Gert Vriend
#130,732
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Dutch biologist
Gert Vriend's AcademicInfluence.com Rankings
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Biology
#8608
World Rank
#11711
Historical Rank
Molecular Biology
#1103
World Rank
#1128
Historical Rank
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Biology
Gert Vriend's Degrees
- PhD Biophysics University of Groningen
- Masters Chemistry University of Groningen
Why Is Gert Vriend Influential?
(Suggest an Edit or Addition)Gert Vriend's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- WHAT IF: a molecular modeling and drug design program. (1990) (3504)
- Errors in protein structures (1996) (2085)
- Increasing the precision of comparative models with YASARA NOVA—a self‐parameterizing force field (2002) (1359)
- YASARA View—molecular graphics for all devices—from smartphones to workstations (2014) (980)
- A series of PDB related databases for everyday needs (2010) (877)
- Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces (2010) (795)
- Making optimal use of empirical energy functions: Force‐field parameterization in crystal space (2004) (787)
- GPCRDB information system for G protein-coupled receptors (2003) (784)
- Heterozygous Germline Mutations in the p53 Homolog p63 Are the Cause of EEC Syndrome (1999) (708)
- Human dectin-1 deficiency and mucocutaneous fungal infections. (2009) (698)
- A text-mining analysis of the human phenome (2006) (609)
- Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis (2011) (606)
- New ways to boost molecular dynamics simulations (2015) (594)
- A series of PDB-related databanks for everyday needs (2014) (581)
- PredictProtein—an open resource for online prediction of protein structural and functional features (2014) (551)
- PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules (1996) (548)
- Conserved Role of a Complement-like Protein in Phagocytosis Revealed by dsRNA Knockout in Cultured Cells of the Mosquito, Anopheles gambiae (2001) (529)
- Rational engineering of enzyme stability. (2004) (430)
- A New Generation of Crystallographic Validation Tools for the Protein Data Bank (2011) (390)
- GPCRdb: an information system for G protein-coupled receptors (2015) (339)
- Homology modeling, model and software evaluation: three related resources (1998) (339)
- Fast empirical pKa prediction by Ewald summation. (2006) (326)
- Homology modeling. (2020) (247)
- Costs and benefits of processivity in enzymatic degradation of recalcitrant polysaccharides (2006) (244)
- Objectively judging the quality of a protein structure from a Ramachandran plot (1997) (230)
- A database of protein structure families with common folding motifs (1992) (224)
- Identification of Different Binding Sites in the Dendritic Cell-specific Receptor DC-SIGN for Intercellular Adhesion Molecule 3 and HIV-1* (2002) (199)
- WeNMR: Structural Biology on the Grid (2011) (189)
- Amyloids protect the silkmoth oocyte and embryo (2000) (188)
- PDB_REDO: automated re-refinement of X-ray structure models in the PDB (2009) (183)
- Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems (2001) (180)
- Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase. (2004) (179)
- Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs. (2006) (178)
- GPCRdb: the G protein‐coupled receptor database – an introduction (2016) (163)
- Dominant missense mutations in ABCC9 cause Cantú syndrome (2012) (161)
- Extreme Stabilization of a Thermolysin-like Protease by an Engineered Disulfide Bond* (1997) (161)
- The use of position‐specific rotamers in model building by homology (1995) (156)
- WIWS: a protein structure bioinformatics Web service collection (2010) (150)
- 3DM: Systematic analysis of heterogeneous superfamily data to discover protein functionalities (2010) (149)
- Molecular docking using surface complementarity (1996) (148)
- The PDBFINDER database: a summary of PDB, DSSP and HSSP information with added value (1996) (143)
- A common motif in G-protein-coupled seven transmembrane helix receptors (1993) (141)
- A common step for signal transduction in G protein-coupled receptors. (1994) (141)
