Gillian Griffiths

Gillian Griffiths's AcademicInfluence.com Rankings

Gillian Griffiths

Biology

#1645

World Rank

#2698

Historical Rank

Immunology

#348

World Rank

#361

Historical Rank

biology Degrees

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Biology

Gillian Griffiths's Degrees

PhD Immunology University of Oxford

Why Is Gillian Griffiths Influential?

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According to Wikipedia, Gillian Griffiths, FMedSci FRS is a British cell biologist and immunologist. Griffiths was one of the first to show that immune cells have specialised mechanisms of secretion, and identified proteins and mechanisms that control cytotoxic T lymphocyte secretion. Griffiths is Professor of Cell Biology and Immunology at the University of Cambridge and is the Director of the Cambridge Institute for Medical Research.

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Gillian Griffiths's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The immunological synapse of CTL contains a secretory domain and membrane bridges. (2001) (857)
Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton (2003) (714)
Secretory lysosomes (2002) (534)
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone (1984) (523)
Centrosome polarization delivers secretory granules to the immunological synapse (2006) (426)
Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes (2001) (412)
Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells (1999) (407)
Molecular events during maturation of the immune response to oxazolone (1985) (369)
Linking Albinism and Immunity: The Secrets of Secretory Lysosomes (2004) (359)
Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11. (2009) (358)
Secretory mechanisms in cell-mediated cytotoxicity. (2007) (296)
mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification (1983) (270)
Structural and kinetic basis for heightened immunogenicity of T cell vaccines (2005) (266)
Centrosome polarization delivers secretory granules to the immunological synapse (2006) (259)
Adaptor protein 3–dependent microtubule-mediated movement of lytic granules to the immunological synapse (2003) (247)
The biogenesis of lysosomes and lysosome-related organelles. (2014) (243)
Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse (2015) (234)
Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathway (1995) (229)
The immunological synapse: a focal point for endocytosis and exocytosis (2010) (225)
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation (2007) (224)
Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent. (1999) (221)
Delivering the kiss of death (2003) (219)
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid‐binding C2 domain (1997) (202)
Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I. (2000) (194)
Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor (1993) (187)
Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease. (2006) (179)
Regulated Secretion from Hemopoietic Cells (1999) (178)
Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells. (1991) (176)
Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis. (1995) (169)
Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail. (2001) (163)
A general role for Rab27a in secretory cells. (2003) (161)
The leaden Gene Product Is Required with Rab27a to Recruit Myosin Va to Melanosomes in Melanocytes (2002) (155)
The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse (2009) (154)
Lytic granules, secretory lysosomes and disease. (2003) (154)
Innate immunity defects in Hermansky-Pudlak type 2 syndrome. (2006) (145)
Regulating secretory lysosomes. (2006) (143)
CTL secretory lysosomes: biogenesis and secretion of a harmful organelle. (2005) (134)
An early history of T cell-mediated cytotoxicity (2018) (132)
Genotype–phenotype study of familial haemophagocytic lymphohistiocytosis due to perforin mutations (2007) (132)
Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome. (2016) (127)
Analysis of the Lysosomal Storage Disease Chediak–Higashi Syndrome (2000) (124)
Secretory lysosomes - a special mechanism of regulated secretion in haemopoietic cells. (1996) (121)
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation (2006) (120)
Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry (2016) (119)
The cell biology of CTL killing. (1995) (113)
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. (2012) (111)
Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse (2013) (108)
Anti-oxazolone hybridomas and the structure of the oxazolone idiotype. (1983) (106)
Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases (2010) (105)
The secretory synapse: the secrets of a serial killer (2002) (105)
Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease. (1998) (103)
