Gregg L. Semenza

Q: What Schools Are Affiliated With Gregg L. Semenza

Gregg L. Semenza is affiliated with the following schools: University of Oxford, University of Chicago, University System of Maryland, Johns Hopkins University, University of Zurich, Duke University, University of Pennsylvania, Harvard University

Gregg L. Semenza's AcademicInfluence.com Rankings

Gregg L. Semenza

Philosophy

#775

World Rank

#1502

Historical Rank

#344

USA Rank

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#85

World Rank

#227

Historical Rank

#37

USA Rank

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Philosophy

Gregg L. Semenza's Degrees

Doctorate Medicine University of Pennsylvania

Why Is Gregg L. Semenza Influential?

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According to Wikipedia, Gregg Leonard Semenza is a pediatrician and Professor of Genetic Medicine at the Johns Hopkins School of Medicine. He serves as the director of the vascular program at the Institute for Cell Engineering. He is a 2016 recipient of the Albert Lasker Award for Basic Medical Research. He is known for his discovery of HIF-1, which allows cancer cells to adapt to oxygen-poor environments. He shared the 2019 Nobel Prize in Physiology or Medicine for "discoveries of how cells sense and adapt to oxygen availability" with William Kaelin Jr. and Peter J. Ratcliffe. Semenza has had ten research papers retracted due to falsified data.

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Gregg L. Semenza's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

FEBS Lett (2000) (7931)
Targeting HIF-1 for cancer therapy (2003) (6118)
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. (1995) (5776)
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 (1996) (3799)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. (2006) (3173)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation (1992) (2564)
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. (1998) (2476)
Hypoxia-Inducible Factors in Physiology and Medicine (2012) (2409)
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. (1999) (2360)
Purification and Characterization of Hypoxia-inducible Factor 1 (*) (1995) (1995)
Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. (1999) (1932)
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. (1994) (1797)
HIF-1: mediator of physiological and pathophysiological responses to hypoxia. (2000) (1742)
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1* (1996) (1635)
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics (2010) (1583)
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia* (2008) (1498)
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. (2000) (1489)
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. (1993) (1423)
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. (2001) (1365)
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression (2001) (1286)
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. (2012) (1264)
HIF-1: upstream and downstream of cancer metabolism. (2010) (1193)
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. (1996) (1183)
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. (2000) (1179)
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression (2010) (1152)
Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1* (1996) (1112)
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1 (2011) (1109)
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 (2011) (1103)
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells (2007) (1102)
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. (2005) (1095)
Hypoxia-inducible factor 1: master regulator of O2 homeostasis. (1998) (1079)
A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of D-glucose and choline transport systems. (1978) (1064)
Oncogenic alterations of metabolism. (1999) (1034)
HIF-1 and mechanisms of hypoxia sensing. (2001) (1028)
HIF-1 and tumor progression: pathophysiology and therapeutics. (2002) (1017)
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. (2013) (1005)
Hypoxia and the extracellular matrix: drivers of tumour metastasis (2014) (1001)
HIF-1, O2, and the 3 PHDs How Animal Cells Signal Hypoxia to the Nucleus (2001) (918)
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. (2001) (917)
HIF-1 and human disease: one highly involved factor. (2000) (898)
Hydroxylation of HIF-1: oxygen sensing at the molecular level. (2004) (893)
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. (1993) (885)
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. (1991) (878)
Regulation of oxygen homeostasis by hypoxia-inducible factor 1. (2009) (871)
Oxygen sensing, homeostasis, and disease. (2011) (869)
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. (2014) (866)
Signal transduction to hypoxia-inducible factor 1. (2002) (864)
Hypoxia-Inducible Factor 1 (HIF-1) Pathway (2007) (846)
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. (2007) (819)
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells* (2002) (791)
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. (1993) (769)
Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia* (1997) (768)
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA (2016) (740)
Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011) (690)
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. (1999) (685)
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. (1999) (680)
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression (2000) (664)
Life with Oxygen (2007) (664)
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. (2003) (644)
Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α (1997) (632)
Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. (2001) (616)
Hypoxia-Inducible Factors: Master Regulators of Cancer Progression. (2016) (591)
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1 (2007) (575)
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. (1997) (574)
Hearts From Rodents Exposed to Intermittent Hypoxia or Erythropoietin Are Protected Against Ischemia‐Reperfusion Injury (2003) (569)
Cell Type–Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1 (2003) (568)
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth (2008) (568)
Expression of hypoxia‐inducible factor 1α in brain tumors (2000) (557)
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways (2005) (555)
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway* (2002) (543)
Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma (2003) (522)
Expression of hypoxia-inducible factor 1: mechanisms and consequences. (2000) (513)
Expression of angiogenesis‐related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis (2001) (503)
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. (2007) (503)
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia (2002) (488)
Levels of Hypoxia-Inducible Factor-1α During Breast Carcinogenesis (2001) (482)
Biologic correlates of 18fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography (2002) (479)
mechanisms of disease Oxygen Sensing , Homeostasis , and Disease (2011) (478)
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. (2012) (476)
HIF-dependent antitumorigenic effect of antioxidants in vivo. (2007) (466)
Regulation of angiogenesis by hypoxia-inducible factor 1. (2006) (452)
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. (2010) (448)
Hypoxia-inducible factor 1 and cardiovascular disease. (2014) (438)
Role of hypoxia‐inducible factor‐1 in hypoxia‐induced ischemic tolerance in neonatal rat brain (2000) (429)
Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. (1999) (424)
Regulation of cancer cell metabolism by hypoxia-inducible factor 1. (2009) (424)
In vivo expression of mRNAs encoding hypoxia-inducible factor 1. (1996) (421)
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization (2009) (420)
Induction of hypoxia‐inducible factor‐1 (HIF‐1) and its target genes following focal ischaemia in rat brain (1999) (419)
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. (2006) (418)
The hypoxic tumor microenvironment: A driving force for breast cancer progression. (2016) (406)
Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells (2014) (405)
Up‐regulation of gene expression by hypoxia is mediated predominantly by hypoxia‐inducible factor 1 (HIF‐1) (2005) (402)
Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. (2011) (399)
RACK1 Competes with HSP90 for Binding to HIF-1α and is Required for O2-independent and HSP90 Inhibitor-induced Degradation of HIF-1α (2007) (394)
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas (2005) (393)
Angiogenesis in ischemic and neoplastic disorders. (2003) (386)
Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression* (2001) (380)
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis (2014) (379)
Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts* (2013) (377)
Perspectives on Oxygen Sensing (1999) (375)
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation (2011) (362)
Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. (2000) (361)
Evaluation of HIF-1 inhibitors as anticancer agents. (2007) (361)
Anchoring and biosynthesis of stalked brush border membrane proteins: glycosidases and peptidases of enterocytes and renal tubuli. (1986) (360)
Heterozygous HIF‐1α deficiency impairs carotid body‐mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia (2006) (357)
Ultralarge atomically flat template-stripped Au surfaces for scanning probe microscopy (1993) (354)
Measuring elasticity of biological materials by atomic force microscopy (1998) (348)
Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression. (1999) (339)
Tumor metabolism: cancer cells give and take lactate. (2008) (337)
Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF (2009) (330)
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography. (2002) (327)
Hypoxia Inducible Factor 1 Mediates Hypoxia-Induced TRPC Expression and Elevated Intracellular Ca2+ in Pulmonary Arterial Smooth Muscle Cells (2006) (325)
HIF-1-dependent Expression of Angiopoietin-like 4 and L1CAM Mediates Vascular Metastasis of Hypoxic Breast Cancer Cells to the Lungs (2011) (323)
A genetic mechanism for Tibetan high-altitude adaptation (2014) (321)
Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21waf1/cip1, and Erythropoietin (1999) (318)
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. (1998) (312)
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. (2001) (311)
Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. (2000) (307)
Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling (2007) (304)
Regulation of metabolism by hypoxia-inducible factor 1. (2011) (299)
Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity* (2000) (298)
Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. (2000) (292)
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. (2003) (292)
Emerging roles of PKM2 in cell metabolism and cancer progression (2012) (291)
Induction of HIF‐1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR (2008) (290)
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α (2002) (289)
Oxygen sensing in the body. (2006) (287)
Effects of Aging and Hypoxia-Inducible Factor-1 Activity on Angiogenic Cell Mobilization and Recovery of Perfusion After Limb Ischemia (2007) (283)
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells (2009) (282)
Structural and functional analysis of hypoxia-inducible factor 1. (1997) (279)
HIF-1 mediates the Warburg effect in clear cell renal carcinoma (2007) (278)
O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. (2004) (272)
Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. (1998) (267)
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells (2015) (253)
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. (2007) (253)
HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. (2014) (253)
Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer. (1998) (253)
HIF-1: Using Two Hands to Flip the Angiogenic Switch (2004) (252)
The sucrase-isomaltase complex: Primary structure, membrane-orientation, and evolution of a stalked, intrinsic brush border protein (1986) (251)
Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. (2004) (250)
Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and Disease (2001) (249)
HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. (2011) (249)
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. (2008) (247)
Collagen prolyl hydroxylases are essential for breast cancer metastasis. (2013) (246)
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. (2013) (246)
Hypoxia, HIF-1, and the pathophysiology of common human diseases. (2000) (244)
Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex. (1991) (244)
Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype (2017) (237)
Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia* (2005) (237)
Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. (1995) (236)
Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer* (1998) (233)
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. (1991) (233)
Complete primary structure of human and rabbit lactase‐phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme. (1988) (231)
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. (2012) (228)
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice (2002) (227)
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. (2005) (227)
'The metabolism of tumours': 70 years later. (2001) (222)
Role of hypoxia-inducible factors in breast cancer metastasis. (2013) (219)
Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity (2008) (219)
Involvement of hypoxia-inducible factor 1 in human cancer. (2002) (219)
OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α (2005) (218)
Stromal Cell–Derived Factor-1α and CXCR4 Expression in Hemangioblastoma and Clear Cell-Renal Cell Carcinoma: von Hippel-Lindau Loss-of-Function Induces Expression of a Ligand and Its Receptor (2005) (214)
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis. (2009) (214)
Intratumoral hypoxia, radiation resistance, and HIF-1. (2004) (211)
Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling* (2004) (210)
Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. (2001) (208)
Phosphatidylinositol-3-Kinase Signaling Is Required for Erythropoietin-Mediated Acute Protection Against Myocardial Ischemia/Reperfusion Injury (2004) (207)
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. (2006) (204)
Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development* (2006) (204)
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α* (2009) (204)
Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis (2013) (202)
Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis. (1998) (201)
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression (2012) (200)
Hypoxia-Inducible Factor 1 Regulates Vascular Endothelial Growth Factor Expression in Human Pancreatic Cancer (2003) (196)
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis (2012) (196)
Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. (2004) (195)
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O 2 tension (2002) (192)
Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells (2016) (190)
Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells (2018) (189)
Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. (2012) (189)
Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis (2013) (188)
Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. (2006) (188)
Formation and in Situ Modification of Monolayers Chemisorbed on Ultraflat Template-Stripped Gold Surfaces (1995) (187)
Regulation of cell proliferation by hypoxia-inducible factors. (2015) (187)
The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation. (1998) (187)
Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells (2011) (186)
Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia (2011) (186)
Hydrophobic binding of the ectodomain of influenza hemagglutinin to membranes occurs through the "fusion peptide". (1989) (185)
Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia‐inducible factor 1 (2006) (184)
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis. (2016) (184)
Biochemistry of the Na+, D-glucose cotransporter of the small-intestinal brush-border membrane. The state of the art in 1984. (1984) (184)
Selective labeling of the hydrophobic core of membranes with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine, a carbene-generating reagent. (1981) (183)
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells (2012) (180)
Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1. (1995) (175)
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype (2015) (174)
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation* (2013) (173)
Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. (2003) (172)
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1* (2001) (171)
Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance. (2001) (170)
Oxygen-regulated transcription factors and their role in pulmonary disease (2000) (169)
Oxygen Sensing and Homeostasis. (2015) (167)
Age‐dependent impairment of HIF‐1α expression in diabetic mice: Correction with electroporation‐facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells (2008) (165)
ACQUIRED MILK INTOLERANCE IN THE ADULT CAUSED BY LACTOSE MALABSORPTION DUE TO A SELECTIVE DEFICIENCY OF INTESTINAL LACTASE ACTIVITY. (1965) (165)
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment (2014) (164)
ISOLATED INTESTINAL LACTASE DEFICIENCY IN THE ADULT. (1963) (164)
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer (2016) (163)
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells (2013) (163)
Negative regulation of hypoxic responses via induced Reptin methylation. (2010) (161)
Covalent immobilization of native biomolecules onto Au(111) via N-hydroxysuccinimide ester functionalized self-assembled monolayers for scanning probe microscopy. (1996) (160)
Hypoxia‐inducible factor 1 and cancer pathogenesis (2008) (160)
Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha. (2006) (157)
A physical sciences network characterization of non-tumorigenic and metastatic cells (2013) (157)
Pharmacologic Targeting of Hypoxia-Inducible Factors. (2019) (156)
Hypoxia-inducible factor 1 and breast cancer metastasis (2015) (156)
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart (2013) (155)
Up-regulation of Apoptosis Inhibitory Protein IAP-2 by Hypoxia (2001) (155)
Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. (1998) (153)
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1* (2006) (152)
Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. (2013) (151)
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization* (2007) (146)
LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. (2008) (146)
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. (1998) (146)
Transcriptional regulation by hypoxia-inducible factor 1 molecular mechanisms of oxygen homeostasis. (1996) (144)
Localization of cells producing erythropoietin in murine liver by in situ hybridization. (1991) (144)
Vascular responses to hypoxia and ischemia. (2010) (143)
Regulation of gene expression by HIF-1. (2006) (141)
Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin. (1995) (141)
ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. (2007) (136)
Polycythemia in transgenic mice expressing the human erythropoietin gene. (1989) (135)
Molecular basis of hypoxia‐induced erythropoietin expression (1996) (133)
Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia. (2005) (133)
HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia. (2007) (132)
Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis. (1994) (130)
Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements (1990) (129)
HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. (2010) (128)
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia (2009) (125)
Development of novel therapeutic strategies that target HIF-1 (2006) (124)
Transcriptional responses to intermittent hypoxia (2008) (124)
RACK1 vs. HSP90: Competition for HIF-1α Degradation vs. Stabilization (2007) (123)
HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart. (2005) (122)
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors* (2013) (121)
Oxygen homeostasis (2010) (121)
Respiratory Complications of Mucopolysaccharide Storage Disorders (1988) (121)
Erratum: Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (Journal of Clinical Investigation (2013) 123: 1 (189-205) DOI: 10.1172/JCI64993) (2013) (121)
Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis (2012) (120)
Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling (2012) (119)
Regulation of Cardiovascular Development and Physiology by Hypoxia‐Inducible Factor 1a (1999) (118)
Hypoxia-Inducible Factor 1α Polymorphism and Coronary Collaterals in Patients With Ischemic Heart Disease (2005) (118)
Hypoxia and cancer (2007) (114)
Molecular Events Implicated in Brain Tumor Angiogenesis and Invasion (2000) (113)
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4 (2013) (113)
Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A. (1996) (113)
Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice. (1997) (113)
The mode of association of the enzyme complex sucrase.isomaltase with the intestinal brush border membrane. (1979) (112)
HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery. (2009) (112)
Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer (2012) (112)
Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways (2009) (111)
Immobilizing DNA on gold via thiol modification for atomic force microscopy imaging in buffer solutions (1993) (111)
Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes. (2008) (111)
Human intestinal disaccharidases and hereditary disaccharide intolerance. The hydrolysis of sucrose, isomaltose, palatinose (isomaltulose), and a 1,6-alpha-oligosaccharide (isomalto-oligosaccharide) preparation. (1963) (110)
Activation of hypoxia-inducible factor 1 during macrophage differentiation. (2006) (110)
HIF-1α, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors (2002) (109)
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension (2011) (108)
On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase. (1973) (108)
Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors. (2018) (108)
Digoxin inhibits retinal ischemia‐induced HIF‐1α expression and ocular neovascularization (2010) (107)
Involvement of hypoxia-inducible factor 1 in pulmonary pathophysiology. (2005) (107)
Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. (2011) (107)
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. (2005) (107)
PTEN Activity Is Modulated During Ischemia and Reperfusion: Involvement in the Induction and Decay of Preconditioning (2005) (106)
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment. (2017) (106)
VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy (2013) (105)
Hypoxia Inducible Factor 1 Mediates Hypoxia-Induced TRPC Expression and Elevated Intracellular Ca 2 in Pulmonary Arterial Smooth Muscle Cells (2006) (105)
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype (2014) (105)
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. (2005) (104)
Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner (2008) (104)
The preparation of lactase and glucoamylase of rat small intestine. (1972) (103)
Studies on intestinal sucrace and on intestinal sugar transport. V. Isolaiton and properties of sucrase-isomaltase from rabbit small intestine☆☆☆ (1967) (102)
MULTIPLICITY OF HUMAN INTESTINAL DISACCHARIDASES. I. CHROMATOGRAPHIC SEPARATION OF MALTASES AND OF TWO LACTASES. (1965) (101)
Phlorizin as a probe of the small-intestinal Na+,D-glucose cotransporter. A model. (1982) (101)
Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization (2019) (99)
Localization of cells producing erythropoietin in murine liver by in situ hybridization (1991) (98)
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. (1998) (98)
Control of lactase in human adult-type hypolactasia and in weaning rabbits and rats. (1989) (96)
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer (2014) (96)
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication (2013) (95)
Evidence for H(+)-induced insertion of influenza hemagglutinin HA2 N-terminal segment into viral membrane. (1994) (95)
Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma (2016) (94)
DISACCHARIDASE ACTIVITIES IN HUMAN INTESTINAL MUCOSA. (1963) (94)
A fully active, two-active-site, single-chain sucrase.isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein. (1980) (93)
Biochemistry of Membrane Transport (1977) (92)
Digoxin inhibits development of hypoxic pulmonary hypertension in mice (2012) (91)
Selective Killing of Hypoxia-Inducible Factor-1–Active Cells Improves Survival in a Mouse Model of Invasive and Metastatic Pancreatic Cancer (2009) (91)
Regulation of intestinal lactase in adult hypolactasia. (1992) (90)
Protein kinase G–regulated production of H2S governs oxygen sensing (2015) (90)
The human lactase‐phlorizin hydrolase gene is located on chromosome 2 (1988) (89)
Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery. (2011) (89)
RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. (2007) (89)
Oxygen Sensing : Responses and Adaption to Hypoxia (2003) (88)
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment (2018) (88)
A hydrophobic form of the small-intestinal sucrase-isomaltase complex. (1975) (88)
Human Cancers and Their Metastases in Common α Overexpression of Hypoxia-inducible Factor 1 Updated Version (1999) (87)
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice (2009) (87)
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning (2012) (87)
Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis (2013) (87)
Hypoxia-inducible factor 1: from molecular biology to cardiopulmonary physiology. (1998) (86)
Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. (1998) (85)
Cellular and molecular dissection of reperfusion injury: ROS within and without. (2000) (84)
A spectroscopic technique for measuring slow rotational diffusion of macromolecules. 1: Preparation and properties of a triplet probe. (1976) (84)
Biosynthesis of sucrase-isomaltase. Purification and NH2-terminal amino acid sequence of the rat sucrase-isomaltase precursor (pro-sucrase-isomaltase) from fetal intestinal transplants. (1982) (84)
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy (2015) (84)
An example of enzyme hysteresis. The slow and tight interaction of some fully competitive inhibitors with small intestinal sucrase. (1981) (84)
MCM proteins are negative regulators of hypoxia-inducible factor 1. (2011) (81)
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression (2014) (80)
The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regions (1984) (79)
Regulation of hypoxia‐inducible factor‐α isoforms and redox state by carotid body neural activity in rats (2014) (79)
Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q. (1996) (77)
Multiplicity of carriers for free glucalogues in hamster small intestine (1973) (77)
Na+-dependent, electroneutral L-ascorbate transport across brush border membrane vesicles from guinea pig small intestine. (1979) (77)
Maintenance of redox homeostasis by hypoxia-inducible factors (2017) (75)
Gaseous messengers in oxygen sensing (2012) (75)
HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase (2015) (74)
The hydrophobic anchor of small‐intestinal sucrase—isomaltase (1978) (74)
Atomic force microscopy detects changes in the interaction forces between GroEL and substrate proteins. (1998) (74)
A simplified procedure for the isolation of the sucrase-isomaltase complex from rabbit intestine. Its amino-acid and sugar composition. (1972) (74)
Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis (2017) (74)
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration (2018) (74)
A compendium of proteins that interact with HIF-1α. (2017) (73)
Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1. (2013) (73)
Single bilayer lipid-protein vesicles formed from phosphatidylcholine and small intestinal sucrase.isomaltase. (1978) (73)
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation (2008) (73)
Mitochondrial autophagy: Life and breath of the cell (2008) (73)
Differentiation Stage-Specific Requirement in Hypoxia-Inducible Factor-1α–Regulated Glycolytic Pathway during Murine B Cell Development in Bone Marrow (2009) (71)
Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1 (2016) (70)
KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi’s sarcoma (2015) (70)
Reconstitution of a sucrase‐mediated sugar transport system in lipid membranes (1972) (69)
Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring. (1990) (69)
Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF‐1α heterozygous‐null mice after burn wounding (2010) (69)
Partial amino acid sequences around the essential carboxylate in the active sites of the intestinal sucrase-isomaltase complex. (1976) (68)
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α* (2007) (67)
MULTIPLICITY OF HUMAN INTESTINAL DISACCHARIDASES. II. CHARACTERIZATION OF THE INDIVIDUAL MALTASES. (1965) (67)
Matrix Rigidity Controls Endothelial Differentiation and Morphogenesis of Cardiac Precursors (2012) (66)
Hydrophobic photolabeling identifies BHA2 as the subunit mediating the interaction of bromelain-solubilized influenza virus hemagglutinin with liposomes at low pH. (1988) (66)
Steady‐State Kinetics of Rabbit‐Intestinal Sucrase (1974) (66)
Oxygen-independent upregulation of vascular endothelial growth factor and vascular barrier dysfunction during ventilated pulmonary ischemia in isolated ferret lungs. (2000) (65)
Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. (2011) (65)
A probable oxocarbonium ion in the reaction mechanism of small intestinal sucrase and isomaltase. (1975) (65)
Lactase persistence versus decline in human adults: multifactorial events are involved in down-regulation after weaning. (1997) (64)
Molecular cytogenetic characterization of a subtle interstitial del(3)(p25.3p26.2) in a patient with deletion 3p syndrome. (2002) (64)
T-cell activation under hypoxic conditions enhances IFN-gamma secretion. (2010) (64)
Location of the two catalytic sites in intestinal lactase-phlorizin hydrolase. Comparison with sucrase-isomaltase and with other glycosidases, the membrane anchor of lactase-phlorizin hydrolase. (1992) (64)
Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors. (2016) (63)
Analysis of hypoxia-induced metabolic reprogramming. (2014) (63)
Hypoxia-inducible factors enhance glutamate signaling in cancer cells (2014) (61)
Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment. (2018) (61)
Identification of chemical compounds that induce HIF-1alpha activity. (2009) (60)
High-affinity phlorizin binding to brush border membranes from small intestine: identity with (a part of) the glucose transport system, dependence on Na +-gradient, partial purification. (1977) (60)
Regulation of Vascularization by Hypoxia‐Inducible Factor 1 (2009) (60)
Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea. (2015) (60)
Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling* (2004) (59)
Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. (2011) (59)
Subunits of the small-intestinal sucrase-isomaltase complex and separation of its enzymatically active isomaltase moiety. (1973) (58)
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α* (2007) (58)
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors. (2002) (58)
Intestinal lactase‐phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro‐LPH maturation (1998) (58)
Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue. (2011) (57)
SOLUBILIZATION OF THE HUMAN INTESTINAL DISACCHARIDASES. (1963) (57)
Transmembrane disposition of the phlorizin binding protein of intestinal brush borders (1979) (57)
HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells (2015) (56)
Transcriptional regulation of gene expression: Mechanisms and pathophysiology (1994) (55)
Interaction of the sugar carrier of intestinal brush-border membranes with HgCl2. (1980) (55)
Membrane biochemistry : a laboratory manual on transport and bioenergetics (1979) (55)
Small Molecule Activation of Adaptive Gene Expression (2008) (54)
Sustained delivery of a HIF-1 antagonist for ocular neovascularization. (2013) (54)
Enhanced Bone Regeneration Associated With Decreased Apoptosis in Mice With Partial HIF‐1α Deficiency (2007) (53)
Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization (2015) (52)
Expression of Hypoxia-inducible Factor-1 a : A Novel Predictive and Prognostic Parameter in the Radiotherapy of Oropharyngeal Cancer 1 (2001) (51)
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. (2020) (51)
Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1. (2005) (51)
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin (2011) (50)
Short-chain phosphatidylcholines as superior detergents in solubilizing membrane proteins and preserving biological activity. (1994) (50)
Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis (2014) (50)
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation. (2008) (49)
Na+-dependent, potential-sensitive L-ascorbate transport across brush border membrane vesicles from kidney cortex. (1981) (49)
Epigenetic changes by DNA methylation in chronic and intermittent hypoxia. (2017) (49)
Partial rescue of defects in Cited2-deficient embryos by HIF-1α heterozygosity (2007) (48)
Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds (2011) (48)
Affinity labeling of the active sites in the sucrase-isomaltase complex from small intestine. (1974) (48)
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1* (2012) (48)
Regulation of tissue perfusion in mammals by hypoxia‐inducible factor 1 (2007) (48)
p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. (1997) (47)
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension (2019) (47)
Complementary roles of gasotransmitters CO and H2S in sleep apnea (2017) (47)
Advances in Brief Modulation of Hypoxia-inducible Factor 1 a Expression by the Epidermal Growth Factor / Phosphatidylinositol 3-Kinase / PTEN / AKT / FRAP Pathway in Human Prostate Cancer Cells : Implications for Tumor Angiogenesis and Therapeutics 1 (2000) (47)
Covalent anchoring of proteins onto gold‐directed NHS‐terminated self‐assembled monolayers in aqueous buffers: SFM images of clathrin cages and triskelia (1994) (47)
Isolation of (a subunit of) the Na+/D‐glucose contransporter(s) of rabbit intestinal brush border membranes using monoclonal antibodies (1983) (47)
Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long‐term intermittent hypoxia (2017) (47)
On the mechanism of mutual inhibition among sodium-dependent transport systems in the small intestine. A hypothesis. (1971) (46)
The electrogenic, Na+-dependent I- transport system in plasma membrane vesicles from thyroid glands. (1987) (46)
Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. (2013) (46)
Photoaffinity labeling and identification of (a component of) the small‐intestinal Na+, D‐glucose transporter using 4‐azidophlorizin (1981) (46)
Association of increasing burn severity in mice with delayed mobilization of circulating angiogenic cells. (2010) (46)
Small Intestinal Disaccharidases: Their Properties and Role as Sugar Translocators across Natural and Artificial Membranes (1976) (45)
Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles. (2014) (45)
A new weapon for attacking tumor blood vessels. (2008) (45)
Distribution of sulfhydryl groups in intestinal brush border membranes. Localization of side-chains essential for glucose transport and phlorizin binding. (1979) (45)
The sodium activation of biotin absorption in hamster small intestine in vitro. (1972) (45)
The role of hypoxia‐inducible factors in carotid body (patho) physiology (2018) (44)
Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy. (2019) (44)
Hydrophobic labeling, isolation, and partial characterization of the NH2-terminal membranous segment of sucrase-isomaltase complex. (1982) (44)
Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer (2014) (43)
Altered hypoxia‐inducible factor‐1 alpha expression levels correlate with coronary vessel anomalies (2009) (42)
SUCROSE-ISOMALTOSE MALABSORPTION IN AN ADULT WOMAN. (1964) (42)
Disaccharidases of Small‐Intestinal Mucosa (1985) (42)
The expression of lactase enzymatic activity and mRNA in human fetal jejunum Effect of organ culture and of treatment with hydrocortisone (1992) (42)
Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs. (2015) (42)
Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors. (2015) (41)
Small intestinal phlorizin hydrolase: The “β-glycosidase complex” (1973) (41)
Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox. (2016) (41)
Messenger RNAs expressed in intestine of adult but not baby rabbits. Isolation of cognate cDNAs and characterization of a novel brush border protein with esterase and phospholipase activity. (1993) (40)
Enhanced Interferon-γ Gene Expression in T Cells and Reduced Ovalbumin-Dependent Lung Eosinophilia in Hypoxia-Inducible Factor-1-α-Deficient Mice (2009) (40)
The intravenous anesthetic propofol inhibits hypoxia‐inducible factor 1 activity in an oxygen tension‐dependent manner (2004) (40)
Regulation of carotid body oxygen sensing by hypoxia-inducible factors (2015) (40)
The Genomics and Genetics of Oxygen Homeostasis. (2020) (40)
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP (2002) (40)
Systems biology of oxygen homeostasis (2017) (40)
Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. (2007) (40)
SODIUM ACTIVATION OF HUMAN INTESTINAL SUCRASE AND ITS POSSIBLE SIGNIFICANCE IN THE ENZYME ORGANIZATION OF BRUSH BORDERS. (1964) (40)
The biosynthesis of intestinal sucrase-isomaltase in human embryo is most likely controlled at the level of transcription. (1987) (40)
Chromatographic separation of human intestinal disaccharidases. (1962) (40)
Localization of rabbit intestinal sucrase with ferritin-antibody conjugates. (1970) (39)
Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease. (2005) (38)
Studies on intestinal sucrase and sugar transport. VII. A method for measuring intestinal uptake. The absorption of the anomeric forms of some monosaccharides. (1969) (38)
Advantages and limitations of vesicles for the characterization and the kinetic analysis of transport systems. (1990) (38)
The small-intestinal Na+,d-glucose cotransporter: An asymmetric gated channel (or pore) responsive to ΔΨ (2005) (38)
Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity. (2007) (38)
cDNA cloning and expression in Xenopus laevis oocytes of pig renal dipeptidase, a glycosyl-phosphatidylinositol-anchored ectoenzyme. (1990) (38)
Cell‐free synthesis of the one‐chain precursor of a major intrinsic protein complex of the small‐intestinal brush border membrane (pro‐sucrase—isomaltase) (1981) (37)
Hydrophobic labeling of a single leaflet of the human erythrocyte membrane. (1983) (37)
Reversible inhibition of hypoxia‐inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane (2001) (37)
Glycophorin-enriched vesicles obtained by a selective extraction of human erythrocyte membranes with a non-ionic detergent. (1979) (36)
Membrane protein topology: amino acid residues in a putative transmembrane .alpha.-helix of bacteriorhodopsin labeled with the hydrophobic carbene-generating reagent 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine (1985) (36)
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. (2004) (36)
Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. (2014) (36)
Familial polycythemia [4] (1995) (35)
Increased Expression of Hypoxia Iriducible Factor-1a in Rat and Human Prostate Cancer1 (1998) (35)
Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award. (2016) (35)
HIF-1α is required for development of the sympathetic nervous system (2019) (35)
Detection of a novel DNA polymorphism in the beta-globin gene cluster. (1984) (34)
HIF-1beta determines ABCA1 expression under hypoxia in human macrophages. (2010) (34)
Orientation and motion of spin-labels in rabbit small intestinal brush border vesicle membranes. (1982) (33)
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
Oxygen sensing and response to hypoxia by mammalian cells. (1996) (33)
The role of hypoxia-inducible factors in oxygen sensing by the carotid body. (2012) (33)
The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway. (2004) (32)
Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells. (2007) (32)
Common food intolerances 2 : milk in human nutrition and adult-type hypolactasia (1993) (32)
Analysis of hypoxia-inducible factor 1alpha expression and its effects on invasion and metastasis. (2007) (32)
DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2. (1995) (32)
Graft microvascular disease in solid organ transplantation (2014) (32)
Hypoxia-Inducible Factor 1&agr; Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELM&agr;)–Induced Pulmonary Hypertension (2016) (32)
H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea (2016) (32)
A Second Enzyme Defect in Acquired Lactase Deficiency: Lack of Small‐Intestinal Phlorizin‐Hydrolase (1972) (32)
Transcription Factors and Human Disease (1998) (32)
PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia (2016) (31)
The levels of lactase and of sucrase‐isomaltase along the rabbit small intestine are regulated both at the mRNA level and post‐translationally (1992) (31)
Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization (2017) (31)
Sequence of the precursor of intestinal lactase-phlorizin hydrolase from fetal rat. (1991) (30)
The biguanide inhibition of D-glucose transport in membrane vesicles from small intestine brush borders. (1975) (30)
Chromatographic purification of cysteinyl-glycinase. (1957) (30)
The pro sequence of lactase‐phlorizin hydrolase is required for the enzyme to reach the plasma membrane (1993) (30)
Introduction to tumor microenvironment regulation of cancer cell survival, metastasis, inflammation, and immune surveillance. (2016) (29)
4-Azidophlorizin, a high affinity probe and photoaffinity label for the glucose transporter in brush border membranes. (1982) (29)
Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells. (2012) (29)
On the primary site of control in the spontaneous development of small‐intestinal sucrase‐isomaltase after birth (1986) (29)
Maturation of human lactase‐phlorizin hydrolase Proteolytic cleavage of precursor occurs after passage through the Golgi complex (1992) (28)
Combination of HIF-1α gene transfection and HIF-1-activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice (2013) (28)
Preparation of basal cell membranes for scanning probe microscopy (1998) (28)
Lack of some intestinal maltases in a human disease transmitted by a single genetic factor. (1965) (28)
The configurations at the anomeric carbon of the reaction products of some digestive carbohydrases (1969) (28)
PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility (2014) (28)
The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions. (1984) (27)
VHL and p53: tumor suppressors team up to prevent cancer. (2006) (27)
Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway (2017) (27)
Single amino acid substitutions can convert the uncleaved signal-anchor of sucrase-isomaltase to a cleaved signal sequence. (1992) (27)
Dissociation of small-intestinal sucrase - isomaltase complex into enzymatically active subunits. (1975) (27)
Advances in Brief Reciprocal Positive Regulation of Hypoxia-inducible Factor 1 a and Insulin-like Growth Factor 21 (1999) (27)
Stereospecific ring opening of conduritol-B-epoxide by an active site asparatate residue of sucrase-isomaltase. (1977) (26)
Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus (2013) (26)
New insights into nNOS regulation of vascular homeostasis. (2005) (25)
On the efficiency of energy conversion in sodium‐driven D‐glucose transport across small intestinal brush border membrane vesicles: an estimation (1979) (25)
Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis (2021) (25)
Hypoxia Inducible Factor 1 Mediates Hypoxia-Induced TRPC Expression and Elevated Intracellular Ca 2 (cid:1) in Pulmonary Arterial Smooth Muscle Cells (2006) (24)
Rapid transmembrane movement of phosphatidylcholine in small unilamellar lipid vesicles formed by detergent removal. (1981) (24)
Hydrodynamic properties of the sucrase-isomaltase complex from rabbit small intestine. (1973) (24)
Similarity in effects of Na+ gradients and membrane potentials ond-glucose transport by, and phlorizin binding to, vesicles derived from brush borders of rabbit intestinal mucosal cells (1978) (24)
Meeting report: exploiting the tumor microenvironment for therapeutics. (2006) (24)
Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors. (2021) (24)
Studies on intestinal sucrase and intestinal sugar transport. VI. Liberation of alpha-glucose by sucrase and isomaltase from the glycone moiety of the substrates. (1967) (24)
Ion and sugar permeabilities of lecithin bilayers: Comparison of curved and planar bilayers (1980) (24)
Hinf I polymorphism 3' to the human beta-globin gene detected by the polymerase chain reaction (PCR). (1989) (24)
Membrane topology of light-harvesting protein B870-alpha of Rhodospirillum rubrum G-9+. Amino acid residues in contact with the lipid bilayer as inferred from labeling with photogenerated carbenes. (1985) (24)
Chemical modification of the small intestinal Na+/D-glucose cotransporter by amino group reagents. Evidence for a role of amino group(s) in the binding of the sugar. (1983) (23)
An essential role for chaperone-mediated autophagy in cell cycle progression (2015) (23)
Endothelial Hypoxia-Inducible Factor-2&agr; Is Required for the Maintenance of Airway Microvasculature (2019) (23)
N‐terminal sequences of pig intestinal sucrase—isomaltase and pro‐sucrase—isomaltase (1982) (23)
Modified DNA immobilized on bioreactive self‐assembled monolayer on gold for dynamic force microscopy imaging in aqueous buffer solution (1996) (22)
The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver (1993) (22)
The mode of anchoring and precursor forms of sucrase-isomaltase and maltase-glucoamylase in chicken intestinal brush-border membrane. Phylogenetic implications. (1987) (22)
β-Galactosidase activity in human intestinal lactases (1966) (22)
Incorporation of hydrophobic aminopeptidase from hog kidney into egg lecithin liposomes: Number and orientation of aminopeptidase molecules in the lecithin vesicles (1976) (22)
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment. (2021) (22)
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization (2021) (22)
Hypoxia-inducible factors: cancer progression and clinical translation (2022) (22)
Hypoxia and human disease—and the Journal of Molecular Medicine (2007) (22)
ω‐functionalized self‐assembled monolayers chemisorbed on ultraflat Au(111) surfaces for biological scanning probe microscopy in aqueous buffers (1996) (22)
Specific photoaffinity inactivation of the D-glucose transporter in small intestinal brush border membrane using new phlorizin analogues. (1981) (21)
Tryptic digestion of native small-intestinal sucrase - isomaltase complex: isolation of the sucrase subunit. (1975) (21)
O2 Sensing: Only Skin Deep? (2008) (21)
Hydrodynamic properties of phospholipid vesicles and of sucrase isomaltase-phospholipid vesicles. (1981) (21)
Sucrase-isomaltase: a stalked intrinsic protein of the brush border membrane. (1983) (21)
Membrane transport driven by ion gradients. (1985) (21)
Familial polycythemia. (1995) (20)
Studies on intestinal sucrase and on intestinal sugar transport. V. Isolation and properties of sucrase-isomaltase from rabbit small intestine. (1967) (20)
Therapeutic angiogenesis: another passing phase? (2006) (20)
Phospholipid topology and flip-flop in intestinal brush-border membrane. (1986) (20)
Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy (2017) (20)
Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1α and HIF-2α (2010) (19)
Immunochemical study of isolated human and rabbit intestinal sucrase. (1968) (19)
A two-active site one-polypeptide enzyme: the isomaltase from sea lion small intestinal brush-border membrane. Its possible phylogenetic relationship with sucrase-isomaltase. (1984) (19)
BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. (2020) (19)
Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema. (2020) (19)
Ethanol selectively affects Na+‐gradient dependent intestinal transport systems (1986) (19)
Chairman's summary: mechanisms of oxygen homeostasis, circa 1999. (2000) (19)
AFM structural study of the molecular chaperone GroEL and its two-dimensional crystals: an ideal "living" calibration sample. (2002) (19)
Oxygen Sensing in Health and Disease O 2-regulated gene expression : transcriptional control of cardiorespiratory physiology by HIF-1 (2004) (19)
Cell-free synthesis, membrane integration, and glycosylation of pro-sucrase-isomaltase. (1986) (19)
Small-intestinal Na+/D-glucose cotransport. Inactivation of sugar transport and phlorizin binding by thiol-group and amino-group reagents. (1983) (19)
Expression Pattern of HIF-1α and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy (2016) (19)
Vascular Endothelial Growth Factor Gene Expression in Colon Cancer Cells Exposed to Prostaglandin E 2 Is Mediated by Hypoxia-inducible Factor 1 1 (2003) (18)
HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy (2022) (18)
G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth. (2010) (18)
An example of mutual competition between transport inhibitors of different kinetic type: the inhibition of intestinal transport of glucalogues by phloretin and phlorizin. (1972) (18)
The expanding universe of hypoxia (2008) (18)
The Small‐Intestinal Sodium‐Glucose Cotransporter(s) a (1985) (17)
Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells (2011) (17)
Carboxyl groups at the two active centers of sucrase-isomaltase from rabbit small intestine. (1977) (17)
Selected topics in the history of biochemistry (1983) (17)
Erythropoietin ontogeny and organ distribution in mice. (1991) (16)
Imaging the native structure of the chaperone protein GroEL without fixation using atomic force microscopy (2001) (16)
n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems. (2008) (16)
A return to cancer metabolism (2011) (16)
HIF-1–regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/β-catenin pathway activation (2021) (16)
Reducing bias: accounting for the order of co-first authors. (2019) (15)
Of oxygen, fuels, and living matter (1981) (15)
Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1 (2021) (15)
A kinetic investigation on the allosteric effects in intestinal sucrase. (1969) (14)
HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells. (2021) (14)
[INTESTINAL ABSORPTION AND MALABSORPTION OF DISACCHARIDES]. (1963) (14)
Processing of Human Intestinal Prolactase to an Intermediate Form by Furin or by a Furin-like Proprotein Convertase* (1998) (14)
Biosynthesis and assembly of the largest and major intrinsic polypeptide of the small intestinal brush borders. (1983) (13)
Arbutin absorption in human small intestine: a simple procedure for the determination of active sugar uptake in peroral biopsy specimens. (1969) (13)
Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae). (2018) (13)
Furin, PC1/3, and/or PC6A Process Rabbit, but Not Human, Pro-lactase-phlorizin Hydrolase to the 180-kDa Intermediate (*) (1995) (13)
Hypoxia‐Inducible Factor 1 Mediates Increased Expression of NADPH Oxidase‐2 in Response to Intermittent Hypoxia (2011) (13)
Multiple Roles of Neurotransmitters in the Carotid Body: Involvement in Sensory Transmission and Adaptation to Hypoxia (2003) (13)
Na+‐dependent, electroneutral L‐ascorbate transport across brush border membrane vesicles from human small intestine (1979) (12)
Allosteric effects and phlorizin inhibition of intestinal trehalase. (1969) (12)
Segregation of a familial balanced (12;10) insertion resulting in Dup(10)(q21.2q22.1) and Del(10)(q21.2q22.1) in first cousins. (1997) (12)
Small intestinal phlorizin hydrolase: the "beta-glycosidase complex". (1973) (12)
DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity (2018) (12)
Decreased lymphatic HIF-2α accentuates lymphatic remodeling in lymphedema. (2020) (11)
Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia (2017) (11)
Microstructured bioreactive surfaces: covalent immobilization of proteins on Au(1 1 1)/silicon via aminoreactive alkanethiolate self-assembled monolayers (1999) (11)
Rate equations of some cases of enzyme inhibition and activation--their application to sodium-activated membrane transport systems. (1967) (11)
HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease. (2021) (11)
HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia (2022) (11)
Hypoxia inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia. (2020) (11)
G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth. (2010) (11)
Region‐specific expression of multiple lactase‐phlorizin hydrolase genes in intestine of rabbit (1993) (10)
Molecular pathophysiology of small-intestinal sucrase--isomaltase. (1981) (10)
Does Loss of CD151 Expression Promote the Metastasis of Hypoxic Colon Cancer Cells? (2008) (10)
Stromal Cell – Derived Factor-1 A and CXCR 4 Expression in Hemangioblastoma and Clear Cell-Renal Cell Carcinoma : von Hippel-Lindau Loss-of-Function Induces Expression of a Ligand and Its Receptor (2005) (10)
Transient opening of brush border membrane vesicles in alkaline media (1979) (10)
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1&agr; Degradation (2017) (10)
THE MODE OF ANCHORING OF SUCRASE-ISOMALTASE TO THE SMALL INTESTINAL BRUSH-BORDER MEMBRANE AND ITS BIOSYNTHETIC IMPLICATIONS (1979) (10)
Steady-state kinetics of rabbit-intestinal sucrase. Kinetic mechanism, Na+ activation, inhibition by tris(hydroxymethyl)aminomethane at the glucose subsite. (1974) (10)
Small intestinal sucrase and isomaltase split the bond between glucosyl-C1 and the glycosyl oxygen. (1975) (10)
[Chromatography of polyelectrolytes. VI. Protein chromatography on ion exchange cellulose derivatives]. (1960) (10)
Digestion and absorption of sugars. (1968) (9)
Functional analysis of the role of hypoxia-inducible factor 1 in the pathogenesis of hypoxic pulmonary hypertension. (2004) (9)
THE SMALL‐INTESTINAL SODIUM, d‐GLUCOSE COTRANSPORTER IS INSERTED IN THE BRUSH BORDER MEMBRANE ASYMMETRICALLY * (1980) (9)
Protein binding of rifampicin to bovine serum albumin as measured by gel filtration. (1977) (9)
The J.E. Purkynĕ lecture: the insertion of stalked proteins of the brush border membranes: the state of the art in 1988. (1989) (9)
Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations. (2022) (9)
Series introduction: tissue ischemia: pathophysiology and therapeutics (2000) (9)
HIF-dependent Anti-tumorigenic Effect of Anti-oxidants In Vivo (2007) (8)
An Xba I polymorphism 3' to the human erythropoietin (EPO) gene. (1987) (8)
"Adult only" esterase/phospholipase A of the small-intestine brush border membrane: isolation, identification of the catalytic site, and biosynthesis. (1997) (8)
Sucrase--isomaltase of the small-intestinal brush border membrane: assembly and biosynthesis. (1983) (8)
Mode of insertion of the sucrase-isomaltase complex in the intestinal brush border membrane: implications for the biosynthesis of this stalked intrinsic membrane protein. (1979) (8)
DETECTION OF A NOVEL DNA POLYMORPHISM IN THE β-GLOBIN CLUSTER AND EVIDENCE FOR SITE-SPECIFIC RECOMBINATION (1984) (8)
Baffled by Bafilomycin: An Anticancer Agent That Induces Hypoxia-Inducible Factor-1α Expression (2006) (8)
AN APPROACH TO THE ION EXCHANGE CHROMATOGRAPHY OF POLYELECTROLYTES. II. EXPERIMENTAL EVALUATION OF THE MODEL. (1965) (8)
Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic. (2020) (8)
Gas biology: small molecular medicine (2012) (8)
Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors (Science Signaling (2012) 5) (2012) (7)
Heat-acclimation-ischemia cross-tolerance: Does HIF-1α play a role? (2001) (7)
[16]Identification and characterization of transcription factors from mammalian cells (1996) (7)
A chemical procedure for determining the sidedness of the NH2 terminus in a membrane protein. The small intestinal sucrase-isomaltase. (1983) (7)
A Hypothesis on the Mechanism of Mutual Inhibition among Sodium-Dependent Transport Systems in the Small Intestine (1972) (6)
Phosphorylation of the N-terminal intracellular tail of sucrase-isomaltase by cAMP-dependent protein kinase. (1995) (6)
The Small-Intestinal Na+/D-Glucose Carrier Is Inserted Asymmetrically with Respect to the Plane of the Brush Border Membrane (1982) (6)
Critical carboxyl group(s) in Na+-dependent cotransporters of the intestinal brush-border membrane. (1987) (6)
Hypoxia pathway linked to kidney failure (2006) (6)
Intestinal digestion and absorption of sugars. (1975) (5)
Effects of Aging and Hypoxia-Inducible Factor-1 Activity on Angiogenic Cell Mobilization and Recovery of Perfusion Following Limb Ischemia (2007) (5)
Incorporation of Pure Hydrolases Isolated from Brush Border Membranes in Single-Bilayer Lecithin Vesicles (1977) (5)
For their discoveries of how cells sense and adapt to oxygen availability (2019) (5)
What is hypoxia‐inducible factor‐1 doing in the allergic lung? (2011) (5)
In Vitro Assays of Breast Cancer Stem Cells. (2018) (5)
AN APPROACH TO THE ION EXCHANGE CHROMATOGRAPHY OF POLYELECTROLYTES. I. A MODEL BASED ON THE LAW OF MASS ACTION. (1965) (5)
DNA: the double helix. (2003) (5)
American Journal of Physiology-Cell Physiology theme: hypoxia. (2011) (5)
A Possible Common Activation Site in Na+-Driven Transport Systems. Partial Purification of the Na-Dependent D-Glucose Transport System From Small Intestinal Brush Borders (1977) (5)
Anchoring and Biosynthesis of a Major Intrinsic Plasma Membrane Protein:The Sucrase—Isomaltase Complex of the Small-Intestinal Brush Border (1985) (4)
The melanotropins: Chemistry, physiology and mechanisms of action : By A.N. Eberle S. Karger; Basel, 1988 xx + 556 pages. £145.00, SFr.319.00, DM 382.00, $212.75 (1989) (4)
Hypoxia and Hypoxia-Inducible Factors in Lymphedema (2022) (4)
Abstract 3937: Collagen prolyl hydroxylases are essential for breast cancer metastasis. (2013) (4)
Erythropoietin Gene Expression in Transgenic Mice and Human Hepatoma Cells a (1994) (4)
Regulation of Gene Transcription by Hypoxia-Inducible Factor 1 (2013) (4)
Shifting paradigms for ischaemic preconditioning (2012) (4)
HUMAN INTESTINAL DISACCHARIDASESAND HEREDITARY DISACCHARIDE INTOLERANCE . THE HYDROLYSIS OF SUCROSE , ISOMALTOSE , PALATINOSE ( ISOMALTU-LOSE ) , AND A 1 , 6-a-OLIGOSACCHARIDE ( ISO-MALTO-OLIGOSACCHARIDE ) PREPARATION (4)
Breakthrough Science: Hypoxia-Inducible Factors, Oxygen Sensing, and Disorders of Hematopoiesis. (2021) (4)
Control of oxygen homeostasis by hypoxia-inducible factor 1: Essential roles in embryogenesis, physiology, and disease pathogenesis (2001) (4)
Separation of Purines and Pyrimidines by Paper Electrophoresis. (1957) (4)
Partial purification of the sugar carrier of intestinal brush border membranes. Enrichment of the phlorizin-binding component by selective extractions (1979) (4)
Solubilization, reconstitution, and attempted affinity chromatography of the sugar transporter of the erythrocyte membrane (1985) (4)
Advances in cancer biology and therapy (2013) (4)
Disposition of the car☐y‐terminus tail of rabbit lactase‐phlorizin hydrolase elucidated by phosphorylation with protein kinase A in vitro and in tissue culture (1995) (4)
LYMPHOSARCOMA IN A ST. LOUIS GIRL CLINICALLY AND HISTIOLOGICALLY RESEMBLING BURKITT'S AFRICAN LYMPHOMA. (1965) (3)
Hypoxia and Breast Cancer Metastasis (2014) (3)
A brush-border-bound peptidase and amino acid transport. (1977) (3)
Species differences in the sites of cleavage of pro-lactase to lactase supports lack of selective pressure. (1999) (3)
Abstract 5453: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression (2010) (3)
The minimum catalytic mechanism of intestinal sucrase and isomaltase. (1991) (3)
January 31st 1933 and the clarificaton of urea biosynthesis (2003) (3)
Selected topics in carbohydrate biochemistry: digestion and absorption of sugars in the intestinal tract. (1967) (3)
Heritable disorders of oxygen sensing (2021) (3)
Mitochondria as Vascular Oxygen Sensors: The Redox Hypothesis of Vascular O 2 Sensing (2003) (3)
Novel strategies for cancer therapy (2016) (3)
Fostering trust—J Mol Med’s scientific integrity policy (2008) (3)
hypoxia by HIF-1 Transcriptional regulation of vascular endothelial cell responses to (2013) (2)
ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization (2022) (2)
EC does it with HIF (2006) (2)
GENETIC STUDY OF HUMAN ADULT-TYPE HYPOLACTASIA BY ANALYSIS OF RESTRICTION FRAGMENT LENCHT POLYMORPHISHS (RFLPs) OF THE LACTASE GENE (1990) (2)
HIF1± And The Repair Of Injured Airway Microvasculature By Recipient-derived Tie2(+) Cells (2010) (2)
Excitation of Glomus Cells: Interaction Between Voltage-Gated K + Channels and Cholinergic Receptors (2003) (2)
SUCRASE-DEPENDENT SUGAR TRANSPORT ACROSS ARTIFICIAL LIPID MEMBRANES (1973) (2)
Detection of dipeptides and dipeptidase activity on paper (1957) (2)
Heritable disorders of oxygen sensing (2021) (2)
The transport systems for sugars in the small intestine. Reconstitution of one of them (1973) (2)
The identification of 'active acetate' as acetyl-CoA. (2001) (2)
Do pancreatic proteases play a role in processing prolactase and/or in the postweaning decline of lactase? (1995) (2)
From the handling editor (2000) (2)
Digoxin as an inhibitor of global hypoxia inducible factor-1α (HIF1α) expression and downstream targets in breast cancer: Dig-HIF1 pharmacodynamic trial. (2013) (2)
Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes (2017) (2)
151 years Berliner Klinische Wochenschrift and the 20th anniversary of the Journal of Molecular Medicine (2015) (2)
Molecular cell biology of brush border hydrolases : sucrase-isomaltase and gamma-glutamyl transpeptidase (1987) (2)
Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus (2013) (2)
Biosynthesis and Mode of Insertion of a Stalked Intrinsic Membrane Protein of the Small Intestinal Brush Border (1988) (2)
Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment. (2022) (2)
Regulation of angiogenesis and arteriogenesis by hypoxia-inducible factor-1 (2007) (2)
Recent advances in vascular biology and their clinical relevance (2009) (2)
Hypoxia-inducible factor-1 alpha deficiency correlates with impaired dermal wound healing in older diabetic mice (2007) (2)
[Intralesional therapy using recombinant interferon alpha 2 B in lesions of the uterine cervix caused by human papilloma virus]. (1989) (2)
The Na+/D-glucose co-transporter of the small-intestinal brush-border membrane. (1982) (2)
Serendipity, Generosity, and Inspiration (2016) (2)
[The quantitative disaccharidase activity of the human small intestine and acquired lactase deficiency in adults]. (1963) (2)
Interpreting intratumoral hypoxia: Can it guide therapy? (2007) (2)
Na+-dependent, electroneural L-ascorbate transport across brush border membrane vesicles from human small intestine: Inhibition by D-erythorbate. (1979) (2)
Structure-function relationships in the small-intestinal brush border membrane: a site of the merging of biochemistry, physiology and nutrition which Bottazzi indicated two thirds of a century ago. (1979) (2)
Oxygen Sensing In the Carotid Body and Othercells, Organs and Organelles (2003) (1)
PARTIAL HIF-1?? DEFICIENCY ATTENUATES ISCHEMIA REPERFUSION-MEDIATED GUT AND LUNG INJURY (2006) (1)
Correction: Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma (2021) (1)
Elevated Expression of Angiopoietin-like 4 in the Aqueous of Retinal Vein Occlusion Patients Who Develop Neovascular Glaucoma (2018) (1)
Transcription Factors and Human Disorders (2006) (1)
Enrichment of breast cancer stem cells following cytotoxic chemotherapy is mediated by hypoxia-inducible factors (2022) (1)
Extra-Hematopoietic Action of Erythropoietin (2009) (1)
Increasing severity of thermal injury causes delayed mobilization of circulating angiogenic cells (CACs) and impaired perfusion in a murine burn wound model (2008) (1)
Identification of hypoxia responsive genes regulated by the hypoxia inducible factor 1 (HIF-1) (2004) (1)
Reply to Lopez-Lazaro: Evidence that digoxin inhibits human cancer (2009) (1)
Is 15-min ischemia too lethal to be an ischemic preconditioning stimulus? (2006) (1)
Endothelin‐1 (ET‐1) induces hypoxia‐inducible factor 1 (HIF‐1) in Pulmonary Arterial Smooth Muscle Cells (PASMCs). (2008) (1)
Retina Expression Pattern of HIF-1 a and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy (2016) (1)
Blood vessels, disease pathogenesis, and novel therapies (2013) (1)
Oxygen Sensitivity of Central Cardiorespiratory Regions (2003) (1)
Delayed wound healing in aged mice is associated with diminished mobilization of circulating angiogenic cells (2010) (1)
T-Cell Activation under Hypoxic Conditions Enhances IFN- g Secretion (2009) (1)
Correction: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs (2021) (1)
Affinity Labeling of the Active Sites in the Complex from Small Intestine* (1)
Retraction for Lee et al., Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells (2022) (1)
Recovery of Perfusion After Limb Ischemia Effects of Aging and Hypoxia-Inducible Factor-1 Activity on Angiogenic Cell Mobilization (2007) (1)
Science Signaling Podcast: 12 February 2013 (2013) (1)
Stimulation of intestinal Na+/d-glucose cotransport by monoclonal antibodies (1988) (1)
A good‐bye and best wishes for the next millennium from the Managing Editor (1999) (1)
Neural Regulation of Hypoxia-Inducible Factors and 1 Redox State Drives the Pathogenesis of Hypertension 2 in a Rodent Model of Sleep Apnea 3 4 5 (2015) (1)
[Lactase phlorizin-hydrolase complex of the human small intestine]. (1972) (1)
Jean‐Pierre Ebel in memoriam (1992) (1)
Isolation and properties of sucrase from rabbit intestine. (1966) (1)
Retraction for Yuan et al., Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis (2022) (1)
Hypoxia colocalizes with increased levels of HIF-1 alpha and its angiogenic transcription products SDF-1 and VEGF in the burn wound (2009) (1)
Hypoxia inducible factor-1-dependent up-regulation ofBMP 4 mediateshypoxia-induced increaseofTRPC expression in PASMCs (2015) (1)
The small intestinal beta glycosidase lactase glycosyl ceramidase complex (1975) (1)
Role of intestinal disaccharidases in sugar transport. (1967) (1)
Shmuel Shaltiel. (2003) (1)
The Small Intestinal Na+, D-Glucose Cotransporter: a Likely Model (1983) (1)
Cell Death and Survival Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis (2013) (1)
Mechanisms of HIF‐1α Stabilization by Intermittent Hypoxia: Role of Ca2+‐mTOR signaling (2006) (1)
REGULATION OF SUCRASE-ISOMALTASE MESSANGER RNA CONCENTRATION IN RAT SMALL INTESTINE BY SUCROSE FEEDING (1989) (1)
MOLECULAR STUDY OF ADULT HYPOLACTASIA IN RABBIT AND HUMAN SMALL INTESTINE (1989) (1)
Excessive protein intake: a common cause of false-positive neonatal screening for tyrosinemia. (1987) (1)
CHARACTERIZATION OF SUCRASE-ISOMALTASE-PHOSPHOLIPID VESICLES BY ANALYTICAL ULTRACENTRIFUGATION (1981) (0)
Acriflavine Attenuates the Development of Hypoxic Pulmonary Hypertension (2011) (0)
Intermediary metabolism: Edited by Otto Hoffmann-Ostenhof Van Nostrand Reinhold Co.; New York, 1987 xviii + 493 pages. £63.95, $108.72 (1988) (0)
[Some properties of the alpha-glycerophosphate oxidase complex from the motochondria of rat liver]. (1958) (0)
Hypoxia Inducible Factor-1 Upregulates the Expression of Plasminogen Activator Inhibitor-1 in Retinal Endothelial Cells to Promote their Survival in Proliferative Diabetic Retinopathy Patients (2015) (0)
Senile cataractic lenses do not accumulate galactitol in either lactose tolerant or intolerant subjects. (1993) (0)
Intestinal Digestion and Absorption of Sugars and Peptides. (1970) (0)
Role of intestinal disaccharidases in sugar transport (2005) (0)
ic andhypoxia-inducibl e expression ofthehuman erythropoietin geneintransgenic mice (enhancer elements/gene regulation/in situ hybridization/polycythemia) (1991) (0)
SUGAR TRANSPORT ACROSS THE INTESTINAL BRUSH BORDER MEMBRANE: INHIBITION OF THE Na+-DEPENDENT d-GLUCOSE FLUX BY AMINO GROUP REAGENTS (1981) (0)
Preface to Volume 36 (1986) (0)
Anchoring and Biosynthesis of Small-Intestinal Sucrase-Isomaltase (2006) (0)
Chapter 9 - Impact of future climate changes on high pollution levels (2006) (0)
[On the heterogenity of desoxyribonucleic acid]. (1959) (0)
[A disaccharidase associated glucose transport system]. (1972) (0)
Preface to Volume 35 (1983) (0)
Effective cancer immunotherapy further linked to regulating a cell 'suicide' gene (2020) (0)
Regulation of intestinal lactasephlorizin hydrolase (1990) (0)
Abstract 378: Endothelial Cell Hypoxia-inducible Factor (HIF) Activity is Necessary for Right Ventricular Remodeling in a Murine Model of Chronic-hypoxic Pulmonary Hypertension (2015) (0)
MS3-2: HIF-1, Metabolism, and Breast Cancer Metastasis. (2011) (0)
Regulation of type II nitric oxide synthase (NOS) expression by hypoxia (1996) (0)
SelectiveInhibitionofHypoxia-InducibleFactor(HIF) Prolyl-Hydroxylase1MediatesNeuroprotectionagainst NormoxicOxidativeDeathviaHIF-andCREB-Independent Pathways (2009) (0)
Inhibition of HIF-1α reduces tumor growth and angiogenesis of human gastric cancer (2004) (0)
The enzymes of biological membranes: Volume 1: Physical and chemical techniques Edited by Anthony Martonosi John Wiley; Chichester, 1976 xiii + 257 pages. £ 10.50, $ 20.00; Volume 2: Bios (1977) (0)
Editorial (0)
NARF is a hypoxia-induced coactivator for OCT4-mediated breast cancer stem cell specification (2022) (0)
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension (2019) (0)
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness (2022) (0)
Pulmonary Arterial Smooth Muscle Cells 2 + Intracellular Ca Hypoxia Inducible Factor 1 Mediates Hypoxia-Induced TRPC Expression and Elevated (2006) (0)
PNAS Plus Significance Statements (2015) (0)
THE MODE OF ANCHORING OF SUCRASE-ISOMALTASE TO THE SMALL-INTESTINAL BRUSH BORDER MEMBRANE AND ITS BIOSYNTHETIC IMPLICATIONS (1980) (0)
(from the June 1987 Ljubljana issue, updated) (1988) (0)
Preface (1985) (0)
Abstract P3-07-62: Association of overexpression of hypoxia inducible factor 1α with response to neoadjuvant chemotherapy in early stage breast cancer (2016) (0)
von Hippel-Lindau Tumor Suppressor, Hypoxia-Inducible Factor-1, and Tumor Vascularization (2010) (0)
Abstract 3066: Chemotherapy-induced GSTO1 interacts with ryanodine receptor RYR1 to trigger Ca2+-dependent breast cancer stem cell enrichment (2018) (0)
Molecular and Cellular Pathobiology CollagenProlyl HydroxylasesAreEssential for BreastCancer Metastasis (2013) (0)
Effect of Digoxin on Hypoxic Pulmonary Hypertension (HPH) (2010) (0)
Transcriptional Responses Mediated by Hypoxia-Inducible Factor 1 (1998) (0)
Glycolytic Shunt Pathways Are Reprogrammed in Hypoxic Breast Cancer Cells (2016) (0)
Accumulation of Hypoxia Inducible Factor-1α in Retinal Cells in Response to Acute Hypoglycemia is Necessary for Survival (2015) (0)
Burn wound homing of bone marrow-derived angiogenic cells is impaired by conditional knock out of the hypoxia-inducible factor 1beta gene (2011) (0)
Editorial (0)
Editorial (2001) (0)
Hypoxia Up-Regulates Genes of Lipid Biosynthesis Via Hypoxia Inducible Factor 1 (HIF-1). (2009) (0)
injurye/resuscitation-induced hepatic Selective inhibition of iNOS attenuates (2015) (0)
Next-gen cancer research (2017) (0)
Chapter 7 – Parallel computations (2006) (0)
[Limits of interpretation of the curve of enzyme activity in relation to pH]. (1957) (0)
Transient Hypoglycemic Episodes Increase Hypoxia Inducible Factor-1α Nuclear Accumulation and Enhances the Angiogenic Response in Diabetic Eye Disease (2017) (0)
Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes (2017) (0)
Chaperone-Mediated Autophagy Targets HIF-1 α for Lysosomal Degradation (2013) (0)
PHOTOACTIVATABLE REAGENTS IN PROBING THE PROTEIN-LIPID INTERFACE OF MEMBRANES (1983) (0)
Increased vascularization VEGF and HIF-1 expression in myocardium of chronically anemic fetal sheep (1997) (0)
[Surgical therapy in high-risk patients with endometrial adenocarcinoma]. (1989) (0)
A letter from the managing editor (1986) (0)
Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization (2019) (0)
PHOTOINACTIVATION OF THE SMALL-INTESTINAL d-GLUCOSE TRANSPORTER WITH A 6-SUBSTITUTED PHLORIZIN ANALOGUE (1981) (0)
Editorial (0)
Title: Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer (2014) (0)
A Nuclear Factor Induced byHypoxia viaDeNovoProtein Synthesis BindstotheHumanErythropoietin GeneEnhancer ataSite Required forTranscriptional Activation (1992) (0)
pathwaythe inducible nitric oxide synthase trauma-hemorrhage-induced increase in caspase-3 by Androstenediol inhibits the (2015) (0)
Editorial overview: Hypoxia (2019) (0)
Yuri A. Ovchinnikov (1988) (0)
Involvement of Hypoxia-Inducible Factor 1 in Physiological and Pathological Responses to Continuous and Intermittent Hypoxia: Role of Reactive Oxygen Species (2011) (0)
The Journal of Clinical Investigation in the time of COVID-19. (2021) (0)
Forum Review HIF-1-Dependent Respiratory, Cardiovascular, and Redox Responses to Chronic Intermittent Hypoxia (2007) (0)
A Novel EGLN1/PHD2 High-Frequency Variant in Tibetans Protects Against Hypoxia-Induced Polycythemia. (2012) (0)
Activation of Lysine Demethylases (KDM's) by Intermittent Hypoxia (2019) (0)
Cancer Therapy : Preclinical Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer (2014) (0)
a Ligand and Its Receptor von Hippel-Lindau Loss-of-Function Induces Expression of Hemangioblastoma and Clear Cell-Renal Cell Carcinoma : and CXCR 4 Expression in α Derived Factor-1 − Stromal Cell (2005) (0)
Shifting paradigms for ischaemic preconditioning AUTHOR’S RETROSPECTIVE (2012) (0)
[Contribution to an antigen analysis of Walker carcinosarcoma 256 in rats]. (1963) (0)
Increased Ratios of Internal Organ Volume to Body Mass in Chuvash Polycythemia and HIF-2α Repression of p21Cip Expression through C-MYC. (2009) (0)
AJP-Cell Theme: Cellular Responses to Hypoxia. (2015) (0)
Regulation of carotid body oxygen sensing by hypoxia-inducible factors (2015) (0)
Hypoxia-inducible factor 1α: Essential role in cardiovascular development and physiology (1998) (0)
Hypoxia-Inducible Factor-1, and Tumor Vascularization (2009) (0)
Hypoxia Inducible Factor-1α Promotes the Survival of Retinal Pigment Epithelial Cells Exposed to Oxidative Stress (2015) (0)
Advances in cancer biology and therapy (2013) (0)
Gas biology: small molecular medicine (2012) (0)
Adenovirus-Mediated Hypoxia Inducible Factor (HIF)-1Alpha Gene Transfer Promotes Repair Of Airway Allograft Microvasculature And Attenuates Fibrosis (2011) (0)
Chromatin , Gene , and RNA Regulation Decreased Expression of Cystathionine b-Synthase Promotes Glioma Tumorigenesis (2014) (0)
HIF‐2α Deficiency Induces Carotid Body Sensory Long‐Term Facilitation (2015) (0)
Biologic C orrelates o f 18 Fluorodeoxygluco se U ptake i n Human B reast C ancer M easured b y P ositron E mission Tomography (2002) (0)
[Absorption of sugars in the small intestine]. (1976) (0)
Increased expression of fractalkine and its receptor in mouse hind limb ischemic tissues and bone marrow-derives stem cells under hypoxic condition (2006) (0)
Abstract 1521: Hypoxia inducible factor is an important regulator of metastatic niche formation (2011) (0)
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer (2013) (0)
The role of HIF-1 and ROS in cellular and systemic responses to chronic intermittent hypoxia (2011) (0)
Hypoxia is a common finding in advanced human tumors and is often associated with metastatic dissemination and poor prognosis (2014) (0)
Homeostatic Regulation by Hypoxia-Inducible Factor 1 Hypoxia (2019) (0)
Biochemische Mechanismen der Zuckerresorption in Enterozyten (1979) (0)
Spotlight on...Giorgio Semenza. Interview by Daniela Ruffell. (2010) (0)
Regulation of HIF‐alpha isoform expression and redox state by carotid body chemosensory reflex (710.5) (2014) (0)
Cancer energy metabolism (2005) (0)
Preface To Volume 42 (2003) (0)
Interaction of brush border hydrolytic enzymes and carriers. (1972) (0)
[A new unusual enzyme: alpha-glycerophosphate oxidase of mitochondria of the liver in rats]. (1957) (0)
Non‐transcriptional Role of HIF‐2α in Hypoxia‐Evoked hERG K+ Channel Trafficking (2015) (0)
Risk of Severe Oxygen-Induced Retinopathy in Neonatal Rats Hydrogen Peroxide Accumulation in the Choroid During Intermittent Hypoxia Increases (2015) (0)
Oropharyngeal Cancer Predictive and Prognostic Parameter in the Radiotherapy of : A Novel α Expression of Hypoxia-inducible Factor-1 Updated (2001) (0)
On the primary site of control in the spontaneous sucrase-isomaltase after developmek of small-intestinal birth (1986) (0)
The first issue of FEBS Letters appeared in July 1968. (1998) (0)
Editorial (0)
Cancer Cell Antitumorigenic Effect of Antioxidants in patients with head and neck or lung cancer (0)
Gaseous messengers in oxygen sensing (2012) (0)
HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia (2022) (0)
ANCHORING AND BIOSYNTHESIS OF THE MAJOR INTRINSIC PROTEIN OF THE SMALL-INTESTINAL BRUSH BORDER MEMBRANE (1983) (0)
Abstract 525: PHD3-mediated prolyl hydroxylation of non-muscle actin impairs polymerization and cell motility (2015) (0)
Regulation Of Histone 3 Acetylation By Intermittent Hypoxia (2017) (0)
Induction of Hypoxia-Inducible Factor-1 (HIF-1) in Adult and Neonatal Rat Brain: Possible Relationship to Hypoxia-induced Tolerance to Ischemia (2001) (0)
Editorial (0)
Preface to volume 46: (Vol. XI of the “Stories of Success. Personal Recollections) (2008) (0)
[Cancer of the cervix uteri in pregnancy: surgical treatment with conservation of the ovaries. Clinical case]. (1989) (0)
低酸素誘導因子(HIF-1)による虚血肢の血流改善 (2006) (0)
[Functions of iron-sulfur proteins in energy metabolism]. (1972) (0)
Biographical sketch—Gregg L. Semenza (2007) (0)
Study of hypoxia in human head and neck tumors by pimonidazole binding and HIF-1 alpha expression (2002) (0)
The Small-Intestinal Sucrase—Isomaltase Complex: Reconstitution of Sucrase—Isomaltase-dependent Sugar Transport with Black Lipid Membranes (1974) (0)
Carotid Body Chemoreflex–Dependent Activation Of Epigenetic Mechanisms (2017) (0)
Abstract 5427: Inhibition of hypoxia-inducible factor 1 (HIF-1) transcriptional activity and cell mobility via G9a/GLP-mediated methylation of HIF-1α (2018) (0)
Monoclonal A ntibodies to Integral Membrane Transport and Receptor Proteins Novel Reagents for Protein Purification (1985) (0)
The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization (2016) (0)
Preface to Volume 45: Stories of Success – Personal Recollections. X (2007) (0)
Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. (2023) (0)
THE SILENT CARRIER ALLELE: β-THALASSEMIA WITHOUT A MUTATION IN THE β-GLOBIN GENE REGION (1984) (0)
Transcriptional mechanisms of neuroprotection by iron chelators (2008) (0)
Preface to volume 43 (2004) (0)
Chapter 11 – Discussion of some open questions (2006) (0)
Preface to volume 41 (2000) (0)
2017 SfRBM Discovery Award Lecture Maintenance Of Oxygen And Redox Homeostasis By Hypoxia-Inducible Factor 1 (2017) (0)
Angiopoietin-like 4 is a Potent Angiogenic Factor in Patients with Proliferative Diabetic Retinopathy (2014) (0)
Abstract 505: Hypoxia inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. (2013) (0)
Disruption of the HIF-1 pathway in individuals with Ollier disease and Maffucci syndrome (2022) (0)
Editorial: change of managing editor (1985) (0)
Homeostatic responses to hypoxia by the carotid body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α (2022) (0)
Correction: PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis. (2022) (0)
KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi’s sarcoma (2015) (0)
Correction (2018) (0)
Abstract 2319: Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. (2013) (0)
Regulation of Insulin Metabolism by Intermittent Hypoxia. Molecular Mechanisms (2015) (0)
Graft microvascular disease in solid organ transplantation (2014) (0)
Genomics of Oxygen Sensing (2003) (0)
Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis (2012) (0)
Preface to Volume 37 (1990) (0)
Cancer Metabolism, HIF‐1, and Novel Anti‐Cancer Therapies (2012) (0)
Abstract 4088: Targeting glutamine metabolism in breast cancer (2011) (0)
NADPH oxidase is critical for up‐regulation of HIF‐1[alpha] by intermittent hypoxia (2008) (0)
Intestinal membrane-bound carbohydrases. (1977) (0)
Editorial (0)
Protection Against Myocardial Ischemia / Reperfusion Injury Phosphatidylinositol-3-Kinase Signaling Is Required for Erythropoietin-Mediated Acute (2004) (0)
Ca2+ Mediates HIF-dependent Upregulation of Aquaporin 1 in Pulmonary Arterial Smooth Muscle Cells (2021) (0)
5 Hypoxia-inducible factor 1 in cancer pathogenesis and therapy (2009) (0)
How I Became a Biochemist (2002) (0)
Corrigendum to: Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells. (2021) (0)
HIF-1 Blockade Inhibits Gastric Cancer Growth in Mice (2004) (0)
S. Prakash Datta (1920–2010) (2010) (0)
Book reviewMembranes and their cellular functions : by J. B. Finean, R. Coleman and R. H. Mitchell Halstead Press; New York; Blackwell Scientific Publications; Oxford, London, Edinburgh, Victoria, 1974 vii + 123 pages. £ 2.80 (1976) (0)
THE Na+-GLUCOSE COTRANSPORTER OF THE SMALL INTESTINAL BRUSH BORDER MEMBRANE: AN ASYMMETRIC GATED CHANNEL (OR PORE) RESPONSIVE TO ΔΨ (1983) (0)
that Induces HIF-1α Expression (2006) (0)
derived angiogenic cells in ischemic tissue - marrow Metabolic reprogramming by HIF-1 promotes the survival of bone (2013) (0)
regions of the rostral ventrolateral medulla Expression of heme oxygenase in the oxygen-sensing (2015) (0)
Editor's Note: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis. (2022) (0)
Endothelial Biomedicine: Hypoxia-Inducible Factor 1 (2007) (0)
Signaling Pathways That Protect the Heart Against Apoptosis Induced by Ischemia and Reperfusion (2006) (0)
hypoxia activation by chronic intermittent (2014) (0)
Preface to Volume 38 (1995) (0)
Involvement of hypoxia-inductible factor 1 in preinvasive and early-stage cancer (2005) (0)
cardiorespiratory physiology by HIF-1-regulated gene expression : transcriptional control of 2 (2004) (0)
Hypoxia-Inducible Factor 1-Regulated Angiogenic Cytokines in Prolifeartive Diabetic Retinopathy (2017) (0)
The cancer connection : von Hippel – Lindau disease (2016) (0)
Monoclonal Antibodies to Integral Membrane Transport and Receptor Proteins (1985) (0)
Chapter 8 - Studying high pollution levels (2006) (0)
Differential regulation of vascular endothelial growth factor during ventilated pulmonary ischemia. (1999) (0)
Daily administration of low-dose daunorubicin or doxorubicin inhibits hypoxia-inducible factor 1 and tumor vascularization (2022) (0)
Part one: Genomics of oxygen sensing (2003) (0)
15. ON THE PRIMARY SITE OF CONTROL IN SPONTANEOUS AND IN GLUCOCORTICOID-TRIGGERED PRECOCIOUS DEVELOPMENT OF SMALL-INTESTINAL SUCRASE-ISOMALTASE COMPLEX (1987) (0)
Novel strategies for cancer therapy (2016) (0)
ABSENCE OF CAROTID BODY RESPONSES TO CHRONIC INTERMITTENT HYPOXIA IN MICE DEFICIENT IN HIF‐1á: Implications in cardio‐respiratory responses. (2006) (0)
Persistent HIF‐1 Activation by Long‐Term Intermittent Hypoxia (2019) (0)
Physiological and Therapeutic Vascular Remodeling Mediated by Hypoxia-Inducible Factor 1 (2011) (0)
Next-gen cancer research (2017) (0)
Hypoglycemia Promotes Pathological Angiogenesis by a p38-Dependent Increase in Hypoxia Inducible Factor-1α Nuclear Accumulation (2020) (0)
Hypoxia-inducible Factors Sirtuin-7 Inhibits the Activity of Gene Regulation : (2013) (0)
Regulation of Ischemia-Induced Vascularization by Hypoxia-Inducible Factor 1 (2008) (0)
Retraction for Lee et al., Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization (2023) (0)
Correction (2021) (0)
The HIF-1 Family of bHLH-PAS Proteins: Master Regulators of Oxygen Homeostasis (2003) (0)
Expression Pattern of HIF-1α and HIF-1-Regulated Angiogenic Mediators Suggests Utility of Circumferential Scatter Laser for Proliferative Sickle Retinopathy (2016) (0)
Blood vessels, disease pathogenesis, and novel therapies (2013) (0)
Abstract A3: Collagen hydroxylases are essential for breast cancer metastasis (2013) (0)
[HEREDITARY SACCHAROSE AND ISOMALTOSE MALABSORPTION]. (1964) (0)
Preface to volume 40 (1997) (0)
[Use of labeled glucose in intestinal absorption in vitro]. (1967) (0)
Editorial (0)
Hypoxia-inducible factor 1 and breast cancer metastasis (2015) (0)
FEBS announcement (0)
Editorial (0)
Forum News & Views ROS Signaling in Systemic and Cellular Responses to Chronic Intermittent Hypoxia (2007) (0)
Supplementary Materials for Matrix Rigidity Controls Endothelial Differentiatio n and Morphogenesis of Cardiac Precursors (2012) (0)
Further investigations on the Physico—Chemical characteristics of the DNAs from normal and leukaemic human leukocytes Solubility pattern and ultracentrifugal and electrophoretic characteristics (2010) (0)
Transport by Proteins : Edited by G. Blauer and H. Sund Walter de Gruyter; Berlin, New York, 1978 xvi + 420 pages. DM 145.00 (hardcover) (1980) (0)
Chapter 6 – Efficient organization of the matrix computations (2006) (0)
Mechanisms of cooperativity and allosteric regulation in proteins : By M. Perutz; Cambridge University Press; Cambridge, 1990; x + 101 pages; £11.95, $17.95 (1991) (0)
Does Loss of CD 151 Expression Promote theMetastasis of Hypoxic Colon Cancer Cells ? 55 (2008) (0)
from the June 1987 Ljubljana issue, updated (0)

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