Gerd‐achim Kullak‐ublick
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(Suggest an Edit or Addition)Gerd‐achim Kullak‐ublick's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci (2010) (2516)
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013) (1068)
- Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. (2001) (740)
- Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection (2020) (684)
- Enterohepatic bile salt transporters in normal physiology and liver disease. (2004) (597)
- St John's Wort induces intestinal P‐glycoprotein/MDR1 and intestinal and hepatic CYP3A4 (2000) (586)
- Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. (2000) (545)
- EASL Clinical Practice Guidelines: Drug-induced liver injury. (2019) (443)
- Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. (1995) (420)
- Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. (2000) (395)
- Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity (2009) (361)
- Drug-induced liver injury: recent advances in diagnosis and risk assessment (2017) (319)
- Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury (2007) (300)
- Epidemiology of drug exposure and adverse drug reactions in two swiss departments of internal medicine. (2000) (292)
- Hepatic transport of bile salts. (2000) (288)
- Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. (2004) (255)
- Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. (2011) (251)
- Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism. (2005) (242)
- Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C–dependent mechanisms in cholestatic rat liver (2001) (239)
- Regional Distribution of Solute Carrier mRNA Expression Along the Human Intestinal Tract (2007) (225)
- Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis (2003) (212)
- The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-α and -β genes (2006) (187)
- Enterohepatic transport of bile salts and genetics of cholestasis. (2005) (178)
- Hepatocyte nuclear factor 1α: A key mediator of the effect of bile acids on gene expression (2003) (175)
- BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis (2004) (174)
- Transport of bile acids in hepatic and non-hepatic tissues. (2001) (168)
- Characterization of the Human OATP-C (SLC21A6) Gene Promoter and Regulation of Liver-specific OATP Genes by Hepatocyte Nuclear Factor 1α* (2001) (165)
- Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump. (2008) (165)
- Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. (1997) (163)
- Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. (2002) (157)
- Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study. (2017) (157)
- Functional characterization of the basolateral rat liver organic anion transporting polypeptide (1994) (155)
- Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. (2003) (150)
- Lipid Accumulation and Chronic Kidney Disease (2019) (146)
- Changes in mRNA Expression Levels of Solute Carrier Transporters in Inflammatory Bowel Disease Patients (2009) (146)
- 7 alpha-dehydroxylating bacteria enhance deoxycholic acid input and cholesterol saturation of bile in patients with gallstones. (1996) (142)
- Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: An international collaborative effort (2018) (142)
- Pharmacogenetics of drug‐induced liver injury (2010) (139)
- Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis. (2005) (138)
- Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. (1996) (136)
- Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain (1998) (124)
- The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism. (2006) (124)
- Protein kinase C–dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells (2001) (122)
- Drug-induced liver injury (2015) (115)
- Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. (2008) (115)
- Drug-induced liver injury (2019) (114)
- Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells (1996) (113)
- Hepatobiliary transport. (2000) (113)
- Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver (2001) (110)
- Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene. (2004) (110)
- Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression. (2003) (109)
- The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. (2004) (108)
- Human Apical Sodium-dependent Bile Salt Transporter Gene (SLC10A2) Is Regulated by the Peroxisome Proliferator-activated Receptor α* (2002) (108)
- The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. (2006) (107)
- The Human Organic Cation Transporter-1 Gene Is Transactivated by Hepatocyte Nuclear Factor-4α (2006) (102)
- Regulation of Drug and Bile Salt Transporters in Liver and Intestine (2003) (100)
- Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study. (2012) (97)
- Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis. (2001) (93)
- Genetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11) (2006) (91)
- The role of FXR in disorders of bile acid homeostasis. (2008) (89)
- hPepT1 selectively transports muramyl dipeptide but not Nod1-activating muramyl peptides. (2006) (89)
- Mechanisms of action of plant sterols on inhibition of cholesterol absorption (2005) (88)
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013) (84)
- The Human Organic Anion Transporter 2 Gene Is Transactivated by Hepatocyte Nuclear Factor-4α and Suppressed by Bile Acids (2005) (83)
- Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat. (2003) (83)
- Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy (2007) (82)
- Long‐term effects of cholecystectomy on bile acid metabolism (1995) (80)
- Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene (1997) (79)
- Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C: a randomized phase II trial. (2006) (78)
- Colectomy Rates in Ulcerative Colitis are Low and Decreasing: 10-year Follow-up Data From the Swiss IBD Cohort Study (2018) (78)
- Hepatotoxicity following administration of onasemnogene abeparvovec (AVXS-101) for the treatment of spinal muscular atrophy. (2020) (77)
- Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes (1999) (75)
- A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury. (2019) (75)
- Crohn's disease‐associated polymorphism within the PTPN2 gene affects muramyl‐dipeptide‐induced cytokine secretion and autophagy (2012) (75)
- Mechanisms of cholestasis. (2000) (74)
- Drugs and hepatic transporters: A review. (2020) (73)
- Microlithiasis and sludge (2006) (73)
- Mushroom poisoning: a study on circumstances of exposure and patterns of toxicity. (2012) (70)
- Cost-effectiveness of cadaveric and living-donor liver transplantation (2002) (68)
- A Mobile App to Stabilize Daily Functional Activity of Breast Cancer Patients in Collaboration With the Physician: A Randomized Controlled Clinical Trial (2016) (68)
- Vitamin D3 and Its Nuclear Receptor Increase the Expression and Activity of the Human Proton-Coupled Folate Transporter (2009) (67)
- Fatal hepatotoxicity secondary to nimesulide (2001) (66)
- Regulation of organic anion and drug transporters of the sinusoidal membrane. (1999) (65)
- Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease (2011) (65)
- Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver. (2001) (65)
- Risks of Inflammatory Bowel Disease Treatment with Glucocorticosteroids and Aminosalicylates (2013) (63)
- Molecular Mechanisms of Colistin-Induced Nephrotoxicity (2019) (61)
- Analysis of Risk Factors for Low Bone Mineral Density in Inflammatory Bowel Disease (2006) (61)
- G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation (2015) (61)
- Arterial and venous pharmacokinetics of intravenous heroin in subjects who are addicted to narcotics (2001) (60)
- Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor (2016) (59)
- Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation (2018) (59)
- Coordinate transcriptional regulation of transport and metabolism. (2005) (59)
- Acute plant poisoning: Analysis of clinical features and circumstances of exposure (2011) (58)
- Rivaroxaban postmarketing risk of liver injury. (2014) (57)
- Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity (2007) (57)
- Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. (2001) (56)
- Pharmacokinetics of high doses of intramuscular and oral heroin in narcotic addicts (2003) (55)
- Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice* (2015) (55)
- Bile acids in drug induced liver injury: Key players and surrogate markers. (2016) (54)
- Expression of the hepatocyte canalicular multidrug resistance protein (MRP2) in primary biliary cirrhosis. (2002) (53)
- Drug-induced bile duct injury. (2017) (53)
- Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition (2007) (51)
- Mechanisms of action of plant sterols on inhibition of cholesterol absorption (2011) (50)
- Interactions of glycyrrhizin with organic anion transporting polypeptides of rat and human liver. (2003) (50)
- Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury. (2018) (50)
- Hepatocyte Nuclear Factor (HNF) 1 and HNF4 Mediate Hepatic Multidrug Resistance Protein 2 Up-Regulation during Hepatitis C Virus Gene Expression (2006) (48)
- Stable expression and functional characterization of a Na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells (2000) (47)
- Fc Gamma Receptor CD64 Modulates the Inhibitory Activity of Infliximab (2012) (47)
- Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study. (2020) (46)
- Ribavirin/interferon-α sequential treatment of recurrent hepatitis C after liver transplantation (2004) (46)
- Evaluation of Drug Interactions in a Large Sample of Psychiatric Inpatients: A Data Interface for Mass Analysis With Clinical Decision Support Software (2011) (46)
