Gerard D. Wright

Gerard D. Wright's AcademicInfluence.com Rankings

Gerard D. Wright

Chemistry

#1956

World Rank

#2784

Historical Rank

Chemical Engineering

#154

World Rank

#168

Historical Rank

Organic Chemistry

#272

World Rank

#332

Historical Rank

chemistry Degrees

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Chemistry

Gerard D. Wright's Degrees

PhD Chemistry University of California, Berkeley
Masters Chemical Engineering Stanford University

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Gerard D. Wright's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Antibiotic resistance—the need for global solutions (2013) (3086)
Antibiotic resistance is ancient (2011) (1847)
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database (2016) (1612)
Sampling the Antibiotic Resistome (2006) (1367)
Antibacterial drug discovery in the resistance era (2016) (1362)
The Comprehensive Antibiotic Resistance Database (2013) (1349)
The antibiotic resistome: the nexus of chemical and genetic diversity (2007) (1142)
Bacterial resistance to antibiotics: enzymatic degradation and modification. (2005) (753)
Antibiotic resistance in the environment: a link to the clinic? (2010) (665)
Minimum Information about a Biosynthetic Gene cluster. (2015) (600)
Antibiotic Resistance Is Prevalent in an Isolated Cave Microbiome (2012) (589)
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. (1991) (583)
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. (2011) (429)
Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions. (2013) (402)
Drug combinations: a strategy to extend the life of antibiotics in the 21st century (2019) (393)
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance (2014) (371)
Antibiotic Adjuvants: Rescuing Antibiotics from Resistance. (2016) (356)
Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (2005) (289)
The tetracycline resistome (2010) (283)
Expanding the soil antibiotic resistome: exploring environmental diversity. (2007) (265)
TetX Is a Flavin-dependent Monooxygenase Conferring Resistance to Tetracycline Antibiotics* (2004) (260)
Something old, something new: revisiting natural products in antibiotic drug discovery. (2014) (232)
New strategies for combating multidrug-resistant bacteria. (2007) (224)
Structure of an Enzyme Required for Aminoglycoside Antibiotic Resistance Reveals Homology to Eukaryotic Protein Kinases (1997) (219)
The antibiotic resistance “mobilome”: searching for the link between environment and clinic (2013) (216)
Glycopeptide Antibiotic Resistance Genes in Glycopeptide-Producing Organisms (1998) (204)
Molecular mechanisms of antibiotic resistance. (2011) (198)
Resisting resistance: new chemical strategies for battling superbugs. (2000) (190)
Opportunities for natural products in 21st century antibiotic discovery. (2017) (188)
Antibiotic adjuvants: multicomponent anti-infective strategies (2011) (187)
Glycopeptide antibiotic resistance. (2003) (175)
Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams (2012) (175)
Assembling the glycopeptide antibiotic scaffold: The biosynthesis of from Streptomyces toyocaensis NRRL15009 (2002) (170)
New targets and screening approaches in antimicrobial drug discovery. (2005) (168)
Tigecycline is modified by the flavin-dependent monooxygenase TetX. (2005) (166)
Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture (2020) (163)
Identifying producers of antibacterial compounds by screening for antibiotic resistance (2013) (162)
Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole (2011) (160)
Q&A: Antibiotic resistance: where does it come from and what can we do about it? (2010) (155)
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. (2010) (148)
Bacterial proteases, untapped antimicrobial drug targets (2016) (147)
Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr (2008) (144)
An ecological perspective of microbial secondary metabolism. (2011) (143)
The antibiotic resistome: what's new? (2014) (143)
Antibiotic resistance is ancient: implications for drug discovery. (2012) (143)
Antibiotics: a new hope. (2012) (141)
Bacterial resistance to aminoglycoside antibiotics. (1971) (141)
Influence of Humans on Evolution and Mobilization of Environmental Antibiotic Resistome (2013) (141)
Glycopeptide antibiotic biosynthesis (2013) (141)
Aminoglycoside-modifying enzymes. (1999) (140)
Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. (1993) (135)
Introduction: antibiotic resistance. (2005) (134)
Aminoglycoside antibiotics. Structures, functions, and resistance. (1998) (133)
Aminoglycoside phosphotransferases: proteins, structure, and mechanism. (1999) (132)
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling (2020) (131)
Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance (2004) (129)
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium (2015) (127)
The genomic enzymology of antibiotic resistance. (2010) (127)
Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold. (1999) (126)
A diverse intrinsic antibiotic resistome from a cave bacterium (2016) (121)
Chemical biology of tetracycline antibiotics. (2008) (121)
Combinatorial strategies for combating invasive fungal infections (2017) (118)
Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci (1992) (118)
A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor. (2010) (118)
The Prehistory of Antibiotic Resistance. (2016) (117)
Antifungal Drugs: The Current Armamentarium and Development of New Agents. (2016) (116)
Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity. (1994) (113)
Lessons from the Environmental Antibiotic Resistome. (2017) (111)
Design of Bifunctional Antibiotics that Target Bacterial rRNA and Inhibit Resistance-Causing Enzymes (2000) (110)
The antibiotic resistome (2010) (107)
D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. (1997) (106)
Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147. (1995) (100)
Solving the Antibiotic Crisis. (2015) (98)
Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci. (1999) (97)
Unlocking the potential of natural products in drug discovery (2018) (96)
D-Alanyl-D-alanine ligases and the molecular mechanism of vancomycin resistance (1992) (92)
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase (2011) (91)
AMA overcomes antibiotic resistance by NDM and VIM metallo-β-lactamases (2014) (90)
Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors* (1997) (89)
Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147 (1992) (84)
Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium (1997) (83)
Streptogramin antibiotics: mode of action and resistance. (2002) (83)
Molecular Mechanism of Avibactam-Mediated β-Lactamase Inhibition. (2015) (82)
Aminoglycoside antibiotic phosphotransferases are also serine protein kinases. (1999) (81)
Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in Salmonella Typhimurium (2013) (81)
Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility. (2004) (80)
Analysis of the pi-pi stacking interactions between the aminoglycoside antibiotic kinase APH(3')-IIIa and its nucleotide ligands. (2002) (79)
Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes. (2018) (79)
Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes. (2003) (78)
Kinetic Mechanism of Aminoglycoside Phosphotransferase Type IIIa (1995) (77)
Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning. (2015) (75)
Inhibitors of metallo-β-lactamases. (2017) (74)
Mechanism and diversity of the erythromycin esterase family of enzymes. (2012) (74)
Bacterial inactivation of the anticancer drug doxorubicin. (2012) (74)
Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. (2015) (73)
Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB. (2009) (71)
A Common Platform for Antibiotic Dereplication and Adjuvant Discovery. (2017) (69)
Mechanisms of resistance to antibiotics. (2003) (69)
Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. (2006) (67)
A forward chemical screen identifies antibiotic adjuvants in Escherichia coli. (2012) (65)
Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity. (2003) (63)
Molecular Mechanism of Aminoglycoside Antibiotic Kinase APH(3′)-IIIa (2001) (63)
Antibiotic resistance: it’s bad, but why isn’t it worse? (2017) (61)
A small molecule discrimination map of the antibiotic resistance kinome. (2011) (60)
Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants* (2008) (60)
Antibiotic Resistance by Enzyme Inactivation: From Mechanisms to Solutions (2010) (59)
Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis. (2001) (59)
An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens. (2015) (58)
Forces shaping the antibiotic resistome (2014) (57)
Inactivation of the Lipopeptide Antibiotic Daptomycin by Hydrolytic Mechanisms (2011) (56)
The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents. (2021) (55)
Cystathionine β-Lyase Is Important for Virulence of Salmonella enterica Serovar Typhimurium (2004) (55)
Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance (2019) (54)
Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2''). (2004) (53)
An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis. (2006) (53)
One-pot chemoenzymatic preparation of coenzyme A analogues. (2004) (53)
Role of Homoserine Transacetylase as a New Target for Antifungal Agents (2007) (53)
Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics (2019) (52)
Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1 (2010) (52)
Diversity-oriented synthesis and preliminary biological screening of highly substituted five-membered lactones and lactams originating from an allyboration of aldehydes and imines. (2009) (49)
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. (2013) (49)
Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop. (2002) (49)
Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases (2000) (49)
