Giulio Superti-Furga
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Italian molecular and systems biologist
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Giulio Superti-Furgabiology Degrees
Biology
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#6442
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Systems Biology
#18
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#18
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Molecular Biology
#1243
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#1270
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Biology
Giulio Superti-Furga's Degrees
- PhD Molecular Biology University of Vienna
Why Is Giulio Superti-Furga Influential?
(Suggest an Edit or Addition)According to Wikipedia, Giulio Superti-Furga is an Italian molecular and systems biologist based in Vienna, Austria. He is the Scientific Director of CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , and Professor of Medical Systems Biology at the Medical University of Vienna.
Giulio Superti-Furga's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Functional organization of the yeast proteome by systematic analysis of protein complexes (2002) (4880)
- Proteome survey reveals modularity of the yeast cell machinery (2006) (2642)
- Somatic mutations of calreticulin in myeloproliferative neoplasms. (2013) (1693)
- The CRAPome: a Contaminant Repository for Affinity Purification Mass Spectrometry Data (2013) (1234)
- An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome (2009) (1026)
- Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase (2003) (782)
- Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity (2010) (718)
- Gene essentiality and synthetic lethality in haploid human cells (2015) (660)
- Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. (2007) (650)
- A physical and functional map of the human TNF-α/NF-κB signal transduction pathway (2004) (650)
- ELM server: a new resource for investigating short functional sites in modular eukaryotic proteins (2003) (635)
- The promise and peril of chemical probes. (2015) (623)
- SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1 (2014) (530)
- Target profiling of small molecules by chemical proteomics. (2009) (490)
- Regulation of the c-Abl and Bcr–Abl tyrosine kinases (2004) (482)
- Complement factor H binds malondialdehyde epitopes and protects from oxidative stress (2011) (479)
- Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death (2015) (473)
- Serine and tyrosine phosphorylations cooperate in Raf‐1, but not B‐Raf activation (1999) (457)
- IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA (2011) (430)
- Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling (1999) (427)
- A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (2004) (422)
- A Myristoyl/Phosphotyrosine Switch Regulates c-Abl (2003) (420)
- An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells (2006) (414)
- Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor–MAP kinase–fos signalling pathway (1997) (410)
- A Call for Systematic Research on Solute Carriers (2015) (388)
- Dynamic Coupling between the SH2 and SH3 Domains of c-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation (2001) (383)
- Structure-Based Assembly of Protein Complexes in Yeast (2004) (372)
- Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy (2014) (323)
- Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter (1987) (318)
- The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response (2008) (281)
- The minimum information required for reporting a molecular interaction experiment (MIMIx) (2007) (279)
- The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib (2007) (275)
- RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. (2004) (272)
- Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells (2009) (263)
- Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity (2017) (261)
- A chemical and phosphoproteomic characterization of dasatinib action in lung cancer (2010) (261)
- Csk inhibition of c‐Src activity requires both the SH2 and SH3 domains of Src. (1993) (255)
- Autoinhibition of c-Abl (2002) (255)
- The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions. (1997) (251)
- Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib (2008) (246)
- NSs Protein of Rift Valley Fever Virus Induces the Specific Degradation of the Double-Stranded RNA-Dependent Protein Kinase (2009) (244)
- Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection (2013) (241)
- Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway. (2000) (238)
- Mass spectrometry–based functional proteomics: from molecular machines to protein networks (2007) (234)
- Viral immune modulators perturb the human molecular network by common and unique strategies (2012) (231)
