Gregory Petsko
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Molecular Biology
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Biology
Gregory Petsko's Degrees
- Bachelors Chemistry Princeton University
Why Is Gregory Petsko Influential?
(Suggest an Edit or Addition)According to Wikipedia, Gregory A. Petsko is an American biochemist and member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. He is currently Professor of Neurology at the Ann Romney Center for Neurologic Diseases at Harvard Medical School and Brigham and Women's Hospital. He formerly had an endowed professorship in Neurology and Neuroscience at Weill Cornell Medical College and is still an adjunct professor of Biomedical Engineering at Cornell University, and is also the Gyula and Katica Tauber Professor, Emeritus, in biochemistry and chemistry at Brandeis University. On October 24, 2023, in a ceremony in the East Room of the White House, President Joe Biden presented Gregory Petsko and eight others with the National Medal of Science, the highest honor the United States can bestow on a scientist and engineer.
Gregory Petsko's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Aromatic-aromatic interaction: a mechanism of protein structure stabilization. (1985) (2012)
- The catalytic pathway of cytochrome p450cam at atomic resolution. (2000) (1082)
- The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization (2004) (1076)
- The past is a foreign country (2010) (1024)
- Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. (1990) (1005)
- Temperature-dependent X-ray diffraction as a probe of protein structural dynamics (1979) (988)
- Molecular dynamics simulations in biology (1990) (882)
- Transformation (2006) (824)
- Intrinsic motions along an enzymatic reaction trajectory (2007) (782)
- The dark side (2000) (692)
- Weakly polar interactions in proteins. (1988) (628)
- Amino‐aromatic interactions in proteins (1986) (605)
- Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5Å resolution: using amino acid sequence data (1975) (595)
- “Sleeping Beauty”: Quiescence in Saccharomyces cerevisiae (2004) (578)
- Chemistry and biology. (2000) (555)
- Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins. (1998) (506)
- Crystalline ribonuclease A loses function below the dynamical transition at 220 K (1992) (496)
- CEACAM1 regulates TIM-3-mediated tolerance and exhaustion (2014) (455)
- Cavities in proteins: structure of a metmyoglobin-xenon complex solved to 1.9 A. (1984) (448)
- Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis (1990) (435)
- A soluble α-synuclein construct forms a dynamic tetramer (2011) (424)
- Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. (2005) (372)
- X-ray structure and refinement of carbon-monoxy (Fe II)-myoglobin at 1.5 A resolution. (1986) (365)
- Effects of temperature on protein structure and dynamics: X-ray crystallographic studies of the protein ribonuclease-A at nine different temperatures from 98 to 320 K. (1993) (338)
- Solvent mobility and the protein 'glass' transition (2000) (335)
- Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations (2015) (331)
- The evolution of a/ barrel enzymes (1990) (325)
- The oxidation state of DJ-1 regulates its chaperone activity toward α-synuclein (2006) (304)
- The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease (2003) (303)
- POVScript+: a program for model and data visualization using persistence of vision ray-tracing (2003) (297)
- Anatomy of a conformational change: hinged "lid" motion of the triosephosphate isomerase loop. (1990) (265)
- Crystallographic refinement by simulated annealing: application to crambin (1989) (230)
- Structure of yeast triosephosphate isomerase at 1.9-A resolution. (1990) (228)
- Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution. (1997) (226)
- Structure of the Mg(2+)-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis. (1994) (220)
- Fluctuations in protein structure from X-ray diffraction. (1984) (218)
- Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease. (2006) (211)
- The crystal structure of a post‐synaptic neurotoxin from sea snake at 2.2 Å resolution (1976) (210)
- Conformational substates in a protein: structure and dynamics of metmyoglobin at 80 K. (1982) (200)
- Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5-A resolution: implications for catalysis. (1990) (200)
- Computer simulation and analysis of the reaction pathway of triosephosphate isomerase. (1991) (199)
- Economies of scale (2012) (199)
- The 'glass transition' in protein dynamics: what it is, why it occurs, and how to exploit it. (2003) (197)
- Dimerization energetics of benzene and aromatic amino acid side chains (1986) (196)
- On the three-dimensional structure and catalytic mechanism of triose phosphate isomerase. (1981) (195)
- A Yeast Model of FUS/TLS-Dependent Cytotoxicity (2011) (195)
- Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease. (2020) (194)
- A Topographic View of Supercooled Liquids and Glass Formation (2005) (185)
- Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway. (1991) (185)
- Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations (2018) (183)
- Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein (2016) (181)
- Pharmacological chaperones stabilize retromer to limit APP processing. (2014) (181)
- The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. (2006) (175)
- An Experimental Approach to Mapping the Binding Surfaces of Crystalline Proteins (1996) (172)
- Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1. (2006) (169)
- How Enzymes Work (2008) (167)
- Misfolded Proteins Are Competent to Mediate a Subset of the Responses to Heat Shock in Saccharomyces cerevisiae * 210 (2002) (166)
- Retromer in Alzheimer disease, Parkinson disease and other neurological disorders (2015) (165)
- The crystal structure of benzoylformate decarboxylase at 1.6 A resolution: diversity of catalytic residues in thiamin diphosphate-dependent enzymes. (1998) (160)
- Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme. (1994) (160)
- Effect of anisotropy and anharmonicity on protein crystallographic refinement. An evaluation by molecular dynamics. (1986) (156)
- Reaction of myoglobin with phenylhydrazine: a molecular doorstop. (1984) (148)
- Mapping protein dynamics by X-ray diffraction. (1985) (146)
- Structural basis of thermostability in hyperthermophilic proteins, or "there's more than one way to skin a cat". (2001) (146)
- Multiple solvent crystal structures: probing binding sites, plasticity and hydration. (2006) (142)
- The walking dead (2011) (141)
- Climate change and the integrity of science. (2010) (137)
- A Christmas Carol (2001) (136)
- Crystal structures of Escherichia coli and Salmonella typhimurium 3-isopropylmalate dehydrogenase and comparison with their thermophilic counterpart from Thermus thermophilus. (1997) (136)
- Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease (2015) (135)
- Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity. (1995) (135)
- [19]Study of protein dynamics by X-ray diffraction (1986) (132)
- Protein crystallography at sub-zero temperatures: cryo-protective mother liquors for protein crystals. (1975) (131)
- Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. (2009) (123)
- On the origin of enzymatic species. (1993) (122)
- Structural mechanism of enoyl-CoA hydratase: three atoms from a single water are added in either an E1cb stepwise or concerted fashion. (2002) (121)
- Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis. (2005) (117)
- Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins (1997) (117)
- Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole (2006) (117)
- Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous (1990) (116)
- Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator. (2000) (116)
- Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-A resolution: identification of the active site and possible catalytic residues. (1991) (116)
- Polyamine pathway contributes to the pathogenesis of Parkinson disease (2010) (115)
- An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. (1994) (114)
- Atomic coordinates for triose phosphate isomerase from chicken muscle. (1976) (113)
- Triosephosphate isomerase: removal of a putatively electrophilic histidine residue results in a subtle change in catalytic mechanism. (1988) (111)
- 26-10 Fab-digoxin complex: affinity and specificity due to surface complementarity. (1993) (110)
- Protein misfolding and temperature up-shift cause G1 arrest via a common mechanism dependent on heat shock factor in Saccharomyces cerevisiae (2001) (109)
- Mechanism of the Quorum-Quenching Lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate Modeling and Active Site Mutations† (2008) (105)
- Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95. (1991) (105)
- Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1 (2015) (103)
- Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model (2013) (103)
- Q&A: What are pharmacological chaperones and why are they interesting? (2009) (101)
- Proteins at work: "stop-action" pictures at subzero temperatures. (1984) (101)
- The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily. (2004) (99)
- Crystal cryocooling distorts conformational heterogeneity in a model Michaelis complex of DHFR. (2014) (99)
- When bubbles burst (2008) (97)
- Crystallographic studies of the mechanism of xylose isomerase. (1989) (97)
- The 2.1-A resolution structure of iron superoxide dismutase from Pseudomonas ovalis. (1990) (95)
- Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease (2017) (95)
- X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis. (1994) (95)
- The refined crystal structure of subtilisin Carlsberg at 2.5 A resolution. (1988) (95)
- Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens. (2007) (94)
- Control of oligomeric enzyme thermostability by protein engineering. (1987) (93)
- The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: mechanistic and crystallographic evidence for stereospecific alkylation by (R)-alpha-phenylglycidate. (1994) (93)
- Mechanism of the Quorum-Quenching Lactonase (AiiA) from Bacillus thuringiensis. 1. Product-Bound Structures†‡ (2008) (91)
- Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae. (1995) (90)
- Testing geometrical discrimination within an enzyme active site: constrained hydrogen bonding in the ketosteroid isomerase oxyanion hole. (2008) (89)
- Defining the mandate of proteomics in the post-genomics era: workshop report. (2002) (89)
- Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the D270N mutant. (1995) (88)
- Thermal expansion of a protein. (1987) (87)
- Study of protein dynamics by X-ray diffraction. (1986) (87)
- Big science, little science (2009) (87)
- 2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor. (2003) (87)
- Crystal structure of elastase–substrate complex at −55 °C (1976) (82)
- Evolution of an enzyme active site: the structure of a new crystal form of muconate lactonizing enzyme compared with mandelate racemase and enolase. (1998) (82)
- Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase (2009) (82)
- Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy (2016) (82)
- Analogous inhibitors of elastase do not always bind analogously (1994) (81)
- Structure of oxidized flavodoxin from Anacystis nidulans. (1983) (80)
- Transnitrosylation from DJ-1 to PTEN Attenuates Neuronal Cell Death in Parkinson's Disease Models (2014) (80)
- Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution. (1994) (80)
- A transport problem? (1990) (80)
- Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis (2010) (78)
- Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten. (1991) (78)
- Do the math (2006) (77)
- Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain (2012) (75)
- Tsunami (2005) (71)
- My worries are no longer behind me (2007) (71)
- The evolution of alpha/beta barrel enzymes. (1990) (71)
- Structure of iron superoxide dismutase from Pseudomonas ovalis at 2.9-A resolution. (1983) (70)
- A comparison between molecular dynamics and X-ray results for dissociated CO in myoglobin (1997) (69)
- Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein (2018) (69)
- Three-dimensional structure of neurotoxin a from venom of the Philippines sea snake. (1977) (68)
- Apocalypse now? (2019) (68)
- Transition-state analogues in protein crystallography: probes of the structural source of enzyme catalysis. (1990) (68)
- Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid. (1994) (67)
- Mechanism of the reaction catalyzed by mandelate racemase: importance of electrophilic catalysis by glutamic acid 317. (1995) (65)
- The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parkinsonism-associated protein DJ-1. (2005) (65)
- Isotopic exchange plus substrate and inhibition kinetics of D-xylose isomerase do not support a proton-transfer mechanism. (1994) (65)
- Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinephosphonic acid. Spectroscopic and crystallographic characterization of the transition state of peptide hydrolysis. (2001) (65)
- The usual suspects (2003) (64)
- No stone unturned (2010) (63)
- Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. (2012) (62)
- Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis (2014) (62)
- Structural dynamics of liganded myoglobin. (1980) (62)
- AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease. (2018) (62)
- Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis. (2002) (61)
- Analysis of two-residue turns in proteins. (1994) (60)
- Molecular mechanics calculations on cis ([Pt(NH3)2{d(GpG)}] adducts in two oligonucleotide duplexes (1985) (60)
- Direct structural observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate by elastase. (1994) (60)
- Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis. (1999) (57)
- Structure of a Michaelis complex analogue: propionate binds in the substrate carboxylate site of alanine racemase. (1999) (57)
- Mandelate Racemase: Structure-Function Studies of a Pseudosymmetric Enzyme (1995) (56)
- Solution of a Protein Crystal Structure with a Model Obtained from NMR Interproton Distance Restraints (1987) (56)
- Xylose isomerase in substrate and inhibitor michaelis States: atomic resolution studies of a metal-mediated hydride shift(,). (2004) (55)
- The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase. (2003) (55)
- Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase. (2001) (54)
- Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT (2013) (54)
- An idea whose time has gone (2007) (54)
- Preparation of isomorphous heavy-atom derivatives. (1985) (53)
- Protein crystallography at sub-zero temperatures: lysozyme-substrate complexes in cooled mixed solvents. (1975) (52)
- Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis. (2011) (52)
- mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging (2020) (52)
- Xylose isomerase in substrate and inhibitor michaelis states: atomic resolution studies of a metal-mediated hydride shift. (2004) (52)
- Subunit interface of triosephosphate isomerase: site-directed mutagenesis and characterization of the altered enzyme. (1987) (52)
- Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. (2004) (51)
- Parkinson’s Disease and Melanoma: Co-Occurrence and Mechanisms (2018) (51)
- Design, synthesis, and characterization of a potent xylose isomerase inhibitor, D-threonohydroxamic acid, and high-resolution X-ray crystallographic structure of the enzyme-inhibitor complex. (1995) (51)
- The 1.20 A resolution crystal structure of the aminopeptidase from Aeromonas proteolytica complexed with tris: a tale of buffer inhibition. (2002) (50)
- The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant. (1997) (50)
- Sequence and homology model of 3-isopropylmalate dehydrogenase from the psychrotrophic bacterium Vibrio sp. I5 suggest reasons for thermal instability. (1997) (49)
- The Rosetta Stone (2001) (48)
- Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. (2013) (48)
- Structure and function of snake venom curarimimetic neurotoxins. (1981) (47)
- Electrostatic interactions in aromatic oligopeptides contribute to protein stability (1989) (47)
- The role of mobility in the substrate binding and catalytic machinery of enzymes. (1983) (46)
- The 3.0 A crystal structure of xylose isomerase from Streptomyces olivochromogenes. (1987) (46)
- The structural enzymology of proton-transfer reactions (1993) (45)
- Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals. (2003) (45)
- Evidence of the participation of remote residues in the catalytic activity of Co-type nitrile hydratase from Pseudomonas putida. (2011) (45)
- Molecular mechanics modeling of oligonucleotide adducts of the antitumor drug cis‐diamminedichloroplatinum(II) (1987) (44)
- The role of water in the catalytic efficiency of triosephosphate isomerase. (1999) (44)
- Ribonuclease structure and catalysis: crystal structure of sulfate-free native ribonuclease A at 1.5-A resolution. (1987) (44)
- Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 2. Structural basis of hapten binding and idiotypy. (1991) (43)
- Structure and activity of two photoreversible cinnamates bound to chymotrypsin. (1990) (42)
- Interaction of a peptidomimetic aminimide inhibitor with elastase. (1995) (41)
- Grain of truth (2002) (41)
- Crystallography and site-directed mutagenesis of yeast triosephosphate isomerase: what can we learn about catalysis from a "simple" enzyme? (1987) (40)
- Observation of unstable species in enzyme-catalyzed transformations using protein crystallography. (2000) (40)
- Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage. (2013) (40)
- The x-ray structure of the periplasmic galactose binding protein from Salmonella typhimurium at 3.0-A resolution. (1983) (40)
- High-salt and low-salt models for kinked adducts of cis-diamminedichloroplatinum(II) with oligonucleotide duplexes (1986) (39)
- Size doesn't matter (2001) (39)
- Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the K166R mutant. (1995) (39)
- Why protein R‐factors are so large: A self‐consistent analysis (2002) (39)
- Photolysis and deacylation of inhibited chymotrypsin. (1990) (38)
- Composition analysis of α-helices in thermophilic organisms (1995) (38)
- Molecular graphics: application to the structure determination of a snake venom neurotoxin. (1977) (38)
- 1-Butaneboronic acid binding to Aeromonas proteolytica aminopeptidase: a case of arrested development. (1999) (38)
- Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site (2013) (37)
- Mycobacterium tuberculosis Hip1 Modulates Macrophage Responses through Proteolysis of GroEL2 (2014) (36)
- Crystal structure of 3-carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida, a fumarase class II type cycloisomerase: enzyme evolution in parallel pathways. (2004) (36)
- PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function (2020) (36)
- Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester. (2008) (35)
- Crystal structure of the K12M/G15A triosephosphate isomerase double mutant and electrostatic analysis of the active site. (1994) (35)
- When failure should be the option (2010) (35)
- Zinc coordination geometry and ligand binding affinity: the structural and kinetic analysis of the second-shell serine 228 residue and the methionine 180 residue of the aminopeptidase from Vibrio proteolyticus. (2008) (35)
- Diversity in hapten recognition: structural study of an anti-cocaine antibody M82G2. (2005) (34)
- A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis. (2013) (34)
- 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner (2020) (33)
- Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6. (2000) (33)
- Activity and structure of the active-site mutants R386Y and R386F of Escherichia coli aspartate aminotransferase. (1991) (33)
- Spectroscopic and X-ray crystallographic characterization of bestatin bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica. (2004) (32)
- Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion (2016) (32)
- Observation of the light-triggered binding of pyrone to chymotrypsin by Laue x-ray crystallography. (1991) (32)
- The role of residues outside the active site: structural basis for function of C191 mutants of Escherichia coli aspartate aminotransferase. (2000) (32)
- X-ray Laue diffraction from crystals of xylose isomerase. (1988) (32)
- Inactivation and destruction of conserved Trp159 of Fe-superoxide dismutase from Porphyromonas gingivalis by hydrogen peroxide. (1998) (31)
