Gerd Multhaup

Q: What Schools Are Affiliated With Gerd Multhaup

Gerd Multhaup is affiliated with the following schools: McGill University, University of Cologne, University of Konstanz, University of Melbourne, University of California, San Diego, Free University of Berlin, University of Hamburg, University of Bonn, Heidelberg University

Gerd Multhaup's AcademicInfluence.com Rankings

Gerd Multhaup

Chemistry

#3290

World Rank

#4296

Historical Rank

chemistry Degrees

Gerd Multhaup

Biology

#9262

World Rank

#12447

Historical Rank

Molecular Biology

#1246

World Rank

#1273

Historical Rank

Biochemistry

#1396

World Rank

#1520

Historical Rank

biology Degrees

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Chemistry
Biology

Gerd Multhaup's Degrees

PhD Biochemistry University of Konstanz
Masters Chemistry University of Konstanz
Bachelors Chemistry University of Konstanz

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Gerd Multhaup's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Amyloid plaque core protein in Alzheimer disease and Down syndrome. (1985) (4087)
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor (1987) (3948)
Rapid induction of Alzheimer A beta amyloid formation by zinc. (1994) (1389)
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. (1999) (1048)
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. (1985) (1016)
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. (1999) (708)
The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I) (1996) (648)
The precursor of Alzheimer??s disease amyloid A4 protein resembles a cell-surface receptor (1987) (642)
Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch (2001) (452)
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. (1988) (433)
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. (1989) (427)
Copper in disorders with neurological symptoms: Alzheimer’s, Menkes, and Wilson diseases (2001) (418)
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. (1988) (364)
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease (1988) (363)
Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes (1994) (344)
A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide – the first step of a fatal cascade (2004) (335)
The major polypeptide of scrapie‐associated fibrils (SAF) has the same size, charge distribution and N‐terminal protein sequence as predicted for the normal brain protein (PrP). (1986) (335)
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice (2003) (327)
The LPS receptor (CD14) links innate immunity with Alzheimer's disease (2004) (316)
Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein (1992) (309)
Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice (2001) (308)
A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. (1996) (296)
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42 (2007) (289)
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease. (1993) (288)
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. (2004) (279)
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice (1999) (278)
Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families (1987) (274)
Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites (1991) (266)
Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain (2003) (259)
Phosphorylation Regulates Intracellular Trafficking of β-Secretase* (2001) (257)
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein (1999) (244)
Maturation and Pro-peptide Cleavage of β-Secretase* (2000) (234)
Fibrils from brains of cows with new cattle disease contain scrapie-associated protein (1988) (232)
The cellular prion protein mediates neurotoxic signalling of β‐sheet‐rich conformers independent of prion replication (2011) (229)
The βA4 amyloid precursor protein binding to copper (1994) (228)
Reactive oxygen species and Alzheimer's disease. (1997) (222)
Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor (1990) (218)
Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease* (2001) (216)
The Alzheimer's Disease Amyloid Precursor Protein Modulates Copper-Induced Toxicity and Oxidative Stress in Primary Neuronal Cultures (1999) (214)
Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. (2001) (209)
Processing of β-Secretase by Furin and Other Members of the Proprotein Convertase Family* (2001) (194)
Production of intracellular amyloid‐containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. (1995) (187)
Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3 (1990) (174)
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. (2001) (174)
Key Factors in Alzheimer's Disease: β‐amyloid Precursor Protein Processing, Metabolism and Intraneuronal Transport (2001) (174)
Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I (*) (1996) (168)
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons (1996) (165)
Copper Depletion Down-regulates Expression of the Alzheimer's Disease Amyloid-β Precursor Protein Gene* (2004) (165)
Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion. (1999) (160)
Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc (2006) (156)
Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes. (1990) (154)
Clioquinol Mediates Copper Uptake and Counteracts Copper Efflux Activities of the Amyloid Precursor Protein of Alzheimer's Disease* (2004) (152)
Phosphorylation regulates intracellular trafficking of beta-secretase. (2001) (150)
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain DOI 10.1194/jlr.M200071-JLR200 (2002) (150)
Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons. (1997) (142)
The beta‐amyloid domain is essential for axonal sorting of amyloid precursor protein. (1996) (142)
Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide. (1998) (132)
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer’s disease (2006) (128)
Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie. (1988) (128)
The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production (2013) (124)
A Family Knockout of All Four Drosophila Metallothioneins Reveals a Central Role in Copper Homeostasis and Detoxification (2006) (123)
Regulation and Expression of the Alzheimer's β/A4 Amyloid Protein Precursor in Health, Disease, and Down's Syndrome a (1993) (123)
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. (1989) (121)
Intraneuronal APP/Aβ Trafficking and Plaque Formation in β‐Amyloid Precursor Protein and Presenilin‐1 Transgenic Mice (2002) (116)
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. (1997) (115)
It all sticks together—the APP-related family of proteins and Alzheimer's disease (1999) (111)
Proteolytic Processing of Alzheimer's Disease βA4 Amyloid Precursor Protein in Human Platelets (*) (1995) (110)
Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions* (2013) (110)
Role of Amyloid-β Glycine 33 in Oligomerization, Toxicity, and Neuronal Plasticity (2009) (109)
Molecular characterization of two invariant surface glycoproteins specific for the bloodstream stage of Trypanosoma brucei. (1992) (107)
Relative Increase in Alzheimer’s Disease of Soluble Forms of Cerebral Aβ Amyloid Protein Precursor Containing the Kunitz Protease Inhibitory Domain* (1998) (106)
The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species* (2012) (105)
Maturation and pro-peptide cleavage of beta-secretase. (2000) (105)
Amyloid beta 42 peptide (Aβ42)-lowering compounds directly bind to Aβ and interfere with amyloid precursor protein (APP) transmembrane dimerization (2010) (103)
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases (2009) (99)
Survival of Cultured Neurons from Amyloid Precursor Protein Knock-Out Mice against Alzheimer’s Amyloid-β Toxicity and Oxidative Stress (1998) (98)
Dimerization of β-Site β-Amyloid Precursor Protein-cleaving Enzyme* (2004) (98)
Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence. (1987) (96)
Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect β-Secretase Cleavage of APP* (2008) (95)
Interaction between the zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP) (1994) (95)
Intake of copper has no effect on cognition in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial (2008) (94)
GABAA-receptor expressed from rat brain α- and β-subunit cDNAs displays potentiation by benzodiazepine receptor ligands (1990) (94)
Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain. (2012) (94)
Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity (1999) (92)
The Mechanism of Nucleotide-assisted Molybdenum Insertion into Molybdopterin (2006) (90)
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2 (2009) (89)
Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. (2010) (88)
Mutations in the transmembrane domain of APP altering gamma-secretase specificity. (1997) (88)
Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch (2000) (88)
Proteome of metastatic canine mammary carcinomas: similarities to and differences from human breast cancer. (2010) (84)
Cognitive decline correlates with low plasma concentrations of copper in patients with mild to moderate Alzheimer's disease. (2005) (83)
Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer’s disease (2006) (83)
Human BACE Forms Dimers and Colocalizes with APP* (2004) (82)
Environmental Copper and Manganese in the Pathophysiology of Neurologic Diseases (Alzheimer's Disease and Manganism)† (2005) (78)
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease. (2000) (77)
A Splice Variant of β-Secretase Deficient in the Amyloidogenic Processing of the Amyloid Precursor Protein* (2001) (77)
A vicious circle: role of oxidative stress, intraneuronal Abeta and Cu in Alzheimer's disease. (2006) (76)
Contrasting, Species-Dependent Modulation of Copper-Mediated Neurotoxicity by the Alzheimer's Disease Amyloid Precursor Protein (2002) (75)
Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycans. (1994) (75)
IGF-1-induced Processing of the Amyloid Precursor Protein Family Is Mediated by Different Signaling Pathways* (2007) (75)
Mammalian single‐stranded DNA binding protein UP I is derived from the hnRNP core protein A1. (1986) (75)
Interaction of the CopZ copper chaperone with the CopA copper ATPase of Enterococcus hirae assessed by surface plasmon resonance. (2001) (74)
Kinetic Analysis of the Interaction of the Copper Chaperone Atox1 with the Metal Binding Sites of the Menkes Protein* (2003) (72)
Localization of the putative precursor of Alzheimer's disease‐specific amyloid at nuclear envelopes of adult human muscle. (1988) (71)
The PROS‐35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome. (1989) (70)
The beta A4 amyloid precursor protein binding to copper. (1994) (70)
Hohenheim Consensus Workshop: Copper (2002) (69)
Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. (1997) (65)
Alzheimer β-Amyloid Homodimers Facilitate Aβ Fibrillization and the Generation of Conformational Antibodies* (2003) (63)
The protein component of scrapie‐associated fibrils is a glycosylated low molecular weight protein. (1985) (62)
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice. (2002) (62)
Structural and Mechanistic Implications of Metal Binding in the Small Heat-shock Protein αB-crystallin* (2011) (61)
Identification of a β-Secretase Activity, Which Truncates Amyloid β-Peptide after Its Presenilin-dependent Generation* (2003) (61)
Interaction kinetics of the copper-responsive CopY repressor with the cop promoter of Enterococcus hirae (2004) (61)
Proteolytic Fragments of Alzheimer’s Disease‐Associated Presenilin 1 Are Present in Synaptic Organelles and Growth Cone Membranes of Rat Brain (1999) (60)
Aberrant Amyloid Precursor Protein (APP) Processing in Hereditary Forms of Alzheimer Disease Caused by APP Familial Alzheimer Disease Mutations Can Be Rescued by Mutations in the APP GxxxG Motif* (2010) (60)
Mechanisms of Amyloid Deposition in Alzheimer's Disease a (1991) (59)
Reelin in plaques of β-amyloid precursor protein and presenilin-1 double-transgenic mice (2001) (57)
Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers (2012) (57)
Receptor recognition by a hepatitis B virus reveals a novel mode of high affinity virus–receptor interaction (2000) (56)
Effect of copper intake on CSF parameters in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial (2008) (55)
Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptor. (1990) (55)
Gender dependent APP processing in a transgenic mouse model of Alzheimer’s disease (2007) (51)