- c-Src-Mediated Phosphorylation of hnRNP K Drives Translational Activation of Specifically Silenced mRNAs (2002) (231)
- Systems medicine and integrated care to combat chronic noncommunicable diseases (2011) (230)
- An intramolecular SH3-domain interaction regulates c-Abl activity (1998) (224)
- The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway (1996) (213)
- Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. (2006) (203)
- Structure‐function relationships in Src family and related protein tyrosine kinases (1995) (202)
- Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation (2008) (199)
- CD14 is a coreceptor of Toll-like receptors 7 and 9 (2010) (197)
- Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia (2015) (194)
- BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. (2012) (194)
- Src kinase phosphorylates Caspase‐8 on Tyr380: a novel mechanism of apoptosis suppression (2006) (189)
- Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins (2013) (189)
- Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS (2013) (187)
- Rediscovering the sweet spot in drug discovery. (2003) (185)
- Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2 (2020) (185)
- A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses (2015) (167)
- Human Proteinpedia enables sharing of human protein data (2008) (164)
- Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra‐ and intermolecular interactions. (1995) (161)
- Charting the molecular network of the drug target Bcr-Abl (2009) (161)
- A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain (2010) (155)
- Transgenic Mouse Proteomics Identifies New 14-3-3-associated Proteins Involved in Cytoskeletal Rearrangements and Cell Signaling*S (2006) (145)
- A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis (2015) (142)
- The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src (1997) (139)
- The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity. (2014) (138)
- SAMHD1 is a nucleic‐acid binding protein that is mislocalized due to aicardi–goutières syndrome‐associated mutations (2012) (132)
- Protein complexes and proteome organization from yeast to man. (2003) (131)
- General statistical modeling of data from protein relative expression isobaric tags. (2011) (130)
- Interactome of two diverse RNA granules links mRNA localization to translational repression in neurons. (2013) (129)
- c‐Abl is an effector of Src for growth factor‐induced c‐myc expression and DNA synthesis (2002) (127)
- Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis (2011) (125)
- NANS-mediated synthesis of sialic acid is required for brain and skeletal development (2016) (119)
- JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia (2014) (117)
- Functional Dissection of the TBK1 Molecular Network (2011) (117)
- LZTR1 is a regulator of RAS ubiquitination and signaling (2018) (116)
- Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity (2014) (115)
- Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network (2015) (112)
- The −117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma‐globin gene. (1988) (110)
- Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src (2000) (108)
- Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions (2016) (107)
- Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML. (2012) (105)
- Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily (2009) (105)
- Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study (2017) (105)
- Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control? (1997) (104)
- A reversible gene trap collection empowers haploid genetics in human cells (2013) (102)
- A guide to plasma membrane solute carrier proteins (2020) (100)
- A complex prediction: three‐dimensional model of the yeast exosome (2002) (100)
- Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site (2017) (95)
- FAM111A mutations result in hypoparathyroidism and impaired skeletal development. (2013) (94)
- KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth (2015) (89)
- Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling (2015) (89)
- Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase (2001) (87)
- The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2) (2009) (87)
- A nuclear tyrosine phosphorylation circuit: c‐Jun as an activator and substrate of c‐Abl and JNK (2000) (86)
- Viperin is an iron‐sulfur protein that inhibits genome synthesis of tick‐borne encephalitis virus via radical SAM domain activity (2014) (84)
- Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression. (2012) (83)
- LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning (2017) (82)
- Proteomic analysis of human cataract aqueous humour: Comparison of one-dimensional gel LCMS with two-dimensional LCMS of unlabelled and iTRAQ®-labelled specimens. (2011) (81)
- Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. (1991) (80)
- Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl. (2005) (79)
- IFITs: Emerging Roles as Key Anti-Viral Proteins (2014) (79)
- TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9 (2020) (78)
- BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib. (2010) (77)
- KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. (2011) (75)
- The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. (2008) (75)
- Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. (2010) (73)
- Crystal structure of mammalian acid sphingomyelinase (2016) (72)
- The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL. (2012) (71)
- A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells (2010) (70)
- Regulation of the Src protein tyrosine kinase (1995) (69)
- Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration (2015) (69)
- Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis (1999) (68)
- Proteome-wide small molecule and metabolite interaction mapping (2015) (67)
- Caspase-Dependent Cleavage of c-Abl Contributes to Apoptosis (2003) (67)
- Initial characterization of the human central proteome (2011) (67)
- Recent advances in combinatorial drug screening and synergy scoring (2018) (66)
- The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity (2015) (66)
- Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-Box Protein FBXO3 To Degrade Subunit p62 of General Transcription Factor TFIIH (2014) (65)
- Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome (2015) (60)
- Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia (2015) (59)
- After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. (2011) (57)
- The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein. (1989) (56)
- Mig6 Is a Sensor of EGF Receptor Inactivation that Directly Activates c-Abl to Induce Apoptosis during Epithelial Homeostasis (2012) (56)
- Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine (2016) (55)
- A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs (2019) (53)
- Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2. (2016) (53)
- The protein CDP, but not CP1, footprints on the CCAAT region of the gamma-globin gene in unfractionated B-cell extracts. (1989) (52)
- Common Nodes of Virus–Host Interaction Revealed Through an Integrated Network Analysis (2019) (52)
- A comparative proteomic study of human skin suction blister fluid from healthy individuals using immunodepletion and iTRAQ labeling. (2012) (51)
- Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage (2015) (50)
- The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins (1997) (50)
- Charting protein complexes, signaling pathways, and networks in the immune system (2006) (49)
- Identification of Fos target genes by the use of selective induction systems (1992) (48)
- The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification (2018) (48)
- The RNA‐binding protein HuR/ELAVL1 regulates IFN‐β mRNA abundance and the type I IFN response (2015) (48)
- Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import (2020) (47)
- Nuclear tyrosine phosphorylation: the beginning of a map. (2000) (47)
- Nilotinib Exerts Direct Pro-Atherogenic and Anti-Angiogenic Effects On Vascular Endothelial Cells: A Potential Explanation For Drug-Induced Vasculopathy In CML (2013) (46)
- The Src family of protein tyrosine kinases: regulation and functions. (1993) (45)
- Global survey of the immunomodulatory potential of common drugs (2017) (45)
- Cytoplasmic Listeria monocytogenes stimulates IFN‐β synthesis without requiring the adapter protein MAVS (2006) (45)
- Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases (2008) (44)
- Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis (2020) (44)
- Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin. (1989) (44)
- Report on EU–USA Workshop: How Systems Biology Can Advance Cancer Research (27 October 2008) (2009) (43)
- Germline RBBP6 mutations in familial myeloproliferative neoplasms. (2016) (43)
- Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms (2013) (43)
- MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity (2018) (43)
- Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth (2016) (43)
- Functional crosstalk between membrane lipids and TLR biology. (2016) (42)
- mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation (2018) (42)
- The RESOLUTE consortium: unlocking SLC transporters for drug discovery (2020) (41)
- The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate (2016) (40)
- An Integrated Chemical Biology Approach Identifies Specific Vulnerability of Ewing's Sarcoma to Combined Inhibition of Aurora Kinases A and B (2011) (40)
- NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation (2014) (39)
- A network solution (2008) (39)
- Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. (2016) (38)
- Structural requirements for the efficient regulation of the Src protein tyrosine kinase by Csk. (1995) (36)
- A functional screen in yeast for regulators and antagonizers of heterologous protein tyrosine kinases (1996) (35)
- Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia (2008) (34)
- IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes (2019) (32)
- Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders (2021) (32)
- The chemokine interleukin‐8 and the surface activation protein CD69 are markers for Bcr–Abl activity in chronic myeloid leukemia (2008) (32)
- The purification and characterization of the catalytic domain of Src expressed in Schizosaccharomyces pombe. Comparison of unphosphorylated and tyrosine phosphorylated species. (1996) (32)
- Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL (2019) (32)
- Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. (2019) (31)
- A Modular Synthesis of Modified Phosphoanhydrides. (2015) (31)
- Next generation of network medicine: interdisciplinary signaling approaches. (2017) (30)
- Polymerase δ deficiency causes syndromic immunodeficiency with replicative stress. (2019) (30)
- A crystal milestone: the structure of regulated Src. (1997) (30)
- A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF (2014) (30)
- A method to resolve the composition of heterogeneous affinity-purified protein complexes assembled around a common protein by chemical cross-linking, gel electrophoresis and mass spectrometry (2012) (30)
- Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter (2017) (29)
- Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay (2018) (28)
- Phosphorylation of Bruton's tyrosine kinase by c-Abl. (2002) (28)
- A time-resolved molecular map of the macrophage response to VSV infection (2016) (28)
- A Surface Biotinylation Strategy for Reproducible Plasma Membrane Protein Purification and Tracking of Genetic and Drug-Induced Alterations. (2016) (28)
- Src regulated by C-terminal phosphorylation is monomeric. (1997) (28)
- The TLR‐independent DNA recognition pathway in murine macrophages: Ligand features and molecular signature (2009) (27)
- Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae. (2003) (27)
- A Computational Approach to Analyze the Mechanism of Action of the Kinase Inhibitor Bafetinib (2010) (26)
- Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation (2021) (25)
- Systems biology analysis of protein‐drug interactions (2012) (25)
- SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1 (2015) (25)
- Analysis of human c-Abl tyrosine kinase activity and regulation in S. pombe. (1996) (24)
- Protein interaction networks in innate immunity. (2013) (24)
- Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis (2015) (23)
- Selective serotonin reuptake inhibitors—A new modality for the treatment of lymphoma/leukaemia? (2007) (23)
- MASPECTRAS 2: An integration and analysis platform for proteomic data (2010) (22)
- Targeting a cell state common to triple-negative breast cancers (2015) (22)
- Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity. (2015) (22)
- Affinity Purification Strategies for Proteomic Analysis of Transcription Factor Complexes (2013) (22)
- Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha. (2008) (22)
- An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client* (2015) (22)
- Insights into the transport side of the human SLC38A9 transceptor. (2019) (21)
- Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking (2018) (21)
- The SH2 Domain Regulates c-Abl Kinase Activation by a Cyclin-Like Mechanism and Remodulation of the Hinge Motion (2014) (21)
- Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells (2016) (20)
- Identification of Kinase Inhibitor Targets in the Lung Cancer Microenvironment by Chemical and Phosphoproteomics (2014) (20)
- Functional organization of the yeast proteome by systemic analysis of protein complexes (2002) (20)
- The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production (2014) (20)
- Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal☆ (2017) (20)
- An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters (2021) (19)
- Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages (2021) (19)
- Combinatorial Drug Screening Identifies Ewing Sarcoma–specific Sensitivities (2016) (18)
- NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3 (2018) (18)
- Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in A431 epidermoid carcinoma cells by both chemical- and phosphoproteomics. (2014) (18)
- Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity* (2016) (18)
- Identifying Kinase Substrates via a Heavy ATP Kinase Assay and Quantitative Mass Spectrometry (2016) (18)
- Building and exploring an integrated human kinase network: Global organization and medical entry points☆ (2014) (18)
- A miniaturized chemical proteomic approach for target profiling of clinical kinase inhibitors in tumor biopsies. (2013) (16)
- Regulation of the c-Abl and BcrAbl Tyrosine Kinases (2004) (16)
- FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes (2019) (16)
- A substrate‐based ontology for human solute carriers (2020) (16)
- In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens (2018) (16)
- A Target-Disease Network Model of Second-Generation BCR-ABL Inhibitor Action in Ph+ ALL (2013) (15)
- eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition (2020) (15)
- Selective serotonin reuptake inhibitors: a new modality for the treatment of lymphoma/leukaemia? (2007) (14)
- Characterization of BCR-ABL Deletion Mutants from Patients with Chronic Myeloid Leukemia. (2007) (14)
- MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type (2014) (14)
- The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate (2016) (14)
- Target 2035 – update on the quest for a probe for every protein (2021) (13)
- Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators (2021) (13)
- IRF 1 is critical for the TNF-driven interferon response in rheumatoid fi broblast-like synoviocytes JAKinibs suppress the interferon response in RA-FLSs (2019) (13)
- Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines (2018) (13)
- Opposite effects of the p 52 shc / p 46 shc and p 66 shc splicing isoforms on the EGF receptor – MAP kinase – fos signalling pathway receptor (2013) (13)
- Germline RBBP6 Mutations In Myeloproliferative Neoplasms (2013) (12)
- Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers (2018) (12)
- NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors (2015) (12)
- TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML (2017) (11)
- Mutational dynamics and transmission properties of SARS-CoV-2 superspreading events in Austria (2020) (11)
- High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system. (2002) (11)
- Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing (2017) (10)
- The TLR-independent DNA recognition pathway in murine macrophages: Ligand features and molecular signature (2009) (10)
- The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection (2019) (10)
- Regulation of Human c-Abl Tyrosine Kinase Activity in Xenopus Oocytes and Acceleration of Progesterone-Induced G2/M Transition by Oncogenic Forms (1999) (10)
- Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A* (2016) (10)
- Profiling of Small Molecules by Chemical Proteomics. (2016) (10)
- Deconvolution of targeted protein-protein interaction maps. (2012) (9)
- Compound immobilization and drug-affinity chromatography. (2012) (9)
- Delineation of a KIT-Independent Oncogenic Pathway in Neoplastic Mast Cells That Involves Lyn and Btk, and Can Be Disrupted by the KIT/Lyn/Btk-Targeting Drug Dasatinib (2007) (9)
- Toward effective sharing of high-dimensional immunology data (2014) (9)
- Vienna special issue: Molecular machines (2007) (9)
- The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis (2019) (9)
- Patient-derived model systems and the development of next-generation anticancer therapeutics. (2020) (8)
- Finally: The digital, democratic age of scientific abstracts (2008) (8)
- Targeting allosteric regulatory modules in oncoproteins: “Drugging the Undruggable” (2011) (8)
- Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells (2019) (8)
- Recent developments in ligands and chemical probes targeting solute carrier transporters. (2021) (7)
- Further Evaluation of Pro-Atherogenic and Anti-Angiogenic Effects of Nilotinib in Mice and in Patients with Ph-Chromosome plus CML (2014) (7)
- Structural basis for the auto-inhibition of c-Abl tyrosine kinase (2003) (7)
- The Src family of protein tyrosine kinases: regulation and functions. (1993) (7)
- Where is the Future of Drug Discovery for Cancer? (2017) (7)
- Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer (2017) (7)
- Novel Global Network Scores to Analyze Kinase Inhibitor Profiles (2010) (6)
- The promise and peril of chemical probes (vol 11, pg 536, 2015) (2015) (6)
- Frequent Mutations in the Calreticulin Gene CALR in Myeloproliferative Neoplasms (2013) (5)
- Corrigendum: The promise and peril of chemical probes. (2015) (5)
- Chapter 3 – Interactome Networks (2013) (5)
- Experimental characterization of the human non-sequence-specific nucleic acid interactome (2013) (5)
- NMR Assignment Reveals an α-Helical Fold for the F-Actin Binding Domain of Human Bcr-Abl/c-Abl (2005) (5)
- Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions (2021) (5)
- Erratum: The promise and peril of chemical probes (Nature Chemical Biology (2015) 11 (536-541)) (2015) (4)
- COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight (2020) (4)
- Correction: Corrigendum: NANS-mediated synthesis of sialic acid is required for brain and skeletal development (2017) (4)
- Metabolic drug survey highlights cancer cell dependencies and vulnerabilities (2020) (4)
- Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes. (2012) (4)
- Why most transporter mutations that cause antibiotic resistance are to efflux pumps rather than to import transporters (2020) (4)
- A systematic genetic interaction map of human solute carriers assigns a role to SLC25A51/MCART1 in mitochondrial NAD uptake (2020) (4)
- Critical Nodes of Virus–Host Interaction Revealed Through an Integrated Network Analysis (2019) (4)
- Deep Morphology Learning Enhances Ex Vivo Drug Profiling-Based Precision Medicine (2022) (4)
- Mechanisms of Activation of Abl Family Kinases (2006) (4)
- Corrigendum: Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia (2017) (3)
- Analysis of TNFR2-mediated functions on osteoclast precursor cells (2010) (3)
- In silico prioritization of transporter-drug relationships from drug sensitivity screens (2018) (3)
- Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions (2022) (3)
- Systems Biology: Understanding the Biological Mosaic (2005) (3)
- Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states (2021) (3)
- Systematic Profiling and Novel Targets of the Bcr-Abl Kinase Inhibitors Imatinib, Nilotinib and Dasatinib. (2007) (2)
- Faculty Opinions recommendation of Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. (2007) (2)
- PTEN in antigen presenting cells is a master regulator for Th17-mediated autoimmune pathology (2012) (2)
- Drugs in action. (2008) (2)
- Enhancing cognate target elution efficiency in gel-free chemical proteomics (2015) (2)
- Effects of Bosutinib (SKI-606) in CML: Kinase Target Profile, Effects on BCR/ABL Mutants, and Synergism with Dasatinib in T315I+ Cells (2008) (2)
- The testis-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa. (1989) (2)
- Selenocysteine metabolism is a targetable vulnerability in MYCN-amplified cancers (2022) (2)
- Cell biology: A key driver of therapeutic innovation (2012) (2)
- Enhancing cognate target elution efficiency in gel-free chemical proteomics (2015) (2)
- A structure and evolutionary-based classification of solute carriers (2022) (1)
- AB0075 MTOR: An Unexpected Role on the TNF-Regulated MRNA Transcriptome in Rheumatoid Fibroblast-Like Synoviocytes (2015) (1)
- Viral RNA binding by the human IFIT1-IFIT3 protein complex in the innate immune response. (2015) (1)
- Treatment Guided By Next Generation Functional Drug Screening Provides Clinical Benefit in Advanced Aggressive Hematological Malignancies: Final Evaluation of the Open Label, Single Arm Exalt Trial (2020) (1)
- The Bcr-Abl SH2-Kinase Domain Interface Is Critical for Leukemogenesis and An Additional Therapeutic Target in CML. (2009) (1)
- Dasatinib (BMS354825) Inhibits IgE-Dependent Activation and Histamine Release in Human Blood Basophils. (2006) (1)
- Proteomic analysis of low quantities of cellular material in the range obtainable from scarce patient samples (2015) (1)
- Experimental characterization of the human non-sequence-specific nucleic acid interactome (2013) (1)
- Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP (2023) (1)
- A1.8 A dual role of MTOR in the rheumatoid mesenchymal tissue response to inflammation (2014) (1)
- Mutational analysis oftheSrcSH3 domain:the same residues oftheligand binding surface are important forintra- andintermolecular interactions (1995) (1)
- Bcr-Abl Directly Activates Stat5 Independent of Jak2 (2010) (1)
- Accelerating SLC Transporter Research: Streamlining Knowledge and Validated Tools (2022) (1)
- Regulation of the SRC and ABU protein tyrosine kinases (1998) (1)
- SY-20 The TBK-1 substrate DDX3X, a DEAD-box RNA helicase, provides innate immunity to listeria monocytogenes (2008) (1)
- Quinone Reductase 2 (2009) (1)
- A biomedical adventurers' guide to navigating between careers in academia and industry (2009) (1)
- Caught in the genetic network: a novel regulator of lipid metabolism (2020) (1)
- Abstract 2689: High-content imaging and single-cell analysis of drug response ex vivo is predictive of clinical outcome for hematologic cancer patients (2019) (0)
- Recruitment of the MLL complex via specific interaction of the p30 variant of C/EBPα with Wdr5 is essential for development of acute myeloid leukemia (2013) (0)
- Developmental and tissue-specific regulatiOnuOrfc iove l o f the sea transcription factor (2007) (0)
- P054 IRF-1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes (2019) (0)
- PCYT2 controls muscle health and muscle aging (2021) (0)
- 17 – Systems biology (2015) (0)
- Faculty Opinions recommendation of Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. (2007) (0)
- Pro-Atherogenic and Anti-Angiogenic Effects of Nilotinib on Endothelial Cells: A Potential Mechanism to Explain Vasculopathies in Cml Patients Treated With Nilotinib (2014) (0)
- A2.6 MTOR plays a decisive role in the mesenchymal tissue response to inflammation in arthritis (2015) (0)
- Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking (2018) (0)
- Quantitative Protein Analysis of Intraocular Fluids from Patients with Idiopathic Epiretinal Membranes (2011) (0)
- Systems Biology Analysis of Kinase Inhibitor Protein Target Profiles in Leukemia Treatments (2012) (0)
- Chapter 7:Target/s Identification Approaches – Experimental Biological Approaches (2012) (0)
- Crystal structure of NUDT1 (MTH1) with R-crizotinib (2014) (0)
- SLC20A1 at the Interface between Macrophages and Red Blood Cells (2019) (0)
- Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. (2015) (0)
- NMR Assignments of the F-actin binding domain of human Bcr-Abl/c-Abl (2005) (0)
- A6.14 mTOR Directed Mesenchymal Tissue Response to Inflammation in Arthritis (2013) (0)
- Crystal Structure of Full-Length Human IFIT5 (2013) (0)
- Investigating primary and secondary regulatory mechanisms for hypertension using genome-wide gene expression in multiple tissues and radiotelemetric blood pressure in the rat (2011) (0)
- A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery (2022) (0)
- A6.06 P120-Catenin is essential for fibroblast-like synoviocyte function in organising the synovial tissue (2016) (0)
- Ultra-deep genome mutagenesis in haploid human cells (2016) (0)
- Faculty Opinions recommendation of NALP1 in vitiligo-associated multiple autoimmune disease. (2007) (0)
- Growth controllers knocked out. (1996) (0)
- Nilotinib exerts proatherogenic and growth-inhibitory effects on endothelial cells: a potential mechanism underlying drug-related vasculopathy in Ph plus CML (2014) (0)
- Abstract 2693: Overcoming MITF-conferred resistance through dual AURKA/MAPK-axis targeting (2015) (0)
- Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl (2005) (0)
- Functional Genomic and Proteomic Characterization of Normal and Oncogenic CEBPA Variants In Myeloid Cells (2010) (0)
- Erratum to “Phosphorylation of Bruton’s tyrosine kinase by c-Abl” [Biochem. Biophys. Res. Commun. 299 (2002) 510–515] (2003) (0)
- Murine acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) (2016) (0)
- Class effects of tyrosine kinase inhibitors on osteoclastogenesis in vitro (2011) (0)
- A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in cell biology. (1997) (0)
- Structural Positioning of the SH2 Domain Is Critical for Bcr-Abl Kinase Activity, Signal Transduction and Oncogenic Transformation (2008) (0)
- Germline RBBP6 mutations in familial myeloproliferative neoplasm (2016) (0)
- P120 The cytokine mRNA-interactome – An unbiased approach to identify RNA–protein interactions (2012) (0)
- COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight [version 1; peer review: 3 approved with reservations] (2021) (0)
- Systems‐wide analysis of protein complexes in Saccharomyces cerevisiae (2007) (0)
- TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9 (2020) (0)
- Evaluation of the effects of the PKC412-metabolites CGP52421 and CGP62221 on proliferation and viability of neoplastic mast cells and IgE dependent secretion of histamine (2013) (0)
- Heme drives hemolysis-induced susceptibility to infection and sepsis via disruption of 1 phagocyte cytoskeletal dynamics 2 3 (2016) (0)
- Quantitative Proteomic Analysis of Human Aqueous Humor by an Amine-Specific Peptide-Based Labeling Technology (2010) (0)
- Impedance-Based Phenotypic Readout of Transporter Function: A Case for Glutamate Transporters (2022) (0)
- Abstract IA2: Network models in oncogene-addicted lung cancer (2012) (0)
- Murine acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) with phosphocholine (2016) (0)
- Identification of host cell factors involved in hepatitis C virus replication (2019) (0)
- Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligocytidine (2013) (0)
- Abstract 5038: Probing network fragilities in neuroblastoma by synergistic drug combinations. (2013) (0)
- Kinases A and B Vulnerability of Ewing ' s Sarcoma to Combined Inhibition of Aurora An Integrated Chemical Biology Approach Identifies Specific (2011) (0)
- Crystal Structure of N-terminal Human IFIT1 (2013) (0)
- Murine SMPDL3A in complex with ADP analog AMPCP (2016) (0)
- FRI0033 Mtor directed mesenchymal tissue response to inflammation in arthritis (2013) (0)
- Identification and secondary structure characterization of the 5 ' non-coding regions of p 53 mRNA transcripts in mouse (2016) (0)
- Preliminary diffraction studies of the regulated form of chicken SRC protein tyrosine kinase (1996) (0)
- Open form of murine Acid Sphingomyelinase (2016) (0)
- Abstract 319: Integrated ATAC-seq and single-cell synergistic chemosensitivity profiling identifies rational drug combinations in ibrutinib treated CLL patients (2019) (0)
- Investigating the interaction of Hepatitis C virus non-structural protein NS5A with the methyltransferase SMYD3 (2014) (0)
- Proceedings of the Annual Meeting of the Austrian Society of Haematology and Medical Oncology (2015) (0)
- P051 Mapping the TNF-induced necroptosis pathway by experimental test-tube genetics in human haploid cells (2012) (0)
- Abstract 5128: Physical EGFR network mapping and dynamic regulation in lung cancer cells (2011) (0)
- PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing (2023) (0)
- Protein Profiling of Human Aqueous Humor by Mass Spectrometry (2010) (0)
- Making the paper: Giulio Superti-Furga (2006) (0)
- A Web Resource for Improved Analysis of AP-MS Protein Interaction Data. (2013) (0)
- Critical role of PCYT2 in muscle health and aging (2023) (0)
- Nilotinib-induced vasculopathy : identification of vascular 1 endothelial cells as a primary target site 2 3 4 (2017) (0)
- Mass Spectrometry and its Applications to Functional Proteomics (2010) (0)
- Sulphur Inhibits the Stimulation of Fibroblast-Like Synoviocytes from Osteoarthritis Patients in a 3-D Model 03 (2019) (0)
- Functional Dissection of Dynamic Molecular Networks in Innate Immunity (2012) (0)
- Murine SMPDL3A in complex with sulfate (2016) (0)
- Minireview Regulation of the Src protein tyrosine kinase (1995) (0)
- Open form of murine Acid Sphingomyelinase in presence of lipid (2016) (0)
- Murine SMPDL3A in complex with sulfate (tetragonal) (2016) (0)
- - 1-NANS-mediated synthesis of sialic acid is required for brain and skeletal 1 development (2020) (0)
- MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity (2018) (0)
- How to end a viral RNA - lessons from the IFIT proteins (2018) (0)
- editor: Germline RBBP6 mutations in familial myeloproliferative neoplasms (2016) (0)
- OP0284 Mtor Plays A Decisive Role in the Rheumatoid Mesenchymal Tissue Response to Inflammation (2014) (0)
- Murine SMPDL3A in complex with phosphocholine (2016) (0)
- Caught in the genetic network: a novel regulator of lipid metabolism (2020) (0)
- Unbiased Profiling of the Immunomodulatory Properties of Soluble Proteins (2017) (0)
- Elucidating the molecular mechanism of action of cancer drugs in the second decade of the new millennium (2013) (0)
- A functional screen for regulators of the c-Abl protein tyrosine kinase. (1997) (0)
- Murine SMPDL3A in complex with AMP (2016) (0)
- COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight [version 1; peer review: awaiting peer review] (2020) (0)
- Murine SMPDL3A in presence of excess zinc (2016) (0)
- Catalytic domain of murine Acid Sphingomyelinase (ASMase, ASM, SMPD1) (2016) (0)
- Comparative functional analysis of the molecular network of 7 selected MLL fusion proteins (2014) (0)
- Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter (2017) (0)
- 13 Functional Proteomics of Innate Immunity Signalling (2007) (0)
- Front Cover: Proteogenomic Analysis to Identify Missing Proteins from Haploid Cell Lines (2018) (0)
- Targeting solute carriers to modulate receptor-ligand interactions. (2022) (0)
- Orthogonal screens for innate immune sensors (2009) (0)
- Quantified: Ireland (2006) (0)
- ID: 107: Inhibition of type I IFN induction by Sandfly fever Sicilian virus virulence factor NSs (2015) (0)
- Abstract A08: Genetic drug resistance screen identifies LZTR1 as regulator of RAS ubiquitination and signaling (2020) (0)
- Faculty Opinions recommendation of A loss-of-function RNA interference screen for molecular targets in cancer. (2006) (0)
- Integrated ATAC-Seq and Chemosensitivity Profiling Identifies Rational Drug Combinations in Ibrutinib-Treated CLL Patients (2017) (0)
- Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing (2023) (0)
- Deficiency Of JAGN1 Causes Severe Congenital Neutropenia Associated With Defective Secretory Pathway and Aberrant Myeloid Cell Homeostasis (2013) (0)
- patients on imatinib BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia (2011) (0)
- 04.05 The metabolic checkpoint kinase mtor regulates the rheumatoid mesenchymal tissue response to inflammation (2017) (0)
- The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection (2019) (0)
- Closed form of murine Acid Sphingomyelinase in complex with bisphosphonate inhibitor AbPA (2016) (0)
- A Subset of Chronic Myeloid Leukemia (CML) Patients on ABL Kinase Inhibitor Therapy Develop Point Mutations outside the BCR-ABL Kinase Domain That Decrease Drug Sensitivity and May Have a Role in Disease Progression. (2006) (0)
- The RESOLUTE consortium: unlocking SLC transporters for drug discovery (2020) (0)
- 311 Molecular networks in innate immunity (2008) (0)
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Giulio Superti-Furga is affiliated with the following schools:
