Graham A. R. Johnston

Graham A. R. Johnston's AcademicInfluence.com Rankings

Biology

#4798

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#7109

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Neuroscience

#520

World Rank

#540

Historical Rank

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Biology

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Graham A. R. Johnston's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Amino acid transmitters in the mammalian central nervous system. (1974) (1100)
Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat. (1971) (679)
THE ‘ABC’ OF GABA RECEPTORS: A BRIEF REVIEW (1999) (430)
Antagonism between bicuculline and GABA in the cat brain. (1971) (359)
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology. (2000) (330)
GABAA receptor pharmacology. (1996) (312)
UPTAKE AND RELEASE OF D‐ AND L‐ASPARTATE BY RAT BRAIN SLICES (1976) (312)
A new class of GABA agonist (1977) (310)
GABA(A) receptor channel pharmacology. (2005) (291)
Central nervous system depressant action of flavonoid glycosides. (2006) (270)
GABAc receptors: relatively simple transmitter -gated ion channels? (1996) (257)
Excitation of mammalian central neurones by acidic amino acids. (1972) (233)
Amino Acid Transmitters (1970) (227)
2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors (1988) (206)
Central actions of ibotenic acid and muscimol. (1968) (203)
Neuropharmacology of amino acid inhibitory transmitters. (1978) (203)
Bicuculline-insensitive GABA receptors: Studies on the binding of (−)-baclofen to rat cerebellar membranes (1984) (187)
INHIBITION OF THE UPTAKE OF GABA AND RELATED AMINO ACIDS IN RAT BRAIN SLICES BY THE OPTICAL ISOMERS OF NIPECOTIC ACID (1976) (187)
Central effects of -(p-chlorophenyl)-?-aminobutyric acid (1974) (186)
GABA agonists and antagonists. (1979) (186)
CIS‐ AND TRANS‐4‐AMINOCROTONIC ACID AS GABA ANALOGUES OF RESTRICTED CONFORMATION (1975) (179)
Convulsive action of penicillin. (1972) (171)
Flavonoid modulation of GABAA receptors (2011) (171)
(+)- And (−)-borneol: efficacious positive modulators of GABA action at human recombinant α1β2γ2L GABAA receptors (2005) (169)
Diazepam enhancement of low affinity GABA binding to rat brain membranes (1982) (159)
Glutamate uptake by brain slices and its relation to the depolarization of neurones by acidic amino acids. (1972) (154)
Betel nut constituents as inhibitors of γ-aminobutyric acid uptake (1975) (139)
The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. (2004) (137)
Bicuculline methochloride as a GABA antagonist. (1972) (134)
GABAC receptors. (1994) (125)
The hyperpolarization of spinal motoneurones by glycine and related amino acids (2004) (122)
Glutamate : transmitter in the central nervous system (1981) (117)
Effects of a naturally occurring neurosteroid on GABAA IPSCs during development in rat hippocampal or cerebellar slices (1999) (117)
Enhancement of GABA binding by benzodiazepines and related anxiolytics. (1983) (115)
Advantages of an antagonist: bicuculline and other GABA antagonists (2013) (111)
Kava pyrones and resin: studies on GABAA, GABAB and benzodiazepine binding sites in rodent brain. (1992) (110)
Bicuculline and Central GABA Receptors (1970) (108)
Medicinal chemistry and molecular pharmacology of GABA(C) receptors. (2002) (108)
A pharmacological study of the depression of spinal neurones by glycine and related amino acids (2004) (104)
Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions. (1998) (104)
The Flavonoid Glycosides, Myricitrin, Gossypin and Naringin Exert Anxiolytic Action in Mice (2009) (103)
COMPETITIVE INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY SOME GABA ANALOGUES OF RESTRICTED CONFORMATION (1972) (100)
GLUTAMATE AND RELATED AMINO ACIDS IN CAT SPINAL ROOTS, DORSAL ROOT GANGLIA AND PERIPHERAL NERVES (1970) (99)
Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. (1997) (98)
Convulsions induced in 10-day-old rats by intraperitional injection of monosodium glutamate and related excitant amino acids. (1973) (95)
Enhancement of GABA binding by pentobarbitone (1980) (93)
GABA UPTAKE IN RAT BRAIN SLICES: INHIBITION BY GABA ANALOGUES AND BY VARIOUS DRUGS (1973) (86)
Modulation of ionotropic GABA receptors by natural products of plant origin. (2006) (85)
Plasma gaba, gaba‐like activity and the brain gaba‐benzodiazepine receptor complex in rats with chronic hepatic encephalopathy (1987) (84)
GABA(C) receptors as drug targets. (2003) (82)
The Anxiogenic-Like and Anxiolytic-Like Effects of MDMA on Mice in the Elevated Plus-Maze A Comparison With Amphetamine (1999) (82)
Increased GABA binding in mouse brain following acute swim stress (1981) (82)
Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 1. Neurochemical Studies (1983) (81)