A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria (2014) (48)
Transformation of the Anticancer Drug Doxorubicin in the Human Gut Microbiome. (2018) (47)
Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets. (2020) (47)
Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. (2016) (46)
Catalytic mechanism of enterococcal kanamycin kinase (APH(3')-IIIa): viscosity, thio, and solvent isotope effects support a Theorell-Chance mechanism. (1996) (45)
Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae. (2015) (45)
Vancomycin-Variable Enterococci Can Give Rise to Constitutive Resistance during Antibiotic Therapy (2014) (44)
Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations. (2009) (44)
Antimicrobial Resistance and Respiratory Infections (2018) (43)
Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function. (2007) (42)
Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia (2015) (42)
Small-Molecule Modulators of Listeria monocytogenes Biofilm Development (2011) (41)
Palmitoyl‐dl‐Carnitine is a Multitarget Inhibitor of Pseudomonas aeruginosa Biofilm Development (2011) (41)
Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7. (2017) (41)
Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases. (2005) (40)
Capturing the Resistome: a Targeted Capture Method To Reveal Antibiotic Resistance Determinants in Metagenomes (2019) (40)
Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity (2012) (40)
Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A. (2016) (40)
Regiospecificity of aminoglycoside phosphotransferase from Enterococci and Staphylococci (APH(3')-IIIa). (1996) (39)
Nucleotide Selectivity of Antibiotic Kinases (2010) (38)
Diversity of Integron- and Culture-Associated Antibiotic Resistance Genes in Freshwater Floc (2012) (38)
The COOH Terminus of Aminoglycoside Phosphotransferase (3′)-IIIa Is Critical for Antibiotic Recognition and Resistance* (1999) (37)
Rifampin phosphotransferase is an unusual antibiotic resistance kinase (2016) (37)
Characterization of a Rifampin-Inactivating Glycosyltransferase from a Screen of Environmental Actinomycetes (2012) (36)
On the Road to Bacterial Cell Death (2007) (36)
StoPK‐1, a serine/threonine protein kinase from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009, affects oxidative stress response (2002) (36)
Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action. (2018) (36)
Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL. (2006) (36)
Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivation. (2004) (36)
An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria. (2014) (35)
Antibiotics: An irresistible newcomer (2015) (35)
The past, present, and future of antibiotics (2022) (35)
Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase (2007) (35)
Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones. (2014) (35)
Heterologous expression-facilitated natural products’ discovery in actinomycetes (2019) (35)
The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III (2008) (34)
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. (2013) (34)
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes (2018) (34)
Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics. (2009) (34)
When Antibiotics Fail: The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada (2019) (33)
Novel approaches to discovery of antibacterial agents (2008) (31)
The origins of antibiotic resistance. (2012) (31)
Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin. (2001) (31)
Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups (1996) (30)
A molecular portrait of maternal sepsis from Byzantine Troy (2017) (30)
Environmental and clinical antibiotic resistomes, same only different. (2019) (30)
Evolving medicinal chemistry strategies in antibiotic discovery. (2016) (30)
Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA‐Specified Leu‐tRNAUUA Molecule (2015) (30)
Receptor domains of two-component signal transduction systems. (2011) (30)
Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure-Activity Relationships. (2016) (29)
Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (beta-lactones). (1998) (28)
Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ. (2013) (28)
Mechanism of aminoglycoside 3'-phosphotransferase type IIIa: His188 is not a phosphate-accepting residue. (1996) (27)
Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium. (2004) (27)
Microwave-assisted synthesis of N1- and C3-substituted pyrazolo[3,4-d]pyrimidine libraries (2011) (27)
Catalytic mechanism of fungal homoserine transacetylase. (2005) (26)
Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme*♦ (2010) (26)
Antibiotic Adjuvants: Rescuing Antibiotics from Resistance: (Trends in Microbiology 24, 862-871; October 17, 2016). (2016) (26)
Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster (2014) (26)
Mechanisms of Aminoglycoside Antibiotic Resistance (2007) (26)
Non-sterol structural probes of the lanosterol 14α-demethylase from Saccharomyces cerevisiae. (1990) (25)
Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites. (2014) (25)
β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents (2011) (25)
DdlN from Vancomycin-Producing Amycolatopsis orientalis C329.2 Is a VanA Homologue withd-Alanyl-d-Lactate Ligase Activity (1998) (25)
ARRANGEMENT OF SUBSTRATES AT THE ACTIVE SITE OF AN AMINOGLYCOSIDE ANTIBIOTIC 3'-PHOSPHOTRANSFERASE AS DETERMINED BY NMR (1996) (25)
The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both D-alanyl-D-alanine and D-alanyl-D-lactate ligases. (1997) (25)
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development (2020) (25)
Solution studies of isepamicin and conformational comparisons between isepamicin and butirosin A when bound to an aminoglycoside 6'-N-acetyltransferase determined by NMR spectroscopy. (1998) (25)
Crystal Structure of StaL, a Glycopeptide Antibiotic Sulfotransferase from Streptomyces toyocaensis* (2007) (25)
Accessorizing natural products: adding to nature's toolbox. (2005) (24)
A New Target for Antibiotic Development (2007) (24)
How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity. (2016) (24)
Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase. (2003) (23)
Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor. (2003) (23)
Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistance. (2005) (23)
Prospects for Antibacterial Discovery and Development. (2021) (23)
Perspective: Synthetic biology revives antibiotics (2014) (23)
Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics (2020) (23)
Determining the mode of action of bioactive compounds. (2012) (22)
Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer. (2001) (22)
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity. (2001) (22)
Active-site labeling of an aminoglycoside antibiotic phosphotransferase (APH(3')-IIIa). (1994) (22)
Making sense of antisense in antibiotic drug discovery. (2009) (21)
New phenolic inhibitors of yeast homoserine dehydrogenase. (2004) (20)
Functional annotation of putative aminoglycoside antibiotic modifying proteins in Mycobacterium tuberculosis H37Rv. (2003) (20)
Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function. (2016) (20)
The Molecular Basis of the Expansive Substrate Specificity of the Antibiotic Resistance Enzyme Aminoglycoside Acetyltransferase-6′-Aminoglycoside Phosphotransferase-2" (2003) (20)
Q&A: Antibiotic resistance: what more do we know and what more can we do? (2013) (19)
Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3')-IIIa]. (2005) (18)
Purification and Characterization of Two Haloperoxidases from the Glycopeptide Antibiotic ProducerStreptomyces toyocaensisNRRL 15009 (1996) (17)
Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli. (2010) (17)
Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors. (2001) (17)
How antibiotics kill bacteria: new models needed? (2013) (17)
The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor (2019) (17)
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies (2018) (17)
Glycopeptide Sulfation Evades Resistance (2012) (16)
GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery (2020) (16)
Spectinomycin Kinase from Legionella pneumophila (1998) (16)
Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics (2021) (16)
Superbugs: How they evolve and minimize the cost of resistance (1999) (15)
Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism. (1999) (15)
Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis. (2018) (15)
Biosynthetic gene cluster and antimicrobial activity of the elfamycin antibiotic factumycin (2012) (15)
Metal-induced isomerization yields an intracellular chelator that disrupts bacterial iron homeostasis. (2014) (14)
Alternative Pathway to a Glycopeptide-Resistant Cell Wall in the Balhimycin Producer Amycolatopsis balhimycina. (2015) (13)
Pharmacodynamics of dose-escalated ‘front-loading’ polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli (2017) (13)
Membrane interactions of non-membrane targeting antibiotics: The case of aminoglycosides, macrolides, and fluoroquinolones. (2020) (12)
Antibiotic Resistome: A Framework Linking the Clinic and the Environment (2011) (12)
Noncanonical Vancomycin Resistance Cluster from Desulfitobacterium hafniense Y51 (2009) (12)
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+ (2021) (12)
Draft Genome Sequence of the Sulfonamide Antibiotic-Degrading Microbacterium sp. Strain C448 (2014) (12)
Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold (2012) (12)
Identification of a common protease‐sensitive region in d‐alanyl‐d‐alanine and d‐alanyl‐d‐lactate ligases and photoaffinity labeling with 8‐azido ATP (1993) (12)
Role of PBPD1 in Stimulation of Listeria monocytogenes Biofilm Formation by Subminimal Inhibitory β-Lactam Concentrations (2014) (11)
Biochemical Logic of Antibiotic Inactivation and Modification (2009) (11)
