Gerard D. Wright
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Gerard D. Wrightchemistry Degrees
Chemistry
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Chemistry
Gerard D. Wright's Degrees
- PhD Chemistry University of California, Berkeley
- Masters Chemical Engineering Stanford University
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(Suggest an Edit or Addition)Gerard D. Wright's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Antibiotic resistance—the need for global solutions (2013) (3086)
- Antibiotic resistance is ancient (2011) (1847)
- CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database (2016) (1612)
- Sampling the Antibiotic Resistome (2006) (1367)
- Antibacterial drug discovery in the resistance era (2016) (1362)
- The Comprehensive Antibiotic Resistance Database (2013) (1349)
- The antibiotic resistome: the nexus of chemical and genetic diversity (2007) (1142)
- Bacterial resistance to antibiotics: enzymatic degradation and modification. (2005) (753)
- Antibiotic resistance in the environment: a link to the clinic? (2010) (665)
- Minimum Information about a Biosynthetic Gene cluster. (2015) (600)
- Antibiotic Resistance Is Prevalent in an Isolated Cave Microbiome (2012) (589)
- Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. (1991) (583)
- Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. (2011) (429)
- Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions. (2013) (402)
- Drug combinations: a strategy to extend the life of antibiotics in the 21st century (2019) (393)
- Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance (2014) (371)
- Antibiotic Adjuvants: Rescuing Antibiotics from Resistance. (2016) (356)
- Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (2005) (289)
- The tetracycline resistome (2010) (283)
- Expanding the soil antibiotic resistome: exploring environmental diversity. (2007) (265)
- TetX Is a Flavin-dependent Monooxygenase Conferring Resistance to Tetracycline Antibiotics* (2004) (260)
- Something old, something new: revisiting natural products in antibiotic drug discovery. (2014) (232)
- New strategies for combating multidrug-resistant bacteria. (2007) (224)
- Structure of an Enzyme Required for Aminoglycoside Antibiotic Resistance Reveals Homology to Eukaryotic Protein Kinases (1997) (219)
- The antibiotic resistance “mobilome”: searching for the link between environment and clinic (2013) (216)
- Glycopeptide Antibiotic Resistance Genes in Glycopeptide-Producing Organisms (1998) (204)
- Molecular mechanisms of antibiotic resistance. (2011) (198)
- Resisting resistance: new chemical strategies for battling superbugs. (2000) (190)
- Opportunities for natural products in 21st century antibiotic discovery. (2017) (188)
- Antibiotic adjuvants: multicomponent anti-infective strategies (2011) (187)
- Glycopeptide antibiotic resistance. (2003) (175)
- Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams (2012) (175)
- Assembling the glycopeptide antibiotic scaffold: The biosynthesis of from Streptomyces toyocaensis NRRL15009 (2002) (170)
- New targets and screening approaches in antimicrobial drug discovery. (2005) (168)
- Tigecycline is modified by the flavin-dependent monooxygenase TetX. (2005) (166)
- Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture (2020) (163)
- Identifying producers of antibacterial compounds by screening for antibiotic resistance (2013) (162)
- Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole (2011) (160)
- Q&A: Antibiotic resistance: where does it come from and what can we do about it? (2010) (155)
- Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. (2010) (148)
- Bacterial proteases, untapped antimicrobial drug targets (2016) (147)
- Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr (2008) (144)
- An ecological perspective of microbial secondary metabolism. (2011) (143)
- The antibiotic resistome: what's new? (2014) (143)
- Antibiotic resistance is ancient: implications for drug discovery. (2012) (143)
- Antibiotics: a new hope. (2012) (141)
- Bacterial resistance to aminoglycoside antibiotics. (1971) (141)
- Influence of Humans on Evolution and Mobilization of Environmental Antibiotic Resistome (2013) (141)
- Glycopeptide antibiotic biosynthesis (2013) (141)
- Aminoglycoside-modifying enzymes. (1999) (140)
- Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. (1993) (135)
- Introduction: antibiotic resistance. (2005) (134)
