Geraldine Seydoux
#54,369
Most Influential Person Now
American biologist
Geraldine Seydoux's AcademicInfluence.com Rankings
Geraldine Seydouxbiology Degrees
Biology
#3594
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#5471
Historical Rank
Molecular Biology
#965
World Rank
#988
Historical Rank
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Biology
Geraldine Seydoux's Degrees
- PhD Molecular Biology University of California, San Francisco
- Bachelors Biology University of California, Santa Cruz
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Why Is Geraldine Seydoux Influential?
(Suggest an Edit or Addition)According to Wikipedia, Geraldine C. Seydoux is a Professor of Molecular Biology and Genetics , the Huntington Sheldon Professor in Medical Discovery , and the Vice Dean for Basic Research at Johns Hopkins University. She is also a Howard Hughes Medical Institute Investigator. In 2002, Discover magazine recognized her as one of the 50 most important women in science.
Geraldine Seydoux's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution (2014) (1469)
- High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes (2015) (456)
- Pathway to Totipotency: Lessons from Germ Cells (2006) (402)
- 3′ UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline (2008) (356)
- PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans. (2001) (348)
- Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans. (1994) (341)
- Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster. (1997) (338)
- nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans. (1999) (338)
- Repression of gene expression in the embryonic germ lineage of C. elegans (1996) (323)
- RNA granules in germ cells. (2011) (305)
- Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans (2014) (298)
- Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases (2003) (281)
- Scalable and Versatile Genome Editing Using Linear DNAs with Microhomology to Cas9 Sites in Caenorhabditis elegans (2014) (275)
- Regulation of the Oocyte-to-Zygote Transition (2007) (248)
- Cell autonomy of lin-12 function in a cell fate decision in C. elegans (1989) (230)
- Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains. (2000) (211)
- Spindle Dynamics and the Role of γ-Tubulin in Early Caenorhabditis elegans Embryos (2001) (202)
- Polarization of the anterior–posterior axis of C. elegans is a microtubule-directed process (2000) (186)
- Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation (2003) (183)
- Metaphase to Anaphase (mat) Transition–Defective Mutants inCaenorhabditis elegans (2000) (174)
- Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3 (2016) (170)
- Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans (1990) (164)
- unc-3, a gene required for axonal guidance in Caenorhabditis elegans, encodes a member of the O/E family of transcription factors. (1998) (160)
- Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans (2017) (150)
- Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans. (2003) (148)
- Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks (2017) (144)
- Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos. (2008) (143)
- Stabilization of cell polarity by the C. elegans RING protein PAR-2. (2006) (142)
- Spindle dynamics and the role of gamma-tubulin in early Caenorhabditis elegans embryos. (2001) (138)
- Launching the germline in Caenorhabditis elegans: regulation of gene expression in early germ cells. (1999) (137)
- Loss-of-function genetic tools for animal models: cross-species and cross-platform differences (2016) (136)
- Anterior-Posterior Polarity in C. elegans and Drosophila--PARallels and Differences (2002) (135)
- Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. (1991) (133)
- Conserved Regulation of MAP Kinase Expression by PUF RNA-Binding Proteins (2007) (132)
- Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. (1999) (130)
- Regulation of MBK-2/DYRK by CDK-1 and the Pseudophosphatases EGG-4 and EGG-5 during the Oocyte-to-Embryo Transition (2009) (129)
- Cytoplasmic Partitioning of P Granule Components Is Not Required to Specify the Germline in C. elegans (2010) (122)
- Dedifferentiation of Primary Spermatocytes into Germ Cell Tumors in C. elegans Lacking the Pumilio-like Protein PUF-8 (2003) (117)
- Less is more: specification of the germline by transcriptional repression (2008) (115)
- Regulation of the MEX-5 Gradient by a Spatially Segregated Kinase/Phosphatase Cycle (2011) (115)
- A gel phase promotes condensation of liquid P granules in C. elegans embryos (2019) (115)
- Genetic requirements for PIE-1 localization and inhibition of gene expression in the embryonic germ lineage of Caenorhabditis elegans. (1998) (114)
- Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2 (2010) (113)
- The germline in C. elegans: origins, proliferation, and silencing. (2001) (107)
- A clean start: degradation of maternal proteins at the oocyte-to-embryo transition. (2004) (107)
- The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates. (2018) (104)
- Mechanisms of translational control in early development. (1996) (102)
- cdk-7 is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos (2002) (101)
- The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation (2006) (101)
- Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes (2011) (99)
- Cas9-assisted recombineering in C. elegans: genome editing using in vivo assembly of linear DNAs (2016) (85)
- Microtubules induce self-organization of polarized PAR domains in C. elegans zygotes (2011) (82)
- Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline. (2006) (82)
- Whole-mount in situ hybridization for the detection of RNA in Caenorhabditis elegans embryos. (1995) (81)
- Isolation and characterization of mutations causing abnormal eversion of the vulva in Caenorhabditis elegans. (1993) (80)
- Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans (1990) (72)
- Transgenic solutions for the germline* (2010) (72)
- P Granules Protect RNA Interference Genes from Silencing by piRNAs. (2019) (72)
- The PAR network: redundancy and robustness in a symmetry-breaking system (2013) (71)
- Germ cell specification. (2013) (70)
- Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins (2020) (67)
- Inhibition of Transcription by the Caenorhabditis elegans Germline Protein PIE-1: Genetic Evidence for Distinct Mechanisms Targeting Initiation and Elongation (2008) (64)
- Regulation of biomolecular condensates by interfacial protein clusters (2021) (63)
- Regulation of MBK-2/Dyrk Kinase by Dynamic Cortical Anchoring during the Oocyte-to-Zygote Transition (2007) (62)
- The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells (2012) (60)
- The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules (2010) (58)
- Report 3 0 UTRs Are the Primary Regulators of Gene Expression in the C . elegans Germline (57)
- The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells (2010) (54)
- Phase Separation in Biology and Disease. (2018) (53)
- Author Correction: A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos (2020) (45)
- The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules (2010) (37)
- Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B (2017) (36)
- Puromycin reactivity does not accurately localize translation at the subcellular level (2020) (32)
- Scalable and versatile genome editing using linear DNAs with micro-homology to Cas9 sites in C. elegans (2014) (25)
- P granules (2014) (25)
- Identification of Suppressors of mbk-2/DYRK by Whole-Genome Sequencing (2013) (18)
- MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes (2017) (17)
- 1 High efficiency , homology-directed genome editing in C . elegans using CRISPR / Cas 9 ribonucleoprotein complexes (2015) (16)
- Spatial regulation of the polarity kinase PAR-1 by parallel inhibitory mechanisms (2019) (14)
- Gastrulation in the nematode Caenorhabditis elegans (1994) (12)
- Dynamics of mRNA entry into stress granules (2019) (11)
- Nuage condensates: accelerators or circuit breakers for sRNA silencing pathways? (2021) (10)
- Phase separation in biology and disease—a symposium report (2019) (9)
- Protein-based condensation mechanisms drive the assembly of RNA-rich P granules (2021) (8)
- Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double‐Stranded DNA Donors (2019) (7)
- The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates (2022) (7)
- Recruitment of mRNAs to P granules by gelation with intrinsically-disordered proteins (2019) (5)
- Not just Salk (2017) (5)
- Single-molecule study reveals the frenetic lives of proteins in gradients (2018) (5)
- Author response: Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans (2014) (4)
- A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos (2019) (4)
- MIP-MAP: High Throughput Mapping of Caenorhabditis elegans Temperature Sensitive Mutants via Molecular Inversion Probes (2017) (3)
- Multiple mechanisms prevent ectopic condensation of FG nucleoporins in the cytoplasm (2022) (3)
- Two parallel sRNA amplification cycles contribute to RNAi inheritance in C. elegans (2021) (3)
- Pickering stabilization of a dynamic intracellular emulsion (2021) (3)
- Revisiting the role of microtubules in C. elegans polarity (2007) (3)
- Improving the specificity of nucleic acid detection with endonuclease-actuated degradation (2022) (2)
- Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos (2022) (2)
- Surfing the actomyosin wave: polarization of the C. elegans zygote. (2004) (2)
- Liquid-like P granules require ATP hydrolysis to avoid solidification (2018) (2)
- Recombineering in C. elegans: genome editing using in vivo assembly of linear DNAs (2016) (2)
- Cytoplasmic nucleoporin foci are stress-sensitive, non-essential condensates in C. elegans (2022) (2)
- Specification of the germline by Nanos-dependent down-regulation of the somatic synMuvB transcription factor LIN-15B (2017) (2)
- Analysis of P granules in vivo and ex vivo (2018) (2)
- Cell-free reconstitution of multi-condensate assemblies. (2021) (2)
- 'Goldilocks' suppressor screen identifies web of polarity regulators (2012) (2)
- Organelles without membranes: intrinsically‐disordered proteins bring order to the cytoplasm (2017) (1)
- Author response: Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B (2017) (1)
- P granules protect RNA interference genes from silencing by piRNAs (2019) (1)
- Toti "potent" repressors. (2006) (1)
- Sperm granules mediate epigenetic inheritance (2022) (1)
- [Table], Table 4: Traditional cloning vectors for embryonic expression (2005) (0)
- Figure 3, Step 2: Assembly of transformation-ready transgene (LR reaction) (2005) (0)
- Figure 1, The choice of the ORF can affect the final observed pattern (2005) (0)
- Fire Lab Vector Kit- June 1995 (updated to August 1996) Credits: Making & Testing New Vectors: Si-Qun Xu Vector Design, Strategic Mistakes, Late Night Gel Photos: Andy Fire Analysis of mRNA localization, lacZ in early embryos, pes-10 promoter: (2005) (0)
- Author response: Protein-based condensation mechanisms drive the assembly of RNA-rich P granules (2021) (0)
- The 2006 Genetics Society of America Medal (2006) (0)
- Mechanisms of Nuclear Pore Complex disassembly by the mitotic Polo-Like Kinase 1 (PLK-1) in C. elegans embryos (2023) (0)
- Author response: Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins (2020) (0)
- Coordination of RNA and protein condensation by the P granule protein MEG-3 (2020) (0)
- Germ Granules in Worms, Flies, and Other Organisms (2016) (0)
- RNA Granules in Germ Cells service (2011) (0)
- RNA granules: functional compartments or incidental condensates? (2023) (0)
- Transitions in the framework of condensate biology. (2023) (0)
- [Table], Table 2: 3'UTRs with different expression patterns in the germline (2005) (0)
- [Table], Table 3: Selected Destination Vectors (2005) (0)
- Figure 2, Step 1: Assembly of Entry Clone (BP reaction) (2005) (0)
- Figure 6, Troubleshooting the BP reaction when using large or low-yield PCR products. (2005) (0)
- [Table, Choosing the promoter]. (2005) (0)
- A fast, marker-free method to mutate, tag, or delete any gene using lin- ear DNAs with short homology arms (2014) (0)
- [Table], Table 5 (2005) (0)
- par-1 allele update: b274 is a premature stop and encodes a delocalized but active kinase (2009) (0)
- [Table], Table 1: Selected Entry Clones (2005) (0)
- Dynamics of mRNA entry into stress granules (2019) (0)
- RNA Granules: Liquids or Active Condensates? (2018) (0)
- Examination of P granule dynamics in vivo and ex vivo (2018) (0)
- Figure 4, attB sites in final constructs (2005) (0)
- Embryo emergent: elucidating the cell biology of development (2000) (0)
- Figure 5, Inclusion of attB1 linker between GFP and ORF can affect distribution of fusion protein. (2005) (0)
- Bi-Chang Chen high spatiotemporal resolution Lattice light-sheet microscopy : Imaging molecules to embryos at (2014) (0)
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