Graeme Henderson
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British neuroscientist whose research focuses on opioid addiction
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Graeme Henderson biology Degrees
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Biology
Graeme Henderson 's Degrees
- Masters Neurobiology University of Oxford
Why Is Graeme Henderson Influential?
(Suggest an Edit or Addition)According to Wikipedia, Graeme Henderson is a British neuroscientist whose research focuses on opioid addiction. He is professor of pharmacology in the School of Physiology, Pharmacology and Neuroscience, University of Bristol .
Graeme Henderson 's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance (2013) (645)
- Agonist‐selective mechanisms of GPCR desensitization (2008) (396)
- 75 years of opioid research: the exciting but vain quest for the Holy Grail (2006) (342)
- The orphan opioid receptor and its endogenous ligand--nociceptin/orphanin FQ. (1997) (326)
- Characterization of α2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones (1985) (251)
- μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization (2010) (247)
- Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro. (1980) (229)
- The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH‐SY5Y human neuroblastoma cell line (1996) (211)
- Noradrenaline‐mediated synaptic inhibition in rat locus coeruleus neurones. (1983) (208)
- In vitro pharmacology of the opioid peptides, enkephalins and endorphins. (1977) (197)
- A new example of a morphine‐sensitive neuro‐effector junction: Adrenergic transmission in the mouse vas deferens (1997) (183)
- Agonist-Selective Mechanisms of μ-Opioid Receptor Desensitization in Human Embryonic Kidney 293 Cells (2006) (179)
- ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain. (1998) (154)
- In vitro release of Leu- and Met-enkephalin from the corpus striatum (1978) (150)
- Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling (2020) (142)
- The novel μ‐opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception (2018) (139)
- Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N‐methyl‐D‐aspartate receptor. (1990) (135)
- μ-Opioid-receptor-mediated inhibidon of the N-type calcium-channel current (1991) (122)
- Glycine-insensitive desensitization of NMDA responses in cultured mouse embryonic neurons (1990) (111)
- Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro (1996) (110)
- Involvement of PKCα and G‐protein‐coupled receptor kinase 2 in agonist‐selective desensitization of µ‐opioid receptors in mature brain neurons (2009) (107)
- Electrophysiological evidence for presynaptic inhibition of acetylcholine release by 5-hydroxytryptamine in the enteric nervous system (1980) (104)
- Protein Kinase C Activation Enhances Morphine-Induced Rapid Desensitization of μ-Opioid Receptors in Mature Rat Locus Ceruleus Neurons (2004) (103)
- How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance? (2006) (102)
- Central sensitization as a result of surgical pain: investigation of the pre-emptive value of pethidine for ovariohysterectomy in the rat (1995) (97)
- Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons (2009) (95)
- μ-Opioid Receptor Desensitization in Mature Rat Neurons: Lack of Interaction between DAMGO and Morphine (2003) (93)
- Endomorphin-2: A Biased Agonist at the μ-Opioid Receptor (2012) (91)
- Somatostatin Receptor Desensitization in NG108-15 Cells (1998) (83)
- Modulation of fast synaptic transmission by presynaptic ligand-gated cation channels. (2000) (81)
- Kappa opioid receptor activation depresses excitatory synaptic input to rat locus coeruleus neurons in vitro (1987) (80)
- The Effect of Protein Kinase C and G Protein-Coupled Receptor Kinase Inhibition on Tolerance Induced by μ-Opioid Agonists of Different Efficacy (2010) (76)
- THE EFFECTS OF MORPHINE ON THE RELEASE OF NORADRENALINE FROM THE CAT ISOLATED NICTITATING MEMBRANE AND THE GUINEA‐PIG ILEUM MYENTERIC PLEXUS‐LONGITUDINAL MUSCLE PREPARATION (1975) (76)
- Does alcohol increase the risk of overdose death: the need for a translational approach. (2008) (75)
- THE EFFECTS OF MORPHINE ON THE RELEASE OF NORADRENALINE FROM THE MOUSE VAS DEFERENS (1976) (75)
- Substance P excitation of rat locus coeruleus neurones. (1983) (74)
- δ‐ and μ‐opioid receptor mobilization of intracellular calcium in SH‐SY5Y human neuroblastoma cells (1996) (72)
- Glycine and GABAA receptor‐mediated synaptic transmission in rat substantia gelatinosa: inhibition by μ‐opioid and GABAB agonists (1998) (70)
- ATP‐gated cation channels (P2X purinoceptors) in trigeminal mesencephalic nucleus neurons of the rat. (1997) (69)
- Fentanyl depression of respiration: comparison with heroin and morphine (2019) (69)
- Role of G Protein–Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization (2015) (66)
- Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine (2015) (64)
- Critical Assessment of G Protein-Biased Agonism at the μ-Opioid Receptor. (2020) (62)
- Hyperpolarization‐activated cationic currents (Ih) in neurones of the trigeminal mesencephalic nucleus of the rat (1998) (61)
- Antinociceptive and morphine modulatory actions of spinal orphanin FQ (1998) (58)
- Putative pre- and postsynaptic ATP-sensitive potassium channels in the rat substantia nigra in vitro (1995) (57)
- Locus Coeruleus Neurons (1984) (57)
- Baclofen inhibition of the hyperpolarization-activated cation current, Ih, in rat substantia nigra zona compacta neurons may be secondary to potassium current activation. (1996) (56)
- Neural function: metabolism and actions of inositol metabolites in mammalian brain. (1988) (49)
- Coincident signalling between the Gi/Go‐coupled δ‐opioid receptor and the Gq‐coupled m3 muscarinic receptor at the level of intracellular free calcium in SH‐SY5Y cells (2001) (48)
- Identification of phosphorylation sites in the COOH‐terminal tail of the μ‐opioid receptor (2013) (45)
- Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice (2008) (45)
- Endocytosis of G Protein-Coupled Receptors Is Regulated by Clathrin Light Chain Phosphorylation (2012) (44)
- Mu-opioid receptor inhibition of calcium current: development of homologous tolerance in single SH-SY5Y cells after chronic exposure to morphine in vitro. (1991) (43)
- Opioid elevation of intracellular free calcium: possible mechanisms and physiological relevance. (2006) (42)
- Comparison of ethyl glucuronide in hair with self-reported alcohol consumption. (2012) (41)
- Characterisation of the L- and N-type calcium channels in differentiated SH-SY5Y neuroblastoma cells: calcium imaging and single channel recording. (1992) (40)
- Oxycodone‐induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition (2018) (39)
- Action of morphine on guinea-pig myenteric plexus and mouse vas deferens studied by intracellular recording. (1975) (38)
- Electrophysiological analysis of opioid action in the central nervous system. (1983) (38)
- Di-isopropyl phosphofluoridate-induced antinociception: possible role of endogenous opioids. (1980) (37)
- Neuropeptide Y Y2 receptor and somatostatin sst2 receptor coupling to mobilization of intracellular calcium in SH‐SY5Y human neuroblastoma cells (1997) (36)
- DEPRESSION BY MORPHINE OF EXCITATORY JUNCTION POTENTIALS IN THE VAS DEFERENS OF THE MOUSE (1976) (36)
- Ca2+ entry following store depletion in SH-SY5Y neuroblastoma cells. (1996) (35)
- A Novel G Protein–Biased Agonist at the δ Opioid Receptor with Analgesic Efficacy in Models of Chronic Pain (2019) (35)
- Actions of phencyclidine on rat locus coeruleus neurones in vitro (1986) (34)
- Localization of high affinity [3H]glibenclamide binding sites within the substantia nigra zona reticulata of the rat brain (1994) (32)
- Inhibition of potassium currents by the sigma receptor ligand (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine in sympathetic neurons of the mouse isolated hypogastric ganglion (1990) (31)
- Electrophysiological properties of neurones contained in the locus coeruleus and mesencephalic nucleus of the trigeminal nerve in vitro (2004) (30)
- How the complex pharmacology of the fentanyls contributes to their lethality (2019) (30)
- Reversal of Morphine Analgesic Tolerance by Ethanol in the Mouse (2013) (30)
- Characterization of the neurons of the mouse hypogastric ganglion: morphology and electrophysiology. (1990) (29)
- MODIFICATION OF CATECHOLAMINE RELEASE BY NARCOTIC ANALGESICS AND OPIOID PEPTIDES (1979) (28)
- Properties of native P2X receptors in rat trigeminal mesencephalic nucleus neurones: lack of correlation with known, heterologously expressed P2X receptors (2001) (27)
- δ-opioid Receptor Mobilization of Intracellular Calcium in SH-SY5Y Cells: Lack of Evidence for δ-receptor Subtypes (1997) (27)
- Chronic exposure to morphine does not induce dependence at the level of the calcium channel current in human SH-SY5Y cells (1992) (26)
- The variation of noradrenaline output with frequency of nerve stimulation and the effect of morphine on the cat nictitating membrane and on the guinea-pig myenteric plexus. (1972) (26)
- μ-Opioid receptor desensitization: homologous or heterologous? (2012) (24)
- Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor (2017) (24)
- Evidence for an important role of protein phosphatases in the mechanism of morphine tolerance (2007) (24)
- Lack of evidence for coupling of the dopamine D2 receptor to an adenosine triphosphate-sensitive potassium (ATP-K+) channel in dopaminergic neurones of the rat substantia nigra (1992) (23)
- Morphine-induced changes in the sensitivity of the isolated colon and vas deferens of the rat. (1972) (22)
- Activation of μ‐ and δ‐opioid receptors present on the same nerve terminals depresses transmitter release in the mouse hypogastric ganglion (1990) (21)
- C‐terminal splice variants of the μ‐opioid receptor: existence, distribution and functional characteristics (2008) (21)
- Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone (2017) (20)
- The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours (2014) (19)
- Drug abuse: from gene through cell to behaviour (2005) (19)
- Methadone: does it really have low efficacy at μ-opioid receptors? (2008) (19)
- Ethanol Reversal of Cellular Tolerance to Morphine in Rat Locus Coeruleus Neurons (2013) (19)
- An examination of the putative σ‐receptor in the mouse isolated vas deferens (1989) (18)
- Effect of normorphine and enkephalin on spontaneous potentials in the vas deferens. (1976) (18)
- Effects of Angiotensin II on [3H]Noradrenaline Release and Phosphatidylinositol Hydrolysis in the Parietal Cortex and Locus Coeruleus of the Rat (1987) (18)
- Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization. (2003) (18)
- Proceedings: Modulation of frequency-dependent noradrenaline release by calcium, angiotensin and morphine. (1974) (16)
- Effect of Tamoxifen and Brain-Penetrant Protein Kinase C and c-Jun N-Terminal Kinase Inhibitors on Tolerance to Opioid-Induced Respiratory Depression in Mice (2017) (15)
- Antinociceptive and morphine modulatory actions of spinal orphanin FQ. (1998) (15)
- delta- and mu-opioid receptor mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells. (1996) (14)
- Phenycyclidine A widely abused but little understood psychotomimetic agent (1982) (14)
- δ and μ opioid receptor mobilization of intracellular calcium in neuroblastoma cells (1994) (11)
- Morphine‐induced internalization of the L83I mutant of the rat μ‐opioid receptor (2015) (9)
- Kappa opiate receptor activation in the rat locus coeruleus (1984) (9)
- The sigma [corrected] ligand rimcazole antagonises (+)SKF 10,047, but not (+)3-PPP, in the mouse isolated vas deferens. (1990) (9)
- Enhancement of μ-Opioid Receptor Desensitization by Nitric Oxide in Rat Locus Coeruleus Neurons: Involvement of Reactive Oxygen Species (2012) (9)
- Characterization of two components of the N-like, high-threshold-activated calcium channel current in differentiated SH-SY5Y cells (1990) (8)
- Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (8)
- Bradykinin Inhibition of N- and L-type Calcium Channel Currents in NG108-15 Cells (1997) (8)
- The μ‐opioid receptor: an electrophysiologist's perspective from the sharp end (2015) (8)
- Activation of mu- and delta-opioid receptors present on the same nerve terminals depresses transmitter release in the mouse hypogastric ganglion. (1990) (7)
- Synthetic cannabinoids and potential cardiac arrhythmia risk: an important message for drug users (2020) (7)
- Ethanol Reversal of Oxycodone Tolerance in Dorsal Root Ganglia Neurons (2018) (7)
- Effect of tamoxifen and brain penetrant PKC and JNK inhibitors on tolerance to opioid-induced respiratory depression in mice (2017) (6)
- Proceedings: Presynaptic action of 5-hydroxytryptamine in the myenteric plexus of the guinea-pig ileum. (1975) (6)
- Reversal of oxycodone and hydrocodone tolerance by diazepam (2017) (5)
- Complexity of 5-HT pharmacology compounded by electrophysiological data. (1990) (5)
- A new example of a morphine‐sensitive neuro‐effector junction: adrenergic transmission in the mouse vas deferens (1972) (5)
- The effect of extracellular sodium ion concentration on the action of opiates to inhibit potassium-evoked release of [3H]noradrenaline from the mouse vas deferens. (1981) (4)
- Fentanyl binds to the μ-opioid receptor via the lipid membrane and transmembrane helices (2021) (4)
- A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase (2020) (4)
- THEMED ISSUE: GPCR RESEARCH PAPER Involvement of PKCa and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of m-opioid receptors in mature brain neurons (2009) (2)
- Interaction With the Lipid Membrane Influences Fentanyl Pharmacology (2022) (2)
- Characterization of substance P-mediated excitation in the rat locus coeruleus (1982) (2)
- Prolonged ethanol administration prevents the development of tolerance to morphine-induced respiratory depression. (2019) (2)
- Opioid receptors in GtoPdb v.2021.3 (2021) (2)
- Electrophysiological analysis of kappa opiate receptor activation in the rabbit vas deferens (1984) (2)
- Effect of monoamine oxidase (MAO) inhibition upon the N, P and LN potentials of the rabbit superior cervical ganglia. (1971) (2)
- THEEFFECTSOF MORPHINEON THE RELEASEOF NORADRENALINEFROM THECATISOLATEDNICTITATING MEMBRANE AND THEGUINEA-PIG ILEUMMYENTERIC PLEXUS-LONGITUDINAL MUSCLEPREPARATION (1975) (2)
- Role of G Protein – Coupled Receptor Kinases 2 and 3 in m-Opioid Receptor Desensitization and Internalization s (2015) (2)
- Is there a role for protein kinase A in rapid desensitization of δ-opioid and somatostatin responses in NG108-15 cells? (1994) (1)
- OPIOID RECEPTORS (2002) (1)
- 6- and ,u-opioid receptor mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cells (2006) (1)
- δ-OPIOJD RECEPTOR MOBILIZATION OF INTRACELLULAR CALCIUM IN SH-SY5Y CELLS: LACK OF EVIDENCE FOR 8 RECEPTOR SUBTYPES (1995) (1)
- Emerging areas of opioid pharmacology (2018) (1)
- An examination of the putative sigma-receptor in the mouse isolated vas deferens. (1989) (1)
- The British Pharmacological Society: 75 years old and thriving. (2006) (1)
- delta-opioid receptor mobilization of intracellular calcium in SH-SY5Y cells: lack of evidence for delta-receptor subtypes. (1997) (1)
- UNDERSTANDING CAUSAL PATHWAYS: A RESPONSE TO THE COMMENTARIES (2008) (1)
- THE INTERACTION BETWEEN OPIOID AND MUSCARINIC RECEPTORS IN THE MOBILIZATION OF INTRACELLULAR CALCIUM IN SH-SY5Y CELLS (1995) (1)
- P.3.013 Interaction between alcohol and opioids in opioid-dependent subjects (2010) (1)
- Role of Acetaldehyde in Ethanol Reversal of Morphine Tolerance (2018) (0)
- Functional selectivity in GPCR desensitization (2008) (0)
- At the end of the day, receptors get tired too (2007) (0)
- P.6.c.008 Respiratory changes following benzodiazepine administration in opioid-dependent human participants (2010) (0)
- Running Title : Ethanol Reversal of Oxycodone and Hydrocodone Tolerances (2017) (0)
- A new example of a morphine‐sensitive neuro‐effector junction: adrenergic transmission in the mouse vas deferens (1997) (0)
- signalling with ability to activate internalization (2010) (0)
- Characterization of the Ability of Diazepam to Reverse Prescription Opioid Tolerance (2017) (0)
- Agonist-dependent Changes in the Membrane Organisation of the-Opioid Receptor in HEK 293 Cells (2010) (0)
- Inhibition by morphine of the N-like calcium current in the human neuroblastoma cell line SH-SY5Y (1990) (0)
- The distribution and desensitisation of μ-opioid receptor (MOR) splice variants (2007) (0)
- Ethanol and pregabalin reverse oxycodone tolerance (2018) (0)
- receptor agonist depresses respiration and induces tolerance antinociception. (2018) (0)
- Microsoft Word-Jacob Revised MS110775 01242018_Hamid edit.docx (2018) (0)
- ANTINOCICEPTIVE EFFECTS OF A NEW CENTRALLY-ACTING MUSCLE RELAXANT DS 103-282 ON CAT DORSAL HORN NEURONES (2007) (0)
- An in vitro model of cellular tolerance to morphine in adult rat neurons: role of protein kinase C (2004) (0)
- GRK-mediated Phosphorylation of Mu-opioid Receptor At Serine 375 Induced By A Range Of Opioid Agonists (2010) (0)
- The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours (2014) (0)
- Depression ofglutamatergic transmission bynociceptin inthe neonatal rathemisected spinal cordpreparation invitro (1996) (0)
- Pharmacology: what is it and how is it important to the health and wealth of the UK? (2006) (0)
- P.6.c.009 Comparison of a benzodiazepine and alcohol challenge in opioid dependent human participants (2011) (0)
- Morphine tolerance is dependent upon PKC activation at the level of the mu-opioid receptor (2005) (0)
- Methods of inhibiting endocytosis in neuronal cells for the study of G-protein coupled receptor desensitization (2000) (0)
- μ-opioid receptor desensitization: agonist-specific involvement of protein kinase C and G-protein coupled receptor kinases (2005) (0)
- An examination of the putative o-receptor in the mouse isolated vas deferens (2006) (0)
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