- Aminoglycoside antibiotics. Structures, functions, and resistance. (1998) (133)
- Aminoglycoside phosphotransferases: proteins, structure, and mechanism. (1999) (132)
- Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling (2020) (131)
- Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance (2004) (129)
- Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium (2015) (127)
- The genomic enzymology of antibiotic resistance. (2010) (127)
- Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold. (1999) (126)
- A diverse intrinsic antibiotic resistome from a cave bacterium (2016) (121)
- Chemical biology of tetracycline antibiotics. (2008) (121)
- Combinatorial strategies for combating invasive fungal infections (2017) (118)
- Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci (1992) (118)
- A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor. (2010) (118)
- The Prehistory of Antibiotic Resistance. (2016) (117)
- Antifungal Drugs: The Current Armamentarium and Development of New Agents. (2016) (116)
- Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity. (1994) (113)
- Lessons from the Environmental Antibiotic Resistome. (2017) (111)
- Design of Bifunctional Antibiotics that Target Bacterial rRNA and Inhibit Resistance-Causing Enzymes (2000) (110)
- The antibiotic resistome (2010) (107)
- D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. (1997) (106)
- Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147. (1995) (100)
- Solving the Antibiotic Crisis. (2015) (98)
- Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci. (1999) (97)
- Unlocking the potential of natural products in drug discovery (2018) (96)
- D-Alanyl-D-alanine ligases and the molecular mechanism of vancomycin resistance (1992) (92)
- Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase (2011) (91)
- AMA overcomes antibiotic resistance by NDM and VIM metallo-β-lactamases (2014) (90)
- Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors* (1997) (89)
- Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147 (1992) (84)
- Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium (1997) (83)
- Streptogramin antibiotics: mode of action and resistance. (2002) (83)
- Molecular Mechanism of Avibactam-Mediated β-Lactamase Inhibition. (2015) (82)
- Aminoglycoside antibiotic phosphotransferases are also serine protein kinases. (1999) (81)
- Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in Salmonella Typhimurium (2013) (81)
- Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility. (2004) (80)
- Analysis of the pi-pi stacking interactions between the aminoglycoside antibiotic kinase APH(3')-IIIa and its nucleotide ligands. (2002) (79)
- Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes. (2018) (79)
- Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes. (2003) (78)
- Kinetic Mechanism of Aminoglycoside Phosphotransferase Type IIIa (1995) (77)
- Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning. (2015) (75)
- Inhibitors of metallo-β-lactamases. (2017) (74)
- Mechanism and diversity of the erythromycin esterase family of enzymes. (2012) (74)
- Bacterial inactivation of the anticancer drug doxorubicin. (2012) (74)
- Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. (2015) (73)
- Structure and mechanism of the lincosamide antibiotic adenylyltransferase LinB. (2009) (71)
- A Common Platform for Antibiotic Dereplication and Adjuvant Discovery. (2017) (69)
- Mechanisms of resistance to antibiotics. (2003) (69)
- Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. (2006) (67)
- A forward chemical screen identifies antibiotic adjuvants in Escherichia coli. (2012) (65)
- Kinetic mechanism of the GCN5-related chromosomal aminoglycoside acetyltransferase AAC(6')-Ii from Enterococcus faecium: evidence of dimer subunit cooperativity. (2003) (63)
- Molecular Mechanism of Aminoglycoside Antibiotic Kinase APH(3′)-IIIa (2001) (63)
- Antibiotic resistance: it’s bad, but why isn’t it worse? (2017) (61)
- A small molecule discrimination map of the antibiotic resistance kinome. (2011) (60)
- Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide Biosynthesis and a Target for Antibiotic Adjuvants* (2008) (60)
- Antibiotic Resistance by Enzyme Inactivation: From Mechanisms to Solutions (2010) (59)
- Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis. (2001) (59)
- An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens. (2015) (58)