No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the β-cleaved C-terminal APP fragment (2003) (50)
Evidence for a copper-binding superfamily of the amyloid precursor protein. (2002) (49)
A novel substrate for analyzing Alzheimer's disease γ‐secretase (1999) (48)
The Drosophila PROS-28.1 gene is a member of the proteasome gene family. (1990) (48)
The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization. (2012) (47)
The Amyloid Precursor Protein (APP) of Alzheimer Disease and Its Paralog, APLP2, Modulate the Cu/Zn-Nitric Oxide-catalyzed Degradation of Glypican-1 Heparan Sulfate in Vivo* (2005) (47)
Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels (2007) (46)
Amyloid precursor protein, copper and Alzheimer's disease. (1997) (46)
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. (2004) (45)
Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability (2011) (45)
Insulin-like Growth Factor-1 (IGF-1)-induced Processing of Amyloid-β Precursor Protein (APP) and APP-like Protein 2 Is Mediated by Different Metalloproteinases* (2010) (45)
Human Brain βA4 Amyloid Protein Precursor of Alzheimer's Disease: Purification and Partial Characterization (1992) (45)
Stage-specific Proteophosphoglycan from Leishmania mexicana Amastigotes (1998) (42)
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms (2011) (41)
Lewy body variant of Alzheimer's disease: α‐synuclein in dystrophic neurites of Aβ plaques (2000) (41)
Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer's Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity. (2016) (40)
Disturbed Copper Bioavailability in Alzheimer's Disease (2011) (39)
Cellular copper import by nanocarrier systems, intracellular availability, and effects on amyloid beta peptide secretion. (2009) (37)
Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimers Disease (2011) (37)
Alzheimer's Disease βA4 Protein Release and Amyloid Precursor Protein Sorting Are Regulated by Alternative Splicing* (1996) (36)
Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer’s disease (1997) (36)
Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein (1998) (35)
Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease. (2011) (35)
Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation. (2011) (35)
Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease. (2002) (33)
Involvement of amyloid β precursor protein (AβPP) modulated copper homeostasis in Alzheimer's disease (2005) (32)
Effect of copper and manganese on the de novo generation of protease-resistant prion protein in yeast cells. (2006) (30)
Diverse fibrillar peptides directly bind the Alzheimer’s amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation (2003) (29)
Is there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors? (2011) (29)
Understanding the Interaction of Polyelectrolyte Architectures with Proteins and Biosystems (2020) (28)
Metal binding and radical generation of proteins in human neurological diseases and aging. (1999) (28)
Real-time kinetics of discontinuous and highly conformational metal-ion binding sites of prion protein (2007) (27)
Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide* (2015) (27)
Specific binding of the alzheimer βA4 amyloid precursor to collagen, laminin, and heparin (1992) (25)
Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques. (2000) (25)
A novel substrate for analyzing Alzheimer's disease gamma-secretase. (1999) (25)
Amyloid precursor protein (APP) and beta A4 amyloid in Alzheimer's disease and Down syndrome. (1992) (25)
The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators. (2011) (24)
A Soluble Form of the Avian Hepatitis B Virus Receptor (1999) (23)
Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokines a (1996) (23)
Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies. (2003) (22)
Copper is required for prion protein‐associated superoxide dismutase‐l activity in Pichia pastoris (2007) (21)
Amyloid Precursor Protein and BACE Function as Oligomers (2006) (21)
Alzheimer's Precursor Protein and the Use of Bathocuproine for Determining Reduction of Copper(II) (1996) (20)
Reverse relationship between β-amyloid precursor protein and β-amyloid peptide plaques in Down’s syndrome versus sporadic/familial Alzheimer’s disease (1999) (20)
The Cleavage Domain of the Amyloid Precursor Protein Transmembrane Helix Does Not Exhibit Above‐Average Backbone Dynamics (2013) (19)
Differential effects of zinc on amyloid precursor protein (APP) processing in copper-resistant variants of cultured Chinese hamster ovary cells. (2000) (19)
Detection of prion epitopes on PrPc and PrPsc of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP (2005) (19)
GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands. (1990) (18)
Biocompatible, hyperbranched nanocarriers for the transport and release of copper ions. (2014) (17)
Drosophila proteasome Dm25 subunit substitutes the mouse MC3 subunit in hybrid proteasomes. The N-terminal domain is essential for subunit incorporation. (1993) (17)
Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease (2010) (16)
Interferon " y Stimulation Modulates the Proteolytic Activity and Cleavage Site Preference of 20 S Mouse Proteasomes (1994) (15)
Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization (2017) (15)
Dimerization of the cellular prion protein inhibits propagation of scrapie prions (2018) (14)
[The role of copper in the pathophysiology of Alzheimer's disease]. (2005) (13)
Involvement of amyloid beta precursor protein (AbetaPP) modulated copper homeostasis in Alzheimer's disease. (2005) (13)
Alzheimer's disease: genesis of amyloid. (1996) (12)
Zur Bedeutung von Kupfer für die Pathophysiologie der Alzheimer-Krankheit (2005) (12)
Model peptides uncover the role of the β-secretase transmembrane sequence in metal ion mediated oligomerization. (2013) (12)
A molecular approach to Alzheimer's disease. (1993) (11)
Peptides based on the presenilin‐APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain (2012) (11)
Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes (2015) (11)
Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers (2011) (10)
Light‐Controlled Toxicity of Engineered Amyloid β‐Peptides (2012) (10)
Suppression of Amyloid β A11 Antibody Immunoreactivity by Vitamin C (2011) (10)
Copper transport mediated by nanocarrier systems in a blood-brain barrier in vitro model. (2014) (10)
Autoxidation of amyloid precursor protein and formation of reactive oxygen species. (1999) (8)
398 EVIDENCE OF A DIRECT MAS-AT2 RECEPTOR DIMERIZATION (2012) (8)
The Heat Shock Response Is Modulated by and Interferes with Toxic Effects of Scrapie Prion Protein and Amyloid β* (2012) (8)
Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease. (1999) (7)
Amyloid BA4 protein pathology is central to the cause of Alzheimer's disease (1990) (7)
Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors. (2013) (7)
Serine 71 of the glycoprotein HEF is located at the active site of the acetylesterase of influenza C virus (2005) (6)
Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. (1991) (6)
Novel APP/Ab mutation K16N produces highly toxic heteromeric Ab oligomers (2012) (5)
619 Reduction of copper(II) to copper(I) by the Amyloid Precursor Protein (APP) of Alzheimer's disease (1996) (5)
PHOSPHORYLATION REGULATES INTRACELLULAR TRAFFICKING OF ß-SECRETASE ( BACE ) (2001) (4)
Importance of Copper and Zinc in Alzheimer's Disease and the Biology of Amyloid-β Protein and Amyloid-β Protein Precursor (2003) (4)
Studies of the Amyloid Precursor Protein (APP) in Brain: Regulation of APP-Ligand Binding (1994) (4)
Human brain beta A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization. (1992) (3)
O3-04-06 Structural and functional analysis of the Alzheimer's disease amyloid precursor protein copper binding domain (2004) (3)
The metalloprotease meprin beta generates amino-terminally truncated beta-amyloid peptide species (2012) (3)
FRUCTUS GARDENIAE AND FOR TREATING NEURODEGENERATIVE DISEASES (2017) (3)
Copper and clioquinol treatment in young APP transgenic and wildtype mice: effects on life expectancy, body weight and metal-ion levels (2007) (3)
Role of Copper and Other Transition Metal Ions in the Pathogenesis of Parkinson’s Disease, Prion Diseases, Familial Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease (2002) (3)
MOLECULAR PATHOLOGY OF THE AMYLOID A4 PRECURSOR OF ALZHEIMER'S DISEASE (1989) (2)
Regulation of the Amyloid Gene of Alzheimer’s Disease (1990) (2)
UvA-DARE ( Digital Academic Repository ) Pyroglutamate Abeta pathology in APP / PS 1 KI mice , sporadic and familial Alzheimer ’ s disease cases (2009) (2)
Structural mechanism of the interaction of Alzheimer's disease Aβ fibrils with the NSAID sulindac sulfide (2015) (2)
Precursor of Alzheimer’s Disease (PAD) A4 Amyloid Protein (1988) (2)
Screening und Charakterisierung von Protein-modifizierenden Naturstoffen durch MALDI-Massenspektrometrie bringen starke SIRT1- und p300-Inhibitoren hervor† (2013) (1)
The Molecular Basis of Cerebral Amyloidosis in Alzheimer’s Disease and the Unconventional Virus Diseases (1988) (1)
The Role of Metal Ions in the Amyloid Precursor Protein and in Alzheimer's Disease (2006) (1)
Molecular Biology and Pathology of Alzheimer’s Disease (1993) (1)
P1-122: Dissection of the individual domains of APP family members involved in homo- and heterotypic interactions (2008) (1)
Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid β, by Robin Harris and Falk Fahrenholz (2005) (1)
P2-056 Homo-and heterophilic interactions of APP-family-proteins (2006) (1)
Wechselwirkung von Polyelektrolyt‐Architekturen mit Proteinen und Biosystemen (2020) (1)
Mechanism of gamma-secretase-mediated APP processing and modulation (2012) (1)
SUPPRESSION OF AMYLOID BETA A11-IMMUNOREACTIVITY BY VITAMIN C: POSSIBLE ROLE OF HEPARAN SULFATE OLIGOSACCHARIDES DERIVED FROM GLYPICAN-1 BY ASCORBATE-INDUCED, NO-CATALYZED DEGRADATION (2011) (1)
Core-shell based nanocarriers as delivery systems for biologically active metal ions and drugs (2008) (1)
Kupferagonist, which binds to the copper binding site of amyloid precursor protein (APP) and / or exerts an inhibitory effect on the release of the amyloid-beta-peptide (2000) (0)
Composes pour le diagnostic/prevention/traitement de la maladie d'alzheimer (2002) (0)
Cellular Mechanisms of Alzheimer's Disease (2006) (0)
Alzheimer‘s disease and gene regulation: A possible role of Aß in the nucleus (2010) (0)
Methode d'identification d'inhibiteurs de la maladie d'alzheimer (2001) (0)
Six Years of Collaborative Alzheimer’s Disease Research in Germany (2006) (0)
SorLA/LR11 affects processing op APP and the APP-like proteins 1 and -2 (2010) (0)
N-TERMINAL DOMAIN OF THE AMYLOID PRECURSOR PROTEIN (2000) (0)
426 APP shares glycan modifications characteristic of cell adhesion molecules (1996) (0)
O4-06-02 Role of single amino acids of the Aβ sequence on cytotoxicity and inhibition of LTP (2006) (0)
Role of the amyloid precursor protein and copper in Alzheimer's disease (2013) (0)
P1-042 Neuronal loss and changes in metal homeostasis in the APP751SLPS1ki mouse model of Alzheimer’s disease (2006) (0)
P4-190 MONOACYLGLYCEROL LIPASE CONTRIBUTES TO PATHOGENESIS OFALZHEIMER’S DISEASE (2019) (0)
Aβ42-lowering compounds interfere with APP transmembrane sequence dimerization (2010) (0)
Crystal Structure of the N-terminal Heparin-Binding Domain of Alzheimer's Amyloid Precursor Protein (2000) (0)
Divalent metal ion-loaded nano-transport system with dendritic architecture for therapy (2008) (0)
Differential interaction of beta-amyloid-42 and beta-amyloid-40 to plasma membrane lipids (2012) (0)
A Presenilin Dependent S3-Like γ-Secretase Cleavage of the β-Amyloid Precursor Protein (2002) (0)
Discovery and Characterization of Protein-Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT 1 and p 300 Inhibitors * * (2013) (0)
Meeting Report: 7th Fabisch Symposium for Cancer Research and Molecular Cell Biology - Regulated Intramembrane Proteolysis in Cancer Development and Neurodegenerative Diseases (2012) (0)
O2-04-06 New lessons form the APP/PS1 transgenic mouse model with neuron loss: Metal biology, axonal degeneration and intraneuronal N-modified Aβ aggregation (2006) (0)
Molecular Pathology and Aetiology of Alzheimer’s Disease (1992) (0)
APP and APLP2 are processed by different enzymes during induced conditions (2010) (0)
Effects of copper and zinc on amyloid precursor protein function and metabolism (2000) (0)
Hippocampal neuron loss is greater than amyloid plaque load in a transgenic mouse model of Alzheimer’s disease (2004) (0)
Animal Model Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease (2004) (0)
S.11.01 The amyloid hypothesis in Alzheimer's disease and its implication for therapy: A review of evidence (1996) (0)
Regulated Intramembrane Proteolysis in Cancer Development and Neurodegenerative Diseases (2013) (0)
THE BIOLOGICAL ACTIVITIES AND FUNCTION OF THE AMYLOID PRECURSOR PROTEIN OF ALZHEIMER’S DISEASE (1998) (0)
The structure and function of the amyloid precursor protein N-terminal region (2000) (0)
Structural dynamics of the transmembrane domain of the amyloid precursor protein (APP) determined by deuterium/hydrogen exchange (2009) (0)
483 Inverse Relationship Between BAPP and BAP Expression in the Pathogenesis of Neuritic Plaques (1996) (0)
Table of Contents (1995) (0)
O1-02-05 Dimerization of the APP transmembrane sequence is critical for Aβ42 generation (2006) (0)
Foot-and-Mouth Disease VirusProtease 3CInduces Specific Proteolytic Cleavage ofHostCellHistone H3 (1990) (0)
9 – The Copper Binding Domain of the Amyloid Precursor Protein of Alzheimer's Disease can Modulate Copper Homeostasis and Regulate Amyloid Aß Production (2002) (0)
CHAPTER 6 – Molecular biology and pathology of Alzheimer's disease (1993) (0)
THE CYSTEINE-RICH DOMAIN OF THE AMYLOID PRECURSOR PROTEIN (APP) CONTAINS SIX DISULPHIDE BRIDGES IN TWO SUBDOMAINS (2000) (0)
O1-03-04: Deleterious effects of familial Alzheimer's disease (FAD) mutations in APP are mediated through the GxxxG interaction motif (2008) (0)
S.24.02 The cell biology of Abeta generation (2009) (0)
789 Exon 15 of APP regulates βA4 production and polarized secretion of APP (1996) (0)
IDENTIFICATION OF LOW MOLECULAR WEIGHT N-TRUNCATED ABETA OLIGOMERS IN ALZHEIMER DISEASE : A NOVEL TOOL FOR THERAPY AND DIAGNOSIS (2011) (0)
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms (2011) (0)
P1-211 Characterization of Aβ-dimerization in an in vivo transmembrane dimerization selection system (2004) (0)
Analysis for the diagnosis of Alzheimer's disease based on determining the proportion of cleavage products ab secretase. (2006) (0)
P1-375 Dietary copper recovers young APP transgenic mice from adverse effects of clioquinol (2006) (0)
Contents Vol. 11, 2013 (2013) (0)
425 Alternative splicing of exon 15 regulates APP conformation (1996) (0)
The amyloid gene and neuronal dysfunction in Alzheimer's disease (1989) (0)
Reassessment of APP Familial Alzheimer's Disease (FAD) mutations (2009) (0)
Characterization of metal binding of beta-site APP-cleaving enzyme 1 (BACE1) (2005) (0)
Contents of Volumes in the Metal Ions in Life Sciences Series (2019) (0)
297 Molecular dissection of APP and βA4/Aβ pathology and neurodegeneration in Alzheimer's disease (1996) (0)
Homophilic interactions of the APP ectodomain are regulated by the loop region and affect ß-secretase cleavage of APP (2007) (0)
Microsoft Word-HS-Abeta_conjugates-jbc-text o referens-revised.docx (2011) (0)
P4-037 Important role of PRP in metal-ion homeostasis (2004) (0)
Membrane Protein Function and Transmembrane Helix Backbone Dynamics (2012) (0)
ThePROS-35 gene encodes the35kdprotein subunit ofDrosophila melanogaster proteasome (1989) (0)
Table of Contents (1985) (0)
Kupferagonist which binds to the copper binding site of APP and / or exerts an inhibitory effect on the release of the amyloid Aß-peptide (1999) (0)
P1-427: The GxxxG motif of the Aβ sequence unlinks Aβ aggregation from toxicity (2008) (0)
Title Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S 3 cleavage of Notch Permalink (2013) (0)
Mapping the Backbone Dynamics of the Alzheimer's APP Transmembrane Domain (2012) (0)
Genetics, Expression and Localization of the Amyloid Precursor of Alzheimer’s Disease (1988) (0)
Aggregation of Aß42 is strongly influenced by Gly33 of the GxxxG motif and an inhibitor peptide which mimics Gly33 substitutions (2011) (0)
Nsaids modulate app dimerization (2009) (0)
Zinc-dependent oligomerization of APP family proteins (2012) (0)

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