A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin. (2005) (98)
The role of the cytoskeleton at the immunological synapse (2013) (98)
Origins of the cytolytic synapse (2016) (97)
Microtubule‐Dependent Transport of Secretory Vesicles in RBL‐2H3 Cells (2003) (97)
Centrosome docking at the immunological synapse is controlled by Lck signaling (2011) (94)
The synapse and cytolytic machinery of cytotoxic T cells. (2010) (92)
Slp1 and Slp2-a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse (2008) (89)
Secretory Lysosome Biogenesis in Cytotoxic T Lymphocytes from Normal and Chediak Higashi Syndrome Patients (2000) (89)
Familial Hemophagocytic Lymphohistiocytosis: When Rare Diseases Shed Light on Immune System Functioning (2014) (88)
Molecular basis of familial hemophagocytic lymphohistiocytosis (2010) (87)
Cell polarisation and the immunological synapse (2013) (86)
Perforin and granzyme A expression identifying cytolytic lymphocytes in rheumatoid arthritis. (1992) (86)
Granzyme A and perforin as markers for rejection in cardiac transplantation (1991) (84)
Novel Munc13–4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis (2006) (81)
Genotype–phenotype study of familial haemophagocytic lymphohistiocytosis type 3 (2011) (78)
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems (2011) (76)
The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2. (2013) (72)
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy (2020) (69)
Structure and biogenesis of lytic granules. (1995) (69)
Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes (2017) (67)
Syntaxin binding mechanism and disease-causing mutations in Munc18-2 (2013) (66)
The cytotoxic T lymphocyte immune synapse at a glance (2016) (64)
L is for lytic granules: lysosomes that kill. (1998) (62)
Communication, the centrosome and the immunological synapse (2014) (60)
Light chain germ‐line genes and the immune response to 2‐phenyloxazolone. (1985) (59)
Syntaxin 11 is required for NK and CD8+ T‐cell cytotoxicity and neutrophil degranulation (2013) (58)
T cell cytolytic capacity is independent of initial stimulation strength (2018) (57)
Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis (2015) (55)
STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5 (2010) (54)
The role of the secretory immunological synapse in killing by CD8+ CTL. (2003) (52)
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity (2019) (51)
Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1 (2010) (48)
A Role for Rab7 in the Movement of Secretory Granules in Cytotoxic T Lymphocytes (2011) (45)
PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes (2018) (44)
Ca2+ Release from the Endoplasmic Reticulum of NY-ESO-1–Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor (2010) (44)
Protein sorting and secretion during CTL killing. (1997) (42)
Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding (2015) (41)
Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3 (2008) (41)
Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity (2011) (40)
Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL (2014) (37)
What's special about secretory lysosomes? (2002) (37)
Rab 27 a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes ✪ (2001) (35)
Normal and abnormal secretion by haemopoietic cells (2001) (33)
Enhanced interaction of HLA-DM with HLA-DR in enlarged vacuoles of hereditary and infectious lysosomal diseases. (1999) (33)
Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs (2017) (29)
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation (2019) (28)
Endocytosing the death sentence (2003) (27)
Mitochondrial translation is required for sustained killing by cytotoxic T cells (2021) (26)
Munc18‐2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T‐Lymphocytes (2015) (24)
Sorting out the multiple roles of Fas ligand. (2000) (22)
Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse (2018) (22)
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency (2013) (20)
Pathways for Cytolysis (1995) (20)
Normal Lytic Granule Secretion by Cytotoxic T Lymphocytes Deficient in BLOC‐1, ‐2 and ‐3 and Myosins Va, VIIa and XV (2005) (20)
THE USE OF GRANZYME A AS A MARKER OF HEART TRANSPLANT REJECTION IN CYCLOSPORINE OR ANTI‐CD4 MONOCLONAL ANTIBODY‐TREATED RATS (1993) (18)
Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling (2020) (15)
Cytotoxic T lymphocyte effector function is independent of nucleus–centrosome dissociation (2012) (15)
Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis. (2014) (15)
A General Role for Rab 27 a in Secretory Cells (2003) (14)
Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse (2019) (14)
Albinism and immunity: what's the link? (2002) (14)
