Graham Le Gros

Q: What Schools Are Affiliated With Graham Le Gros

Graham Le Gros is affiliated with the following schools: Victoria University of Wellington, University of Auckland, University of New Zealand

Graham Le Gros's AcademicInfluence.com Rankings

Graham Le Gros

Biology

#13086

World Rank

#16611

Historical Rank

Immunology

#997

World Rank

#1021

Historical Rank

biology Degrees

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Biology

Graham Le Gros's Degrees

PhD Immunology University of New Zealand
Bachelors Microbiology University of New Zealand

Why Is Graham Le Gros Influential?

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According to Wikipedia, Graham Stephen Le Gros is a New Zealand immunologist. He is currently Director of the Malaghan Institute of Medical Research in Wellington, New Zealand and leads its Allergic and Parasitic Diseases Programme. He is also Research Director of the Vaccine Alliance Aotearoa New Zealand – Ohu Kaupare Huaketo and a Research Professor at Victoria University of Wellington.

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Graham Le Gros's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Disruption of the murine IL-4 gene blocks Th2 cytokine responses (1993) (1324)
Basophils Produce IL-4 and Accumulate in Tissues after Infection with a Th2-inducing Parasite (2004) (465)
Infection of Mice with Mycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia (1998) (442)
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells (2013) (424)
Interleukin-4 is required for the induction of lung Th2 mucosal immunity. (1995) (390)
Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia (1995) (272)
The role of CTLA‐4 in the regulation of T cell immune responses (1999) (243)
Differential T Cell Function and Fate in Lymph Node and Nonlymphoid Tissues (2002) (227)
Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus. (2003) (213)
Interleukin 7 is a T-cell growth factor. (1989) (197)
Farm exposure in utero may protect against asthma, hay fever and eczema (2008) (189)
Cutting Edge: Basophils Are Transiently Recruited into the Draining Lymph Nodes during Helminth Infection via IL-3, but Infection-Induced Th2 Immunity Can Develop without Basophil Lymph Node Recruitment or IL-3 (2009) (153)
Immune Responses of IL‐4, IL‐5, IL‐6 Deficient Mice (1995) (152)
Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils. (2007) (140)
Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade (1997) (140)
In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation (2008) (140)
c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation (2002) (135)
CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia (1997) (130)
The functional role of CD8+ T helper type 2 cells (1995) (130)
Lifelong farm exposure may strongly reduce the risk of asthma in adults (2007) (124)
ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms (2015) (122)
IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation. (2015) (121)
Basophils Are the Major Producers of IL-4 during Primary Helminth Infection (2011) (111)
Production of interleukin-4 and other cytokines following stimulation of mast cell lines and in vivo mast cells/basophils. (1991) (101)
Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells (1990) (100)
CTLA4 ligation attenuates AP‐1, NFAT and NF‐κB activity in activated T cells (1999) (89)
Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells. (2004) (85)
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes. (2020) (80)
Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8+ T Cells Independently of CD4+T Cell Help (1999) (78)
The Lung Is an Important Site for Priming CD4 T-Cell-Mediated Protective Immunity against Gastrointestinal Helminth Parasites (2010) (78)
Secreted Proteomes of Different Developmental Stages of the Gastrointestinal Nematode Nippostrongylus brasiliensis* (2014) (76)
c-Jun NH 2-Terminal Kinase ( JNK ) 1 and JNK 2 Have Distinct Roles in CD 8 T Cell Activation (2002) (74)
A key role for lung‐resident memory lymphocytes in protective immune responses after BCG vaccination (2010) (73)
CTLA-4 Blockade Enhances the Immune Response Induced by Mycobacterial Infection but Does Not Lead to Increased Protection (1999) (69)
Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection (2015) (68)
Blockade of CD28/B7 co‐stimulation by mCTLA4‐Hγ1 inhibits antigen‐induced lung eosinophilia but not Th2 cell development or recruitment in the lung (1997) (67)
The effect of delipidated deglycolipidated (DDMV) and heat-killed Mycobacterium vaccae in asthma. (2001) (60)
Can bacterial endotoxin exposure reverse atopy and atopic disease? (2004) (59)
Suppression of allergic airway disease using mycobacterial lipoglycans. (2004) (57)
IL‐4, IL‐5 and IL‐10 are not required for the control of M. bovis‐BCG infection in mice (1998) (56)
Interferon‐γ‐ and interleukin‐4‐producing T cells can be primed on dendritic cells in vivo and do not require the presence of B cells (1994) (56)
The role of Th2 type CD4+ T cells and Th2 type CD8+ T cells in asthma (1996) (54)
Helminth-Conditioned Dendritic Cells Prime CD4+ T Cells to IL-4 Production In Vivo (2014) (52)
Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen‐specific T‐helper type 2 cells (2004) (50)
Effector lymphoid tissue and its crucial role in protective immunity. (2005) (47)
Understanding the roles of basophils: breaking dawn (2012) (47)
The Differentiation of CD4+ T-Helper Cell Subsets in the Context of Helminth Parasite Infection (2014) (47)
Antibodies and IL-3 support helminth-induced basophil expansion (2012) (47)
Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells (2018) (46)
Macrophage-Derived Human Resistin Is Induced in Multiple Helminth Infections and Promotes Inflammatory Monocytes and Increased Parasite Burden (2015) (44)
CD326loCD103loCD11blo Dermal Dendritic Cells Are Activated by Thymic Stromal Lymphopoietin during Contact Sensitization in Mice (2014) (42)
Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps. (2020) (42)
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization (2021) (41)
Role of Eosinophils in the Pathogenesis ofMycobacterium bovis BCG Infection in Gamma Interferon Receptor-Deficient Mice (2000) (40)
Epigenetic regulation of Th2 cytokine expression in atopic diseases. (2008) (39)
Differential requirements for IL‐4/STAT6 signalling in CD4 T‐cell fate determination and Th2‐immune effector responses (2010) (38)
-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8 T Cell Activation (2002) (33)
Preproenkephalin is a Th2 cytokine but is not required for Th2 differentiation in vitro (1999) (33)
Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy. (2014) (32)
Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites (2018) (31)
IL‐4 Differentiates Naive CD8+ T Cellsto a “Th2‐Like” Phenotype:A Link Between Viral Infections & Bronchial Asthma (1996) (31)
Eosinophils Determine Dermal Thickening and Water Loss in an MC903 Model of Atopic Dermatitis. (2018) (30)
Staphylococcal‐derived superantigen enhances peanut induced Th2 responses in the skin (2012) (30)
Absence of airway inflammation in a large proportion of adolescents with asthma (2016) (29)
Infection of mice with Mycobacterium bovis-BCG induces both Th1 and Th2 immune responses in the absence of interferon-gamma signalling. (1999) (28)
Identification of potential CD8+ T-cell epitopes of the 19 kDa and AhpC proteins from Mycobacterium tuberculosis. No evidence for CD8+ T-cell priming against the identified peptides after DNA-vaccination of mice. (1998) (27)
Allergen-Specific CTL Require Perforin Expression To Suppress Allergic Airway Inflammation (2012) (27)
De novo assembly of the complex genome of Nippostrongylus brasiliensis using MinION long reads (2018) (26)
IL‐25 exhibits disparate roles during Th2‐cell differentiation versus effector function (2014) (25)
New concepts of IgE regulation. (1991) (25)
Basophils: A Potential Liaison between Innate and Adaptive Immunity. (2006) (24)
Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection (2012) (24)
Secretory products from infective forms of Nippostrongylus brasiliensis induce a rapid allergic airway inflammatory response (2005) (23)
The Study of Host Immune Responses Elicited by the Model Murine Hookworms Nippostrongylus brasiliensis and Heligmosomoides polygyrus (2017) (22)
Evaluating the in vivo Th2 priming potential among common allergens. (2013) (22)
A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development (2018) (20)
ILC2s—Trailblazers in the Host Response Against Intestinal Helminths (2019) (20)
IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice (2017) (19)