- Hydrogen bond coupling in the ketosteroid isomerase active site. (2009) (31)
- Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase (1997) (30)
- The high-resolution structures of the neutral and the low pH crystals of aminopeptidase from Aeromonas proteolytica (2006) (30)
- Structure determination of turkey egg-white lysozyme using Laue diffraction data. (1992) (30)
- Retromer in Alzheimer disease, Parkinson disease and other neurological disorders (2015) (30)
- The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). (2012) (30)
- Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine. (2004) (30)
- TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. (2000) (30)
- The Use of Pharmacological Retromer Chaperones in Alzheimer’s Disease and other Endosomal-related Disorders (2014) (29)
- Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor. (2009) (29)
- Strange days (2007) (29)
- D-CYCLOSERINE INACTIVATION OF D-AMINO ACID AMINOTRANSFERASE LEADS TO A STABLE NONCOVALENT PROTEIN COMPLEX WITH AN AROMATIC CYCLOSERINE-PLP DERIVATIVE (1998) (29)
- A novel structural basis for membrane association of a protein: construction of a chimeric soluble mutant of (S)-mandelate dehydrogenase from Pseudomonas putida. (1993) (29)
- A seat at the table (2008) (29)
- The structure of iron superoxide dismutase from Pseudomonas ovalis complexed with the inhibitor azide. (1990) (28)
- Going to the dogs (2008) (28)
- Metal-Dependent Function of a Mammalian Acireductone Dioxygenase. (2016) (28)
- Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time. (2018) (27)
- Endosomal recycling reconciles the Alzheimer’s disease paradox (2020) (27)
- Crystal structure at 1.8 A resolution of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis. (2004) (27)
- Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase. (2013) (27)
- Purification, catalytic properties and thermostability of 3-isopropylmalate dehydrogenase from Escherichia coli. (1997) (25)
- Mandelate racemase and class-related enzymes (1992) (25)
- Crystallization of yeast triose phosphate isomerase from polyethylene glycol. Protein crystal formation following phase separation. (1981) (24)
- The blue marble (2011) (24)
- Evolution of enzymatic activities in the enolase superfamily: Identification of a 'new' general acid catalyst in the active site of D- galactonate dehydratase from Escherichia coli (1999) (24)
- High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3 (2018) (23)
- Artifacts to avoid while taking advantage of top‐down mass spectrometry based detection of protein S‐thiolation (2014) (23)
- Estimation of uncertainties in X‐ray refinement results by use of perturbed structures (1987) (23)
- Crystal structure of the mutant yeast triosephosphate isomerase in which the catalytic base glutamic acid 165 is changed to aspartic acid. (1994) (23)
- Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors. (1995) (23)
- X-ray cryoenzymology. (1981) (22)
- When bigger is better (2010) (22)
- A structure of sperm whale myoglobin at a nitrogen gas pressure of 145 atmospheres. (1988) (22)
- [12] Flow cell construction and use (1985) (21)
- Model behavior (2001) (21)
- Proton Magnetic Resonance Spectrum of Polywater (1970) (21)
- Not just your average structures (1996) (21)
- Color blind (2004) (21)
- Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition. (2010) (21)
- Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase. (1994) (20)
- Probing the catalytic mechanism of yeast triose phosphate isomerase by site-specific mutagenesis. (1984) (20)
- Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase. (2009) (20)
- X-ray crystallographic studies of the alanine-specific racemase from Bacillus stearothermophilus. Overproduction, crystallization, and preliminary characterization. (1987) (20)
- PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation (2017) (20)
- Studies of calmodulin structure: laser raman spectroscopy of biomolecules. (1983) (19)
- Crystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution. (1990) (19)
- Déjá vu all over again (1991) (19)
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- Effects of X-irradiation of single crystals of ribonuclease A (1984) (0)
- Structure of porcine pancreatic elastase in 80% ethanol (2006) (0)
- Hell is a karaoke cruise (2001) (0)
- Functional Glutamate 151 to Histidine mutant of the aminopeptidase from Aeromonas Proteolytica. (2005) (0)
- The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT (2013) (0)
- Obituary: David Phillips (1924—99) (1999) (0)
- RAGWEED POLLEN ALLERGEN FROM AMBROSIA TRIFIDA V, NMR, 30 STRUCTURES (1998) (0)
- Ensemble model for Escherichia coli dihydrofolate reductase at 100K (2014) (0)
- Structure-Function Relationships in Mandelate Racemase and Muconate Lactonizing Enzyme (1990) (0)
- Advisory Board and Contents (2020) (0)
- A case of the flu (2012) (0)
- What if Watson had said "Apes evolved from man"? (2007) (0)
- HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH ADENOSINE (1997) (0)
- Foxes and hounds (2006) (0)
- Cysteinylation of the ALS‐Associated Protein SOD1 Confers Resistance to Oxidation (2015) (0)
- ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191F MUTATION, WITH BOUND MALEATE (2000) (0)
- HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT WITHOUT NUCLEOTIDE (1997) (0)
- Time-resolved crystallography : principles, problems and practice. Discussion (1992) (0)
- Crystal Structure of Ketosteroid Isomerase D40N from Pseudomonas putida (pKSI) with bound 2,6-difluorophenol (2007) (0)
- Crystal Structure of Co-type Nitrile Hydratase from Pseudomonas putida. (2011) (0)
- Crystal structure of the protein human CEACAM1 (2015) (0)
- Compositions et procédés permettant le diagnostic, le traitement et la prévention de la sclérose latérale amyotrophique et des maladies neurologiques apparentées (2008) (0)
- Crystal structure of V39A mutant of human CEACAM1 (0)
- How T-bet Binds to DNA (2010) (0)
- Juntendo Medical Journal (2015) (0)
- Dawn of structural biology (2003) (0)
- Structure of benzaldehyde lyase A28S mutant with monomethyl benzoylphosphonate (2010) (0)
- Benzaldehyde Dehydrogenase, a Class 3 Aldehyde Dehydrogenase, with bound NADP+ and Benzoate Adduct (2011) (0)
- Structure of porcine pancreatic elastase in 95% acetone (2006) (0)
- Mending walls (2012) (0)
- If you can't take any more of this, please press two (2002) (0)
- ASPARTATE AMINOTRANSFERASE FROM ESCHERICHIA COLI, C191W MUTATION, WITH BOUND MALEATE (2000) (0)
- Crystal Structure of Ketosteroid Isomerase D40N from Pseudomonas putida (pKSI) with bound phenol. (2006) (0)
- Second structure determinations. (1989) (0)
- Crystal structure of N97A mutant of human CEACAM1 (0)
- Hand-made biology (2010) (0)
- Anti-Cocaine Antibody 7.5.21, Crystal Form III (2005) (0)
- MOLECULAR MECHANICS CALCULATIONS ON CIS‐(PT(NH3)2(D(GPG))) ADDUCTS IN TWO OLIGONUCLEOTIDE DUPLEXES (1985) (0)
- Everything I need to know about genomics, I learned from Yogi Berra (2002) (0)
- Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the PLP-Aminoacrylate Intermediate (2018) (0)
- All proteins have to move to fold Native state ! ! Unfolded states ! (2017) (0)
- Structure of benzaldehyde lyase A28S mutant with benzoylphosphonate (2010) (0)
- Powerless to stop myself (2004) (0)
- Human DJ-1 with sulfinic acid (2004) (0)
- Out of Africa (2012) (0)
- X-ray crystal structure of bestatin bound to AAP (2004) (0)
- Structure of Mouse Acireductone dioxygenase with Ni2+ ion and D-lactic acid in the active site (2016) (0)
- For the good of the state (2003) (0)
- Trinity (2005) (0)
- 3-ISOPROPYLMALATE DEHYDROGENASE (IPMDH) FROM SALMONELLA TYPHIMURIUM (1999) (0)
- CHEMISTRY OF CAGED ENZYMES. BINDING OF PHOTOREVERSIBLE CINNAMATES TO CHYMOTRYPSIN (1990) (0)
- Our own petards (2002) (0)
- Half right (2005) (0)
- Senior moments (2006) (0)
- Crystal structure of I91A mutant of human CEACAM1 (0)
- Crystal Structure of the S18Y Variant of Ubiquitin Carboxy-terminal Hydrolase L1 (2014) (0)
- Dissecting Comorbidity between Parkinson's Disease and Melanoma in a Cell Culture Model (2017) (0)
- Crystal structure of the M180A mutant of the aminopeptidase from Vibrio proteolyticus in complex with leucine (2007) (0)