- CING: an integrated residue-based structure validation program suite (2012) (132)
- Isolation of Llama Antibody Fragments for Prevention of Dandruff by Phage Display in Shampoo (2005) (126)
- Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis (2018) (122)
- Models@Home: distributed computing in bioinformatics using a screensaver based approach (2002) (122)
- Tools and data services registry: a community effort to document bioinformatics resources (2015) (120)
- Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance (2014) (118)
- Improving macromolecular electrostatics calculations. (1999) (114)
- Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal-recessive nonsyndromic hearing impairment DFNB35. (2008) (108)
- GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases (2005) (108)
- DRESS: a database of REfined solution NMR structures (2004) (103)
- Automatic rebuilding and optimization of crystallographic structures in the Protein Data Bank (2011) (91)
- Molden 2.0: quantum chemistry meets proteins (2017) (91)
- Traditional Biomolecular Structure Determination by NMR Spectroscopy Allows for Major Errors (2005) (90)
- Exploring Protein Dynamics Space: The Dynasome as the Missing Link between Protein Structure and Function (2012) (89)
- Structural determinants of the stability of thermolysin-like proteinases (1995) (86)
- Correlated Mutation Analyses on Very Large Sequence Families (2002) (83)
- GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base (2010) (82)
- Validation of protein structures derived by NMR spectroscopy (2004) (82)
- Correlated mutation analyses on super‐family alignments reveal functionally important residues (2009) (82)
- Quantitative evaluation of experimental NMR restraints. (2003) (82)
- The precision of NMR structure ensembles revisited (2003) (79)
- A low resolution model for the interaction of G proteins with G protein-coupled receptors. (1999) (78)
- Induced refolding of a temperature denatured llama heavy‐chain antibody fragment by its antigen (2005) (73)
- Prediction of protein residue contacts with a PDB-derived likelihood matrix. (2002) (71)
- Prediction and analysis of structure, stability and unfolding of thermolysin-like proteases (1993) (68)
- GPCRDB: information system for G protein-coupled receptors (2010) (65)
- Re-refinement from deposited X-ray data can deliver improved models for most PDB entries (2009) (63)
- Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding (2008) (61)
- Homology modelling and spectroscopy, a never-ending love story (2009) (60)
- Toward a Consensus Model of the hERG Potassium Channel (2010) (60)
- The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation. (2012) (56)
- GRIS: glycoprotein-hormone receptor information system. (2006) (56)
- Discovery of Small Molecule CD40-TRAF6 Inhibitors (2015) (54)
- Potential ligand-binding residues in rat olfactory receptors identified by correlated mutation analysis. (1995) (53)
- The Effects of Modifying the Surface Charge on the Catalytic Activity of a Thermolysin-like Protease* (2002) (51)
- Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase. (1994) (51)
- The EMBRACE web service collection (2010) (50)
- Correcting ligands, metabolites, and pathways (2006) (49)
- The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family. (1995) (49)
- Integrins of Anopheles gambiae and a putative role of a new beta integrin, BINT2, in phagocytosis of E. coli. (2006) (49)
- Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base (2007) (48)
- The interaction of class B G protein-coupled receptors with their hormones. (1998) (48)
- PDB Improvement Starts with Data Deposition (2007) (47)
- MRS: a fast and compact retrieval system for biological data (2005) (45)
- Stabilization of peptide fibrils by hydrophobic interaction. (2007) (43)
- GPCRdb: an information system for G protein-coupled receptors (2016) (43)
- iPPI-DB: an online database of modulators of protein–protein interactions (2015) (42)
- NRG-CING: integrated validation reports of remediated experimental biomolecular NMR data and coordinates in wwPDB (2011) (40)