Functionally important amino acids in Saccharomyces cerevisiae aspartate kinase. (2003) (10)
Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism (2016) (10)
Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity. (2020) (9)
Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation (2022) (8)
ClpP inhibitors are produced by a widespread family of bacterial gene clusters (2022) (8)
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics. (2021) (8)
Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D). (2015) (8)
Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner (2020) (8)
Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. (2017) (8)
Back to the future: a new ‘old’ lead for tuberculosis (2012) (8)
The Enzymes of the Rifamycin Antibiotic Resistome. (2021) (7)
Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase (2011) (7)
Purification and characterization of two haloperoxidases from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009. (1996) (7)
Problems with Co-Funding in Canada (2005) (7)
Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates. (2016) (6)
Aminoglycoside Resistance Mechanisms (2005) (6)
Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation (2022) (5)
Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide (2008) (5)
Antibiotics: inactive but not inert. (2010) (5)
Crystallization and preliminary X-ray crystallographic analysis of the tetracycline-degrading monooxygenase TetX2 from Bacteroides thetaiotaomicron. (2010) (5)
Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance (2021) (5)
Effects of iron binding agents on Saccharomyces cerevisiae growth and cytochrome P450 content. (1989) (5)
Antibiotic Resistance themed issue (2016) (5)
Natural Products in Antibiotic Discovery (2018) (5)
Winners of the 2014 JA Medals for excellence (2015) (5)
Empowering Older Antibiotics (2016) (4)
Structural Aspects of Aminoglycoside-Modifying Enzymes (2007) (4)
Investigation of lysine: N-hydroxylation in the biosynthesis of the siderophore aerobactin (1989) (4)
Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics (2022) (4)
Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance. (2019) (4)
Regulation of Glycopeptide Resistance Genes of Enterococcal Transposon Tn1546 by the VanR-VanS Two-Component Regulatory System (1995) (4)
Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A. (2016) (4)
CrpP Is Not a Fluoroquinolone-Inactivating Enzyme (2021) (4)
Biochemistry. A new target for antibiotic development. (2007) (3)
A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent. (2021) (3)
Induction and substrate specificity of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae Y222 (1991) (3)
Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae. (1998) (3)
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin (2021) (3)
HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics (2021) (3)
Ancient Antibiotics, Ancient Resistance (2021) (2)
Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine. (2004) (2)
Antibiotics: Bacterial Resistance (2008) (2)
Crystal Structure of Homoserine Transacetylase (2005) (2)
Redox Mechanisms and Reactive Oxygen Species in Antibiotic Action and Resistance (2011) (2)
New Targets and Screening Approaches in Antimicrobial Drug Discovery (2005) (2)
The future of fungi: threats and opportunities (2022) (2)
Diversity-Oriented Synthesis and Preliminary Biological Screening of Highly Substituted Five-Membered Lactones and Lactams Originating from an Allylboration of Aldehydes and Imines. (2009) (2)
Trichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance (2018) (2)
Synthesis and evaluation of photoaffinity probes directed at lanosterol 14α-demethylase (P-45014DM) (1992) (2)
Resistance to aminoglycoside Antibiotics: Function meets structure (2001) (1)
Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family (2021) (1)
The “Molecular Logic” Underlying Antibiotic Activity and Structure (2003) (1)
Dedication: Heinz Floss and Christopher Walsh—pioneers in natural product chemical biology (2019) (1)
Allostery trumps antibiotic resistance. (2005) (1)
d-Ala-d-Ala Carboxypeptidase VanY (2004) (1)
Structure of the tetracycline-degrading monooxygenase TetX2 (2010) (1)
Antibiotics adjuvants to extend the efficacy of legacy antibiotics (2015) (0)
Non-sterol structural probes of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae. (1990) (0)
CTX-M-15 in complex with FPI-1523 (2016) (0)
Crystal structure of aminoglycoside phosphotransferase APH(2")-Id/APH(2")-IVa (2010) (0)
Glycopeptide antibiotic discovery in the genomic era. (2022) (0)
A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity. (2021) (0)
Role of PBPD1 in Stimulation of Listeria monocytogenes Bioﬁlm Formation by Subminimal Inhibitory (cid:2) -Lactam Concentrations (2014) (0)
A single extracellular loop of FoxA controls ligand specificity, uptake, and signaling in Pseudomonas aeruginosa (2022) (0)
The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies (2017) (0)