- Crystal structure of the human CEACAM1 membrane distal amino terminal (N)-domain (2014) (0)
- A Pathfinder in High-Pressure Bioscience: In Memoriam of Gaston Hui Bon Hoa (2021) (0)
- ANTI-COCAINE ANTIBODY M82G2 (2003) (0)
- Risky business (2011) (0)
- oxygen complex of p450cam from pseudomonas putida (2000) (0)
- The Next 100 Years of Crystallography: How the Heck should I Know? (2014) (0)
- Book Review:Principles of Protein X-Ray Crystallography Jan Drenth (2000) (0)
- E177K MUTANT OF D-AMINO ACID AMINOTRANSFERASE COMPLEXED WITH PYRIDOXAMINE-5'-PHOSPHATE (1998) (0)
- Crystal Structure of E. coli protein YajL (ThiJ) (2005) (0)
- Structure of Mouse Acirecutone dioxygenase with to Ni2+ and 2-keto-4-(methylthio)-butyric acid in the active site (2016) (0)
- MULTI-CONFORMER STRUCTURE OF RAGWEED POLLEN ALLERGEN FROM AMBROSIA TRIFIDA V, NMR, 2 STRUCTURES (1998) (0)
- 25-HYDROXYCHOLESTEROL AMPLIFIES MICROGLIAL NEUROINFLAMMATORY SIGNALING IN AN APOE ISOFORM-DEPENDENT MANNER (2018) (0)
- The dog particle (2012) (0)
- Out of Africa (2012) (0)
- Crystal Structure of Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) (2006) (0)
- Mending walls (2012) (0)
- Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: the Structure of the Catalytic Core (2018) (0)
- TransnitrosylationfromDJ-1toPTENAttenuatesNeuronal CellDeathinParkinson'sDiseaseModels (2014) (0)
- CRYSTAL STRUCTURE OF TERNARY COMPLEX OF TRITRICHOMONAS FOETUS INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE: STRUCTURAL CHARACTERIZATION OF NAD+ SITE IN MICROBIAL ENZYME (2003) (0)
- The Great Challenge: Neurodegenerative Disease (2015) (0)
- Max Perutz: Max in three dimensions (2007) (0)
- CHEMISTRY OF CAGED ENZYMES /II$. PHOTOACTIVATION OF INHIBITED CHYMOTRYPSIN (1990) (0)
- What is a chaperone in the context of pharmacology? (2009) (0)
- Anti-Cocaine Antibody M82G2 Complexed With meta-Oxybenzoylecgonine (2003) (0)
- Crystal Structure of the Tbox DNA binding domain of the transcription factor T-bet (2016) (0)
- Crystal Structure of Ketosteroid Isomerase D40N-D103N from Pseudomonas putida (pKSI) with bound equilenin (2009) (0)
- Atypical Kinase RIOK2 Is a Master Regulator of Hematopoietic Cell Fate (2021) (0)
- September 11, 01 (2001) (0)
- 1.6 Angstrom Resolution Structure of the Quorum-Quenching N-Acyl Homoserine Lactone Hydrolase of Bacillus thuringiensis (2005) (0)
- Not debatable (2008) (0)
- 1.3 Angstrom Structure of N-Acyl Homoserine Lactone Hydrolase with the Product N-Hexanoyl-L-Homocysteine Bound to The catalytic Metal Center (2008) (0)
- CITRATE BOUND, C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE (1998) (0)
- Nation of twits (2009) (0)
- STRUCTURE OF ENOYL-COA HYDRATASE COMPLEXED WITH THE SUBSTRATE DAC-COA (2002) (0)
- Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium (2021) (0)
- Structure of Apo Adenylate Kinase from Aquifex Aeolicus (2007) (0)
- Crystal Structure of Hip1 (Rv2224c) T466A mutant (2017) (0)
- HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP (1997) (0)
- Strcuture of Mouse Acireductone Dioxygenase bound to Co2+ and 2-keto-4-(methylthio)-butyric acid (2016) (0)
- Crystal Structure of YDR533Cp (2004) (0)
- Crystal Structure of B. thuringiensis AiiA mutant F107W with N-decanoyl-L-homoserine bound at the active site (2013) (0)
- Crystal structure of benzoylformate decarboxylase in complex with the pyridyl inhibitor 3-PKB (2008) (0)
- 3-ISOPROPYLMALATE DEHYDROGENASE (IPMDH) MUTANT (M219A)FROM THERMUS THERMOPHILUS (1999) (0)
- Seek and ye shall maybe find (2000) (0)
- Structure of a eukaryotic thiaminase-I bound to the thiamin analogue 3-deazathiamin (2013) (0)
- Still no flying cars (2003) (0)
- MANDELATE RACEMASE MUTANT D270N CO-CRYSTALLIZED WITH (S)-ATROLACTATE (1996) (0)
- Unreproducible results (1988) (0)
- Doctor Dunsel (2004) (0)
- Identity crisis (2004) (0)
- Crystal structure of the D118N mutant of the aminopeptidase from Vibrio proteolyticus (2007) (0)
- Structure of porcine pancreatic elastase in 40/50/10 cyclohexane (2006) (0)
- 3-ISOPROPYLMALATE DEHYDROGENASE FROM ESCHERICHIA COLI (1999) (0)
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