- A sequence and structural study of transmembrane helices (2001) (39)
- An active registry for bioinformatics web services (2009) (38)
- Stabilization of a chitinase from Serratia marcescens by Gly-->Ala and Xxx-->Pro mutations. (2003) (38)
- GPCRDB: an information system for G protein-coupled receptors. (1998) (38)
- Tracing evolutionary pressure (2008) (37)
- The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model (2016) (36)
- Alpha-Bulges in G Protein-Coupled Receptors (2014) (36)
- SNP Linkage Analysis and Whole Exome Sequencing Identify a Novel POU4F3 Mutation in Autosomal Dominant Late-Onset Nonsyndromic Hearing Loss (DFNA15) (2013) (35)
- Amyloid‐like fibrils from an 18‐residue peptide analogue of a part of the central domain of the B‐family of silkmoth chorion proteins (2001) (35)
- Stabilization of protein-protein interaction complexes through small molecules. (2016) (34)
- Drug design for ever, from hype to hope (2012) (33)
- Clinical and molecular characterizations of novel POU3F4 mutations reveal that DFN3 is due to null function of POU3F4 protein. (2009) (32)
- Proteases and their inhibitors: today and tomorrow. (1991) (31)
- On the complexity of Engh and Huber refinement restraints: the angle τ as example (2010) (31)
- The mutations in FGFR2-associated craniosynostoses are clustered in five structural elements of immunoglobulin-like domain III of the receptor (1998) (30)
- The bio.tools registry of software tools and data resources for the life sciences (2019) (28)
- The NMR restraints grid at BMRB for 5,266 protein and nucleic acid PDB entries (2009) (28)
- New Biological Insights from Better Structure Models. (2016) (28)
- BDB: databank of PDB files with consistent B-factors. (2014) (28)
- Aggregation of population‐based genetic variation over protein domain homologues and its potential use in genetic diagnostics (2017) (26)
- GPCRDB: an information system for G protein-coupled receptors (2013) (25)
- Detection of trans–cis flips and peptide-plane flips in protein structures (2015) (24)
- Identification of class-determining residues in G protein-coupled receptors by sequence analysis. (1997) (24)
- CASP2 molecular docking predictions with the LIGIN software (1997) (23)
- Conformational transitions accompanying oligomerization of yeast alcohol oxidase, a peroxisomal flavoenzyme. (1999) (23)
- Consensus engineering of sucrose phosphorylase: The outcome reflects the sequence input (2013) (23)
- NucleaRDB: information system for nuclear receptors (2011) (22)
- NRMD: Nuclear Receptor Mutation Database (2003) (21)
- Molecular characterization of an extracellular acid-resistant lipase produced by Rhizopus javanicus. (1993) (21)
- A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine (2014) (21)
- The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss (2014) (20)
- Systematic generation of in vivo G protein-coupled receptor mutants in the rat (2010) (19)
- KMAD: knowledge-based multiple sequence alignment for intrinsically disordered proteins (2015) (19)
- A novel COCH mutation associated with autosomal dominant nonsyndromic hearing loss disrupts the structural stability of the vWFA2 domain (2012) (19)
- 3D-e-Chem-VM: Structural Cheminformatics Research Infrastructure in a Freely Available Virtual Machine (2017) (19)
- Concepts and Tools for NMR Restraint Analysis and Validation (2004) (18)
- Validation and correction of Zn–CysxHisy complexes (2016) (18)
- A Molecular Switch Driving Inactivation in the Cardiac K+ Channel hERG (2012) (17)
- Interchain cysteine bridges control entry of progesterone to the central cavity of the uteroglobin dimer. (1992) (16)
- Molecular Determinants of the Interaction of Mad with the PAH2 Domain of mSin3* (2004) (16)
- Definition of a New Information-Based Per-Residue Quality Parameter (2005) (15)
- Key challenges for the creation and maintenance of specialist protein resources (2015) (15)
- Identification of residues essential for progesterone binding to uteroglobin by site-directed mutagenesis (1991) (15)