A purinergic component in the anticonvulsant action of carbamazepine? (1982) (80)
Pharmacology of barbiturates: electrophysiological and neurochemical studies. (1983) (80)
Glutamate and γ‐Aminobutyric Acid Neurotransmitter Systems in the Acute Phase of Maple Syrup Urine Disease and Citrullinemia Encephalopathies in Newborn Calves (1992) (80)
Optimization of freezing, storage, and thawing conditions for the preparation of metabolically active synaptosomes from frozen rat and human brain. (1986) (80)
Glycine, strychnine, picrotoxin and spinal inhibition. (1969) (78)
Novel, Potent, and Selective GABAC Antagonists Inhibit Myopia Development and Facilitate Learning and Memory (2008) (78)
Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids. (1990) (77)
Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks. (1995) (75)
The specificity of strychnine as a glycine antagonist in the mammalian spinal cord (1971) (74)
Brain γ-aminobutyric acid receptor binding is normal in rats with thioacetamide-induced hepatic encephalopathy despite elevated plasma γ-aminobutyric acid-like activity (1987) (73)
Regional Heterogeneity of L‐Glutamate and L‐Aspartate High‐Affinity Uptake Systems in the Rat CNS (1991) (69)
(+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors. (2005) (67)
Potency of GABA at human recombinant GABAA receptors expressed in Xenopus oocytes: a mini review (2013) (65)
Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA (2015) (65)
Stress and GABAA receptors (2010) (64)
Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant α1β2γ2L GABAA receptors (2003) (64)
Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. (2015) (64)
Deficit of spinal cord glycine/strychnine receptors in inherited myoclonus of Poll Hereford calves. (1988) (61)
Muscimol as an Ionotropic GABA Receptor Agonist (2014) (61)
Synthetic analogs for the study of GABA as a neurotransmitter (1983) (61)
Dual Action of Pentobarbitone on GABA Binding: Role of Binding Site Integrity (1981) (60)
Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant α1β2γ2L GABAA receptors (2004) (60)
Bicuculline‐ and Baclofen‐Insensitive γ‐Aminobutyric Acid Binding to Rat Cerebellar Membranes (1992) (60)
Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. (2003) (60)
GABAC receptor antagonists differentiate between human ρ1 and ρ2 receptors expressed in Xenopus oocytes (1998) (58)
GABA Receptors and Phospholipids (1978) (58)
Enhancement by anesthetic and convulsant barbiturates of GABA binding to rat brain synaptosomal membranes (1981) (56)
Natural and synthetic substances related to human health (IUPAC Technical Report) (2002) (55)
Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 2. Pharmacological Studies (1983) (54)
Glycine and spinal inhibition (1967) (54)
4-aminotetrolic acid: new conformational-restricted analogue of -aminobutyric acid. (1971) (53)
THE OXIDATION OF GLYCINE BY d‐AMINO ACID OXIDASE IN EXTRACTS OF MAMMALIAN CENTRAL NERVOUS TISSUE (1969) (52)
Neurochemical studies on quinolone antibiotics: effects on glutamate, GABA and adenosine systems in mammalian CNS. (1989) (51)
Sex Differences in Acute Swim Stress‐Induced Changes in the Binding of MK‐801 to the NMDA Subclass of Glutamate Receptors in Mouse Forebrain (1993) (51)
A Molecular Basis for Agonist and Antagonist Actions at GABAC Receptors (2008) (50)
Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin‐Q (2011) (50)
Identification of Functional Domains of the Human Glutamate Transporters EAAT1 and EAAT2* (1998) (49)
Transamination of analogues of γ-aminobutyric acid by extracts of rat brain mitochondria (1973) (49)
Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA (1989) (48)
Sex Differences in the Effects of Acute Swim Stress on Binding to GABAA Receptors in Mouse Brain (1993) (47)
(+)‐ and (‐)‐cis‐2‐Aminomethylcyclopropanecarboxylic Acids Show Opposite Pharmacology at Recombinant ρ1 and ρ2 GABAC Receptors (2000) (47)
GABAA Receptors Containing ρ1 Subunits Contribute to In Vivo Effects of Ethanol in Mice (2014) (47)
Alterations in Cortical [3H]Kainate and α‐[3H]Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Binding in a Spontaneous Canine Model of Chronic Hepatic Encephalopathy (1991) (46)
Antagonism of neuronal excitation by 1-hydroxy-3-aminopyrrolidone-2. (1973) (46)
2′‐Methoxy‐6‐methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABAA receptors (2012) (46)
Differences in uptake kinetics of cis-3-aminocyclohexane carboxylic acid into neurons and astrocytes in primary cultures (1983) (46)
Effects of calcium on the potassium-stimulated release of radioactive β-alanine and γ-aminobutyric acid from slices of rat cerebral cortex and spinal cord (1977) (45)
Flavan-3-ol derivatives are positive modulators of GABAA receptors with higher efficacy for the α2 subtype and anxiolytic action in mice (2008) (45)
