Grahame Hardie

Q: What Schools Are Affiliated With Grahame Hardie

Grahame Hardie is affiliated with the following schools: Imperial College London, University of Bristol, University of Oxford, University of Dundee, Columbia University, Brigham Young University, Heriot-Watt University, University of Cambridge

Grahame Hardie's AcademicInfluence.com Rankings

Grahame Hardie

Biology

#2314

World Rank

#3691

Historical Rank

Biochemistry

#189

World Rank

#239

Historical Rank

biology Degrees

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Biology

Grahame Hardie's Degrees

PhD Biochemistry University of Dundee

Why Is Grahame Hardie Influential?

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According to Wikipedia, Grahame Hardie FRS, FRSE, FMedSci is a Scottish biochemist, and Professor of Cellular Signalling, at the School of Life Sciences, University of Dundee. Career and research He was a member of the Faculty of 1000. He is the father of AMPK.

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Grahame Hardie's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

AMPK: a nutrient and energy sensor that maintains energy homeostasis (2012) (3439)
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (2005) (2804)
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy (2007) (2137)
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade (2003) (1547)
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. (2005) (1537)
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? (1998) (1521)
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011) (1352)
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 (2004) (1295)
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling (2007) (1255)
Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase* (1996) (1243)
The mechanisms of action of metformin (2017) (1235)
5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? (1995) (1189)
The AMP-activated protein kinase pathway – new players upstream and downstream (2004) (1149)
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. (1997) (1005)
AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes. (1999) (994)
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. (2003) (950)
Metabolism of inflammation limited by AMPK and pseudo-starvation (2013) (920)
Management of cellular energy by the AMP‐activated protein kinase system (2003) (853)
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. (1996) (825)
AMP‐activated protein kinase – development of the energy sensor concept (2006) (822)
5‐Aminoimidazole‐4‐Carboxamide Ribonucleoside (1995) (818)
The AMP-activated protein kinase--fuel gauge of the mammalian cell? (1997) (799)
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism (1989) (793)
AMP‐activated protein kinase: the energy charge hypothesis revisited (2001) (793)
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. (2004) (719)
The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase (2012) (678)
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. (2002) (662)
AMPK: a key regulator of energy balance in the single cell and the whole organism (2008) (658)
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin (2013) (648)
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. (2000) (648)
Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation (2010) (624)
5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2Cα and native bovine protein phosphatase‐2Ac (1995) (617)
AMPK: Sensing Glucose as well as Cellular Energy Status. (2017) (610)
AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. (2016) (609)
AMP-Activated Protein Kinase (1997) (571)
A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis (1987) (545)
AMPK: a key sensor of fuel and energy status in skeletal muscle. (2006) (534)
Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase. (2001) (494)
Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis (2007) (483)
Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase* (2005) (473)
AMPK--sensing energy while talking to other signaling pathways. (2014) (470)
Use of Cells Expressing gamma Subunit Variants to Identify Diverse Mechanisms of AMPK Activation (2010) (459)
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. (1998) (456)
5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms (*) (1995) (449)
Role of the AMP-activated protein kinase in the cellular stress response (1994) (447)
Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. (1989) (439)
AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation (2013) (428)
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. (1998) (427)
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes (2010) (421)
Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase* (2007) (416)
The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor (2009) (413)
Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. (1989) (406)
AMP-activated protein kinase as a drug target. (2007) (400)
AMPK: positive and negative regulation, and its role in whole-body energy homeostasis. (2015) (396)
Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio (1996) (394)
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK (2017) (389)
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. (2000) (385)
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. (2004) (381)
AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer (2013) (380)
AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge. (1999) (369)
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer. (2010) (369)
A Novel Domain in AMP-Activated Protein Kinase Causes Glycogen Storage Bodies Similar to Those Seen in Hereditary Cardiac Arrhythmias (2003) (353)
Dual regulation of the AMP‐activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle (1998) (345)
Sensing of energy and nutrients by AMP-activated protein kinase. (2011) (340)
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes (2006) (338)