- 3.5 Clinical Decision Support Systems (2012) (45)
- Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease (2012) (45)
- Drug-induced liver injury: the dawn of biomarkers? (2015) (43)
- Tumor necrosis factor-α and interferon-γ increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine (2006) (43)
- Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage (2017) (42)
- Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney. (2014) (42)
- The SLCO1A2 Gene, Encoding Human Organic Anion-Transporting Polypeptide 1A2, Is Transactivated by the Vitamin D Receptor (2012) (40)
- Urinary Excretion of Melatonin and Association with Breast Cancer: Meta-Analysis and Review of the Literature (2014) (39)
- Cholestasis protects the liver from ischaemic injury and post-ischaemic inflammation in the mouse (2006) (38)
- TNF-α Deficiency Prevents Renal Inflammation and Oxidative Stress in Obese Mice (2017) (38)
- Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis (2004) (37)
- Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters. (2014) (37)
- Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity (2016) (36)
- Gallstone disease: Microlithiasis and sludge. (2006) (36)
- fMLP induces Hsp27 expression, attenuates NF-kappaB activation, and confers intestinal epithelial cell protection. (2007) (35)
- Comparison of sitosterol and sitostanol on inhibition of intestinal cholesterol absorption. (1988) (35)
- Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor (2003) (35)
- Comparative evaluation of three clinical decision support systems: prospective screening for medication errors in 100 medical inpatients (2012) (34)
- Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs (2004) (34)
- Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology (2020) (33)
- First clinical experience with Molecular Adsorbent Recirculating System (MARS) in six patients with severe acute on chronic liver failure. (2002) (32)
- Methodology to Assess Clinical Liver Safety Data (2014) (32)
- Thermoplasmonic-Assisted Cyclic Cleavage Amplification for Self-Validating Plasmonic Detection of SARS-CoV-2 (2021) (32)
- Downregulation of the hepatocellular organic anion transporters OATP-C and MRP2 in patients with primary sclerosing cholangitis (2000) (32)
- The Human Organic Anion Transporter Genes OAT5 and OAT7 Are Transactivated by Hepatocyte Nuclear Factor-1α (HNF-1α) (2010) (31)
- Safety and efficacy of repeated shockwave lithotripsy of gallstones with and without adjuvant bile acid therapy. (1997) (31)
- Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. (2016) (31)
- Medical Treatment of Primary Sclerosing Cholangitis: A Role for Novel Bile Acids and other (post-)Transcriptional Modulators? (2009) (30)
- Potentially inappropriate prescribing for elderly outpatients in Germany: a retrospective claims data analysis. (2012) (30)
- Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68) (2016) (30)
- Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase (2014) (30)
- The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment. (2015) (29)
- Escitalopram causes fewer seizures in human overdose than citalopram (2010) (29)
- Liver Safety Assessment in Special Populations (Hepatitis B, C, and Oncology Trials) (2014) (28)
- Effect of cholestyramine on bile acid pattern and synthesis during administration of ursodeoxycholic acid in man. (2000) (28)
- Constitutive rat multidrug-resistance protein 2 gene transcription is down-regulated by Y-box protein 1. (2003) (28)
- Clinical Usefulness of Electronic Drug-Drug Interaction Checking in the Care of Cardiovascular Surgery Inpatients (2012) (27)
- Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization. (1996) (27)
- microRNA-192 suppresses the expression of the farnesoid X receptor. (2016) (27)
- Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine. (2006) (26)
- Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment. (2012) (26)
- Therapeutic Drug Monitoring of Daptomycin: A Retrospective Monocentric Analysis (2013) (26)
- Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients. (2010) (26)
- Impact of variable CYP genotypes on breast cancer relapse in patients undergoing adjuvant tamoxifen therapy (2014) (24)
- Drug-related problems and factors influencing acceptance of clinical pharmacologists` alerts in a large cohort of neurology inpatients. (2012) (24)
- Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations (2013) (23)
- Diagnosis of melanoma under concomitant natalizumab therapy (2011) (23)
- Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2. (2012) (23)
- Best practices for detection, assessment and management of suspected immune-mediated liver injury caused by immune checkpoint inhibitors during drug development. (2020) (23)
- Tauroursodeoxycholic acid mobilizes α‐PKC after uptake in human HepG2 hepatoma cells (2002) (22)
- Cohort Profile Update: The Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). (2019) (22)
- Successful use of the Molecular Adsorbent Recirculating System (MARS) in a patient with primary biliary cirrhosis (PBC) and treatment refractory pruritus. (2003) (22)
- The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes (2014) (22)
- A MIR4646 associated methylation locus is hypomethylated in adolescent depression. (2017) (22)
- The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation (2019) (22)
- Ursodeoxycholic acid reduces lipid peroxidation and mucin secretagogue activity in gallbladder bile of patients with cholesterol gallstones (2008) (21)
- Colistin is Substrate of the Carnitine/Organic Cation Transporter 2 (OCTN2, SLC22A5) (2017) (21)
- Gastric pharmacobezoars in quetiapine extended-release overdose: A case series (2013) (20)
- Electronic prescribing increases uptake of clinical pharmacologists' recommendations in the hospital setting. (2011) (20)
- Management of the Elderly Inflammatory Bowel Disease Patient (2020) (20)
- Lipid peroxidation and mucin secretagogue activity in bile of gallstone patients (2007) (19)
- Fatal hepatoxicity secondary to nimesulide. (2001) (18)
- Octreotide Inhibits the Bilirubin Carriers Organic Anion Transporting Polypeptides 1B1 and 1B3 and the Multidrug Resistance-Associated Protein 2 (2015) (18)
- Hypermethylation-associated downregulation of microRNA-4456 in hypersexual disorder with putative influence on oxytocin signalling: A DNA methylation analysis of miRNA genes (2019) (18)
- HER2/CEP17 Ratios and Clinical Outcome in HER2-Positive Early Breast Cancer Undergoing Trastuzumab-Containing Therapy (2016) (18)
- Ribavirin/interferon‐α sequential treatment of recurrent hepatitis C after liver transplantation (2004) (18)
- Expression of a rat liver phosphatidylcholine translocator in Xenopus laevis oocytes (1996) (18)
- Atypical antipsychotic poisoning in young children: a multicentre analysis of poisons centres data (2014) (17)
- Quantification of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry (2013) (17)
- Evaluation of drug interactions and dosing in 484 neurological inpatients using clinical decision support software and an extended operational interaction classification system (Zurich Interaction System) (2011) (17)
- Renal Reabsorption of Folates: Pharmacological and Toxicological Snapshots (2019) (16)
- Fire Eater's Lung: Retrospective Analysis of 123 Cases Reported to a National Poison Center (2013) (16)
- ABC transporter regulation by bile acids: where PXR meets FXR. (2003) (15)
- Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions (2017) (15)
- Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury (2018) (15)
- Evaluation of medication safety in the discharge medication of 509 surgical inpatients using electronic prescription support software and an extended operational interaction classification (2011) (15)
- Effect of ABCB1 Genotype on Pre- and Post-Cardiac Transplantation Plasma Lipid Concentrations (2011) (15)
- Fluorocholine Transport Mediated by the Organic Cation Transporter 2 (OCT2, SLC22A2): Implication for Imaging of Kidney Tumors (2018) (15)
- Bile Acid Sequestration by Cholestyramine Mitigates FGFR4 Inhibition-Induced ALT Elevation (2018) (15)
- Farnesoid X receptor activation induces the degradation of hepatotoxic 1‐deoxysphingolipids in non‐alcoholic fatty liver disease (2019) (14)
- The Role of Mitochondria in Drug-Induced Kidney Injury (2020) (14)
- Obeticholic Acid Ameliorates Valproic Acid–Induced Hepatic Steatosis and Oxidative Stress (2020) (14)
- Roflumilast--a phosphodiesterase-4 inhibitor licensed for add-on therapy in severe COPD. (2012) (14)
- Drug information for patients—an update of long‐term results: type of enquiries and patient characteristics (2009) (14)
- Comparative Performance of Two Drug Interaction Screening Programmes Analysing a Cross-Sectional Prescription Dataset of 84,625 Psychiatric Inpatients (2013) (14)
- Detection of the Arg702Trp, Gly908Arg and Leu1007fsinsC polymorphisms of the NOD2/CARD15 gene by real-time PCR with melting curve analysis (2004) (14)
- Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery (2017) (12)
- Tegaserod Inhibits the Serotonin Transporter SERT (2007) (12)
- Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling (2019) (12)
- Oral heroin in opioid-dependent patients: pharmacokinetic comparison of immediate and extended release tablets. (2009) (12)
- Plasma Membrane Cholesterol Regulates the Allosteric Binding of 1-Methyl-4-Phenylpyridinium to Organic Cation Transporter 2 (SLC22A2) (2020) (11)
- Drug-Induced Cholestatic Liver Disease (2013) (11)
- Hepatocellular transport proteins and their role in liver disease. (2001) (11)
- Effect of continuous venovenous hemodiafiltration on darunavir and raltegravir exposure after administration via a gastroduodenal tube. (2011) (11)
- Evaluating the Sensitivity and Specificity of Promising Circulating Biomarkers to Diagnose Liver Injury in Humans. (2021) (10)
- Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression. (2009) (10)
- Validation of a transparent decision model to rate drug interactions (2012) (10)
- Opposing Effects of Reduced Kidney Mass on Liver and Skeletal Muscle Insulin Sensitivity in Obese Mice (2014) (10)
- Performance of different data sources in identifying adverse drug events in hospitalized patients (2011) (9)
- Inhibition of hepatitis C virus RNA translation by antisense bile acid conjugated phosphorothioate modified oligodeoxynucleotides (ODN). (2013) (9)
- Deoxycholic acid is not related to lithogenic factors in gallbladder bile. (1999) (9)
- Evaluating the cost-effectiveness of early compared to late or no biologic treatment to manage Crohn's disease using real world data. (2019) (9)
- No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers (2016) (9)
- Moderate toxic effects following acute zonisamide overdose (2011) (9)
- Statin-associated immune-mediated necrotizing myopathy: a retrospective analysis of individual case safety reports from VigiBase (2018) (8)
- Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals. (2019) (8)
- The SLCO 1 A 2 Gene , Encoding Human Organic Anion-Transporting Polypeptide 1 A 2 , Is Transactivated by the Vitamin D Receptor (2012) (8)
- A new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry (2022) (8)
- Prediction of health care expenditure increase: how does pharmacotherapy contribute? (2019) (7)
- HLA-A*33:01 is strongly associated with drug-induced liver injury (DILI) due to terbinafine and several other unrelated compounds (2015) (7)
- Oxidative stress increases 1-deoxysphingolipid levels in chronic kidney disease. (2021) (7)
- The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course (2012) (7)
- Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management (2021) (7)
- Electrophoretic analysis of proteins in bile (1999) (7)
- Analysis of Drug-Drug Interactions in Swiss Claims Data Using Tizanidine and Ciprofloxacin as a Prototypical Contraindicated Combination (2018) (7)
- Hepatocyte nuclear factor-4 (cid:1) and bile acids regulate human concentrative nucleoside transporter-1 gene expression (2009) (6)
- microRNA‐206 modulates the hepatic expression of the organic anion‐transporting polypeptide 1B1 (2019) (6)
- Effective Opiate-Receptor Antagonist Therapy of Cholestatic Pruritus Induced by an Oral Contraceptive (2005) (6)
- Organic anion transporting polypeptides, cholestasis, and nuclear receptors (2002) (6)
- Comparative evaluation of the drug interaction screening programs MediQ and ID PHARMA CHECK in neurological inpatients (2012) (6)
- Untargeted Metabolomics Reveals Anaerobic Glycolysis as a Novel Target of the Hepatotoxic Antidepressant Nefazodone (2020) (5)
- [5-0xoproline (pyroglutamic acid) acidosis and acetaminophen- a differential diagnosis in high anion gap metabolic acidosis]. (2015) (5)
- Renal Glycosuria as a Novel Early Sign of Colistin-Induced Kidney Damage in Mice (2019) (5)
- Drug-induced liver injury (DILI) (2012) (5)
- [Nalmefene and Opioid Withdrawal Syndrome: Analysis of the Global Pharmacovigilance Database for Adverse Drug Reactions]. (2015) (5)
- UEG Week 2016 Poster Presentations (2016) (4)
- Phynx: an open source software solution supporting data management and web‐based patient‐level data review for drug safety studies in the general practice research database and other health care databases (2010) (4)
- Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning. (2013) (4)
- Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review (2021) (4)
- Cholesterol stimulates the cellular uptake of L-carnitine by the carnitine/organic cation transporter novel 2 (OCTN2) (2020) (4)
- Lower Risk of B1-to-pB3-Stage Migration in Crohn’s Disease Upon Immunosuppressive and Anti-TNF Treatment in the Swiss IBD Cohort Study (2019) (4)
- The Role of the Carnitine/Organic Cation Transporter Novel 2 in the Clinical Outcome of Patients With Locally Advanced Esophageal Carcinoma Treated With Oxaliplatin (2021) (4)
- Kounis syndrome: A retrospective analysis of individual case safety reports from the international WHO database in pharmacovigilance . (2019) (3)
- Faculty Opinions recommendation of Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. (2015) (3)
- hepatic MRP2 up-regulation during hepatitis C virus gene expression (2006) (3)
- Determination of the Single Nucleotide Polymorphisms C3435 and G2677T in MDR1 and C421A in BCRP in Blood Samples of Patients with Inflammatory Bowel Disease and Healthy Controls in the Swiss Population (2012) (3)
- PP232—Acute toxicity profile of pipamperone in overdose: A consecutive case series (2013) (3)
- [A 78-year-old female patient with dizziness, apraxia and seizure under proton pump inhibitor therapy]. (2014) (3)
- Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa (2021) (3)
- The role of cholesterol recognition (CARC/CRAC) mirror codes in the allosterism of the human organic cation transporter 2 (OCT2, SLC22A2). (2021) (3)
- Anti-Inflammatory Properties of High Density Lipoprotein (HDL) on Intestinal Epithelial Cells (2011) (3)
- Drug-induced liver injury in Switzerland: an analysis of drug-related hepatic disorders in the WHO pharmacovigilance database VigiBase from 2010 to 2020. (2021) (3)
- Analysis of Risk Factors for Low Bone Mineral Density in Infl ammatory Bowel Disease (2009) (3)
- Other clinical studyLong-term effects of cholecystectomy on bile acid metabolism☆☆☆ (1995) (3)
- 743 BSEP and MDR3 sequence diversity and haplotype structure in primary sclerosing cholangitis and primary biliary cirrhosis (2003) (3)
- Effects of proinflammatory cytokines on the regulation of rat hepatic organic anion transporters during toxic liver injury and cholestasis (2003) (3)
- Role of Membrane Transport in Hepatotoxicity and Pathogenesis of Drug-Induced Cholestasis (2013) (2)
- Coprescription of Levodopa with Antipsychotics in a Population of 84 596 Psychiatric Inpatients from 1994 to 2008 (2011) (2)
- Quanti fi cation of multiple bile acids in uninephrectomized rats using ultra-performance liquid chromatography-tandem mass spectrometry † (2013) (2)
- Concomitant administration of rifampicin and oxcarbazepine results in a significant decrease of the active MHD metabolite of oxcarbazepine (2016) (2)
- Medication as a risk factor for hospitalization due to heart failure and shock: a series of case-crossover studies in Swiss claims data (2020) (2)
- Sa1886 Bilberry Ingestion Improves Disease Activity in Mild to Moderate Ulcerative Colitis - an Open Pilot Study (2012) (2)
- Bile Acid Transporters (2006) (2)
- Too frequent low-dose methotrexate prescriptions: multicentre quality control and quality assurance with pre- and post-analysis. (2015) (2)
- Cost-effectiveness of cadaveric (C-OLT) and living-related liver transplantation (L-OLT): a modeling approach (2001) (2)
- Severe reduction in tacrolimus concentrations with concomitant metamizole (dipyrone) therapy in transplant patients (2019) (2)
- Severe injection site reactions after subcutaneous administration of Sayana®: a retrospective, post-marketing analysis of WHO and Swiss spontaneous pharmacovigilance reports (2017) (1)
- Validation of a transparent decision model to rate drug interactions (2012) (1)
- Pharmacovigilance in ophthalmology in Switzerland: an analysis of the most frequently reported ocular adverse drug reactions within the last 25 years. (2019) (1)
- Safety differentiation: emerging competitive edge in drug development. (2019) (1)
- Faculty Opinions recommendation of Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. (2015) (1)
- Plasma Sphingoid Base Profiles of Patients Diagnosed with Intrinsic or Idiosyncratic Drug-induced Liver Injury (2023) (1)
- 349 BILE ACIDS DOWNREGULATE THE HUMAN HEPATIC ORGANIC ANION TRANSPORTER 7 (2012) (1)
- Drug Interactions in the Liver (2020) (1)
- Severe injection site reactions after subcutaneous administration of Sayana©. (2017) (1)
- [Role of nuclear receptors in hepatic and intestinal drug transport]. (2003) (1)
- Association of a common vitamin D-binding protein ( DBP ) polymorphism with inflammatory bowel disease Running Head : DBP SNP and IBD (2011) (1)
- [Thrombocyte aggregation inhibitors: what are the risks?]. (2013) (1)
- The Role of NF-kB in the Downregulation of Organic Cation Transporter 2 Expression and Renal Cation Secretion in Kidney Disease (2022) (1)
- [6-year experience with a drug information service for patients]. (2009) (1)
- W1592 Vitamin D3 and Its Nuclear Receptor VDR Regulate the Expression and Activity of the Human Intestinal Proton-Coupled Folate Transporter PCFT (2009) (1)
- Bile acids downregulate the human hepatic organic anion transporter 7 (2012) (1)
- Letter to the editor by Drs. Gatti and Bertazzoli entitled “Evaluation of isolated case reports on hepatotoxicity” (2002) (1)
- The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity (2022) (1)
- Medication wrong route administration: a poisons center-based study (2013) (1)
- Cloning and functional characterization of a human liver basolateral organic anion transporting polypeptide (OATP) (1994) (1)
- Microrna Dependent Regulation of The Hepatic Uptake Transporter Oatp1b3 - The Role Of Mir-509 And Mir-656-3p (2015) (1)
- Pharmacokinetics of high doses of intramuscular and oral heroin in narcotic addicts (2004) (1)
- Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations (2013) (0)
- In memoriam Peter Meier-Abt 1947 -2021 (2021) (0)
- Falk Symposium 156: Genetics in Liver Disease Pharmacogenetics (2018) (0)
- Faculty Opinions recommendation of Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury. (2015) (0)
- 5919Sirtuin 5 deletion confers cerebral protection by attenuating blood brain barrier disruption in mice following middle cerebral artery occlusion (2017) (0)
- 461 Transcriptional regulation of the human, mouse and rat NTCP/NTCP genes: role of liver enriched transcription factors (2003) (0)
- 1.3 Pharmakodynamik (2012) (0)
- 12.4 Tranquillizer/Hypnotika (2012) (0)
- Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2) (2023) (0)
- Comparative evaluation of three clinical decision support systems: prospective screening for medication errors in 100 medical inpatients (2012) (0)
- BSEP and MDR3 sequence diversity and haplotype structure in primary sclerosing cholangitis, primary biliary cirrhosis and intrahepatic cholestasis of pregnancy (2004) (0)
- A VARIANT IN THE TRPA1 NOCICEPTIVE RECEPTOR CONTRIBUTES TO THE DEVELOPMENT OF PATHOLOGICAL PAIN SENSATION (2011) (0)
- Statin-associated immune-mediated necrotizing myopathy: a retrospective analysis of individual case safety reports from VigiBase (2018) (0)
- PP050—Saliva-based cyp1a2 phenotyping using caffeine from beverages: A practical course for students (2013) (0)
- [26-year-old patient with epigastric pain and cholestasis. Primary sclerosing cholangitis]. (1998) (0)
- Corrigendum to 'Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury' [Int. J. Cardiol. 260 (2018) 148-155]. (2018) (0)
- State-of-the-Art Lecture I: Pharmacogenetics (2007) (0)
- Title : Association of Liver Injury From Specific Drugs , or Groups of Drugs , With Polymorphisms in HLA and Other Genes in a Genome-wide Association Study (2016) (0)
- Pharmakovigilance: Von «primum non nocere» zu «qua nocent docent» (2017) (0)
- Contents Vol. 123, 2012 (2013) (0)
- Enterohepatic bile acid transporters and transcriptional control of their expression (2017) (0)
- Transporters in the Liver (2015) (0)
- Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa (2021) (0)
- M1804 The FC Fragment of Infliximab Modulates its Inhibitory Activity in Fibroblasts and Monocytes via Interaction With FC Receptors (2010) (0)
- Interaction of Local Anesthetics with Hepatocellular Organic Anion Transporting Polypeptides (2019) (0)
- Increased expression of hepatocyte nuclear factor 3β (HNF3β) in hepatocellular carcinoma is associated with repression of the human organic anion transporting polypeptide 8 (OATP8) gene (2003) (0)
- Faculty Opinions recommendation of Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome. (2015) (0)
- Concomitant administration of rifampicin and oxcarbazepine results in a significant decrease of the active MHD metabolite of oxcarbazepine (2015) (0)
- Eastern Cooperative Oncology Group Scale--Mobile App (2017) (0)
- 13.5 Antimalariamittel (2012) (0)
- Chenodeoxycholic acid induced changes in the expression of microRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes (2015) (0)
- Faculty Opinions recommendation of A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. (2015) (0)
- Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes. (2022) (0)
- 980 Inhibition of hepatitis C virus RNA translation with antisense taurocholate conjugated phosphorothioate modified oligodeoxynucleotides (ODN) in cell culture (2003) (0)
- 458 The human organic anion transporting polypeptide 8 gene (OATP8) is transactivated by the xenobiotics rifampicin and phenobarbital through an FXR-mediated mechanism (2003) (0)
- P2494Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in ischemia/reperfusion-induced cerebral injury (2018) (0)
- Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease (2012) (0)
- [Gastro-highlights 2004]. (2005) (0)
- The personality traits activity, self-reproach, and negative affect jointly predict clinical recurrence, depressive symptoms, and low quality of life in inflammatory bowel disease patients (2022) (0)
- Micro Rna-Dependent Regulation of The Farnesoid X Receptor (2015) (0)
- [Highlights in gastroenterology 2006]. (2006) (0)
- [Highlights in gastroenterology 2004]. (2005) (0)
- Improving hospital drug safety Identification of medication errors and subsequent development , implementation and outcome evaluation of alert algorithms for their targeted prevention (2016) (0)
- Comparative performance of two drug interaction screening programs analyzing a cross-sectional prescription dataset of 84,625 psychiatric inpatients (2012) (0)
- No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers (2016) (0)
- [Interactions with antiretroviral drugs]. (2010) (0)
- Tu1887 The Gene Encoding the G Protein-Coupled Receptor 68 (GPR68/ OGR1) is Regulated by TNF, Hypoxia, and Low pH in Human Monocytic Cells (2012) (0)
- Pharmacovigilance: du «primum non nocere» au «qua nocent docent» (2017) (0)