SEX DIFFERENCES IN THE EFFECTS OF GONADECTOMY AND ACUTE SWIM STRESS ON GABAA RECEPTOR BINDING IN MOUSE FOREBRAIN MEMBRANES (1997) (45)
Flumazenil-independent positive modulation of γ-aminobutyric acid action by 6-methylflavone at human recombinant α1β2γ2L and α1β2 GABAA receptors (2004) (45)
GABA Receptor Pharmacology (1995) (43)
Inhibition of spinal neurons by glycine. (1967) (43)
Pyrazolo[3,4-d]pyrimidines as adenosine antagonists. (1984) (43)
Postnatal development of GABA binding sites and their endogenous inhibitors in rat brain. (1982) (43)
Comparison of binding parameters of σ1 and σ2 binding sites in rat and guinea pig brain membranes: novel subtype-selective trishomocubanes (1996) (42)
Pyrazolo [3,4-d] pyrimidines, a new class of adenosine antagonists (1983) (42)
Glutamate and Huntington's Disease (1981) (42)
TETANUS TOXIN AND AMINO ACID LEVELS IN CAT SPINAL CORD (1969) (39)
Natural and synthetic substances related to human health (2002) (39)
6-Methylflavanone, a more efficacious positive allosteric modulator of γ-aminobutyric acid (GABA) action at human recombinant α2β2γ2L than at α1β2γ2L and α1β2 GABAA receptors expressed in Xenopus oocytes (2005) (39)
3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes. (2011) (39)
Stereoselective interaction of thiopentone enantiomers with the GABAA receptor (1999) (38)
Unsaturated phosphinic analogues of γ-aminobutyric acid as GABAC receptor antagonists (1997) (38)
Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors. (2012) (37)
Flavonoids: some of the wisdom of sage? (2004) (37)
Purines interact with ‘central’ but not ‘peripheral’ benzodiazepine binding sites (1982) (36)
Idiospermuline, a trimeric pyrrolidinoindoline alkaloid from the seed of Idiospermum australiense. (1995) (36)
A new synthesis, resolution and in vitro activities of (R)- and (S)-β-phenyl-GABA (1990) (36)
Cortisol: A potent biphasic modulator at GABAA-receptor complexes in the guinea pig isolated ileum (1987) (36)
Glycine:2-oxoglutarate transaminase in rat cerebral cortex. (1969) (34)
(+)‐Hydrastine, a potent competitive antagonist at mammalian GABAA receptors (1990) (33)
GABA Transporters GAT-1 and GAT-3 in the Human Dorsolateral Prefrontal Cortex in Schizophrenia (2004) (33)
Novel oral drug administration in an animal model of neuroleptic therapy (2005) (33)
Serine‐O‐sulphate transport by the human glutamate transporter, EAAT2 (1998) (33)
trans‐4‐Amino‐2‐methylbut‐2‐enoic acid (2‐MeTACA) and (±)‐trans‐2‐aminomethylcyclopropanecarboxylic acid ((±)‐TAMP) can differentiate rat ρ3 from human ρ1 and ρ2 recombinant GABAC receptors (2002) (32)
Uptake of γ-aminobutyric acid andl-glutamic acid by synaptosomes from postmortem human cerebral cortex: multiple sites, sodium dependence and effect of tissue preparation (1989) (32)
Interactions of flavonoids with ionotropic GABA receptors. (2015) (32)
GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators. (2019) (32)
Effect of GABA-Fortified Oolong Tea on Reducing Stress in a University Student Cohort (2019) (32)
Analogues of γ‐aminobutyric acid (GABA) and trans‐4‐aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists (1997) (32)
Glutamate and related amino-acids in cat, dog, and rat spinal roots. (1970) (31)
Chapter 8 GABAc receptors (1994) (31)
Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. (2008) (31)
d‐ASPARTATE OXIDASE ACTIVITY IN EXTRACTS OF MAMMALIAN CENTRAL NERVOUS TISSUE (1975) (31)
Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy (1996) (30)
Isothiouronium compounds as γ‐aminobutyric acid agonists (1986) (30)
Differences in the interactions between GABA and benzodiazepine binding sites (1982) (30)
Glutamate and imprinting memory: the role of glutamate receptors in the encoding of imprinting memory (1993) (29)
Medicinal chemistry of ρ GABAC receptors. (2011) (29)
Neurochemicals for the Investigation of GABAC Receptors (2010) (29)
GABAB-receptor-mediated actions of baclofen in rat isolated neocortical slice preparations: antagonism by phosphono-analogues of GABA (1989) (29)
Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake. (1975) (29)
The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined (2007) (29)
GABA‐ρ receptors: distinctive functions and molecular pharmacology (2017) (29)
INHIBITION OF AMINO ACID TRANSMITTER RELEASE FROM RAT BRAIN SLICES BY PHENYTOIN AND RELATED ANTICONVULSANTS (1983) (29)
Liberation of amino acids during the preparation of brain slices (1975) (28)
3-aminopropanephosphinic acid is a potent agonist at peripheral and central presynaptic GABAB receptors (1990) (28)
Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors. (2003) (28)
Inhibition of acetylcholinesterase by bicuculline and related alkaloids (1975) (27)
Uptake of gamma-aminobutyric acid by human blood platelets: comparison with CNS uptake. (1985) (27)