AMP-activated protein kinase: a target for drugs both ancient and modern (2012) (337)
Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle. (2003) (333)
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. (2004) (332)
Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase I (1995) (327)
The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase. (1989) (319)
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). (2002) (297)
PLANT PROTEIN SERINE/THREONINE KINASES: Classification and Functions. (1999) (295)
Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex (2003) (292)
AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control. (2020) (289)
Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial (2011) (288)
Two SNF1-related protein kinases from spinach leaf phosphorylate and inactivate 3-hydroxy-3-methylglutaryl-coenzyme A reductase, nitrate reductase, and sucrose phosphate synthase in vitro. (1999) (288)
Regulation of HMG‐CoA reductase: identification of the site phosphorylated by the AMP‐activated protein kinase in vitro and in intact rat liver. (1990) (281)
Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. (1989) (275)
LKB1 and AMPK and the cancer-metabolism link - ten years after (2013) (271)
New roles for the LKB1-->AMPK pathway. (2005) (268)
Protein phosphorylation: a practical approach (1993) (266)
Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle. (2002) (266)
AMP‐activated protein kinase: a cellular energy sensor that comes in 12 flavours (2016) (263)
Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. (1988) (262)
The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading. (2004) (254)
5′-AMP-activated Protein Kinase Phosphorylates IRS-1 on Ser-789 in Mouse C2C12 Myotubes in Response to 5-Aminoimidazole-4-carboxamide Riboside* (2001) (251)
Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. (1997) (250)
The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro (1996) (248)
Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase. (1990) (248)
Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase. (1997) (247)
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels (2016) (244)
AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels (2014) (235)
AMP-Activated Kinase Regulates Cytoplasmic HuR (2002) (233)
Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase. (1986) (222)
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. (2000) (221)
Role of AMP‐activated protein kinase in the metabolic syndrome and in heart disease (2008) (218)
Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion. (1991) (211)
Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5'-AMP. (1999) (204)
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. (2012) (195)
Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Calcium Signaling in O2-sensing Cells?* (2005) (190)
AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels. (2014) (190)
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. (2007) (187)
AMPK and autophagy get connected (2011) (187)
Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase. (2000) (186)
Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase. (1992) (181)
Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells (2014) (180)
Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate. (2002) (178)
The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism (1989) (176)
Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets. (1992) (172)
AMP-activated protein kinase: a key system mediating metabolic responses to exercise. (2004) (169)
Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise. (2003) (169)
Histological evaluation of AMPK signalling in primary breast cancer (2009) (167)
Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle. (2009) (166)
Purification of the AMP-activated protein kinase on ATP-gamma-sepharose and analysis of its subunit structure. (1994) (165)
AMP-activated protein kinase: also regulated by ADP? (2011) (165)
Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase. (1989) (163)
Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase. (1999) (161)
Use of okadaic acid to inhibit protein phosphatases in intact cells. (1991) (160)
AMP-activated Protein Kinase Mediates Carotid Body Excitation by Hypoxia* (2007) (156)
5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle. (2004) (155)
AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer. (2011) (155)
Analysis of the LKB1-STRAD-MO25 complex (2004) (155)
5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle. (2003) (151)
Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles. (2002) (151)
Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. (2005) (150)
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase (2010) (143)
AICA riboside both activates AMP‐activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus (2004) (142)
The low activity of acetyl‐CoA car☐ylase in basal and glucagon‐stimulated hepatocytes is due to phosphorylation by the AMP‐activated protein kinase and not cyclic AMP‐dependent protein kinase (1988) (142)
Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP (2009) (141)
Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms (2015) (138)
Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism (2010) (137)
AMPK and Raptor: matching cell growth to energy supply. (2008) (132)
Keeping the home fires burning†: AMP-activated protein kinase (2018) (132)
AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System (2017) (130)
Molecular Pathways: Is AMPK a Friend or a Foe in Cancer? (2015) (129)
AMP‐activated protein kinase – a sensor of glycogen as well as AMP and ATP? (2009) (129)
Bacterial expression of the catalytic domain of 3-hydroxy-3-methylglutaryl-CoA reductase (isoform HMGR1) from Arabidopsis thaliana, and its inactivation by phosphorylation at Ser577 by Brassica oleracea 3-hydroxy-3-methylglutaryl-CoA reductase kinase. (1995) (125)
Insulin antagonizes AMP‐activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides (2001) (124)
Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes. (2003) (123)
The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. (1996) (121)
A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. (2002) (120)
AMPK: a cellular energy sensor primarily regulated by AMP. (2014) (119)
AMP‐activated protein kinase: a key regulator of energy balance with many roles in human disease (2014) (117)
Neither LKB1 nor AMPK are the direct targets of metformin. (2006) (117)
Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability (2011) (116)
Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase. (1992) (114)
Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle (2009) (113)
Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle. (2002) (112)
Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet. (2005) (111)
AMP-Activated Protein Kinase: A Master Switch in Glucose and Lipid Metabolism (2004) (110)
Normal hypertrophy accompanied by phosphoryation and activation of AMP‐activated protein kinase α1 following overload in LKB1 knockout mice (2008) (110)
Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK (2014) (109)
The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1 (1999) (106)
AMP-activated Protein Kinase Mediates Phenobarbital Induction of CYP2B Gene Expression in Hepatocytes and a Newly Derived Human Hepatoma Cell Line* (2005) (106)
A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion. (2002) (104)
AMPK regulation of mouse oocyte meiotic resumption in vitro. (2006) (104)
Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells* (2012) (103)
Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP (2014) (103)
AMP-activated protein kinase: the guardian of cardiac energy status. (2004) (102)
Identification of a novel proline-directed serine/threonine protein kinase in rat pheochromocytoma. (1989) (102)
Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle (2013) (99)
AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production (2007) (99)
Molecular pathways (2016) (98)
5-Aminoimidazole-4-Carboxamide 1-β-d-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men (2007) (98)
Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α (2014) (97)
Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise. (2006) (96)
Analysis of the role of the AMP-activated protein kinase in the response to cellular stress. (2000) (95)
Roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress. (1999) (93)
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. (1997) (92)
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. (2008) (90)
Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress. (1994) (89)
Specificity determinants for the AMP‐activated protein kinase and its plant homologue analysed using synthetic peptides (1993) (89)
Regulation of hormone‐sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise (2004) (88)
AMP-activated protein kinase : greater AMP dependence , and preferential nuclear localization , of complexes containing the α 2 isoform (1998) (88)
Regulation of AMP-activated protein kinase by natural and synthetic activators (2016) (87)
Fatty acid synthase — an example of protein evolution by gene fusion (1984) (86)
AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes. (2004) (86)
Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues. (1994) (85)
Control of carbohydrase formation by gibberellic acid in barley endosperm (1975) (85)
Advance of mitosis by histone phosphokinase. (1976) (84)
Reversible phosphorylation and inactivation of acetyl-CoA carboxylase from lactating rat mammary gland by cyclic AMP-dependent protein kinase. (1980) (83)
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress (2019) (82)
Role of 5′AMP‐activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease (2002) (80)
Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans. (2005) (80)
Characterization of the sites phosphorylated on tyrosine hydroxylase by Ca2+ and phospholipid‐dependent protein kinase, calmodulin‐dependent multiprotein kinase and cyclic AMP‐dependent protein kinase (1985) (79)
Glucagon inhibits fatty acid synthesis in isolated hepatocytes via phosphorylation of acetyl-CoA carboxylase by cyclic-AMP-dependent protein kinase. (1984) (77)
LKB 1 is a master kinase that activates 13 protein kinases of the AMPK subfamily , including the MARK / PAR-1 kinases (2004) (77)
The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?† (2019) (74)
PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion. (2006) (74)
AMP-activated protein kinase – not just an energy sensor (2017) (73)
PD98059 and U0126 activate AMP‐activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway (2005) (73)
Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase. (2011) (72)
Biochemical Characterization of the Tobacco 42-kD Protein Kinase Activated by Osmotic Stress1[w] (2004) (71)
AMPK: mediating the metabolic effects of salicylate-based drugs? (2013) (71)
Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation (2014) (69)
Pseudosubstrates turn off protein kinases (1988) (69)
The LKB1-AMPK pathway-friend or foe in cancer? (2013) (69)
Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice (2008) (68)
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK (2019) (68)
Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibres (2006) (68)
Evidence That Barley 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Kinase Is a Member of the Sucrose Nonfermenting-1-Related Protein Kinase Family (1996) (67)
Phenformin and 5‐aminoimidazole‐4‐carboxamide‐1‐β‐D‐ribofuranoside (AICAR) activation of AMP‐activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells (2005) (67)
Phosphorylation and inactivation of HMG‐CoA reductase at the AMP‐activated protein kinase site in response to fructose treatment of isolated rat hepatocytes (1992) (66)
Phosphorylation-dependent Translocation of Glycogen Synthase to a Novel Structure during Glycogen Resynthesis* (2005) (66)
Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing. (2011) (65)
C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest* (2009) (65)
The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA. (1995) (64)
Isolation of specific antibody under conditions of low ionic strength. (1977) (62)
De‐phosphorylation of MyoD is linking nerve‐evoked activity to fast myosin heavy chain expression in rodent adult skeletal muscle (2007) (61)
Intracellular ATP Influences Synaptic Plasticity in Area CA1 of Rat Hippocampus via Metabolism to Adenosine and Activity-Dependent Activation of Adenosine A1 Receptors (2011) (60)
Selective Expression in Carotid Body Type I Cells of a Single Splice Variant of the Large Conductance Calcium- and Voltage-activated Potassium Channel Confers Regulation by AMP-activated Protein Kinase* (2011) (60)
Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP‐dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis. (1985) (60)
Identification of Raf‐1 Ser621 kinase activity from NIH 3T3 cells as AMP‐activated protein kinase (1997) (59)
Both insulin and epidermal growth factor stimulate fatty acid synthesis and increase phosphorylation of acetyl‐CoA carboxylase and ATP‐citrate lyase in isolated hepatocytes (1985) (58)
Evidence that amiloride antagonises insulin‐stimulated protein phosphorylation by inhibiting protein kinase activity (1983) (58)
Fatal Infantile Cardiac Glycogenosis with Phosphorylase Kinase Deficiency and a Mutation in the γ2-Subunit of AMP-Activated Protein Kinase (2007) (57)
Purification and physicochemical properties of ATP citrate (pro-3S) lyase from lactating rat mammary gland and studies of its reversible phosphorylation. (1981) (57)
HIV-1 : Fifteen Proteins and an RNA (2006) (57)
Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection. (2011) (56)
AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner (2020) (56)
The protein phosphatases involved in cellular regulation. 3. Fatty acid synthesis, cholesterol synthesis and glycolysis/gluconeogenesis. (1983) (56)
Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase. (1988) (55)
Regulation of AMP‐activated protein kinase by a pseudosubstrate sequence on the γ subunit (2007) (55)
The Laforin–Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase β Subunits (2010) (55)
Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activation (2007) (55)
Identification by molecular cloning of two cDNA sequences from the plant Brassica napus which are very similar to mammalian protein phosphatases‐1 and ‐2A (1990) (55)
The AMP‐activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle (1995) (54)
Immunological evidence that HMG‐CoA reductase kinase‐A is the cauliflower homologue of the RKIN1 subfamily of plant protein kinases (1995) (54)
Negative interactions between phosphorylation of acetyl‐CoA carboxylase by the cyclic AMP‐dependent and AMP‐activated protein kinases (1988) (53)
AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2 (2016) (52)
PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain. (2015) (52)
AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle (2015) (52)
Regulation of lipid metabolism by the AMP-activated protein kinase. (1997) (51)
Immunochemical studies of tobacco mosaic virus--II. Univalent and monogamous bivalent binding of IgG antibody. (1976) (51)
AMP‐activated protein kinase ‐ An archetypal protein kinase cascade? (1992) (49)
Pharmacological activators of AMP‐activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells (2007) (48)
Metabolic control: A new solution to an old problem (2000) (48)
Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method. (1996) (48)
AMPK and SNF1: Snuffing Out Stress (2007) (48)
Cell-cycle dependence of two nuclear histone kinase enzyme activities. (1976) (47)
Involvement of AMP‐activated protein kinase in fat depot‐specific metabolic changes during starvation (2005) (46)
CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation. (2017) (46)
Ion Channel Regulation by AMPK (2009) (46)
Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib (2017) (46)
Biochemical characterization of two forms of 3-hydroxy-3-methylglutaryl-CoA reductase kinase from cauliflower (Brassica oleracia). (1994) (45)
Purification and physicochemical properties of fatty acid synthetase and acetyl-CoA carboxylase from lactating rabbit mammary gland. (1978) (45)
AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells? (2013) (45)
Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes. (1990) (45)
Molecular cloning of higher-plant 3-oxoacyl-(acyl carrier protein) reductase. Sequence identities with the nodG-gene product of the nitrogen-fixing soil bacterium Rhizobium meliloti. (1992) (45)
The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase. (1991) (45)
Both insulin and epidermal growth factor stimulate lipogenesis and acetyl-CoA carboxylase activity in isolated adipocytes. Importance of homogenization procedure in avoiding artefacts in acetyl-CoA carboxylase assay. (1986) (44)
Organismal carbohydrate and lipid homeostasis. (2012) (43)
Dephosphorylation and activation of Acetyl‐CoA‐carboxylase from lactating rabbit mammary gland (1979) (43)
Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase? (2004) (42)
Association of AMP-activated Protein Kinase Subunits With Glycogen Particles as Revealed In Situ by Immunoelectron Microscopy (2009) (42)
Glycogen Content Regulates Peroxisome Proliferator Activated Receptor-∂ (PPAR-∂) Activity in Rat Skeletal Muscle (2013) (42)
AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway (2012) (42)
Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation (2019) (41)
Prevention of high-fat diet-induced muscular lipid accumulation in rats by α lipoic acid is not mediated by AMPK activation[S] (2010) (41)
AMP-activated protein kinase and hypoxic pulmonary vasoconstriction. (2008) (40)
A new assay procedure to study the induction of β-ketoacyl-ACP synthase I and II, and the complete purification of β-ketoacyl-ACP synthase I from developing seeds of oilseed rape (Brassica napus) (1989) (39)