The Analysis of Structural Diversity in the Antibody Response (1985) (14)
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity. (2019) (13)
Teasing out function from morphology: Similarities between primary cilia and immune synapses (2021) (13)
Gaucher Disease: Forging a New Path to the Lysosome (2007) (12)
Signal strength controls the rate of polarization within CTLs during killing (2021) (11)
Cytoskeletal control of the secretory immune synapse. (2021) (10)
Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement (2020) (10)
Secretion from Myeloid Cells: Secretory Lysosomes. (2016) (10)
Open questions: missing pieces from the immunological jigsaw puzzle (2013) (7)
T cell cytolytic capacity is independent of initial stimulation strength (2018) (6)
The risk of hemophagocytic lymphohistiocytosis in Hermansky (2016) (4)
Staggered starts in the race to T cell activation (2021) (4)
mRNA sequences define an unusually restricted IgG response to oxazolone. (1984) (3)
Membranes and organelles (Editorial overview) (2004) (2)
A new direction for Traffic (2020) (2)
The Granzyme A Gene: A Marker for Cytolytic Lymphocytes In Vivo (1993) (2)
Methods for detecting lytic granules in natural killer cells. (2000) (1)
Imaging the Effector CD8 Synapse. (2017) (1)
JB Minireview—Membrane Traffic in Physiology and Pathology Regulating Secretory Lysosomes (2006) (1)
Novel Munc13-4 Mutations in Patients with Hemophagocytic Lymphohistiocytosis. (2005) (1)
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity. (2022) (1)
Dynamic modulation of cortical actin at the immunological synapse controls lytic granule secretion in cytotoxic T lymphocytes (2017) (0)
HLA-DR in Enlarged Vacuoles of Hereditary Enhanced Interaction of HLA-DM with (1998) (0)
Immunology Select (2006) (0)
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation (2019) (0)
Author response: Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling (2020) (0)
Defective CD107a Surface Expression Heralds Munc13-4 Defect and Discriminates between Genetic Subtypes of Familial Hemophagocytic Lymphohistiocytosis (FHL). (2006) (0)
Super‐killer CTLs are generated by single gene deletion of Bach2 (2022) (0)
Dideoxy mRNA Sequencing as a Method to Analyze Antibody Diversity (1985) (0)
Faculty Opinions recommendation of Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity. (2002) (0)
Homozygous Deletion in Stxbp2 Causative of Familial Hemophagocytic Lymphohistiocytosis Type 5 (Fhl-5) (2015) (0)
Messenger rna sequences define an unusually restricted immuno globulin g response to oxazolone (1984) (0)
Actin Depletion Initiates E vents Leading to Granule Secretion at the Immunological Synapse Graphical (2015) (0)
Imaging the T-cell receptor: new approaches, new insights. (2023) (0)
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy (2023) (0)
Defective CD 107 a surface expression heralds Munc 13-4 defect and discriminates between genetic subtypes of the disease . Running title : NK cells and CD 107 a expression in FHL (2006) (0)
Detection of Specific mRNAs by In Situ Hybridization (1993) (0)
REDUCED TYPE I INTERFERON PRODUCTION BY DENDRITIC CELLS AND WEAKENED ANTIVIRAL IMMUNITY IN WISKOTT-ALDRICH SYNDROME PROTEIN DEFICIENCY (2012) (0)
Gillian Griffiths: how T cells get on target. Interview by Caitlin Sedwick. (2013) (0)
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy (2020) (0)
Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity (2011) (0)
The role of Adaptor Protein 3 in cytotoxic T lymphocytes (2009) (0)
Functional characterisation of Munc18–2 missense mutations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) (2010) (0)
An early history of T cell-mediated cytotoxicity (2018) (0)
Mini-Review Regulated Secretion from Hemopoietic Cells (1999) (0)
Open questions: missing pieces from the immunological jigsaw puzzle (2013) (0)
Comment Endocytosing the death sentence (2003) (0)
Is Temperature Dependent Peptide-MHC Class I Tetrameric Complexes Specificity of CTL Interactions with (1999) (0)
can impair processing to the active form of perforin A single amino acid change, A91V, leads to conformational changes that (2013) (0)
Identification of a Deletion in Stxbp2 Causative of Familial Hemophagocytic Lymphohistiocytosis Type 5 (2015) (0)
Editorial Announcement (2006) (0)
Advisory Board and Contents (2021) (0)
Pigment Cells Mechanisms of Protein Delivery to Melanosomes in (2015) (0)
MUNC13–4 Mutations in Patients with Hemophagocytic Lymphohistiocytosis Are Scattered over the Functional Domains of the Protein. (2006) (0)
Advisory Board and Contents (2020) (0)
PIP 5 Kinases Regulate Me mbrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes Graphical (2018) (0)

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Gillian Griffiths's Academic­Influence.com Rankings