- The moonlighting function of pyruvate carboxylase resides in the non-catalytic end of the TIM barrel. (2010) (14)
- Integrating GPCR-specific information with full text articles (2011) (14)
- Progesterone binding to uteroglobin: two alternative orientations of the ligand. (1995) (12)
- In Silico Structure and Sequence Analysis of Bacterial Porins and Specific Diffusion Channels for Hydrophilic Molecules: Conservation, Multimericity and Multifunctionality (2016) (12)
- 3D‐e‐Chem: Structural Cheminformatics Workflows for Computer‐Aided Drug Discovery (2018) (11)
- Outer membrane phospholipase A’s roles in Helicobacter pylori acid adaptation (2017) (10)
- 3D-Fun: predicting enzyme function from structure (2008) (10)
- Visually impaired researchers get their hands on quantum chemistry: application to a computational study on the isomerization of a sterol (2014) (10)
- G protein-coupled receptors of class A harness the energy of membrane potential to increase their sensitivity and selectivity. (2019) (9)
- NewProt – a protein engineering portal (2017) (9)
- Batch mode generation of residue-based diagrams of proteins (2003) (9)
- CorNet: Assigning function to networks of co-evolving residues by automated literature mining (2017) (8)
- Trypsin sensitivity of several human rhinovirus serotypes in their low pH-induced conformation. (1989) (8)
- AsteriX: A Web Server To Automatically Extract Ligand Coordinates from Figures in PDF Articles (2012) (8)
- Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat (2015) (8)
- NRSAS: Nuclear Receptor Structure Analysis Servers (2003) (8)
- Negative Constraints Underlie the ErbB Specificity of Epidermal Growth Factor-like Ligands* (2006) (5)
- Blind and Visually Impaired Students Can Perform Computer-Aided Molecular Design with an Assistive Molecular Fabricator (2015) (5)
- Loop modelling 1.0. (2018) (5)
- Clinical and molecular characterizations of novel POU 3 F 4 mutations reveal that DFN 3 is due to null function of POU 3 F 4 protein (2009) (4)
- Full window stereo. (1999) (4)
- Facilities that make the PDB data collection more powerful (2019) (4)
- Modeling GPCRs. (2006) (4)
- Improved coordinate reconstruction from stereo diagrams. (1996) (4)
- Status quo of annotation of human disease variants (2013) (4)
- Rendering One Autolysis Site in Bacillus Subtilis Neutral Protease Resistant to Cleavage Reveals a New Fission (1998) (4)
- Anomalies in the refinement of isoleucine (2014) (4)
- Forecasting residue‐residue contact prediction accuracy (2017) (4)
- The Future of Protein Secondary Structure Prediction Was Invented by Oleg Ptitsyn (2020) (3)
- On the specificity of carboxypeptidase N, a comparative study. (1993) (3)
- Correlated mutations select misfolded from properly folded proteins (2017) (3)
- A novel COCH mutation associated with autosomal dominant nonsyndromic hearing loss disrupts the structural stability of the vWFA2 domain (2012) (3)
- Automatic rebuilding and optimization of crystallographic structures in the PDB (2011) (3)
- The Dynasome as the Missing Link Between Protein Structure and Function (2012) (2)
- Accessing Scientific Applications through the WNoDeS Cloud Virtualization Framework (2014) (2)
- Detection oftrans–cisflips and peptide plane flips in protein structures (2015) (2)
- A Critical Note on Symmetry Contact Artifacts and the Evaluation of the Quality of Homology Models (2018) (2)
- Protein Structures: What Good Is Beauty If It Cannot Be Seen? (2003) (2)
- The Inverse Gamma Distribution and Benford's Law (2016) (2)
- Quantum chemical study of the isomerization of 24-methylenecycloartanol, a potential marker of olive oil refining (2015) (2)
- GPCRs: Past, present, and future (2010) (2)
- Status quo of annotation of human disease variants (2013) (1)
- Bio‐knowledge‐based filters improve residue‐residue contact prediction accuracy (2018) (1)
- Harvesting the information from a family of proteins (2008) (1)
- Correlated mutations distinguish misfolded and properly folded proteins (2017) (1)
- Erratum: Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 7 (2686-2691) DOI: 10.1073/pnas.1400419111) (2014) (1)
