Graham A. R. Johnston
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Graham A. R. Johnstonbiology Degrees
Biology
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Neuroscience
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#540
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Biology
Why Is Graham A. R. Johnston Influential?
(Suggest an Edit or Addition)Graham A. R. Johnston's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Amino acid transmitters in the mammalian central nervous system. (1974) (1100)
- Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat. (1971) (679)
- THE ‘ABC’ OF GABA RECEPTORS: A BRIEF REVIEW (1999) (430)
- Antagonism between bicuculline and GABA in the cat brain. (1971) (359)
- GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology. (2000) (330)
- GABAA receptor pharmacology. (1996) (312)
- UPTAKE AND RELEASE OF D‐ AND L‐ASPARTATE BY RAT BRAIN SLICES (1976) (312)
- A new class of GABA agonist (1977) (310)
- GABA(A) receptor channel pharmacology. (2005) (291)
- Central nervous system depressant action of flavonoid glycosides. (2006) (270)
- GABAc receptors: relatively simple transmitter -gated ion channels? (1996) (257)
- Excitation of mammalian central neurones by acidic amino acids. (1972) (233)
- Amino Acid Transmitters (1970) (227)
- 2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors (1988) (206)
- Central actions of ibotenic acid and muscimol. (1968) (203)
- Neuropharmacology of amino acid inhibitory transmitters. (1978) (203)
- Bicuculline-insensitive GABA receptors: Studies on the binding of (−)-baclofen to rat cerebellar membranes (1984) (187)
- INHIBITION OF THE UPTAKE OF GABA AND RELATED AMINO ACIDS IN RAT BRAIN SLICES BY THE OPTICAL ISOMERS OF NIPECOTIC ACID (1976) (187)
- Central effects of -(p-chlorophenyl)-?-aminobutyric acid (1974) (186)
- GABA agonists and antagonists. (1979) (186)
- CIS‐ AND TRANS‐4‐AMINOCROTONIC ACID AS GABA ANALOGUES OF RESTRICTED CONFORMATION (1975) (179)
- Convulsive action of penicillin. (1972) (171)
- Flavonoid modulation of GABAA receptors (2011) (171)
- (+)- And (−)-borneol: efficacious positive modulators of GABA action at human recombinant α1β2γ2L GABAA receptors (2005) (169)
- Diazepam enhancement of low affinity GABA binding to rat brain membranes (1982) (159)
- Glutamate uptake by brain slices and its relation to the depolarization of neurones by acidic amino acids. (1972) (154)
- Betel nut constituents as inhibitors of γ-aminobutyric acid uptake (1975) (139)
- The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. (2004) (137)
- Bicuculline methochloride as a GABA antagonist. (1972) (134)
- GABAC receptors. (1994) (125)
- The hyperpolarization of spinal motoneurones by glycine and related amino acids (2004) (122)
- Glutamate : transmitter in the central nervous system (1981) (117)
- Effects of a naturally occurring neurosteroid on GABAA IPSCs during development in rat hippocampal or cerebellar slices (1999) (117)
- Enhancement of GABA binding by benzodiazepines and related anxiolytics. (1983) (115)
- Advantages of an antagonist: bicuculline and other GABA antagonists (2013) (111)
- Kava pyrones and resin: studies on GABAA, GABAB and benzodiazepine binding sites in rodent brain. (1992) (110)
- Bicuculline and Central GABA Receptors (1970) (108)
- Medicinal chemistry and molecular pharmacology of GABA(C) receptors. (2002) (108)
- A pharmacological study of the depression of spinal neurones by glycine and related amino acids (2004) (104)
- Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions. (1998) (104)
- The Flavonoid Glycosides, Myricitrin, Gossypin and Naringin Exert Anxiolytic Action in Mice (2009) (103)
- COMPETITIVE INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY SOME GABA ANALOGUES OF RESTRICTED CONFORMATION (1972) (100)
- GLUTAMATE AND RELATED AMINO ACIDS IN CAT SPINAL ROOTS, DORSAL ROOT GANGLIA AND PERIPHERAL NERVES (1970) (99)
- Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. (1997) (98)
- Convulsions induced in 10-day-old rats by intraperitional injection of monosodium glutamate and related excitant amino acids. (1973) (95)
- Enhancement of GABA binding by pentobarbitone (1980) (93)
- GABA UPTAKE IN RAT BRAIN SLICES: INHIBITION BY GABA ANALOGUES AND BY VARIOUS DRUGS (1973) (86)
- Modulation of ionotropic GABA receptors by natural products of plant origin. (2006) (85)
- Plasma gaba, gaba‐like activity and the brain gaba‐benzodiazepine receptor complex in rats with chronic hepatic encephalopathy (1987) (84)
- GABA(C) receptors as drug targets. (2003) (82)
- The Anxiogenic-Like and Anxiolytic-Like Effects of MDMA on Mice in the Elevated Plus-Maze A Comparison With Amphetamine (1999) (82)
- Increased GABA binding in mouse brain following acute swim stress (1981) (82)
- Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 1. Neurochemical Studies (1983) (81)
- A purinergic component in the anticonvulsant action of carbamazepine? (1982) (80)
- Pharmacology of barbiturates: electrophysiological and neurochemical studies. (1983) (80)
- Glutamate and γ‐Aminobutyric Acid Neurotransmitter Systems in the Acute Phase of Maple Syrup Urine Disease and Citrullinemia Encephalopathies in Newborn Calves (1992) (80)
- Optimization of freezing, storage, and thawing conditions for the preparation of metabolically active synaptosomes from frozen rat and human brain. (1986) (80)
- Glycine, strychnine, picrotoxin and spinal inhibition. (1969) (78)
- Novel, Potent, and Selective GABAC Antagonists Inhibit Myopia Development and Facilitate Learning and Memory (2008) (78)
- Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids. (1990) (77)
- Prediction of receptor properties and binding affinity of ligands to benzodiazepine/GABAA receptors using artificial neural networks. (1995) (75)
- The specificity of strychnine as a glycine antagonist in the mammalian spinal cord (1971) (74)
- Brain γ-aminobutyric acid receptor binding is normal in rats with thioacetamide-induced hepatic encephalopathy despite elevated plasma γ-aminobutyric acid-like activity (1987) (73)
- Regional Heterogeneity of L‐Glutamate and L‐Aspartate High‐Affinity Uptake Systems in the Rat CNS (1991) (69)
- (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors. (2005) (67)
- Potency of GABA at human recombinant GABAA receptors expressed in Xenopus oocytes: a mini review (2013) (65)
- Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA (2015) (65)
- Stress and GABAA receptors (2010) (64)
- Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant α1β2γ2L GABAA receptors (2003) (64)
- Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. (2015) (64)
- Deficit of spinal cord glycine/strychnine receptors in inherited myoclonus of Poll Hereford calves. (1988) (61)
- Muscimol as an Ionotropic GABA Receptor Agonist (2014) (61)
- Synthetic analogs for the study of GABA as a neurotransmitter (1983) (61)
- Dual Action of Pentobarbitone on GABA Binding: Role of Binding Site Integrity (1981) (60)
- Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant α1β2γ2L GABAA receptors (2004) (60)
- Bicuculline‐ and Baclofen‐Insensitive γ‐Aminobutyric Acid Binding to Rat Cerebellar Membranes (1992) (60)
- Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. (2003) (60)
- GABAC receptor antagonists differentiate between human ρ1 and ρ2 receptors expressed in Xenopus oocytes (1998) (58)
- GABA Receptors and Phospholipids (1978) (58)
- Enhancement by anesthetic and convulsant barbiturates of GABA binding to rat brain synaptosomal membranes (1981) (56)
- Natural and synthetic substances related to human health (IUPAC Technical Report) (2002) (55)
- Interactions of the Anticonvulsant Carbamazepine with Adenosine Receptors. 2. Pharmacological Studies (1983) (54)
- Glycine and spinal inhibition (1967) (54)
- 4-aminotetrolic acid: new conformational-restricted analogue of -aminobutyric acid. (1971) (53)
- THE OXIDATION OF GLYCINE BY d‐AMINO ACID OXIDASE IN EXTRACTS OF MAMMALIAN CENTRAL NERVOUS TISSUE (1969) (52)
- Neurochemical studies on quinolone antibiotics: effects on glutamate, GABA and adenosine systems in mammalian CNS. (1989) (51)
- Sex Differences in Acute Swim Stress‐Induced Changes in the Binding of MK‐801 to the NMDA Subclass of Glutamate Receptors in Mouse Forebrain (1993) (51)
- A Molecular Basis for Agonist and Antagonist Actions at GABAC Receptors (2008) (50)
- Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin‐Q (2011) (50)
- Identification of Functional Domains of the Human Glutamate Transporters EAAT1 and EAAT2* (1998) (49)
- Transamination of analogues of γ-aminobutyric acid by extracts of rat brain mitochondria (1973) (49)
- Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA (1989) (48)
- Sex Differences in the Effects of Acute Swim Stress on Binding to GABAA Receptors in Mouse Brain (1993) (47)
- (+)‐ and (‐)‐cis‐2‐Aminomethylcyclopropanecarboxylic Acids Show Opposite Pharmacology at Recombinant ρ1 and ρ2 GABAC Receptors (2000) (47)
- GABAA Receptors Containing ρ1 Subunits Contribute to In Vivo Effects of Ethanol in Mice (2014) (47)
- Alterations in Cortical [3H]Kainate and α‐[3H]Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Binding in a Spontaneous Canine Model of Chronic Hepatic Encephalopathy (1991) (46)
- Antagonism of neuronal excitation by 1-hydroxy-3-aminopyrrolidone-2. (1973) (46)
- 2′‐Methoxy‐6‐methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABAA receptors (2012) (46)
- Differences in uptake kinetics of cis-3-aminocyclohexane carboxylic acid into neurons and astrocytes in primary cultures (1983) (46)
- Effects of calcium on the potassium-stimulated release of radioactive β-alanine and γ-aminobutyric acid from slices of rat cerebral cortex and spinal cord (1977) (45)
- Flavan-3-ol derivatives are positive modulators of GABAA receptors with higher efficacy for the α2 subtype and anxiolytic action in mice (2008) (45)
- SEX DIFFERENCES IN THE EFFECTS OF GONADECTOMY AND ACUTE SWIM STRESS ON GABAA RECEPTOR BINDING IN MOUSE FOREBRAIN MEMBRANES (1997) (45)
- Flumazenil-independent positive modulation of γ-aminobutyric acid action by 6-methylflavone at human recombinant α1β2γ2L and α1β2 GABAA receptors (2004) (45)
- GABA Receptor Pharmacology (1995) (43)
- Inhibition of spinal neurons by glycine. (1967) (43)
- Pyrazolo[3,4-d]pyrimidines as adenosine antagonists. (1984) (43)
- Postnatal development of GABA binding sites and their endogenous inhibitors in rat brain. (1982) (43)
- Comparison of binding parameters of σ1 and σ2 binding sites in rat and guinea pig brain membranes: novel subtype-selective trishomocubanes (1996) (42)
- Pyrazolo [3,4-d] pyrimidines, a new class of adenosine antagonists (1983) (42)
- Glutamate and Huntington's Disease (1981) (42)
- TETANUS TOXIN AND AMINO ACID LEVELS IN CAT SPINAL CORD (1969) (39)
- Natural and synthetic substances related to human health (2002) (39)
- 6-Methylflavanone, a more efficacious positive allosteric modulator of γ-aminobutyric acid (GABA) action at human recombinant α2β2γ2L than at α1β2γ2L and α1β2 GABAA receptors expressed in Xenopus oocytes (2005) (39)
- 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes. (2011) (39)
- Stereoselective interaction of thiopentone enantiomers with the GABAA receptor (1999) (38)
- Unsaturated phosphinic analogues of γ-aminobutyric acid as GABAC receptor antagonists (1997) (38)
- Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors. (2012) (37)
- Flavonoids: some of the wisdom of sage? (2004) (37)
- Purines interact with ‘central’ but not ‘peripheral’ benzodiazepine binding sites (1982) (36)
- Idiospermuline, a trimeric pyrrolidinoindoline alkaloid from the seed of Idiospermum australiense. (1995) (36)
- A new synthesis, resolution and in vitro activities of (R)- and (S)-β-phenyl-GABA (1990) (36)
- Cortisol: A potent biphasic modulator at GABAA-receptor complexes in the guinea pig isolated ileum (1987) (36)
- Glycine:2-oxoglutarate transaminase in rat cerebral cortex. (1969) (34)
- (+)‐Hydrastine, a potent competitive antagonist at mammalian GABAA receptors (1990) (33)
- GABA Transporters GAT-1 and GAT-3 in the Human Dorsolateral Prefrontal Cortex in Schizophrenia (2004) (33)
- Novel oral drug administration in an animal model of neuroleptic therapy (2005) (33)
- Serine‐O‐sulphate transport by the human glutamate transporter, EAAT2 (1998) (33)
- trans‐4‐Amino‐2‐methylbut‐2‐enoic acid (2‐MeTACA) and (±)‐trans‐2‐aminomethylcyclopropanecarboxylic acid ((±)‐TAMP) can differentiate rat ρ3 from human ρ1 and ρ2 recombinant GABAC receptors (2002) (32)
- Uptake of γ-aminobutyric acid andl-glutamic acid by synaptosomes from postmortem human cerebral cortex: multiple sites, sodium dependence and effect of tissue preparation (1989) (32)
- Interactions of flavonoids with ionotropic GABA receptors. (2015) (32)
- GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators. (2019) (32)
- Effect of GABA-Fortified Oolong Tea on Reducing Stress in a University Student Cohort (2019) (32)
- Analogues of γ‐aminobutyric acid (GABA) and trans‐4‐aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists (1997) (32)
- Glutamate and related amino-acids in cat, dog, and rat spinal roots. (1970) (31)
- Chapter 8 GABAc receptors (1994) (31)
- Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. (2008) (31)
- d‐ASPARTATE OXIDASE ACTIVITY IN EXTRACTS OF MAMMALIAN CENTRAL NERVOUS TISSUE (1975) (31)
- Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy (1996) (30)
- Isothiouronium compounds as γ‐aminobutyric acid agonists (1986) (30)
- Differences in the interactions between GABA and benzodiazepine binding sites (1982) (30)
- Glutamate and imprinting memory: the role of glutamate receptors in the encoding of imprinting memory (1993) (29)
- Medicinal chemistry of ρ GABAC receptors. (2011) (29)
- Neurochemicals for the Investigation of GABAC Receptors (2010) (29)
- GABAB-receptor-mediated actions of baclofen in rat isolated neocortical slice preparations: antagonism by phosphono-analogues of GABA (1989) (29)
- Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake. (1975) (29)
- The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined (2007) (29)
- GABA‐ρ receptors: distinctive functions and molecular pharmacology (2017) (29)
- INHIBITION OF AMINO ACID TRANSMITTER RELEASE FROM RAT BRAIN SLICES BY PHENYTOIN AND RELATED ANTICONVULSANTS (1983) (29)
- Liberation of amino acids during the preparation of brain slices (1975) (28)
- 3-aminopropanephosphinic acid is a potent agonist at peripheral and central presynaptic GABAB receptors (1990) (28)
- Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors. (2003) (28)
- Inhibition of acetylcholinesterase by bicuculline and related alkaloids (1975) (27)
- Uptake of gamma-aminobutyric acid by human blood platelets: comparison with CNS uptake. (1985) (27)
- An improved, versatile synthesis of the GABAC antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA) (2001) (26)
- The effects of anaesthetic and convulsant barbiturates on the efflux of [3H]d-aspartate from brain minislices (1980) (26)
- Serine hydroxymethyltransferase in the central nervous system: regional and subcellular distribution studies (1973) (26)
- Charged Residues at the 2′ Position of Human GABAC ρ1 Receptors Invert Ion Selectivity and Influence Open State Probability* (2004) (26)
- Novel Cyclic Phosphinic Acids as GABAC ρ Receptor Antagonists: Design, Synthesis, and Pharmacology. (2011) (26)
- Molecular Biology, Pharmacology, and Physiology of GABAC Receptors (1997) (26)
- Benzofuran analogues of baclofen: a new class of central and peripheral GABAB-receptor antagonists. (1989) (25)
- Guanidino Acids Act as ρ1 GABAC Receptor Antagonists (2009) (25)
- Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. (2011) (25)
- GABA and barbiturate receptors (1982) (25)
- Modulation of GABA binding to rat brain membranes by alkyl beta-carboline-3-carboxylate esters. (1982) (25)
- GABA RECEPTORS: AS COMPLEX AS ABC? (1994) (25)
- Necropsy study of GABA/benzodiazepine receptor binding sites in brain tissue from chronic alcoholic patients. (1988) (25)
- Pentobarbitone slows the dissociation of GABA from rat brain synaptosomal binding sites (1981) (25)
- Contrasting regulation by GABA of the displacement of benzodiazepine antagonist binding by benzodiazepine agonists and purines (1982) (24)
- Conformational analysis of muscimol, a GABA agonist. (1979) (24)
- Inhibition of high affinity l-glutamic acid uptake into rat cortical synaptosomes by the conformationally restricted analogue of glutamic acid, cis-1-aminocyclobutane-1,3-dicarboxylic acid (1991) (24)
- Synthesis of Analogues of GABA. XIV. Synthesis and Activity of Unsaturated Derivatives of 5-Aminopentanoic Acid (d-Aminovaleric Acid) (1985) (24)
- Barbiturates and GABA receptors. (1981) (24)
- Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site (2011) (24)
- R-(-)-beta-phenyl-GABA is a full agonist at GABAB receptors in brain slices but a partial agonist in the ileum. (1993) (23)
- Strychnine, Glycine and Vertebrate Postsynaptic Inhibition (1970) (23)
- Regional and subcellular distribution studies on glycine:2-oxoglutarate transaminase activity in cat spinal cord. (1970) (23)
- Flavan‐3‐ol esters: new agents for exploring modulatory sites on GABAA receptors (2012) (23)
- Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone (2014) (23)
- Herbal Products and GABA Receptors (2009) (23)
- Routine screening and quantitation of urinary corticosteroids using bench-top gas chromatography-mass-selective detection. (1992) (23)
- The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABA(C) receptors. (2001) (23)
- GABAA Receptor Modulation by Compounds Isolated from Salvia triloba L. (2014) (22)
- Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. (2004) (22)
- Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. (2006) (22)
- Glycine-producing transaminase activity in extracts of spinal cord. (1969) (22)
- Cortical dihydrophyridine binding sites are unaltered in human alcoholic brain (1989) (22)
- Aza-THIP and related analogues of THIP as GABA C antagonists. (2003) (22)
- Regional differences in the inhibition of l-glutamate and l-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by l-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-d-aspartate and d-aspartate (1994) (22)
- Diazepam stimulates the binding of GABA and muscimol but not thip to rat brain membranes (1983) (22)
- Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen, 3-aminopropylphosphonic acid and related GABAB receptor antagonists (1990) (21)
- Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. (2009) (21)
- Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. (2008) (21)
- ADENOSINE RECEPTORS IN POST‐MORTEM HUMAN CEREBRAL CORTEX AND THE EFFECT OF CARBAMAZEPINE (1986) (21)
- Resolution of the stereoisomers of baclofen by high performance liquid chromatography (1984) (21)
- γ‐Aminobutyric Acid Receptor Ionophore Complexes: Differential Effects of Deltamethrin, Dichlorodiphenyltrichloroethane, and Some Novel Insecticides in a Rat Brain Membrane Preparation (1987) (21)
- A single amino acid determines the toxicity of Ginkgo biloba extracts (2012) (20)
- Differing actions of baclofen and 3-amino-propylphosphinic acid in rat neocortical slices (1990) (20)
- Allylglycine, an inhibitor of the uptake of l-leucine and l-proline in rat brain slices (1974) (20)
- GABAB antagonists: resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen. (1994) (20)
- Ionotropic GABA Receptors as Therapeutic Targets for Memory and Sleep Disorders (2004) (19)
- Identification of Benzopyran‐4‐one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors (2011) (19)
- Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAC receptor antagonists (2003) (19)
- Differing actions of β-phenyl-GABA and baclofen in the guinea pig isolated ileum (1987) (19)
- Interactions of carbamazepine with benzodiazepine receptors (1983) (18)
- Mutations of the 2′ proline in the M2 domain of the human GABAC ρ1 subunit alter agonist responses (2004) (18)
- Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists of ρ1 GABAC Receptors. (2013) (18)
- Profiling of urinary testosterone and luteinizing hormone in exercise-stressed male athletes, using gas chromatography-mass spectrometry and enzyme immunoassay techniques. (1996) (18)
- Central actions of shikimin and tutin. (1973) (17)
- (3-Aminocyclopentyl)methylphosphinic acids: Novel GABAC receptor antagonists (2007) (17)
- Resolution and conformational analysis of diastereoisomeric esters of cis- and trans-2-(aminomethyl)-1-carboxycyclopropanes (1998) (17)
- Increased γ‐Aminobutyric Acid Receptor Function in the Cerebral Cortex of Myoclonic Calves with an Hereditary Deficit in Glycine/Strychnine Receptors (1990) (17)
- Acute effects of lead at central synapses in vitro (1985) (17)
- Reduced adenosine deaminase activity in the CNS of spontaneously-hypertensive rats (1987) (17)
- Neuropharmacology: Propylene Glycol Elicits Anxiolytic‐like Responses to the Elevated Plus‐maze in Male Mice (1998) (17)
- Contrasting effects of a convulsant (CHEB) and an anticonvulsant barbiturate (phenobarbitone) on amino acid release from rat brain slices (1983) (17)
- Pregnenolone and its sulphate modulate GABAA-receptor-mediated contractile responses in the guinea-pig isolated ileum. (1987) (17)
- Comparison of binding parameters of sigma 1 and sigma 2 binding sites in rat and guinea pig brain membranes: novel subtype-selective trishomocubanes. (1996) (16)
- Phenobarbitone binding sites in rat brain synaptosomal membranes (1981) (16)
- X-Ray Crystallographic and Proton Magnetic Resonance Spectroscopic Investigations of Nipecotic Acid, a Potent Inhibitor of gamma-Aminobutyric Acid (GABA) Uptake. (1976) (16)
- The inactivation of extracellularly administered amino acids in the feline spinal cord (1970) (16)
- Bicuculline and GABA-metabolising enzymes. (1972) (16)
- Cortisone: a potent GABAA antagonist in the guinea‐pig isolated ileum (1990) (16)
- Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531). (2010) (15)
- GABAa AGONISTS AS TARGETS FOR DRUG DEVELOPMENT (1992) (15)
- Convulsant actions of calycanthine. (2003) (15)
- Long‐lasting effects of early‐life intervention in mice on adulthood behaviour, GABAA receptor subunit expression and synaptic clustering (2017) (14)
- Glutamate and aspartate as transmitters in the spinal cord. (1976) (14)
- Effects of bilobalide, ginkgolide B and picrotoxinin on GABAA receptor modulation by structurally diverse positive modulators (2017) (14)
- GABA(C) receptor antagonists differentiate between human rho1 and rho2 receptors expressed in Xenopus oocytes. (1998) (14)
- GABAA receptor cysteinyl mutants and the ginkgo terpenoid lactones bilobalide and ginkgolides. (2016) (13)
- Synaptosomal and brain slice cerebrocortical [3H]l-glutamate uptake in a rat model of chronic hepatic encephalopathy (1996) (13)
- Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. (2006) (13)
- Synthesis of analogues of γ-aminobutyric acid. Part 11. Unsaturated and saturated tetronic acid [furan-2,4(3H,5H)-dione] derivatives (1983) (13)
- Muscimol and the uptake of γ-aminobutyric acid by rat brain slices (2004) (13)
- Calcium dependence of baclofen- and GABA-induced depression of responses to transmural stimulation in the guinea-pig isolated ileum. (1987) (12)
- Neurotoxic Amino Acids (1974) (12)
- Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ρ1 receptor. (2012) (12)
- Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABAA receptor binding sites (2008) (12)
- ( + )-And ( )-borneol : efficacious positive modulators of GABA action at human recombinant a 1 b 2 g 2 L GABAA receptors (2005) (12)
- Alfaxalone potentiates and mimics GABA‐induced contractile responses in the guinea‐pig isolated ileum (1988) (12)
- Ethylenediamine as a GABA agonist: Enhancement of diazepam binding and interaction with GABA receptors and uptake sites (1982) (12)
- High affinity uptake of cyclic AMP in rat brain slices. (1973) (12)
- Stimulation of [3H]GABA and β‐[3H]Alanine Release from Rat Brain Slices by cis‐4‐Aminocrotonic Acid (1997) (11)
- Γ-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates. (2013) (11)
- GABA-enriched teas as neuro-nutraceuticals (2020) (11)
- Differentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ρ(1) receptors. (2012) (11)
- High affinity uptake of cAMP in rat brain: Inhibition by coronary vasodilators dilazep and hexobendine (1988) (11)
- Plasma gaba‐like activity in rats with hepatic encephalopathy is due to gaba and taurine (1990) (11)
- Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors (2012) (11)
- The preparation of tritiated E- and Z-4-aminobut-2-enoic acids, conformationally restricted analogues of the inhibitory neurotransmitter 4-aminobutanoic acid (GABA) (1993) (11)
- Synthesis and resolution of 2-methyl analogues of GABA (2004) (11)
- GABA, The Major Inhibitory Neurotransmitter in the Brain (2018) (11)
- Effect of ethanol on the GABA-benzodiazepine receptor in brain. (1987) (10)
- Central effects of beta-(para-chlorophenyl)-gamma-aminobutyric acid. (1974) (10)
- ZAPA, a substrate for the neuronal high affinity GABA uptake system in rat brain slices (1991) (10)
- Structural analogues of ZAPA as GABAA agonists (1997) (10)
- Enhancement of excitant amino acid release from rat brain slices by the convulsant 3-mercaptopropionic acid (1983) (10)
- Effects of Lead Salts on the Uptake, Release, and Binding of γ‐Aminobutyric Acid: The Importance of Buffer Composition (1989) (10)
- Gamma-aminobutyric acid-modulated benzodiazepine binding sites in bacteria. (1991) (9)
- Tautomerism of hydroxy-pyridazines: the N-oxides (1997) (9)
- Unsaturated phosphinic analogues of gamma-aminobutyric acid as GABA(C) receptor antagonists. (1997) (9)
- Receptor alterations associated with spinal motoneuron degeneration in Bovine Akabane disease (1990) (9)
- Novel γ-Aminobutyric Acid G1 Receptor Antagonists; Synthesis, Pharmacological Activity and Structure-Activity Relationships (2008) (9)
- Synthesis of analogues of GABA. IX. 5-(Aminomethyl)-3-hydroxyfuran-2(5H)-one (1983) (9)
- (+)- and (-)-cis-2-aminomethylcyclopropanecarboxylic acids show opposite pharmacology at recombinant rho(1) and rho(2) GABA(C) receptors. (2000) (9)
- Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. (2004) (9)
- Chiral derivatives of 2-cyclohexylideneperhydro-4,7-methanoindenes, a novel class of nonsteroidal androgen receptor ligand: synthesis, X-ray analysis, and biological activity. (2000) (9)
- Barbiturates and calcium-activated adenosine triphosphatase (1979) (9)
- Relative impact of residues at the intracellular and extracellular ends of the human GABAC rho1 receptor M2 domain on picrotoxinin activity. (2008) (8)
- Theoretical studies on the free-radical bromination of methyl-pyridazines in the synthesis of novel (1996) (8)
- Cyclobutane analogs of GABA (1980) (8)
- Interaction of purines and related compounds with photoaffinity-labelled benzodiazepine receptors in rat brain membranes. (1984) (8)
- 93. Constituents of the bark of Balanops australiana F. Muell (1962) (8)
- 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. (2005) (8)
- Molecular orbital and proton magnetic resonance studies of bicuculline. (1973) (8)
- Mixed antagonistic effects of bilobalide at ρ1 GABAC receptor (2006) (8)
- Vintage amino acid meeting describes new tools for amino acid research, subtypes of metabotropic receptors. (1991) (7)
- Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids (2016) (7)
- Synthesis of Unsaturated Analogues of Glutamic Acid: Amination of Trianions From Unsaturated Dicarboxylic Acids With Chloramine (1996) (7)
- Ontogeny of high affinity uptake of GABA studied in 'minislices' (tissue prisms) of rat cerebral cortex. (1989) (7)
- γ‐Aminobutyrylcholine and central inhibition (1972) (7)
- Metabolomic Approaches to Defining the Role(s) of GABAρ Receptors in the Brain (2015) (7)
- L-glutamate and γ-aminobutyric acid uptake in synaptosomes from the cerebral cortex of dogs with congenital chronic hepatic encephalopathy (1995) (7)
- Brain gamma-aminobutyric acid receptor binding is normal in rats with thioacetamide-induced hepatic encephalopathy despite elevated plasma gamma-aminobutyric acid-like activity. (1987) (7)
- Low nanomolar GABA effects at extrasynaptic a 4 b 1 / b 3 d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors (2012) (7)
- Stereospecific Actions of GABA Analogues (1979) (7)
- Medicinal chemistry and molecular pharmacology of GABA receptors and glutamate transporters—Complementary structure–activity relationships (1999) (6)
- Brain gaba receptor binding and plasma gaba-like activity in a model of chronic hepatic encephalopathy in rats (1986) (6)
- Flavonoid Actions on Receptors for the Inhibitory Neurotransmitter GABA (2017) (6)
- Uptake of gamma-aminobutyric acid and glycine by synaptosomes from postmortem human brain. (1986) (6)
- Differential modulation of γ-aminobutyric acid receptors by caprolactam derivatives with central nervous system depressant on convulsant activity (1985) (6)
- Sex differences in acute swim stress induced changes in the binding of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and kainate to glutamate receptors in mouse forebrain (1994) (6)
- Polyclonal Antibodies to the Glycine Receptor Antagonist Strychnine (1989) (6)
- Bicuculline- and baclofen-insensitive gamma-aminobutyric acid binding to rat cerebellar membranes. (1992) (6)
- Biochemistry of Glycine, Taurine, Glutamate, and Aspartate (1975) (6)
- Glycine Enzymes and Uptake Systems (1975) (6)
- Synapic depression and adenosine (1988) (5)
- Interactions of some anaesthetic, convulsant, and anticonvulsant drugs at GABA-benzodiazepine receptor-ionophore complexes in rat brain synaptosomal membranes (1983) (5)
- 640. Steroids and Walden inversion. Part XLVIII. The solvolysis of some 3-epimeric 4,4-dimethyl-steroid toluene-p-sulphonates (1961) (5)
- The synthesis of 2-cyclohexylideneperhydro-4,7-methanoindenes. Non-steroidal analogues of steroidal GABAA receptor modulators (1998) (5)
- Depolarizing actions of convulsant barbiturates on isolated rat dorsal root ganglion cells (1988) (5)
- 6-Methylflavone (2001) (4)
- GABA Analogues Derived from 4-Aminocyclopent-1-enecarboxylic Acid (2009) (4)
- Rand Lecture, ASCEPT. GABA receptors: as complex as ABC? Australaisian Society for Clinical and Experimental Pharmacologists and Toxicologists. (1994) (4)
- GABA Australis, some reflections on the history of GABA receptor research in Australia (2017) (4)
- Cerebellar [3H]kainate and [3H]ampa binding in dogs with congenital portosystemic encephalopathy (1991) (4)
- Sex-differences and stress : Effects on regional high and low affinity [ 3 H ] GABA binding (2008) (4)
- Direct excitant action of convulsant barbiturates (1981) (4)
- Purine enzyme inhibition fails to alter benzodiazepine receptor binding in brain (1988) (4)
- Increase in Plasma Gaba-Like Factor That Is Not Gaba Itself in Acute and Chronic Models of Hepatic-Encephalopathy in Rats (1986) (3)
- Cover Picture: Identification of Benzopyran‐4‐one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors (ChemMedChem 8/2011) (2011) (3)
- Effect of chronic exposure to lead on GABA binding in developing rat brain (1990) (3)
- The synthesis of 1,8-disubstituted 10,11-dihydrodibenz[b,f]oxepin-10-ones. analogues of anaesthetic steroids (1991) (3)
- Strychnine-like action of the convulsant barbiturate, CHEB (1985) (3)
- Effects of calcium on the potassium-stimulated release of radioactive beta-alanine and gamma-aminobutyric acid from slices of rat cerebral cortex and spinal cord. (1977) (3)
- Aminomethyl-2,6-difluorophenols as a novel class of increased lipophilicity GABA(C) receptor antagonists. (1999) (3)
- Targeting GABAC Receptors Improves Post-Stroke Motor Recovery (2021) (3)
- 239. Steroids and Walden inversion. Part L. Comparative studies of α-bromo- and αα′-dibromo-ketones derived from friedelin and from 5α-cholestan-6-one (1962) (3)
- Isothiouronium compounds as gamma-aminobutyric acid agonists. (1986) (3)
- A New Synthesis, Resolution and in vitro Activities of (R)- and (S)-β-Phenyl-GABA. (1990) (3)
- CNQX binding to non-NMDA glutamate receptors in canine cerebro-cortical crude synaptosomal membranes: Pharmacological characterization and comparison of binding parameters in dogs with congenital portosystemic encephalopathy and control dogs (1992) (3)
- Effects of a depressant/convulsant pair of glutarimides on neuronal activity in the isolated spinal cord of the immature rat (1985) (3)
- Actions of pentobarbitone and derivatives with modified 5-butyl substituents on GABA and diazepam binding to rat brain synaptosomal membranes (1983) (3)
- Configuration of bicuculline, a GABA antagonist. (1973) (2)
- Antagonists of Ionotropic Receptors for the Inhibitory Neurotransmitter GABA: Therapeutic Indications (2018) (2)
- GABA-Activated Ligand Gated Ion Channels: Medicinal Chemistry and Molecular Biology (2000) (2)
- Calcium-dependent actions of the convulsant barbiturate, CHEB, on transmitter release at the rat neuromuscular junction. (1990) (2)
- Microwave‐Enhanced Synthesis of 2,3,6‐Trisubstituted Pyridazines: Application to Four‐Step Synthesis of Gabazine (SR‐95531). (2011) (2)
- Brain extracts containing a Huntington disease antigen inhibit [3H]kainate binding and block synaptosomal amino acid transport (1993) (2)
- Synthesis of ?-Aminobutyric Acid Analogues (2010) (2)
- GABA receptors and related binding sites (1984) (2)
- Synthesis of analogues of γ-aminobutyric acid. XI: Unsaturated and saturated tetronic acid [furan-2,4(3H,5H)-dione] (1984) (2)
- [Inhibitory effect of glycine and similar amino acids on spinal neurons]. (1968) (2)
- The synthesis and resolution of tritiated 4‐amino‐3‐phenylbutanoic acid ([3H]R‐ and [3H]S‐β‐phenylgaba) (1993) (2)
- Aldehydic and Ketonic Monocarboxylic Acids and Related Compounds (1964) (2)
- 704. Steroids. Part XVI. The bromination of some 3-ketosteroids methylated in ring-A (1962) (2)
- Insecticide action on GABAergic Cl flux in insect central nervous system (1988) (2)
- SYNTHESIS OF ANALOGS OF GABA. III. ALL FOUR STEREOISOMERS OF 3-AMINOCYCLOPENTANECARBOXYLIC ACID AND A STEREOCHEMICAL CORRELATION WITH AMIDINOMYCIN (1980) (1)
- The origins and early history of neurochemistry and its societies (2020) (1)
- Synthesis of Analogues of GABA. Part 13. An Alternative Route to (Z)‐4‐Aminocrotonic Acid. (1986) (1)
- 516. Steroids and Walden inversion. Part LI. The solvolysis of 4,4-dimethylcholest-5-en-3α-yl toluene-p-sulphonate (1962) (1)
- Gabarins and the nexus between gamma amino butyric acid and benzodiazepine receptors (1984) (1)
- Glutamatergic neurotransmission in hepatic encephalopathy. (1993) (1)
- SYNTHESIS OF ANALOGS OF GABA. VI. STEREOISOMERS OF CIS-3-AMINOCYCLOHEXANECARBOXYLIC ACID (1982) (1)
- Protective effect of adenosine against hypoxic damage. Synaptic depression and adenosine. (1988) (1)
- Aminomethyl-2,6-difluorophenols as a Novel Class of Increased Lipophilicity GABAc Receptor Antagonists. (2000) (1)
- GLUTAMATE AND OTHER EXCITATORY AMINO ACIDS IN THE MAMMALIAN CNS (1976) (1)
- Metabolomic Approaches to Defining the Role(s) of GABAρ Receptors in the Brain (2015) (1)
- Effect of chronic lead treatment on the development of neuromuscular connections in the rat. (1987) (1)
- Transamination of analogues of gamma-aminobutyric acid by extracts of rat brain mitochondria. (1973) (1)
- Plasma GABA-like Factor in Hepatic Encephalopathy May Be Taurine. (1989) (1)
- Aliphatic Monohydroxy-monocarboxylic Acids and Related Compounds (1964) (1)
- Inhibitors of the glial uptake of beta-alanine in rat brain slices. (1976) (0)
- GABA receptors. (1981) (0)
- Chiral Derivatives of 2‐Cyclohexylideneperhydro‐4,7‐methanoindenes, a Novel Class of Nonsteroidal Androgen Receptor Ligand: Synthesis, X‐Ray Analysis, and Biological Activity. (2001) (0)
- Further promiscuity of phenylalkylamine Ca antagonists (1988) (0)
- Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids (2015) (0)
- Allylglycine, and inhibitor of the uptake of L-leucine and L-proline in rat brain slices. (1974) (0)
- The 33 rd Liversidge Lecture for the Royal Society of NSW Dietary Chemicals and Brain Function (0)
- DIFFERENTIAL SENSITIVITY DURING DEVELOPMENT OF GABA-MEDIATED SYNAPTIC TRANSMISSION TO A NEUROACTIVE STEROID IN RAT HIPPOCAMPUS AND CEREBELLUM (1996) (0)
- The Synthesis of 1,8‐Disubstituted 10,11‐Dihydrodibenz(b,f)oxepin‐10‐ ones. Analogues of Anaesthetic Steroids. (1992) (0)
- Some personal thoughts on the Australasian Society of Clinical and Experimental Pharmacologists in the 1980s. (2017) (0)
- S-71-5 Modulation of GABA receptors by endogenous steroids (1996) (0)
- GABA agonists (1984) (0)
- The Synthesis of 2-Cyclohexylideneperhydro-4,7-methanoindenes. Non-Steroidal Analogues of Steroidal GABAA Receptor Modulators. (1999) (0)
- Synthesis of Analogues of GABA. Part 14. Synthesis and Activity of Unsaturated Derivatives of 5‐Aminopentanoic Acid (δ‐Aminovaleric Acid). (1986) (0)
- Muscimol as an Ionotropic GABA Receptor Agonist (2014) (0)
- Poster Session: Ion channels (2004) (0)
- Optimising the transient expression of GABA(A) receptors in adherent HEK293 cells. (2019) (0)
- The interaction of a huntington disease factor with receptors for the neurotoxin kainic acid (1991) (0)
- A New Class of GABA Agonist. (1977) (0)
- Charge density studies as a tool in drug design (2002) (0)
- Neurotoxicity of kainate and the inactivation of L-glutamate in vivo [proceedings]. (1980) (0)
- Benzodiazepines, Flavonoids, and GABA (2021) (0)
- SYNTHESIS OF ANALOGS OF GABA. IX. 5-(AMINOMETHYL)-3-HYDROXYFURAN-2(5H)-ONE (1983) (0)
- P-570 ANTAGONISM OF GINKGO TERPENE TRILACTONES AT GABA RECEPTORS (2006) (0)
- Resolution and Conformational Analysis of Diastereoisomeric Esters of cis- and trans-2-(Aminomethyl)-1-carboxycyclopropanes. (2010) (0)
- 2476 – STEREOSPECIFIC ACTIONS OF GABA ANALOGUES (1978) (0)
- Potency of GABA at human recombinant GABAA receptors expressed in Xenopus oocytes: a mini review (2013) (0)
- An Improved, Versatile Synthesis of the GABAC Antagonists (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic Acid (TPMPA) (IX) and (Piperidin-4-yl)methylphosphinic Acid (P4MPA) (XI). (2002) (0)
- Effect of exercise combined with environmental humidity on the stress response profiles of urinary cortisol, cortisone, tetrahydrocortisol and tetrahydrocortisone (1994) (0)
- Non‐dopaminergic actions of quinpirole hydrochloride (LY 171555), a selective D2‐agonist, in the guinea‐pig isolated ileum (1988) (0)
- In vivo effects of GABA uptake inhibitors on the response of cat spinal neurones to GABA analogues [proceedings]. (1977) (0)
- Transporters (2004) (0)
- The Crystal Structures of 3-Hydroxybiuret and 3-Hydroxybiuret Hemihydrate. (1976) (0)
- Synthesis and Activity of a Potent N‐Methyl‐D‐aspartic Acid Agonist, trans‐1‐Aminocyclobutane‐1,3‐dicarboxylic Acid, and Related Phosphonic and Carboxylic Acids. (2010) (0)
- SYNTHESIS OF ANALOGS OF GABA. V. THE TRANS AND CIS ISOMERS OF SOME 4-AMINO-3-HALOBUT-2-ENOIC ACIDS (1980) (0)
- Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone (2013) (0)
- A textbook of drug design and development: edited by Povl Krogsgaard-Larsen and Hans Bundgaard, Harwood Academic Publishers, 1991. $170.00/ £90.00 hbk, $48.00/£24.00 pbk (v + 643 pages) ISBN 3 7186 5099 1 hbk, 3 7186 5100 9 pbk (1992) (0)
- In vitro and in vivo effects of pentobarbitone sodium (1982) (0)
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