Regulation of acetyl‐CoA carboxylase: identity of sites phosphorylated in intact cells treated with adrenaline and in vitro by cyclic AMP‐dependent protein kinase (1980) (37)
Balancing Cellular Energy (2007) (36)
Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet (2011) (36)
Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival (2017) (36)
Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade (2015) (34)
Site-specific phosphorylation of tyrosine hydroxylase after KCl depolarization and nerve growth factor treatment of PC12 cells. (1990) (33)
Biochemical Messengers: Hormones, Neurotransmitters and Growth Factors (1991) (33)
Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy (2021) (32)
Multidomain proteins : structure and evolution (1986) (32)
Roles of protein kinases and phosphatases in signal transduction. (1990) (32)
Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle. (2002) (31)
Mapping of catalytic domains and phosphorylation sites in the multifunctional pyrimidine-biosynthetic protein CAD. (1988) (31)
Calmodulin-dependent multifunctional protein kinase. Evidence for isoenzyme forms in mammalian tissues. (1986) (30)
A Conserved Sequence Immediately N-terminal to the Bateman Domains in AMP-activated Protein Kinase γ Subunits Is Required for the Interaction with the β Subunits* (2007) (29)
Mechanism of Activation of AMPK by Cordycepin (2020) (29)
Distinct type‐2A protein phosphatases activate HMGCoA reductase and acetyl‐CoA carboxylase in liver (1997) (29)
Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle. (2001) (29)
Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status (2009) (29)
Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity. (1984) (29)
Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C. (1988) (29)
Faculty Opinions recommendation of Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. (2006) (29)
AMPK - a nutrient and energy sensor with roles in diabetes, cancer and viral infection (2012) (28)
Rat mammary gland ATP‐citrate lyase is phosphorylated by cyclic AMP‐dependent protein kinase (1980) (28)
Signal transduction: How cells sense energy (2011) (27)
A Neural Protection Racket: AMPK and the GABAB Receptor (2007) (27)
AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells. (2006) (27)
Protein phosphorylation and dephosphorylation. (1989) (27)
Characterization of the phosphorylation of rat mammary ATP-citrate lyase and acetyl-CoA carboxylase by Ca2+ and calmodulin-dependent multiprotein kinase and Ca2+ and phospholipid-dependent protein kinase. (1986) (26)
Modulation of O(2) sensitive K (+) channels by AMP-activated protein kinase. (2009) (26)
SNF1-related protein kinase (snRK1) phosphorylates class I heat shock protein. (2004) (24)
Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-Mr effector and not by increased phosphorylation. (1986) (24)
PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle. (2010) (24)
Evidence that glucagon-mediated inhibition of acetyl-CoA carboxylase in isolated adipocytes involves increased phosphorylation of the enzyme by cyclic AMP-dependent protein kinase. (1985) (23)
The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria (2018) (23)
Plant protein-serine/threonine kinases: Classification into subfamilies and overview of function (2000) (23)
Ways of coping with stress (1994) (23)
Cloning of DNA encoding a catalytic subunit of SNF1-related protein kinase-1 (SnRK1-α1), and immunological analysis of multiple forms of the kinase, in spinach leaf (2001) (23)
Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R (2000) (22)
Biochemistry. Balancing cellular energy. (2007) (22)
AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer? (2020) (22)
The limit dextrinase from malted sorghum (Sorghum vulgare). (1976) (22)
The role of acetyl-CoA carboxylase phosphorylation in the control of mammary gland fatty acid synthesis during the starvation and re-feeding of lactating rats. (1986) (22)
Immunochemical studies of tobacco mosaic virus--I: refutation of the alleged homogeneous binding of purified antibody fragments. (1975) (22)
Mammalian fatty acid synthetase: evidence for subunit identity and specific removal of the thioesterase component using elastase digestion (1978) (22)
AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. (1999) (21)
Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation (2009) (21)
AMP‐activated protein kinase inhibits Kv1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation (2016) (20)
Why Starving Cells Eat Themselves (2011) (20)
Evidence against a role for phosphorylation/dephosphorylation in the regulation of acyl-CoA:cholesterol acyl transferase. (1992) (19)
Targeting an energy sensor to treat diabetes (2017) (18)
The multifunctional polypeptide chain of rabbit mammary fatty acid synthase contains a domain homologous with the acyl carrier protein of Escherichia coli. (1983) (18)
The multifunctional polypeptide chains of rabbit-mammary fatty-acid synthase. Stoichiometry of active sites and active-site mapping using limited proteolysis. (2005) (18)
AMP-Activated Protein Kinase: Friend or Foe in Cancer? (2020) (17)
Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to pulmonary artery constriction? (2006) (17)
Kinetic behavior of membrane-bound, irreversible enzyme systems: experimental and theoretical considerations. (1982) (17)
The role of ATM in response to metformin treatment and activation of AMPK. (2012) (17)
Metformin-acting through cyclic AMP as well as AMP? (2013) (17)
An emerging role for protein kinases: the response to nutritional and environmental stress. (1994) (16)
A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved. (2017) (16)
Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement. (2010) (16)
Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1 (2020) (15)
New insights into activation and function of the AMPK (2022) (15)
Regulation of mammalian acetyl‐CoA carboxylase (1981) (14)
Reaction of chloroacetyl‐CoA with rabbit fatty acid synthase (1982) (14)
Fat and phosphorylation - the role of covalent enzyme modification in lipid synthesis (1981) (14)
Yeast carbamoyl-phosphate-synthetase--aspartate-transcarbamylase multidomain protein is phosphorylated in vitro by cAMP-dependent protein kinase. (1990) (13)
AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen? (2020) (12)
University of Dundee LKB 1 and AMPK and the cancer-metabolism link-ten years after (2013) (12)
Amino acid sequence around the reactive serine residue of the thioesterase domain of rabbit fatty acid synthase. (1985) (12)
Ion channel regulation by the Lkb1‐AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level (2012) (12)
Observations of the action of limit dextrinases on amylopectin-like polysaccharides. (1973) (12)
Role of Protein Phosphorylation in the Regulation of Fatty Acid Synthesis in the Mammary Gland of the Lactating Rat (1987) (12)
Mammalian fatty acid synthase: a chimeric protein which has evolved by gene fusion. (1986) (11)
A viscometric assay for pullulanase-type, debranching enzymes. (1974) (11)
Glucose Starvation Blocks Translation at Multiple Levels. (2020) (10)
Cellular Functions of Protein Kinases (1995) (10)
Protein-serine kinases (1995) (10)
Isolation of a cyclic-AMP-independent protein kinase from rat liver and its effect on the enzymic activity of acetyl-CoA carboxylase (1986) (10)
Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity (2018) (10)
Signaling by AMP‐activated Protein Kinase (2007) (9)
Targeting the Core of Transcription (2010) (9)
AMPK as a direct sensor of long-chain fatty acyl–CoA esters (2020) (9)
The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis. (1986) (9)
AICAR acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men. (2007) (9)
Key roles for AMP-activated protein kinase in the function of the carotid body? (2008) (9)
Corrigendum to: PD98059 and U0126 activate AMP‐activated protein kinase by increasing the cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway (FEBS 29123) [FEBS Lett. 579 (2005) 236–240] (2005) (9)
Determination of avidity of anti-viral antibodies at 50% binding of antibody. (1979) (9)
Reply…The sugar sensing story (1999) (8)
Zhou et al. reply (2012) (8)
PDH-E1α Dephosphorylation and Activation in Human Skeletal Muscle During Exercise (2006) (8)
Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK. (2018) (7)
Endogenous phosphorylation of microsomal proteins in bovine corpus luteum. Tenfold activation by adenosine 3':5'-cyclic monophosphate. (1977) (7)
Does AMP-activated protein kinase couple hypoxic inhibition of oxidative phosphorylation to carotid body excitation? (2006) (7)
Effect of fiber type and nutritional state on AICAR and contraction stimulated glucose transport in rat skeletal muscle (2002) (6)
Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase. (1991) (6)
PGC-1 (cid:1) increases PDH content but does not change acute PDH regulation in mouse skeletal muscle (2010) (6)
Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to insulin-like growth factor 1, EGF, PMA and AICAR (2007) (6)
An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-α2 for Degradation. (2017) (6)
Handel: A Documentary Biography [Book Review] (1980) (5)
Mapping of radiolabeled peptides derived from proteolysis of polypeptides bound to nitrocellulose after "Western" blotting. (1986) (5)
Peptide assay of protein kinases and use of variant peptides to determine recognition motifs. (2000) (5)
AMP-activated protein kinase (AMPK) (2014) (4)
The First Messengers — Hormones, Neurotransmitters and Local Mediators (1991) (4)
Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis (2022) (4)
LKB1 and AMPK and the cancer-metabolism link - ten years after (2013) (4)
Acetyl-CoA carboxylase and fatty acid synthase from lactating rabbit and rat mammary gland. (1981) (4)
Hot stuff: thyroid hormones and AMPK (2010) (3)
Cell Surface Receptors — Signal Transduction (1991) (3)
Regulation of Acetyl-Coenzyme A Carboxylase by Phosphorylation-Dephosphorylation (1979) (3)
THE POTENTIAL ROLE FOR AMP-KINASE IN HYPOXIC CHEMOTRANSDUCTION OF RAT CAROTID BODY. (2004) (3)
AMPK – roles in nutrient sensing and in cancer (2014) (3)
A new protein kinase cascade (2014) (3)
Calcium/calmodulin-dependent protein kinase kinase 2 mediates pleiotropic effects of epidermal growth factor in cancer cells. (2022) (3)
Faculty Opinions recommendation of Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. (2009) (3)
Cloning of cDNA to rat mammary-gland fatty acid synthase mRNA. Evidence for the expression of two mRNA species during lactation. (1988) (3)
THE ROLE OF PROTEIN PHOSPHORYLATION IN THE COORDINATED CONTROL OF INTERMEDIARY METABOLISM (1979) (2)
Small molecules can have big effects on endurance. (2008) (2)
University of Dundee The mechanisms of action of metformin (2017) (2)
Rapid removal of one of the phosphorylation sites on acetyl-CoA carboxylase by limited proteolysis [proceedings]. (1980) (2)
AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology (2022) (2)
Fatty acid synthase: probing the structure of a multifunctional protein by limited proteolysis. (1985) (2)
Cell Surface Receptors — Protein Phosphorylation and Other Intracellular Events (1991) (2)
Protein kinases at the frontier (2001) (2)
Phosphorylation of branched-chain 2-oxo acid dehydrogenase complex in isolated hepatocytes. (1987) (2)
A novel growth factor sensitive protein kinase in pheochromocytoma. (1988) (2)
Insulin activation of acetyl-CoA carboxylase in isolated mammary acini from lactating rats fed a high-fat diet (1986) (2)
Flights of fancy (1990) (2)
β-Ketoacyl-acyl-carrier protein synthase from developing seeds of oilseed rape ( Brassica napus ) (1989) (2)
AMP-activated protein kinase – not just an energy sensor [version 1; peer review: 3 approved] (2019) (1)
100 years of the Warburg effect: a historical perspective. (2022) (1)