The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils (2019) (19)
Immature murine NKT cells pass through a stage of developmentally programmed innate IL‐4 secretion (2012) (19)
High-dimensional analysis of intestinal immune cells during helminth infection (2020) (18)
Diverse innate stimuli activate basophils through pathways involving Syk and IκB kinases (2021) (17)
New Zealand’s science-led response to the SARS-CoV-2 pandemic (2021) (17)
Th2-dependent airway eosinophilia is regulated by preproenkephalin (2000) (17)
IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin (2018) (16)
Basophils promote barrier dysfunction and resolution in the atopic skin. (2021) (15)
Toll-Like Receptor 4, but Not Neutrophil Extracellular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis (2017) (14)
Critical role of preproenkephalin in experimental autoimmune encephalomyelitis (2006) (14)
CD8+ T cells and immunoregulatory networks in asthma (2004) (14)
IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses (2013) (13)
The role of ILC2 in hookworm infection (2018) (13)
Innate immunity: Mast cells in the front line (1996) (13)
Mycobacterium‐based vaccines for the prevention of allergic disease: a progress report (2002) (12)
Absence of preproenkephalin increases the threshold for T cell activation (2003) (12)
Viral infection and allergy (2004) (11)
Development of an asthma vaccine: research into BCG. (2000) (11)
Annotated mitochondrial genome with Nanopore R9 signal for Nippostrongylus brasiliensis (2017) (11)
Analysis of Two IL-4 Promoter Polymorphisms in a Cohort of Atopic and Asthmatic Subjects (1999) (10)
Expression of receptors for atrial natriuretic peptide on the murine bone marrow-derived stromal cells. (1992) (9)
Genetic regulation of antibody responsiveness to immunization in substrains of BALB/c mice (2018) (8)
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands (1994) (8)
Mucosal trapping and degradation of Nippostrongylus brasiliensis occurs in the absence of STAT6 (2013) (7)
Development of an Asthma Vaccine (2000) (7)
Immune responses in Interleukin 4-deficient mice (1994) (6)
Tissue-specific immunity in helminth infections (2022) (6)
Immunity without innate lymphoid cells (2016) (6)
Mast cells in the front line. Innate immunity. (1996) (6)
Basophils: a potential liaison between innate and adaptive immunity. (2006) (5)
Immunogenicity of BNT162b2 COVID-19 vaccine in New Zealand adults (2022) (4)
Tissue localization and frequency of antigen‐specific effector CD4+ T cells determines the development of allergic airway inflammation (2005) (4)
The Gastrointestinal Helminth Heligmosomoides bakeri Suppresses Inflammation in a Model of Contact Hypersensitivity (2020) (4)
Comment on: Repositioning TH cell polarization from single cytokines to complex help (2022) (3)
Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation. (2006) (3)
Editorial: The Role of Innate Lymphoid Cells in Mucosal Immunity (2020) (3)
How epigenetic imprinting contributes to stabilizing the Th2 phenotype (2012) (3)
Isolation of Nippostrongylus brasiliensis Larvae from Mouse Lungs (2016) (3)
Basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3 but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3 (86.19) (2010) (2)
The case for New Zealand to have its own COVID-19 vaccine programme. (2020) (2)
Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites (2018) (2)
Farm Exposures in Utero May Protect Against Asthma, Hay Fever and Eczema: a Cross Sectional Study in New Zealand (2006) (2)
Single-cell analysis of intestinal immune cells during helminth infection (2019) (2)
Publisher Correction: Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes (2021) (2)
Contents, Vol. 94, 1991 (1991) (1)
Discussion Session A: The early life origins of asthma (1998) (1)
Cutaneous immuno-surveillance and regulation of inflammation by group 2 innate lymphoid cells (P6374) (2013) (1)
The lung is an important site for priming CD 4 T cell mediated 2 protective immunity against gastrointestinal helminth parasites . 3 Running title : The lung is an important site for protective immunity against 4 parasites (2010) (1)
BCL6 deletion in CD4 T cells does not affect Th2 effector mediated immunity in the skin (2022) (1)
Dye Labeling of Live Nippostrongylus brasiliensis Larvae for Visualization in Host Tissue (2016) (1)
Interleukin-4: production by mast cell lines and by non-B, non-T cells. (1990) (1)
Large Particle Sorting to Isolate Live Parasitic Nematode Eggs (2016) (1)
β‐Glucan receptors on IL‐4 activated macrophages are required for hookworm larvae recognition and trapping (2022) (1)
Contents, Vol. 94, 1991 (1991) (1)
The skin environment controls local dendritic cell differentiation and function through innate IL-13 (2021) (1)
From Hygiene Hypothesis to Novel Allergic Asthma Therapeutics (2003) (1)
Airway Inflammation in Childhood Asthma: The Contribution of Non-allergic Mechanisms (2006) (1)
Bacterial Superantigen Elicits Food-Induced Allergic Sensitization through Epicutaneous Exposure (2010) (1)
Biographical Sketch of Dr. Alec H. Sehon (1991) (0)
De novo assembly of the complex genome of Nippostrongylus brasiliensis using MinION long reads (2018) (0)
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization (2022) (0)
Editorial: New roles for CD4+T cells in type 2 immune responses (2023) (0)
Robust immunogenicity of a third BNT162b2 vaccination against SARS-CoV-2 Omicron variant in a naive New Zealand cohort (2023) (0)
Immune profiling, microbiome, metabolomics, and gut physiology of a 1-year controlled human hookworm infection (2023) (0)
Author response: High-dimensional analysis of intestinal immune cells during helminth infection (2019) (0)
316 A unique population of dermal conventional dendritic cells enhances TH2 and inhibits TH17 cell polarization in healthy skin (2022) (0)
De novo long-read assembly of a complex animal genome (2017) (0)
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes (2021) (0)
Recruitment or IL-3 Develop without Basophil Lymph Node Infection-Induced Th2 Immunity Can during Helminth Infection via IL-3, but Recruited into the Draining Lymph Nodes Cutting Edge: Basophils Are Transiently (2009) (0)
Dialogue Between Neutrophils And Hookworms Determines Parasite Development (2017) (0)
Biographical Sketch of Dr. Alec H. Sehon (1991) (0)
Acknowledgements (1997) (0)
The human protein resistin drives detrimental inflammatory monocyte responses in helminth infection (MPF7P.710) (2015) (0)
The Functional Role of CD 8 + T Helper Type 2 Cells (2003) (0)
This information is current as IgE Responses against Allergens in Mice IL-4 Haploinsufficiency Specifically Impairs (2017) (0)
Schistosoma japonicum Is Less Sensitive to Cyclosporin A In Vivo Than Schistosoma (1999) (0)
A digital nanoscope for the genome (2017) (0)
The Differentiation and Function of Th2 and Th9 Cells (2016) (0)
Dendritic cells in Th2 immune responses (P1313) (2013) (0)
Mode of Action of Interleukins (1986) (0)
Edinburgh Research Explorer Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection Providing (2018) (0)
159 Rewriting the Paradigm for IL4/STAT6 and Th2 Differentiation. New Rules for In Vivo Commitment (2007) (0)
InflammationExpression To Suppress Allergic Airway Allergen-Specific CTL Require Perforin (2012) (0)
Immunity to helminth infection (PP-091) Chairperson: Tomohiro Yoshimoto (2010) (0)
during Primary Helminth Infection Basophils Are the Major Producers of IL-4 (2011) (0)
Airway sensory nerve sensitivity in adolescents with eosinophilic and non-eosinophilic asthma (2020) (0)
New data, new analyses – getting hooked into a MinION (2016) (0)
in Mice Lymphopoietin during Contact Sensitization Cells Are Activated by Thymic Stromal Dermal Dendritic lo CD11b lo CD103 lo CD326 (2014) (0)
Helminth-conditioned dendritic cells prime CD4+ T cells to IL4 production in vivo (IRC5P.469) (2014) (0)
Assembling genomes with complex genomic repeats (2017) (0)
EDITORIALS Funding health services for older people Richard (2002) (0)
Viral infection and allergy (multiple letters) [1] (2004) (0)
Immunity to helminth infection (WS-091) Chairpersons: Tomohiro Yoshimoto, Graham LeGros (2010) (0)
IL-25 alters gut microbiota and limits experimental colitis (2014) (0)
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization (2022) (0)

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Other Resources About Graham Le Gros

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What Schools Are Affiliated With Graham Le Gros?

Graham Le Gros is affiliated with the following schools:

Graham Le Gros's Academic­Influence.com Rankings