An improved, versatile synthesis of the GABAC antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA) (2001) (26)
The effects of anaesthetic and convulsant barbiturates on the efflux of [3H]d-aspartate from brain minislices (1980) (26)
Serine hydroxymethyltransferase in the central nervous system: regional and subcellular distribution studies (1973) (26)
Charged Residues at the 2′ Position of Human GABAC ρ1 Receptors Invert Ion Selectivity and Influence Open State Probability* (2004) (26)
Novel Cyclic Phosphinic Acids as GABAC ρ Receptor Antagonists: Design, Synthesis, and Pharmacology. (2011) (26)
Molecular Biology, Pharmacology, and Physiology of GABAC Receptors (1997) (26)
Benzofuran analogues of baclofen: a new class of central and peripheral GABAB-receptor antagonists. (1989) (25)
Guanidino Acids Act as ρ1 GABAC Receptor Antagonists (2009) (25)
Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. (2011) (25)
GABA and barbiturate receptors (1982) (25)
Modulation of GABA binding to rat brain membranes by alkyl beta-carboline-3-carboxylate esters. (1982) (25)
GABA RECEPTORS: AS COMPLEX AS ABC? (1994) (25)
Necropsy study of GABA/benzodiazepine receptor binding sites in brain tissue from chronic alcoholic patients. (1988) (25)
Pentobarbitone slows the dissociation of GABA from rat brain synaptosomal binding sites (1981) (25)
Contrasting regulation by GABA of the displacement of benzodiazepine antagonist binding by benzodiazepine agonists and purines (1982) (24)
Conformational analysis of muscimol, a GABA agonist. (1979) (24)
Inhibition of high affinity l-glutamic acid uptake into rat cortical synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic acid (1991) (24)
Synthesis of Analogues of GABA. XIV. Synthesis and Activity of Unsaturated Derivatives of 5-Aminopentanoic Acid (d-Aminovaleric Acid) (1985) (24)
Barbiturates and GABA receptors. (1981) (24)
Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site (2011) (24)
R-(-)-beta-phenyl-GABA is a full agonist at GABAB receptors in brain slices but a partial agonist in the ileum. (1993) (23)
Strychnine, Glycine and Vertebrate Postsynaptic Inhibition (1970) (23)
Regional and subcellular distribution studies on glycine:2-oxoglutarate transaminase activity in cat spinal cord. (1970) (23)
Flavan‐3‐ol esters: new agents for exploring modulatory sites on GABAA receptors (2012) (23)
Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone (2014) (23)
Herbal Products and GABA Receptors (2009) (23)
Routine screening and quantitation of urinary corticosteroids using bench-top gas chromatography-mass-selective detection. (1992) (23)
The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABA(C) receptors. (2001) (23)
GABAA Receptor Modulation by Compounds Isolated from Salvia triloba L. (2014) (22)
Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. (2004) (22)
Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. (2006) (22)
Glycine-producing transaminase activity in extracts of spinal cord. (1969) (22)
Cortical dihydrophyridine binding sites are unaltered in human alcoholic brain (1989) (22)
Aza-THIP and related analogues of THIP as GABA C antagonists. (2003) (22)
Regional differences in the inhibition of l-glutamate and l-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by l-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-d-aspartate and d-aspartate (1994) (22)
Diazepam stimulates the binding of GABA and muscimol but not thip to rat brain membranes (1983) (22)
Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen, 3-aminopropylphosphonic acid and related GABAB receptor antagonists (1990) (21)
Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. (2009) (21)
Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. (2008) (21)
ADENOSINE RECEPTORS IN POST‐MORTEM HUMAN CEREBRAL CORTEX AND THE EFFECT OF CARBAMAZEPINE (1986) (21)
Resolution of the stereoisomers of baclofen by high performance liquid chromatography (1984) (21)
γ‐Aminobutyric Acid Receptor Ionophore Complexes: Differential Effects of Deltamethrin, Dichlorodiphenyltrichloroethane, and Some Novel Insecticides in a Rat Brain Membrane Preparation (1987) (21)
A single amino acid determines the toxicity of Ginkgo biloba extracts (2012) (20)
Differing actions of baclofen and 3-amino-propylphosphinic acid in rat neocortical slices (1990) (20)
Allylglycine, an inhibitor of the uptake of l-leucine and l-proline in rat brain slices (1974) (20)
GABAB antagonists: resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen. (1994) (20)
Ionotropic GABA Receptors as Therapeutic Targets for Memory and Sleep Disorders (2004) (19)
Identification of Benzopyran‐4‐one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors (2011) (19)
Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAC receptor antagonists (2003) (19)
Differing actions of β-phenyl-GABA and baclofen in the guinea pig isolated ileum (1987) (19)
Interactions of carbamazepine with benzodiazepine receptors (1983) (18)
Mutations of the 2′ proline in the M2 domain of the human GABAC ρ1 subunit alter agonist responses (2004) (18)
Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists of ρ1 GABAC Receptors. (2013) (18)
Profiling of urinary testosterone and luteinizing hormone in exercise-stressed male athletes, using gas chromatography-mass spectrometry and enzyme immunoassay techniques. (1996) (18)
Central actions of shikimin and tutin. (1973) (17)
(3-Aminocyclopentyl)methylphosphinic acids: Novel GABAC receptor antagonists (2007) (17)
Resolution and conformational analysis of diastereoisomeric esters of cis- and trans-2-(aminomethyl)-1-carboxycyclopropanes (1998) (17)
Increased γ‐Aminobutyric Acid Receptor Function in the Cerebral Cortex of Myoclonic Calves with an Hereditary Deficit in Glycine/Strychnine Receptors (1990) (17)
Acute effects of lead at central synapses in vitro (1985) (17)
Reduced adenosine deaminase activity in the CNS of spontaneously-hypertensive rats (1987) (17)
Neuropharmacology: Propylene Glycol Elicits Anxiolytic‐like Responses to the Elevated Plus‐maze in Male Mice (1998) (17)
Contrasting effects of a convulsant (CHEB) and an anticonvulsant barbiturate (phenobarbitone) on amino acid release from rat brain slices (1983) (17)
Pregnenolone and its sulphate modulate GABAA-receptor-mediated contractile responses in the guinea-pig isolated ileum. (1987) (17)
Comparison of binding parameters of sigma 1 and sigma 2 binding sites in rat and guinea pig brain membranes: novel subtype-selective trishomocubanes. (1996) (16)
Phenobarbitone binding sites in rat brain synaptosomal membranes (1981) (16)
X-Ray Crystallographic and Proton Magnetic Resonance Spectroscopic Investigations of Nipecotic Acid, a Potent Inhibitor of gamma-Aminobutyric Acid (GABA) Uptake. (1976) (16)
The inactivation of extracellularly administered amino acids in the feline spinal cord (1970) (16)
Bicuculline and GABA-metabolising enzymes. (1972) (16)
Cortisone: a potent GABAA antagonist in the guinea‐pig isolated ileum (1990) (16)
Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531). (2010) (15)
GABAa AGONISTS AS TARGETS FOR DRUG DEVELOPMENT (1992) (15)
Convulsant actions of calycanthine. (2003) (15)
Long‐lasting effects of early‐life intervention in mice on adulthood behaviour, GABAA receptor subunit expression and synaptic clustering (2017) (14)
Glutamate and aspartate as transmitters in the spinal cord. (1976) (14)
Effects of bilobalide, ginkgolide B and picrotoxinin on GABAA receptor modulation by structurally diverse positive modulators (2017) (14)
GABA(C) receptor antagonists differentiate between human rho1 and rho2 receptors expressed in Xenopus oocytes. (1998) (14)
GABAA receptor cysteinyl mutants and the ginkgo terpenoid lactones bilobalide and ginkgolides. (2016) (13)
Synaptosomal and brain slice cerebrocortical [3H]l-glutamate uptake in a rat model of chronic hepatic encephalopathy (1996) (13)
Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. (2006) (13)
Synthesis of analogues of γ-aminobutyric acid. Part 11. Unsaturated and saturated tetronic acid [furan-2,4(3H,5H)-dione] derivatives (1983) (13)
Muscimol and the uptake of γ-aminobutyric acid by rat brain slices (2004) (13)
Calcium dependence of baclofen- and GABA-induced depression of responses to transmural stimulation in the guinea-pig isolated ileum. (1987) (12)
Neurotoxic Amino Acids (1974) (12)
Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ρ1 receptor. (2012) (12)
Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABAA receptor binding sites (2008) (12)
( + )-And ( )-borneol : efficacious positive modulators of GABA action at human recombinant a 1 b 2 g 2 L GABAA receptors (2005) (12)
Alfaxalone potentiates and mimics GABA‐induced contractile responses in the guinea‐pig isolated ileum (1988) (12)
Ethylenediamine as a GABA agonist: Enhancement of diazepam binding and interaction with GABA receptors and uptake sites (1982) (12)
High affinity uptake of cyclic AMP in rat brain slices. (1973) (12)
Stimulation of [3H]GABA and β‐[3H]Alanine Release from Rat Brain Slices by cis‐4‐Aminocrotonic Acid (1997) (11)
Γ-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates. (2013) (11)
GABA-enriched teas as neuro-nutraceuticals (2020) (11)
Differentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ρ(1) receptors. (2012) (11)
High affinity uptake of cAMP in rat brain: Inhibition by coronary vasodilators dilazep and hexobendine (1988) (11)
Plasma gaba‐like activity in rats with hepatic encephalopathy is due to gaba and taurine (1990) (11)
Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors (2012) (11)
The preparation of tritiated E- and Z-4-aminobut-2-enoic acids, conformationally restricted analogues of the inhibitory neurotransmitter 4-aminobutanoic acid (GABA) (1993) (11)
Synthesis and resolution of 2-methyl analogues of GABA (2004) (11)
GABA, The Major Inhibitory Neurotransmitter in the Brain (2018) (11)
Effect of ethanol on the GABA-benzodiazepine receptor in brain. (1987) (10)
Central effects of beta-(para-chlorophenyl)-gamma-aminobutyric acid. (1974) (10)
ZAPA, a substrate for the neuronal high affinity GABA uptake system in rat brain slices (1991) (10)
Structural analogues of ZAPA as GABAA agonists (1997) (10)
Enhancement of excitant amino acid release from rat brain slices by the convulsant 3-mercaptopropionic acid (1983) (10)
Effects of Lead Salts on the Uptake, Release, and Binding of γ‐Aminobutyric Acid: The Importance of Buffer Composition (1989) (10)
Gamma-aminobutyric acid-modulated benzodiazepine binding sites in bacteria. (1991) (9)
Tautomerism of hydroxy-pyridazines: the N-oxides (1997) (9)
Unsaturated phosphinic analogues of gamma-aminobutyric acid as GABA(C) receptor antagonists. (1997) (9)
Receptor alterations associated with spinal motoneuron degeneration in Bovine Akabane disease (1990) (9)
Novel γ-Aminobutyric Acid G1 Receptor Antagonists; Synthesis, Pharmacological Activity and Structure-Activity Relationships (2008) (9)
Synthesis of analogues of GABA. IX. 5-(Aminomethyl)-3-hydroxyfuran-2(5H)-one (1983) (9)
(+)- and (-)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors. (2000) (9)
Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. (2004) (9)
Chiral derivatives of 2-cyclohexylideneperhydro-4,7-methanoindenes, a novel class of nonsteroidal androgen receptor ligand: synthesis, X-ray analysis, and biological activity. (2000) (9)
Barbiturates and calcium-activated adenosine triphosphatase (1979) (9)
Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity. (2008) (8)
Theoretical studies on the free-radical bromination of methyl-pyridazines in the synthesis of novel (1996) (8)
Cyclobutane analogs of GABA (1980) (8)
Interaction of purines and related compounds with photoaffinity-labelled benzodiazepine receptors in rat brain membranes. (1984) (8)
93. Constituents of the bark of Balanops australiana F. Muell (1962) (8)
6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. (2005) (8)
Molecular orbital and proton magnetic resonance studies of bicuculline. (1973) (8)
Mixed antagonistic effects of bilobalide at ρ1 GABAC receptor (2006) (8)
Vintage amino acid meeting describes new tools for amino acid research, subtypes of metabotropic receptors. (1991) (7)
Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids (2016) (7)
Synthesis of Unsaturated Analogues of Glutamic Acid: Amination of Trianions From Unsaturated Dicarboxylic Acids With Chloramine (1996) (7)
Ontogeny of high affinity uptake of GABA studied in 'minislices' (tissue prisms) of rat cerebral cortex. (1989) (7)
γ‐Aminobutyrylcholine and central inhibition (1972) (7)
Metabolomic Approaches to Defining the Role(s) of GABAρ Receptors in the Brain (2015) (7)
L-glutamate and γ-aminobutyric acid uptake in synaptosomes from the cerebral cortex of dogs with congenital chronic hepatic encephalopathy (1995) (7)
Brain gamma-aminobutyric acid receptor binding is normal in rats with thioacetamide-induced hepatic encephalopathy despite elevated plasma gamma-aminobutyric acid-like activity. (1987) (7)
Low nanomolar GABA effects at extrasynaptic a 4 b 1 / b 3 d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors (2012) (7)
Stereospecific Actions of GABA Analogues (1979) (7)
Medicinal chemistry and molecular pharmacology of GABA receptors and glutamate transporters—Complementary structure–activity relationships (1999) (6)
Brain gaba receptor binding and plasma gaba-like activity in a model of chronic hepatic encephalopathy in rats (1986) (6)
Flavonoid Actions on Receptors for the Inhibitory Neurotransmitter GABA (2017) (6)
Uptake of gamma-aminobutyric acid and glycine by synaptosomes from postmortem human brain. (1986) (6)
Differential modulation of γ-aminobutyric acid receptors by caprolactam derivatives with central nervous system depressant on convulsant activity (1985) (6)
Sex differences in acute swim stress induced changes in the binding of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and kainate to glutamate receptors in mouse forebrain (1994) (6)
Polyclonal Antibodies to the Glycine Receptor Antagonist Strychnine (1989) (6)
Bicuculline- and baclofen-insensitive gamma-aminobutyric acid binding to rat cerebellar membranes. (1992) (6)
Biochemistry of Glycine, Taurine, Glutamate, and Aspartate (1975) (6)
Glycine Enzymes and Uptake Systems (1975) (6)
Synapic depression and adenosine (1988) (5)
Interactions of some anaesthetic, convulsant, and anticonvulsant drugs at GABA-benzodiazepine receptor-ionophore complexes in rat brain synaptosomal membranes (1983) (5)
640. Steroids and Walden inversion. Part XLVIII. The solvolysis of some 3-epimeric 4,4-dimethyl-steroid toluene-p-sulphonates (1961) (5)
The synthesis of 2-cyclohexylideneperhydro-4,7-methanoindenes. Non-steroidal analogues of steroidal GABAA receptor modulators (1998) (5)
Depolarizing actions of convulsant barbiturates on isolated rat dorsal root ganglion cells (1988) (5)
6-Methylflavone (2001) (4)
GABA Analogues Derived from 4-Aminocyclopent-1-enecarboxylic Acid (2009) (4)
Rand Lecture, ASCEPT. GABA receptors: as complex as ABC? Australaisian Society for Clinical and Experimental Pharmacologists and Toxicologists. (1994) (4)
GABA Australis, some reflections on the history of GABA receptor research in Australia (2017) (4)
Cerebellar [3H]kainate and [3H]ampa binding in dogs with congenital portosystemic encephalopathy (1991) (4)
Sex-differences and stress : Effects on regional high and low affinity [ 3 H ] GABA binding (2008) (4)
Direct excitant action of convulsant barbiturates (1981) (4)
Purine enzyme inhibition fails to alter benzodiazepine receptor binding in brain (1988) (4)
Increase in Plasma Gaba-Like Factor That Is Not Gaba Itself in Acute and Chronic Models of Hepatic-Encephalopathy in Rats (1986) (3)
Cover Picture: Identification of Benzopyran‐4‐one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors (ChemMedChem 8/2011) (2011) (3)
Effect of chronic exposure to lead on GABA binding in developing rat brain (1990) (3)
The synthesis of 1,8-disubstituted 10,11-dihydrodibenz[b,f]oxepin-10-ones. analogues of anaesthetic steroids (1991) (3)
Strychnine-like action of the convulsant barbiturate, CHEB (1985) (3)
Effects of calcium on the potassium-stimulated release of radioactive beta-alanine and gamma-aminobutyric acid from slices of rat cerebral cortex and spinal cord. (1977) (3)
Aminomethyl-2,6-difluorophenols as a novel class of increased lipophilicity GABA(C) receptor antagonists. (1999) (3)
Targeting GABAC Receptors Improves Post-Stroke Motor Recovery (2021) (3)
239. Steroids and Walden inversion. Part L. Comparative studies of α-bromo- and αα′-dibromo-ketones derived from friedelin and from 5α-cholestan-6-one (1962) (3)
Isothiouronium compounds as gamma-aminobutyric acid agonists. (1986) (3)
A New Synthesis, Resolution and in vitro Activities of (R)- and (S)-β-Phenyl-GABA. (1990) (3)
CNQX binding to non-NMDA glutamate receptors in canine cerebro-cortical crude synaptosomal membranes: Pharmacological characterization and comparison of binding parameters in dogs with congenital portosystemic encephalopathy and control dogs (1992) (3)
Effects of a depressant/convulsant pair of glutarimides on neuronal activity in the isolated spinal cord of the immature rat (1985) (3)
Actions of pentobarbitone and derivatives with modified 5-butyl substituents on GABA and diazepam binding to rat brain synaptosomal membranes (1983) (3)
Configuration of bicuculline, a GABA antagonist. (1973) (2)
Antagonists of Ionotropic Receptors for the Inhibitory Neurotransmitter GABA: Therapeutic Indications (2018) (2)
GABA-Activated Ligand Gated Ion Channels: Medicinal Chemistry and Molecular Biology (2000) (2)
Calcium-dependent actions of the convulsant barbiturate, CHEB, on transmitter release at the rat neuromuscular junction. (1990) (2)
Microwave‐Enhanced Synthesis of 2,3,6‐Trisubstituted Pyridazines: Application to Four‐Step Synthesis of Gabazine (SR‐95531). (2011) (2)
Brain extracts containing a Huntington disease antigen inhibit [3H]kainate binding and block synaptosomal amino acid transport (1993) (2)
Synthesis of ?-Aminobutyric Acid Analogues (2010) (2)
GABA receptors and related binding sites (1984) (2)
Synthesis of analogues of γ-aminobutyric acid. XI: Unsaturated and saturated tetronic acid [furan-2,4(3H,5H)-dione] (1984) (2)
[Inhibitory effect of glycine and similar amino acids on spinal neurons]. (1968) (2)
The synthesis and resolution of tritiated 4‐amino‐3‐phenylbutanoic acid ([3H]R‐ and [3H]S‐β‐phenylgaba) (1993) (2)
Aldehydic and Ketonic Monocarboxylic Acids and Related Compounds (1964) (2)
704. Steroids. Part XVI. The bromination of some 3-ketosteroids methylated in ring-A (1962) (2)
Insecticide action on GABAergic Cl flux in insect central nervous system (1988) (2)
SYNTHESIS OF ANALOGS OF GABA. III. ALL FOUR STEREOISOMERS OF 3-AMINOCYCLOPENTANECARBOXYLIC ACID AND A STEREOCHEMICAL CORRELATION WITH AMIDINOMYCIN (1980) (1)
The origins and early history of neurochemistry and its societies (2020) (1)
Synthesis of Analogues of GABA. Part 13. An Alternative Route to (Z)‐4‐Aminocrotonic Acid. (1986) (1)
516. Steroids and Walden inversion. Part LI. The solvolysis of 4,4-dimethylcholest-5-en-3α-yl toluene-p-sulphonate (1962) (1)
Gabarins and the nexus between gamma amino butyric acid and benzodiazepine receptors (1984) (1)
Glutamatergic neurotransmission in hepatic encephalopathy. (1993) (1)
SYNTHESIS OF ANALOGS OF GABA. VI. STEREOISOMERS OF CIS-3-AMINOCYCLOHEXANECARBOXYLIC ACID (1982) (1)
Protective effect of adenosine against hypoxic damage. Synaptic depression and adenosine. (1988) (1)
Aminomethyl-2,6-difluorophenols as a Novel Class of Increased Lipophilicity GABAc Receptor Antagonists. (2000) (1)
GLUTAMATE AND OTHER EXCITATORY AMINO ACIDS IN THE MAMMALIAN CNS (1976) (1)
Metabolomic Approaches to Defining the Role(s) of GABAρ Receptors in the Brain (2015) (1)
Effect of chronic lead treatment on the development of neuromuscular connections in the rat. (1987) (1)
Transamination of analogues of gamma-aminobutyric acid by extracts of rat brain mitochondria. (1973) (1)
Plasma GABA-like Factor in Hepatic Encephalopathy May Be Taurine. (1989) (1)
Aliphatic Monohydroxy-monocarboxylic Acids and Related Compounds (1964) (1)
Inhibitors of the glial uptake of beta-alanine in rat brain slices. (1976) (0)
GABA receptors. (1981) (0)
Chiral Derivatives of 2‐Cyclohexylideneperhydro‐4,7‐methanoindenes, a Novel Class of Nonsteroidal Androgen Receptor Ligand: Synthesis, X‐Ray Analysis, and Biological Activity. (2001) (0)
Further promiscuity of phenylalkylamine Ca antagonists (1988) (0)
Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids (2015) (0)
Allylglycine, and inhibitor of the uptake of L-leucine and L-proline in rat brain slices. (1974) (0)
The 33 rd Liversidge Lecture for the Royal Society of NSW Dietary Chemicals and Brain Function (0)
DIFFERENTIAL SENSITIVITY DURING DEVELOPMENT OF GABA-MEDIATED SYNAPTIC TRANSMISSION TO A NEUROACTIVE STEROID IN RAT HIPPOCAMPUS AND CEREBELLUM (1996) (0)
The Synthesis of 1,8‐Disubstituted 10,11‐Dihydrodibenz(b,f)oxepin‐10‐ ones. Analogues of Anaesthetic Steroids. (1992) (0)
Some personal thoughts on the Australasian Society of Clinical and Experimental Pharmacologists in the 1980s. (2017) (0)
S-71-5 Modulation of GABA receptors by endogenous steroids (1996) (0)
GABA agonists (1984) (0)
The Synthesis of 2-Cyclohexylideneperhydro-4,7-methanoindenes. Non-Steroidal Analogues of Steroidal GABAA Receptor Modulators. (1999) (0)
Synthesis of Analogues of GABA. Part 14. Synthesis and Activity of Unsaturated Derivatives of 5‐Aminopentanoic Acid (δ‐Aminovaleric Acid). (1986) (0)
Muscimol as an Ionotropic GABA Receptor Agonist (2014) (0)
Poster Session: Ion channels (2004) (0)
Optimising the transient expression of GABA(A) receptors in adherent HEK293 cells. (2019) (0)
The interaction of a huntington disease factor with receptors for the neurotoxin kainic acid (1991) (0)
A New Class of GABA Agonist. (1977) (0)
Charge density studies as a tool in drug design (2002) (0)
Neurotoxicity of kainate and the inactivation of L-glutamate in vivo [proceedings]. (1980) (0)
Benzodiazepines, Flavonoids, and GABA (2021) (0)
SYNTHESIS OF ANALOGS OF GABA. IX. 5-(AMINOMETHYL)-3-HYDROXYFURAN-2(5H)-ONE (1983) (0)
P-570 ANTAGONISM OF GINKGO TERPENE TRILACTONES AT GABA RECEPTORS (2006) (0)
Resolution and Conformational Analysis of Diastereoisomeric Esters of cis- and trans-2-(Aminomethyl)-1-carboxycyclopropanes. (2010) (0)
2476 – STEREOSPECIFIC ACTIONS OF GABA ANALOGUES (1978) (0)
Potency of GABA at human recombinant GABAA receptors expressed in Xenopus oocytes: a mini review (2013) (0)
An Improved, Versatile Synthesis of the GABAC Antagonists (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic Acid (TPMPA) (IX) and (Piperidin-4-yl)methylphosphinic Acid (P4MPA) (XI). (2002) (0)
Effect of exercise combined with environmental humidity on the stress response profiles of urinary cortisol, cortisone, tetrahydrocortisol and tetrahydrocortisone (1994) (0)
Non‐dopaminergic actions of quinpirole hydrochloride (LY 171555), a selective D2‐agonist, in the guinea‐pig isolated ileum (1988) (0)
In vivo effects of GABA uptake inhibitors on the response of cat spinal neurones to GABA analogues [proceedings]. (1977) (0)
Transporters (2004) (0)
The Crystal Structures of 3-Hydroxybiuret and 3-Hydroxybiuret Hemihydrate. (1976) (0)
Synthesis and Activity of a Potent N‐Methyl‐D‐aspartic Acid Agonist, trans‐1‐Aminocyclobutane‐1,3‐dicarboxylic Acid, and Related Phosphonic and Carboxylic Acids. (2010) (0)
SYNTHESIS OF ANALOGS OF GABA. V. THE TRANS AND CIS ISOMERS OF SOME 4-AMINO-3-HALOBUT-2-ENOIC ACIDS (1980) (0)
Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone (2013) (0)
A textbook of drug design and development: edited by Povl Krogsgaard-Larsen and Hans Bundgaard, Harwood Academic Publishers, 1991. $170.00/ £90.00 hbk, $48.00/£24.00 pbk (v + 643 pages) ISBN 3 7186 5099 1 hbk, 3 7186 5100 9 pbk (1992) (0)
In vitro and in vivo effects of pentobarbitone sodium (1982) (0)

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