- Faculty Opinions recommendation of Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury. (2015) (0)
- Nuclear receptor regulation of bile acid transporters (2009) (0)
- Regulation of the Gene Encoding the Intestinal Bile Acid Transporter ASBT by CDX Transcription Factors (2011) (0)
- PP278—Bile acid induced changes in the expression of mirnas and genes involved in drug metabolism and disposition (2013) (0)
- 753 Sequence analysis of BSEP and MDR3 in patients with intrahepatic cholestasis of pregnancy (2003) (0)
- Faculty Opinions recommendation of Evolution of the Food and Drug Administration approach to liver safety assessment for new drugs: current status and challenges. (2015) (0)
- The FC Fragment of Infliximab Inhibits Its Activity in Intestinal Fibroblasts and Monocytes via High Affinity IgG Receptor CD64 (2011) (0)
- Regulation of hepatic and intestinal bile acid transport by FXR-controlled pathways (2007) (0)
- Severe reduction in tacrolimus concentrations with concomitant metamizole (dipyrone) therapy in transplant patients (2019) (0)
- Effect of obesity on the expression of the organic anion transporting polypeptide Oatp1a1 in mouse liver (2019) (0)
- Anti-infective therapy in special patient populations based on therapeutic drug monitoring (2018) (0)
- Do clinical and laboratory parameters predict thiopurine metabolism and clinical outcome in patients with inflammatory bowel diseases? (2019) (0)
- Medication as a risk factor for hospitalization due to heart failure and shock: a series of case-crossover studies in Swiss claims data (2020) (0)
- MicroRNA-192 regulates the expression of the farnesoid X receptor (2015) (0)
- Hepatocyte nuclear factor-4{alpha} and bile acids regulate human concentrative nucleoside transporter-1 gene expression (2009) (0)
- PP234—Intoxication with atypical antipsychotics in young children: A multicentre analysis of poisons centres data (2013) (0)
- Faculty of 1000 evaluation for Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives. (2015) (0)
- Faculty Opinions recommendation of Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts. (2015) (0)
- Human hepatic organic anion transporter 7 is negatively regulated by hepatocyte growth factor (2011) (0)
- Aspekte des Eisentherapie-Managements (2018) (0)
- M1722 Changes in mRNA Expression Levels of ASBT, SERT, and Octn2 in Crohn's Disease Patients (2008) (0)
- Tu1351 Functional Consequences of G Protein-Coupled Receptor 68 (GPR68/OGR1) Overexpression in Intestinal Epithelial Cells (2012) (0)
- Cellular and molecular mechanisms of colistin-induced nephrotoxicity (2019) (0)
- Bile salt Export Pump BSEP (ABCB11): Role in liver physiology and liver disease (2013) (0)
- Clinical Practice Guidelines EASL Clinical Practice Guidelines : Drug-induced liver injury q European Association for the Study of the Liver ⇑ Summary (2019) (0)
- Do clinical and laboratory parameters predict thiopurine metabolism and clinical outcome in patients with inflammatory bowel diseases? (2019) (0)
- The Extended Clearance Model (2021) (0)
- Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage (2017) (0)
- Corrigendum to "The role of cholesterol recognition (CARC/CRAC) mirror codes in the allosterism of the human organic cation transporter 2 (OCT2, SLC22A2)" [Biochem. Pharmacol. 194 (2021) 114840]. (2022) (0)
- 1.4 Pharmakogenetik (2012) (0)
- Expression of Proton-Sensing G Protein-Coupled Receptor 68 (ogr1) Is Increased by Tnf-Mediated Inflammatory Signalling (2011) (0)
- Pharmacogenetics of nuclear receptors and drug transporters in inflammatory bowel disease and hepatic drug metabolism (2017) (0)
- Intestinal absorption and drug levels (2018) (0)
- [Management of ulcerative colitis]. (2003) (0)
- Su1680 Effect of Chronic Renal Failure on the Hepatic Expression of Bile Acid Transporters (2013) (0)
- Functional characterization of MDR3 promoter mutations detected in intrahepatic cholestasis of pregnancy (2004) (0)
- University of Dundee Association of Liver Injury From Specific Drugs , or Groups of Drugs , With Polymorphisms in HLA and Other Genes in a Genome-wide Association Study (0)
- Canalicular microdomains and bile formation (2009) (0)
- Tu1836 Hypoxia Positively Regulates the Expression of the pH-Sensing G-Protein Coupled Receptor OGR-1 (2016) (0)
- Expression of the G Protein-Coupled Receptor 68 is Increased by TNF-Mediated Inflammatory Signalling (2011) (0)
- Inhibition der Hepatitis C-Virustranslation durch Gallensäure-gekoppelte antisense Oligodeoxynukleotide (2004) (0)
- Tu1821 The Gene Encoding the Human Organic Anion Transporting Polypeptide Oatp1a2 (Gene Symbol Slco1a2) is Transactivated by the Vitamin D Receptor (VDR) (2012) (0)
- Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant pathway (2023) (0)
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