- Forces shaping the antibiotic resistome (2014) (57)
- Inactivation of the Lipopeptide Antibiotic Daptomycin by Hydrolytic Mechanisms (2011) (56)
- The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents. (2021) (55)
- Cystathionine β-Lyase Is Important for Virulence of Salmonella enterica Serovar Typhimurium (2004) (55)
- Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance (2019) (54)
- Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2''). (2004) (53)
- An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis. (2006) (53)
- One-pot chemoenzymatic preparation of coenzyme A analogues. (2004) (53)
- Role of Homoserine Transacetylase as a New Target for Antifungal Agents (2007) (53)
- Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics (2019) (52)
- Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1 (2010) (52)
- Diversity-oriented synthesis and preliminary biological screening of highly substituted five-membered lactones and lactams originating from an allyboration of aldehydes and imines. (2009) (49)
- A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. (2013) (49)
- Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop. (2002) (49)
- Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases (2000) (49)
- A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria (2014) (48)
- Transformation of the Anticancer Drug Doxorubicin in the Human Gut Microbiome. (2018) (47)
- Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets. (2020) (47)
- Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. (2016) (46)
- Catalytic mechanism of enterococcal kanamycin kinase (APH(3')-IIIa): viscosity, thio, and solvent isotope effects support a Theorell-Chance mechanism. (1996) (45)
- Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae. (2015) (45)
- Vancomycin-Variable Enterococci Can Give Rise to Constitutive Resistance during Antibiotic Therapy (2014) (44)
- Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations. (2009) (44)
- Antimicrobial Resistance and Respiratory Infections (2018) (43)
- Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function. (2007) (42)
- Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia (2015) (42)
- Small-Molecule Modulators of Listeria monocytogenes Biofilm Development (2011) (41)
- Palmitoyl‐dl‐Carnitine is a Multitarget Inhibitor of Pseudomonas aeruginosa Biofilm Development (2011) (41)
- Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7. (2017) (41)
- Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases. (2005) (40)
- Capturing the Resistome: a Targeted Capture Method To Reveal Antibiotic Resistance Determinants in Metagenomes (2019) (40)
- Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity (2012) (40)
- Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A. (2016) (40)
- Regiospecificity of aminoglycoside phosphotransferase from Enterococci and Staphylococci (APH(3')-IIIa). (1996) (39)
- Nucleotide Selectivity of Antibiotic Kinases (2010) (38)
- Diversity of Integron- and Culture-Associated Antibiotic Resistance Genes in Freshwater Floc (2012) (38)
- The COOH Terminus of Aminoglycoside Phosphotransferase (3′)-IIIa Is Critical for Antibiotic Recognition and Resistance* (1999) (37)
- Rifampin phosphotransferase is an unusual antibiotic resistance kinase (2016) (37)
- Characterization of a Rifampin-Inactivating Glycosyltransferase from a Screen of Environmental Actinomycetes (2012) (36)
- On the Road to Bacterial Cell Death (2007) (36)
- StoPK‐1, a serine/threonine protein kinase from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009, affects oxidative stress response (2002) (36)
- Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action. (2018) (36)
- Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL. (2006) (36)
- Molecular mechanism of the enterococcal aminoglycoside 6'-N-acetyltransferase': role of GNAT-conserved residues in the chemistry of antibiotic inactivation. (2004) (36)
- An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria. (2014) (35)
- Antibiotics: An irresistible newcomer (2015) (35)
- The past, present, and future of antibiotics (2022) (35)
- Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase (2007) (35)
- Inhibition of the ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones. (2014) (35)
- Heterologous expression-facilitated natural products’ discovery in actinomycetes (2019) (35)
- The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III (2008) (34)
- Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. (2013) (34)
- The evolution of substrate discrimination in macrolide antibiotic resistance enzymes (2018) (34)
- Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics. (2009) (34)
- When Antibiotics Fail: The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada (2019) (33)
- Novel approaches to discovery of antibacterial agents (2008) (31)
- The origins of antibiotic resistance. (2012) (31)
- Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin. (2001) (31)
- Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups (1996) (30)
- A molecular portrait of maternal sepsis from Byzantine Troy (2017) (30)
- Environmental and clinical antibiotic resistomes, same only different. (2019) (30)
- Evolving medicinal chemistry strategies in antibiotic discovery. (2016) (30)
- Biosynthesis of the Fluorinated Natural Product Nucleocidin in Streptomyces calvus Is Dependent on the bldA‐Specified Leu‐tRNAUUA Molecule (2015) (30)
- Receptor domains of two-component signal transduction systems. (2011) (30)
- Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure-Activity Relationships. (2016) (29)
- Synthesis and inhibitory action on HMG-CoA synthase of racemic and optically active oxetan-2-ones (beta-lactones). (1998) (28)
- Self resistance to the atypical cationic antimicrobial peptide edeine of Brevibacillus brevis Vm4 by the N-acetyltransferase EdeQ. (2013) (28)
- Mechanism of aminoglycoside 3'-phosphotransferase type IIIa: His188 is not a phosphate-accepting residue. (1996) (27)
- Cystathionine beta-lyase is important for virulence of Salmonella enterica serovar Typhimurium. (2004) (27)
- Microwave-assisted synthesis of N1- and C3-substituted pyrazolo[3,4-d]pyrimidine libraries (2011) (27)
- Catalytic mechanism of fungal homoserine transacetylase. (2005) (26)
- Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme*♦ (2010) (26)
- Antibiotic Adjuvants: Rescuing Antibiotics from Resistance: (Trends in Microbiology 24, 862-871; October 17, 2016). (2016) (26)
- Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK‐68,597 Biosynthetic Cluster (2014) (26)
- Mechanisms of Aminoglycoside Antibiotic Resistance (2007) (26)
- Non-sterol structural probes of the lanosterol 14α-demethylase from Saccharomyces cerevisiae. (1990) (25)
- Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites. (2014) (25)
- β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents (2011) (25)
- DdlN from Vancomycin-Producing Amycolatopsis orientalis C329.2 Is a VanA Homologue withd-Alanyl-d-Lactate Ligase Activity (1998) (25)
- ARRANGEMENT OF SUBSTRATES AT THE ACTIVE SITE OF AN AMINOGLYCOSIDE ANTIBIOTIC 3'-PHOSPHOTRANSFERASE AS DETERMINED BY NMR (1996) (25)
- The glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009 has both D-alanyl-D-alanine and D-alanyl-D-lactate ligases. (1997) (25)
- Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development (2020) (25)
- Solution studies of isepamicin and conformational comparisons between isepamicin and butirosin A when bound to an aminoglycoside 6'-N-acetyltransferase determined by NMR spectroscopy. (1998) (25)
- Crystal Structure of StaL, a Glycopeptide Antibiotic Sulfotransferase from Streptomyces toyocaensis* (2007) (25)
- Accessorizing natural products: adding to nature's toolbox. (2005) (24)
- A New Target for Antibiotic Development (2007) (24)
- How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity. (2016) (24)
- Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase. (2003) (23)
- Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor. (2003) (23)
- Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistance. (2005) (23)
- Prospects for Antibacterial Discovery and Development. (2021) (23)
- Perspective: Synthetic biology revives antibiotics (2014) (23)
- Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics (2020) (23)
- Determining the mode of action of bioactive compounds. (2012) (22)
- Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer. (2001) (22)
- Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity. (2001) (22)
- Active-site labeling of an aminoglycoside antibiotic phosphotransferase (APH(3')-IIIa). (1994) (22)
- Making sense of antisense in antibiotic drug discovery. (2009) (21)
- New phenolic inhibitors of yeast homoserine dehydrogenase. (2004) (20)
- Functional annotation of putative aminoglycoside antibiotic modifying proteins in Mycobacterium tuberculosis H37Rv. (2003) (20)
- Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function. (2016) (20)
- The Molecular Basis of the Expansive Substrate Specificity of the Antibiotic Resistance Enzyme Aminoglycoside Acetyltransferase-6′-Aminoglycoside Phosphotransferase-2" (2003) (20)
- Q&A: Antibiotic resistance: what more do we know and what more can we do? (2013) (19)
- Establishing the principles of recognition in the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3')-IIIa]. (2005) (18)
- Purification and Characterization of Two Haloperoxidases from the Glycopeptide Antibiotic ProducerStreptomyces toyocaensisNRRL 15009 (1996) (17)
- Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli. (2010) (17)
- Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors. (2001) (17)
- How antibiotics kill bacteria: new models needed? (2013) (17)
- The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor (2019) (17)
- The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies (2018) (17)
- Glycopeptide Sulfation Evades Resistance (2012) (16)
- GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery (2020) (16)
- Spectinomycin Kinase from Legionella pneumophila (1998) (16)
- Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics (2021) (16)
- Superbugs: How they evolve and minimize the cost of resistance (1999) (15)
- Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism. (1999) (15)
- Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis. (2018) (15)
- Biosynthetic gene cluster and antimicrobial activity of the elfamycin antibiotic factumycin (2012) (15)
- Metal-induced isomerization yields an intracellular chelator that disrupts bacterial iron homeostasis. (2014) (14)
- Alternative Pathway to a Glycopeptide-Resistant Cell Wall in the Balhimycin Producer Amycolatopsis balhimycina. (2015) (13)
- Pharmacodynamics of dose-escalated ‘front-loading’ polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli (2017) (13)
- Membrane interactions of non-membrane targeting antibiotics: The case of aminoglycosides, macrolides, and fluoroquinolones. (2020) (12)
- Antibiotic Resistome: A Framework Linking the Clinic and the Environment (2011) (12)
- Noncanonical Vancomycin Resistance Cluster from Desulfitobacterium hafniense Y51 (2009) (12)
- Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+ (2021) (12)
- Draft Genome Sequence of the Sulfonamide Antibiotic-Degrading Microbacterium sp. Strain C448 (2014) (12)
- Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold (2012) (12)
- Identification of a common protease‐sensitive region in d‐alanyl‐d‐alanine and d‐alanyl‐d‐lactate ligases and photoaffinity labeling with 8‐azido ATP (1993) (12)
- Role of PBPD1 in Stimulation of Listeria monocytogenes Biofilm Formation by Subminimal Inhibitory β-Lactam Concentrations (2014) (11)
- Biochemical Logic of Antibiotic Inactivation and Modification (2009) (11)
- Functionally important amino acids in Saccharomyces cerevisiae aspartate kinase. (2003) (10)
- Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism (2016) (10)
- Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity. (2020) (9)
- Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation (2022) (8)
- ClpP inhibitors are produced by a widespread family of bacterial gene clusters (2022) (8)
- Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics. (2021) (8)
- Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D). (2015) (8)
- Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner (2020) (8)
- Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites. (2017) (8)
- Back to the future: a new ‘old’ lead for tuberculosis (2012) (8)
- The Enzymes of the Rifamycin Antibiotic Resistome. (2021) (7)
- Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase (2011) (7)
- Purification and characterization of two haloperoxidases from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009. (1996) (7)
- Problems with Co-Funding in Canada (2005) (7)
- Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates. (2016) (6)
- Aminoglycoside Resistance Mechanisms (2005) (6)
- Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation (2022) (5)
- Structure and Function of Sedoheptulose-7-phosphate Isomerase, a Critical Enzyme for Lipopolysaccharide (2008) (5)
- Antibiotics: inactive but not inert. (2010) (5)
- Crystallization and preliminary X-ray crystallographic analysis of the tetracycline-degrading monooxygenase TetX2 from Bacteroides thetaiotaomicron. (2010) (5)
- Identifying novel β-lactamase substrate activity through in silico prediction of antimicrobial resistance (2021) (5)
- Effects of iron binding agents on Saccharomyces cerevisiae growth and cytochrome P450 content. (1989) (5)
- Antibiotic Resistance themed issue (2016) (5)
- Natural Products in Antibiotic Discovery (2018) (5)
- Winners of the 2014 JA Medals for excellence (2015) (5)
- Empowering Older Antibiotics (2016) (4)
- Structural Aspects of Aminoglycoside-Modifying Enzymes (2007) (4)
- Investigation of lysine: N-hydroxylation in the biosynthesis of the siderophore aerobactin (1989) (4)
- Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics (2022) (4)
- Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance. (2019) (4)
- Regulation of Glycopeptide Resistance Genes of Enterococcal Transposon Tn1546 by the VanR-VanS Two-Component Regulatory System (1995) (4)
- Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A. (2016) (4)
- CrpP Is Not a Fluoroquinolone-Inactivating Enzyme (2021) (4)
- Biochemistry. A new target for antibiotic development. (2007) (3)
- A Screen of Natural Product Extracts Identifies Moenomycin as a Potent Antigonococcal Agent. (2021) (3)
- Induction and substrate specificity of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae Y222 (1991) (3)
- Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae. (1998) (3)
- ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin (2021) (3)
- HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics (2021) (3)
- Ancient Antibiotics, Ancient Resistance (2021) (2)
- Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine. (2004) (2)
- Antibiotics: Bacterial Resistance (2008) (2)
- Crystal Structure of Homoserine Transacetylase (2005) (2)
- Redox Mechanisms and Reactive Oxygen Species in Antibiotic Action and Resistance (2011) (2)
- New Targets and Screening Approaches in Antimicrobial Drug Discovery (2005) (2)
- The future of fungi: threats and opportunities (2022) (2)
- Diversity-Oriented Synthesis and Preliminary Biological Screening of Highly Substituted Five-Membered Lactones and Lactams Originating from an Allylboration of Aldehydes and Imines. (2009) (2)
- Trichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance (2018) (2)
- Synthesis and evaluation of photoaffinity probes directed at lanosterol 14α-demethylase (P-45014DM) (1992) (2)
- Resistance to aminoglycoside Antibiotics: Function meets structure (2001) (1)
- Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family (2021) (1)
- The “Molecular Logic” Underlying Antibiotic Activity and Structure (2003) (1)
- Dedication: Heinz Floss and Christopher Walsh—pioneers in natural product chemical biology (2019) (1)
- Allostery trumps antibiotic resistance. (2005) (1)
- d-Ala-d-Ala Carboxypeptidase VanY (2004) (1)
- Structure of the tetracycline-degrading monooxygenase TetX2 (2010) (1)
- Antibiotics adjuvants to extend the efficacy of legacy antibiotics (2015) (0)
- Non-sterol structural probes of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae. (1990) (0)
- CTX-M-15 in complex with FPI-1523 (2016) (0)
- Crystal structure of aminoglycoside phosphotransferase APH(2")-Id/APH(2")-IVa (2010) (0)
- Glycopeptide antibiotic discovery in the genomic era. (2022) (0)
- A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity. (2021) (0)
- Role of PBPD1 in Stimulation of Listeria monocytogenes Biofilm Formation by Subminimal Inhibitory (cid:2) -Lactam Concentrations (2014) (0)
- A single extracellular loop of FoxA controls ligand specificity, uptake, and signaling in Pseudomonas aeruginosa (2022) (0)
- The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies (2017) (0)
- Chapter 8 Biochemical Logic of Antibiotic Inactivation and Modifi cation (0)
- Streptogramins, Oxazolidinones, and Other Inhibitors of Bacterial Protein Synthesis (2005) (0)
- OXA-48 in complex with FPI-1465 (2016) (0)
- Capturing the antibiotic resistome of preterm infants reveals new benefits of probiotic supplementation (2022) (0)
- Structure of Streptogramin Acetyltransferase in Complex with an Inhibitor (2009) (0)
- CTX-M-15 in complex with FPI-1602 (2016) (0)
- Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NA-PP1 (2012) (0)
- Biotransformation of anticancer drugs by human and environmental microbiomes (2015) (0)
- Q&A: Antibiotic resistance: what more do we know and what more can we do? (2013) (0)
- Inhibition of an antibiotic resistance enzyme: crystal structure of aminoglycoside phosphotransferase APH(2")-Id/APH(2")-IVa in complex with kanamycin inhibited with quercetin (2012) (0)
- Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2"")-Ia, apo form (2014) (0)
- Structure of the TetX monooxygenase in complex with the substrate 7- chlortetracycline (2011) (0)
- Resistance-guided antibiotic discovery (2015) (0)
- Crystal structure of Rifampin ADP-ribosyl transferase in complex with Rifampin (2007) (0)
- Crystallographic studies of homoserine dehydrogenase for the design of novel antifungal agents (1996) (0)
- Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics (2019) (0)
- Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, ATP-bound (2011) (0)
- The Antibiotic Resistome: Origins, Diversity, and Future Prospects (2011) (0)
- Crystal structure of aminoglycoside phosphotransferase APH(4)-Ia (2010) (0)
- ClpP inhibitors are produced by a widespread family of bacterial gene clusters (2022) (0)
- Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline (2003) (0)
- Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor tyrphostin AG1478 (2012) (0)
- HOMOSERINE DEHYDROGENASE COMPLEX WITH NAD ANALOGUE AND L-HOMOSERINE (2000) (0)
- HOMOSERINE DEHYDROGENASE FROM S. CEREVISIAE COMPLEX WITH NAD (2000) (0)
- The evolution of substrate discrimination in macrolide antibiotic resistance enzymes (2018) (0)
- Crystal Structure of D,D-heptose 1.7-bisphosphate phosphatase from E. Coli. (2007) (0)
- Antibiotic Dereplication Using the Antibiotic Resistance Platform. (2019) (0)
- Towards unravelling the structure of an antibiotics-inactivating enzyme – kanamycin kinase (1996) (0)
- First JA Medal goes to a paper on decalpenic acid (2012) (0)
- Winners of the 2013 JA Medals for excellence (2014) (0)
- Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling (2020) (0)
- Antimicrobials (2019) (0)
- Canada has an opportunity to address antimicrobial resistance through COVID-19 recovery spending (2022) (0)
- Christopher Walsh: Pioneer and innovator in antibiotic and natural product chemical biology (2014) (0)
- Antibiotic resistance: it’s bad, but why isn’t it worse? (2017) (0)
- Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family (2022) (0)
- Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor anthrapyrazolone SP600125 (2012) (0)
- Crystal Structure of Escherichia Coli Phosphoheptose Isomerase (2007) (0)
- aminoglycoside antibiotic activity by synthetic a-hydroxytropolones (2014) (0)
- Drug combinations: a strategy to extend the life of antibiotics in the 21st century (2019) (0)
- OXA-48 in complex with FPI-1523 (2016) (0)
- Crystal structure of Escherichia coli phosphoheptose isomerase in complex with reaction substrate sedoheptulose 7-phosphate (2007) (0)
- Structural basis of sulfonation of the glycopeptide antibiotic scaffold by the sulfotransferase StaL (2012) (0)
- Aminoglycoside Addiction in Gram-Negative Bacteria (2008) (0)
- CTX-M-15 in complex with FPI-1465 (2016) (0)
- Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics (2020) (0)
- Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complexed with rifampin and FAD (2017) (0)
- Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP2 (2012) (0)
- Crystal structure of aminoglycoside resistance enzyme ApmA, complex with acetyl-CoA (2020) (0)
- SP11-3 The environment as a source of antibiotic resistance (2013) (0)
- Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction. (2023) (0)
- Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1 (2012) (0)
- Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2"")-Ia, kanamycin-bound (2014) (0)
- Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol (2004) (0)
- Crystal structure of rifampin monooxygenase from Streptomyces venezuelae, complex with FAD (2017) (0)
- Author response: A molecular portrait of maternal sepsis from Byzantine Troy (2016) (0)
- OXA-48 in complex with FPI-1602 (2016) (0)
- Aspergillomarsine from Aspergillus versicolor reduces antibiotic resistance in bacteria (2019) (0)
- Structure of the Tetracycline degrading Monooxygenase TetX2 from Bacteroides thetaiotaomicron (2011) (0)
- Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme. (2011) (0)
- Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens. (2022) (0)
- Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A (2022) (0)
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