- a community effort to document bioinformatics resources (2015) (1)
- Protein Three-Dimensional Structure Validation (2007) (1)
- Molecular Determinants in K+ Channel hERG Inactivation Gating (2012) (1)
- The bio.tools registry of software tools and data resources for the life sciences (2019) (1)
- Molecular modeling of pharmaceutically important targets (1997) (1)
- The EMBRACE registry. (2008) (1)
- COST Action BM 1006 (SeqAhead): MC BUSINESS MEETING AND SCIENTIFIC MEETING (2012) (0)
- Comparative model building of plasma carboxypeptidase U (1994) (0)
- Information flux through proteins (2004) (0)
- SUPERSTABLE E65Q MUTANT OF LEISHMANIA MEXICANA TRIOSEPHOSPHATE ISOMERASE (TIM) (2000) (0)
- Genome wide copy number analysis and gene expression profiling of CHEK 2 * 1100 delC and BRCA 1 hereditary breast cancer (2008) (0)
- Entropy and Variability: A Second Opinion by Deep Learning (2022) (0)
- Fun : predicting enzyme function from structure (2017) (0)
- The role of the dopamine D 1 receptor in social cognition (2016) (0)
- GOBLET: achievements and goals a year on (2014) (0)
- Validation and correction of carbohydrate 3D structures (2008) (0)
- Comparative molecular modeling of the active subunit of human kininase I. (1992) (0)
- Abstract 611: Blocking CD40-TRAF6 Signaling is a Novel Therapeutic Target in Obesity-Associated Insulin Resistance (2014) (0)
- MCSIS heterogeneous data handling (2006) (0)
- Classification of peptide receptors by analysis of correlated mutations (1995) (0)
- Class A GPCRs use the membrane potential to increase their sensitivity and selectivity (2019) (0)
- The NewProt Self-Service Portal for Protein Engineering (2014) (0)
- University of Groningen Conformational transitions accompanying oligomerization of yeast alcohol oxidase, a peroxisomal flavoenzyme Boteva, (1999) (0)
- Invited Talk: Information Flux Through Proteins (2004) (0)
- 3D structure based multiple sequence alignments applied to rational enzyme design and DNA diagnostics. (2008) (0)
- NewProt 1.0 (2017) (0)
- Common Pitfalls and Novel Opportunities for Predicting Variant Pathogenicity (2016) (0)
- ECCB 2012 Organization (2012) (0)
- Molecular modelling and macromolecular visualisation with WHAT IF (1998) (0)
- Structure Ways & Means A New Generation of Crystallographic Validation Tools for the Protein Data Bank (0)
- MRS-file data structure (2011) (0)
- nar / gkn 308 3 D-Fun : predicting enzyme function from structure (2008) (0)
- Three-Dimensional Structure of a Llama VHH Domain OE7 binding the cell wall protein Malf1 (2005) (0)
- Class A GPCRs harness the energy of membrane potential to increase their sensitivity and selectivity (2020) (0)
- Structural anomalies in a published NMR-derived structure of IRAK-M. (2021) (0)
- Abstracts from the ninth annual meeting of the molecular graphics societyWhat if you want to superimpose proteins (1990) (0)
- Combinatorial algorithms in bioinformatics (2004) (0)
- University of Groningen Extreme stabilization of a thermolysin-like protease by an engineered disulfide bond Mansfeld, (1997) (0)
- CING: an integrated residue-based structure validation program suite (2012) (0)
- P.23-007-Mon Virtual high-throughput screening for identification of Plasmodium falciparum protein kinase CK2-alpha inhibitors through targeting the active, allosteric and subunit interface sites (0)
- Overview of GeneSeeker (2011) (0)
- THE INVERSE GAMMA DISTRIBUTION AND BENFORD ’ (2017) (0)
- New features and improvements in carbohydrate three-dimensional structure validation (2012) (0)
- Physicist's simple access to protein structures: the computer program WHAT IF (2001) (0)
- Combinatoriële algoritmen in de bioinformatica (2004) (0)
- Quantifying the deformability of malaria-infected red blood cells using deep learning trained on synthetic cells (2022) (0)
- Ten Simples Rules on How to Organise a Bioinformatics Hackathon (2021) (0)
- Cis-trans flips: peptide bond conformation correction (2015) (0)
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What Schools Are Affiliated With Gert Vriend?
Gert Vriend is affiliated with the following schools: