Graeme Milligan
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Graeme Milligan's Degrees
- Bachelors Biology University of Dundee
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(Suggest an Edit or Addition)Graeme Milligan's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification of a serotonin/glutamate receptor complex implicated in psychosis (2008) (749)
- Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers (2006) (567)
- G Protein–Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives (2014) (496)
- G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology (2004) (481)
- Heterotrimeric G‐proteins: a short history (2006) (456)
- Tailoring cAMP-signalling responses through isoform multiplicity. (1997) (449)
- Building a new conceptual framework for receptor heteromers. (2009) (376)
- G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor (2005) (362)
- G protein‐coupled receptor hetero‐dimerization: contribution to pharmacology and function (2009) (332)
- The dynamic role of palmitoylation in signal transduction. (1995) (310)
- International Union of Pharmacology. LXXI. Free Fatty Acid Receptors FFA1, -2, and -3: Pharmacology and Pathophysiological Functions (2008) (308)
- International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers (2007) (299)
- Inverse agonism: pharmacological curiosity or potential therapeutic strategy? (1995) (289)
- Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain. (1987) (283)
- Monitoring Receptor Oligomerization Using Time-resolved Fluorescence Resonance Energy Transfer and Bioluminescence Resonance Energy Transfer (2001) (273)
- Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective. (2003) (267)
- Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes (2010) (264)
- Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements (2010) (258)
- The experimental power of FR900359 to study Gq-regulated biological processes (2015) (251)
- Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins. (1988) (248)
- Receptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled Receptor* (2000) (242)
- Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts. (1993) (228)
- Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences. (2002) (225)
- Methods to monitor the quaternary structure of G protein‐coupled receptors (2005) (221)
- Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function* (2006) (210)
- Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes (1987) (202)
- Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2. (1990) (201)
- A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor. (1997) (200)
- The Pharmacology and Function of Receptors for Short-Chain Fatty Acids (2016) (182)
- Principles: Extending the utility of [35S]GTPγS binding assays (2003) (182)
- G protein-coupled receptor dimerisation: molecular basis and relevance to function. (2007) (179)
- The α1b-Adrenoceptor Exists as a Higher-Order Oligomer: Effective Oligomerization Is Required for Receptor Maturation, Surface Delivery, and Function (2007) (179)
- Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production. (2020) (177)
- β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle (2016) (177)
- Complex Pharmacology of Free Fatty Acid Receptors. (2017) (172)
- Metabolism meets immunity: The role of free fatty acid receptors in the immune system. (2016) (171)
- Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells (2011) (167)
- Allosteric modulation of heterodimeric G-protein-coupled receptors. (2007) (166)
- Derivation of Endothelial Cells From Human Embryonic Stem Cells by Directed Differentiation: Analysis of MicroRNA and Angiogenesis In Vitro and In Vivo (2010) (164)
- The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism (2013) (160)
- Inverse agonism and the regulation of receptor number. (1997) (159)
- Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells. (2009) (159)
- Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells (1989) (152)
- Discovery of a potent and selective GPR120 agonist. (2012) (151)
- Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system. (1993) (151)
- The chemokine receptor CCX‐CKR mediates effective scavenging of CCL19 in vitro (2006) (149)
- G-protein-coupled receptor heterodimers: pharmacology, function and relevance to drug discovery. (2006) (139)
- β-Arrestin 1 and Gαq/11 Coordinately Activate RhoA and Stress Fiber Formation following Receptor Stimulation* (2005) (138)
- Mechanisms of multifunctional signalling by G protein-linked receptors. (1993) (138)
- The CXCR1 and CXCR2 Receptors Form Constitutive Homo- and Heterodimers Selectively and with Equal Apparent Affinities* (2005) (135)
- A novel N-terminal motif for palmitoylation of G-protein alpha subunits. (1993) (133)
- Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and Gαq/11 (1995) (132)
- Muscarinic M‐current inhibition via G alpha q/11 and alpha‐adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neurones. (1994) (132)
- β-Arrestin 2-Dependent Angiotensin II Type 1A Receptor-Mediated Pathway of Chemotaxis (2005) (131)
- Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production (2017) (130)
- Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go. (1988) (127)
- The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. (1987) (127)
- Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain. (1986) (125)
- Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling* (2016) (122)
- The role of dimerisation in the cellular trafficking of G-protein-coupled receptors. (2010) (122)
- Protein-protein interactions at G-protein-coupled receptors. (2001) (121)
- Dimers of Class A G Protein-coupled Receptors Function via Agonist-mediated Trans-activation of Associated G Proteins* (2003) (121)
- Insights into ligand pharmacology using receptor-G-protein fusion proteins. (2000) (120)
- Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors. (2004) (120)
- A day in the life of a G protein‐coupled receptor: the contribution to function of G protein‐coupled receptor dimerization (2008) (118)
- Oligomerisation of G-protein-coupled receptors. (2001) (118)
- Techniques: Promiscuous Gα proteins in basic research and drug discovery (2005) (117)
- G16 as a universal G protein adapter: implications for agonist screening strategies. (1996) (114)
- Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications. (1993) (111)
- Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils. (1986) (110)
- Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists (2011) (110)
- Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3* (2012) (110)
- Conserved Polar Residues in Transmembrane Domains V, VI, and VII of Free Fatty Acid Receptor 2 and Free Fatty Acid Receptor 3 Are Required for the Binding and Function of Short Chain Fatty Acids* (2008) (108)
- Agonist-induced endocytosis and recycling of the gonadotropin-releasing hormone receptor: effect of beta-arrestin on internalization kinetics. (1998) (107)
- beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. (2005) (106)
- Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function* (2012) (106)
- Role of MicroRNAs 99b, 181a, and 181b in the Differentiation of Human Embryonic Stem Cells to Vascular Endothelial Cells (2012) (105)
- The Prevalence, Maintenance, and Relevance of G Protein–Coupled Receptor Oligomerization (2013) (104)
- Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodelling. (2014) (104)
- Multiple Interactions between Transmembrane Helices Generate the Oligomeric α1b-Adrenoceptor (2004) (103)
- Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor* (2013) (99)
- BRET analysis of GPCR oligomerization: newer does not mean better (2007) (99)
- The dually acylated NH2-terminal domain of gi1alpha is sufficient to target a green fluorescent protein reporter to caveolin-enriched plasma membrane domains. Palmitoylation of caveolin-1 is required for the recognition of dually acylated g-protein alpha subunits in vivo. (1999) (97)
- Down-regulation of Gi sub-types by prolonged incubation of adipocytes with an A1 adenosine receptor agonist. (1990) (97)
- Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor. (1998) (96)
- Real-time monitoring of redox changes in the mammalian endoplasmic reticulum (2011) (95)
- Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays. (2007) (95)
- Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. (2010) (94)
- The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins Gi and Go (1987) (92)
- Hormonal regulation of Gi2 α-subunit phosphorylation in intact hepatocytes (1990) (92)
- The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase. (1985) (92)
- Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia (2016) (91)
- Heteromultimerization of Cannabinoid CB1 Receptor and Orexin OX1 Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A* (2011) (91)
- Angiotensin1‐9 antagonises pro‐hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor (2011) (91)
- Constitutive Activity of the Cannabinoid CB1 Receptor Regulates the Function of Co-expressed Mu Opioid Receptors* (2008) (88)
- Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice. (2007) (88)
- Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases. (2015) (86)
- Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13. (2010) (86)
- The α Subunit of Gq Contributes to Muscarinic Inhibition of the M-Type Potassium Current in Sympathetic Neurons (1998) (86)
- Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells. (2009) (86)
- Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation. (1996) (85)
- Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis (2012) (85)
- Up-regulation of the Angiotensin II Type 1 Receptor by the MAS Proto-oncogene Is Due to Constitutive Activation of Gq/G11 by MAS* (2006) (85)
- The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane. (2013) (84)
- Mechanism and Function of Drosophila capa GPCR: A Desiccation Stress-Responsive Receptor with Functional Homology to Human NeuromedinU Receptor (2012) (84)
- GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base (2010) (82)
- Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins. (1992) (81)
- Principles: extending the utility of [35S]GTP gamma S binding assays. (2003) (81)
- Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants. (1997) (81)
- The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation. (2005) (80)
- The G Protein α Subunit Has a Key Role in Determining the Specificity of Coupling to, but Not the Activation of, G Protein-gated Inwardly Rectifying K+ Channels* (2000) (80)
- Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 1. Overview and models for probes of structure, properties and function in single cells (2013) (80)
- Palmitoylation Regulates Regulators of G-protein Signaling (RGS) 16 Function (2003) (80)
- Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists (2009) (79)
- Inverse agonist-induced up-regulation of the human beta2-adrenoceptor in transfected neuroblastoma X glioma hybrid cells. (1996) (79)
- Gs alpha mediates epidermal growth factor-elicited stimulation of rat cardiac adenylate cyclase. (1990) (78)
- Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi (1989) (78)
- G‐proteins and G‐protein subunits mediating cholinergic inhibition of N‐type calcium currents in sympathetic neurons (1998) (78)
- Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain. (1987) (78)
- The Action and Mode of Binding of Thiazolidinedione Ligands at Free Fatty Acid Receptor 1*♦ (2009) (78)
- The gonadotrophin-releasing hormone receptor of alpha T3-1 pituitary cells regulates cellular levels of both of the phosphoinositidase C-linked G proteins, Gq alpha and G11 alpha, equally. (1994) (77)
- A pH-sensitive fluor, CypHer 5, used to monitor agonist-induced G protein-coupled receptor internalization in live cells. (2002) (77)
- Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-[35S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist (2007) (76)
- Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists (2014) (75)
- G protein-coupled receptors for free fatty acids. (2006) (75)
- Domain Swapping in the Human Histamine H1 Receptor (2004) (74)
- Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator (2011) (74)
- Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs (2012) (74)
- CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer (2008) (73)
- Chimaeric Gα proteins: their potential use in drug discovery (1999) (73)
- Inferring Signaling Pathway Topologies from Multiple Perturbation Measurements of Specific Biochemical Species (2010) (73)
- Visualizing differences in ligand‐induced β‐arrestin–GFP interactions and trafficking between three recently characterized G protein‐coupled receptors (2001) (72)
- Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes. (1990) (72)
- Interactions between the Mas-Related Receptors MrgD and MrgE Alter Signalling and Trafficking of MrgD (2006) (72)
- Ligand regulation of green fluorescent protein‐tagged forms of the human β1‐ and β2‐adrenoceptors; comparisons with the unmodified receptors (2000) (72)
- GPCR homo-oligomerization (2019) (71)
- Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs). (1989) (70)
- Robustness of G Proteins in Alzheimer's Disease: An Immunoblot Study (1991) (70)
- Multiple Roles for the C-terminal Tail of the Chemokine Scavenger D6* (2008) (69)
- Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster alpha1B-adrenoceptor by ligands that act as inverse agonists. (1997) (69)
- Comparative analysis of the efficacy of A1 adenosine receptor activation of Gi/o alpha G proteins following coexpression of receptor and G protein and expression of A1 adenosine receptor-Gi/o alpha fusion proteins. (1999) (69)
- βγ dimers derived from Go and Gi proteins contribute different components of adrenergic inhibition of Ca2+ channels in rat sympathetic neurones (1999) (68)
- When simple agonism is not enough: Emerging modalities of GPCR ligands (2011) (68)
- Protean Agonism at the Dopamine D2 Receptor: (S)-3-(3-Hydroxyphenyl)-N-propylpiperidine Is an Agonist for Activation of Go1 but an Antagonist/Inverse Agonist for Gi1,Gi2, and Gi3 (2007) (68)
- β-Arrestin 1 Inhibits the GTPase-Activating Protein Function of ARHGAP21, Promoting Activation of RhoA following Angiotensin II Type 1A Receptor Stimulation (2010) (68)
- Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain. (1985) (68)
- The Regulator of G Protein Signaling RGS4 Selectively Enhances α2A-Adreoreceptor Stimulation of the GTPase Activity of Go1α and Gi2α* (2000) (68)
- Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the alpha subunit of the G-protein Gq. (1993) (68)
- Gi down-regulation as a mechanism for heterologous desensitization in adipocytes. (1992) (67)
- Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity. (2016) (67)
- G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease (2015) (66)
- GPR35 as a Novel Therapeutic Target (2011) (65)
- The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice. (2011) (65)
- FFA4/GPR120: Pharmacology and Therapeutic Opportunities (2017) (64)
- Agonist activation of the G protein‐coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα13 and β‐arrestin‐2 (2011) (63)
- A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias* (2016) (63)
- Identification of Two Distinct Isoforms of the Guanine Nucleotide Binding Protein Go in Neuroblastoma × Glioma Hybrid Cells: Independent Regulation During Cyclic AMP‐Induced Differentiation (1990) (63)
- High-content assays for ligand regulation of G-protein-coupled receptors. (2003) (63)
- Techniques: promiscuous Galpha proteins in basic research and drug discovery. (2005) (63)
- Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4* (2014) (63)
- Combinatorial expression of GPCR isoforms affects signalling and drug responses (2020) (62)
- Guanine-nucleotide-binding proteins expressed in rat white adipose tissue. Identification of both mRNAs and proteins corresponding to Gi1, Gi2 and Gi3. (1989) (62)
- Using the Flp-In™ T-Rex™ system to regulate GPCR expression. (2011) (61)
- Ligand Regulation of the Quaternary Organization of Cell Surface M3 Muscarinic Acetylcholine Receptors Analyzed by Fluorescence Resonance Energy Transfer (FRET) Imaging and Homogeneous Time-resolved FRET* (2010) (61)
- Exploring the dynamics of regulation of G protein‐coupled receptors using green fluorescent protein (1999) (61)
- The role of GPCR dimerisation/oligomerisation in receptor signalling. (2006) (61)
- Characterizing pharmacological ligands to study the long‐chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4 (2015) (61)
- Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry. (1998) (61)
- Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Gi alpha and activation of a phospholipase C. (1990) (61)
- A Highly Conserved Glycine within Linker I and the Extreme C Terminus of G Protein α Subunits Interact Cooperatively in Switching G Protein-Coupled Receptor-to-Effector Specificity (2005) (60)
- Developing Chemical Genetic Approaches to Explore G Protein-Coupled Receptor Function: Validation of the Use of a Receptor Activated Solely by Synthetic Ligand (RASSL) (2011) (60)
- S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine. (2000) (60)
- Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins. (1988) (59)
- Evidence for Distinct Antagonist-Revealed Functional States of 5-Hydroxytryptamine2A Receptor Homodimers (2009) (59)
- The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No. (1986) (59)
- High-affinity interactions between human α1A-adrenoceptor C-terminal splice variants produce homo- and heterodimers but do not generate the α1L-adrenoceptor (2004) (59)
- Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3 (2009) (58)
- Orthologue selectivity and ligand bias: translating the pharmacology of GPR35. (2011) (58)
- Regulation of Oligomeric Organization of the Serotonin 5-Hydroxytryptamine 2C (5-HT2C) Receptor Observed by Spatial Intensity Distribution Analysis* (2015) (58)
- G Protein Coupling and Ligand Selectivity of the D2L and D3 Dopamine Receptors (2008) (57)
- Real Time Visualization of Agonist-mediated Redistribution and Internalization of a Green Fluorescent Protein-tagged Form of the Thyrotropin-releasing Hormone Receptor* (1998) (57)
- The Molecular Basis of Ligand Interaction at Free Fatty Acid Receptor 4 (FFA4/GPR120)* (2014) (56)
- Analysis of the role of receptor number in defining the intrinsic activity and potency of partial agonists in neuroblastoma x glioma hybrid NG108-15 cells transfected to express differing levels of the human beta 2-adrenoceptor. (1995) (55)
- Regional Distribution and Quantitative Measurement of the Phosphoinositidase C‐Linked Guanine Nucleotide Binding Proteins G1α and Gqα in Rat Brain (1993) (55)
- Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties. (2012) (55)
- Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction. (2004) (55)
- Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells. (1990) (54)
- Complex Pharmacology of Novel Allosteric Free Fatty Acid 3 Receptor Ligands (2014) (54)
- Cellular localization and pharmacological characterization of functioning alpha-1 adrenoceptors by fluorescent ligand binding and image analysis reveals identical binding properties of clustered and diffuse populations of receptors. (1998) (53)
- Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability. (2013) (53)
- Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein–Coupled Receptor 120 (2016) (53)
- Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes (2013) (53)
- Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP. (1988) (52)
- Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates. (1988) (52)
- The Antiallergic Mast Cell Stabilizers Lodoxamide and Bufrolin as the First High and Equipotent Agonists of Human and Rat GPR35 (2014) (52)
- Selective Interactions between Helix VIII of the Human μ-Opioid Receptors and the C Terminus of Periplakin Disrupt G Protein Activation* (2003) (52)
- Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States (2017) (51)
- Molecular manipulation of G-protein-coupled receptors: a new avenue into drug discovery. (2000) (51)
- Kinetics of Ternary Complex Formation with Fusion Proteins Composed of the A1-Adenosine Receptor and G Protein α-Subunits* (1999) (51)
- Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity. (1990) (50)
- Src-mediated RGS16 Tyrosine Phosphorylation Promotes RGS16 Stability* (2003) (50)
- Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides. (1996) (50)
- G‐protein‐coupled receptors: an update (2007) (50)
- Widespread distribution of Gqα/Gllα detected immunologically by an antipeptide antiserum directed against the predicted C‐terminal decapeptide (1991) (50)
- Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors. (2011) (50)
- Chemically induced hypothyroidism produces elevated amounts of the alpha subunit of the inhibitory guanine nucleotide binding protein (Gi) and the beta subunit common to all G-proteins. (1987) (50)
- Persistent activation of the alpha subunit of Gs promotes its removal from the plasma membrane. (1989) (49)
- Human D2 and D4 dopamine receptors couple through β γ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respectively (1998) (49)
- Rescue of Functional Interactions between the α2A-Adrenoreceptor and Acylation-resistant Forms of Gi1α by Expressing the Proteins from Chimeric Open Reading Frames* (1997) (49)
- Agonist control of G-protein levels. (1991) (49)
- Functional Homomers and Heteromers of Dopamine D2L and D3 Receptors Co-exist at the Cell Surface (2012) (49)
- Wortmannin-sensitive Activation of p70 by Endogenous and Heterologously Expressed G-coupled Receptors (*) (1996) (49)
- Palmitoylation Regulates Regulator of G-protein Signaling (RGS) 16 Function (2003) (49)
- Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein Gq alpha/G11 alpha following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells. (1993) (49)
- Agonist occupancy of a single monomeric element is sufficient to cause internalization of the dimeric beta2-adrenoceptor. (2007) (49)
- Concurrent down-regulation of IP prostanoid receptors and the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs) during prolonged exposure of neuroblastoma x glioma cells to prostanoid agonists. Quantification and functional implications. (1992) (49)
- Distribution of G-proteins in rat liver plasma-membrane domains and endocytic pathways. (1989) (48)
- Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base (2007) (48)
- Selective deficiency of guanine nucleotide-binding protein Go in two dopamine-resistant pituitary tumors. (1988) (48)
- Regulation of Spontaneous Activity of the δ‐Opioid Receptor: Studies of Inverse Agonism in Intact Cells (1997) (48)
- Morphine Desensitization, Internalization, and Down-Regulation of the μ Opioid Receptor Is Facilitated by Serotonin 5-Hydroxytryptamine2A Receptor Coactivation (2008) (48)
- N-terminal fatty acylation of the alpha-subunit of the G-protein Gi1: only the myristoylated protein is a substrate for palmitoylation. (1994) (48)
- Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 (1991) (48)
- Analysis of the C-terminal tail of the rat thyrotropin-releasing hormone receptor-1 in interactions and cointernalization with beta-arrestin 1-green fluorescent protein. (2001) (47)
- Novel Role for Proteinase-activated Receptor 2 (PAR2) in Membrane Trafficking of Proteinase-activated Receptor 4 (PAR4)* (2012) (47)
- Lymphocyte trafficking through the blood–brain barrier is dependent on endothelial cell heterotrimeric G‐protein signaling (2002) (46)
- Why are there so many adrenoceptor subtypes? (1994) (46)
- Melatonin Receptors Couple Through a Cholera Toxin‐Sensitive Mechanism to Inhibit Cyclic AMP in the Ovine Pituitary (1995) (45)
- Agonists activate Gi1α or Gi2α fused to the human mu opioid receptor differently (2002) (45)
- Agonist-induced Internalization of the G Protein G11α and Thyrotropin-releasing Hormone Receptors Proceed on Different Time Scales* (1998) (45)
- Measurement of agonist-induced guanine nucleotide turnover by the G-protein Gi1alpha when constrained within an alpha2A-adrenoceptor-Gi1alpha fusion protein. (1997) (45)
- The long isoform of the rat thyrotropin-releasing hormone receptor down-regulates Gq proteins. (1994) (45)
- Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective α1b-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers (2008) (45)
- Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands* (2015) (45)
- β-Arrestin-Dependent Spontaneous α1a-Adrenoceptor Endocytosis Causes Intracellular Transportation of α-Blockers via Recycling Compartmentss⃞ (2005) (44)
- Agonist-induced transfer of the alpha subunits of the guanine-nucleotide-binding regulatory proteins Gq and G11 and of muscarinic m1 acetylcholine receptors from plasma membranes to a light-vesicular membrane fraction. (1994) (44)
- Coordinated agonist regulation of receptor and G protein palmitoylation and functional rescue of palmitoylation-deficient mutants of the G protein G11alpha following fusion to the alpha1b-adrenoreceptor: palmitoylation of G11alpha is not required for interaction with beta*gamma complex. (2001) (44)
- Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs. (2008) (44)
- High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules. (2010) (44)
- Antagonists of GPR35 Display High Species Ortholog Selectivity and Varying Modes of Action (2012) (43)
- Functional Complementation and the Analysis of Opioid Receptor Homodimerization (2005) (43)
- Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade. (1994) (42)
- Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors. (2010) (42)
- Visualization of Agonist-induced Association and Trafficking of Green Fluorescent Protein-tagged Forms of Both β-Arrestin-1 and the Thyrotropin-releasing Hormone Receptor-1* (1999) (42)
- Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization. (2001) (42)
- Indomethacin Treatment Prevents High Fat Diet-induced Obesity and Insulin Resistance but Not Glucose Intolerance in C57BL/6J Mice* (2014) (42)
- Visualizing differences in ligand regulation of wild-type and constitutively active mutant beta(2)-adrenoceptor-green fluorescent protein fusion proteins. (1999) (42)
- G protein–coupled receptor modulation with pepducins: moving closer to the clinic (2011) (42)
- The stoichiometry of expression of protein components of the stimulatory adenylyl cyclase cascade and the regulation of information transfer. (1996) (42)
- Changes in the guanine nucleotide‐binding proteins, Gi and go, during differentiation of 3T3‐L1 cells (1986) (41)
- Altered G-protein expression and adenylate cyclase activity in platelets of non-insulin-dependent diabetic (NIDDM) male subjects. (1991) (41)
- Up‐regulation of a constitutively active form of the β 2‐adrenoceptor by sustained treatment with inverse agonists but not antagonists (1996) (41)
- Selective interactions of mu-opioid receptors with pertussis toxin-sensitive G proteins: involvement of the third intracellular loop and the c-terminal tail in coupling. (1997) (41)
- Opioid receptors and their interacting proteins (2007) (40)
- Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity. (1996) (40)
- The Dynamics of Formation and Action of the Ternary Complex Revealed in Living Cells Using a G-protein-gated K+ Channel as a Biosensor* (2003) (40)
- A general method to quantify ligand-driven oligomerization from fluorescence-based images (2019) (40)
- Glucocorticoids regulate the amount of G proteins in rat aorta. (1990) (40)
- Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development. (1987) (39)
- Multiple pertussis toxin‐sensitive G‐proteins can couple receptors to GIRK channels in rat sympathetic neurons when expressed heterologously, but only native Gi‐proteins do so in situ (2001) (39)
- The other side of opioid receptor signalling: regulation by protein-protein interaction. (2012) (39)
- The human δ opioid receptor activates Gi1α more efficiently than Go1α (2001) (39)
- Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors (2010) (39)
- The specificity and molecular basis of α1-adrenoceptor and CXCR chemokine receptor dimerization (2007) (39)
- Thyrotropin-releasing hormone-induced subcellular redistribution and down-regulation of G11alpha: analysis of agonist regulation of coexpressed G11alpha species variants. (1996) (39)
- G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets (2014) (39)
- Growth Hormone Secretagogues and Growth Hormone Releasing Peptides Act As Orthosteric Super-Agonists but Not Allosteric Regulators for Activation of the G Protein Gαo1 by the Ghrelin Receptor (2009) (39)
- The orexin OX(1) receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands. (2011) (39)
- Immunohistochemical distribution of neurons containing the G-proteins Gqα/G11α in the adult rat brain (1992) (38)
- Analysis of inverse agonism at the delta opioid receptor after expression in Rat 1 fibroblasts. (1996) (38)
- Distribution and relative levels of expression of the phosphoinositidase-C-linked G-proteins Gqα and G11α: Absence of G11α in human platelets and haemopoietically derived cell lines (1993) (38)
- Visualization of distinct patterns of subcellular redistribution of the thyrotropin-releasing hormone receptor-1 and gqalpha /G11alpha induced by agonist stimulation. (1999) (38)
- Gi3 does not contribute to the inhibition of adenylate cyclase when stimulation of an alpha 2-adrenergic receptor causes activation of both Gi2 and Gi3. (1992) (38)
- Ligand‐induced internalization of the orexin OX1 and cannabinoid CB1 receptors assessed via N‐terminal SNAP and CLIP‐tagging (2011) (37)
- G protein-coupled receptor fusion proteins in drug discovery. (2004) (37)
- Gonadotrophin-releasing hormone receptor agonist-mediated down-regulation of Gq alpha/G11 alpha (pertussis toxin-insensitive) G proteins in alpha T3-1 gonadotroph cells reflects increased G protein turnover but not alterations in mRNA levels. (1995) (37)
- The human muscarinic M1 acetylcholine receptor, when expressed in CHO cells, activates and downregulates both Gqα and G11α equally and non‐selectively (1993) (37)
- Characterization of G proteins in rat myometrium A differential modulation of Gi2α and Gi3α during gestation (1991) (37)
- The emerging pharmacology and function of GPR35 in the nervous system (2017) (36)
- Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs* (2016) (36)
- Ligand regulation of green fluorescent protein-tagged forms of the human beta(1)- and beta(2)-adrenoceptors; comparisons with the unmodified receptors. (2000) (36)
- Periplakin Interferes with G Protein Activation by the Melanin-concentrating Hormone Receptor-1 by Binding to the Proximal Segment of the Receptor C-terminal Tail* (2005) (36)
- Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides (1986) (36)
- Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer. (2016) (36)
- G-proteins in experimental hypertension: a study of spontaneously hypertensive rat myocardial and renal cortical plasma membranes (1993) (36)
- The palmitoylation status of the G-protein G(o)1 alpha regulates its activity of interaction with the plasma membrane. (1994) (36)
- Measurement of agonist efficacy using an α2A‐adrenoceptor‐Gi1α fusion protein (1997) (35)
- The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane. (1995) (35)
- GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini. (1987) (35)
- Guanine nucleotide regulatory protein levels and function in spontaneously hypertensive rat vascular smooth-muscle cells. (1992) (35)
- Degradation of G/G Is Accelerated by Agonist Occupancy of , , and Adrenergic Receptors (*) (1995) (35)
- G-proteins as mediators of cellular signalling processes (1990) (35)
- GTP analogues cause release of the alpha subunit of the GTP binding protein, GO, from the plasma membrane of NG108-15 cells. (1988) (35)
- Eukaryotic Translation Initiation Factor 3, Subunit a, Regulates the Extracellular Signal-Regulated Kinase Pathway (2011) (35)
- Agonist regulation of cellular Gs alpha-subunit levels in neuroblastoma x glioma hybrid NG108-15 cells transfected to express different levels of the human beta 2 adrenoceptor. (1994) (35)
- Regulation of G Protein Activation and Effector Modulation by Fusion Proteins between the Human 5-Hydroxytryptamine1AReceptor and the α Subunit of Gi1α: Differences in Receptor-Constitutive Activity Imparted by Single Amino Acid Substitutions in Gi1α (1999) (35)
- Chemical inhibition of myristoylation of the G-protein Gi1 alpha by 2-hydroxymyristate does not interfere with its palmitoylation or membrane association. Evidence that palmitoylation, but not myristoylation, regulates membrane attachment. (1996) (35)
- Chemogenetics defines receptor-mediated functions of short chain free fatty acids (2019) (34)
- Modulation of relative intrinsic activity of agonists at the alpha-2A adrenoceptor by mutation of residue 351 of G protein gi1alpha. (1999) (34)
- Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease (1993) (33)
- Structural and biophysical characterisation of G protein-coupled receptor ligand binding using resonance energy transfer and fluorescent labelling techniques. (2014) (33)
- CypHer 5: a generic approach for measuring the activation and trafficking of G protein-coupled receptors in live cells. (2003) (33)
- Immunoprecipitation of opioid receptor-Go-protein complexes using specific GTP-binding-protein antisera. (1995) (33)
- Effective Information Transfer from the α1b-Adrenoceptor to Gα11 Requires Both β/γ Interactions and an Aromatic Group Four Amino Acids from the C Terminus of the G Protein* (2002) (32)
- High-Throughput Identification and Characterization of Novel, Species-selective GPR35 Agonists (2013) (32)
- G-proteins in essential hypertension: a study of human platelet plasma membranes (1993) (31)
- Differential capacities of the RGS1, RGS16 and RGS–GAIP regulators of G protein signaling to enhance α2A‐adrenoreceptor agonist‐stimulated GTPase activity of Go1α (2001) (31)
- Guanine nucleotide regulatory proteins in the spontaneously hypertensive rat. (1993) (31)
- The three α1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation. (2013) (31)
- Minireview: The Effects of Species Ortholog and SNP Variation on Receptors for Free Fatty Acids (2013) (31)
- Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese (fa/fa) Zucker rats. (1991) (30)
- Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase. (1997) (30)
- A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor. (2016) (30)
- Differential uncoupling of A1 adenosine and D2 dopamine receptors by suramin and didemethylated suramin (NF037). (1998) (30)
- Interaction of Neurochondrin with the Melanin-concentrating Hormone Receptor 1 Interferes with G Protein-coupled Signal Transduction but Not Agonist-mediated Internalization* (2006) (30)
- Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 (2017) (29)
- Concurrent up-regulation of guanine-nucleotide-binding proteins Gi1α, Gi2α and Gi3α in adipocytes of hypothyroid rats (1990) (29)
- Inverse agonism at adrenergic and opioid receptors: studies with wild type and constitutively active mutant receptors. (1997) (29)
- Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition (2018) (29)
- Opioid peptides promote cholera-toxin-catalysed ADP-ribosylation of the inhibitory guanine-nucleotide-binding protein (Gi) in membranes of neuroblastoma x glioma hybrid cells. (1988) (29)
- Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2. (2014) (29)
- The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs. (2013) (28)
- Differential G‐protein expression during B‐ and T‐cell development (1997) (28)
- Therapeutic Opportunities and Challenges in Targeting the Orphan G Protein-Coupled Receptor GPR35 (2020) (28)
- GTP analogues promote release of the alpha subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells. (1988) (27)
- Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance (2017) (27)
- Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi. (1988) (27)
- Expression of Gsα, Connexin-43, Connexin-26, and EP1, 3, and 4 Receptors in Myometrium of Prelabor Singleton Versus Multiple Gestations and the Effects of Mechanical Stretch and Steroids on Gsα (2002) (27)
- Characterization of the gonadotrophin-releasing hormone receptor in alpha T3-1 pituitary gonadotroph cells. (1993) (27)
- New Aspects of G-Protein-Coupled Receptor Signalling and Regulation (1998) (27)
- Abundance of the alpha-subunits of Gi1, Gi2 and Go in synaptosomal membranes from several regions of the rat brain is increased in hypothyroidism. (1991) (27)
- Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43). (2017) (27)
- High-affinity interactions between human alpha1A-adrenoceptor C-terminal splice variants produce homo- and heterodimers but do not generate the alpha1L-adrenoceptor. (2004) (26)
- Enhanced detection of receptor constitutive activity in the presence of regulators of G protein signaling: applications to the detection and analysis of inverse agonists and low-efficacy partial agonists. (2002) (26)
- Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line. (1988) (26)
- Receptors as Kissing Cousins (2000) (26)
- Analysis of agonist function at fusion proteins between the IP prostanoid receptor and cognate, unnatural and chimaeric G-proteins. (1999) (26)
- Strategies to identify ligands for orphan G-protein-coupled receptors. (2001) (26)
- Resolution of inverse agonist-induced up-regulation from constitutive activity of mutants of the alpha(1b)-adrenoceptor. (2000) (26)
- Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4 (2017) (26)
- A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. (1996) (25)
- Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function. (1989) (25)
- Ligands at the Free Fatty Acid Receptors 2/3 (GPR43/GPR41). (2017) (25)
- Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation (2017) (25)
- Genome Editing Provides New Insights into Receptor-Controlled Signalling Pathways. (2018) (25)
- Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3 (2019) (25)
- Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells. (1994) (25)
- Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go. (1993) (25)
- Carvedilol-induced antagonism of angiotensin II: a matter of α1-adrenoceptor blockade (2004) (25)
- Regulation of cardiac adenylate cyclase activity in rodent models of obesity. (1992) (25)
- Chimaeric G alpha proteins: their potential use in drug discovery. (1999) (25)
- Signal sorting by G-protein-linked receptors. (1995) (24)
- δ‐Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains (2003) (24)
- Antibodies that identify only the active conformation of Gi family G protein α subunits (2008) (24)
- Beta-arrestin-dependent spontaneous alpha1a-adrenoceptor endocytosis causes intracellular transportation of alpha-blockers via recycling compartments. (2005) (24)
- Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor (2017) (24)
- Measurement of Agonist-Dependent and -Independent Signal Initiation of α1b-Adrenoceptor Mutants by Direct Analysis of Guanine Nucleotide Exchange on the G Protein Gα11 (2002) (24)
- μ-δ Opioid Receptor Functional Interaction: Insight Using Receptor-G Protein Fusions (2006) (24)
- Functional analysis of a human A1 adenosine receptor/green fluorescent protein/Gi1α fusion protein following stable expression in CHO cells (1999) (23)
- Analysis of Human Dopamine D3 Receptor Quaternary Structure* (2015) (23)
- S 14506: novel receptor coupling at 5-HT1A receptors (2001) (23)
- Elevated levels of the guanine nucleotide binding protein, Go, are associated with differentiation of neuroblastoma × glioma hybrid cells (1989) (23)
- A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex. (1997) (23)
- Novel pharmacological applications of G-protein-coupled receptor-G protein fusions. (2007) (23)
- Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat. (1987) (23)
- Metabolic and inflammatory functions of short-chain fatty acid receptors (2020) (23)
- G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation (2016) (23)
- Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. (2018) (22)
- Interaction of the G‐protein G11α with receptors and phosphoinositidase C: (1997) (22)
- Kinetic analysis of the internalization and recycling of [3H]TRH and C-terminal truncations of the long isoform of the rat thyrotropin-releasing hormone receptor-1. (2000) (22)
- Identification of both Gi2 and a novel, immunologically distinct, form of Go in rat myometrial membranes (1989) (22)
- Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35 (2018) (22)
- Involvement of G‐protein αil subunits in activation of G‐protein gated inward rectifying K+ channels (GIRK1) by human NPY1 receptors (1995) (22)
- Action of Pasteurella multocida toxin on Galpha(q) is persistent and independent of interaction with G-protein-coupled receptors. (2007) (22)
- Analysis of endogenous S1P and LPA receptor expression in CHO-K1 cells. (2005) (21)
- Control of the efficiency of agonist-induced information transfer and stability of the ternary complex containing the δ opioid receptor and the α subunit of Gi1 by mutation of a receptor/G protein contact interface (2001) (21)
- Generation and analysis of constitutively active and physically destabilized mutants of the human beta(1)-adrenoceptor. (2002) (21)
- Detection of receptor ligands by monitoring selective stabilization of a Renilla luciferase‐tagged, constitutively active mutant, G‐protein‐coupled receptor (2001) (21)
- A single amino acid determines preference between phospholipids and reveals length restriction for activation ofthe S1P4 receptor (2004) (21)
- Selectivity and functional consequences of interactions of family A G protein‐coupled receptors with neurochondrin and periplakin (2009) (21)
- Beta 3-adrenoceptor agonist-induced down-regulation of Gs alpha and functional desensitization in a Chinese hamster ovary cell line expressing a beta 3-adrenoceptor refractory to down-regulation. (1994) (21)
- The turkey erythrocyte beta-adrenergic receptor couples to both adenylate cyclase and phospholipase C via distinct G-protein alpha subunits. (1994) (21)
- The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha. (2000) (21)
- Thyrotropin‐releasing hormone‐induced depletion of Gqα/G11α proteins from detergent‐insensitive membrane domains (1999) (21)
- Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX1 and OX2 Receptors Identify Slow Kinetics of Agonist Activation* (2012) (21)
- G-proteins : signal transduction and disease (1992) (20)
- G protein‐coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35 (2017) (20)
- Differential distribution of signal-transducing G-proteins in retina (1987) (20)
- GPCR oligomerization and receptor trafficking. (2013) (20)
- The α2 B adrenergic receptor of undifferentiated neuroblastoma × glioma hybrid NG108‐15 cells, interacts directly with the guanine nucleotide binding protein, Gi2 (1990) (20)
- Guanine nucleotide-binding proteins and cellular control. (1989) (20)
- Chronic exposure of rat glioma C6 cells to cholera toxin induces loss of the alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gs). (1990) (20)
- Therapeutic validation of an orphan G protein‐coupled receptor: The case of GPR84 (2020) (20)
- Efficacy of inverse agonists in cells overexpressing a constitutively active β2‐adrenoceptor and type II adenylyl cyclase (1998) (20)
- The Orphan Receptor GPR35 Contributes to Angiotensin II–Induced Hypertension and Cardiac Dysfunction in Mice (2018) (19)
- Immunological identification of the α subunit of G13, a novel guanine nucleotide binding protein (1992) (19)
- Foetal-calf serum stimulates a pertussis-toxin-sensitive high-affinity GTPase activity in rat glioma C6 BU1 cells. (1987) (19)
- Guanine nucleotide regulatory protein alterations in the Milan hypertensive rat strain (1993) (19)
- Degradation of G11 alpha/Gq alpha is accelerated by agonist occupancy of alpha 1A/D, alpha 1B, and alpha 1C adrenergic receptors. (1995) (19)
- Regional distribution and quantitative measurement of the phosphoinositidase C-linked guanine nucleotide binding proteins G11 alpha and Gq alpha in rat brain. (1993) (19)
- Co‐expression of mu and delta opioid receptors as receptor‐G protein fusions enhances both mu and delta signalling via distinct mechanisms (2008) (19)
- A Key Serine for the GTPase-Activating Protein Function of Regulator of G Protein Signaling Proteins Is Not a General Target for 14-3-3 Interactions (2005) (19)
- Regulation of cardiovascular remodeling by the counter-regulatory axis of the renin-angiotensin system. (2013) (19)
- Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells. (1987) (19)
- Cold-induced reduction in Gi alpha proteins in brown adipose tissue. Effects on the cellular hypersensitization to noradrenaline caused by pertussis-toxin treatment. (1996) (19)
- Analysis of inverse agonism at the δ opioid receptor after expression in Rat 1 fibroblasts (1996) (18)
- Ligand Rescue of Constitutively Active Mutant Receptors (2002) (18)
- Dominant portion of thyrotropin-releasing hormone receptor is excluded from lipid domains. Detergent-resistant and detergent-sensitive pools of TRH receptor and Gqalpha/G11alpha protein. (2005) (18)
- Interactions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation. (2004) (18)
- Guanine-nucleotide-binding proteins Gi and Gs in fat-cells from normal, hypothyroid and obese human subjects. (1989) (18)
- Construction and analysis of function of G protein-coupled receptor-G protein fusion proteins. (2002) (17)
- Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS). (1990) (17)
- Immunohistochemical distribution of neurons containing the G-proteins Gq alpha/G11 alpha in the adult rat brain. (1992) (17)
- Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon. (1989) (17)
- The use of receptor G-protein fusion proteins for the study of ligand activity. (2002) (17)
- Novel mutation in the AVPR2 gene in a Danish male with nephrogenic diabetes insipidus caused by ER retention and subsequent lysosomal degradation of the mutant receptor (2011) (17)
- MicroRNAs regulating cell pluripotency and vascular differentiation. (2011) (17)
- Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy. (2016) (17)
- Loss of activation of Gs but not Gi following expression of an α2A‐adrenoceptor‐Gi1α fusion protein (1998) (17)
- Discovery of 9-cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial. (2020) (17)
- Dynamic protein acylation and the regulation of localization and function of signal-transducing proteins. (1995) (17)
- MicroRNA regulation of endothelial homeostasis and commitment-implications for vascular regeneration strategies using stem cell therapies. (2013) (17)
- The Molecular Basis of Oligomeric Organization of the Human M3 Muscarinic Acetylcholine Receptor (2015) (17)
- Immunological characterization of the guanine-nucleotide binding proteins Gi and Go in rat islets of Langerhans. (1992) (17)
- G-protein palmitoylation: regulation and functional significance. (1995) (17)
- Molecular interaction of the human alpha 2-C10-adrenergic receptor, when expressed in Rat-1 fibroblasts, with multiple pertussis toxin-sensitive guanine nucleotide-binding proteins: studies with site-directed antisera. (1991) (16)
- A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization (2017) (16)
- Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation (2019) (15)
- The Dually Acylated NH2-terminal Domain of Gi1α Is Sufficient to Target a Green Fluorescent Protein Reporter to Caveolin-enriched Plasma Membrane Domains (1999) (15)
- Differences in the Signaling Pathways of α1A- and α1B-Adrenoceptors Are Related to Different Endosomal Targeting (2013) (15)
- Expression of Gsalpha, connexin-43, connexin-26, and EP1, 3, and 4 receptors in myometrium of prelabor singleton versus multiple gestations and the effects of mechanical stretch and steroids on Gsalpha. (2002) (15)
- Concerted stimulation and deactivation of pertussis toxin‐sensitive G proteins by chimeric G protein‐coupled receptor‐regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity of RGS4 (2003) (15)
- Expression of the Human β2‐Adrenoceptor in NCB20 Cells Results in Agonist Activation of Adenylyl Cyclase and Agonist‐Mediated Selective Down‐Regulation of Gsα (1995) (15)
- Activation of an α2A-adrenoceptor–Gαo1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor (2005) (15)
- On-target and off-target effects of novel orthosteric and allosteric activators of GPR84 (2019) (15)
- Effects of dexamethasone on G protein levels and adenylyl cyclase activity in rat vascular smooth muscle cells. (1992) (15)
- Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently. (2002) (15)
- Long-term agonist stimulation of IP prostanoid receptor depletes the cognate G(s)alpha protein in membrane domains but does not change the receptor level. (2004) (15)
- Pathophysiological regulation of lung function by the free fatty acid receptor FFA4 (2020) (14)
- Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells. (2010) (14)
- G protein-coupled receptors : structure, signaling, and physiology (2010) (14)
- A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias (2017) (14)
- An Asp79Asn mutation of the α2A‐adrenoceptor interferes equally with agonist activation of individual Giα‐family G protein subtypes (1999) (14)
- Mechanisms of agonist-induced G-protein elimination. (1995) (13)
- Quantitative analysis of a cysteine351glycine mutation in the G protein Gi1α: effect on α2A‐adrenoceptor‐Gi1α fusion protein activation (1998) (13)
- Treatment with triiodothyronine decreases the abundance of the α-subunits of Gi1 and Gi2 in the cerebral cortex (1992) (13)
- Ligand specific up-regulation of a Renilla reniformis luciferase-tagged, structurally unstable muscarinic M3 chimeric G protein-coupled receptor. (2003) (13)
- G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis (2021) (13)
- The pharmacology of a potent and selective agonist , TUG-891 , demonstrates both potential opportunity and possible challenges to therapeutic agonism of FFA 4 ( GPR 120 ) (2013) (13)
- Widespread distribution of Gq alpha/G11 alpha detected immunologically by an antipeptide antiserum directed against the predicted C-terminal decapeptide. (1991) (13)
- The use of anti-peptide antisera to probe interactions between receptors and guanine nucleotide binding proteins. (1988) (12)
- Mechanism of Action of Gq to Inhibit Gβγ Modulation of CaV2.2 Calcium Channels: Probed by the Use of Receptor-Gα Tandems (2003) (12)
- [21] Specificity and functional applications of antipeptide antisera which identify G-protein α subunits (1994) (12)
- How do G-proteins stay at the plasma membrane? (1997) (12)
- Muscarinic receptor oligomerization (2017) (12)
- Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment (2013) (12)
- The use of specific antibodies to identify and quantify guanine nucleotide-binding proteins. (1987) (12)
- Selectivity in the oligomerisation of G protein-coupled receptors. (2004) (12)
- Detection and analysis of agonist-induced formation of the complex of the stimulatory guanine nucleotide-binding protein with adenylate cyclase in intact wild-type and beta 2-adrenoceptor-expressing NG108-15 cells. (1995) (12)
- Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor. (1997) (12)
- Opioid regulation of mu receptor internalisation: relevance to the development of tolerance and dependence. (2010) (12)
- Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors. (2017) (12)
- Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and alpha 2C10 adrenoceptor-transfected Rat 1 fibroblasts. (1994) (12)
- Overexpression of Gsα in NG108‐15, neuroblastoma X glioma cells: effects on receptor regulation of the stimulatory adenylyl cyclase cascade (1996) (12)
- Functional control of the δ-opiate receptor by the inhibitory guanine nucleotide-binding protein (1985) (11)
- Altering the Relative Stoichiometry of Receptors, G Proteins and Effectors: Effects on Agonist Function (2000) (11)
- Guanine nucleotide regulatory protein alterations in young Milan hypertensive strain rats. (1994) (11)
- Heterodimerisation of G protein-coupled receptors: implications for drug design and ligand screening (2010) (11)
- Comparison of the signalling properties of the long and short isoforms of the rat thyrotropin-releasing-hormone receptor following expression in rat 1 fibroblasts. (1995) (11)
- Stimulus-response coupling in FMLP-stimulated U937 monocytes: effect of differentiation on Gi2 expression. (1990) (11)
- The novel antidepressant, S35966, is a mixed serotonin and noradrenaline reuptake inhibitor and an antagonist at α2-adrenoceptors (2002) (11)
- GPCR Theme Editorial (2009) (11)
- Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. (2017) (11)
- Activation, cellular redistribution and enhanced degradation of the G proteins Gq and G11 by endogenously expressed and transfected phospholipase C-coupled muscarinic m1 acetylcholine receptors. (1996) (11)
- Selective activation of a chimeric Gi1/Gs G protein alpha subunit by the human IP prostanoid receptor: analysis using agonist stimulation of high affinity GTPase activity and [35S]guanosine-5'-O-(3-thio)triphosphate binding. (1998) (11)
- Regulation of the stoichiometry of protein components of the stimulatory adenylyl cyclase cascade. (1998) (10)
- Tissue distribution and subcellular location of guanine nucleotide binding proteins: implications for cellular signalling. (1989) (10)
- Apparent down-regulation of muscarinic acetylcholine receptors of neuroblastoma cells by pilocarpine is due to occluded agonist. (1983) (10)
- FFA 4 / GPR 120 : Pharmacology and Therapeutic Opportunities (2017) (10)
- The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding. (1989) (10)
- Equivalent regulation of wild type and an epitope‐tagged variant of Gsα by the IP prostanoid receptor following expression in neuroblastoma × glioma hybrid, NG108‐15, cells (1994) (10)
- Structural Characterization of Agonist Binding to Protease-Activated Receptor 2 through Mutagenesis and Computational Modeling. (2018) (10)
- Identification of Three Residues Essential for 5-HT 2 A-mGlu 2 Receptor Heteromerization and its Psychoactive Behavioral Function (2012) (10)
- Binding to GDP-agarose identifies a novel 60kDa substrate for the insulin receptor tyrosyl kinase in mouse NIH-3T3 cells expressing high concentrations of the human insulin receptor. (1989) (10)
- Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein–Coupled Receptors (2018) (10)
- The human muscarinic M1 acetylcholine receptor, when express in CHO cells, activates and downregulates both Gq alpha and G11 alpha equally and non-selectively. (1993) (10)
- Regulation of p42 and p44 Map Kinase Isoforms in Rat-1 Fibroblasts Stably Transfected with α2C10 Adrenoceptors (1994) (10)
- Guanine nucleotide binding proteins in neuroblastoma x glioma hybrid, NG108-15, cells. Regulation of expression and function. (1990) (10)
- Dimerization of α1-adrenoceptors (2004) (9)
- Use of [3H]Triphenylmethylphosphomum Cation for Estimating Membrane Potential in Neuroblastoma Cells (1984) (9)
- Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients. (1989) (9)
- The role and specificity of guanine nucleotide binding proteins in receptor-effector coupling. (1990) (9)
- Constitutive activity of GPR40/FFA1 intrinsic or assay dependent? (2010) (9)
- Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor (2022) (9)
- A constitutively active mutant of the alpha 1B-adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins G9 alpha and G11 alpha than the wild-type receptor. (1996) (9)
- Agonist Occupation of an α2A-Adrenoreceptor-Gi1α Fusion Protein Results in Activation of Both Receptor-linked and Endogenous Gi Proteins (1998) (9)
- Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism. (1989) (9)
- Approaches to Characterize and Quantify Oligomerization of GPCRs. (2015) (8)
- Analysis of function of receptor-G-protein and receptor-RGS fusion proteins. (2004) (8)
- The use of biochemical methods for estimating membrane potential. (1982) (8)
- Distinct Agonist Regulation of Muscarinic Acetylcholine M2-M3 Heteromers and Their Corresponding Homomers* (2015) (8)
- Characterization of G proteins in rat myometrium. A differential modulation of Gi2 alpha and Gi3 alpha during gestation. (1991) (8)
- Oligomeric structure of the α1b-adrenoceptor: Comparisons with rhodopsin (2006) (8)
- Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha. (2001) (8)
- G protein-coupled receptors not currently in the spotlight : free fatty acid receptor 2 and GPR 35 (2017) (8)
- Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels. (1991) (8)
- Reciprocal mutations of highly conserved residues in transmembrane helices 2 and 7 of the α2A-adrenoceptor restore agonist activation of Gi1α (2002) (8)
- Signal transduction : a practical approach (1992) (8)
- Functional interactions between the α1b-adrenoceptor and Gα11 are compromised by de-palmitoylation of the G protein but not of the receptor (2006) (8)
- Muscarinic Acetylcholine Receptors in Neuroblastoma Cells: Lack of Effect of Veratrum Alkaloids on Receptor Number (1984) (8)
- Thyrotropin-releasing hormone-induced depletion of G(q)alpha/G(11)alpha proteins from detergent-insensitive membrane domains. (1999) (8)
- Increased concentrations of proteins Gi1 and Gi2 in adipocytes from aged rats alter the sensitivity of adenylyl cyclase to inhibitory and stimulatory agonists. (1995) (7)
- University of Southern Denmark Activity of dietary fatty acids on FFA 1 and FFA 4 and characterisation of pinolenic acid as a dual FFA 1 / FFA 4 agonist with potential effect against metabolic diseases (2015) (7)
- Chemogenetics defines a short-chain fatty acid receptor gut–brain axis (2022) (7)
- Dimerization of alpha1-adrenoceptors. (2004) (7)
- Effects of prolonged treatment of adipocytes with PGE1, N6-phenylisopropyl adenosine and nicotinic acid on G-proteins and antilipolytic sensitivity. (1991) (7)
- áágg dimers derived from both G 0 and G 1 G protein heterotrimers contribute different components of à 2 -adrenoceptor mediated inhibition of Ca 2+ channels in rat sympathetic neurones (1999) (7)
- Selective phosphorylation of threonine residues defines GPR84–arrestin interactions of biased ligands (2022) (7)
- G-Protein-Coupled Receptor Dimers (2017) (7)
- Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association. (1997) (7)
- Diversity in the signalling and regulation of G-protein-coupled receptors. (1999) (7)
- Reduction of adenylyl cyclase activity by cholera toxin in myeloid cells (1990) (7)
- Erratum: Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi in diabetes (Nature (1987) 327, (229-232) (1987) (7)
- Agonist regulation of cellular levels of the stimulatory guanine nucleotide-binding protein, Gs, in wild type and transfected neuroblastoma-glioma hybrid NG108-15 cells. (1993) (7)
- Is Promiscuity of G Protein Interaction an Issue in the Classification of Receptors? (1997) (7)
- Specificity of interactions of receptors and effectors with GTP-binding proteins in native membranes. (1990) (7)
- Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. (2010) (7)
- Activation of an alpha2A-adrenoceptor-Galphao1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor. (2005) (7)
- Engineering a V(2) vasopressin receptor agonist- and regulator of G-protein-signaling-sensitive G protein. (2002) (7)
- Structure–Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators (2020) (6)
- Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression (2008) (6)
- Distribution and relative levels of expression of the phosphoinositidase-C-linked G-proteins Gq alpha and G11 alpha: absence of G11 alpha in human platelets and haemopoietically derived cell lines. (1993) (6)
- Cyclic AMP differentially regulates the expression of the alpha-subunits of Gs, Gq and G11 G-proteins and their mRNA levels in rat C6 glioma cells. (1995) (6)
- Autoimmune Disease-Associated Histamine Receptor H1 Alleles Exhibit Differential Protein Trafficking and Cell Surface Expression1 (2008) (6)
- Mechanism of action of Gq to inhibit G beta gamma modulation of CaV2.2 calcium channels: probed by the use of receptor-G alpha tandems. (2003) (6)
- Reciprocal mutations of highly conserved residues in transmembrane helices 2 and 7 of the alpha(2A)-adrenoceptor restore agonist activation of G(i1)alpha. (2002) (6)
- Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease (2021) (6)
- Identification of a Novel Serotonin / Glutamate Receptor Complex Implicated in Psychosis (2009) (6)
- Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts. (1995) (6)
- Prostanoid-mediated downregulation of Gs in NG108-15 cells. (1991) (6)
- The Role of miRNA in Stem Cell Pluripotency and Commitment to the Vascular Endothelial Lineage (2012) (6)
- Biochemical estimation of membrane potential in neuroblastoma cells (1981) (6)
- The effect of sodium channel activators on muscarinic receptors of neuroblastoma cells (1982) (6)
- Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84 (2021) (6)
- Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t (2020) (6)
- Stochastic multidimensional hypercubes and inverse agonism. (2000) (6)
- Effective information transfer from the alpha 1b-adrenoceptor to Galpha 11 requires both beta/gamma interactions and an aromatic group four amino acids from the C terminus of the G protein. (2002) (6)
- Defining the organizational structure of dopamine and muscarninic acetylcholine receptors (2015) (6)
- Analysis of Pertussis Toxin-Sensitive Receptor: G-Protein Interactions in Native Porcine Endothelial Cells (1995) (6)
- An arginine residue is the site of receptor-stimulated, cholera toxin-catalysed ADP-ribosylation of pertussis toxin-sensitive G-proteins. (1993) (5)
- Reduction in accumulation of [3H]triphenylmethylphosphonium cation in neuroblastoma cells caused by optical probes of membrane potential. Evidence for interactions between carbocyanine dyes and lipophilic anions. (1983) (5)
- Regulation of the avidity of ternary complexes containing the human 5‐HT1A receptor by mutation of a receptor contact site on the interacting G protein α subunit (2002) (5)
- Functional interactions between the alpha1b-adrenoceptor and Galpha11 are compromised by de-palmitoylation of the G protein but not of the receptor. (2006) (5)
- Regulation of G protein activation and effector modulation by fusion proteins between the human 5-hydroxytryptamine(1A) receptor and the alpha subunit of G(i1): differences in receptor-constitutive activity imparted by single amino acid substitutions in G(i1)alpha. (1999) (5)
- Multiple heterotrimeric guanine nucleotide binding proteins: roles in the determination of cellular signalling specificity. (1992) (5)
- Free Fatty Acid Receptors (2017) (5)
- Allosteric modulation and constitutive activity of fusion proteins between the adenosine A1 receptor and different 351Cys-mutated Gi alpha-subunits. (2004) (5)
- Coordinated agonist regulation of receptor and G protein palmitoylation and functional rescue of palmitoylation-deficient mutants of the G protein G(11)alpha following fusion to the alpha(1b)-adrenoreceptor - Palmitoylation of G(11 alpha) is not required (2001) (5)
- G protein activation and effector regulation by the human 5-HT1A receptor and the α subunit of Gi1 fusion proteins (1999) (5)
- Chapter 10. Hetero-oligomerization of chemokine receptors. (2009) (5)
- Loss of activation of Gs but not Gi following expression of an alpha2A-adrenoceptor-Gi1alpha fusion protein. (1998) (5)
- Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi in diabetes (1987) (5)
- Foetal calf serum enhances cholera toxin-catalysed ADP-ribosylation of the pertussis toxin-sensitive guanine nucleotide binding protein, Gi2, in rat glioma C6BU1 cells. (1989) (5)
- Chemogenetic Approaches to Explore the Functions of Free Fatty Acid Receptor 2. (2021) (4)
- Down-regulation of the alpha-subunits of Gi subtypes by prolonged incubation of adipocytes with N6-phenylisopropyl adenosine. (1990) (4)
- The role of adenyl cyclase in opiate tolerance and dependence. (1984) (4)
- Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein. (1997) (4)
- Chapter 6:Ligand Regulation of GPCR Quaternary Structure (2011) (4)
- Chapter 24. Oligomerisation of G protein-coupled receptors (2000) (4)
- M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes. (2017) (4)
- Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA 2 free fatty acid (2013) (4)
- The Use of Spatial Intensity Distribution Analysis to Examine G Protein-Coupled Receptor Oligomerization (2017) (4)
- Angiotensin-( 1-7 ) and angiotensin-( 1-9 ) : function in cardiac and vascular remodeling (2014) (4)
- Concurrent specific immunological detection of both primate and rodent forms of the guanine nucleotide binding protein G11 alpha following their coexpression. (1994) (4)
- Syddansk Universitet Complex Pharmacology of Free Fatty Acid Receptors (2017) (4)
- G-proteins of rat liver membranes. Subcellular compartmentation and disposition in the plasma membrane (2004) (4)
- Endocrine disorders associated with mutations in guanine nucleotide binding proteins. (1996) (4)
- Coordinated Agonist Regulation of Receptor and G Protein Palmitoylation and Functional Rescue of Palmitoylation-deficient Mutants of the G Protein G11α following Fusion to the α1b-Adrenoreceptor (2001) (4)
- Immunological identification of the alpha subunit of G13, a novel guanine nucleotide binding protein. (1992) (4)
- b-Opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gj 2 (4)
- Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity. (2008) (4)
- Differential Uncoupling of A 1 Adenosine and D 2 Dopamine Receptors by Suramin and Didemethylated Suramin ( NF 037 ) (1998) (4)
- The β subunit of the guanine nucleotide regulatory proteins: Identification of its location on two‐dimesional gels of brain tissue and its regional and subcellular distribution in brain (1986) (4)
- An Asp79Asn mutation of the alpha2A-adrenoceptor interferes equally with agonist activation of individual Gialpha-family G protein subtypes. (1999) (4)
- Investigating the Structure–Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists (2022) (3)
- Oligomeric structure of the alpha1b-adrenoceptor: comparisons with rhodopsin. (2006) (3)
- Defining the functional equivalence of wild-type and chemically engineered G protein-coupled receptors (2015) (3)
- Biochemical approaches to examine the specificity of interactions between receptors and guanine nuclotide binding proteins. (1995) (3)
- Visualization of distinct patterns of subcellular redistribution of the thyrotropin-releasing hormone receptor-1 and G q a /G 11 a induced by agonist stimulation (1999) (3)
- Characterization of heterotrimeric G-proteins in adult Acanthocheilonema viteae. (1996) (3)
- Identification and Analysis of Function of Heterotrimeric Guanine Nucleotide-Binding Proteins Expressed in Neural Tissue (1992) (3)
- G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes (2021) (3)
- Palmitoylation negative mutants of murine G11 alpha have decreased ability to interact with the plasma membrane when expressed in COS-1 cells. (1995) (3)
- Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses (2020) (3)
- Regulation of p42 and p44 MAP kinase isoforms in Rat-1 fibroblasts stably transfected with alpha 2C10 adrenoreceptors. (1994) (3)
- Angiotensin-(1-9) antagonises cardiac remodelling via the angiotensin type 2 receptor (2013) (3)
- Receptor availability defines the extent of agonist‐mediated G‐protein down‐regulation in neuroblastoma × glioma hybrid cells transfected to express the β2‐adrenoceptor (1994) (3)
- Qualitative and quantitative characterization of the distribution of G-protein α subunits in mammals (1993) (3)
- 178 Angiotensin-(1–9) inhibits vascular smooth muscle cell proliferation and migration in vitro and neointimal formation in vivo (2015) (3)
- Concurrent up-regulation of guanine-nucleotide-binding proteins Gi1 alpha, Gi2 alpha and Gi3 alpha in adipocytes of hypothyroid rats. (1990) (3)
- Quantitative analysis of a cysteine351glycine mutation in the G protein Gi1alpha: effect on alpha2A-adrenoceptor-Gi1alpha fusion protein activation. (1998) (3)
- Neurobiology. Receptors as kissing cousins. (2000) (3)
- The First 50 Years of Molecular Pharmacology (2015) (3)
- Capillary electrophoresis assay for G protein-coupled receptor-mediated GTPase activity. (2007) (3)
- Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis (2022) (2)
- Agonist activation of transfected human M1 muscarinic acetylcholine receptor in Chinese hamster ovary cells results in concurrent downregulation of Gq alpha and G11 alpha. (1993) (2)
- Overexpression of G(s)alpha in NG108-15, neuroblastomaXglioma cells: effects on receptor regulation of the stimulatory adenylyl cyclase cascade. (1996) (2)
- TNF alpha regulation of proteinase activated receptor-2 and -4 heterodimerisation (2008) (2)
- Abstract 307: GPR120/FFAR4 activation by fatty acid 16:4(n-3) plays a key role in resistance to chemotherapy (2016) (2)
- Distinct phosphorylation clusters determine the signalling outcome of the free fatty acid receptor FFA 4 / GPR 120 (2016) (2)
- Enhanced degradation of the phosphoinositidase Clinked guanine-nucleotide-binding protein GqcX / GijaX following activation of the human Ml muscarinic acetylcholine receptor expressed in CHO cells (2005) (2)
- Functional control of the delta-opiate receptor by the inhibitory guanine nucleotide-binding protein. (1985) (2)
- Inverse agonism at G protein-coupled receptors. Studies with wild type and mutated adrenergic and opioid receptors (1998) (2)
- Activation of the gonadotropin releasing hormone receptor of αT3 cells results in downregulation of the α subunits of both Gq/G11 (1993) (2)
- The Use of Specific Antisera to Locate Functional Domains of Guanine Nucleotide Binding Proteins (1989) (2)
- Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes. (1990) (2)
- Phosphorylation of Gi in intact cells. (1990) (2)
- Lack of N terminal palmitoylation of G protein α sub-units reduces membrane association (1993) (2)
- Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis (2020) (2)
- Identification and Quantitation of G Protein α-Subunits (1997) (2)
- EMBRYONIC STEM CELLS / INDUCED PLURIPOTENT STEM CELLS Role of MicroRNAs 99 b , 181 a , and 181 b in the Differentiation of Human Embryonic Stem Cells to Vascular Endothelial Cells (2012) (2)
- Agonist-Mediated Turnover of G-Protein α-Subunit Palmitoyl Groups (1998) (2)
- Dimerization of alpha(1)-adrenoceptors (2004) (2)
- Novel Assay Technologies for the Discovery of G Protein-Coupled Receptor Drugs (2011) (2)
- G protein-coupled receptors: oligomerisation and association with accessory proteins. (2004) (2)
- Free fatty acid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (2)
- Agonist activation of transfected human M1 muscarinic acetylcholine receptor in Chinese hamster ovary cells results in concurrent downregulation of Gqα and G11α (1993) (2)
- Fatty airways: a source of good and bad fats? (2019) (2)
- Generation and Analysis of Constitutively Active and Physically Destabilized Mutants of the Human (cid:1) 1 -Adrenoceptor (2002) (2)
- The GTP‐binding regulatory proteins of neuroblastoma × glioma, NG108‐15, and glioma, C6, cells (2001) (1)
- Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. (2020) (1)
- Structure‐Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2 (2021) (1)
- THE USE OF SPECIFIC ANTISERA TO STUDY THE DEVELOPMENTAL REGULATION OF GUANINE NUCLEOTIDE BINDING PROTEINS (1987) (1)
- Identification and analysis of two distinct isoforms of the guanine nucleotide-binding protein Go in NG108-15 cells. (1990) (1)
- Expression of the human beta 2-adrenoceptor in NCB20 cells results in agonist activation of adenylyl cyclase and agonist-mediated selective down-regulation of Gs alpha. (1995) (1)
- Novel approaches to enhance the detection of receptor constitutive activity and inverse agonists (2003) (1)
- DECONVOLUTION OF COMPLEX G PROTEIN-COUPLED RECEPTOR SIGNALING IN LIVE CELLS : TAKING ADVANTAGE OF THE RESOLVING POWER OF DYNAMIC MASS REDISTRIBUTION TECHNOLOGY (2010) (1)
- G Protein-Coupled Receptors: GPCR-G protein fusions: Use in functional dimerization analysis (2010) (1)
- Functional Complementation and the Analysis of GPCR Dimerization (2005) (1)
- Identification and quantitation of G protein alpha-subunits. (1997) (1)
- Uncovering the pharmacology of the G protein-coupled receptor GPR 40 : high apparent constitutive activity in [ 35 S ] GTP γ S binding studies reflects binding of an endogenous agonist (2006) (1)
- Pertussis Toxin-sensitive GTP-binding Proteins in Neuronal Tissues: Recent Insights into Expression and Function (1990) (1)
- The Impact of G Proteins on Constitutive GPCR Activity (2006) (1)
- Expression of G-protein β-subunit in lean and obese Zucker rats and streptozotocin-induced diabetic and normal rats (1989) (1)
- Identification and quantitation of G-protein alpha-subunits. (2004) (1)
- Quantifying membrane protein oligomerization using two-dimensional fluorescence intensity fluctuation spectrometry (2019) (1)
- Lack of N terminal palmitoylation of G protein alpha subunits reduces membrane association. (1993) (1)
- Slow transient potassium current activated by muscarinic receptors and GTP-ase deficient form of G alpha(q) in sympathetic neurones: Dualism with M-current inhibition. (1998) (1)
- Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo (2015) (1)
- Modulation of SF 1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States Graphical (2017) (1)
- Stimulation of p70S6 kinase phosphorylation by the A2A adenosine receptor in primary human endothelial cells and in CHO cells heterologously expressing the receptor (1998) (1)
- Agonist-mediated turnover of G-protein alpha-subunit palmitoyl groups. Role in membrane insertion. (1998) (1)
- Regulation of cellular Gsα levels and basal adenylyl cyclase activity by expression of the β2-adrenoceptor in neuroblastoma cell lines (1995) (1)
- The use of lipophilic anions to facilitate uptake of triphenylmethylphosphonium cation in membrane-potential studies in neuroblastoma cells (1982) (1)
- Multiple roles for the C-terminal tail of the chemokine scavenger D6. (2013) (1)
- Abstract 231: Angiotensin-(1-9) Antagonises Cardiac Remodelling in a Mouse Model of Angiotensin Ii-induced Hypertension. (2012) (1)
- High level expression of mammalian G protein alpha subunit Gq subtypes in Escherichia coli. (1995) (1)
- Analysis of Protein Palmitoylation (1996) (1)
- Diversity in the signaling and regulation of G protein-coupled receptors (1999) (1)
- Syddansk Universitet Activity of dietary fatty acids on FFA 1 and FFA 4 and characterisation of pinolenic acid as a dual FFA 1 / FFA 4 agonist with potential effect against metabolic diseases (2015) (1)
- Combinatorial expression of functionally distinct GPCR isoforms can diversify receptor signalling response (2021) (1)
- CXCR4 as a novel target in immunology: moving away from typical antagonists (2022) (1)
- 56 MicroRNAs 99b, 181a and 181b are induced during human embryonic stem cell differentiation to vascular endothelial cells and can enhance differentiation capacity upon differentiation (2011) (1)
- Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment (2013) (1)
- How the pattern of GPCR co-expression can regulate function (2006) (0)
- Mechanism of Gonadotrophin Releasing Hormone Receptor Mediated Regulation of G-Proteins in Clonal Pituitary Gonadotrophs (1996) (0)
- Cell Cycle Regulation in Rat 1 Fibroblasts Expressing a Murine Delta Opioid Gi Linked Receptor (1999) (0)
- G-protein coupled receptor 35 activation mediates human vascular smooth muscle migration (2013) (0)
- Syddansk Universitet Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA 4 (2017) (0)
- 2 Are G proteins involved in glucocorticoid-induced hypertension? (1991) (0)
- 1 Spatial Intensity Distribution Analysis Quantifies the Extent and Regulation of Homo-Dimerization of the Secretin Receptor (2017) (0)
- The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes (2022) (0)
- Gj 3 does not contribute to the inhibition of adenylate cyclase when stimulation of an x 2-adrenergic receptor causes activation of both Gj 2 and Gj 3 (0)
- Desensitisation of the nicotinic acid receptors (2007) (0)
- Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 (2017) (0)
- Molecular Basis of Dimerization of Family A G Protein-Coupled Receptors (2005) (0)
- Polymorphisms in murine histamine receptor H1 leading to differential cell surface expression influence autoimmune disease progression (2008) (0)
- Syddansk Universitet Fatty acid 16 : 4 ( n-3 ) stimulates a GPR 120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance (2017) (0)
- Design , Synthesis , and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein – Coupled Receptors s (2019) (0)
- Mechanism of Action of G q to Inhibit G (cid:1)(cid:2) Modulation of Ca V 2.2 Calcium Channels: Probed by the Use of Receptor-G (cid:3) Tandems (2003) (0)
- Rescue of V2R mutants in NDI by pharmacological chaperones (2007) (0)
- Title Inferring Signaling Pathway Topologies from MultiplePerturbation Measurements of Specific Biochemical Species (2018) (0)
- Supplementary Figures 1–5 (2012) (0)
- GPR35: from enigma to therapeutic target. (2023) (0)
- A novel mechanism for stepwise activation of a G protein-coupled receptor by a small molecule (2016) (0)
- Monitoring Receptor Dimerisation (2004) (0)
- Agonist regulation of high affinity [3H] forskolin binding as a measure of GS alpha-adenylyl cyclase interactions. (1995) (0)
- Receptor-GFP Fusion Proteins; A study of Drug Effects on Receptor Internalisation, Trafficking and Expression (1999) (0)
- Orexin receptor activation visualised by intramolecular FRET 1 (2012) (0)
- G-proteins and second messengers in mitogenesis. (1989) (0)
- Microsoft Word-23820973-file00 (2013) (0)
- beta gamma dimers derived from both G(o) and G(I) heterotrimers transduce alpha-adrenoceptor signals to inhibition of CA(2+) channels in sympathetic neurones. (1998) (0)
- P273 Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis (2021) (0)
- Regulation of cellular Gs alpha levels and basal adenylyl cyclase activity by expression of the beta 2-adrenoceptor in neuroblastoma cell lines. (1995) (0)
- G Protein-Coupled Receptors: Introduction (2010) (0)
- , free fatty acid receptor 4 ( FFA 4 / GPR 120 ) The molecular basis of ligand interaction at Signal Transduction (2014) (0)
- Alvarez-Curto, E. and Ward, R.J. and Pediani, J.D. and Milligan, G. (2010) Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time- (2010) (0)
- Activation and Desensitisation of the Thyrotropin-Releasing Hormone Receptor Visualised by Monitoring Cellular Redistribution of a β-arrestin-1-Green Fluorescent Protein Fusion Protein (1999) (0)
- Guanine-nucleotide-binding proteins expressed in rat white adipose tissue Identification of both mRNAs and proteins corresponding to Gil, G12 and Gi3 (2005) (0)
- Measurement of agonist efficacy using an a 2 A-adrenoceptor-GiiOc fusion protein (2011) (0)
- The Translation Factor eIF3a Regulates the Extracellular Signal regulated 1 Kinase (ERK) Pathway 2 (2017) (0)
- Characterisation of SC332 a novel, non-ROCK inhibitory, stem cell survival agent suitable for large scale culture (2015) (0)
- Probing the Stoichiometry and Geometry of M3 Acetylcholine Receptors at the Plasma Membrane (2013) (0)
- How Arrestins and GRKs Regulate the Function of Long Chain Fatty Acid Receptors (2022) (0)
- M3 muscarinic receptor coupling to Gaq/11 protein facilitates mu opioid receptor desensitisation, internalisation (2011) (0)
- Interaction of the beta 2-adrenoceptor with epitope-tagged Gs alpha in NG108-15 cells. (1995) (0)
- Interacting systems in splendid isolation. Ciba foundation symposium vol. 164: Interactions among cell signalling systems (1992). Edited by R. Sato, G. R. Bock and K. Widdows. John Wiley, Chichester. xi+268pp. £42.50/$75. ISBN 0‐471‐93073‐3 (1993) (0)
- Functional coupling of receptor G-protein fusions to the cloned G-protein-gated K+ channel (2001) (0)
- Expression of Two Isoforms of the Guanine Nucleotide Binding Protein,G o , IN NG108–15 Neuroglioma Cells (1991) (0)
- S.24.04 Novel approaches to enhance the detection of receptor constitutive activity and inverse agonists (2003) (0)
- Derivation to vascular endothelium from human embryonic stem cells – The role of miRNAs in endothelial commitment (2015) (0)
- Phosphorylation of the M1 muscarinic acetylcholine receptor mediates protection in neurodegenerative disease (2021) (0)
- Quaternary Structure Determination of the M3 Muscarinic Acetylcholine Receptors Based on Spectral-FRET (2012) (0)
- G-proteins: Edited by R. Iyengar and L. Birnbaumer; Academic Press; San Diego, 1990; xviii + 651 pages; $145.00 (1991) (0)
- The quaternary structure of G protein‐coupled receptors (2005) (0)
- G Protein-Coupled Receptors: Index (2010) (0)
- Go1α palmitoylation: Its contribution to α2C10 adrenoceptor - Go1α coupling (1995) (0)
- Materials and Methods Relating to G-Protein Coupled Oligomers (2011) (0)
- G(o1) alpha palmitoylation: its contribution to alpha 2C10 adrenoceptor--G(o1) alpha coupling. (1995) (0)
- The Use of Stably Transfected Cell Lines in the Analysis of Functional Interactions between Goα1 & Giα2 and the α2C10 Adrenoceptor (1995) (0)
- Contents Vol. 52, 2015 (2016) (0)
- Wnt/Frizzled receptor signaling in osteoporosis (2010) (0)
- Analysis of the relative interactions between the x2ClO adrenoceptor and the guanine-nucleotide-binding proteins Golx and G,2a following co-expression of these polypeptides in Rat 1 fibroblasts (2005) (0)
- 38 Alterations in the levels and function of guanine nucleotide regulatory proteins in Milan hypertensive rats (1993) (0)
- FUNCTIONAL INTERACTIONS OF PERTUSSIS TOXIN-SENSITIVE G-PROTEINS WITH THE TRANSFECTED μ-OPIOID RECEPTOR IN RAT 1 FIBROBLASTS (1995) (0)
- Detection and analysis of agonist-induced formation of the complex of the stimulatory guanine nucleotide-binding protein with adenylate cyclase in intact wild-type and f2-adrenoceptor-expressing NG108-15 cells (2005) (0)
- Pertussis toxin-sensitive and -insensitive mechanisms for diacylglycerol-protein kinase C signalling during insulin action in BC3H-1 myocytes. (1990) (0)
- All the right signals Signal transduction (1997) (0)
- BS7 Angiotensin-(1–9) inhibits neointima formation in a murine vein graft model and modulates ERK1/2 phosphorylation and microRNA-132 pathways in human vascular smooth muscle cells (2019) (0)
- CHAPTER 223 – Using Receptor-G-Protein Chimeras to Screen for Drugs (2003) (0)
- G-protein levels and function in human and experimental hypertension (1990) (0)
- Complexities of free fatty acid receptor pharmacology (2012) (0)
- A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization (2017) (0)
- The insulin receptor tyrosyl kinase fails to phosphorylate the guanine nucleotide regulatory proteins Ni, No and p21 (1986) (0)
- Construction and Analysis of α2A-Adrenoceptor G i /G o α-Subunit Fusion Proteins (1999) (0)
- G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor Molecular Cardiology (2005) (0)
- Induction of iPS cells from Dermal Fibroblasts by High Dose HIV-Based LV Vectors in the Absence of Reprogramming Factors: Analysis of Integration Sites and Genomic Stability (2010) (0)
- Contents (2020) (0)
- Probing Allosteric Binding Site Mapping in the Free Fatty Acid 2 receptor (2011) (0)
- U937 cell differentiation: G protein alterations and interaction with the chemotactic peptide receptor. (1991) (0)
- CXCR2 antagonist enhanced DOR agonist function via an allosteric mechanism (2007) (0)
- Signal transduction in Rat-1 fibroblasts expressing high levels of the alpha 2-C10 adrenergic receptor. (1991) (0)
- Regulation of the pro-inflammatory G protein-coupled receptor GPR84. (2023) (0)
- Defining the molecular mode of binding for α‐linolenic acid and the synthetic ligand TUG891 at GPR120 (2013) (0)
- Novel and potent GPR35 agonists aid identification of residues important in ligand interaction (2013) (0)
- Characterisation of Three Subtypes of Rat Thyrotropin Releasing Hormone Receptor (1999) (0)
- Selective interactions of the rat μ-opioid receptor and a chimeric μ-opioid receptor expressed in COS-7 cells with multiple G proteins (1997) (0)
- Internalisation of Wild type and Mutant α 1B -Adrenergic Receptors (1999) (0)
- Altered pharmacology of chemokine receptors CXCR1 and CXCR2 hetero-oligomers (2007) (0)
- A general method to quantify ligand-driven oligomerization using single- or two-photon excitation microscopy (2018) (0)
- Activation of the gonadotrophin releasing hormone receptor of alpha T3 cells results in downregulation of the alpha subunits of both Gq/G11. (1993) (0)
- Materials and methods which relate to G-protein coupled receptor oligomeric (2004) (0)
- Specificity and functional applications of antipeptide antisera which identify G-protein alpha subunits. (1994) (0)
- FFA2-elicited glucagon like peptide-1 secretion: Roles of Gαi and Gαq (2016) (0)
- 17-P003 Discovery of small molecules to control human embryonic stem cell fate (2009) (0)
- Cellular Localization and Pharmacological Characterization of Functioning Alpha-1 Adrenoceptors by Fluorescent Ligand Binding and Image Analysis Reveals Identical Binding Properties of Clustered and Diffuse Populations of Receptors 1 (1998) (0)
- A general method to quantify ligand-driven oligomerization from fluorescence-based images (2019) (0)
- The S1P1 receptor antagonist W146 induces lymphopenia in mice. Demonstration that functional antagonism of S1P1 is the mechanism of lymphopenia evoked by fingolimod-like compounds. (140.15) (2010) (0)
- Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists. (2023) (0)
- Combinatorial expression of GPCR isoforms affects signalling and drug responses (2020) (0)
- Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition (2018) (0)
- Pro-phagocytic function and structural basis of GPR84 signaling (2023) (0)
- G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis (2021) (0)
- Microsoft Word-73148042-file00.docx (2015) (0)
- Can we drug receptors for microbially-produced metabolic hormones? (2022) (0)
- A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias (2017) (0)
- Autoimmune Disease-Associated Alleles Affect Histamine Receptor H1 Protein Trafficking and Cell Surface Expression (2008) (0)
- Angiotensin-(1-9) antagonises Angiotensin II-induced cardiac remodeling via the angiotensin type 2 receptor (2012) (0)
- Contents (2020) (0)
- Functional interaction between 5HT2A serotonin receptor and 1 adrenergic receptor in mouse prefrontal cortex (2012) (0)
- ExpressionProtein Trafficking and Cell Surface Alleles Exhibit Differential 1 Receptor H Autoimmune Disease-Associated Histamine (2008) (0)
- Abstract 454: Validation of GPR35 as a novel cancer target in digestive tract cancers and discovery of potent, selective GPR35 inverse agonists (2023) (0)
- On-target and off-target effects of novel orthosteric and allosteric activators of GPR84 (2019) (0)
- A constitutively active mutant of the α1B-adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins Gqα and G11α than the wild-type receptor (1996) (0)
- Effect of muscle cell differentiation upon G-protein levels. (1990) (0)
- Immunoprecipitation of solubilized opioid receptor-Go protein complexes using specific GTP-binding protein antisera (1994) (0)
- Molecular genetic approaches. IV. Recombinant expression of wild-type and acylation-resistant G-protein alpha-subunits using transient transfection systems. (1998) (0)
- Signalling functions and G protein specificity of the mouse δ opioid receptor following expression in Rat 1 fibroblasts (1995) (0)
- Molecular Genetic Approaches IV (1998) (0)
- Identification of stable opioid receptor Go-protein complexes using GTP-binding protein selective antisera (1995) (0)
- guanine-nucleotide-binding protein (G;) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates (2005) (0)
- Incorporation of Fluorescently Tagged Chemokine Receptor 5 (CCR5) into Membrane Nanoparticles (2013) (0)
- Visualising signal initiation and termination by G protein-coupled receptors (2000) (0)
- Syddansk Universitet Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR 84 (2017) (0)
- Signalling characteristics of thyrotropin releasing hormone (TRH) receptor isoforms. (1995) (0)
- the Medulla of Neurons in Superficial and Deeper Dorsal Horn of -Adrenoceptors Modulate NMDA-Evoked Responses (2015) (0)
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What Schools Are Affiliated With Graeme Milligan?
Graeme Milligan is affiliated with the following schools:
