Grzegorz Grynkiewicz
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Polish biochemist
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Grzegorz Grynkiewiczbiology Degrees
Biology
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Molecular Biology
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Biochemistry
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Biology
Grzegorz Grynkiewicz's Degrees
- PhD Biochemistry University of Warsaw
- Masters Chemistry University of Warsaw
Why Is Grzegorz Grynkiewicz Influential?
(Suggest an Edit or Addition)Grzegorz Grynkiewicz's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A new generation of Ca2+ indicators with greatly improved fluorescence properties. (1985) (21365)
- Biologically useful chelators that release Ca2+ upon illumination (1988) (235)
- Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs. (2008) (189)
- Curcumin and curcuminoids in quest for medicinal status. (2012) (155)
- Interconversion of the salicylic acid signal and its glucoside in tobacco. (1993) (151)
- Genistein Improves Neuropathology and Corrects Behaviour in a Mouse Model of Neurodegenerative Metabolic Disease (2010) (130)
- Radical scavenging properties of genistein. (2003) (89)
- Synthetic derivatives of genistein, their properties and possible applications. (2010) (79)
- Synthesis of alkyl 4,6-di-o-acetyl-2,3-dideoxy-α-d-threo-hex-2- enopyranosides from 3,4,6-tri-o-acetyl-1,5-anhydro-2-deoxy- d-lyxo-hex-1-enitol (3,4,6-tri-o-acetyl-d-galactal) (1979) (70)
- Cytostatic and cytotoxic activity of synthetic genistein glycosides against human cancer cell lines. (2004) (68)
- Genistein inhibits glutamate-induced apoptotic processes in primary neuronal cell cultures: An involvement of aryl hydrocarbon receptor and estrogen receptor/glycogen synthase kinase-3β intracellular signaling pathway (2007) (63)
- Isoflavones, their Glycosides and Glycoconjugates. Synthesis and Biological Activity (2016) (61)
- New Perspectives for Fisetin (2019) (60)
- The Synthesis of Sugars from Non-Carbohydrate Substrates (1983) (57)
- Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers. (2011) (57)
- The encapsulation of idarubicin within liposomes using the novel EDTA ion gradient method ensures improved drug retention in vitro and in vivo. (2010) (49)
- Esterification of allylic alcohols with benzoic acid in the presence of diethyl azodicarboxylate and triphenylphosphine (1976) (47)
- Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids. (2005) (43)
- Synthetic conjugates of genistein affecting proliferation and mitosis of cancer cells. (2011) (43)
- Preclinical drug development. (2010) (39)
- Antiangiogenic and antitumour effects in vivo of genistein applied alone or combined with cyclophosphamide. (2001) (39)
- Interaction of quercetin, genistein and its derivatives with lipid bilayers – An ATR IR-spectroscopic study (2012) (38)
- Phytoestrogens in cancer prevention and therapy--mechanisms of their biological activity. (2005) (38)
- Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells (2012) (36)
- A facile and selective oxidation of sulfides to sulfones (1991) (34)
- Synthesis of 2,3-dideoxy-d-hex-2-enopyranosyl cyanides (1982) (33)
- Stereoselective synthesis of methyl β-dl-novioside (1976) (33)
- An Improved Synthesis and NMR Spectra of Benzylated Glycals (1989) (32)
- Differential effects of genistein, estradiol and raloxifene on rat osteoclasts in vitro. (2005) (29)
- Synthetic Genistein Glycosides Inhibiting EGFR Phosphorylation Enhance the Effect of Radiation in HCT 116 Colon Cancer Cells (2014) (28)
- THE SYNTHESIS OF GLYCOSYL FLUORIDES USING PYRIDINIUM POLY(HYDROGEN FLUORIDE) (1984) (26)
- A novel synthesis of aryl glycosides (1977) (25)
- Beneficial Effects of Vitamins K and D3 on Redox Balance of Human Osteoblasts Cultured with Hydroxyapatite-Based Biomaterials (2019) (25)
- Use of Unsaturated Sugars as Alkylating Agents. Addition of Enol Esters and Ethers to Glycals (1983) (25)
- In vitro antiviral activity of some uridine derivatives of 2-deoxy sugars against classical swine fever virus. (2010) (24)
- Unsaturated genistein disaccharide glycoside as a novel agent affecting microtubules. (2009) (24)
- Aromatic and heterocyclic 1-C-substituted derivatives of 1,5-anhydro-D-glucitol. (1984) (24)
- Pediatric microdose and microtracer studies using 14C in Europe (2015) (23)
- Suggestions for second-pass anti-COVID-19 drugs based on the Artificial Intelligence measures of molecular similarity, shape and pharmacophore distribution. (2020) (22)
- CHROMATOGRAPHIC QUANTIFICATION OF ISOFLAVONES (WHY AND HOW) (2005) (21)
- Observational infant exploratory [(14)C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis. (2015) (20)
- The synthesis of mixed carbonates from alcohols, dialkyl azodicarboxylate and tris(dimethylamino)-phosphine (1975) (19)
- Genistein derivatives decrease liposome membrane integrity--calcein release and molecular modeling study. (2008) (19)
- Synthetic genistein derivatives as modulators of glycosaminoglycan storage (2012) (17)
- Synthetic analogs of natural glycosides in drug discovery and development. (2008) (16)
- Electrophilic Substitution of Aromatic Compounds by Unsaturated Sugar Derivatives (1980) (15)
- Tropane alkaloids in pharmaceutical and phytochemical analysis. (2001) (14)
- A facile method for preparation of 3-thio-sugars and 3-thio-glycals. synthesis of 3′-mercapto-3′-deamino-doxorubicin (1991) (14)
- 2-Deoxy-1-O-silylated-β-hexopyranoses. Useful glycosyl donors and synthetic intermediates. (1991) (14)
- Synthesis of aldopyranosyl cyanides (1983) (14)
- Dose‐linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children (2019) (13)
- X-ray and 13C CP MAS investigations of structure of two genistein derivatives (2004) (12)
- Genistein alone or combined with cyclophosphamide may stimulate 16/C transplantable mouse mammary cancer growth. (2004) (12)
- Furan platform chemicals beyond fuels and plastics (2021) (11)
- The synthesis of N-glycosylphthalimides (1975) (11)
- Synthesis and antiviral activity of a novel glycosyl sulfoxide against classical swine fever virus. (2014) (11)
- Induction, modification, and perception of the salicylic acid signal in plant defence. (1994) (11)
- Novel Genistein Derivatives Induce Cell Death and Cell Cycle Arrest Through Different Mechanisms (2013) (11)
- Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex (2013) (11)
- Synthesis and Characterization of the Salicylic Acid β‐D‐ glucopyranoside. (1993) (10)
- Determination of new derivatives of genistein in culture media by liquid chromatography. (2004) (10)
- [Genistein: a soy isoflavone revealing a pleiotropic mechanism of action - clinical implications in the treatment and prevention of cancer]. (2004) (10)
- A Regioselective Synthesis of Genistein 4’-O-Ribofuranosides (2001) (10)
- SYNTHESIS AND CHARACTERIZATION OF THE SALICYLIC ACID BETA -D-GLUCOPYRANOSIDE (1993) (9)
- Synthetic Glycosides and Glycoconjugates of Low Molecular Weight Natural Products. (2016) (9)
- Synthesis and Cytotoxicity of 2,3-Enopyranosyl C-Linked Conjugates of Genistein (2014) (9)
- Synthesis and biological activity of O-acyl and O-alkyl chelidonine derivatives. (2001) (9)
- Interaction of genistein benzyl derivatives with lipid bilayers--fluorescence spectroscopic and calorimetric study. (2009) (9)
- Absorption and metabolism of biologically active genistein derivatives in colon carcinoma cell line (Caco-2). (2014) (8)
- Formation and Reactions of Glycal Derivatives (2001) (8)
- Novel pegylated liposomal formulation of docetaxel with 3-n-pentadecylphenol derivative for cancer therapy. (2021) (8)
- Protective Effects of Vitamin K Compounds on the Proteomic Profile of Osteoblasts under Oxidative Stress Conditions (2020) (8)
- Reductive rearrangement of 3,4,6-tri-O-acetyl-D-glucal (1984) (7)
- Reactions of glycals with furan and thiophene (1982) (7)
- Bioactive Isoflavone: Genistein — Synthesis and Prospective Applications (2001) (7)
- One step C-acylation of glycals and 2-deoxy-hexopyranoses at C-2 (1992) (7)
- Plant phenolics as drug leads -- what is missing? (2012) (7)
- Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle (2013) (6)
- C-Glycosidic Genistein Conjugates and Their Antiproliferative Activity (2013) (6)
- The synthesis of N-glycosyl-1,2-dialkoxycarbonylhydrazines (1975) (6)
- Synthesis of Selectively Protected Genistein Derivatives (2003) (5)
- Half a century with Achmatowicz rearrangement (2021) (5)
- Stereoselective Synthesis of 2,3-O-Isopropylidene-DL-Ribofuranose and Methyl β-DI-Ribopyranoside from furfuryl alcohol (1977) (5)
- Chemoselective deprotection of 1-O-acyl sugar derivatives (1989) (5)
- New Strategies Towards Synthesis of Doxorubicin Analogues. (2005) (5)
- Oseltamivir analog with boron cluster modulator. (2012) (5)
- Synthesis of some disaccharides containing pent-2-enopyranose residues (1980) (5)
- Synthesis of 1-O-silylated 3-azido- and 3-N-trifluoroacetamido-2,3,6- trideoxy-L-arabino and L-lyxo-hexopyranoses, convenient glycosyl donors for preparation of anthracycline antibiotics and related DNA-binding agents (2005) (5)
- Synthesis of 6-Alkoxy-2,3-dihydro-6H-pyran-3-ones from the 6-Acyloxy Derivatives (1979) (5)
- Liposomal formulation of idarubicin. (2003) (5)
- An approach to C-glycosidic conjugates of isoflavones (2013) (5)
- Triterpene sapogenins with oleanene skeleton: chemotypes and biological activities. (2014) (4)
- Solution conformation of the alkaloid chelidonine and its protonated form (2000) (4)
- The structure of benzyl 4‐O‐(2,3‐dideoxy‐α‐lpent‐2‐enopyranos‐4‐ulosyl)‐2,3‐O‐isopropylidene‐α‐l‐rhamnopyranoside (1982) (4)
- Isoflavone research towards healthcare applications (2020) (4)
- Synthesis of genistein 2,3-anhydroglycoconjugates -- potential antiproliferative agents. (2012) (4)
- The Synthesis of 6-Hydroxy-2H-pyran-3(6H)-onyl-hexoses, Potential Precursors of Disaccharides (1978) (3)
- CRYSTAL AND MOLECULAR STRUCTURE OF (-)-(S)-AND (+)-(R)-BROMOFOSFAMIDE (1999) (3)
- Comparison of ultraviolet detection and charged aerosol detection methods for liquid-chromatographic determination of protoescigenin. (2014) (3)
- THE EFFECT OF POLYPHENOLS ON MARKERS OF OXIDATIVE DAMAGE AND DMBA‐INDUCED CARCINOGENESIS IN RATS (2009) (3)
- Glycosylation of acid sensitive acceptors. Synthesis of (2,3-epoxy-1-propyl) glycosides. (2005) (3)
- Phytochemicals Between Nutrition and Medicine (2019) (3)
- Synthesis of the Sugar Moieties (2007) (3)
- Hexenoses in design of glycoconjugates - from chemistry to function (2014) (3)
- New synthesis of monosaccharide carbonates (1974) (2)
- Preparation of selectively protected protoescigenin derivatives for synthesis of escin analogs and neoglycoconjugates (2014) (2)
- Synthese neuer 1-C-(2-Furyl)- und 3-C-(2-Furyl)-hexapyranoside und 3-C-(2-Furyl)-daunorubicin-Analoge (Kurze Mitt.): Short communication (1991) (2)
- Commentary on the chromatographic retention of Chelidonium alkaloids (2001) (2)
- Technical Process for Preparation of Genistein (2016) (2)
- Oxidation - reduction esterrification by means of dimethyl mesoxalate and triphenylphosphine (1977) (2)
- Non-Cross-Resistant Anthracyclines with Reduced Basicity and Increased Stability of the Glycosidic Bond (1994) (1)
- Remarks of the USP recommendations for quantitative determination of idarubicin hydrochloride by HPLC (2000) (1)
- Inductive and field effects in aromatic substitution. Part III. Comparison of the substituents X and CH2X in nitration (1971) (1)
- Derivatives of Tunicamycin as Effective Inhibitors of Classical Swine Fever Virus (2009) (1)
- PERIODATE OXIDATION OF 14BETA -HYDROXYBUFA-4,20,22-TRIENOLID-3BETA -YL ALPHA -L-RHAMNOPYRANOSIDE (PROSCILLARIDIN). NEW RESULTS IN THE OLD REACTION (1996) (1)
- REACTIVITY OF 6-METHOXY-3,6-DIHYDRO-2H-PYRAN-3-ONE IN MICHAEL ADDITION (1978) (1)
- AN APPROACH TO STEREOSELECTIVE SYNTHESIS OF 6-SUBSTITUTED HEXOSES. SYNTHESIS OF RACEMIC METHYL 2,3,4-TRI-O-ACETYL-6-DEOXY-6-NITRO- AND 6-DEOXY-6-ACETAMIDO-α-MANNOPYRANOSIDES (1976) (1)
- From plant metabolites to emergence of privileged C-glycosyl scaffolds comprising useful synthetic glycoconjugates (2018) (1)
- Synthesis of Kedarosamine, a Sugar Portion of the Chromoprotein Antibiotic Kedarcidine. (1999) (1)
- Enantioselective high-performance liquid chromatography of chiral intermediates in the total synthesis of 4-demethoxydaunomycinone (1999) (1)
- Syntheses of Asymmetrically Substituted Pyrans of Natural Origin (2018) (1)
- Synthesis of protoescigenin glycoconjugates with O-28 triazole linker. (2014) (1)
- New Perspectives in Exploiting Secondary Metabolite Glycosides as Drug Leads (2015) (1)
- Microbial Reduction of 2‐Oxo‐4‐phenylbutyric Acid and Its Ester. (1997) (1)
- THE TOTAL SYNTHESIS OF CARBOHYDRATES 1972-1980 (1984) (1)
- THE O- VERSUS C-ALKYLATION DURING REACTIONS OF 6-BENZOYLOXY-2H-PYRAN-3(6H)-ONE WITH PHENOLS. MOLECULAR STRUCTURE OF A NEW BENZOFURAN DERIVATIVE (1980) (1)
- Związki naturalne w farmacji i medycynie. Kwas salicylowy i fenolokwasy.Natural products in pharmacy and medicine. Salicylic acid and related phenolic acids. (2010) (1)
- Phytoestrogens and Their Effects on Cancer (2005) (1)
- Synthetic genistein derivatives as modulators of glycosaminoglycan storage (2012) (1)
- AROMATIC AND HETEROCYCLIC 1‐C‐SUBSTITUTED DERIVATIVES OF 1,5‐ANHYDRO‐D‐GLUCITOL (1985) (1)
- New protoescigenin derivative for the treatment of Parkes Weber syndrome (2015) (1)
- ABSTRACT 707: 14C LABELLED PARACETAMOL MICROTRACER DOSING TO DETERMINE PHARMACOKINETICS FROM BIRTH TO 2 YEARS – INITIAL RESULTS OF THE PAMS STUDY (2014) (1)
- Synthesis of Selectively Protected Genistein Derivatives. (2004) (0)
- SYNTHESIS OF MIXED CARBONATES FROM ALCOHOLS, DIALKYL AZODICARBOXYLATE AND TRIS(DIMETHYLAMINO)PHOSPHINE (1975) (0)
- 521 POSTER Influence of new analogs and complexes of genistein on the expression of αvβ3 integrins on the A498 cell line (2006) (0)
- Horse chestnut saponins as a source of new materials for exploratory medicinal chemistry (2013) (0)
- Synthesis and Biological Activity of O‐Acyl and O‐Alkyl Chelidonine Derivatives. (2002) (0)
- MASS SPECTROMETRY OF 2,5-DIMETHOXY-2,5-DIHYDROFURAN DERIVATIVES PART 2 (1973) (0)
- Application of akcelerator mass spectroscopy (AMS) i early drug development. Part 2 Synthesis and certification of 14C-labelled compounds (2012) (0)
- ADDITION OF IODINE AZIDE TO METHYL 2,3-DIDEOXY-DL-PENT-2-ENOPYRANOS-4-ULOSIDE (1981) (0)
- Saponins of horse chestnuts. Traditional herbal medicine as a renewable chemical raw material Saponiny kasztanowca. Tradycyjny lek rolinny w roli odnawialnego surowca chemicznego (2015) (0)
- Plant Isoflavones, their Impact on Life Sciences, Medicine and Industry (2017) (0)
- ABSTRACT 131: PAMS (2014) (0)
- 16α,17α-ACETAL GLUCOCORTICOSTEROIDAL DERIVATIVES (1994) (0)
- Tropane alkaloids in pharmaceutical and phytochemical analysis. (2002) (0)
- A short history of MKNOL (2015) (0)
- Achmatowicz Rearrangement Derived Synthons, and their Relevant Bioinspired Chemistry (2018) (0)
- NEW SYNTHESIS OF O- AND S-GLYCOSYL DERIVATIVES OF 2-CHLORO-3-CYANO-5-NITROPYRIDINE (2001) (0)
- A Facile Method for Preparation of 3-Thio Sugars and 3-Thio Glycals. Synthesis of 3′-Mercapto-3′-deaminodoxorubicin. (1992) (0)
- P27 GENISTEIN INHIBITS GLUTAMATE-INDUCED APOPTOSIS IN PRIMARY NEURONAL CELL CULTURES OF MOUSE BRAIN CORTEX AND CEREBELLUM (2006) (0)
- Preliminary evaluation of CNS effects of 6-O-substituted chelidonine derivatives. (2003) (0)
- One‐Step C‐Acylation of Glycals and 2‐Deoxyhexopyranoses at C‐2. (1993) (0)
- SYNTHESIS OF PHENYL GLYCOSIDES BY DIRECT REPLACEMENT OF ANOMERIC HYDROXYL GROUP (1980) (0)
- Inductive and field effects in aromatic substitution. Part II. Nitration of benzotrichloride and βββ-trichloroethylbenzene (1971) (0)
- Direct Transformation of Methyl Glycopyranosides into Corresponding Glycosyl Halides. (1988) (0)
- Old drugs in new therapeutic indications - the case of chloroquine (2020) (0)
- REACTION OF 1,2-3,4-DI-O-ISOPROPYLIDENE-α-D-GALACTOPYRANOSE WITH DIALKYL AZODICARBOXYLATE IN THE PRESENCE OF TRIPHENYLPHOSPHINE (1976) (0)
- Vegetable sources of chemical and pharmaceutical intermediates . Example of triterpene isolated from horse (0)
- [Methods of obtaining pure enantiomeric compounds]. (1993) (0)
- A Facile and Selective Oxidation of Sulfides to Sulfones. (1992) (0)
- Biologically Useful Chelators That Release Ca2+ Upon Illumination. (1988) (0)
- Natural versus synthetic genistein in a drug development perspective (2001) (0)
- Antiviral Activity of a Thioglycoside Derivative Mimicking Tunicamycin Structure (2011) (0)
- SYNTHESIS OF 2,3‐DIDEOXY‐D‐HEX‐2‐ENOPYRANOSYL CYANIDES (1983) (0)
- CONFORMATION OF 4-(2-FURYL)-6-METHYL-5-NITRO-2-PHENYL- AND 4-(2-FURYL)-2,2,6-TRIMETHYL-5-NITRO-1,3-DIOXANES (1976) (0)
- Conversion of 2-Furfuryl Alcohols (I) into 2H-Pyran-3(6H)-ones (II). (1988) (0)
- Chemically Synthesized Tunicamycin Derivatives Effectively Inhibit the Propagation of Classical Swine Fever Virus—A Surrogate Model for Hepatitis C Virus (2008) (0)
- Synthesis of New 1‐C‐(2‐Furyl)‐ and 3‐C‐(2‐Furyl)‐hexopyranosides and 3‐C‐(2‐Furyl)‐daunorubicin Analogs. (1991) (0)
- PO-0934 Comparative Paediatric Acetaminophen Pharmacokinetics Between A Microdose And A Therapeutic Dose Using Accelerator Mass Spectrometry Bioanalysis (2014) (0)
- 2-Deoxy-1-O-Silylated β-Hexopyranoses. Useful Glycosyl Donors and Synthetic Intermediates. (1992) (0)
- OXIDATION-REDUCTION ESTERIFICATION BY MEANS OF DIMETHYL MESOXALATE AND TRIPHENYLPHOSPHINE (1977) (0)
- CIS-TRANS-ISOMERE 2-SUBSTITUIERTER 2,5-DIMETHOXY-2,5-DIHYDRO-FURANE (1972) (0)
- An Improved Synthesis and NMR Spectra of Benzylated Glycals. (1990) (0)
- The Total Synthesis of Carbohydrates 1972–1980 (2007) (0)
- Open Access dynamics and prospects (2015) (0)
- THE SYNTHESIS OF 6‐HYDROXY‐2H‐PYRAN‐3(6H)‐ONYLHEXOSES, POTENTIAL PRECURSORS OF DISACCHARIDES (1979) (0)
- A Facile Transformation of Benzylated Methyl Glycosides to Thioglycosides. (1996) (0)
- ACYLATION IN PRESENCE OF DIETHYL AZODICARBOXYLATE AND TRIPHENYLPHOSPHINE (1976) (0)
- Novel Synthesis of Anomeric Peroxides and Hydroperoxides. (2000) (0)
- Quantitative determination of chelidonine in Cynarein tablets by HPLC (2000) (0)
- Medical potential of genistein - a bioactive isoflavone. (2000) (0)
- Periodate Oxidation of 14β‐Hydroxybufa‐4,20,22‐trienolid‐3β‐ yl α‐L‐Rhamnopyranoside (Proscillaridin). New Results in the Old Reaction. (2010) (0)
- SELECTIVE TRANSFORMATIONS OF SOME ALKYL HEXOPYRANOSIDES IN THE PRESENCE OF DIETHYL AZODICARBOXYLATE AND TRIPHENYLPHOSPHINE (1980) (0)
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Grzegorz Grynkiewicz is affiliated with the following schools:
