
Single-copy inverted repeats associated with regional genetic duplications in gamma fibrinogen and immunoglobulin genes. (1984) (6)
Engineering small molecule specificity in nearly identical cellular environments. (2007) (5)
mSWI/SNF promotes distal repression by titrating polycomb dosage (2020) (4)
Site of action of cyclosporine and FK 506 in the pathways of communication between the T-lymphocyte antigen receptor and the early activation genes. (1991) (4)
Inhibition of a Selective SWI/SNF Function Synergizes with ATR Inhibitors in Cancer Cell Killing (2019) (4)
Calcineurin/NFAT Signaling in Development and Function of the Nervous System (2006) (3)
Isolation and expression of complementary DNAs encoding the human interleukin 2 receptor. (1985) (3)
Calcineurin/NFATc signaling is required for neuregulin regulated Schwann cell differentiation (2008) (3)
Regulation and characterization of the mRNAs for the A alpha, B beta and gamma chains of fibrinogen. (1983) (3)
Erratum: Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of Bim of cell death (Journal of Immunology (2006) 176 (2299-2306)) (2006) (3)
Murine esBAF chromatin remodeling complex subunits BAF 250 a and Brg (2014) (2)
Our fragile intellect: response to Dr Mitchell. (2013) (2)
Genes for the dimerization cofactor of hepatocyte nuclear factor-1 alpha (DCOH) are on human and murine chromosomes 10. (1993) (2)
Letter: Autoimmune thrombocytopenia purpura and Hashimoto's thyroiditis. (1975) (2)
Partial mRNA sequences for human Aa , Bf 3 , and y fibrinogen chains : Evolutionary and functional implications ( multigene families / cDNA (2)
Identity of 4 a-carbinolamine dehydratase , a component of the phenylalanine hydroxylation system , and DCoH , a transregulator of homeodomain proteins ( phenylalanine hydroxylase / 4 a-hydroxytetrahydropterin dehydratase / tetrahydrobiopterin / hepatocyte nuclear factor la / homeodomain regulatory (2)
ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve (2022) (2)
Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome (2022) (1)
Increased dosage of DSCR1 and DYRK1A on chromosome 21 destabilizes NFAT regulation and accounts for Down syndrome phenotypes (2006) (1)
Workshop on the Calcium/Calcineurin/NFAT Pathway: Regulation and Function (2004) (1)
The Interaction of SWI/SNF with the Ribosome Regulates Translation and Confers Sensitivity to Translation Pathway Inhibitors in Cancers with Complex Perturbations (2022) (1)
Stringent control of NFATc1 nuclear occupancy is critical for maintaining balanced immune response (2007) (1)
HUMAN TRANSCRIPTION FACTOR NFATC DNA BINDING DOMAIN, NMR, 10 STRUCTURES (1997) (1)
Abstract 1313: Mutually exclusive somatic mutations in WNT pathway medulloblastomas reveal a critical interaction between DDX3X and SMARCA4 (2012) (1)
Antibody engineering: Research and application of genes encoding immunoglobulins (1994) (1)
Abstract 3023: Chromatin accessibility underlies the tumor suppressor role of BAF (mSWI/SNF) complexes in many human cancers (2015) (1)
Regulation of the Interleukin-2 Gene (Part 2 of 2) (1992) (1)
ARID1B is a Dosage-sensitive Regulator of Polycomb Repressive Complex Distribution and HOX Gene Regulation in Patient-derived Neural Progenitors (2021) (1)
Control of the early activation genes of T lymphocytes (1986) (1)
Nucleosome turnover is sufficient to establish varied histone methylation states (2018) (1)
Erratum: Nuclear actin as choreographer of cell morphology and transcription (Science (1710)) (2007) (1)
Defining CBX7-Dependent Chromatin Architecture with Rapid Small-Molecule Inhibition (2019) (0)
Monocyte fc receptors for immuno globulin g studied with monomeric iodine 125 labeled immuno globulin g 1 normal fcr expression in hla b 8 drw 3 individuals (1982) (0)
New method for detection and evaluation of biologically active molecules (1995) (0)
Abstract 2315: Reversible disruption of mSWI/SNF-like BAF complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. (2013) (0)
1993 APPLICATION FOR FULL MEMBERSHIP IN THE AMERICAN SOCIETY FOR MICROBIOLOGY 1325 (0)
T-cell growth factor: Complete nuc) organization of the gene in normal (gene structure/human DNA library screening/lymphokines/interleu (2016) (0)
O2-03-02 A strategy for using bifunctional drugs to inhibit amyloid aggregation (2004) (0)
Lower brain pH as a shared endophenotype of psychotic disorders (2016) (0)
Stringent control of NFATc 1 nuclear occupancy is critical for maintaining balanced immune response Research Article (2011) (0)
Activa tion of early gene expression in T lymphocytes by OCT-1 and an inducible protein OAP 0 (2017) (0)
Gluco corticoid hormone immune regulation control of thymus derived cell growth factor production (1979) (0)
Abstract SY24-03: Chromatin regulation in cancer (2014) (0)
Fibrinogen evolution - The structure and evolution of fibrinogen: The coiled coil region (1985) (0)
An exchange of alternative ATPases within BAF complexes accompanies the transition from hemopoietic stem cell quiescence to proliferation (2014) (0)
Rethinking our intellectual origins: response to Kalinka et al. (2013) (0)
Crystal structure of DCoH2, a paralog of DCoH, the Dimerization Cofactor of HNF-1 (2004) (0)
Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains (2013) (0)
The npBAF to nBAF Chromatin Switch Regulates Cell Cycle Exit in the Developing Mammalian Cortex (2020) (0)
Molecular Cloning and Expression of cDNAS Encoding the Human Interleukin-2 Receptor (1985) (0)
Molecular cloning of cDNA for the human interleukin-2 receptor. (1985) (0)
Abstract NG05: Chromatin accessibility underlies the tumor-suppression role of BAF (mSWI/SNF) complexes in many malignancies (2015) (0)
Bifunctional molecules based on the same therapies. (1999) (0)
MY CAREER IN MOLECULAR BIOLOGY (2005) (0)
Pillars Article: Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation. Science. 1989. 246: 1617-1620. (2018) (0)
mSWI/SNF interacts with the ribosome and its inhibition/mutations alter translation and sensitize to mTOR/PI3K inhibitors (2021) (0)
Rewiring Cancer Drivers to Activate Apoptosis (2022) (0)
Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP 70 of myristoylation was to bring the src-like tyrosine kinases (2013) (0)
Rapid chromatin repression by Aire provides precise control of immune tolerance (2018) (0)
Molecular Analysis of the Human Interleukin-2 Receptor (1985) (0)
Unlocking the Promise of Stem Cells (2013) (0)
Abstract 2108: Chromatin state as a mechanism of anthracycline response in breast cancer (2019) (0)
New method of identifying and examining molecules with bilogica activity. (1995) (0)
Subject Index, Vol. 68, 1995 (1995) (0)
Signaling via GSK-3 is required during midline skeletogenesis (2006) (0)
Role of Transcription Factor NFAT in Glucose and Insulin Homeostasis (cid:1) (2006) (0)
Transcriptional Induction of Bim-Dependent 2 + Protein Kinase Cand Ca Thymocyte Negative Selection Is Mediated by and (2006) (0)
CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH (2000) (0)
NF‐AT Transcription Complex (2002) (0)
Abstract PR08: mSWI/SNF (BAF) complexes facilitate decatentation of DNA by topoisomerase IIα (2013) (0)
Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice (2022) (0)
Small Molecule-Induced Proximity (2012) (0)
1 mSWI / SNF promotes polycomb repression both directly and through genome-wide 1 redistribution 2 3 (2020) (0)
Sa134 A CRISPR/CAS9-ENGINEERED ARID1A-DEFICIENT HUMAN GASTRIC CANCER ORGANOID MODEL REVEALS ESSENTIAL AND NON-ESSENTIAL MODES OF ONCOGENIC TRANSFORMATION (2021) (0)
Rapid and reversible epigenome editing by endogenous chromatin regulators (2017) (0)
Regulated intracellular association of proteins using cell-permeable synthetic ligands (1994) (0)
Glycoconjuges a specificite de sequence antagonistes de transcription (1994) (0)
Targeted genes regulated by the transcription and other biological functions (1995) (0)
Abstract 123: A CRISPR/Cas9-engineered ARID1A-deficient human gastric cancer organoid model reveals essential and non-essential modes of oncogenic transformation (2021) (0)
Reversing the oncogenic roles of misdirected chromatin remodeling: Mechanistic insights into the SS18-SSX fusion protein in synovial sarcoma. (2013) (0)
Contents Vol. 68, 1999 (1999) (0)

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