AMP-activated protein kinase - the key sensor of cellular energy charge (2001) (1)
Phosphorylation Sites on Tyrosine Hydroxylase (1987) (1)
Reactin' with activin (1991) (1)
Structure and Biosynthesis of First Messengers (1991) (1)
AMPK and autophagy get connected (1)
Regulation of lipid biosynthesis by the AMP-activated protein kinase and its role in the hepatocellular response to stress. (1996) (1)
Post-Translational Modifications in Plants: Roles of protein phosphorylation in animal cells (1993) (1)
AMPK: a sensor of glycogen as well as AMP and ATP? (2008) (1)
Introduction: Protein kinases—cellular switching mechanisms (1994) (1)
Protein kinases: edited by J.R. Woodgett, IRL Press at OUP, 1994, £55.00 (hbk)/£29.50 (pbk) (xvi + 273 pages) ISBN 0 19 963409 2 (hbk)/0 19 963408 4 (pbk) (1995) (1)
The regulation of enzyme activity by reversible phosphorylation. (1982) (1)
Modulation of Kv2.1 and Kv1.5 channels by AMP-activated protein kinase (AMPK) (2010) (1)
- Cellular Signalling C 43 HYPOXIC PULMONARY VASOCONSTRICTION : IS AMP-ACTIVATED PROTEIN KINASE THE PRIMARY METABOLIC SENSOR AND EFFECTOR ? (2005) (0)
Protein-tyrosine kinases (1995) (0)
aspects of cell function an energy sensor that regulates all -- AMP-activated protein kinase (2012) (0)
CHAPTER 88 – AMP-Activated Protein Kinase (2003) (0)
A Process in Cell Regulation: Protein Phosphorylation . Papers from a conference., Ora M. Rosen and Edwin G. Krebs, Eds. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., 1981. In two volumes. xl, 1422 pp., illus. $140. (1982) (0)
Global knockout of AMP‐activated protein kinase alpha subunits attenuates the hypoxic ventilatory response in mice (2010) (0)
Hormones and metabolic control: by David A. White, Bruce Middleton and Michael Baxter, Edward Arnold, 1984. £5.95 (vi + 106 pages) ISBN 0 713 14437 8 (1984) (0)
Part 1 : Acetyl-CoA Carboxylase The role of phosphorylation / dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis (2009) (0)
University of Dundee Isoform-specific AMPK association with TBC 1 D 1 is reduced by a mutation associated with severe obesity (2018) (0)
1 1 2 3 4 AMPK and TOR : the Yin and Yang of cellular nutrient sensing and growth control 5 6 (2020) (0)
Analyzing the multiple mechanisms by which drugs and other xenobiotic compounds activate AMP-activated protein kinase (2010) (0)
A process in cell regulation. (1982) (0)
Peptide hormone action: A practical approach : Edited by K. Siddle and J.C. Hutton; IRL Press; Oxford, 1991; xix + 256 pages; £22.95 (1991) (0)
University of Dundee A novel , de novo mutation in PRKAG 2 gene (2017) (0)
- AMPK: AMP-activated protein kinase (vertebrates) (HMG-CoA reductase kinase) (1995) (0)
Cell Surface Receptors — Analysis and Identification (1991) (0)
W08-P-012 Possible involvement of AMP-activated protein kinase in adipocytes in regulation of adiposity (2005) (0)
Faculty Opinions recommendation of Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation. (2017) (0)
AMP-ACTIVATED PROTEIN KINASE – A UBIQUITOUS SIGNALLING (2017) (0)
Introduction: Cell—Cell Signalling by Cytoplasmic Bridges (1991) (0)
How I Became a Biochemist (2007) (0)
Faculty Opinions recommendation of Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. (2007) (0)
Pharmacological activators of AMPK have differential effects on transepithelial Na + transport processes in human H441 lung epithelial cells (2006) (0)
A method for application of an on LKB1 / STRAD / MO25 complex (2004) (0)
Cell Metabolism Previews Metformin — ActingthroughCyclicAMPaswellasAMP ? (2013) (0)
Signal Transduction by Nuclear Receptors (1991) (0)
34P Oral Communication-Cellular Signalling C43 HYPOXIC PULMONARY VASOCONSTRICTION: IS AMP- ACTIVATED PROTEIN KINASE THE PRIMARY METABOLIC SENSOR AND EFFECTOR? (2005) (0)
Faculty Opinions recommendation of Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. (2008) (0)
Lipogenesis and acetyl-CoA carboxylase activity in lactating rat mammary gland: stimulation by spermine (1985) (0)
ISOLATION OF TWO CYCLIC AMP-INDEPENDENT PROTEIN KINASES WHICH PHOSPHORYLATE ACETYL-COA CARBOXYLASE (1981) (0)
Cancer Cell Previews The LKB 1-AMPK Pathway — Friend or Foe in Cancer ? (2013) (0)
Regulation of Cell Proliferation and Cancer (1991) (0)
Sensing of energy availability by the AMP-activated protein kinase (2009) (0)
Cell Biology of First Messenger Synthesis and Secretion (1991) (0)
Changes in mTOR/4‐EBP1 pathway induced by a novel mutation in PRKAG2 gene (864.7) (2014) (0)
Faculty Opinions recommendation of Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling. (2017) (0)
AMP-activated Protein Kinase Mediates Phenobarbital Induction of CYP 2 B Gene Expression in Hepatocytes and a Newly Derived Human (2005) (0)
STUDIES OF THE RESONANCE INTEGRALS OF Re AND Tm. Quarterly Progress Report, March 15, 1963 to June 30, 1963 (1963) (0)
The New Oxford History of Music (Vol. 5): Opera and Church Music 1630-1750 [Book Review] (1976) (0)
Metformin effects on breast cancer cell proliferation, AMPK pathway and the cell cycle (2012) (0)
Faculty Opinions recommendation of AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin. (2017) (0)
Regulation ofHMG-CoAreductase: identification ofthe sitephosphorylated bytheAMP-activated protein kinase invitro andinintact ratliver (1990) (0)
AMP-activated protein kinase: Regulating energy balance at both the cellular and whole body levels (2014) (0)
AICAR induces phosphorylation and deactivation of glycogen synthase in rat skeletal muscle (2002) (0)
Mechanism of action of metformin on insulin sensitization: Selective Fatty Acid Oxidation (FAO) over glucose oxidation via inhibition of complex I and activation of amp-activated protein kinase in C2C12 myocytes (2011) (0)
Neapolitan Comic Opera, 1707-1750: Some Addenda and Corrigenda for The New Grove (1983) (0)
Haydn Mozart and the Viennese School 1740-1780. by Daniel Heartz (1998) (0)
Studies in Music. No. 1, 1967@@@Miscellanea Musicologica. Adelaide Studies in Musicology. Vol. 2 (1968) (0)
STUDIES OF THE RESONANCE INTEGRALS OF Re AND Tm. Quarterly Progress Report, October 1, 1963-December 31, 1963 (1964) (0)
STUDIES OF THE RESONANCE INTEGRALS OF Re AND Tm. Final Report, March 15, 1963-March 14, 1964 (1964) (0)
Abstract 243: A Novel PRKAG2 Mutation (K475E): Infantile-onset Hypertrophic Cardiomyopathy Phenotype and Impact on mTOR Signaling (2016) (0)
AMP-activated protein kinase: regulating cellular and whole body energy balance (2010) (0)
The AMP-activated protein kinase system - protecting cellular and whole body energy balance (2007) (0)
[Proceedings: Immunochemistry of tobacco mosaic virus (TMV). Determination of association constants of Fab fragments]. (1975) (0)
AMP-activated protein kinase couples Kv1.5 channel function to inhibition of mitochondrial metabolism in pulmonary arterial myocytes (2016) (0)
A Novel PRKAG2 Mutation (K475E): Early‐Onset Cardiac Phenotype and Targeted Therapy (2018) (0)
Ched: Cholinesterase-related cell division controller (vertebrates) (1995) (0)
Faculty Opinions recommendation of TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. (2009) (0)
A transgenic mouse model to study a novel PRKAG2 mutation (K475E) causing infantile‐onset hypertrophic cardiomyopathy (2017) (0)
GLYCOGEN REGULATED AMP-ACTIVATED PROTEIN KINASE ACTIVITY AND ACETYLCOA CARBOXYLASE PHOSPHORYLATION DURING EXERCISE (2002) (0)
Evidence for Direct Cross‐talk between AMP‐activated kinase (AMPK) and O‐linked β‐N‐Acetylglucosaminyltransferase (OGT) (2011) (0)
The Rise of Romantic Opera [Book Review] (1977) (0)
Myokine responses to an acute bout of resistance exercise in rat (2009) (0)
AMPK - ARE ACTIVATORS OR INHIBITORS REQUIRED FOR CANCER TREATMENT? (2018) (0)
PROTECTING SKELETAL MUSCLE ATP DURING FATIGUE: HOW METABOLITES CONTRIBUTE TO CRISIS MANAGEMENT (2002) (0)
Glycogen depletion increases peroxisome proliferator activated receptor‐δ (PPAR‐δ) activity following acute exercise (2011) (0)
Molecular physiology. Ways of coping with stress. (1994) (0)
Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to calcium signaling in O2-sensing cells? VOLUME 280 (2005) PAGES 41504-41511 (2006) (0)
AMP-activated protein kinase — a journey from 1 to 100 downstream targets (2022) (0)
Functional characterization of MAP30 protein from bitter melon (Momordica charantia) in combating ovarian cancer oncogenesis and chemoresistance (2016) (0)
LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response (2022) (0)
Edinburgh Research Explorer Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet a (2011) (0)
Calmodulin-dependent multiprotein phosphorylate kinase and protein kinase C the same site on HMG-CoA reductase as the AMP-activated protein kinase (1990) (0)
Hardie AMPK in the cardiovascular system 1 1 AMP-ACTIVATED PROTEIN KINASE – A UBIQUITOUS SIGNALLING 2 PATHWAY WITH KEY ROLES IN THE CARDIOVASCULAR SYSTEM 3 4 (2017) (0)
Faculty Opinions recommendation of Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing. (2017) (0)
Running Title: AICAR stimulation of human glucose uptake (2007) (0)
AMP-activated protein kinase inhibits recombinant TASK-3 K+ channels (2010) (0)
Chapter 11 The AMP-activated/SNF1 protein kinases: Key players in the response of eukaryotic cells to metabolic stress (2001) (0)
Faculty Opinions recommendation of AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor. (2006) (0)
University of Dundee Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU 6656 and (2017) (0)
Faculty Opinions recommendation of Structural basis of AMPK regulation by adenine nucleotides and glycogen. (2017) (0)
Molecular Regulation of Energy Balance (2019) (0)
Energy-independent antagonism between insulin and AMP-activated protein kinase in the ischemic heart (2001) (0)
STUDIES OF THE SITE ON ATP-CITRATE LYASE PHOSPHORYLATED BY CYCLIC AMP-DEPENDENT PROTEIN KINASE (1981) (0)
The glycogen binding domain of the β-subunit of AMPK functions as a sensor of glycogen quality (2007) (0)
Title Bitter melon ( Momordica charantia ) extract functions as a natural AMPK activator and synergistically enhances cisplatin cytotoxicity in ovarian cancer cells (2016) (0)
Dual regulation of AMP-activated protein kinase and the control of creatine kinase in skeletal muscle. (1998) (0)
Publisher Correction: LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response (2022) (0)
AMP-activated protein kinase gamma-2 (AMPK-g2) subunit modulates AMPK activities to ensure ovarian cancer progression (2016) (0)
Faculty Opinions recommendation of Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. (2007) (0)
Edinburgh Research Explorer Selective Expression in Carotid Body Type I Cells of a Single Splice Variant of the Large Conductance Calcium- and Voltage-activated Potassium Channel Confers Regulation by AMP-activated Protein Kinase (2011) (0)
Edinburgh Research Explorer AMP-activated protein kinase and hypoxic pulmonary vasoconstriction. (2012) (0)
THE GREEN FLUORESCENT PROTEIN (2008) (0)
The AMPK activator A-769662 inhibits human TASK3 potassium channels in an AMPK-independent manner (2022) (0)
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress (2019) (0)
Twenty-five years of cyclic nucleotides (1982) (0)
Regulation of Kv1.5 by AMP-activated protein kinase in pulmonary arterial smooth muscle cells and recombinant channels (2014) (0)
Faculty Opinions recommendation of Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. (2009) (0)
AMPK in cancer: Tumor friend or foe? (2014) (0)
An Oncogenic Ro by Targeting AMP (0)
Ionic Homeostasis and Nervous Conduction (1991) (0)
Membrane Transport PC 1 Regulation of Na +-H + exchange in articular chondrocytes by O 2 (2006) (0)
AMP-Activated Protein Kinase Couples Mitochondrial Inhibition By Hypoxia to Calcium Signalling (2005) (0)
Expression of 11 (cid:1) -hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells (2005) (0)
Regulation of fatty acid synthesis and degradation by the AMP-activated protein kinase (2002) (0)

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