Chapter 8 Biochemical Logic of Antibiotic Inactivation and Modifi cation (0)
Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis (2005) (0)
OXA-48 in complex with FPI-1465 (2016) (0)
Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation (2022) (0)
Structure of Streptogramin Acetyltransferase in Complex with an Inhibitor (2009) (0)
CTX-M-15 in complex with FPI-1602 (2016) (0)
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NA-PP1 (2012) (0)
Biotransformation of anticancer drugs by human and environmental microbiomes (2015) (0)
Q&A: Antibiotic resistance: what more do we know and what more can we do? (2013) (0)
Inhibition of an antibiotic resistance enzyme: crystal structure of aminoglycoside phosphotransferase APH(2")-Id/APH(2")-IVa in complex with kanamycin inhibited with quercetin (2012) (0)
Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2"")-Ia, apo form (2014) (0)
Structure of the TetX monooxygenase in complex with the substrate 7- chlortetracycline (2011) (0)
Resistance-guided antibiotic discovery (2015) (0)
Crystal structure of Rifampin ADP-ribosyl transferase in complex with Rifampin (2007) (0)
Crystallographic studies of homoserine dehydrogenase for the design of novel antifungal agents (1996) (0)
Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics (2019) (0)
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound (2011) (0)
The Antibiotic Resistome: Origins, Diversity, and Future Prospects (2011) (0)
Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia (2010) (0)
ClpP inhibitors are produced by a widespread family of bacterial gene clusters (2022) (0)
Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline (2003) (0)
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor tyrphostin AG1478 (2012) (0)
HOMOSERINE DEHYDROGENASE COMPLEX WITH NAD ANALOGUE AND L-HOMOSERINE (2000) (0)
HOMOSERINE DEHYDROGENASE FROM S. CEREVISIAE COMPLEX WITH NAD (2000) (0)
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes (2018) (0)
Crystal Structure of D,D-heptose 1.7-bisphosphate phosphatase from E. Coli. (2007) (0)
Antibiotic Dereplication Using the Antibiotic Resistance Platform. (2019) (0)
Towards unravelling the structure of an antibiotics-inactivating enzyme – kanamycin kinase (1996) (0)
First JA Medal goes to a paper on decalpenic acid (2012) (0)
Winners of the 2013 JA Medals for excellence (2014) (0)
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling (2020) (0)
Antimicrobials (2019) (0)
Canada has an opportunity to address antimicrobial resistance through COVID-19 recovery spending (2022) (0)
Christopher Walsh: Pioneer and innovator in antibiotic and natural product chemical biology (2014) (0)
Antibiotic resistance: it’s bad, but why isn’t it worse? (2017) (0)
Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family (2022) (0)
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor anthrapyrazolone SP600125 (2012) (0)
Crystal Structure of Escherichia Coli Phosphoheptose Isomerase (2007) (0)
aminoglycoside antibiotic activity by synthetic a-hydroxytropolones (2014) (0)
Drug combinations: a strategy to extend the life of antibiotics in the 21st century (2019) (0)
OXA-48 in complex with FPI-1523 (2016) (0)
Crystal structure of Escherichia coli phosphoheptose isomerase in complex with reaction substrate sedoheptulose 7-phosphate (2007) (0)
Structural basis of sulfonation of the glycopeptide antibiotic scaffold by the sulfotransferase StaL (2012) (0)
Aminoglycoside Addiction in Gram-Negative Bacteria (2008) (0)
CTX-M-15 in complex with FPI-1465 (2016) (0)
Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics (2020) (0)
Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complexed with rifampin and FAD (2017) (0)
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP2 (2012) (0)
Crystal structure of aminoglycoside resistance enzyme ApmA, complex with acetyl-CoA (2020) (0)
SP11-3 The environment as a source of antibiotic resistance (2013) (0)
Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction. (2023) (0)
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1 (2012) (0)
Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2"")-Ia, kanamycin-bound (2014) (0)
Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol (2004) (0)
Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complex with FAD (2017) (0)
Author response: A molecular portrait of maternal sepsis from Byzantine Troy (2016) (0)
OXA-48 in complex with FPI-1602 (2016) (0)
Aspergillomarsine from Aspergillus versicolor reduces antibiotic resistance in bacteria (2019) (0)
Structure of the Tetracycline degrading Monooxygenase TetX2 from Bacteroides thetaiotaomicron (2011) (0)
Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme. (2011) (0)
Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens. (2022) (0)
Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A (2022) (0)

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