Gerd Prof. Dr. Dr. Geißlinger

Gerd Prof. Dr. Dr. Geißlinger's AcademicInfluence.com Rankings

Chemistry

#2413

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#3319

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Organic Chemistry

#349

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#416

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Gerd Prof. Dr. Dr. Geißlinger

Philosophy

#5140

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#7869

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#2468

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#3464

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Chemistry
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Gerd Prof. Dr. Dr. Geißlinger's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Cyclooxygenase‐independent actions of cyclooxygenase inhibitors (2001) (768)
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence (2006) (543)
COX‐2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX‐2 inhibitor celecoxib (2001) (513)
Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. (2006) (467)
Chain length-specific properties of ceramides. (2012) (393)
Up‐regulation of cyclooxygenase‐2 mRNA in the rat spinal cord following peripheral inflammation (1996) (330)
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer (2008) (301)
Ziconotide for treatment of severe chronic pain (2010) (287)
Pharmacokinetics of Opioids in Liver Disease (1999) (264)
Genetic Predictors of the Clinical Response to Opioid Analgesics (2004) (241)
COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites. (2005) (224)
Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain (2014) (223)
Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers (2003) (217)
The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine. (2002) (207)
Opioids As Modulators of Cell Death and Survival—Unraveling Mechanisms and Revealing New Indications (2004) (203)
Capturing adenylyl cyclases as potential drug targets (2009) (200)
Ceramide synthases and ceramide levels are increased in breast cancer tissue. (2009) (189)
No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing (2009) (184)
The IKK‐NF‐κB pathway: a source for novel molecular drug targets in pain therapy? (2008) (184)
Incidence and Costs of Adverse Drug Reactions During Hospitalisation (2000) (176)
Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth. (2012) (174)
Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. (2004) (173)
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. (2006) (167)
FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells1 (2007) (160)
Celecoxib loses its anti‐inflammatory efficacy at high doses through activation of NF‐κB (2001) (159)
Specific Inhibition of IκB Kinase Reduces Hyperalgesia in Inflammatory and Neuropathic Pain Models in Rats (2004) (159)
Are mu-opioid receptor polymorphisms important for clinical opioid therapy? (2005) (156)
The μ-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers (2006) (154)
A Common Human μ-Opioid Receptor Genetic Variant Diminishes the Receptor Signaling Efficacy in Brain Regions Processing the Sensory Information of Pain* (2009) (153)
Does the A118G Polymorphism at the &mgr;-opioid Receptor Gene Protect against Morphine-6-Glucuronide Toxicity? (2002) (149)
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. (2007) (148)
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation. (2003) (146)
Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation. (1999) (141)
Targeting the beta‐catenin/APC pathway: a novel mechanism to explain the cyclooxygenase‐2‐independent anticarcinogenic effects of celecoxib in human colon carcinoma cells (2005) (137)
The effect of age on the pharmacokinetics and pharmacodynamics of midazolam (1999) (134)
Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons. (1992) (129)
Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method. (1993) (128)
Peripheral opioid analgesia in experimental human pain models. (2003) (125)
Stereoselective pharmacokinetics of ketamine: R(−)‐Ketamine inhibits the elimination of S(+)‐ketamine (2001) (125)
Current evidence for a genetic modulation of the response to analgesics (2006) (122)
Inhibition of Cyclooxygenases by Dipyrone (2007) (120)
Ceramides as Novel Disease Biomarkers. (2019) (119)
Differential Opioid Action on Sensory and Affective Cerebral Pain Processing (2008) (118)
Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. (2003) (116)
Release of sphingosine‐1‐phosphate from human platelets is dependent on thromboxane formation (2011) (110)
Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype (2008) (110)
Expression of cyclooxygenase isoforms in the rat spinal cord and their regulation during adjuvant-induced arthritis (1998) (110)
Epigenetics in pain and analgesia: An imminent research field (2011) (109)
Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers (2009) (109)
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia (2016) (108)
Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. (2003) (108)
Release of algesic substances in human experimental muscle pain (2002) (108)
Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution (2009) (105)
The Transfer Half-life of Morphine-6-glucuronide from Plasma to Effect Site Assessed by Pupil Size Measurement in Healthy Volunteers (2001) (105)
5,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent Terminals (2012) (105)
Effects of selective COX‐1 and ‐2 inhibition on formalin‐evoked nociceptive behaviour and prostaglandin E2 release in the spinal cord (2001) (104)
Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain (2004) (104)
Elevated Serum Cyclophilin Levels in Patients with Severe Sepsis (1997) (103)
Selective Antagonism of Opioid‐Induced Ventilatory Depression by an Ampakine Molecule in Humans Without Loss of Opioid Analgesia (2010) (102)
Genetic modulation of the pharmacological treatment of pain. (2009) (101)
Opioids for chronic non-cancer pain (2013) (100)
THP‐1 and human peripheral blood mononuclear cell‐derived macrophages differ in their capacity to polarize in vitro (2017) (99)
Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation (2001) (98)
Phenotyping the Function of TRPV1-Expressing Sensory Neurons by Targeted Axonal Silencing (2013) (98)
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. (2004) (97)
Quantitative characterization of prostaglandins in the uterus of early pregnant cattle. (2009) (97)
Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration (1999) (96)
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti‐inflammatory phenotype (2009) (96)
Tissue distribution of imipenem in critically ill patients (2002) (95)
Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action (2006) (95)
NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury (2012) (94)
Alterations in the Hippocampal Endocannabinoid System in Diet-Induced Obese Mice (2010) (93)
Microsomal Prostaglandin E2 Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction (2008) (91)
Morphine-6-Glucuronide (2001) (90)
Pharmacokinetics of Non-Intravenous Formulations of Fentanyl (2012) (90)
Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency. (1999) (89)
Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine‐6‐glucuronide in healthy volunteers (1996) (89)
cGMP Produced by NO-Sensitive Guanylyl Cyclase Essentially Contributes to Inflammatory and Neuropathic Pain by Using Targets Different from cGMP-Dependent Protein Kinase I (2008) (89)
Computerized surveillance of adverse drug reactions in hospital: Implementation (1999) (88)
The enigma of ceramide synthase regulation in mammalian cells. (2016) (86)
Modulation of central nervous system–specific microRNA-124a alters the inflammatory response in the formalin test in mice (2013) (85)
Lack of Analgesic Activity of Morphine‐6‐glucuronide after Short‐term Intravenous Administration in Healthy Volunteers (1997) (84)
Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. (2003) (83)
Comparative clinical effects of hydromorphone and morphine: a meta-analysis (2011) (83)
Relevance of frequent μ-opioid receptor polymorphisms for opioid activity in healthy volunteers (2006) (82)
Molecular cloning and expression of a 2-arylpropionyl-coenzyme A epimerase: a key enzyme in the inversion metabolism of ibuprofen. (1997) (81)
Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation? (2009) (80)
Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord (2000) (79)
Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test (1997) (79)
NOXious signaling in pain processing. (2013) (78)
Evidence for morphine‐independent central nervous opioid effects after administration of codeine: Contribution of other codeine metabolites (2006) (77)
R-Flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids (2010) (77)
Inhibition of prostaglandin E2 synthesis by SC‐560 is independent of cyclooxygenase 1 inhibition (2006) (77)
Activation of the AMP-activated protein kinase reduces inflammatory nociception. (2013) (76)
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. (2010) (76)
Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals. (1999) (75)
Fatal Respiratory Depression after Multiple Intravenous Morphine Injections (2006) (74)
Pure Enantiomers of 2‐Arylpropionic Acids: Tools in Pain Research and Improved Drugs in Rheumatology (1992) (73)
Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats (2002) (73)
Pharmacokinetics of meropenem in critically ill patients with acute renal failure undergoing continuous venovenous hemofiltration (1999) (72)
Pharmacokinetic modeling to predict morphine and morphine‐6‐glucuronide plasma concentrations in healthy young volunteers (2002) (72)
Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-Inflammatory Remedy Frankincense1 (2009) (71)
Inhibition of NF‐KB and AP‐1 activation by R‐ and S‐flurbiprofen 1, 2 (2001) (71)
Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells. (2004) (69)
Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases (1997) (69)
Celecoxib inhibits 5-lipoxygenase. (2008) (69)
Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2 (2011) (69)
Anti-inflammatory Role of Microsomal Prostaglandin E Synthase-1 in a Model of Neuroinflammation* (2010) (69)
Stereoselective high-performance liquid chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using a chiral alpha 1-acid glycoprotein column. (1990) (69)
Changes in the EEG power spectrum after midazolam anaesthesia combined with racemic or S – (+) ketamine (1994) (68)
Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man (1995) (68)
Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population. (2002) (67)
PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors. (2007) (66)
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain (2016) (66)
Additive Antinociceptive Effects of a Combination of Vitamin C and Vitamin E after Peripheral Nerve Injury (2011) (66)
Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection (2020) (66)
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 (2021) (66)
Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide. (2010) (66)
Interleukin-1β Induces Chronic Activation and de Novo Synthesis of Neutral Ceramidase in Renal Mesangial Cells* (2001) (65)
Lipoxin and resolvin biosynthesis is dependent on 5‐lipoxygenase activating protein (2015) (65)
Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing. (2005) (65)
Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses (2014) (64)
Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2 and Cytokines (2017) (64)
LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. (2006) (63)
Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models (2018) (63)
Respiratory and miotic effects of morphine in healthy volunteers when P‐glycoprotein is blocked by quinidine (2003) (63)
Drug Interactions with Patient-Controlled Analgesia (2002) (62)
Current evidence for a modulation of nociception by human genetic polymorphisms (2007) (62)
Inhibition of the Soluble Epoxide Hydrolase Promotes Albuminuria in Mice with Progressive Renal Disease (2010) (61)
Common non-epigenetic drugs as epigenetic modulators. (2013) (60)
LC-MS/MS-analysis of prostaglandin E2 and D2 in microdialysis samples of rats. (2005) (60)
Cysteine-Rich Protein 2, a Novel Downstream Effector of cGMP/cGMP-Dependent Protein Kinase I-Mediated Persistent Inflammatory Pain (2008) (60)
Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation (2000) (59)
The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS. (2013) (59)
Proteomics in Neuropathic Pain Research (2008) (58)
Stereoselective disposition of flurbiprofen in healthy subjects following administration of the single enantiomers. (1994) (58)
Drugging the pain epigenome (2017) (57)
Pharmacokinetics of imipenem-cilastatin in critically ill patients undergoing continuous venovenous hemofiltration (1997) (57)
Functional genomics of pain in analgesic drug development and therapy. (2013) (57)
Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats (2009) (57)
The anti-proliferative potency of celecoxib is not a class effect of coxibs. (2008) (56)
Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects. (1995) (56)
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions. (2007) (56)
Increased CNS uptake and enhanced antinociception of morphine‐6‐glucuronide in rats after inhibition of P‐glycoprotein (2002) (56)
Soluble Epoxide Hydrolase Deficiency Attenuates Neointima Formation in the Femoral Cuff Model of Hyperlipidemic Mice (2010) (55)
Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder. (2019) (55)
Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition (1991) (55)
Modulation of spinal nociceptive processing through the glutamate transporter GLT-1 (2002) (54)
Bupivacaine‐induced cellular entry of QX‐314 and its contribution to differential nerve block (2014) (54)
Effects of selective COX‐2 inhibition on prostanoids and platelet physiology in young healthy volunteers (2007) (54)
The pharmacological properties and clinical use of valdecoxib, a new cyclo‐oxygenase‐2‐selective inhibitor (2003) (54)
Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain (2003) (54)
High-performance liquid chromatographic determination of ibuprofen, its metabolites and enantiomers in biological fluids. (1989) (53)
TRP-channels as key integrators of lipid pathways in nociceptive neurons. (2014) (53)
SNO-ing at the Nociceptive Synapse? (2011) (53)
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis. (2017) (52)
MicroRNAs as new players in the pain game (2011) (52)
Pharmacogenetics of new analgesics (2011) (52)
Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2‐like polarization of tumor associated macrophages (2013) (51)
Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation (2011) (51)
A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection (2021) (51)
Pharmacokinetic modeling of M6G formation after oral administration of morphine in healthy volunteers. (1999) (51)
Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity (2014) (51)
Therapeutically relevant differences in the pharmacokinetical and pharmaceutical behavior of ibuprofen lysinate as compared to ibuprofen acid. (1989) (51)
Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils (2015) (51)
Ceramide Synthase 6 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis (2012) (51)
Olfactory and Trigeminal Event-Related Potentials in Migraine (2000) (51)
Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation. (1995) (50)
PAM mediates sustained inhibition of cAMP signaling by sphingosine‐1‐phosphate (2004) (50)
Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans (2014) (50)
Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state (1999) (50)
Cisplatin tumor concentrations after intra‐arterial cisplatin infusion or embolization in patients with oral cancer (2003) (50)
Stereoselective high-performance liquid chromatographic determination of flurbiprofen in human plasma. (1992) (49)
Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms. (2007) (49)
Population Pharmacokinetics of Fast Release Oral Diclofenac in Healthy Volunteers: Relation to Pharmacodynamics in an Experimental Pain Model (2004) (49)
Activation of c‐Jun‐N‐terminal‐kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers (2003) (49)
Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation. (2019) (49)
Slack Channels Expressed in Sensory Neurons Control Neuropathic Pain in Mice (2015) (49)
The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain. (2018) (48)
Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat (1998) (48)
The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia (2004) (48)
Is mPGES-1 a promising target for pain therapy? (2006) (48)
Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia (2001) (48)
Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB. (2007) (48)
5‐Lipoxygenase inhibitors induce potent anti‐proliferative and cytotoxic effects in human tumour cells independently of suppression of 5‐lipoxygenase activity (2010) (48)
Sphingosine 1-Phosphate Modulates Spinal Nociceptive Processing* (2008) (47)
Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation. (2003) (47)
Peripheral antihyperalgesic effect of morphine to heat, but not mechanical, stimulation in healthy volunteers after ultraviolet-B irradiation. (1999) (46)
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen. (2001) (46)
Time course of 8‐methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8‐methoxypsoralen (2002) (46)
Computerized survelliance of adverse drug reactions in hospital: pilot study. (1998) (46)
The Partial 5‐Hydroxytryptamine1A Receptor Agonist Buspirone does not Antagonize Morphine‐induced Respiratory Depression in Humans (2007) (46)
Small molecules with anti-inflammatory properties in clinical development. (2016) (46)
Inhibition of Noxious Stimulus‐Induced Spinal Prostaglandin E2 Release by Flurbiprofen Enantiomers (2000) (46)
Genome-Wide Transcriptional Profiling of Skin and Dorsal Root Ganglia after Ultraviolet-B-Induced Inflammation (2014) (46)
Nickel release, a possible indicator for the duration of antiplatelet treatment, from a nickel cardiac device in vivo: a study in patients with atrial septal defects implanted with an Amplatzer occluder. (2006) (45)
MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer (2015) (45)
Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment. (2006) (45)
Variability of inversion of (R)-flurbiprofen in different species. (1992) (45)
Inhibition of NF‐ κ B and AP‐1 activation by R‐ and S‐flurbiprofen 1 2 (2001) (45)
Is the formation of R-ibuprofenyl-adenylate the first stereoselective step of chiral inversion? (1994) (45)
Stereoselective high-performance liquid chromatographic determination of the enantiomers of ketamine and norketamine in plasma. (1991) (45)
The 5‐hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine‐induced respiratory depression (2005) (45)
Opposite Effects of Rofecoxib on Nuclear Factor-κB and Activating Protein-1 Activation (2003) (45)
Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1). (2012) (45)
Antinociceptive actions of R(-)-flurbiprofen--a non-cyclooxygenase inhibiting 2-arylpropionic acid--in rats. (1994) (45)
Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation. (2014) (44)
Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. (2007) (44)
Comparative proteomic analysis of the rat spinal cord in inflammatory and neuropathic pain models (2005) (43)
Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain (2017) (43)
Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis (2017) (43)
Effects of selective and unselective cyclooxygenase inhibitors on prostanoid release from various rat organs. (2000) (43)
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen (2021) (43)
Pattern of neuropathic pain induced by topical capsaicin application in healthy subjects (2015) (43)
CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity (2011) (43)
Determination of celecoxib in human plasma and rat microdialysis samples by liquid chromatography tandem mass spectrometry. (2001) (43)
The impact of endurance exercise on global and AMPK gene-specific DNA methylation. (2016) (43)
New Insights into the Site and Mode of Antinociceptive Action of Flurbiprofen Enantiomers (1996) (43)
Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation. (2003) (42)
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils (2015) (42)
The Consequence of Concomitantly Present Functional Genetic Variants for the Identification of Functional Genotype–Phenotype Associations in Pain (2009) (42)
The Ubiquitin Ligase MYCBP2 Regulates Transient Receptor Potential Vanilloid Receptor 1 (TRPV1) Internalization through Inhibition of p38 MAPK Signaling* (2010) (42)
Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A₄. (2013) (41)
Postoperative pain control following remifentanil‐based anaesthesia for major abdominal surgery (2000) (41)
R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice (2014) (41)
Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia (2009) (41)
Sniffing out pharmacology: interactions of drugs with human olfaction. (2012) (40)
Synthesis of Lipid Mediators during UVB-Induced Inflammatory Hyperalgesia in Rats and Mice (2013) (40)
Inhibitors of specific ceramide synthases. (2012) (40)
Drug Repurposing for the Development of Novel Analgesics. (2016) (40)
Antinociceptive activity of the S1P-receptor agonist FTY720 (2008) (39)
The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1) (2018) (38)
GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation. (2017) (38)
Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity (2017) (37)
Pharmacokinetics of morphine‐6‐glucuronide and its formation from morphine after intravenous administration (1998) (37)
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators. (2016) (37)
Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy (2018) (37)
Update on the pathobiology of neuropathic pain (2008) (37)
BKCa channels expressed in sensory neurons modulate inflammatory pain in mice (2014) (37)
Antinociceptive effects of morphine-6-glucuronide in homozygous MDR1a P-glycoprotein knockout and in wildtype mice in the hotplate test. (2000) (37)
The S1P2 receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes (2009) (37)
Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen (2020) (36)
Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells. (2014) (36)
UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells (2018) (36)
Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn (2008) (35)
Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury. (2013) (35)
Pharmacokinetics of S(+)- and R(−)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis (2006) (35)
Protein associated with Myc (PAM) is involved in spinal nociceptive processing (2004) (35)
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells (2018) (35)
The effect of the enantiomers of ibuprofen and flurbiprofen on the beta-oxidation of palmitate in the rat. (1992) (35)
Pharmacological differences between R(−)-and S(+)-ibuprofen (1989) (34)
The Protein Kinase IKKε Is a Potential Target for the Treatment of Inflammatory Hyperalgesia (2011) (34)
Prostaglandin D2 produced by hematopoietic prostaglandin D synthase contributes to LPS-induced fever. (2009) (34)
A critical appraisal of human genotyping for pain therapy. (2010) (34)
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders (2018) (34)
The Effects on Platelet Aggregation and Prostanoid Biosynthesis of two Parenteral Analgesics: Ketorolac Tromethamine and Dipyrone (1996) (34)
Plasma levels after peroral and topical ibuprofen and effects upon low pH‐induced cutaneous and muscle pain (2000) (34)
Dose-related effects of ibuprofen on pain-related potentials. (1994) (34)
The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity (2017) (33)
Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets (2013) (33)
Application of microdialysis to the pharmacokinetics of analgesics: problems with reduction of dialysis efficiency in vivo. (1994) (33)
Isolation and characterization of rat liver microsomal R-ibuprofenoyl-CoA synthetase. (1996) (33)
Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-κB. (2010) (33)
Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy: protection against anemia in patients with chronic hepatitis C (2011) (33)
Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences? (2006) (32)
Ceramide metabolism in mouse tissue. (2013) (32)
The cyclooxygenase 2 genetic variant −765G>C does not modulate the effects of celecoxib on prostaglandin E2 production (2006) (31)
Toponomics Analysis of Functional Interactions of the Ubiquitin Ligase PAM (Protein Associated with Myc) during Spinal Nociceptive Processing*S (2008) (31)
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far? (2022) (31)
Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. (2017) (31)
Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol. (2010) (31)
Naproxen concentrations in plasma and synovial fluid and effects on prostanoid concentrations. (1996) (31)
Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages (2014) (31)
Pharmacokinetics of ketoprofen enantiomers after different doses of the racemate. (1995) (31)
The glutamate transporter GLAST is involved in spinal nociceptive processing. (2006) (31)
Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis. (1993) (30)
Pharmacokinetic-Pharmacodynamic Modeling of the New Steroid Hypnotic Eltanolone in Healthy Volunteers (1996) (30)
High-Performance Liquid Chromatographic Analysis of Dipyrone Metabolites to Study Their Formation in Human Liver Microsomes (1996) (30)
Quantitation of endogenous nucleoside triphosphates and nucleosides in human cells by liquid chromatography tandem mass spectrometry (2015) (30)
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis. (2018) (30)
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy. (2018) (30)
Rapid genotyping for relevant CYP1A2 alleles by pyrosequencing (2005) (30)
Pharmacokinetics of ibuprofen enantiomers in dogs. (1991) (30)
Cross-sectional Assessment of the Consequences of a GTP Cyclohydrolase 1 Haplotype for Specialized Tertiary Outpatient Pain Care (2009) (30)
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML (2019) (30)
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology. (2018) (29)
AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin 4-polarized Human Macrophages* (2015) (29)
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice (2009) (29)
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice (2007) (29)
Dimethylcelecoxib inhibits prostaglandin E2 production. (2008) (29)
A rapid screening method for a single nucleotide polymorphism (SNP) in the human MOR gene. (2001) (29)
Low-dose drug combinations along molecular pathways could maximize therapeutic effectiveness while minimizing collateral adverse effects. (2011) (28)
Stereoselective determination of the enantiomers of methadone in plasma using high-performance liquid chromatography. (1992) (28)
Peripheral noxious stimulation releases spinal PGE2 during the first phase in the formalin assay of the rat. (1997) (28)
PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis. (2014) (28)
UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells (2020) (28)
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations (2010) (27)
Pharmacokinetic-pharmacodynamic relationships for analgesics. (1997) (27)
PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells (2016) (27)
Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis (2016) (27)
Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics. (2019) (27)
TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes (2015) (27)
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages (2018) (27)
2-Arylpropionyl-CoA epimerase: partial peptide sequences and tissue localization. (1995) (27)
Highly sensitive determination of HCV protease inhibitors boceprevir (SCH 503034) and telaprevir (VX 950) in human plasma by LC-MS/MS. (2009) (26)
An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes (2010) (26)
Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury. (2012) (26)
A pirinixic acid derivative (LP105) inhibits murine 5‐lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm (2011) (26)
Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53. (2005) (26)
Consequences of a Human TRPA1 Genetic Variant on the Perception of Nociceptive and Olfactory Stimuli (2014) (26)
Neutrophils mediate edema formation but not mechanical allodynia during zymosan‐induced inflammation (2014) (26)
Interleukin-1beta induces chronic activation and de novo synthesis of neutral ceramidase in renal mesangial cells. (2001) (26)
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase (2019) (25)
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (2019) (25)
Lack of Microsomal Prostaglandin E2 Synthase-1 in Bone Marrow–Derived Myeloid Cells Impairs Left Ventricular Function and Increases Mortality After Acute Myocardial Infarction (2012) (25)
No Contribution of Morphine‐6-Glucuronide to Clinical Morphine Effects After Short‐Term Administration (1998) (25)
Stereoselective pharmacokinetics of methadone in beagle dogs. (1994) (25)
Association of Saquinavir Plasma Concentrations with Side Effects but Not with Antiretroviral Outcome in Patients Infected with Protease Inhibitor-Susceptible Human Immunodeficiency Virus Type 1 (2007) (25)
Screening for IL28B gene variants identifies predictors of hepatitis C therapy success (2010) (24)
Simultaneous and sensitive LC–MS/MS determination of tetrahydrocannabinol and metabolites in human plasma (2013) (24)
Differential effects of dipyrone, ibuprofen, and paracetamol on experimentally induced pain in man (2005) (24)
The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated (2019) (24)
The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE−/− mice (2007) (24)
Expression of rat liver long-chain acyl-CoA synthetase and characterization of its role in the metabolism of R-ibuprofen and other fatty acid-like xenobiotics. (2001) (24)
Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib. (2006) (24)
p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells. (2008) (24)
Comprehensive mu-opioid-receptor genotyping by pyrosequencing. (2004) (24)
Effects of azapropazone on pain-related brain activity in human subjects. (1995) (23)
Biphasic Regulation of HMG-CoA Reductase Expression and Activity during Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses* (2008) (23)
Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing. (2009) (23)
Is morphine-3-glucuronide of therapeutic relevance? (2005) (23)
Pyrosequencing-based screening for genetic polymorphisms in cytochrome P450 2B6 of potential clinical relevance. (2006) (23)
An in vitro test system for compounds that modulate human inflammatory macrophage polarization (2018) (23)
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death (2020) (23)
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1 (2018) (23)
Computerized surveillance of adverse drug reactions in hospital: pilot study (1998) (23)
A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages (2018) (23)
Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity. (2013) (23)
The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue (2018) (23)
Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues. (2016) (22)
Keratinocyte-Derived Vascular Endothelial Growth Factor Biosynthesis Represents a Pleiotropic Side Effect of Peroxisome Proliferator-Activated Receptor-γ Agonist Troglitazone but Not Rosiglitazone and Involves Activation of p38 Mitogen-Activated Protein Kinase: Implications for Diabetes-Impaired Ski (2008) (22)
Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity (2018) (22)
Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling. (2016) (22)
Exogenous Delta9-Tetrahydrocannabinol Influences Circulating Endogenous Cannabinoids in Humans (2013) (22)
UGCG influences glutamine metabolism of breast cancer cells (2019) (22)
Effects of the opioid remifentanil on olfactory function in healthy volunteers. (2001) (22)
Potential biomarkers for persistent and neuropathic pain therapy. (2019) (21)
Comparison of the antinociception produced by two oral formulations of ibuprofen: ibuprofen effervescent vs ibuprofen tablets (1997) (21)
Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors (2018) (21)
Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome. (2003) (21)
Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord (2005) (21)
Inhibitor κB Kinase β Deficiency in Primary Nociceptive Neurons Increases TRP Channel Sensitivity (2009) (21)
Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function (2009) (21)
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen. (2001) (20)
Nimodipine plasma concentration and retinal blood flow in healthy subjects. (2006) (20)
Machine-Learned Data Structures of Lipid Marker Serum Concentrations in Multiple Sclerosis Patients Differ from Those in Healthy Subjects (2017) (20)
S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population (2016) (20)
The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage (2018) (20)
High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease (2020) (20)
Downregulation of Cytosolic Prostaglandin E2 Synthase Results in Decreased Nociceptive Behavior in Rats (2005) (20)
Group V Phospholipase A2 in Bone Marrow-derived Myeloid Cells and Bronchial Epithelial Cells Promotes Bacterial Clearance after Escherichia coli Pneumonia* (2011) (20)
Cellular membranes function as a storage compartment for celecoxib (2009) (20)
Simultaneous screening for three mutations in the ABCB1 gene. (2003) (20)
Implementation of lipidomics in clinical routine: Can fluoride/citrate blood sampling tubes improve preanalytical stability? (2020) (20)
Microsomal Prostaglandin E 2 Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction (2008) (20)
Improved technique for cannulation of the murine thoracic duct: a valuable tool for the dissection of immune responses. (1997) (20)
Proteomics and NF-κB: an update (2013) (19)
Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach (2020) (19)
[Therapy with opioids in liver or renal failure]. (1999) (19)
Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain (2020) (19)
Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury. (2014) (19)
Pharmacokinetics of ketamine enantiomers. (1995) (19)
Dimethylcelecoxib induces an inhibitory complex consisting of HDAC1/NF-κB(p65)RelA leading to transcriptional downregulation of mPGES-1 and EGR1. (2012) (19)
Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization (2019) (19)
Probenecid Interacts with the Pharmacokinetics of Morphine-6-glucuronide in Humans (2004) (19)
High sensitive determination of sufentanil in human plasma of parturients and neonates following patient-controlled epidural analgesia (PCEA). (2006) (19)
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent. (2014) (18)
Pharmacokinetic Dynamic Modeling Of The New Intravenous Anesthetic Eltanolone (1994) (18)
The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs. (2013) (18)
Inhibition of HDAC Enzymes Contributes to Differential Expression of Pro-Inflammatory Proteins in the TLR-4 Signaling Cascade (2020) (18)
Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ (2019) (18)
The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons (2017) (18)
Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. (2007) (18)
Localization of an endocannabinoid system in the hypophysial pars tuberalis and pars distalis of man (2010) (17)
Activation of AMPK and its Impact on Exercise Capacity (2015) (17)
Effects on platelet functions and pharmacokinetics of azapropazone and ketorolac tromethamine given as single parenteral doses. (1994) (17)
CXCL16/CXCR6-mediated adhesion of human peripheral blood mononuclear cells to inflamed endothelium. (2017) (17)
Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors (2015) (17)
Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase (2016) (17)
Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1. (2013) (17)
Comparison of Tissue Concentrations After Intramuscular and Topical Administration of Ketoprofen (2001) (17)
Effect of clofibrate on the chiral inversion of ibuprofen in healthy volunteers (1998) (16)
LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma. (2012) (16)
AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids (2017) (16)
Machine-learned analysis of the association of next-generation sequencing–based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin (2018) (16)
Congenital taurine deficiency in mice is associated with reduced sensitivity to nociceptive chemical stimulation (2014) (16)
Stereoselectivity of biliary excretion of 2-arylpropionates in rats. (1993) (16)
Rapid identification of three functionally relevant polymorphisms in the OATP1B1 transporter gene using Pyrosequencing. (2006) (16)
Topical 5‐fluorouracil in Darier disease (2008) (16)
Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B–induced local skin hypersensitization in healthy subjects: a machine-learned analysis (2017) (15)
Simultaneous fitting of R- and S-ibuprofen plasma concentrations after oral administration of the racemate. (2001) (15)
A new reliable chemiluminescence immunoassay (CLIA) for prostaglandin E2 using enhanced luminol as substrate. (1996) (15)
Bedside‐to‐Bench Pharmacology: A Complementary Concept to Translational Pharmacology (2010) (15)
Natural antiviral compound silvestrol modulates human monocyte‐derived macrophages and dendritic cells (2020) (15)
Single-step identification of all length polymorphisms in the UGT1A1 gene promoter. (2004) (15)
Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses. (2018) (15)
Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation. (2012) (15)
The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats (2002) (15)
Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells. Relationship to in vivo metabolism. (1992) (15)
Analysis of NF-κB signaling pathways by proteomic approaches (2010) (15)
Opioid receptor agonist potencies of morphine and morphine-6-glucuronide in the guinea-pig ileum. (1994) (15)
The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells (2020) (15)
Michael acceptor containing drugs are a novel class of 5‐lipoxygenase inhibitor targeting the surface cysteines C416 and C418 (2017) (15)
Influence of glycosphingolipids on cancer cell energy metabolism. (2020) (14)
Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice (2014) (14)
Nano-LC-MS/MS for the quantitation of prostanoids in immune cells (2014) (14)
Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase. (1998) (14)
Site-Specific and Time-Dependent Activation of the Endocannabinoid System after Transection of Long-Range Projections (2012) (14)
Disagreement between two common biomarkers of global DNA methylation (2016) (14)
Single Dose Pharmacokinetics of Different Formulations of Ibuprofen and Aspirin (1993) (14)
The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain (2015) (14)
AMP-activated protein kinase is activated by non-steroidal anti-inflammatory drugs. (2015) (14)
Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry. (2018) (13)
LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR. (2014) (13)
Intrinsic Up-Regulation of 2-AG Favors an Area Specific Neuronal Survival in Different In Vitro Models of Neuronal Damage (2012) (13)
Nerve Injury Evoked Loss of Latexin Expression in Spinal Cord Neurons Contributes to the Development of Neuropathic Pain (2011) (13)
Cerebrospinal fluid prostaglandins after systemic dipyrone intake (1998) (13)
Bovine embryo elongation is altered due to maternal fatty acid supplementation (2018) (13)
Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators. (2014) (13)
The Biliary Elimination and Enterohepatic Circulation of Ibuprofen in Rats (2004) (13)
Single and combined IL28B, ITPA and SLC28A3 host genetic markers modulating response to anti-hepatitis C therapy. (2011) (13)
Stereospecific determination of tiaprofenic acid in plasma: problems with drug degradation. (1996) (13)
Pharmacoepigenetics of the role of DNA methylation in μ-opioid receptor expression in different human brain regions. (2016) (13)
Drug Acetylation in Liver Disease (1998) (13)
Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo (2015) (12)
Nano-LC-MS/MS for the quantitation of ceramides in mice cerebrospinal fluid using minimal sample volume. (2013) (12)
Disposition and effects of flurbiprofen enantiomers in human serum and blister fluid. (2003) (12)
GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells. (2019) (12)
Determination of 8-methoxypsoralen in human plasma, and microdialysates using liquid chromatography-tandem mass spectrometry. (2003) (12)
The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model. (2016) (12)
Quantitation of ribavirin in human plasma and red blood cells using LC-MS/MS. (2014) (12)
Is the inversion from R- to S-ketoprofen concentration dependent? Investigations in rats in vivo and in vitro. (1994) (12)
Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP‐001 (2019) (12)
Phosphodiesterase 2A Localized in the Spinal Cord Contributes to Inflammatory Pain Processing (2014) (12)
The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception. (2007) (12)
The effects of S- and R-flurbiprofen on the inflammation-evoked intraspinal release of immunoreactive substance P—a study with antibody microprobes (1998) (11)
Metabolic Chiral Inversion of 2-Arylpropionic Acids (2003) (11)
Stereoselective disposition of tiaprofenic acid enantiomers in rats. (1999) (11)
Prostaglandin D(2) sustains the pyrogenic effect of prostaglandin E(2). (2009) (11)
In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse (2015) (11)
The real gordian knot: racemic mixtures versus pure enantiomers. (1998) (11)
CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages. (2017) (11)
Proton-Sensing GPCRs in Health and Disease (2021) (11)
5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift (2019) (11)
Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model (2016) (10)
The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors (2012) (10)
Prostacyclin Regulates Spinal Nociceptive Processing through Cyclic Adenosine Monophosphate–induced Translocation of Glutamate Receptors (2014) (10)
Genetic polymorphism of the type A human natriuretic peptide receptor (NPR‐A) gene contributes to the interindividual variability in the BNP system (2008) (10)
Rapid Determination of Methadone in Plasma, Cerebrospinal Fluid, and Urine by Gas Chromatography and Its Application to Routine Drug Monitoring (1993) (10)
Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells. (2020) (10)
Induction of apoptosis in human prostate stromal cells by 4-hydroxytamoxifen: an alternative therapy for benign prostate hyperplasia (2004) (10)
High-performance liquid chromatographic determination of pentazocine in plasma. (1990) (10)
Pharmacological plasticity—How do you hit a moving target? (2019) (9)
The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain (2020) (9)
Pharmacological and histopathological characterization of a hyperalgesia model induced by freeze lesion (2007) (9)
Effect of clofibrate on the chiral disposition of ibuprofen in rats. (1998) (9)
R-flurbiprofen: isomeric ballast or active entity of the racemic compound? (1993) (9)
Cav1.3 calcium channels are full-range linear amplifiers of firing frequencies in lateral DA SN neurons (2022) (9)
Omega-3 and -6 fatty acid plasma levels are not associated with liver cirrhosis-associated systemic inflammation (2019) (8)
EEG analysis and pharmacodynamic modelling after intravenous bolus injection of eltanolone (pregnanolone). (1995) (8)
Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice (2019) (8)
Lipoxin A₄: problems with its determination using reversed phase chromatography-tandem mass spectrometry and confirmation with chiral chromatography. (2014) (8)
Monoclonal Antibodies in Preclinical EAE Models of Multiple Sclerosis: A Systematic Review (2017) (8)
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase. (2020) (8)
Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab (2019) (8)
Benefit-Risk Assessment of Rofecoxib in the Treatment of Osteoarthritis (2004) (8)
The pharmacogenetic background of hepatitis C treatment. (2012) (8)
Necessity and Risks of Arterial Blood Sampling in Healthy Volunteer Studies (2012) (8)
S-Ibuprofen versus ibuprofen-racemate (2004) (8)
SAMHD 1 is a biomarker for cytarabine response and a therapeutic target 1 in acute myeloid leukemia 2 (8)
Characterization of the molecular mechanism of 5‐lipoxygenase inhibition by 2‐aminothiazoles (2017) (8)
High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion (2016) (8)
Spatial distribution of 8-methoxypsoralen penetration into human skin after systemic or topical administration. (2002) (8)
Exploring CYP2J2: lipid mediators, inhibitors and therapeutic implications. (2020) (7)
A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization (2021) (7)
The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP) (2020) (7)
A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects (2016) (7)
Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation. (2019) (7)
Alpha‐methylacyl‐CoA racemase deletion has mutually counteracting effects on T‐cell responses, associated with unchanged course of EAE (2016) (7)
Oxidized linoleic acid metabolites maintain mechanical and thermal hypersensitivity during sub-chronic inflammatory pain. (2022) (7)
Higher pain scores, similar opioid doses and side effects associated with antipyretic analgesics in specialised tertiary pain care (2010) (7)
The effect of tenoxicam on tolbutamide pharmacokinetics and glucose concentrations in healthy volunteers. (1995) (7)
Rapid screening for potentially relevant polymorphisms in the human fatty acid amide hydrolase gene using Pyrosequencing. (2007) (7)
Rab7—a novel redox target that modulates inflammatory pain processing (2017) (7)
Verapamil decreases glucuronidase activity in the gut. (2002) (7)
Rab27a Contributes to the Processing of Inflammatory Pain in Mice (2020) (7)
Intravenous morphine-6-glucuronide (M6G) is devoid of analgesic activity in man. (1997) (7)
AMP-activated kinase and the endogenous endocannabinoid system might contribute to antinociceptive effects of prolonged moderate caloric restriction in mice (2017) (7)
Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain (2013) (6)
The histone demethylase Jarid1b mediates angiotensin II‐induced endothelial dysfunction by controlling the 3′UTR of soluble epoxide hydrolase (2019) (6)
Comparative clinical effects of hydromorphone and morphine: a meta-analysis. (2012) (6)
Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice (2015) (6)
A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients With Dementia (2019) (6)
Promoter Activation in Δ hfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (2019) (6)
Oxaliplatin Causes Transient Changes in TRPM8 Channel Activity (2021) (6)
Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model (2021) (6)
Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression (2018) (6)
Determination of neopterin and biopterin by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in rat and human plasma, cell extracts and tissue homogenates (2006) (6)
Lecanoric acid mediates anti-proliferative effects by an M phase arrest in colon cancer cells. (2022) (6)
Rhythmic control of endocannabinoids in the rat pineal gland (2015) (6)
Programming of a flexible computer simulation to visualize pharmacokinetic-pharmacodynamic models. (2004) (6)
Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer’s Disease (2020) (5)
[Selective cyclooxygenase-2 inhibitor. Pharmacology and state of knowledge following commercial availability]. (2001) (5)
Cleavage of SNAP‐25 ameliorates cancer pain in a mouse model of melanoma (2017) (5)
Synthesis and Activity of Fluorinated Derivatives of Sulindac Sulphide and Sulindac Sulphone (2000) (5)
1 THE UBIQUITIN LIGASE MYCBP 2 REGULATES TRANSIENT RECEPTOR POTENTIAL VANILLOID RECEPTOR 1 ( TRPV 1 )-INTERNALIZATION THROUGH INHIBITION OF p 38 MAPK SIGNALING (2010) (5)
Computer-Aided Selective Optimization of Side Activities of Talinolol. (2019) (5)
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer (2021) (5)
12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation. (2020) (5)
Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2 (2012) (5)
Tumors Provoke Inflammation and Perineural Microlesions at Adjacent Peripheral Nerves (2020) (5)
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells (2021) (5)
Sphingolipid and Endocannabinoid Profiles in Adult Attention Deficit Hyperactivity Disorder (2021) (5)
R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4 (2016) (5)
Mast cell tetrahydrobiopterin contributes to itch in mice (2018) (5)
4 Ds in health research—working together toward rapid precision medicine (2019) (5)
p 53 Phosphorylation with Morphine in Adenocarcinoma Cells : Involvement of Cell Cycle Block and Apoptosis 1 G Protein-independent G Updated (2003) (5)
Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport (2022) (4)
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages (2021) (4)
Novel Approaches to Persistent Pain Therapy. (2019) (4)
Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels—An Exploratory In Vivo Kinetic Study (2021) (4)
Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. (2020) (4)
Identification of DNA-protein complexes using an improved, combined western blotting-electrophoretic mobility shift assay (WEMSA) with a fluorescence imaging system. (2012) (4)
Metabolic chiral inversion of 2-arylpropionates in different tumor cell lines. (1993) (4)
SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain (2022) (4)
Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia (2017) (4)
Inhibition of NF − κ B and AP-1 activation by Rand S-flurbiprofen (2000) (4)
Drug Repurposing to Target Neuroinflammation and Sensory Neuron-Dependent Pain (2022) (4)
Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression (2021) (4)
Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300 (2017) (4)
Absorption and Distribution of Ibuprofen and Acetylsalicylic Acid Formulations (1994) (4)
Lipidomic analysis of local inflammation models shows a specific systemic acute phase response to lipopolysaccharides. (2020) (4)
Transfer of different nonsteroidal antiinflammatory drugs via the lymphatic system in the rat. (1996) (4)
Pre-analytical challenges for the quantification of endocannabinoids in human serum. (2022) (3)
Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis (2020) (3)
Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia (2013) (3)
Telaprevir drug monitoring during antiviral therapy of hepatitis C graft infection after liver transplantation (2015) (3)
Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1 (2020) (3)
Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis (2022) (3)
The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1) (2018) (3)
Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice (2022) (3)
Hyperhomocysteinemia: Metabolic Role and Animal Studies with a Focus on Cognitive Performance and Decline—A Review (2021) (3)
A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects (2020) (3)
A validated LC-MS/MS method for the determination of homocysteic acid in biological samples. (2019) (3)
Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains. (2018) (3)
Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells (2021) (3)
Prodromal sensory neuropathy in Pink1−/−SNCAA53T double mutant Parkinson mice (2021) (3)
Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy. (2017) (2)
Comparison of two screening methods for in-house genotyping in clinical pharmacology units. (2005) (2)
This information is current as Anti-Inflammatory Remedy Frankincense theFunctional Target of Boswellic Acids from Identification of Human Cathepsin G As a (2009) (2)
Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes (2020) (2)
Encyclopedia of pain, vol. 1-3 (2007) (2)
Effects of sodium salicylate on elimination kinetics of indomethacin and bile production in dogs. (1990) (2)
In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o (2020) (2)
Biotechnological approach towards a highly efficient production of natural prostaglandins (2014) (2)
[Are polymorphisms in the mu-opioid receptor important for opioid therapy?]. (2005) (2)
Contribution of cyclooxygenase-1-dependent prostacyclin synthesis to bradykinin-induced dermal extravasation. (2022) (2)
[Drug interactions in pain therapy]. (2015) (2)
NADPH Oxidase 4 essentially contributes to nociceptive processing in neuropathic pain states (2012) (2)
Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis (2019) (2)
The COVID-19 PHARMACOME: Rational Selection of Drug Repurposing Candidates from Multimodal Knowledge Harmonization (2020) (2)
Increased Fat Taste Preference in Progranulin-Deficient Mice (2021) (2)
TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes (2015) (2)
Similar Maximum Systemic but not Local Cyclooxygenase-2 Inhibition by 50 mg Lumiracoxib and 90 mg Etoricoxib: A Randomized Controlled Trial in Healthy Subjects (2014) (2)
Misestimating the role of an active metabolite when modeling the effects after administration of the parent compound only (2006) (2)
AGMO Inhibitor Reduces 3T3-L1 Adipogenesis (2021) (2)
Post-mortem changes of prostanoid concentrations in tissues of mice: impact of fast cervical dislocation and dissection delay. (2022) (2)
Neither cimetidine nor probenecid affect the pharmacokinetics of tenoxicam in normal volunteers. (1994) (2)
Cytochrome P450 Epoxygenase Dependence of Opioid Analgesia: Fluconazole Does Not Interfere With Remifentanil‐Mediated Analgesia in Human Subjects (2014) (2)
GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression. (2022) (2)
Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation. (2018) (2)
Pre-analytical sample handling standardization for reliable measurement of metabolites and lipids in LC-MS-based clinical research (2023) (1)
[Pharmacological aspects of pain research in Germany]. (2015) (1)
Correction: In the article Alterations in the Hippocampal Endocannabinoid System in Diet-Induced Obese Mice by Federico Massa, Giacomo Mancini, Helmut Schmidt, Frauke (2010) (1)
The FKBP51 Inhibitor SAFit2 Restores the Pain-Relieving C16 Dihydroceramide after Nerve Injury (2022) (1)
Lymph distribution of different non-steroidal anti-inflammatory drugs assessed by microsurgical cannulation of the thoracic duct in rat. (1996) (1)
[Generating knowledge from complex data sets in human experimental pain research]. (2019) (1)
Trehalose Reduces Nerve Injury Induced Nociception in Mice but Negatively Affects Alertness (2021) (1)
Treatment with FTY-720 reverses social recognition deficits without affecting clinical scores or impaired motor performance in EAE in SJL mice (2014) (1)
A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection (2021) (1)
HyperalgesiaTarget for the Treatment of Inflammatory Is a Potential e The Protein Kinase IKK (2011) (1)
Phosphatidylethanolamine Deficiency and Triglyceride Overload in Perilesional Cortex Contribute to Non-Goal-Directed Hyperactivity after Traumatic Brain Injury in Mice (2022) (1)
Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers (2020) (1)
Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity (2017) (1)
PHARMACOKINETICS AND DYNAMICS OF KETAMINE ENANTIOMERS USING A STEREOSELECTIVE ANALYTICAL METHOD (1992) (1)
Astrocytic ATX fuels synaptic phospholipid signaling involved in psychiatric disorders (2018) (1)
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells (2021) (1)
The immunomodulatory potential of the arylmethylaminosteroid sc1o (2020) (1)
cGMP-dependent signaling pathways in spinal pain processing (2009) (1)
A randomized double-blind study in patients with rheumatoid arthritis (1991) (1)
Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice (2020) (1)
[A microsurgical approach to drainage of the thoracic duct in the rat]. (1996) (1)
Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes (2019) (1)
Use of protein associated with mye (pam) to treat pain (2004) (0)
Early prodromal sensory neuropathy in Pink1-SNCA double mutant Parkinson mice (2020) (0)
Rücktitelbild: Promoter Activation in Δ hfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (Angew. Chem. 52/2019) (2019) (0)
Use of the R-arylpropionic acids for the preparation of medicaments for the treatment of disorders of the rheumatic nature (2001) (0)
Back Cover: Promoter Activation in Δ hfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (Angew. Chem. Int. Ed. 52/2019) (2019) (0)
SAMHD1 Bound to Gemcitabine-TP in the Catalytic Pocket (2018) (0)
Eosinophil‐derived IL‐4 is necessary to establish the inflammatory structure in innate inflammation (2022) (0)
P075 Inflammation-induced cancer vs. cancer-induced inflammation is dependent on S1P lyase (2018) (0)
Abstract 1926: Elevated Serum Levels of Platelet Reactivity Enhancing Oxidized Choline Glycerophospholipids in Patients with Acute Coronary Syndromes and Reduction by High Dose Statin Therapy (2008) (0)
Editorial Board (2009) (0)
Effect of Flurbiprofen (FLU) Enantiomers on Prostaglandin E2 (PGE2) and Substance p (SP) Levels in Human Suction Blister (1996) (0)
Effects ofazapropazone onpain-related brain activity in humansubjects (1995) (0)
Exacerbated Experimental Autoimmune Encephalomyelitis in Ceramide Synthase 6 Knockout Mice is Associated with Enhanced Activation/Migration of Neutrophils (P2.195) (2015) (0)
Use of calpain for the identification of pain-compounds (2003) (0)
Using a granulin or granulin-like compound for the treatment or prophylaxis of chronic pain (2007) (0)
Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis (2017) (0)
2-arylpropionic acid compositions and methods for their preparation (1992) (0)
Role of telaprevir plasma levels for predicting response to antiviral therapy in patients with hepatitis C virus genotype 1 infection (2014) (0)
Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain (2013) (0)
P71 Opioid receptor potency of morphine-3-glucuronide in the guinea-pig ileum (1994) (0)
Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy (2018) (0)
Editorial Board (2009) (0)
Anti-Inflammatory Remedy Frankincense the Functional Target of Boswellic Acids from Identification of Human Cathepsin G As a (2009) (0)
[Pain management in general practice. Therapy with nonsteroidal anti-inflammatory drugs]. (2000) (0)
Drug as well as their preparation and their use in combating pain and / or inflammation and / or fever in animals and humans (1990) (0)
Drug and its preparation and use in the treatment of painful neuropathies. (2008) (0)
2-aryl-propionic acid-preparations and process for their manufacture (1993) (0)
FC58 R-enantiomers of 2-arylpropionic acids: Isomeric ballast or active entity of the commonly used racemate? (1994) (0)
Regulatory T Cells + CD 25 + Activity of CD 4 Mice by Directly Affecting the Functional FTY 720 Ameliorates Th 1-Mediated Colitis in Geisslinger (2013) (0)
The role of cGMP and PKG-I in spinal nociceptive processing (2005) (0)
Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia (2013) (0)
Lack of analgesic effects of morphine‐6‐glucuronide after I.V.‐administration in man (1996) (0)
The Roles of Long-Term Hyperhomocysteinemia and Micronutrient Supplementation in the AppNL–G–F Model of Alzheimer’s Disease (2022) (0)
Correction: Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders (2019) (0)
An objective, automated and robust scoring using fluorescence optical imaging to evaluate changes in micro-vascularisation indicating early arthritis (2022) (0)
Drug, and the preparation and use thereof in the treatment of painful neuropathies (2008) (0)
Stereoselective disposition of ibuprofen enantiomers in man. Commentary. Author's reply (2004) (0)
USE OF I kappa B KINASE INHIBITORS IN PAIN (2003) (0)
[Advantages and disadvantages of anesthesia induction with midazolam and S-ketamine in comparison with barbiturates]. (1993) (0)
42 SPHINGOSINE 1-PHOSPHATE: REGULATOR OF INFLAMMATION AND PAIN (2011) (0)
Effects of Different Storage Conditions on Lipid Stability in Mice Tissue Homogenates (2023) (0)
Use of 2-amino-1,3-propandiolderivaten for preparing a medicament for the treatment of certain pain (2004) (0)
1157 NUCLEOSIDE TRANSPORTER SLC28A2/3 AND SLC29A1/2 GENETICS: PROTECTION AGAINST ANAEMIA IN CHRONIC HEPATITIS C PATIENTS RECEIVING RIBAVIRIN (2011) (0)
Supplemental Information Synaptic bioactive phospholipid signaling : A new target for treating psychiatric disorders Running title : Bioactive lipids in psychiatric disorders (2018) (0)
Intrinsically Bursting Neurons Postexcitatory Hyperpolarization in Neocortical Current Contributes to (2015) (0)
Rethinking the use of NSAIDs in early acute pain. (2023) (0)
Role of alpha-metylacyl-CoA racemase in immune cells during the development of experimental autoimmune encephalomyelitis (2014) (0)
Cysteine-rich protein 2 is a downstream effector of cGMP-dependent protein kinase I in nociception (2007) (0)
UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells (2018) (0)
[Clinical pharmacology of the selective COX-2 inhibitors]. (2003) (0)
Blood pressure and albuminuria. (2013) (0)
Do maternal dietary omega-3 or omega-6 fatty acids affect embryo-maternal communication and preimplantation embryo development in Angus heifers? (2017) (0)
Activation of c-Jun-N-terminal-kinase by R- and S-flurbiprofen results in cell cycle arrest in human colon carcinoma cells (2002) (0)
[Ketamine--unwanted effects and possible complications]. (1993) (0)
Biotechnological approach towards a highly efficient production of natural prostaglandins (2014) (0)
[Current post-marketing information. Effects and adverse effects of celecoxib]. (2002) (0)
Variability inthestereoselective disposition ofibuprofen in patients withrheumatoid arthritis (1993) (0)
UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells (2020) (0)
The suction blister as an in vivo model of inflammation Interblister variability and preliminary studies of the disposition of methotrexate (1997) (0)
CRP4 is a downstream effector of cGKI in nociceptive processing (2014) (0)
Similar Maximum Systemic but not Local Cyclooxygenase-2 Inhibition by 50 mg Lumiracoxib and 90 mg Etoricoxib: A Randomized Controlled Trial in Healthy Subjects (2014) (0)
SAMHD1 Bound to Cytarabine-TP in the Catalytic Pocket (2018) (0)
Release of 5,6-Epoxyeicosatrienoic acid (5,6-EET) upon neuronal activity induces TRPA1-dependent mechanical pain hypersensitivity (2012) (0)
The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity (2017) (0)
UGCG influences glutamine metabolism of breast cancer cells (2019) (0)
Mandarin Translations (2011) (0)
P.759 Impact of hyperhomocysteinemia and different dietary interventions on cognitive performance in a knock-in mouse model for Alzheimer's disease (2020) (0)
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis (2019) (0)
Use of drugs with mu-opioid receptor agonist action as a combination drug for cancer treatment (2001) (0)
Population Pharmacokinetics of Fast release oral NSAIDs than with common tablet formulations. Release Oral Diclofenac in Healthy Fast and "normal" release formulations differ by their pharma- (2000) (0)
Preparation of flurbiprofen-containing drugs to combat pain and / or inflammation in animals and humans (1993) (0)
[An experimental model of the microsurgical cannulation of the thoracic duct in the rat]. (1996) (0)
Lack of CerS2 Suppresses the Development of Experimental Autoimmune Encephalomyelitis by Impairing the Migratory Potential of Neutrophils (P5.343) (2016) (0)
SAMHD1 Bound to Vidarabine-TP in the Catalytic Pocket (2018) (0)
Assessment of the effects of P-glycoprotein inhibition on the blood-brain barrier distribution by in vivo microdialysis in rats (2001) (0)
[Possibilities and limitations of intravenous anesthesia]. (1991) (0)
SAMHD1 Bound to Fludarabine-TP in the Catalytic Pocket (2018) (0)
2-Arylpropionsyrepræparater and process for production thereof (1993) (0)
Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes (2019) (0)
Ether lipid and sphingolipid expression patterns are G-protein coupled estrogen receptor 1-dependently altered in breast cancer cells (2020) (0)
153 TELAPREVIR BLOOD LEVELS ARE UNALTERED IN PATIENTS WITH CICLOSPORIN AND TACROLIMUS BASED IMMUNOSUPPRESSION AFTER ORTHOTOPIC LIVER TRANSPLANTATION (2013) (0)
[Fundamental principles of clinical trials]. (2005) (0)
813 TELAPREVIR SERUM LEVELS DURING TREATMENT FOR HCV GT1 INFECTION ARE ASSOCIATED WITH EXTENDED RAPID VIROLOGIC RESPONSE BUT DO NOT AFFECT HEMOGLOBIN DECLINE (2013) (0)
Disagreement between two common biomarkers of global DNA methylation (2016) (0)
Differential pharmacokinetics and effects of S(+)- and R(-) ibuprofen in volunteers and patients (1990) (0)
[Pain models and clinical pain research are not contradictory]. (2020) (0)
SAMHD1 HD domain bound to decitabine triphosphate (2019) (0)
SAMHD1 without Catalytic Nucleotides (2018) (0)
A mathematical model to predict plasma concentrations of morphine and its active metabolite morphine-6-glucuronide in healthy young persons (2002) (0)
P.354 Elevated ceramide plasma level in major depression and bipolar disorder indicate an increased risk for metabolic dysregulation (2019) (0)
Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression (2018) (0)
USE OF ACTIVE INGREDIENTS WITH õ-opioid receptor agonist action AND OPIOID RECEPTOR ANTAGONISTIC EFFECT AS COMBINATION DRUGS FOR CANCER TREATMENT (2002) (0)
Author response for "Prodromal sensory neuropathy in Pink1(-/-)SNCA(A53T) double mutant Parkinson mice" (2021) (0)
Use of R-arylpropionic acids for the preparation of medicaments for the treatment of diseases in humans and animals, which can be therapeutically affected by the inhibition of the activation of NF-kB (1999) (0)
Dietary rumen-protected omega-3 and omega-6 fatty acids impact differently on histotroph and elongation of preimplantation embryos in heifers (2016) (0)
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells (2018) (0)
Prognostic relevance of alterations in sphingolipid metabolism in breast cancer (2008) (0)
SAMHD1 Bound to Cladribine-TP in the Catalytic Pocket and Allosteric Pocket (2018) (0)
Effects of dietary rumen-protected omega-3-fatty acids on early embryonic development in heifers (2015) (0)
Abstract 5299: Release of Sphingosine-1-Phosphate From Platelets Requires Thromboxane Synthesis and Thromboxane Receptor Activation (2009) (0)
SAMHD1 Bound to Clofarabine-TP in the Catalytic Pocket and Allosteric Pocket (2018) (0)
Pharmacokinetics ofketoprofen enantiomers after different doses oftheracemate (1995) (0)
A medicament containing Ibuprofenthioester as inhibitors of NF-kappaB-dependent formation of mediators of inflammation and pain (1997) (0)

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